{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:44:14Z","timestamp":1791981854325,"version":"4.4.0"},"reference-count":260,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Post-traumatic stress disorder (PTSD) is a psychiatric disorder caused by traumatic past experiences, rooted in the neurocircuits of fear memory formation. Memory processes include encoding, storing, and recalling to forgetting, suggesting the potential to erase fear memories through timely interventions. Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects. This review explores how fear memory may be erased, particularly focusing on the mnemonic phases of reconsolidation and extinction. Reconsolidation strengthens memory, while extinction weakens it. Interfering with memory reconsolidation could diminish the fear response. Alternatively, the extinction of acquired memory could reduce the fear memory response. This review summarizes experimental animal models of PTSD, examines the nature and epidemiology of reconsolidation to extinction, and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD. In sum, understanding how fear memory updates holds significant promise for PTSD treatment.<\/jats:p>","DOI":"10.1007\/s12264-025-01367-7","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T19:06:51Z","timestamp":1744225611000},"page":"1054-1084","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["How Fear Memory is Updated: From Reconsolidation to Extinction?"],"prefix":"10.1007","volume":"41","author":[{"given":"Jiahui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-9357","authenticated-orcid":false,"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"1367_CR1","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1017\/S0033291717000708","volume":"47","author":"KC Koenen","year":"2017","unstructured":"Koenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ. Posttraumatic stress disorder in the world mental health surveys. Psychol Med 2017, 47: 2260\u20132274.","journal-title":"Psychol Med"},{"key":"1367_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115304","volume":"326","author":"W Xiao","year":"2023","unstructured":"Xiao W, Liu X, Wang H, Huang Y, Dai Z, Si M, et al. Prevalence and risk for symptoms of PTSD among survivors of a COVID-19 infection. Psychiatry Res 2023, 326: 115304.","journal-title":"Psychiatry Res"},{"key":"1367_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41593-020-00748-7","volume":"24","author":"MJ Girgenti","year":"2021","unstructured":"Girgenti MJ, Wang J, Ji D, Cruz DA, Stein MB, et al. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nat Neurosci 2021, 24: 24\u201333.","journal-title":"Nat Neurosci"},{"key":"1367_CR4","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.2174\/1570159X19666210113152954","volume":"19","author":"F Chamaa","year":"2021","unstructured":"Chamaa F, Bahmad HF, Darwish B, Kobeissi JM, Hoballah M, Nassif SB, et al. PTSD in the COVID-19 era. Curr Neuropharmacol 2021, 19: 2164\u20132179.","journal-title":"Curr Neuropharmacol"},{"key":"1367_CR5","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1038\/s41380-021-01036-x","volume":"26","author":"K Yuan","year":"2021","unstructured":"Yuan K, Gong YM, Liu L, Sun YK, Tian SS, Wang YJ, et al. Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: A meta-analysis and systematic review. Mol Psychiatry 2021, 26: 4982\u20134998.","journal-title":"Mol Psychiatry"},{"key":"1367_CR6","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/S0140-6736(20)30309-3","volume":"395","author":"Y Bao","year":"2020","unstructured":"Bao Y, Sun Y, Meng S, Shi J, Lu L. 2019-nCoV epidemic: Address mental health care to empower society. Lancet 2020, 395: e37\u2013e38.","journal-title":"Lancet"},{"key":"1367_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2021.803315","volume":"3","author":"A Khanna","year":"2021","unstructured":"Khanna A, Jones GB. Envisioning post-pandemic digital neurological, psychiatric and mental health care. Front Digit Health 2021, 3: 803315.","journal-title":"Front Digit Health"},{"key":"1367_CR8","doi-asserted-by":"crossref","unstructured":"Guideline Development Panel for the Treatment of Ptsd in Adults AcPA. Summary of the clinical practice guideline for the treatment of posttraumatic stress disorder (PTSD) in adults. Am Psychol 2019, 74: 596\u2013607.","DOI":"10.1037\/amp0000473"},{"key":"1367_CR9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000505977","volume":"89","author":"MJ van Gelderen","year":"2020","unstructured":"van Gelderen MJ, Nijdam MJ, Haagen JFG, Vermetten E. Interactive motion-assisted exposure therapy for veterans with treatment-resistant posttraumatic stress disorder: A randomized controlled trial. Psychother Psychosom 2020, 89: 215\u2013227.","journal-title":"Psychother Psychosom"},{"key":"1367_CR10","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.psychres.2017.01.034","volume":"249","author":"RM Post","year":"2017","unstructured":"Post RM, Kegan R. Prevention of recurrent affective episodes using extinction training in the reconsolidation window: A testable psychotherapeutic strategy. Psychiatry Res 2017, 249: 327\u2013336.","journal-title":"Psychiatry Res"},{"key":"1367_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2019.102156","volume":"68","author":"BO Rothbaum","year":"2019","unstructured":"Rothbaum BO, McSweeney LB. Patients need to remain in treatment for PTSD to receive the full benefit. J Anxiety Disord 2019, 68: 102156.","journal-title":"J Anxiety Disord"},{"key":"1367_CR12","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1037\/ser0000714","volume":"20","author":"SY Wells","year":"2023","unstructured":"Wells SY, Morland LA, Hurst S, Jackson GL, Kehle-Forbes SM, Jaime K, et al. Veterans\u2019 reasons for dropping out of prolonged exposure therapy across three delivery modalities: A qualitative examination. Psychol Serv 2023, 20: 483\u2013495.","journal-title":"Psychol Serv"},{"key":"1367_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12888-023-05460-x","volume":"24","author":"SK Brooks","year":"2024","unstructured":"Brooks SK, Greenberg N. Recurrence of post-traumatic stress disorder: Systematic review of definitions, prevalence and predictors. BMC Psychiatry 2024, 24: 37.","journal-title":"BMC Psychiatry"},{"key":"1367_CR14","doi-asserted-by":"publisher","first-page":"12403","DOI":"10.1073\/pnas.210381897","volume":"97","author":"H Okano","year":"2000","unstructured":"Okano H, Hirano T, Balaban E. Learning and memory. Proc Natl Acad Sci U S A 2000, 97: 12403\u201312404.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1367_CR15","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.3389\/fpsyg.2019.02523","volume":"10","author":"G Zlotnik","year":"2019","unstructured":"Zlotnik G, Vansintjan A. Memory: An extended definition. Front Psychol 2019, 10: 2523.","journal-title":"Front Psychol"},{"key":"1367_CR16","unstructured":"Squire L, Kandel E. Memory: From mind to molecules. Nat Med, 2003"},{"key":"1367_CR17","unstructured":"M\u00fcller GE, Pilzecker A. Experimentelle Beitr\u00e4ge Zur Lehre Vom Ged\u00e4chtniss [German]. 1 ed: J. A. Barth, Leipzig, 1900."},{"key":"1367_CR18","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/35021052","volume":"406","author":"K Nader","year":"2000","unstructured":"Nader K, Schafe GE, Le Doux JE. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 2000, 406: 722\u2013726.","journal-title":"Nature"},{"key":"1367_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nrn1607","volume":"6","author":"PW Frankland","year":"2005","unstructured":"Frankland PW, Bontempi B. The organization of recent and remote memories. Nat Rev Neurosci 2005, 6: 119\u2013130.","journal-title":"Nat Rev Neurosci"},{"key":"1367_CR20","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.160.3827.554","volume":"160","author":"JR Misanin","year":"1968","unstructured":"Misanin JR, Miller RR, Lewis DJ. Retrograde Amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science 1968, 160: 554\u2013555.","journal-title":"Science"},{"key":"1367_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1126\/science.159.3811.219","volume":"159","author":"AM Schneider","year":"1968","unstructured":"Schneider AM, Sherman W. Amnesia: A function of the temporal relation of footshock to electroconvulsive shock. Science 1968, 159: 219\u2013221.","journal-title":"Science"},{"key":"1367_CR22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1037\/h0028177","volume":"76","author":"DJ Lewis","year":"1969","unstructured":"Lewis DJ. Sources of experimental Amnesia. Psychol Rev 1969, 76: 461\u2013472.","journal-title":"Psychol Rev"},{"key":"1367_CR23","doi-asserted-by":"publisher","first-page":"R746","DOI":"10.1016\/j.cub.2013.06.046","volume":"23","author":"CM Alberini","year":"2013","unstructured":"Alberini CM, LeDoux JE. Memory reconsolidation. Curr Biol 2013, 23: R746\u2013R750.","journal-title":"Curr Biol"},{"key":"1367_CR24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1037\/0033-2909.114.1.80","volume":"114","author":"ME Bouton","year":"1993","unstructured":"Bouton ME. Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol Bull 1993, 114: 80\u201399.","journal-title":"Psychol Bull"},{"key":"1367_CR25","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1126\/science.1086881","volume":"301","author":"M Eisenberg","year":"2003","unstructured":"Eisenberg M, Kobilo T, Berman DE, Dudai Y. Stability of retrieved memory: Inverse correlation with trace dominance. Science 2003, 301: 1102\u20131104.","journal-title":"Science"},{"key":"1367_CR26","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.neuron.2014.09.029","volume":"84","author":"Y Lu","year":"2014","unstructured":"Lu Y, Sun XD, Hou FQ, Bi LL, Yin DM, Liu F, et al. Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron 2014, 84: 835\u2013846.","journal-title":"Neuron"},{"key":"1367_CR27","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75703","volume":"12","author":"M Kintscher","year":"2023","unstructured":"Kintscher M, Kochubey O, Schneggenburger R. A striatal circuit balances learned fear in the presence and absence of sensory cues. Elife 2023, 12: e75703.","journal-title":"Elife"},{"key":"1367_CR28","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nrn3945","volume":"16","author":"P Tovote","year":"2015","unstructured":"Tovote P, Fadok JP, L\u00fcthi A. Neuronal circuits for fear and anxiety. Nat Rev Neurosci 2015, 16: 317\u2013331.","journal-title":"Nat Rev Neurosci"},{"key":"1367_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1080\/15622975.2022.2027010","volume":"23","author":"LK Pedraza","year":"2022","unstructured":"Pedraza LK, Sierra RO, de Oliveira Alvares L. Systems consolidation and fear memory generalisation as a potential target for trauma-related disorders. World J Biol Psychiatry 2022, 23: 653\u2013665.","journal-title":"World J Biol Psychiatry"},{"key":"1367_CR30","doi-asserted-by":"publisher","first-page":"15057","DOI":"10.1038\/nrdp.2015.57","volume":"1","author":"R Yehuda","year":"2015","unstructured":"Yehuda R, Hoge CW, McFarlane AC, Vermetten E, Lanius RA, Nievergelt CM, et al. Post-traumatic stress disorder. Nat Rev Dis Primers 2015, 1: 15057.","journal-title":"Nat Rev Dis Primers"},{"key":"1367_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41586-019-1433-7","volume":"572","author":"EA Phelps","year":"2019","unstructured":"Phelps EA, Hofmann SG. Memory editing from science fiction to clinical practice. Nature 2019, 572: 43\u201350.","journal-title":"Nature"},{"key":"1367_CR32","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1126\/science.1167975","volume":"324","author":"MH Monfils","year":"2009","unstructured":"Monfils MH, Cowansage KK, Klann E, LeDoux JE. Extinction-reconsolidation boundaries: Key to persistent attenuation of fear memories. Science 2009, 324: 951\u2013955.","journal-title":"Science"},{"key":"1367_CR33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nature08637","volume":"463","author":"D Schiller","year":"2010","unstructured":"Schiller D, Monfils MH, Raio CM, Johnson DC, Ledoux JE, Phelps EA. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 2010, 463: 49\u201353.","journal-title":"Nature"},{"key":"1367_CR34","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cell.2013.12.020","volume":"156","author":"J Gr\u00e4ff","year":"2014","unstructured":"Gr\u00e4ff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 2014, 156: 261\u2013276.","journal-title":"Cell"},{"key":"1367_CR35","doi-asserted-by":"publisher","first-page":"5206","DOI":"10.1073\/pnas.1601440113","volume":"13","author":"T Hardwicke","year":"2016","unstructured":"Hardwicke T, Taqi M, Shanks D. Postretrieval new learning does not reliably induce human memory updating via reconsolidation. Proc Natl Acad Sci U S A 2016, 13: 5206\u20135211.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1367_CR36","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cortex.2020.03.031","volume":"129","author":"A Chalkia","year":"2020","unstructured":"Chalkia A, Van Oudenhove L, Beckers T. Preventing the return of fear in humans using reconsolidation update mechanisms: A verification report of Schiller et al. (2010). Cortex 2020, 129: 510\u2013525.","journal-title":"Cortex"},{"key":"1367_CR37","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/jpm11040241","volume":"11","author":"M Costanzi","year":"2021","unstructured":"Costanzi M, Cianfanelli B, Santirocchi A, Lasaponara S, Spataro P, Rossi-Arnaud C, et al. Forgetting unwanted memories: Active forgetting and implications for the development of psychological disorders. J Pers Med 2021, 11: 241.","journal-title":"J Pers Med"},{"key":"1367_CR38","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neuron.2011.06.037","volume":"71","author":"S McKenzie","year":"2011","unstructured":"McKenzie S, Eichenbaum H. Consolidation and reconsolidation: Two lives of memories? Neuron 2011, 71: 224\u2013233.","journal-title":"Neuron"},{"key":"1367_CR39","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1126\/science.1223006","volume":"337","author":"T Agren","year":"2012","unstructured":"Agren T, Engman J, Frick A, Bj\u00f6rkstrand J, Larsson EM, Furmark T, et al. Disruption of reconsolidation erases a fear memory trace in the human amygdala. Science 2012, 337: 1550\u20131552.","journal-title":"Science"},{"key":"1367_CR40","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1016\/j.cub.2020.06.091","volume":"30","author":"S Borgomaneri","year":"2020","unstructured":"Borgomaneri S, Battaglia S, Garofalo S, Tortora F, Avenanti A, di Pellegrino G. State-dependent TMS over prefrontal cortex disrupts fear-memory reconsolidation and prevents the return of fear. Curr Biol 2020, 30: 3672-3679.e4.","journal-title":"Curr Biol"},{"key":"1367_CR41","doi-asserted-by":"publisher","first-page":"136","DOI":"10.5214\/ans.0972-7531.1017309","volume":"17","author":"PI Pavlov","year":"2010","unstructured":"Pavlov PI. Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex. Ann Neurosci 2010, 17: 136\u2013141.","journal-title":"Ann Neurosci"},{"key":"1367_CR42","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1038\/npp.2011.87","volume":"36","author":"CH Yang","year":"2011","unstructured":"Yang CH, Huang CC, Hsu KS. Generalization of fear inhibition by disrupting hippocampal protein synthesis-dependent reconsolidation process. Neuropsychopharmacology 2011, 36: 1992\u20132008.","journal-title":"Neuropsychopharmacology"},{"key":"1367_CR43","doi-asserted-by":"publisher","first-page":"4273280","DOI":"10.1155\/2016\/4273280","volume":"2016","author":"AC Alvarez-Dieppa","year":"2016","unstructured":"Alvarez-Dieppa AC, Griffin K, Cavalier S, McIntyre CK. Vagus nerve stimulation enhances extinction of conditioned fear in rats and modulates arc protein, CaMKII, and GluN2B-containing NMDA receptors in the basolateral amygdala. Neural Plast 2016, 2016: 4273280.","journal-title":"Neural Plast"},{"key":"1367_CR44","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11571-021-09708-8","volume":"16","author":"G Tasaka","year":"2022","unstructured":"Tasaka G, Ide Y, Tsukada M, Aihara T. Multimodal cortico-cortical associations induced by fear and sensory conditioning in the guinea pig. Cogn Neurodyn 2022, 16: 283\u2013296.","journal-title":"Cogn Neurodyn"},{"key":"1367_CR45","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3389\/fphar.2016.00493","volume":"7","author":"C Song","year":"2016","unstructured":"Song C, Stevenson CW, Guimaraes FS, Lee JLC. Bidirectional effects of cannabidiol on contextual fear memory extinction. Front Pharmacol 2016, 7: 493.","journal-title":"Front Pharmacol"},{"key":"1367_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110161","volume":"108","author":"JM Alfei","year":"2021","unstructured":"Alfei JM, De Gruy H, De Bundel D, Luyten L, Beckers T. Apparent reconsolidation interference without generalized Amnesia. Prog Neuropsychopharmacol Biol Psychiatry 2021, 108: 110161.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1367_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.113766","volume":"422","author":"M Mugnaini","year":"2022","unstructured":"Mugnaini M, Alfei JM, Bueno AM, Ferrer Monti RI, Urcelay GP. Fear memory modulation by incentive down and up-shifts. Behav Brain Res 2022, 422: 113766.","journal-title":"Behav Brain Res"},{"key":"1367_CR48","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3389\/fphar.2017.00415","volume":"8","author":"FE Valiati","year":"2017","unstructured":"Valiati FE, Vasconcelos M, Lichtenfels M, Petry FS, de Almeida RMM, Schwartsmann G, et al. Administration of a histone deacetylase inhibitor into the basolateral amygdala enhances memory consolidation, delays extinction, and increases hippocampal BDNF levels. Front Pharmacol 2017, 8: 415.","journal-title":"Front Pharmacol"},{"key":"1367_CR49","doi-asserted-by":"publisher","first-page":"11078","DOI":"10.1523\/JNEUROSCI.1223-09.2009","volume":"29","author":"E Ganon-Elazar","year":"2009","unstructured":"Ganon-Elazar E, Akirav I. Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci 2009, 29: 11078\u201311088.","journal-title":"J Neurosci"},{"key":"1367_CR50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02736","volume":"3","author":"H Fukushima","year":"2014","unstructured":"Fukushima H, Zhang Y, Archbold G, Ishikawa R, Nader K, Kida S. Enhancement of fear memory by retrieval through reconsolidation. Elife 2014, 3: e02736.","journal-title":"Elife"},{"key":"1367_CR51","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.nlm.2018.09.010","volume":"155","author":"TL Gilman","year":"2018","unstructured":"Gilman TL, Dutta S, Adkins JM, Cecil CA, Jasnow AM. Basolateral amygdala Thy1-expressing neurons facilitate the inhibition of contextual fear during consolidation, reconsolidation, and extinction. Neurobiol Learn Mem 2018, 155: 498\u2013507.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s003590050328","volume":"184","author":"P Pereyra","year":"1999","unstructured":"Pereyra P, Saraco M, Maldonado H. Decreased response or alternative defensive strategies in escape: Two different types of long-term memory in the crab Chasmagnathus. J Comp Physiol A 1999, 184: 301\u2013310.","journal-title":"J Comp Physiol A"},{"key":"1367_CR53","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0006-3223(95)00088-7","volume":"39","author":"RS Pynoos","year":"1996","unstructured":"Pynoos RS, Ritzmann RF, Steinberg AM, Goenjian A, Prisecaru I. A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders. Biol Psychiatry 1996, 39: 129\u2013134.","journal-title":"Biol Psychiatry"},{"key":"1367_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.809271","volume":"12","author":"R Martinho","year":"2022","unstructured":"Martinho R, Seixas R, Azevedo M, Oliveira A, Serr\u00e3o P, Moreira-Rodrigues M. Sotalol treatment may interfere with retrieval, expression, and\/or reconsolidation processes thus disrupting traumatic memories in a post-traumatic stress disorder mice model. Front Pharmacol 2022, 12: 809271.","journal-title":"Front Pharmacol"},{"key":"1367_CR55","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.neuropharm.2018.03.029","volume":"135","author":"LB Burhans","year":"2018","unstructured":"Burhans LB, Smith-Bell CA, Schreurs BG. Propranolol produces short-term facilitation of extinction in a rabbit model of post-traumatic stress disorder. Neuropharmacology 2018, 135: 386\u2013398.","journal-title":"Neuropharmacology"},{"key":"1367_CR56","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1126\/science.182.4116.1039","volume":"182","author":"HM Pinsker","year":"1973","unstructured":"Pinsker HM, Hening WA, Carew TJ, Kandel ER. Long-term sensitization of a defensive withdrawal reflex in Aplysia. Science 1973, 182: 1039\u20131042.","journal-title":"Science"},{"key":"1367_CR57","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1101\/lm.4.4.356","volume":"4","author":"T Sekiguchi","year":"1997","unstructured":"Sekiguchi T, Yamada A, Suzuki H. Reactivation-dependent changes in memory states in the terrestrial slug Limax flavus. Learn Mem 1997, 4: 356\u2013364.","journal-title":"Learn Mem"},{"key":"1367_CR58","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0896-6273(03)00352-0","volume":"38","author":"ME Pedreira","year":"2003","unstructured":"Pedreira ME, Maldonado H. Protein synthesis subserves reconsolidation or extinction depending on reminder duration. Neuron 2003, 38: 863\u2013869.","journal-title":"Neuron"},{"key":"1367_CR59","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1111\/j.1460-9568.2004.03818.x","volume":"20","author":"M Eisenberg","year":"2004","unstructured":"Eisenberg M, Dudai Y. Reconsolidation of fresh, remote, and extinguished fear memory in Medaka: Old fears don\u2019t die. Eur J Neurosci 2004, 20: 3397\u20133403.","journal-title":"Eur J Neurosci"},{"key":"1367_CR60","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1046\/j.1460-9568.2002.02023.x","volume":"15","author":"KV Anokhin","year":"2002","unstructured":"Anokhin KV, Tiunova AA, Rose SPR. Reminder effects\u2014reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive-avoidance task in young chicks. Eur J Neurosci 2002, 15: 1759\u20131765.","journal-title":"Eur J Neurosci"},{"key":"1367_CR61","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.anbehav.2016.10.009","volume":"122","author":"BC Jones","year":"2016","unstructured":"Jones BC, Bebus SE, Ferguson SM, Bateman P, Schoech S. The glucocorticoid response in a free-living bird predicts whether long-lasting memories fade or strengthen with time. Anim Behav 2016, 122: 157\u2013168.","journal-title":"Anim Behav"},{"key":"1367_CR62","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1523\/JNEUROSCI.3273-17.2018","volume":"38","author":"E Merlo","year":"2018","unstructured":"Merlo E, Milton AL, Everitt BJ. A novel retrieval-dependent memory process revealed by the arrest of ERK1\/2 activation in the basolateral amygdala. J Neurosci 2018, 38: 3199\u20133207.","journal-title":"J Neurosci"},{"key":"1367_CR63","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.cub.2020.02.083","volume":"30","author":"PSB Finnie","year":"2020","unstructured":"Finnie PSB, Nader K. Amyloid beta secreted during consolidation prevents memory malleability. Curr Biol 2020, 30: 1934-1940.e4.","journal-title":"Curr Biol"},{"key":"1367_CR64","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41586-021-03593-1","volume":"594","author":"KM Hagihara","year":"2021","unstructured":"Hagihara KM, Bukalo O, Zeller M, Aksoy-Aksel A, Karalis N, Limoges A, et al. Intercalated amygdala clusters orchestrate a switch in fear state. Nature 2021, 594: 403\u2013407.","journal-title":"Nature"},{"key":"1367_CR65","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1038\/s41467-020-18985-6","volume":"11","author":"KM McCullough","year":"2020","unstructured":"McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, et al. Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun 2020, 11: 5180.","journal-title":"Nat Commun"},{"key":"1367_CR66","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.1038\/s41467-022-32246-8","volume":"13","author":"SL Grella","year":"2022","unstructured":"Grella SL, Fortin AH, Ruesch E, Bladon JH, Reynolds LF, Gross A, et al. Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear. Nat Commun 2022, 13: 4733.","journal-title":"Nat Commun"},{"key":"1367_CR67","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1101\/lm.051615.120","volume":"27","author":"TR da Silva","year":"2020","unstructured":"da Silva TR, Sohn JMB, Andreatini R, Stern CA. The role of prelimbic and anterior cingulate cortices in fear memory reconsolidation and persistence depends on the memory age. Learn Mem 2020, 27: 292\u2013300.","journal-title":"Learn Mem"},{"key":"1367_CR68","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1038\/s41593-019-0528-7","volume":"22","author":"ND Hartley","year":"2019","unstructured":"Hartley ND, Gaulden AD, B\u00e1ldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, et al. Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states. Nat Neurosci 2019, 22: 2000\u20132012.","journal-title":"Nat Neurosci"},{"key":"1367_CR69","doi-asserted-by":"publisher","first-page":"5540","DOI":"10.1038\/s41467-022-33241-9","volume":"13","author":"Q Wang","year":"2022","unstructured":"Wang Q, Zhu JJ, Wang L, Kan YP, Liu YM, Wu YJ, et al. Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways. Nat Commun 2022, 13: 5540.","journal-title":"Nat Commun"},{"key":"1367_CR70","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41398-020-01043-6","volume":"10","author":"AP Swiercz","year":"2020","unstructured":"Swiercz AP, Iyer L, Yu Z, Edwards A, Prashant NM, Nguyen BN, et al. Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory. Transl Psychiatry 2020, 10: 363.","journal-title":"Transl Psychiatry"},{"key":"1367_CR71","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1523\/JNEUROSCI.1854-20.2020","volume":"41","author":"H Fukushima","year":"2021","unstructured":"Fukushima H, Zhang Y, Kida S. Active transition of fear memory phase from reconsolidation to extinction through ERK-mediated prevention of reconsolidation. J Neurosci 2021, 41: 1288\u20131300.","journal-title":"J Neurosci"},{"key":"1367_CR72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0166-2236(02)00042-5","volume":"26","author":"K Nader","year":"2003","unstructured":"Nader K. Memory traces unbound. Trends Neurosci 2003, 26: 65\u201372.","journal-title":"Trends Neurosci"},{"key":"1367_CR73","doi-asserted-by":"publisher","first-page":"8305","DOI":"10.1523\/JNEUROSCI.22-18-08305.2002","volume":"22","author":"ME Pedreira","year":"2002","unstructured":"Pedreira ME, P\u00e9rez-Cuesta LM, Maldonado H. Reactivation and reconsolidation of long-term memory in the crab Chasmagnathus: Protein synthesis requirement and mediation by NMDA-type glutamatergic receptors. J Neurosci 2002, 22: 8305\u20138311.","journal-title":"J Neurosci"},{"key":"1367_CR74","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1111\/j.1460-9568.2007.05621.x","volume":"25","author":"XC Jin","year":"2007","unstructured":"Jin XC, Lu YF, Yang XF, Ma L, Li BM. Glucocorticoid receptors in the basolateral nucleus of amygdala are required for postreactivation reconsolidation of auditory fear memory. Eur J Neurosci 2007, 25: 3702\u20133712.","journal-title":"Eur J Neurosci"},{"key":"1367_CR75","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.nlm.2010.04.007","volume":"94","author":"K Rehberg","year":"2010","unstructured":"Rehberg K, Bergado-Acosta JR, Koch JC, Stork O. Disruption of fear memory consolidation and reconsolidation by actin filament arrest in the basolateral amygdala. Neurobiol Learn Mem 2010, 94: 117\u2013126.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR76","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1101\/lm.801108","volume":"15","author":"TW Bredy","year":"2008","unstructured":"Bredy TW, Barad M. The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear. Learn Mem 2008, 15: 39\u201345.","journal-title":"Learn Mem"},{"key":"1367_CR77","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1101\/lm.2243411","volume":"18","author":"SA Maddox","year":"2011","unstructured":"Maddox SA, Schafe GE. Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory. Learn Mem 2011, 18: 579\u2013593.","journal-title":"Learn Mem"},{"key":"1367_CR78","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1038\/npp.2017.23","volume":"42","author":"JL Kwapis","year":"2017","unstructured":"Kwapis JL, Jarome TJ, Ferrara NC, Helmstetter FJ. Updating procedures can reorganize the neural circuit supporting a fear memory. Neuropsychopharmacology 2017, 42: 1688\u20131697.","journal-title":"Neuropsychopharmacology"},{"key":"1367_CR79","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41586-023-05910-2","volume":"616","author":"T Yang","year":"2023","unstructured":"Yang T, Yu K, Zhang X, Xiao X, Chen X, Fu Y, et al. Plastic and stimulus-specific coding of salient events in the central amygdala. Nature 2023, 616: 510\u2013519.","journal-title":"Nature"},{"key":"1367_CR80","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/nn.4414","volume":"19","author":"J Kim","year":"2016","unstructured":"Kim J, Pignatelli M, Xu S, Itohara S, Tonegawa S. Antagonistic negative and positive neurons of the basolateral amygdala. Nat Neurosci 2016, 19: 1636\u20131646.","journal-title":"Nat Neurosci"},{"key":"1367_CR81","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.biopsych.2021.12.018","volume":"91","author":"J Liu","year":"2022","unstructured":"Liu J, Totty MS, Melissari L, Bayer H, Maren S. Convergent coding of recent and remote fear memory in the basolateral amygdala. Biol Psychiatry 2022, 91: 832\u2013840.","journal-title":"Biol Psychiatry"},{"key":"1367_CR82","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57010","volume":"9","author":"J Haubrich","year":"2020","unstructured":"Haubrich J, Bernabo M, Nader K. Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation. Elife 2020, 9: e57010.","journal-title":"Elife"},{"key":"1367_CR83","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.tics.2022.09.005","volume":"26","author":"J Wang","year":"2022","unstructured":"Wang J, Tambini A, Lapate RC. The Tie that binds: Temporal coding and adaptive emotion. Trends Cogn Sci 2022, 26: 1103\u20131118.","journal-title":"Trends Cogn Sci"},{"key":"1367_CR84","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuron.2021.12.012","volume":"110","author":"N Nyberg","year":"2022","unstructured":"Nyberg N, Duvelle \u00c9, Barry C, Spiers HJ. Spatial goal coding in the hippocampal formation. Neuron 2022, 110: 394\u2013422.","journal-title":"Neuron"},{"key":"1367_CR85","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/s41583-019-0150-4","volume":"20","author":"AP Yonelinas","year":"2019","unstructured":"Yonelinas AP, Ranganath C, Ekstrom AD, Wiltgen BJ. A contextual binding theory of episodic memory: Systems consolidation reconsidered. Nat Rev Neurosci 2019, 20: 364\u2013375.","journal-title":"Nat Rev Neurosci"},{"key":"1367_CR86","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1016\/j.cub.2020.04.040","volume":"30","author":"R Zinn","year":"2020","unstructured":"Zinn R, Leake J, Krasne FB, Corbit LH, Fanselow MS, Vissel B. Maladaptive properties of context-impoverished memories. Curr Biol 2020, 30: 2300-2311.e6.","journal-title":"Curr Biol"},{"key":"1367_CR87","first-page":"841","volume":"27","author":"V Lux","year":"2017","unstructured":"Lux V, Masseck OA, Herlitze S, Sauvage MM. Optogenetic destabilization of the memory trace in CA1: Insights into reconsolidation and retrieval processes. Cereb Cortex 2017, 27: 841\u2013851.","journal-title":"Cereb Cortex"},{"key":"1367_CR88","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nn.4443","volume":"20","author":"X Ye","year":"2017","unstructured":"Ye X, Kapeller-Libermann D, Travaglia A, Carmen Inda M, Alberini CM. Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories. Nat Neurosci 2017, 20: 52\u201361.","journal-title":"Nat Neurosci"},{"key":"1367_CR89","doi-asserted-by":"publisher","first-page":"12157","DOI":"10.1038\/s41598-019-48340-9","volume":"9","author":"V de la Fuente","year":"2019","unstructured":"de la Fuente V, Medina C, Falasco G, Urrutia L, Kravitz AV, Urbano FJ, et al. The lateral neocortex is critical for contextual fear memory reconsolidation. Sci Rep 2019, 9: 12157.","journal-title":"Sci Rep"},{"key":"1367_CR90","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1523\/JNEUROSCI.21-06-02186.2001","volume":"21","author":"J Hall","year":"2001","unstructured":"Hall J, Thomas KL, Everitt BJ. Cellular imaging of zif268 expression in the hippocampus and amygdala during contextual and cued fear memory retrieval: Selective activation of hippocampal CA1 neurons during the recall of contextual memories. J Neurosci 2001, 21: 2186\u20132193.","journal-title":"J Neurosci"},{"key":"1367_CR91","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1046\/j.0953-816x.2001.01531.x","volume":"13","author":"J Hall","year":"2001","unstructured":"Hall J, Thomas KL, Everitt BJ. Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala. Eur J Neurosci 2001, 13: 1453\u20131458.","journal-title":"Eur J Neurosci"},{"key":"1367_CR92","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1046\/j.1460-9568.2002.02247.x","volume":"16","author":"KL Thomas","year":"2002","unstructured":"Thomas KL, Hall J, Everitt BJ. Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memory. Eur J Neurosci 2002, 16: 1789\u20131796.","journal-title":"Eur J Neurosci"},{"key":"1367_CR93","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1523\/JNEUROSCI.4639-08.2009","volume":"29","author":"N Mamiya","year":"2009","unstructured":"Mamiya N, Fukushima H, Suzuki A, Matsuyama Z, Homma S, Frankland PW, et al. Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory. J Neurosci 2009, 29: 402\u2013413.","journal-title":"J Neurosci"},{"key":"1367_CR94","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1523\/JNEUROSCI.4707-04.2005","volume":"25","author":"LSJ von Hertzen","year":"2005","unstructured":"von Hertzen LSJ, Giese KP. Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. J Neurosci 2005, 25: 1935\u20131942.","journal-title":"J Neurosci"},{"key":"1367_CR95","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.nlm.2016.01.001","volume":"128","author":"TJ Jarome","year":"2016","unstructured":"Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ. CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval. Neurobiol Learn Mem 2016, 128: 103\u2013109.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR96","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fncir.2017.00053","volume":"11","author":"B Huang","year":"2017","unstructured":"Huang B, Zhu H, Zhou Y, Liu X, Ma L. Unconditioned- and conditioned- stimuli induce differential memory reconsolidation and \u03b2-AR-dependent CREB activation. Front Neural Circuits 2017, 11: 53.","journal-title":"Front Neural Circuits"},{"key":"1367_CR97","doi-asserted-by":"publisher","first-page":"6580","DOI":"10.3390\/ijms21186580","volume":"21","author":"L Bellfy","year":"2020","unstructured":"Bellfy L, Kwapis JL. Molecular mechanisms of reconsolidation-dependent memory updating. Int J Mol Sci 2020, 21: 6580.","journal-title":"Int J Mol Sci"},{"key":"1367_CR98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151381","volume":"11","author":"C Forcato","year":"2016","unstructured":"Forcato C, Bavassi L, De Pino G, Fern\u00e1ndez RS, Villarreal MF, Pedreira ME. Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process. PLoS One 2016, 11: e0151381.","journal-title":"PLoS One"},{"key":"1367_CR99","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.janxdis.2015.10.004","volume":"36","author":"M Mahabir","year":"2015","unstructured":"Mahabir M, Tucholka A, Shin LM, Etienne P, Brunet A. Emotional face processing in post-traumatic stress disorder after reconsolidation impairment using propranolol: A pilot fMRI study. J Anxiety Disord 2015, 36: 127\u2013133.","journal-title":"J Anxiety Disord"},{"key":"1367_CR100","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S0896-6273(02)01064-4","volume":"36","author":"KM Myers","year":"2002","unstructured":"Myers KM, Davis M. Behavioral and neural analysis of extinction. Neuron 2002, 36: 567\u2013584.","journal-title":"Neuron"},{"key":"1367_CR101","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1101\/lm.76904","volume":"11","author":"ME Pedreira","year":"2004","unstructured":"Pedreira ME, P\u00e9rez-Cuesta LM, Maldonado H. Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction. Learn Mem 2004, 11: 579\u2013585.","journal-title":"Learn Mem"},{"key":"1367_CR102","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbr.2015.03.031","volume":"287","author":"S Gonz\u00e1lez-Salinas","year":"2015","unstructured":"Gonz\u00e1lez-Salinas S, Medina AC, Mar\u00edn-Vignando V, Ruiz-L\u00f3pez CX, Quirarte GL, Prado-Alcal\u00e1 RA. Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training. Behav Brain Res 2015, 287: 8\u201314.","journal-title":"Behav Brain Res"},{"key":"1367_CR103","doi-asserted-by":"crossref","unstructured":"Santini E, Ge H, Ren K, Pe\u00f1a de Ortiz S, Quirk GJ. Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci 2004, 24: 5704\u20135710.","DOI":"10.1523\/JNEUROSCI.0786-04.2004"},{"key":"1367_CR104","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51207","volume":"9","author":"B Popik","year":"2020","unstructured":"Popik B, Amorim FE, Amaral OB, De Oliveira Alvares L. Shifting from fear to safety through deconditioning-update. Elife 2020, 9: e51207.","journal-title":"Elife"},{"key":"1367_CR105","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuron.2015.09.028","volume":"88","author":"JE Dunsmoor","year":"2015","unstructured":"Dunsmoor JE, Niv Y, Daw N, Phelps EA. Rethinking extinction. Neuron 2015, 88: 47\u201363.","journal-title":"Neuron"},{"key":"1367_CR106","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1152\/physrev.00016.2020","volume":"101","author":"ME Bouton","year":"2021","unstructured":"Bouton ME, Maren S, McNally GP. Behavioral and neurobiological mechanisms of Pavlovian and instrumental extinction learning. Physiol Rev 2021, 101: 611\u2013681.","journal-title":"Physiol Rev"},{"key":"1367_CR107","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s41398-022-02174-8","volume":"12","author":"C Szeska","year":"2022","unstructured":"Szeska C, P\u00fcnjer H, Riemann S, Meinzer M, Hamm AO. Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses. Transl Psychiatry 2022, 12: 394.","journal-title":"Transl Psychiatry"},{"key":"1367_CR108","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1007\/s00429-022-02545-3","volume":"227","author":"CC Shih","year":"2022","unstructured":"Shih CC, Chang YH, Chiou RJ, Chang CH. Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit. Brain Struct Funct 2022, 227: 2529\u20132541.","journal-title":"Brain Struct Funct"},{"key":"1367_CR109","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3390\/ijms22020810","volume":"22","author":"D Laricchiuta","year":"2021","unstructured":"Laricchiuta D, Sciamanna G, Gimenez J, Termine A, Fabrizio C, Caioli S, et al. Optogenetic stimulation of prelimbic pyramidal neurons maintains fear memories and modulates amygdala pyramidal neuron transcriptome. Int J Mol Sci 2021, 22: 810.","journal-title":"Int J Mol Sci"},{"key":"1367_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112913","volume":"396","author":"O Bukalo","year":"2021","unstructured":"Bukalo O, Nonaka M, Weinholtz CA, Mendez A, Taylor WW, Holmes A. Effects of optogenetic photoexcitation of infralimbic cortex inputs to the basolateral amygdala on conditioned fear and extinction. Behav Brain Res 2021, 396: 112913.","journal-title":"Behav Brain Res"},{"key":"1367_CR111","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41593-018-0137-x","volume":"21","author":"R Marek","year":"2018","unstructured":"Marek R, Xu L, Sullivan RKP, Sah P. Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction. Nat Neurosci 2018, 21: 654\u2013658.","journal-title":"Nat Neurosci"},{"key":"1367_CR112","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41593-021-00856-y","volume":"24","author":"BA Silva","year":"2021","unstructured":"Silva BA, Astori S, Burns AM, Heiser H, van den Heuvel L, Santoni G, et al. A thalamo-amygdalar circuit underlying the extinction of remote fear memories. Nat Neurosci 2021, 24: 964\u2013974.","journal-title":"Nat Neurosci"},{"key":"1367_CR113","doi-asserted-by":"publisher","first-page":"10396","DOI":"10.1523\/JNEUROSCI.5539-12.2013","volume":"33","author":"AM Jasnow","year":"2013","unstructured":"Jasnow AM, Ehrlich DE, Choi DC, Dabrowska J, Bowers ME, McCullough KM, et al. Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition. J Neurosci 2013, 33: 10396\u201310404.","journal-title":"J Neurosci"},{"key":"1367_CR114","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nn.4523","volume":"20","author":"O Klavir","year":"2017","unstructured":"Klavir O, Prigge M, Sarel A, Paz R, Yizhar O. Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex. Nat Neurosci 2017, 20: 836\u2013844.","journal-title":"Nat Neurosci"},{"key":"1367_CR115","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1038\/s41380-022-01684-7","volume":"27","author":"X Gu","year":"2022","unstructured":"Gu X, Wu YJ, Zhang Z, Zhu JJ, Wu XR, Wang Q, et al. Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory. Mol Psychiatry 2022, 27: 4077\u20134091.","journal-title":"Mol Psychiatry"},{"key":"1367_CR116","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/sj.npp.1301555","volume":"33","author":"GJ Quirk","year":"2008","unstructured":"Quirk GJ, Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 2008, 33: 56\u201372.","journal-title":"Neuropsychopharmacology"},{"key":"1367_CR117","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41593-018-0073-9","volume":"21","author":"R Marek","year":"2018","unstructured":"Marek R, Jin J, Goode TD, Giustino TF, Wang Q, Acca GM, et al. Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nat Neurosci 2018, 21: 384\u2013392.","journal-title":"Nat Neurosci"},{"key":"1367_CR118","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1093\/cercor\/bhaa320","volume":"31","author":"C Qin","year":"2021","unstructured":"Qin C, Bian XL, Wu HY, Xian JY, Cai CY, Lin YH, et al. Dorsal hippocampus to infralimbic cortex circuit is essential for the recall of extinction memory. Cereb Cortex 2021, 31: 1707\u20131718.","journal-title":"Cereb Cortex"},{"key":"1367_CR119","doi-asserted-by":"publisher","first-page":"eadg4881","DOI":"10.1126\/sciadv.adg4881","volume":"9","author":"R Nguyen","year":"2023","unstructured":"Nguyen R, Koukoutselos K, Forro T, Ciocchi S. Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala. Sci Adv 2023, 9: eadg4881.","journal-title":"Sci Adv"},{"key":"1367_CR120","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00213-018-5121-3","volume":"236","author":"EN Cahill","year":"2019","unstructured":"Cahill EN, Milton AL. Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. Psychopharmacology (Berl) 2019, 236: 111\u2013132.","journal-title":"Psychopharmacology (Berl)"},{"key":"1367_CR121","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/sj.mp.4001939","volume":"12","author":"KM Myers","year":"2007","unstructured":"Myers KM, Davis M. Mechanisms of fear extinction. Mol Psychiatry 2007, 12: 120\u2013150.","journal-title":"Mol Psychiatry"},{"key":"1367_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118261","volume":"238","author":"Z Wen","year":"2021","unstructured":"Wen Z, Chen ZS, Milad MR. Fear extinction learning modulates large-scale brain connectivity. Neuroimage 2021, 238: 118261.","journal-title":"Neuroimage"},{"key":"1367_CR123","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0896-6273(00)80475-4","volume":"20","author":"KS LaBar","year":"1998","unstructured":"LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron 1998, 20: 937\u2013945.","journal-title":"Neuron"},{"key":"1367_CR124","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1523\/JNEUROSCI.2713-18.2019","volume":"39","author":"JE Dunsmoor","year":"2019","unstructured":"Dunsmoor JE, Kroes MCW, Li J, Daw ND, Simpson HB, Phelps EA. Role of human ventromedial prefrontal cortex in learning and recall of enhanced extinction. J Neurosci 2019, 39: 3264\u20133276.","journal-title":"J Neurosci"},{"key":"1367_CR125","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s12311-015-0670-z","volume":"14","author":"DI Chang","year":"2015","unstructured":"Chang DI, Lissek S, Ernst TM, Th\u00fcrling M, Uengoer M, Tegenthoff M, et al. Cerebellar contribution to context processing in extinction learning and recall. Cerebellum 2015, 14: 670\u2013676.","journal-title":"Cerebellum"},{"key":"1367_CR126","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3758\/CABN.4.3.317","volume":"4","author":"DC Knight","year":"2004","unstructured":"Knight DC, Smith CN, Cheng DT, Stein EA, Helmstetter FJ. Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning. Cogn Affect Behav Neurosci 2004, 4: 317\u2013325.","journal-title":"Cogn Affect Behav Neurosci"},{"key":"1367_CR127","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.neuron.2008.06.029","volume":"59","author":"MR Delgado","year":"2008","unstructured":"Delgado MR, Nearing KI, Ledoux JE, Phelps EA. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 2008, 59: 829\u2013838.","journal-title":"Neuron"},{"key":"1367_CR128","doi-asserted-by":"publisher","first-page":"16701","DOI":"10.1038\/srep16701","volume":"5","author":"P Feng","year":"2015","unstructured":"Feng P, Zheng Y, Feng T. Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI. Sci Rep 2015, 5: 16701.","journal-title":"Sci Rep"},{"key":"1367_CR129","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1017\/S0033291719001387","volume":"50","author":"B Suarez-Jimenez","year":"2020","unstructured":"Suarez-Jimenez B, Albajes-Eizagirre A, Lazarov A, Zhu X, Harrison BJ, Radua J, et al. Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: A meta-analysis of functional magnetic resonance imaging studies. Psychol Med 2020, 50: 1442\u20131451.","journal-title":"Psychol Med"},{"key":"1367_CR130","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.biopsych.2014.02.014","volume":"77","author":"JC Motzkin","year":"2015","unstructured":"Motzkin JC, Philippi CL, Wolf RC, Baskaya MK, Koenigs M. Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans. Biol Psychiatry 2015, 77: 276\u2013284.","journal-title":"Biol Psychiatry"},{"key":"1367_CR131","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1093\/scan\/nsw031","volume":"11","author":"P Feng","year":"2016","unstructured":"Feng P, Zheng Y, Feng T. Resting-state functional connectivity between amygdala and the ventromedial prefrontal cortex following fear reminder predicts fear extinction. Soc Cogn Affect Neurosci 2016, 11: 991\u20131001.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1367_CR132","doi-asserted-by":"publisher","first-page":"16678","DOI":"10.1073\/pnas.2004258117","volume":"117","author":"L Faul","year":"2020","unstructured":"Faul L, Stjepanovi\u0107 D, Stivers JM, Stewart GW, Graner JL, Morey RA, et al. Proximal threats promote enhanced acquisition and persistence of reactive fear-learning circuits. Proc Natl Acad Sci USA 2020, 117: 16678\u201316689.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1367_CR133","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2006.10.011","volume":"62","author":"MR Milad","year":"2007","unstructured":"Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry 2007, 62: 446\u2013454.","journal-title":"Biol Psychiatry"},{"key":"1367_CR134","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.biopsych.2007.04.032","volume":"62","author":"MR Milad","year":"2007","unstructured":"Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL. A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry 2007, 62: 1191\u20131194.","journal-title":"Biol Psychiatry"},{"key":"1367_CR135","first-page":"403","volume":"5","author":"SF Miedl","year":"2020","unstructured":"Miedl SF, Rattel JA, Franke LK, Blechert J, Kronbichler M, Spoormaker VI, et al. Neural processing during fear extinction predicts intrusive memories. Biol Psychiatry Cogn Neurosci Neuroimaging 2020, 5: 403\u2013411.","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"1367_CR136","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1755-5949.2010.00152.x","volume":"17","author":"A Rougemont-B\u00fccking","year":"2011","unstructured":"Rougemont-B\u00fccking A, Linnman C, Zeffiro TA, Zeidan MA, Lebron-Milad K, Rodriguez-Romaguera J, et al. Altered processing of contextual information during fear extinction in PTSD: An fMRI study. CNS Neurosci Ther 2011, 17: 227\u2013236.","journal-title":"CNS Neurosci Ther"},{"key":"1367_CR137","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cortex.2019.09.003","volume":"121","author":"J Li","year":"2019","unstructured":"Li J, Chen W, Caoyang J, Hu Y, Yang Y, Xu L, et al. Role of prediction error in destabilizing fear memories in retrieval extinction and its neural mechanisms. Cortex 2019, 121: 292\u2013307.","journal-title":"Cortex"},{"key":"1367_CR138","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.nlm.2014.01.016","volume":"113","author":"AM Apergis-Schoute","year":"2014","unstructured":"Apergis-Schoute AM, Schiller D, LeDoux JE, Phelps EA. Extinction resistant changes in the human auditory association cortex following threat learning. Neurobiol Learn Mem 2014, 113: 109\u2013114.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR139","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.neuroimage.2008.08.021","volume":"43","author":"EC Finger","year":"2008","unstructured":"Finger EC, Mitchell DGV, Jones M, Blair RR. Dissociable roles of medial orbitofrontal cortex in human operant extinction learning. Neuroimage 2008, 43: 748\u2013755.","journal-title":"Neuroimage"},{"key":"1367_CR140","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0896-6273(02)01001-2","volume":"36","author":"J Debiec","year":"2002","unstructured":"Debiec J, LeDoux JE, Nader K. Cellular and systems reconsolidation in the hippocampus. Neuron 2002, 36: 527\u2013538.","journal-title":"Neuron"},{"key":"1367_CR141","doi-asserted-by":"publisher","first-page":"12251","DOI":"10.1073\/pnas.211433298","volume":"98","author":"MR Vianna","year":"2001","unstructured":"Vianna MR, Szapiro G, McGaugh JL, Medina JH, Izquierdo I. Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus. Proc Natl Acad Sci USA 2001, 98: 12251\u201312254.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1367_CR142","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1126\/science.1058165","volume":"291","author":"DE Berman","year":"2001","unstructured":"Berman DE, Dudai Y. Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex. Science 2001, 291: 2417\u20132419.","journal-title":"Science"},{"key":"1367_CR143","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1101\/lm.413507","volume":"14","author":"LM P\u00e9rez-Cuesta","year":"2007","unstructured":"P\u00e9rez-Cuesta LM, Hepp Y, Pedreira ME, Maldonado H. Memory is not extinguished along with CS presentation but within a few seconds after CS-offset. Learn Mem 2007, 14: 101\u2013108.","journal-title":"Learn Mem"},{"key":"1367_CR144","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1460-9568.2006.04907.x","volume":"24","author":"S Duvarci","year":"2006","unstructured":"Duvarci S, Mamou CB, Nader K. Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala. Eur J Neurosci 2006, 24: 249\u2013260.","journal-title":"Eur J Neurosci"},{"key":"1367_CR145","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1101\/lm.1544609","volume":"16","author":"LM P\u00e9rez-Cuesta","year":"2009","unstructured":"P\u00e9rez-Cuesta LM, Maldonado H. Memory reconsolidation and extinction in the crab: Mutual exclusion or coexistence? Learn Mem 2009, 16: 714\u2013721.","journal-title":"Learn Mem"},{"key":"1367_CR146","doi-asserted-by":"publisher","first-page":"9269","DOI":"10.1523\/JNEUROSCI.2971-04.2004","volume":"24","author":"S Duvarci","year":"2004","unstructured":"Duvarci S, Nader K. Characterization of fear memory reconsolidation. J Neurosci 2004, 24: 9269\u20139275.","journal-title":"J Neurosci"},{"key":"1367_CR147","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1523\/JNEUROSCI.5491-03.2004","volume":"24","author":"A Suzuki","year":"2004","unstructured":"Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci 2004, 24: 4787\u20134795.","journal-title":"J Neurosci"},{"key":"1367_CR148","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1523\/JNEUROSCI.4001-13.2014","volume":"34","author":"E Merlo","year":"2014","unstructured":"Merlo E, Milton AL, Gooz\u00e9e ZY, Theobald DE, Everitt BJ. Reconsolidation and extinction are dissociable and mutually exclusive processes: Behavioral and molecular evidence. J Neurosci 2014, 34: 2422\u20132431.","journal-title":"J Neurosci"},{"key":"1367_CR149","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fnmol.2018.00361","volume":"11","author":"JH Medina","year":"2018","unstructured":"Medina JH, Viola H. ERK1\/2: A key cellular component for the formation, retrieval, reconsolidation and persistence of memory. Front Mol Neurosci 2018, 11: 361.","journal-title":"Front Mol Neurosci"},{"key":"1367_CR150","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/nature07166","volume":"454","author":"C Herry","year":"2008","unstructured":"Herry C, Ciocchi S, Senn V, Demmou L, M\u00fcller C, L\u00fcthi A. Switching on and off fear by distinct neuronal circuits. Nature 2008, 454: 600\u2013606.","journal-title":"Nature"},{"key":"1367_CR151","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.10234","volume-title":"Die Mneme als erhaltendes Prinzip im Wechsel des organischen Geschehens","author":"RW Semon","year":"1920","unstructured":"Semon RW (1920) Die Mneme als erhaltendes Prinzip im Wechsel des organischen Geschehens. Engelmann, Leipzig."},{"key":"1367_CR152","doi-asserted-by":"publisher","first-page":"eaaw4325","DOI":"10.1126\/science.aaw4325","volume":"367","author":"SA Josselyn","year":"2020","unstructured":"Josselyn SA, Tonegawa S. Memory engrams: Recalling the past and imagining the future. Science 2020, 367: eaaw4325.","journal-title":"Science"},{"key":"1367_CR153","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41583-018-0031-2","volume":"19","author":"S Tonegawa","year":"2018","unstructured":"Tonegawa S, Morrissey MD, Kitamura T. The role of engram cells in the systems consolidation of memory. Nat Rev Neurosci 2018, 19: 485\u2013498.","journal-title":"Nat Rev Neurosci"},{"key":"1367_CR154","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1126\/science.aaa5542","volume":"348","author":"TJ Ryan","year":"2015","unstructured":"Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S. Engram cells retain memory under retrograde Amnesia. Science 2015, 348: 1007\u20131013.","journal-title":"Science"},{"key":"1367_CR155","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/s41593-021-00825-5","volume":"24","author":"RL Ressler","year":"2021","unstructured":"Ressler RL, Goode TD, Kim S, Ramanathan KR, Maren S. Covert capture and attenuation of a hippocampus-dependent fear memory. Nat Neurosci 2021, 24: 677\u2013684.","journal-title":"Nat Neurosci"},{"key":"1367_CR156","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/hipo.23601","volume":"34","author":"JG Luft","year":"2024","unstructured":"Luft JG, Popik B, Gon\u00e7alves DA, Cruz FC, de Oliveira Alvares L. Distinct engrams control fear and extinction memory. Hippocampus 2024, 34: 230\u2013240.","journal-title":"Hippocampus"},{"key":"1367_CR157","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.aas9875","volume":"360","author":"O Khalaf","year":"2018","unstructured":"Khalaf O, Resch S, Dixsaut L, Gorden V, Glauser L, Gr\u00e4ff J. Reactivation of recall-induced neurons contributes to remote fear memory attenuation. Science 2018, 360: 1239\u20131242.","journal-title":"Science"},{"key":"1367_CR158","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1038\/s41467-018-06970-z","volume":"9","author":"KR Ramanathan","year":"2018","unstructured":"Ramanathan KR, Jin J, Giustino TF, Payne MR, Maren S. Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction. Nat Commun 2018, 9: 4527.","journal-title":"Nat Commun"},{"key":"1367_CR159","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41593-019-0361-z","volume":"22","author":"AF Lacagnina","year":"2019","unstructured":"Lacagnina AF, Brockway ET, Crovetti CR, Shue F, McCarty MJ, Sattler KP, et al. Distinct hippocampal engrams control extinction and relapse of fear memory. Nat Neurosci 2019, 22: 753\u2013761.","journal-title":"Nat Neurosci"},{"key":"1367_CR160","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.neuron.2019.12.025","volume":"105","author":"X Zhang","year":"2020","unstructured":"Zhang X, Kim J, Tonegawa S. Amygdala reward neurons form and store fear extinction memory. Neuron 2020, 105: 1077-1093.e7.","journal-title":"Neuron"},{"key":"1367_CR161","doi-asserted-by":"publisher","first-page":"eadf0284","DOI":"10.1126\/sciadv.adf0284","volume":"9","author":"SW Teng","year":"2023","unstructured":"Teng SW, Wang XR, Du BW, Chen XL, Fu GZ, Liu YF, et al. Altered fear engram encoding underlying conditioned versus unconditioned stimulus-initiated memory updating. Sci Adv 2023, 9: eadf0284.","journal-title":"Sci Adv"},{"key":"1367_CR162","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature13725","volume":"513","author":"RL Redondo","year":"2014","unstructured":"Redondo RL, Kim J, Arons AL, Ramirez S, Liu X, Tonegawa S. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature 2014, 513: 426\u2013430.","journal-title":"Nature"},{"key":"1367_CR163","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.nlm.2016.07.007","volume":"135","author":"DJ Morrison","year":"2016","unstructured":"Morrison DJ, Rashid AJ, Yiu AP, Yan C, Frankland PW, Josselyn SA. Parvalbumin interneurons constrain the size of the lateral amygdala engram. Neurobiol Learn Mem 2016, 135: 91\u201399.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR164","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.neuron.2016.01.024","volume":"89","author":"T Stefanelli","year":"2016","unstructured":"Stefanelli T, Bertollini C, L\u00fcscher C, Muller D, Mendez P. Hippocampal somatostatin interneurons control the size of neuronal memory ensembles. Neuron 2016, 89: 1074\u20131085.","journal-title":"Neuron"},{"key":"1367_CR165","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1126\/science.aaf0594","volume":"353","author":"AJ Rashid","year":"2016","unstructured":"Rashid AJ, Yan C, Mercaldo V, Hsiang HL, Park S, Cole CJ, et al. Competition between engrams influences fear memory formation and recall. Science 2016, 353: 383\u2013387.","journal-title":"Science"},{"key":"1367_CR166","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1126\/science.aat3810","volume":"360","author":"K Abdou","year":"2018","unstructured":"Abdou K, Shehata M, Choko K, Nishizono H, Matsuo M, Muramatsu SI, et al. Synapse-specific representation of the identity of overlapping memory engrams. Science 2018, 360: 1227\u20131231.","journal-title":"Science"},{"key":"1367_CR167","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1016\/j.cub.2016.08.022","volume":"26","author":"J Bj\u00f6rkstrand","year":"2016","unstructured":"Bj\u00f6rkstrand J, Agren T, \u00c5hs F, Frick A, Larsson EM, Hjorth O, et al. Disrupting reconsolidation attenuates long-term fear memory in the human amygdala and facilitates approach behavior. Curr Biol 2016, 26: 2690\u20132695.","journal-title":"Curr Biol"},{"key":"1367_CR168","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2021.103831","volume":"139","author":"W Chen","year":"2021","unstructured":"Chen W, Li J, Zhang X, Dong Y, Shi P, Luo P, et al. Retrieval-extinction as a reconsolidation-based treatment for emotional disorders: Evidence from an extinction retention test shortly after intervention. Behav Res Ther 2021, 139: 103831.","journal-title":"Behav Res Ther"},{"key":"1367_CR169","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1111\/psyp.12687","volume":"53","author":"J Fricchione","year":"2016","unstructured":"Fricchione J, Greenberg MS, Spring J, Wood N, Mueller-Pfeiffer C, Milad MR, et al. Delayed extinction fails to reduce skin conductance reactivity to fear-conditioned stimuli. Psychophysiology 2016, 53: 1343\u20131351.","journal-title":"Psychophysiology"},{"key":"1367_CR170","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brat.2018.06.010","volume":"108","author":"M Alexandra Kredlow","year":"2018","unstructured":"Alexandra Kredlow M, Orr SP, Otto MW. Exploring the boundaries of post-retrieval extinction in healthy and anxious individuals. Behav Res Ther 2018, 108: 45\u201357.","journal-title":"Behav Res Ther"},{"key":"1367_CR171","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s40814-023-01396-x","volume":"9","author":"J Sturt","year":"2023","unstructured":"Sturt J, Rogers R, Armour C, Cameron D, De Rijk L, Fiorentino F, et al. Reconsolidation of traumatic memories protocol compared to trauma-focussed cognitive behaviour therapy for post-traumatic stress disorder in UK military veterans: A randomised controlled feasibility trial. Pilot Feasibility Stud 2023, 9: 175.","journal-title":"Pilot Feasibility Stud"},{"key":"1367_CR172","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/10503307.2017.1408973","volume":"29","author":"R Gray","year":"2019","unstructured":"Gray R, Budden-Potts D, Bourke F. Reconsolidation of traumatic memories for PTSD: A randomized controlled trial of 74 male veterans. Psychother Res 2019, 29: 621\u2013639.","journal-title":"Psychother Res"},{"key":"1367_CR173","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3138\/jmvfh.4120","volume":"3","author":"DS Tylee","year":"2017","unstructured":"Tylee DS, Gray R, Glatt SJ, Bourke F. Evaluation of the reconsolidation of traumatic memories protocol for the treatment of PTSD: A randomized, wait-list-controlled trial. J Mil Veteran Fam Health 2017, 3: 21\u201333.","journal-title":"J Mil Veteran Fam Health"},{"key":"1367_CR174","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.598924","volume":"14","author":"W Chen","year":"2021","unstructured":"Chen W, Li J, Xu L, Zhao S, Fan M, Zheng X. Destabilizing different strengths of fear memories requires different degrees of prediction error during retrieval. Front Behav Neurosci 2021, 14: 598924.","journal-title":"Front Behav Neurosci"},{"key":"1367_CR175","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1126\/science.1231357","volume":"339","author":"D Sevenster","year":"2013","unstructured":"Sevenster D, Beckers T, Kindt M. Prediction error governs pharmacologically induced Amnesia for learned fear. Science 2013, 339: 830\u2013833.","journal-title":"Science"},{"key":"1367_CR176","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2019.103461","volume":"122","author":"Y Yang","year":"2019","unstructured":"Yang Y, Jie J, Li J, Chen W, Zheng X. A novel method to trigger the reconsolidation of fear memory. Behav Res Ther 2019, 122: 103461.","journal-title":"Behav Res Ther"},{"key":"1367_CR177","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnbeh.2017.00002","volume":"11","author":"A Auchter","year":"2017","unstructured":"Auchter A, Cormack LK, Niv Y, Gonzalez-Lima F, Monfils MH. Reconsolidation-extinction interactions in fear memory attenuation: The role of inter-trial interval variability. Front Behav Neurosci 2017, 11: 2.","journal-title":"Front Behav Neurosci"},{"key":"1367_CR178","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.brat.2017.02.004","volume":"92","author":"A Golkar","year":"2017","unstructured":"Golkar A, Tjaden C, Kindt M. Vicarious extinction learning during reconsolidation neutralizes fear memory. Behav Res Ther 2017, 92: 87\u201393.","journal-title":"Behav Res Ther"},{"key":"1367_CR179","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.biopsych.2014.03.027","volume":"76","author":"J Liu","year":"2014","unstructured":"Liu J, Zhao L, Xue Y, Shi J, Suo L, Luo Y, et al. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory. Biol Psychiatry 2014, 76: 895\u2013901.","journal-title":"Biol Psychiatry"},{"key":"1367_CR180","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1101\/lm.033589.113","volume":"21","author":"ECK Steinfurth","year":"2014","unstructured":"Steinfurth ECK, Kanen JW, Raio CM, Clem RL, Huganir RL, Phelps EA. Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans. Learn Mem 2014, 21: 338\u2013341.","journal-title":"Learn Mem"},{"key":"1367_CR181","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2020.103730","volume":"135","author":"CL Lancaster","year":"2020","unstructured":"Lancaster CL, Monfils MH, Telch MJ. Augmenting exposure therapy with pre-extinction fear memory reactivation and deepened extinction: A randomized controlled trial. Behav Res Ther 2020, 135: 103730.","journal-title":"Behav Res Ther"},{"key":"1367_CR182","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1037\/tra0000986","volume":"13","author":"RM Gray","year":"2021","unstructured":"Gray RM, Budden-Potts D, Schwall RJ, Bourke FF. An open-label, randomized controlled trial of the reconsolidation of traumatic memories protocol (RTM) in military women. Psychol Trauma 2021, 13: 641\u2013651.","journal-title":"Psychol Trauma"},{"key":"1367_CR183","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004206","volume":"20","author":"AB Witteveen","year":"2023","unstructured":"Witteveen AB, Young SY, Cuijpers P, Ayuso-Mateos JL, Barbui C, Bertolini F, et al. COVID-19 and common mental health symptoms in the early phase of the pandemic: An umbrella review of the evidence. PLoS Med 2023, 20: e1004206.","journal-title":"PLoS Med"},{"key":"1367_CR184","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41598-022-06119-5","volume":"12","author":"LE Stemerding","year":"2022","unstructured":"Stemerding LE, Stibbe D, van Ast VA, Kindt M. Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication. Sci Rep 2022, 12: 2285.","journal-title":"Sci Rep"},{"key":"1367_CR185","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1016\/j.cub.2023.07.042","volume":"33","author":"R Refaeli","year":"2023","unstructured":"Refaeli R, Kreisel T, Groysman M, Adamsky A, Goshen I. Engram stability and maturation during systems consolidation. Curr Biol 2023, 33: 3942-3950.e3.","journal-title":"Curr Biol"},{"key":"1367_CR186","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/s41467-020-14498-4","volume":"11","author":"K Gulmez Karaca","year":"2020","unstructured":"Gulmez Karaca K, Kupke J, Brito DVC, Zeuch B, Thome C, Weichenhan D, et al. Neuronal ensemble-specific DNA methylation strengthens engram stability. Nat Commun 2020, 11: 639.","journal-title":"Nat Commun"},{"key":"1367_CR187","doi-asserted-by":"publisher","first-page":"220","DOI":"10.4103\/0019-5545.117131","volume":"55","author":"VN Vahia","year":"2013","unstructured":"Vahia VN. Diagnostic and statistical manual of mental disorders 5: A quick glance. Indian J Psychiatry 2013, 55: 220\u2013223.","journal-title":"Indian J Psychiatry"},{"key":"1367_CR188","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/acps.13200","volume":"142","author":"JI Bisson","year":"2020","unstructured":"Bisson JI, van Deursen R, Hannigan B, Kitchiner N, Barawi K, Jones K, et al. Randomized controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder. Acta Psychiatr Scand 2020, 142: 141\u2013151.","journal-title":"Acta Psychiatr Scand"},{"key":"1367_CR189","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neunet.2020.04.013","volume":"127","author":"RMM Santiago","year":"2020","unstructured":"Santiago RMM, Tort ABL. On the boundary conditions of avoidance memory reconsolidation: An attractor network perspective. Neural Netw 2020, 127: 96\u2013109.","journal-title":"Neural Netw"},{"key":"1367_CR190","doi-asserted-by":"publisher","first-page":"20230108","DOI":"10.1098\/rsif.2023.0108","volume":"20","author":"MB Bonsall","year":"2023","unstructured":"Bonsall MB, Holmes EA. Temporal dynamics of trauma memory persistence. J R Soc Interface 2023, 20: 20230108.","journal-title":"J R Soc Interface"},{"key":"1367_CR191","doi-asserted-by":"publisher","first-page":"eado3927","DOI":"10.1126\/science.ado3927","volume":"385","author":"S Hao","year":"2024","unstructured":"Hao S, Zhu X, Huang Z, Yang Q, Liu H, Wu Y, et al. Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex. Science 2024, 385: eado3927.","journal-title":"Science"},{"key":"1367_CR192","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s12264-024-01184-4","volume":"40","author":"X He","year":"2024","unstructured":"He X, Calhoun VD, Du Y. SMART (splitting-merging assisted reliable) independent component analysis for extracting accurate brain functional networks. Neurosci Bull 2024, 40: 905\u2013920.","journal-title":"Neurosci Bull"},{"key":"1367_CR193","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nn.2520","volume":"13","author":"J Debiec","year":"2010","unstructured":"Debiec J, D\u00edaz-Mataix L, Bush DEA, Doy\u00e8re V, Ledoux JE. The amygdala encodes specific sensory features of an aversive reinforcer. Nat Neurosci 2010, 13: 536\u2013537.","journal-title":"Nat Neurosci"},{"key":"1367_CR194","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/ejn.13503","volume":"45","author":"NV Bal","year":"2017","unstructured":"Bal NV, Rysakova MP, Vinarskaya AK, Ivanova V, Zuzina AB, Balaban PM. Cued memory reconsolidation in rats requires nitric oxide. Eur J Neurosci 2017, 45: 643\u2013647.","journal-title":"Eur J Neurosci"},{"key":"1367_CR195","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1101\/lm.027227.112","volume":"19","author":"E\u00d6 Einarsson","year":"2012","unstructured":"Einarsson E\u00d6, Nader K. Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory. Learn Mem 2012, 19: 449\u2013452.","journal-title":"Learn Mem"},{"key":"1367_CR196","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1460-9568.2004.03824.x","volume":"21","author":"S Duvarci","year":"2005","unstructured":"Duvarci S, Nader K, LeDoux JE. Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning. Eur J Neurosci 2005, 21: 283\u2013289.","journal-title":"Eur J Neurosci"},{"key":"1367_CR197","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroscience.2004.08.018","volume":"129","author":"J Debiec","year":"2004","unstructured":"Debiec J, Ledoux JE. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience 2004, 129: 267\u2013272.","journal-title":"Neuroscience"},{"key":"1367_CR198","doi-asserted-by":"publisher","first-page":"10051","DOI":"10.1523\/JNEUROSCI.2466-06.2006","volume":"26","author":"JLC Lee","year":"2006","unstructured":"Lee JLC, Milton AL, Everitt BJ. Reconsolidation and extinction of conditioned fear: Inhibition and potentiation. J Neurosci 2006, 26: 10051\u201310056.","journal-title":"J Neurosci"},{"key":"1367_CR199","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3109\/10253890.2010.548171","volume":"14","author":"S Nikzad","year":"2011","unstructured":"Nikzad S, Vafaei AA, Rashidy-Pour A, Haghighi S. Systemic and intrahippocampal administrations of the glucocorticoid receptor antagonist RU38486 impairs fear memory reconsolidation in rats. Stress 2011, 14: 459\u2013464.","journal-title":"Stress"},{"key":"1367_CR200","doi-asserted-by":"publisher","first-page":"8218","DOI":"10.1073\/pnas.1305235110","volume":"110","author":"I Hong","year":"2013","unstructured":"Hong I, Kim J, Kim J, Lee S, Ko HG, Nader K, et al. AMPA receptor exchange underlies transient memory destabilization on retrieval. Proc Natl Acad Sci U S A 2013, 110: 8218\u20138223.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1367_CR201","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.nlm.2006.01.003","volume":"86","author":"V Cestari","year":"2006","unstructured":"Cestari V, Costanzi M, Castellano C, Rossi-Arnaud C. A role for ERK2 in reconsolidation of fear memories in mice. Neurobiol Learn Mem 2006, 86: 133\u2013143.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR202","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nn1628","volume":"9","author":"NC Tronson","year":"2006","unstructured":"Tronson NC, Wiseman SL, Olausson P, Taylor JR. Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A. Nat Neurosci 2006, 9: 167\u2013169.","journal-title":"Nat Neurosci"},{"key":"1367_CR203","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.nlm.2013.08.014","volume":"112","author":"PE Mac Callum","year":"2014","unstructured":"Mac Callum PE, Hebert M, Adamec RE, Blundell J. Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory. Neurobiol Learn Mem 2014, 112: 176\u2013185.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR204","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043973","volume":"7","author":"J Si","year":"2012","unstructured":"Si J, Yang J, Xue L, Yang C, Luo Y, Shi H, et al. Activation of NF-\u03baB in basolateral amygdala is required for memory reconsolidation in auditory fear conditioning. PLoS One 2012, 7: e43973.","journal-title":"PLoS One"},{"key":"1367_CR205","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1007\/s00213-014-3462-0","volume":"231","author":"P Wu","year":"2014","unstructured":"Wu P, Ding ZB, Meng SQ, Shen HW, Sun SC, Luo YX, et al. Differential role of Rac in the basolateral amygdala and Cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats. Psychopharmacology (Berl) 2014, 231: 2909\u20132919.","journal-title":"Psychopharmacology (Berl)"},{"key":"1367_CR206","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1101\/lm.1027208","volume":"15","author":"S Duvarci","year":"2008","unstructured":"Duvarci S, Nader K, LeDoux JE. De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala. Learn Mem 2008, 15: 747\u2013755.","journal-title":"Learn Mem"},{"key":"1367_CR207","doi-asserted-by":"publisher","first-page":"7073","DOI":"10.1523\/JNEUROSCI.1120-11.2011","volume":"31","author":"SA Maddox","year":"2011","unstructured":"Maddox SA, Schafe GE. The activity-regulated cytoskeletal-associated protein (Arc\/Arg3.1) is required for reconsolidation of a Pavlovian fear memory. J Neurosci 2011, 31: 7073\u20137082.","journal-title":"J Neurosci"},{"key":"1367_CR208","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1101\/lm.183406","volume":"13","author":"PW Frankland","year":"2006","unstructured":"Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ. Stability of recent and remote contextual fear memory. Learn Mem 2006, 13: 451\u2013457.","journal-title":"Learn Mem"},{"key":"1367_CR209","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.nlm.2016.12.017","volume":"142","author":"SD Schmidt","year":"2017","unstructured":"Schmidt SD, Furini CG, Zinn CG, Cavalcante LE, Ferreira FF, Behling JK, et al. Modulation of the consolidation and reconsolidation of fear memory by three different serotonin receptors in hippocampus. Neurobiol Learn Mem 2017, 142: 48\u201354.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR210","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1111\/j.1460-9568.2006.04723.x","volume":"23","author":"RG Parsons","year":"2006","unstructured":"Parsons RG, Gafford GM, Baruch DE, Riedner BA, Helmstetter FJ. Long-term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala. Eur J Neurosci 2006, 23: 1853\u20131859.","journal-title":"Eur J Neurosci"},{"key":"1367_CR211","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00702-017-1704-0","volume":"124","author":"A Saitoh","year":"2017","unstructured":"Saitoh A, Akagi K, Oka JI, Yamada M. Post-reexposure administration of D-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats. J Neural Transm (Vienna) 2017, 124: 583\u2013587.","journal-title":"J Neural Transm (Vienna)"},{"key":"1367_CR212","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.neuroscience.2011.07.034","volume":"193","author":"Y Charlier","year":"2011","unstructured":"Charlier Y, Tirelli E. Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice. Neuroscience 2011, 193: 132\u2013142.","journal-title":"Neuroscience"},{"key":"1367_CR213","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/hipo.22083","volume":"23","author":"JLC Lee","year":"2013","unstructured":"Lee JLC, Hynds RE. Divergent cellular pathways of hippocampal memory consolidation and reconsolidation. Hippocampus 2013, 23: 233\u2013244.","journal-title":"Hippocampus"},{"key":"1367_CR214","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1038\/npp.2009.86","volume":"34","author":"D Yamada","year":"2009","unstructured":"Yamada D, Zushida K, Wada K, Sekiguchi M. Pharmacological discrimination of extinction and reconsolidation of contextual fear memory by a potentiator of AMPA receptors. Neuropsychopharmacology 2009, 34: 2574\u20132584.","journal-title":"Neuropsychopharmacology"},{"key":"1367_CR215","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2020.107343","volume":"177","author":"F Troyner","year":"2021","unstructured":"Troyner F, Bertoglio LJ. Nucleus reuniens of the thalamus controls fear memory reconsolidation. Neurobiol Learn Mem 2021, 177: 107343.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR216","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1101\/lm.326906","volume":"13","author":"C Bucherelli","year":"2006","unstructured":"Bucherelli C, Baldi E, Mariottini C, Passani MB, Blandina P. Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation. Learn Mem 2006, 13: 426\u2013430.","journal-title":"Learn Mem"},{"key":"1367_CR217","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.neuroscience.2008.05.005","volume":"154","author":"Alvares L de Oliveira","year":"2008","unstructured":"de Oliveira Alvares L, Pasqualini Genro B, Diehl F, Molina VA, Quillfeldt JA. Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. Neuroscience 2008, 154: 1648\u20131655.","journal-title":"Neuroscience"},{"key":"1367_CR218","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.neuroscience.2005.12.064","volume":"139","author":"SG Bustos","year":"2006","unstructured":"Bustos SG, Maldonado H, Molina VA. Midazolam disrupts fear memory reconsolidation. Neuroscience 2006, 139: 831\u2013842.","journal-title":"Neuroscience"},{"key":"1367_CR219","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bbr.2017.11.037","volume":"347","author":"A Murkar","year":"2018","unstructured":"Murkar A, Kent P, Cayer C, James J, Merali Z. Gastrin-releasing peptide attenuates fear memory reconsolidation. Behav Brain Res 2018, 347: 255\u2013262.","journal-title":"Behav Brain Res"},{"key":"1367_CR220","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbr.2012.12.063","volume":"243","author":"C Brabant","year":"2013","unstructured":"Brabant C, Charlier Y, Tirelli E. The histamine H-receptor inverse agonist pitolisant improves fear memory in mice. Behav Brain Res 2013, 243: 199\u2013204.","journal-title":"Behav Brain Res"},{"key":"1367_CR221","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.neuron.2007.07.039","volume":"55","author":"FD Lubin","year":"2007","unstructured":"Lubin FD, David Sweatt J. The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 2007, 55: 942\u2013957.","journal-title":"Neuron"},{"key":"1367_CR222","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/hipo.20879","volume":"22","author":"P Barnes","year":"2012","unstructured":"Barnes P, Kirtley A, Thomas KL. Quantitatively and qualitatively different cellular processes are engaged in CA1 during the consolidation and reconsolidation of contextual fear memory. Hippocampus 2012, 22: 149\u2013171.","journal-title":"Hippocampus"},{"key":"1367_CR223","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/nn.2907","volume":"14","author":"P Rao-Ruiz","year":"2011","unstructured":"Rao-Ruiz P, Rotaru DC, van der Loo RJ, Mansvelder HD, Stiedl O, Smit AB, et al. Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear. Nat Neurosci 2011, 14: 1302\u20131308.","journal-title":"Nat Neurosci"},{"key":"1367_CR224","doi-asserted-by":"publisher","first-page":"4076","DOI":"10.1038\/s41598-020-60046-x","volume":"10","author":"TR da Silva","year":"2020","unstructured":"da Silva TR, Raymundi AM, Bertoglio LJ, Andreatini R, Stern CA. Role of prelimbic cortex PKC and PKM\u03b6 in fear memory reconsolidation and persistence following reactivation. Sci Rep 2020, 10: 4076.","journal-title":"Sci Rep"},{"key":"1367_CR225","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.nlm.2007.12.004","volume":"90","author":"J Blundell","year":"2008","unstructured":"Blundell J, Kouser M, Powell CM. Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation. Neurobiol Learn Mem 2008, 90: 28\u201335.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR226","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.nlm.2008.07.009","volume":"90","author":"E Baldi","year":"2008","unstructured":"Baldi E, Mariottini C, Bucherelli C. Differential roles of the basolateral amygdala and nucleus basalis magnocellularis during post-reactivation contextual fear conditioning reconsolidation in rats. Neurobiol Learn Mem 2008, 90: 604\u2013609.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR227","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.nlm.2014.02.004","volume":"110","author":"E Baldi","year":"2014","unstructured":"Baldi E, Bucherelli C. Entorhinal cortex contribution to contextual fear conditioning extinction and reconsolidation in rats. Neurobiol Learn Mem 2014, 110: 64\u201371.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR228","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.nlm.2018.04.002","volume":"151","author":"B Popik","year":"2018","unstructured":"Popik B, Crestani AP, Silva MO, Quillfeldt JA, de Oliveira Alvares L. Calpain modulates fear memory consolidation, retrieval and reconsolidation in the hippocampus. Neurobiol Learn Mem 2018, 151: 53\u201358.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR229","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13041-017-0341-8","volume":"10","author":"T Nagayoshi","year":"2017","unstructured":"Nagayoshi T, Isoda K, Mamiya N, Kida S. Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory. Mol Brain 2017, 10: 61.","journal-title":"Mol Brain"},{"key":"1367_CR230","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.euroneuro.2017.06.007","volume":"27","author":"N Levin","year":"2017","unstructured":"Levin N, Kritman M, Maroun M, Akirav I. Differential roles of the infralimbic and prelimbic areas of the prefrontal cortex in reconsolidation of a traumatic memory. Eur Neuropsychopharmacol 2017, 27: 900\u2013912.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1367_CR231","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/s41598-018-37089-2","volume":"9","author":"L Bavassi","year":"2019","unstructured":"Bavassi L, Forcato C, Fern\u00e1ndez RS, De Pino G, Pedreira ME, Villarreal MF. Retrieval of retrained and reconsolidated memories are associated with a distinct neural network. Sci Rep 2019, 9: 784.","journal-title":"Sci Rep"},{"key":"1367_CR232","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2019.107047","volume":"164","author":"F Shen","year":"2019","unstructured":"Shen F, Chen X, Li J, Cao W, Ku Y, Wu J, et al. Mnemonic vulnerability induced by post-activation time-dependent new-learning. Neurobiol Learn Mem 2019, 164: 107047.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR233","doi-asserted-by":"publisher","first-page":"6601","DOI":"10.1038\/s41467-021-26906-4","volume":"12","author":"ME Speer","year":"2021","unstructured":"Speer ME, Ibrahim S, Schiller D, Delgado MR. Finding positive meaning in memories of negative events adaptively updates memory. Nat Commun 2021, 12: 6601.","journal-title":"Nat Commun"},{"key":"1367_CR234","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109274","volume":"221","author":"HM Kawade","year":"2022","unstructured":"Kawade HM, Awathale SN, Subhedar NK, Kokare DM. Neuropeptide S facilitates extinction of fear via modulation of mesolimbic dopaminergic circuitry. Neuropharmacology 2022, 221: 109274.","journal-title":"Neuropharmacology"},{"key":"1367_CR235","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1038\/s41467-018-04784-7","volume":"9","author":"R Luo","year":"2018","unstructured":"Luo R, Uematsu A, Weitemier A, Aquili L, Koivumaa J, McHugh TJ, et al. A dopaminergic switch for fear to safety transitions. Nat Commun 2018, 9: 2483.","journal-title":"Nat Commun"},{"key":"1367_CR236","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuron.2019.05.029","volume":"103","author":"A Sengupta","year":"2019","unstructured":"Sengupta A, Holmes A. A discrete dorsal raphe to basal amygdala 5-HT circuit calibrates aversive memory. Neuron 2019, 103: 489-505.e7.","journal-title":"Neuron"},{"key":"1367_CR237","doi-asserted-by":"publisher","first-page":"5207","DOI":"10.1038\/s41467-020-18953-0","volume":"11","author":"JL Frontera","year":"2020","unstructured":"Frontera JL, Baba Aissa H, Sala RW, Mailhes-Hamon C, Georgescu IA, L\u00e9na C, et al. Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey. Nat Commun 2020, 11: 5207.","journal-title":"Nat Commun"},{"key":"1367_CR238","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41586-019-0931-y","volume":"566","author":"J Baek","year":"2019","unstructured":"Baek J, Lee S, Cho T, Kim SW, Kim M, Yoon Y, et al. Neural circuits underlying a psychotherapeutic regimen for fear disorders. Nature 2019, 566: 339\u2013343.","journal-title":"Nature"},{"key":"1367_CR239","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1038\/s41467-019-12496-9","volume":"10","author":"JH Lee","year":"2019","unstructured":"Lee JH, Latchoumane CV, Park J, Kim J, Jeong J, Lee KH, et al. The rostroventral part of the thalamic reticular nucleus modulates fear extinction. Nat Commun 2019, 10: 4637.","journal-title":"Nat Commun"},{"key":"1367_CR240","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s12264-020-00603-6","volume":"37","author":"Y Tao","year":"2021","unstructured":"Tao Y, Cai CY, Xian JY, Kou XL, Lin YH, Qin C, et al. Projections from infralimbic cortex to paraventricular thalamus mediate fear extinction retrieval. Neurosci Bull 2021, 37: 229\u2013241.","journal-title":"Neurosci Bull"},{"key":"1367_CR241","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.biopsych.2009.01.009","volume":"65","author":"J Rodriguez-Romaguera","year":"2009","unstructured":"Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction. Biol Psychiatry 2009, 65: 887\u2013892.","journal-title":"Biol Psychiatry"},{"key":"1367_CR242","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1523\/JNEUROSCI.1676-21.2021","volume":"42","author":"Y Ren","year":"2022","unstructured":"Ren Y, Liu Y, Zheng S, Luo M. KCTD8 and KCTD12 facilitate axonal expression of GABAB receptors in habenula cholinergic neurons. J Neurosci 2022, 42: 1648\u20131665.","journal-title":"J Neurosci"},{"key":"1367_CR243","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/ncomms1515","volume":"2","author":"CR Flavell","year":"2011","unstructured":"Flavell CR, Barber DJ, Lee JLC. Behavioural memory reconsolidation of food and fear memories. Nat Commun 2011, 2: 504.","journal-title":"Nat Commun"},{"key":"1367_CR244","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.nlm.2010.05.007","volume":"94","author":"E Baldi","year":"2010","unstructured":"Baldi E, Bucherelli C. Substantia nigra, nucleus basalis magnocellularis and basolateral amygdala roles in extinction of contextual fear conditioning in the rat. Neurobiol Learn Mem 2010, 94: 199\u2013205.","journal-title":"Neurobiol Learn Mem"},{"key":"1367_CR245","doi-asserted-by":"crossref","unstructured":"Schmidt do Prado-Lima PA, Perrenoud MF, Kristensen CH, Cammarota M, Izquierdo I. Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats. J Psychiatry Neurosci 2011, 36: 250\u2013255.","DOI":"10.1503\/jpn.100115"},{"key":"1367_CR246","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112958","volume":"398","author":"HA Marusak","year":"2021","unstructured":"Marusak HA, Hehr A, Bhogal A, Peters C, Iadipaolo A, Rabinak CA. Alterations in fear extinction neural circuitry and fear-related behavior linked to trauma exposure in children. Behav Brain Res 2021, 398: 112958.","journal-title":"Behav Brain Res"},{"key":"1367_CR247","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2015.07.026","volume":"604","author":"A Utz","year":"2015","unstructured":"Utz A, Th\u00fcrling M, Ernst TM, Hermann A, Stark R, Wolf OT, et al. Cerebellar vermis contributes to the extinction of conditioned fear. Neurosci Lett 2015, 604: 173\u2013177.","journal-title":"Neurosci Lett"},{"key":"1367_CR248","doi-asserted-by":"publisher","first-page":"115330","DOI":"10.1016\/j.psychres.2023.115330","volume":"326","author":"KH Walter","year":"2023","unstructured":"Walter KH, Michael Hunt W, Otis NP, Kline AC, Miggantz EL, Thomsen CJ, et al. Comparison of behavioral activation-enhanced cognitive processing therapy and cognitive processing therapy among U.S. service members: A randomized clinical trial. Psychiatry Res 2023, 326: 115330.","journal-title":"Psychiatry Res"},{"key":"1367_CR249","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2023.106221","volume":"141","author":"R Steil","year":"2023","unstructured":"Steil R, Weiss J, Renneberg B, Gutermann J, Rosner R. Effect of therapeutic competence, adherence, and alliance on treatment outcome in youth with PTSD treated with developmentally adapted cognitive processing therapy. Child Abuse Negl 2023, 141: 106221.","journal-title":"Child Abuse Negl"},{"key":"1367_CR250","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/jts.22915","volume":"36","author":"SA Stoycos","year":"2023","unstructured":"Stoycos SA, Berzenski SR, Gayle Beck J, Unger W, Cappellano JM, Spofford CM, et al. Predictors of treatment completion in group psychotherapy for male veterans with posttraumatic stress disorder. J Trauma Stress 2023, 36: 346\u2013358.","journal-title":"J Trauma Stress"},{"key":"1367_CR251","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/15299732.2016.1205704","volume":"18","author":"CL Franklin","year":"2017","unstructured":"Franklin CL, Cuccurullo LA, Walton JL, Arseneau JR, Petersen NJ. Face to face but not in the same place: A pilot study of prolonged exposure therapy. J Trauma Dissociation 2017, 18: 116\u2013130.","journal-title":"J Trauma Dissociation"},{"key":"1367_CR252","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.janxdis.2019.02.003","volume":"64","author":"SR Thorp","year":"2019","unstructured":"Thorp SR, Glassman LH, Wells SY, Walter KH, Gebhardt H, Twamley E, et al. A randomized controlled trial of prolonged exposure therapy versus relaxation training for older veterans with military-related PTSD. J Anxiety Disord 2019, 64: 45\u201354.","journal-title":"J Anxiety Disord"},{"key":"1367_CR253","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1001\/jama.2017.21242","volume":"319","author":"EB Foa","year":"2018","unstructured":"Foa EB, McLean CP, Zang Y, Rosenfield D, Yadin E, Yarvis JS, et al. Effect of prolonged exposure therapy delivered over 2 weeks vs 8 weeks vs present-centered therapy on PTSD symptom severity in military personnel: A randomized clinical trial. JAMA 2018, 319: 354\u2013364.","journal-title":"JAMA"},{"key":"1367_CR254","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1080\/16506073.2021.2001689","volume":"51","author":"S Young-McCaughan","year":"2022","unstructured":"Young-McCaughan S, Peterson AL, Mintz J, Hale WJ, Dondanville KA, Borah EV, et al. Testing the role of aerobic exercise in the treatment of posttraumatic stress disorder (PTSD) symptoms in U.S. active duty military personnel: A pilot study. Cogn Behav Ther 2022, 51: 309\u2013325.","journal-title":"Cogn Behav Ther"},{"key":"1367_CR255","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.janxdis.2018.06.001","volume":"61","author":"GM Reger","year":"2019","unstructured":"Reger GM, Smolenski D, Norr A, Katz A, Buck B, Rothbaum BO. Does virtual reality increase emotional engagement during exposure for PTSD? Subjective distress during prolonged and virtual reality exposure therapy. J Anxiety Disord 2019, 61: 75\u201381.","journal-title":"J Anxiety Disord"},{"key":"1367_CR256","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1089\/cyber.2016.0554","volume":"20","author":"RN McLay","year":"2017","unstructured":"McLay RN, Baird A, Webb-Murphy J, Deal W, Tran L, Anson H, et al. A randomized, head-to-head study of virtual reality exposure therapy for posttraumatic stress disorder. Cyberpsychol Behav Soc Netw 2017, 20: 218\u2013224.","journal-title":"Cyberpsychol Behav Soc Netw"},{"key":"1367_CR257","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.janxdis.2017.05.001","volume":"50","author":"DC Beidel","year":"2017","unstructured":"Beidel DC, Christopher Frueh B, Neer SM, Lejuez CW. The efficacy of trauma management therapy: A controlled pilot investigation of a three-week intensive outpatient program for combat-related PTSD. J Anxiety Disord 2017, 50: 23\u201332.","journal-title":"J Anxiety Disord"},{"key":"1367_CR258","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1037\/tra0000978","volume":"13","author":"CP McLean","year":"2021","unstructured":"McLean CP, Foa EB, Dondanville KA, Haddock CK, Miller ML, Rauch SAM, et al. The effects of web-prolonged exposure among military personnel and veterans with posttraumatic stress disorder. Psychol Trauma 2021, 13: 621\u2013631.","journal-title":"Psychol Trauma"},{"key":"1367_CR259","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s12888-016-0969-4","volume":"16","author":"C Steuwe","year":"2016","unstructured":"Steuwe C, Rullk\u00f6tter N, Ertl V, Berg M, Neuner F, Beblo T, et al. Effectiveness and feasibility of Narrative Exposure Therapy (NET) in patients with borderline personality disorder and posttraumatic stress disorder - a pilot study. BMC Psychiatry 2016, 16: 254.","journal-title":"BMC Psychiatry"},{"key":"1367_CR260","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000440726","volume":"85","author":"W Butollo","year":"2016","unstructured":"Butollo W, Karl R, K\u00f6nig J, Rosner R. A randomized controlled clinical trial of dialogical exposure therapy versus cognitive processing therapy for adult outpatients suffering from PTSD after type I trauma in adulthood. Psychother Psychosom 2016, 85: 16\u201326.","journal-title":"Psychother Psychosom"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01367-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01367-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01367-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:06:00Z","timestamp":1749643560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01367-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":260,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1367"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01367-7","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"7 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}