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Bull."],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's disease (AD) is the most prevalent neurodegenerative disease featuring progressive cognitive impairment. Although the etiology of late-onset AD remains unclear, the close association of AD with apolipoprotein E (APOE), a gene that mainly regulates lipid metabolism, has been firmly established and may shed light on the exploration of AD pathogenesis and therapy. However, various confounding factors interfere with the <jats:italic>APOE<\/jats:italic>-related AD risk, raising questions about our comprehension of the clinical findings concerning <jats:italic>APOE<\/jats:italic>. In this review, we summarize the most debated factors interacting with the <jats:italic>APOE<\/jats:italic> genotype and AD pathogenesis, depict the extent to which these factors relate to <jats:italic>APOE<\/jats:italic>-dependent AD risk, and discuss the possible underlying mechanisms.<\/jats:p>","DOI":"10.1007\/s12264-021-00814-5","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T19:02:20Z","timestamp":1644606140000},"page":"809-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Factors Influencing Alzheimer\u2019s Disease Risk: Whether and How They are Related to the APOE Genotype"],"prefix":"10.1007","volume":"38","author":[{"given":"Rong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-2705","authenticated-orcid":false,"given":"Weidong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"814_CR1","doi-asserted-by":"publisher","DOI":"10.20517\/and.2021.01","author":"WD Le","year":"2021","unstructured":"Le WD. 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