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Bull."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice, and the lateral intraparietal cortex (LIP) is implicated in this process. In this study, we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently. We discovered that the animal\u2019s choice was dictated by the reward amount while the luminance had a marginal effect. In the LIP, neuronal activity corresponded well with the animal\u2019s choice pattern, in that a majority of reward-modulated neurons encoded the reward amount in the neuron\u2019s preferred hemifield with a positive slope. In contrast, compared to their responses to low luminance, an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity, leading to a much weaker population-level response. Meanwhile, in the non-preferred hemifield, the strength of encoding for reward amount and luminance was positively correlated, suggesting the integration of these two factors in the LIP. Moreover, neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP. Overall, our study provides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions.<\/jats:p>","DOI":"10.1007\/s12264-022-00948-0","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T13:02:35Z","timestamp":1663419755000},"page":"14-28","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuronal Response to Reward and Luminance in Macaque LIP During Saccadic Choice"],"prefix":"10.1007","volume":"39","author":[{"given":"Ziqi","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"948_CR1","doi-asserted-by":"publisher","first-page":"9298","DOI":"10.1523\/JNEUROSCI.0908-11.2011","volume":"31","author":"DA Markowitz","year":"2011","unstructured":"Markowitz DA, Shewcraft RA, Wong YT, Pesaran B. 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