{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:54:22Z","timestamp":1793386462984,"version":"4.5.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Coronavirus Disease 2019 (COVID-19) pandemic has had an adverse impact on the physical and mental health of the public worldwide. In addition to illness in patients with COVID-19, isolated people and the general population have experienced mental health problems due to social distancing policies, mandatory lockdown, and other psychosocial factors, and the prevalence of depression and anxiety significantly increased during the pandemic. The purpose of this review is to elucidate the epidemiology, contributing factors, and pathogenesis of depression and anxiety. during the pandemic. These findings indicate that physicians and psychiatrists should pay more attention to and identify those with a high risk for mental problems, such as females, younger people, unmarried people, and those with a low educational level. In addition, researchers should focus on identifying the neural and neuroimmune mechanisms involved in depression and anxiety, and assess the intestinal microbiome to identify effective biomarkers. We also provide an overview of various intervention methods, including pharmacological treatment, psychological therapy, and physiotherapy, to provide a reference for different populations to guide the development of optimized intervention methods.<\/jats:p>","DOI":"10.1007\/s12264-022-00970-2","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T04:32:04Z","timestamp":1669091524000},"page":"675-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Depression and Anxiety During the COVID-19 Pandemic: Epidemiology, Mechanism, and Treatment"],"prefix":"10.1007","volume":"39","author":[{"given":"Chunyan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"970_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jare.2020.03.005","volume":"24","author":"MA Shereen","year":"2020","unstructured":"Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res 2020, 24: 91\u201398.","journal-title":"J Adv Res"},{"key":"970_CR2","unstructured":"Collaborators C1MD. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet 2021, 398: 1700\u20131712."},{"key":"970_CR3","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1002\/jmv.27588","volume":"94","author":"Y Araf","year":"2022","unstructured":"Araf Y, Akter F, Tang YD, Fatemi R, Parvez MSA, Zheng C. Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines. J Med Virol 2022, 94: 1825\u20131832.","journal-title":"J Med Virol"},{"key":"970_CR4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/nyas.14506","volume":"1486","author":"J Deng","year":"2021","unstructured":"Deng J, Zhou F, Hou W, Silver Z, Wong CY, Chang O, et al. The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: A meta-analysis. Ann N Y Acad Sci 2021, 1486: 90\u2013111.","journal-title":"Ann N Y Acad Sci"},{"key":"970_CR5","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00787-020-01541-4","volume":"29","author":"SJ Zhou","year":"2020","unstructured":"Zhou SJ, Zhang LG, Wang LL, Guo ZC, Wang JQ, Chen JC, et al. Prevalence and socio-demographic correlates of psychological health problems in Chinese adolescents during the outbreak of COVID-19. Eur Child Adolesc Psychiatry 2020, 29: 749\u2013758.","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"970_CR6","doi-asserted-by":"publisher","first-page":"102092","DOI":"10.1016\/j.ajp.2020.102092","volume":"51","author":"MZ Ahmed","year":"2020","unstructured":"Ahmed MZ, Ahmed O, Zhou A, Sang H, Liu S, Ahmad A. Epidemic of COVID-19 in China and associated psychological problems. Asian J Psychiatry 2020, 51: 102092.","journal-title":"Asian J Psychiatry"},{"key":"970_CR7","doi-asserted-by":"publisher","first-page":"e0231924","DOI":"10.1371\/journal.pone.0231924","volume":"15","author":"J Gao","year":"2020","unstructured":"Gao J, Zheng P, Jia Y, Chen H, Mao Y, Chen S, et al. Mental health problems and social media exposure during COVID-19 outbreak. PLoS One 2020, 15: e0231924.","journal-title":"PLoS One"},{"key":"970_CR8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10964-020-01332-9","volume":"50","author":"NR Magson","year":"2021","unstructured":"Magson NR, Freeman JYA, Rapee RM, Richardson CE, Oar EL, Fardouly J. Risk and protective factors for prospective changes in adolescent mental health during the COVID-19 pandemic. J Youth Adolescence 2021, 50: 44\u201357.","journal-title":"J Youth Adolescence"},{"key":"970_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/13548506.2020.1746817","volume":"26","author":"Y Wang","year":"2021","unstructured":"Wang Y, Di Y, Ye J, Wei W. Study on the public psychological states and its related factors during the outbreak of coronavirus disease 2019 (COVID-19) in some regions of China. Psychol Health Med 2021, 26: 13\u201322.","journal-title":"Psychol Health Med"},{"key":"970_CR10","doi-asserted-by":"publisher","first-page":"112992","DOI":"10.1016\/j.psychres.2020.112992","volume":"288","author":"F Tian","year":"2020","unstructured":"Tian F, Li H, Tian S, Yang J, Shao J, Tian C. Psychological symptoms of ordinary Chinese citizens based on SCL-90 during the level I emergency response to COVID-19. Psychiatry Res 2020, 288: 112992.","journal-title":"Psychiatry Res"},{"key":"970_CR11","doi-asserted-by":"crossref","unstructured":"Creese B, Khan Z, Henley W, O'Dwyer S, Corbett A, Vasconcelos Da Silva M, et al. Loneliness, physical activity, and mental health during COVID-19: A longitudinal analysis of depression and anxiety in adults over the age of 50 between 2015 and 2020. Int Psychogeriatr 2021, 33: 505\u2013514.","DOI":"10.1017\/S1041610220004135"},{"key":"970_CR12","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1017\/S1041610220001258","volume":"32","author":"YS Bergman","year":"2020","unstructured":"Bergman YS, Cohen-Fridel S, Shrira A, Bodner E, Palgi Y. COVID-19 health worries and anxiety symptoms among older adults: The moderating role of ageism. Int Psychogeriatr 2020, 32: 1371\u20131375.","journal-title":"Int Psychogeriatr"},{"key":"970_CR13","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.3390\/ijerph17093165","volume":"17","author":"C Mazza","year":"2020","unstructured":"Mazza C, Ricci E, Biondi S, Colasanti M, Ferracuti S, Napoli C, et al. A nationwide survey of psychological distress among Italian people during the COVID-19 pandemic: Immediate psychological responses and associated factors. Int J Environ Res Public Health 2020, 17: 3165.","journal-title":"Int J Environ Res Public Health"},{"key":"970_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12888-021-03655-8","volume":"22","author":"MT Pedersen","year":"2022","unstructured":"Pedersen MT, Andersen TO, Clotworthy A, Jensen AK, Strandberg-Larsen K, Rod NH, et al. Time trends in mental health indicators during the initial 16 months of the COVID-19 pandemic in Denmark. BMC Psychiatry 2022, 22: 25.","journal-title":"BMC Psychiatry"},{"key":"970_CR15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1017\/neu.2020.15","volume":"32","author":"KM S\u00f8nderskov","year":"2020","unstructured":"S\u00f8nderskov KM, Dinesen PT, Santini ZI, \u00d8stergaard SD. The depressive state of Denmark during the COVID-19 pandemic. Acta Neuropsychiatr 2020, 32: 226\u2013228.","journal-title":"Acta Neuropsychiatr"},{"key":"970_CR16","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1080\/09603123.2020.1802409","volume":"32","author":"MHA Banna","year":"2022","unstructured":"Banna MHA, Sayeed A, Kundu S, Christopher E, Hasan MT, Begum MR, et al. The impact of the COVID-19 pandemic on the mental health of the adult population in Bangladesh: A nationwide cross-sectional study. Int J Environ Health Res 2022, 32: 850\u2013861.","journal-title":"Int J Environ Health Res"},{"key":"970_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41398-020-00913-3","volume":"10","author":"W Fu","year":"2020","unstructured":"Fu W, Wang C, Zou L, Guo Y, Lu Z, Yan S, et al. Psychological health, sleep quality, and coping styles to stress facing the COVID-19 in Wuhan, China. Transl Psychiatry 2020, 10: 225.","journal-title":"Transl Psychiatry"},{"key":"970_CR18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","volume":"397","author":"C Huang","year":"2021","unstructured":"Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study. Lancet 2021, 397: 220\u2013232.","journal-title":"Lancet"},{"key":"970_CR19","doi-asserted-by":"crossref","unstructured":"Wenham C, Smith J, Morgan R, Group GAC1W. COVID-19: The gendered impacts of the outbreak. Lancet 2020, 395: 846\u2013848.","DOI":"10.1016\/S0140-6736(20)30526-2"},{"key":"970_CR20","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/aogs.13925","volume":"99","author":"N Berthelot","year":"2020","unstructured":"Berthelot N, Lemieux R, Garon-Bissonnette J, Drouin-Maziade C, Martel \u00c9, Maziade M. Uptrend in distress and psychiatric symptomatology in pregnant women during the coronavirus disease 2019 pandemic. Acta Obstet Gynecol Scand 2020, 99: 848\u2013855.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"970_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jad.2020.07.126","volume":"277","author":"C Lebel","year":"2020","unstructured":"Lebel C, MacKinnon A, Bagshawe M, Tomfohr-Madsen L, Giesbrecht G. Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic. J Affect Disord 2020, 277: 5\u201313.","journal-title":"J Affect Disord"},{"key":"970_CR22","doi-asserted-by":"publisher","first-page":"e2014053","DOI":"10.1001\/jamanetworkopen.2020.14053","volume":"3","author":"L Shi","year":"2020","unstructured":"Shi L, Lu ZA, Que JY, Huang XL, Liu L, Ran MS, et al. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the coronavirus disease 2019 pandemic. JAMA Netw Open 2020, 3: e2014053.","journal-title":"JAMA Netw Open"},{"key":"970_CR23","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3109\/09540261.2010.492391","volume":"22","author":"G Parker","year":"2010","unstructured":"Parker G, Brotchie H. Gender differences in depression. Int Rev Psychiatry 2010, 22: 429\u2013436.","journal-title":"Int Rev Psychiatry"},{"key":"970_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2020.04.028","volume":"87","author":"C Wang","year":"2020","unstructured":"Wang C, Pan R, Wan X, Tan Y, Xu L, McIntyre RS, et al. A longitudinal study on the mental health of general population during the COVID-19 epidemic in China. Brain Behav Immun 2020, 87: 40\u201348.","journal-title":"Brain Behav Immun"},{"key":"970_CR25","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018, 392: 1789\u20131858."},{"key":"970_CR26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jad.2020.11.109","volume":"281","author":"Y Li","year":"2021","unstructured":"Li Y, Zhao J, Ma Z, McReynolds LS, Lin D, Chen Z, et al. Mental health among college students during the COVID-19 pandemic in China: A 2-wave longitudinal survey. J Affect Disord 2021, 281: 597\u2013604.","journal-title":"J Affect Disord"},{"key":"970_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1001\/jamapsychiatry.2021.3749","volume":"79","author":"P Zaninotto","year":"2022","unstructured":"Zaninotto P, Iob E, Demakakos P, Steptoe A. Immediate and longer-term changes in the mental health and well-being of older adults in England during the COVID-19 pandemic. JAMA Psychiatry 2022, 79: 151\u2013159.","journal-title":"JAMA Psychiatry"},{"key":"970_CR28","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.bbi.2020.07.037","volume":"89","author":"MG Mazza","year":"2020","unstructured":"Mazza MG, de Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I, et al. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun 2020, 89: 594\u2013600.","journal-title":"Brain Behav Immun"},{"key":"970_CR29","doi-asserted-by":"publisher","first-page":"113190","DOI":"10.1016\/j.psychres.2020.113190","volume":"291","author":"M Luo","year":"2020","unstructured":"Luo M, Guo L, Yu M, Jiang W, Wang H. The psychological and mental impact of coronavirus disease 2019 (COVID-19) on medical staff and general public - A systematic review and meta-analysis. Psychiatry Res 2020, 291: 113190.","journal-title":"Psychiatry Res"},{"key":"970_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbi.2020.05.038","volume":"88","author":"Q Guo","year":"2020","unstructured":"Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, et al. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study. Brain Behav Immun 2020, 88: 17\u201327.","journal-title":"Brain Behav Immun"},{"key":"970_CR31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10597-020-00728-y","volume":"57","author":"SMA Shah","year":"2021","unstructured":"Shah SMA, Mohammad D, Qureshi MFH, Abbas MZ, Aleem S. Prevalence, psychological responses and associated correlates of depression, anxiety and stress in a global population, during the coronavirus disease (COVID-19) pandemic. Community Ment Health J 2021, 57: 101\u2013110.","journal-title":"Community Ment Health J"},{"key":"970_CR32","doi-asserted-by":"publisher","first-page":"e0246454","DOI":"10.1371\/journal.pone.0246454","volume":"16","author":"Y Li","year":"2021","unstructured":"Li Y, Scherer N, Felix L, Kuper H. Prevalence of depression, anxiety and post-traumatic stress disorder in health care workers during the COVID-19 pandemic: A systematic review and meta-analysis. PLoS One 2021, 16: e0246454.","journal-title":"PLoS One"},{"key":"970_CR33","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jad.2020.07.085","volume":"276","author":"H Zhao","year":"2020","unstructured":"Zhao H, He X, Fan G, Li L, Huang Q, Qiu Q, et al. COVID-19 infection outbreak increases anxiety level of general public in China: Involved mechanisms and influencing factors. J Affect Disord 2020, 276: 446\u2013452.","journal-title":"J Affect Disord"},{"key":"970_CR34","doi-asserted-by":"publisher","first-page":"e0236562","DOI":"10.1371\/journal.pone.0236562","volume":"15","author":"JM Newby","year":"2020","unstructured":"Newby JM, O\u2019Moore K, Tang S, Christensen H, Faasse K. Acute mental health responses during the COVID-19 pandemic in Australia. PLoS One 2020, 15: e0236562.","journal-title":"PLoS One"},{"key":"970_CR35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jad.2020.06.049","volume":"276","author":"MS Islam","year":"2020","unstructured":"Islam MS, Ferdous MZ, Potenza MN. Panic and generalized anxiety during the COVID-19 pandemic among Bangladeshi people: An online pilot survey early in the outbreak. J Affect Disord 2020, 276: 30\u201337.","journal-title":"J Affect Disord"},{"key":"970_CR36","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1159\/000507639","volume":"89","author":"WR Zhang","year":"2020","unstructured":"Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, et al. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020, 89: 242\u2013250.","journal-title":"Psychother Psychosom"},{"key":"970_CR37","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000519586","volume":"6","author":"X Zheng","year":"2021","unstructured":"Zheng X, Guo Y, Ma W, Yang H, Luo L, Wen L, et al. A longitudinal study on the mental health of college students in Jinan during the peak stage of the COVID-19 epidemic and the society reopening. Biomed Hub 2021, 6: 102\u2013110.","journal-title":"Biomed Hub"},{"key":"970_CR38","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1017\/S0950268820001107","volume":"148","author":"CY Liu","year":"2020","unstructured":"Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, et al. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: A cross-sectional survey. Epidemiol Infect 2020, 148: e98.","journal-title":"Epidemiol Infect"},{"key":"970_CR39","doi-asserted-by":"publisher","first-page":"e924609","DOI":"10.12659\/MSM.924609","volume":"26","author":"L Lei","year":"2020","unstructured":"Lei L, Huang X, Zhang S, Yang J, Yang L, Xu M. Comparison of prevalence and associated factors of anxiety and depression among people affected by versus people unaffected by quarantine during the COVID-19 epidemic in southwestern China. Med Sci Monit 2020, 26: e924609.","journal-title":"Med Sci Monit"},{"key":"970_CR40","doi-asserted-by":"publisher","first-page":"e20328","DOI":"10.2196\/20328","volume":"22","author":"Y Guo","year":"2020","unstructured":"Guo Y, Cheng C, Zeng Y, Li Y, Zhu M, Yang W, et al. Mental health disorders and associated risk factors in quarantined adults during the COVID-19 outbreak in China: Cross-sectional study. J Med Internet Res 2020, 22: e20328.","journal-title":"J Med Internet Res"},{"key":"970_CR41","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.bbi.2020.04.049","volume":"88","author":"NWS Chew","year":"2020","unstructured":"Chew NWS, Lee GKH, Tan BYQ, Jing M, Goh Y, Ngiam NJH, et al. A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak. Brain Behav Immun 2020, 88: 559\u2013565.","journal-title":"Brain Behav Immun"},{"key":"970_CR42","doi-asserted-by":"publisher","first-page":"1964197","DOI":"10.1080\/20008198.2021.1964197","volume":"12","author":"A Lotzin","year":"2021","unstructured":"Lotzin A, Krause L, Acquarini E, Ajdukovic D, Ardino V, Arnberg F, et al. Risk and protective factors, stressors, and symptoms of adjustment disorder during the COVID-19 pandemic - First results of the ESTSS COVID-19 pan-European ADJUST study. Eur J Psychotraumatology 2021, 12: 1964197.","journal-title":"Eur J Psychotraumatology"},{"key":"970_CR43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1177\/0020764020927051","volume":"66","author":"S \u00d6zdin","year":"2020","unstructured":"\u00d6zdin S, Bayrak \u00d6zdin \u015e. Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender. Int J Soc Psychiatry 2020, 66: 504\u2013511.","journal-title":"Int J Soc Psychiatry"},{"key":"970_CR44","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bpsgos.2021.06.007","volume":"1","author":"B Holt-Gosselin","year":"2021","unstructured":"Holt-Gosselin B, Tozzi L, Ramirez CA, Gotlib IH, Williams LM. Coping strategies, neural structure, and depression and anxiety during the COVID-19 pandemic: A longitudinal study in a naturalistic sample spanning clinical diagnoses and subclinical symptoms. Biol Psychiatry Glob Open Sci 2021, 1: 261\u2013271.","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"970_CR45","doi-asserted-by":"publisher","first-page":"118311","DOI":"10.1016\/j.neuroimage.2021.118311","volume":"239","author":"T Salomon","year":"2021","unstructured":"Salomon T, Cohen A, Barazany D, Ben-Zvi G, Botvinik-Nezer R, Gera R, et al. Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown. NeuroImage 2021, 239: 118311.","journal-title":"NeuroImage"},{"key":"970_CR46","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.adolescence.2021.08.002","volume":"91","author":"D Jamieson","year":"2021","unstructured":"Jamieson D, Kannis-Dymand L, Beaudequin DA, Schwenn P, Shan Z, McLoughlin LT, et al. Can measures of sleep quality or white matter structural integrity predict level of worry or rumination in adolescents facing stressful situations? Lessons from the COVID-19 pandemic. J Adolesc 2021, 91: 110\u2013118.","journal-title":"J Adolesc"},{"key":"970_CR47","doi-asserted-by":"publisher","first-page":"111414","DOI":"10.1016\/j.pscychresns.2021.111414","volume":"319","author":"KJ Khorrami","year":"2022","unstructured":"Khorrami KJ, Manzler CA, Kreutzer KA, Gorka SM. Neural and self-report measures of sensitivity to uncertainty as predictors of COVID-related negative affect. Psychiatry Res Neuroimaging 2022, 319: 111414.","journal-title":"Psychiatry Res Neuroimaging"},{"key":"970_CR48","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.4103\/1673-5374.327361","volume":"17","author":"YY Du","year":"2022","unstructured":"Du YY, Zhao W, Zhou XL, Zeng M, Yang DH, Xie XZ, et al. Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: A resting-state functional magnetic resonance imaging study at 1-year follow-up. Neural Regen Res 2022, 17: 1576\u20131581.","journal-title":"Neural Regen Res"},{"key":"970_CR49","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jad.2021.09.107","volume":"297","author":"S Zhang","year":"2022","unstructured":"Zhang S, Cui J, Zhang Z, Wang Y, Liu R, Chen X, et al. Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic. J Affect Disord 2022, 297: 421\u2013429.","journal-title":"J Affect Disord"},{"key":"970_CR50","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1007\/s00259-020-05178-y","volume":"48","author":"A Kas","year":"2021","unstructured":"Kas A, Soret M, Pyatigoskaya N, Habert MO, Hesters A, Le Guennec L, et al. The cerebral network of COVID-19-related encephalopathy: A longitudinal voxel-based 18F-FDG-PET study. Eur J Nucl Med Mol Imaging 2021, 48: 2543\u20132557.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"970_CR51","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1176\/appi.ajp.2020.20070979","volume":"178","author":"L He","year":"2021","unstructured":"He L, Wei D, Yang F, Zhang J, Cheng W, Feng J, et al. Functional connectome prediction of anxiety related to the COVID-19 pandemic. Am J Psychiatry 2021, 178: 530\u2013540.","journal-title":"Am J Psychiatry"},{"key":"970_CR52","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.tics.2017.11.005","volume":"22","author":"D Badre","year":"2018","unstructured":"Badre D, Nee DE. Frontal cortex and the hierarchical control of behavior. Trends Cogn Sci 2018, 22: 170\u2013188.","journal-title":"Trends Cogn Sci"},{"key":"970_CR53","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.conb.2014.10.003","volume":"31","author":"DA McCormick","year":"2015","unstructured":"McCormick DA, McGinley MJ, Salkoff DB. Brain state dependent activity in the cortex and thalamus. Curr Opin Neurobiol 2015, 31: 133\u2013140.","journal-title":"Curr Opin Neurobiol"},{"key":"970_CR54","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.bandc.2015.07.002","volume":"110","author":"ET Rolls","year":"2016","unstructured":"Rolls ET. Functions of the anterior insula in taste, autonomic, and related functions. Brain Cogn 2016, 110: 4\u201319.","journal-title":"Brain Cogn"},{"key":"970_CR55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrn3857","volume":"16","author":"LQ Uddin","year":"2015","unstructured":"Uddin LQ. Salience processing and insular cortical function and dysfunction. Nat Rev Neurosci 2015, 16: 55\u201361.","journal-title":"Nat Rev Neurosci"},{"key":"970_CR56","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","volume":"19","author":"MA Ellul","year":"2020","unstructured":"Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol 2020, 19: 767\u2013783.","journal-title":"Lancet Neurol"},{"key":"970_CR57","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1152\/physrev.00039.2016","volume":"98","author":"R Dantzer","year":"2018","unstructured":"Dantzer R. Neuroimmune interactions: From the brain to the immune system and vice versa. Physiol Rev 2018, 98: 477\u2013504.","journal-title":"Physiol Rev"},{"key":"970_CR58","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1742-2094-10-43","volume":"10","author":"S Najjar","year":"2013","unstructured":"Najjar S, Pearlman DM, Alper K, Najjar A, Devinsky O. Neuroinflammation and psychiatric illness. J Neuroinflammation 2013, 10: 43.","journal-title":"J Neuroinflammation"},{"key":"970_CR59","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fpsyt.2020.00071","volume":"11","author":"F Benedetti","year":"2020","unstructured":"Benedetti F, Aggio V, Pratesi ML, Greco G, Furlan R. Neuroinflammation in bipolar depression. Front Psychiatry 2020, 11: 71.","journal-title":"Front Psychiatry"},{"key":"970_CR60","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mcn.2012.10.002","volume":"53","author":"KA Jones","year":"2013","unstructured":"Jones KA, Thomsen C. The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci 2013, 53: 52\u201362.","journal-title":"Mol Cell Neurosci"},{"key":"970_CR61","doi-asserted-by":"publisher","first-page":"7264","DOI":"10.1128\/JVI.00737-08","volume":"82","author":"J Netland","year":"2008","unstructured":"Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008, 82: 7264\u20137275.","journal-title":"J Virol"},{"key":"970_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.virusres.2007.02.014","volume":"133","author":"MJ Cameron","year":"2008","unstructured":"Cameron MJ, Bermejo-Martin JF, Danesh A, Muller MP, Kelvin DJ. Human immunopathogenesis of severe acute respiratory syndrome (SARS). Virus Res 2008, 133: 13\u201319.","journal-title":"Virus Res"},{"key":"970_CR63","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","volume":"80","author":"Q Ye","year":"2020","unstructured":"Ye Q, Wang B, Mao J. The pathogenesis and treatment of the \u2018Cytokine storm\u2019 in COVID-19. J Infect 2020, 80: 607\u2013613.","journal-title":"J Infect"},{"key":"970_CR64","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","volume":"39","author":"R Channappanavar","year":"2017","unstructured":"Channappanavar R, Perlman S. Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Semin Immunopathol 2017, 39: 529\u2013539.","journal-title":"Semin Immunopathol"},{"key":"970_CR65","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"C Huang","year":"2020","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China. Lancet 2020, 395: 497\u2013506.","journal-title":"China. Lancet"},{"key":"970_CR66","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/acps.12698","volume":"135","author":"CA K\u00f6hler","year":"2017","unstructured":"K\u00f6hler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, et al. Peripheral cytokine and chemokine alterations in depression: A meta-analysis of 82 studies. Acta Psychiatr Scand 2017, 135: 373\u2013387.","journal-title":"Acta Psychiatr Scand"},{"key":"970_CR67","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","volume":"70","author":"BJ Miller","year":"2011","unstructured":"Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry 2011, 70: 663\u2013671.","journal-title":"Biol Psychiatry"},{"key":"970_CR68","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/da.22790","volume":"35","author":"ME Renna","year":"2018","unstructured":"Renna ME, O\u2019Toole MS, Spaeth PE, Lekander M, Mennin DS. The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: A systematic review and meta-analysis. Depress Anxiety 2018, 35: 1081\u20131094.","journal-title":"Depress Anxiety"},{"key":"970_CR69","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pscychresns.2019.01.009","volume":"285","author":"S Poletti","year":"2019","unstructured":"Poletti S, Leone G, Hoogenboezem TA, Ghiglino D, Vai B, de Wit H, et al. Markers of neuroinflammation influence measures of cortical thickness in bipolar depression. Psychiatry Res Neuroimaging 2019, 285: 64\u201366.","journal-title":"Psychiatry Res Neuroimaging"},{"key":"970_CR70","doi-asserted-by":"publisher","first-page":"e986","DOI":"10.4088\/JCP.16m11310","volume":"78","author":"F Benedetti","year":"2017","unstructured":"Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, et al. Higher baseline proinflammatory cytokines mark poor antidepressant response in bipolar disorder. J Clin Psychiatry 2017, 78: e986\u2013e993.","journal-title":"J Clin Psychiatry"},{"key":"970_CR71","doi-asserted-by":"publisher","first-page":"672390","DOI":"10.3389\/fnut.2021.672390","volume":"8","author":"MA Ghannoum","year":"2021","unstructured":"Ghannoum MA, Ford M, Bonomo RA, Gamal A, McCormick TS. A microbiome-driven approach to combating depression during the COVID-19 pandemic. Front Nutr 2021, 8: 672390.","journal-title":"Front Nutr"},{"key":"970_CR72","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1007\/s11427-020-1847-7","volume":"64","author":"J Luo","year":"2021","unstructured":"Luo J, Liang S, Jin F. Gut microbiota in antiviral strategy from bats to humans: A missing link in COVID-19. Sci China Life Sci 2021, 64: 942\u2013956.","journal-title":"Sci China Life Sci"},{"key":"970_CR73","doi-asserted-by":"publisher","first-page":"e14197","DOI":"10.1111\/nmo.14197","volume":"34","author":"R Nakov","year":"2022","unstructured":"Nakov R, Dimitrova-Yurukova D, Snegarova V, Nakov V, Fox M, Heinrich H. Increased prevalence of gastrointestinal symptoms and disorders of gut-brain interaction during the COVID-19 pandemic: An Internet-based survey. Neurogastroenterol Motil 2022, 34: e14197.","journal-title":"Neurogastroenterol Motil"},{"key":"970_CR74","doi-asserted-by":"publisher","first-page":"11241","DOI":"10.1039\/D1FO01608C","volume":"12","author":"P Tian","year":"2021","unstructured":"Tian P, Chen Y, Qian X, Zou R, Zhu H, Zhao J, et al. Pediococcus acidilactici CCFM6432 mitigates chronic stress-induced anxiety and gut microbial abnormalities. Food Funct 2021, 12: 11241\u201311249.","journal-title":"Food Funct"},{"key":"970_CR75","doi-asserted-by":"publisher","first-page":"580827","DOI":"10.3389\/fpsyt.2020.580827","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Li X, Jiang J, Xu X, Wu J, Xu Y, et al. The effect of cognitive behavioral therapy on depression, anxiety, and stress in patients with COVID-19: A randomized controlled trial. Front Psychiatry 2020, 11: 580827.","journal-title":"Front Psychiatry"},{"key":"970_CR76","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1097\/AOG.0000000000004316","volume":"137","author":"RB Smith","year":"2021","unstructured":"Smith RB, Mahnert ND, Foote J, Saunders KT, Mourad J, Huberty J. Mindfulness effects in obstetric and gynecology patients during the coronavirus disease 2019 (COVID-19) pandemic: A randomized controlled trial. Obstet Gynecol 2021, 137: 1032\u20131040.","journal-title":"Obstet Gynecol"},{"key":"970_CR77","doi-asserted-by":"publisher","first-page":"101132","DOI":"10.1016\/j.ctcp.2020.101132","volume":"39","author":"K Liu","year":"2020","unstructured":"Liu K, Chen Y, Wu D, Lin R, Wang Z, Pan L. Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19. Complementary Ther Clin Pract 2020, 39: 101132.","journal-title":"Complementary Ther Clin Pract"},{"key":"970_CR78","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12888-021-03085-6","volume":"21","author":"M Shaygan","year":"2021","unstructured":"Shaygan M, Yazdani Z, Valibeygi A. The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: A pilot cluster randomized parallel-controlled trial. BMC Psychiatry 2021, 21: 93.","journal-title":"BMC Psychiatry"},{"key":"970_CR79","doi-asserted-by":"publisher","first-page":"573718","DOI":"10.3389\/fneur.2020.573718","volume":"11","author":"AF Baptista","year":"2020","unstructured":"Baptista AF, Baltar A, Okano AH, Moreira A, Campos ACP, Fernandes AM, et al. Applications of non-invasive neuromodulation for the management of disorders related to COVID-19. Front Neurol 2020, 11: 573718.","journal-title":"Front Neurol"},{"key":"970_CR80","doi-asserted-by":"publisher","first-page":"114086","DOI":"10.1016\/j.psychres.2021.114086","volume":"303","author":"JD Rosenblat","year":"2021","unstructured":"Rosenblat JD, Lipsitz O, di Vincenzo JD, Rodrigues NB, Kratiuk K, Subramaniapillai M, et al. Real-world effectiveness of repeated ketamine infusions for treatment resistant depression during the COVID-19 pandemic. Psychiatry Res 2021, 303: 114086.","journal-title":"Psychiatry Res"},{"key":"970_CR81","doi-asserted-by":"crossref","unstructured":"Khawam E, Khouli H, Pozuelo L. Treating acute anxiety in patients with COVID-19. Cleve Clin J Med 2020: 2020May14.","DOI":"10.3949\/ccjm.87a.ccc016"},{"key":"970_CR82","doi-asserted-by":"publisher","first-page":"110810","DOI":"10.1016\/j.biopha.2020.110810","volume":"132","author":"K Ma","year":"2020","unstructured":"Ma K, Wang X, Feng S, Xia X, Zhang H, Rahaman A, et al. From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors. Biomed Pharmacother 2020, 132: 110810.","journal-title":"Biomed Pharmacother"},{"key":"970_CR83","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bbi.2020.05.048","volume":"89","author":"N Vindegaard","year":"2020","unstructured":"Vindegaard N, Benros ME. COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav Immun 2020, 89: 531\u2013542.","journal-title":"Brain Behav Immun"},{"key":"970_CR84","doi-asserted-by":"publisher","first-page":"e26883","DOI":"10.2196\/26883","volume":"23","author":"Z Liu","year":"2021","unstructured":"Liu Z, Qiao D, Xu Y, Zhao W, Yang Y, Wen D, et al. The efficacy of computerized cognitive behavioral therapy for depressive and anxiety symptoms in patients with COVID-19: Randomized controlled trial. J Med Internet Res 2021, 23: e26883.","journal-title":"J Med Internet Res"},{"key":"970_CR85","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/brainsci11050579","volume":"11","author":"RL Perri","year":"2021","unstructured":"Perri RL, Castelli P, La Rosa C, Zucchi T, Onofri A. COVID-19, isolation, quarantine: On the efficacy of Internet-based eye movement desensitization and reprocessing (EMDR) and cognitive-behavioral therapy (CBT) for ongoing trauma. Brain Sci 2021, 11: 579.","journal-title":"Brain Sci"},{"key":"970_CR86","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1001\/jamapsychiatry.2020.0940","volume":"77","author":"E Axelsson","year":"2020","unstructured":"Axelsson E, Andersson E, Lj\u00f3tsson B, Bj\u00f6rkander D, Hedman-Lagerl\u00f6f M, Hedman-Lagerl\u00f6f E. Effect of Internet vs face-to-face cognitive behavior therapy for health anxiety: A randomized noninferiority clinical trial. JAMA Psychiatry 2020, 77: 915\u2013924.","journal-title":"JAMA Psychiatry"},{"key":"970_CR87","doi-asserted-by":"publisher","first-page":"e27039","DOI":"10.2196\/27039","volume":"9","author":"MA Fiol-DeRoque","year":"2021","unstructured":"Fiol-DeRoque MA, Serrano-Ripoll MJ, Jim\u00e9nez R, Zamanillo-Campos R, Y\u00e1\u00f1ez-Juan AM, Bennasar-Veny M, et al. A mobile phone-based intervention to reduce mental health problems in health care workers during the COVID-19 pandemic (PsyCovidApp): Randomized controlled trial. JMIR Mhealth Uhealth 2021, 9: e27039.","journal-title":"JMIR Mhealth Uhealth"},{"key":"970_CR88","doi-asserted-by":"publisher","first-page":"6450","DOI":"10.3390\/ijerph17186450","volume":"17","author":"A Matiz","year":"2020","unstructured":"Matiz A, Fabbro F, Paschetto A, Cantone D, Paolone AR, Crescentini C. Positive impact of mindfulness meditation on mental health of female teachers during the COVID-19 outbreak in Italy. Int J Environ Res Public Health 2020, 17: 6450.","journal-title":"Int J Environ Res Public Health"},{"key":"970_CR89","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.3390\/ijerph18115512","volume":"18","author":"A Accoto","year":"2021","unstructured":"Accoto A, Chiarella SG, Raffone A, Montano A, de Marco A, Mainiero F, et al. Beneficial effects of mindfulness-based stress reduction training on the well-being of a female sample during the first total lockdown due to COVID-19 pandemic in Italy. Int J Environ Res Public Health 2021, 18: 5512.","journal-title":"Int J Environ Res Public Health"},{"key":"970_CR90","doi-asserted-by":"publisher","first-page":"110260","DOI":"10.1016\/j.pnpbp.2021.110260","volume":"107","author":"C Malboeuf-Hurtubise","year":"2021","unstructured":"Malboeuf-Hurtubise C, L\u00e9ger-Goodes T, Mageau GA, Joussemet M, Herba C, Chadi N, et al. Philosophy for children and mindfulness during COVID-19: Results from a randomized cluster trial and impact on mental health in elementary school students. Prog Neuropsychopharmacol Biol Psychiatry 2021, 107: 110260. https:\/\/doi.org\/10.1016\/j.pnpbp.2021.110260.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"970_CR91","doi-asserted-by":"publisher","first-page":"e23185","DOI":"10.1097\/MD.0000000000023185","volume":"99","author":"CX Xiao","year":"2020","unstructured":"Xiao CX, Lin YJ, Lin RQ, Liu AN, Zhong GQ, Lan CF. Effects of progressive muscle relaxation training on negative emotions and sleep quality in COVID-19 patients. Medicine 2020, 99: e23185.","journal-title":"Medicine"},{"key":"970_CR92","doi-asserted-by":"publisher","first-page":"586355","DOI":"10.3389\/fpsyt.2020.586355","volume":"11","author":"X Kong","year":"2020","unstructured":"Kong X, Kong F, Zheng K, Tang M, Chen Y, Zhou J, et al. Effect of psychological-behavioral intervention on the depression and anxiety of COVID-19 patients. Front Psychiatry 2020, 11: 586355.","journal-title":"Front Psychiatry"},{"key":"970_CR93","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1631\/jzus.B2010013","volume":"21","author":"N Wei","year":"2020","unstructured":"Wei N, Huang BC, Lu SJ, Hu JB, Zhou XY, Hu CC, et al. Efficacy of Internet-based integrated intervention on depression and anxiety symptoms in patients with COVID-19. J Zhejiang Univ Sci B 2020, 21: 400\u2013404.","journal-title":"J Zhejiang Univ Sci B"},{"key":"970_CR94","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000520283","volume":"91","author":"RA Bryant","year":"2022","unstructured":"Bryant RA, Dawson KS, Keyan D, Azevedo S, Yadav S, Tran J, et al. Effectiveness of a videoconferencing-delivered psychological intervention for mental health problems during COVID-19: A proof-of-concept randomized clinical trial. Psychother Psychosom 2022, 91: 63\u201372.","journal-title":"Psychother Psychosom"},{"key":"970_CR95","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jad.2021.03.019","volume":"287","author":"H Li","year":"2021","unstructured":"Li H, Cui L, Li J, Liu Y, Chen Y. Comparative efficacy and acceptability of neuromodulation procedures in the treatment of treatment-resistant depression: A network meta-analysis of randomized controlled trials. J Affect Disord 2021, 287: 115\u2013124.","journal-title":"J Affect Disord"},{"key":"970_CR96","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2147\/PRBM.S275730","volume":"13","author":"AR Pinheiro Barcessat","year":"2020","unstructured":"Pinheiro Barcessat AR, Nolli Bittencourt M, Duarte Ferreira L, de Souza Neri E, Coelho Pereira JA, Bechelli F, et al. REAC cervicobrachial neuromodulation treatment of depression, anxiety, and stress during the COVID-19 pandemic. Psychol Res Behav Manag 2020, 13: 929\u2013937.","journal-title":"Psychol Res Behav Manag"},{"key":"970_CR97","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.brs.2020.07.004","volume":"13","author":"SK Shinjo","year":"2020","unstructured":"Shinjo SK, Brunoni AR, Okano AH, Tanaka C, Baptista AF. Transcranial direct current stimulation relieves the severe anxiety of a patient with COVID-19. Brain Stimul 2020, 13: 1352\u20131353.","journal-title":"Brain Stimul"},{"key":"970_CR98","doi-asserted-by":"publisher","first-page":"765370","DOI":"10.3389\/fnagi.2021.765370","volume":"13","author":"D Cappon","year":"2022","unstructured":"Cappon D, den Boer T, Jordan C, Yu W, Lo A, LaGanke N, et al. Safety and feasibility of tele-supervised home-based transcranial direct current stimulation for major depressive disorder. Front Aging Neurosci 2022, 13: 765370.","journal-title":"Front Aging Neurosci"},{"key":"970_CR99","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2165\/00007256-200939050-00003","volume":"39","author":"RE Rhodes","year":"2009","unstructured":"Rhodes RE, Warburton DER, Murray H. Characteristics of physical activity guidelines and their effect on adherence: A review of randomized trials. Sports Med 2009, 39: 355\u2013375.","journal-title":"Sports Med"},{"key":"970_CR100","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1111\/j.1742-1241.2010.02478.x","volume":"64","author":"L Alford","year":"2010","unstructured":"Alford L. What men should know about the impact of physical activity on their health. Int J Clin Pract 2010, 64: 1731\u20131734.","journal-title":"Int J Clin Pract"},{"key":"970_CR101","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1249\/MSS.0000000000001519","volume":"50","author":"C Wu","year":"2018","unstructured":"Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, et al. Beneficial effects of exercise pretreatment in a sporadic Alzheimer\u2019s rat model. Med Sci Sports Exerc 2018, 50: 945\u2013956.","journal-title":"Med Sci Sports Exerc"},{"key":"970_CR102","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1249\/MSS.0000000000002294","volume":"52","author":"C Wu","year":"2020","unstructured":"Wu C, Yang L, Li Y, Dong Y, Yang B, Tucker LD, et al. Effects of exercise training on anxious-depressive-like behavior in alzheimer rat. Med Sci Sports Exerc 2020, 52: 1456\u20131469.","journal-title":"Med Sci Sports Exerc"},{"key":"970_CR103","doi-asserted-by":"publisher","first-page":"613762","DOI":"10.3389\/fpsyt.2021.613762","volume":"12","author":"R Nagarathna","year":"2021","unstructured":"Nagarathna R, Anand A, Rain M, Srivastava V, Sivapuram MS, Kulkarni R, et al. Yoga practice is beneficial for maintaining healthy lifestyle and endurance under restrictions and stress imposed by lockdown during COVID-19 pandemic. Front Psychiatry 2021, 12: 613762.","journal-title":"Front Psychiatry"},{"key":"970_CR104","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1021\/es102947t","volume":"45","author":"J Thompson Coon","year":"2011","unstructured":"Thompson Coon J, Boddy K, Stein K, Whear R, Barton J, Depledge MH. Does participating in physical activity in outdoor natural environments have a greater effect on physical and mental wellbeing than physical activity indoors? A systematic review. Environ Sci Technol 2011, 45: 1761\u20131772.","journal-title":"Environ Sci Technol"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-022-00970-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-022-00970-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-022-00970-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T13:08:12Z","timestamp":1680613692000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-022-00970-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":104,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["970"],"URL":"https:\/\/doi.org\/10.1007\/s12264-022-00970-2","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"24 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}