{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:20:58Z","timestamp":1789478458258,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s12264-022-00951-5","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T09:02:32Z","timestamp":1664010152000},"page":"881-892","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer\u2019s Mouse Model of Amyloid Deposition"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-8578","authenticated-orcid":false,"given":"Chang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokuang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baomei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Shakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deveroux","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenfeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"951_CR1","first-page":"329","volume":"65","author":"VJ De-Paula","year":"2012","unstructured":"De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV. Alzheimer\u2019s disease. Subcell Biochem 2012, 65: 329\u2013352.","journal-title":"Sub Cell Biochem"},{"key":"951_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41582-022-00642-9","volume":"18","author":"T G\u00f3mez-Isla","year":"2022","unstructured":"G\u00f3mez-Isla T, Frosch MP. Lesions without symptoms: Understanding resilience to Alzheimer disease neuropathological changes. Nat Rev Neurol 2022, 18: 323\u2013332.","journal-title":"Nat Rev Neurol"},{"key":"951_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","volume":"167","author":"JA Soria Lopez","year":"2019","unstructured":"Soria Lopez JA, Gonz\u00e1lez HM, L\u00e9ger GC. Alzheimer\u2019s disease. Handb Clin Neurol 2019, 167: 231\u2013255.","journal-title":"Handb Clin Neurol"},{"key":"951_CR4","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s12264-021-00716-6","volume":"37","author":"Y Ying","year":"2021","unstructured":"Ying Y, Wang JZ. Illuminating neural circuits in Alzheimer\u2019s disease. Neurosci Bull 2021, 37: 1203\u20131217.","journal-title":"Neurosci Bull"},{"key":"951_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-007-0312-8","volume":"115","author":"C Duyckaerts","year":"2008","unstructured":"Duyckaerts C, Potier MC, Delatour B. Alzheimer disease models and human neuropathology: Similarities and differences. Acta Neuropathol 2008, 115: 5\u201338.","journal-title":"Acta Neuropathol"},{"key":"951_CR6","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s12264-021-00670-3","volume":"37","author":"X Long","year":"2021","unstructured":"Long X, Tao Y, Chen XC, Deng B, Cai J, Zhang SJ. Getting lost: Place cells and grid cells in rodent models of Alzheimer\u2019s disease. Neurosci Bull 2021, 37: 894\u2013897.","journal-title":"Neurosci Bull"},{"key":"951_CR7","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation. J Neurosci 2006, 26: 10129\u201310140.","journal-title":"J Neurosci"},{"key":"951_CR8","doi-asserted-by":"publisher","first-page":"5272014","DOI":"10.1155\/2018\/5272014","volume":"2018","author":"SJ Oh","year":"2018","unstructured":"Oh SJ, Lee HJ, Kang KJ, Han SJ, Lee YJ, Lee KC, et al. Early detection of A \u03b2 deposition in the 5xFAD mouse by amyloid PET. Contrast Media Mol Imaging 2018, 2018: 5272014.","journal-title":"Contrast Media Mol Imaging"},{"key":"951_CR9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3233\/JAD-143120","volume":"45","author":"BC Richard","year":"2015","unstructured":"Richard BC, Kurdakova A, Baches S, Bayer TA, Weggen S, Wirths O. Gene dosage dependent aggravation of the neurological phenotype in the 5XFAD mouse model of Alzheimer\u2019s disease. J Alzheimers Dis 2015, 45: 1223\u20131236.","journal-title":"J Alzheimers Dis"},{"key":"951_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","volume":"33","author":"R Kimura","year":"2009","unstructured":"Kimura R, Ohno M. Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiol Dis 2009, 33: 229\u2013235.","journal-title":"Neurobiol Dis"},{"key":"951_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuroscience.2013.09.016","volume":"254","author":"Y Buskila","year":"2013","unstructured":"Buskila Y, Crowe SE, Ellis-Davies GCR. Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice. Neuroscience 2013, 254: 152\u2013159.","journal-title":"Neuroscience"},{"key":"951_CR12","doi-asserted-by":"crossref","unstructured":"Tible M, Mouton Liger F, Schmitt J, Giralt A, Farid K, Thomasseau S, et al. PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions. PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions. Aging Cell 2019, 18: e12887","DOI":"10.1111\/acel.12887"},{"key":"951_CR13","doi-asserted-by":"crossref","unstructured":"Angel A, Volkman R, Royal TG, Offen D. Caspase-6 knockout in the 5xFAD model of Alzheimer's disease reveals favorable outcome on memory and neurological hallmarks. Int J Mol Sci 2020, 21: 1144.","DOI":"10.3390\/ijms21031144"},{"key":"951_CR14","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","volume":"177","author":"AJ Martorell","year":"2019","unstructured":"Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, et al. Multi-sensory gamma stimulation ameliorates Alzheimer\u2019s-associated pathology and improves cognition. Cell 2019, 177: 256-271.e22.","journal-title":"Cell"},{"key":"951_CR15","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.cell.2014.01.065","volume":"157","author":"J Seo","year":"2014","unstructured":"Seo J, Giusti-Rodr\u00edguez P, Zhou Y, Rudenko A, Cho S, Ota KT, et al. Activity-dependent p25 generation regulates synaptic plasticity and a\u03b2-induced cognitive impairment. Cell 2014, 157: 486\u2013498.","journal-title":"Cell"},{"key":"951_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","volume":"28","author":"G Feng","year":"2000","unstructured":"Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000, 28: 41\u201351.","journal-title":"Neuron"},{"key":"951_CR17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/biof.41","volume":"35","author":"JE Bradley","year":"2009","unstructured":"Bradley JE, Ramirez G, Hagood JS. Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype. Biofactors 2009, 35: 258\u2013265.","journal-title":"Biofactors"},{"key":"951_CR18","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.1523\/JNEUROSCI.6569-10.2011","volume":"31","author":"S Qiu","year":"2011","unstructured":"Qiu S, Anderson CT, Levitt P, Shepherd GMG. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci 2011, 31: 5855\u20135864.","journal-title":"J Neurosci"},{"key":"951_CR19","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.neuron.2008.01.028","volume":"57","author":"A Terashima","year":"2008","unstructured":"Terashima A, Pelkey KA, Rah JC, Suh YH, Roche KW, Collingridge GL, et al. An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity. Neuron 2008, 57: 872\u2013882.","journal-title":"Neuron"},{"key":"951_CR20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/375400a0","volume":"375","author":"D Liao","year":"1995","unstructured":"Liao D, Hessler NA, Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 1995, 375: 400\u2013404.","journal-title":"Nature"},{"key":"951_CR21","doi-asserted-by":"publisher","first-page":"16166","DOI":"10.1523\/JNEUROSCI.2580-14.2014","volume":"34","author":"S Qiu","year":"2014","unstructured":"Qiu S, Lu Z, Levitt P. MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus. J Neurosci 2014, 34: 16166\u201316179.","journal-title":"J Neurosci"},{"key":"951_CR22","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1152\/jn.00869.2006","volume":"97","author":"S Qiu","year":"2007","unstructured":"Qiu S, Weeber EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 2007, 97: 2312\u20132321.","journal-title":"J Neurophysiol"},{"key":"951_CR23","doi-asserted-by":"publisher","first-page":"12943","DOI":"10.1523\/JNEUROSCI.2561-06.2006","volume":"26","author":"S Qiu","year":"2006","unstructured":"Qiu S, Zhao LF, Korwek KM, Weeber EJ. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. J Neurosci 2006, 26: 12943\u201312955.","journal-title":"J Neurosci"},{"key":"951_CR24","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/mp.2015.182","volume":"21","author":"Y Peng","year":"2016","unstructured":"Peng Y, Lu Z, Li G, Piechowicz M, Anderson M, Uddin Y, et al. The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain. Mol Psychiatry 2016, 21: 925\u2013935.","journal-title":"Mol Psychiatry"},{"key":"951_CR25","first-page":"387","volume":"87","author":"DA Sholl","year":"1953","unstructured":"Sholl DA. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 1953, 87: 387\u2013406.","journal-title":"J Anat"},{"key":"951_CR26","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1093\/bioinformatics\/btr390","volume":"27","author":"MH Longair","year":"2011","unstructured":"Longair MH, Baker DA, Armstrong JD. Simple Neurite Tracer: Open source software for reconstruction, visualization and analysis of neuronal processes. Bioinformatics 2011, 27: 2453\u20132454.","journal-title":"Bioinformatics"},{"key":"951_CR27","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/nn1302","volume":"7","author":"MC Herzig","year":"2004","unstructured":"Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, et al. A\u03b2 is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci 2004, 7: 954\u2013960.","journal-title":"Nat Neurosci"},{"key":"951_CR28","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/nn736","volume":"4","author":"M Matsuzaki","year":"2001","unstructured":"Matsuzaki M, Ellis-Davies GCR, Nemoto T, Miyashita Y, Iino M, Kasai H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci 2001, 4: 1086\u20131092.","journal-title":"Nat Neurosci"},{"key":"951_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.nlm.2005.11.001","volume":"85","author":"S Qiu","year":"2006","unstructured":"Qiu S, Korwek KM, Pratt-Davis AR, Peters M, Bergman MY, Weeber EJ. Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice. Neurobiol Learn Mem 2006, 85: 228\u2013242.","journal-title":"Neurobiol Learn Mem"},{"key":"951_CR30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neuron.2009.06.007","volume":"63","author":"YH Huang","year":"2009","unstructured":"Huang YH, Lin Y, Mu P, Lee BR, Brown TE, Wayman G, et al. In vivo cocaine experience generates silent synapses. Neuron 2009, 63: 40\u201347.","journal-title":"Neuron"},{"key":"951_CR31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0896-6273(95)90046-2","volume":"15","author":"JTR Isaac","year":"1995","unstructured":"Isaac JTR, Nicoll RA, Malenka RC. Evidence for silent synapses: Implications for the expression of LTP. Neuron 1995, 15: 427\u2013434.","journal-title":"Neuron"},{"key":"951_CR32","doi-asserted-by":"crossref","unstructured":"Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998, 4: 97\u2013100.","DOI":"10.1038\/nm0198-097"},{"key":"951_CR33","doi-asserted-by":"publisher","first-page":"8004","DOI":"10.1523\/JNEUROSCI.5369-11.2012","volume":"32","author":"CM William","year":"2012","unstructured":"William CM, Andermann ML, Goldey GJ, Roumis DK, Reid RC, Shatz CJ, et al. Synaptic plasticity defect following visual deprivation in Alzheimer\u2019s disease model transgenic mice. J Neurosci 2012, 32: 8004\u20138011.","journal-title":"J Neurosci"},{"key":"951_CR34","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41597-021-01054-y","volume":"8","author":"S Forner","year":"2021","unstructured":"Forner S, Kawauchi S, Balderrama-Gutierrez G, Kram\u00e1r EA, Matheos DP, Phan J, et al. Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease. Sci Data 2021, 8: 270.","journal-title":"Sci Data"},{"key":"951_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.713726","volume":"13","author":"AL Oblak","year":"2021","unstructured":"Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, et al. Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: A MODEL-AD study. Front Aging Neurosci 2021, 13: 713726.","journal-title":"Front Aging Neurosci"},{"key":"951_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1767147","author":"EA Huwait","year":"2020","unstructured":"Huwait EA, Baghallab IM, Glabe CG, Abulnaja KO, Kumosani TA, Moselhy SS. Identification of amyloid antibodies for Alzheimer disease-immunotherapy. Arch Physiol Biochem 2020, https:\/\/doi.org\/10.1080\/13813455.2020.1767147.","journal-title":"Arch Physiol Biochem"},{"key":"951_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12896-015-0146-8","volume":"15","author":"P Droste","year":"2015","unstructured":"Droste P, Frenzel A, Steinwand M, Pelat T, Thullier P, Hust M, et al. Structural differences of amyloid-\u03b2 fibrils revealed by antibodies from phage display. BMC Biotechnol 2015, 15: 57.","journal-title":"BMC Biotechnol"},{"key":"951_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105344","volume":"154","author":"CM William","year":"2021","unstructured":"William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, et al. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiol Dis 2021, 154: 105344.","journal-title":"Neurobiol Dis"},{"key":"951_CR39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13024-021-00457-0","volume":"16","author":"DP Benitez","year":"2021","unstructured":"Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, et al. Knock-in models related to Alzheimer\u2019s disease: Synaptic transmission, plaques and the role of microglia. Mol Neurodegener 2021, 16: 47.","journal-title":"Mol Neurodegener"},{"key":"951_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nrn.2017.29","volume":"18","author":"UC M\u00fcller","year":"2017","unstructured":"M\u00fcller UC, Deller T, Korte M. Not just amyloid: Physiological functions of the amyloid precursor protein family. Nat Rev Neurosci 2017, 18: 281\u2013298.","journal-title":"Nat Rev Neurosci"},{"key":"951_CR41","doi-asserted-by":"publisher","first-page":"jcs242917","DOI":"10.1242\/jcs.242917","volume":"133","author":"S Probst","year":"2020","unstructured":"Probst S, Kr\u00fcger M, K\u00e4gi L, Th\u00f6ni S, Schuppli D, Nitsch RM, et al. Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein. J Cell Sci 2020, 133: jcs242917.","journal-title":"J Cell Sci"},{"key":"951_CR42","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020107471","volume":"40","author":"V Steubler","year":"2021","unstructured":"Steubler V, Erdinger S, Back MK, Ludewig S, F\u00e4ssler D, Richter M, et al. Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype. EMBO J 2021, 40: e107471.","journal-title":"EMBO J"},{"key":"951_CR43","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1152\/physiolgenomics.00006.2019","volume":"51","author":"P Xu","year":"2019","unstructured":"Xu P, Chen A, Li Y, Xing X, Lu H. Medial prefrontal cortex in neurological diseases. Physiol Genomics 2019, 51: 432\u2013442.","journal-title":"Physiol Genomics"},{"key":"951_CR44","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jnc.14136","volume":"144","author":"P Bazzigaluppi","year":"2018","unstructured":"Bazzigaluppi P, Beckett TL, Koletar MM, Lai AY, Joo IL, Brown ME, et al. Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer\u2019s disease. J Neurochem 2018, 144: 669\u2013679.","journal-title":"J Neurochem"},{"key":"951_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3233\/JAD-190564","volume":"72","author":"I Har-Paz","year":"2019","unstructured":"Har-Paz I, Roisman N, Michaelson DM, Moran A. Extra-hippocampal learning deficits in young apolipoprotein E4 mice and their synaptic underpinning. J Alzheimers Dis 2019, 72: 71\u201382.","journal-title":"J Alzheimers Dis"},{"key":"951_CR46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.pneurobio.2016.06.004","volume":"143","author":"KP Kepp","year":"2016","unstructured":"Kepp KP. Alzheimer\u2019s disease due to loss of function: A new synthesis of the available data. Prog Neurobiol 2016, 143: 36\u201360.","journal-title":"Prog Neurobiol"},{"key":"951_CR47","first-page":"7132","volume":"24","author":"M Maulik","year":"2015","unstructured":"Maulik M, Peake K, Chung J, Wang Y, Vance JE, Kar S. APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer\u2019s disease. Hum Mol Genet 2015, 24: 7132\u20137150.","journal-title":"Hum Mol Genet"},{"key":"951_CR48","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.nbd.2012.03.030","volume":"47","author":"A Bhalla","year":"2012","unstructured":"Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, di Paolo G, Small SA. The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis 2012, 47: 126\u2013134.","journal-title":"Neurobiol Dis"},{"key":"951_CR49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1385\/NMM:6:1:053","volume":"6","author":"CW Xie","year":"2004","unstructured":"Xie CW. Calcium-regulated signaling pathways: Role in amyloid beta-induced synaptic dysfunction. Neuromolecular Med 2004, 6: 53\u201364.","journal-title":"Neuromolecular Med"},{"key":"951_CR50","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/978-94-007-2888-2_54","volume":"740","author":"NK Woods","year":"2012","unstructured":"Woods NK, Padmanabhan J. Neuronal calcium signaling and Alzheimer\u2019s disease. Adv Exp Med Biol 2012, 740: 1193\u20131217.","journal-title":"Adv Exp Med Biol"},{"key":"951_CR51","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/j.neurobiolaging.2014.02.006","volume":"35","author":"C Ari","year":"2014","unstructured":"Ari C, Borysov SI, Wu J, Padmanabhan J, Potter H. Alzheimer amyloid beta inhibition of Eg5\/kinesin 5 reduces neurotrophin and\/or transmitter receptor function. Neurobiol Aging 2014, 35: 1839\u20131849.","journal-title":"Neurobiol Aging"},{"key":"951_CR52","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12264-019-00429-x","volume":"36","author":"DY Fan","year":"2020","unstructured":"Fan DY, Wang YJ. Early intervention in Alzheimer\u2019s disease: How early is early enough? Neurosci Bull 2020, 36: 195\u2013197.","journal-title":"Neurosci Bull"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-022-00951-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-022-00951-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-022-00951-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T03:39:23Z","timestamp":1686713963000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-022-00951-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,24]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["951"],"URL":"https:\/\/doi.org\/10.1007\/s12264-022-00951-5","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,24]]},"assertion":[{"value":"26 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}