{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:08:06Z","timestamp":1791986886090,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12264-025-01404-5","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:26:45Z","timestamp":1745555205000},"page":"1403-1417","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5213-8145","authenticated-orcid":false,"given":"Wen-Guang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang-Feng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-7227","authenticated-orcid":false,"given":"Li-Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"1404_CR1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/SHK.0000000000000925","volume":"49","author":"S Denk","year":"2018","unstructured":"Denk S, Weckbach S, Eisele P, Braun CK, Wiegner R, Ohmann JJ. Role of hemorrhagic shock in experimental polytrauma. Shock 2018, 49: 154\u2013163.","journal-title":"Shock"},{"key":"1404_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.blre.2014.12.006","volume":"29","author":"TH Pohlman","year":"2015","unstructured":"Pohlman TH, Walsh M, Aversa J, Hutchison EM, Olsen KP, Lawrence Reed R. Damage control resuscitation. Blood Rev 2015, 29: 251\u2013262.","journal-title":"Blood Rev"},{"key":"1404_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/00024382-199903000-00007","volume":"11","author":"M Silomon","year":"1999","unstructured":"Silomon M, Pizanis A, Rose S. Oxyradical-mediated hepatocellular Ca2+ alterations during hemorrhagic shock and resuscitation. Shock 1999, 11: 193\u2013198.","journal-title":"Shock"},{"key":"1404_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/SHK.0000000000001708","volume":"56","author":"S L\u2019Ecuyer","year":"2021","unstructured":"L\u2019Ecuyer S, Gilbert K, Brochu B, Beyrouthy J, Liu C, Bouchard C, et al. Targeting uric acid prevents brain injury and anxiety in a rat model of hemorrhagic shock. Shock 2021, 56: 298\u2013307.","journal-title":"Shock"},{"key":"1404_CR5","doi-asserted-by":"publisher","first-page":"9771743","DOI":"10.1155\/2022\/9771743","volume":"2022","author":"J Shu","year":"2022","unstructured":"Shu J, Huang X, Liao Q, Wang J, Zhou Y, Chen Y, et al. Sevoflurane improves hemorrhagic shock and resuscitation-induced cognitive impairments and mitochondrial dysfunctions through SIRT1-mediated autophagy. Oxid Med Cell Longev 2022, 2022: 9771743.","journal-title":"Oxid Med Cell Longev"},{"key":"1404_CR6","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.neulet.2018.08.035","volume":"685","author":"X Hu","year":"2018","unstructured":"Hu X, Zhang M, Duan X, Zhang Q, Huang C, Huang L, et al. Sevoflurane postconditioning improves the spatial learning and memory impairments induced by hemorrhagic shock and resuscitation through suppressing IRE1\u03b1-caspase-12-mediated endoplasmic reticulum stress pathway. Neurosci Lett 2018, 685: 160\u2013166.","journal-title":"Neurosci Lett"},{"key":"1404_CR7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1177\/1533317518791401","volume":"33","author":"S Jongsiriyanyong","year":"2018","unstructured":"Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: A review article. Am J Alzheimers Dis Other Demen 2018, 33: 500\u2013507.","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"1404_CR8","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1007\/s12264-023-01074-1","volume":"39","author":"M Zhang","year":"2023","unstructured":"Zhang M, Zhang Y, Xu Q, Crawford J, Qian C, Wang GH, et al. Neuronal histone methyltransferase EZH2 regulates neuronal morphogenesis, synaptic plasticity, and cognitive behavior in mice. Neurosci Bull 2023, 39: 1512\u20131532.","journal-title":"Neurosci Bull"},{"key":"1404_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cger.2017.02.005","volume":"33","author":"AM Sanford","year":"2017","unstructured":"Sanford AM. Mild cognitive impairment. Clin Geriatr Med 2017, 33: 325\u2013337.","journal-title":"Clin Geriatr Med"},{"key":"1404_CR10","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1007\/s12035-023-03804-y","volume":"61","author":"RX Song","year":"2024","unstructured":"Song RX, Miao HT, Jia SY, Li WG, Liu JZ, Zhang W, et al. Hemorrhagic shock and resuscitation causes excessive dopaminergic signaling in the mPFC and cognitive dysfunction. Mol Neurobiol 2024, 61: 3899\u20133910.","journal-title":"Mol Neurobiol"},{"key":"1404_CR11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57155","volume":"9","author":"Y Li","year":"2020","unstructured":"Li Y, Li L, Wu J, Zhu Z, Feng X, Qin L, et al. Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors. Elife 2020, 9: e57155.","journal-title":"Elife"},{"key":"1404_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2018.05.002","volume":"174","author":"A Adamsky","year":"2018","unstructured":"Adamsky A, Kol A, Kreisel T, Doron A, Ozeri-Engelhard N, Melcer T, et al. Astrocytic activation generates de novo neuronal potentiation and memory enhancement. Cell 2018, 174: 59-71.e14.","journal-title":"Cell"},{"key":"1404_CR13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nn.4201","volume":"19","author":"N Bazargani","year":"2016","unstructured":"Bazargani N, Attwell D. Astrocyte calcium signaling: The third wave. Nat Neurosci 2016, 19: 182\u2013189.","journal-title":"Nat Neurosci"},{"key":"1404_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40659-024-00503-3","volume":"57","author":"M Puebla","year":"2024","unstructured":"Puebla M, Mu\u00f1oz MF, Lillo MA, Contreras JE, Figueroa XF. Control of astrocytic Ca2+ signaling by nitric oxide-dependent S-nitrosylation of Ca2+ homeostasis modulator 1 channels. Biol Res 2024, 57: 19.","journal-title":"Biol Res"},{"key":"1404_CR15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41380-022-01922-y","volume":"28","author":"D Wang","year":"2023","unstructured":"Wang D, Pan X, Zhou Y, Wu Z, Ren K, Liu H, et al. Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety. Mol Psychiatry 2023, 28: 1090\u20131100.","journal-title":"Mol Psychiatry"},{"key":"1404_CR16","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1016\/j.cell.2023.08.010","volume":"186","author":"NS de Le\u00f3n Reyes","year":"2023","unstructured":"de Le\u00f3n Reyes NS, Sierra D\u00edaz P, Nogueira R, Ruiz-Pino A, Nomura Y, de Solis CA, et al. Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. Cell 2023, 186: 4152-4171.e31.","journal-title":"Cell"},{"key":"1404_CR17","first-page":"14","volume":"2023","author":"M Wang","year":"1880","unstructured":"Wang M, Li P, Li Z, da Silva BS, Zheng W, Xiang Z, et al. Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula. Nat Commun 1880, 2023: 14.","journal-title":"Nat Commun"},{"key":"1404_CR18","first-page":"657","volume":"74","author":"X Lyu","year":"2022","unstructured":"Lyu X, Yang XY, Zhou ZK. Neural oscillation and its application in mechanistic study of neuropsychiatric disorders. Sheng Li Xue Bao 2022, 74: 657\u2013668.","journal-title":"Sheng Li Xue Bao"},{"key":"1404_CR19","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1093\/brain\/awad206","volume":"146","author":"DL Paulo","year":"2023","unstructured":"Paulo DL, Qian H, Subramanian D, Johnson GW, Zhao Z, Hett K, et al. Corticostriatal beta oscillation changes associated with cognitive function in Parkinson\u2019s disease. Brain 2023, 146: 3662\u20133675.","journal-title":"Brain"},{"key":"1404_CR20","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1523\/JNEUROSCI.3543-15.2016","volume":"36","author":"J Wagner","year":"2016","unstructured":"Wagner J, Makeig S, Gola M, Neuper C, M\u00fcller-Putz G. Distinct \u03b2 band oscillatory networks subserving motor and cognitive control during gait adaptation. J Neurosci 2016, 36: 2212\u20132226.","journal-title":"J Neurosci"},{"key":"1404_CR21","doi-asserted-by":"publisher","first-page":"1187272","DOI":"10.3389\/fnsys.2023.1187272","volume":"17","author":"JT Miles","year":"2023","unstructured":"Miles JT, Kidder KS, Mizumori SJY. Hippocampal beta rhythms as a bridge between sensory learning and memory-guided decision-making. Front Syst Neurosci 2023, 17: 1187272.","journal-title":"Front Syst Neurosci"},{"key":"1404_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.nicl.2013.07.003","volume":"3","author":"B G\u00fcntekin","year":"2013","unstructured":"G\u00fcntekin B, Emek-Sava\u015f DD, Kurt P, Yener GG, Ba\u015far E. Beta oscillatory responses in healthy subjects and subjects with mild cognitive impairment. Neuroimage Clin 2013, 3: 39\u201346.","journal-title":"Neuroimage Clin"},{"key":"1404_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11302-023-09946-x","volume":"20","author":"YF Zhao","year":"2024","unstructured":"Zhao YF, Illes P. Adenosine A2A receptor-bearing GABAergic neurons in the lateral septum of the brain: Novel mediators of depressive-like behavior. Purinergic Signal 2024, 20: 209\u2013211.","journal-title":"Purinergic Signal"},{"key":"1404_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149548","volume":"699","author":"S Sun","year":"2024","unstructured":"Sun S, Xu J, Lin L, Jia M, Xue X, Wang Q, et al. Chemotherapeutic drug elemene induces pain and anxiety-like behaviors by activating GABAergic neurons in the lateral septum of mice. Biochem Biophys Res Commun 2024, 699: 149548.","journal-title":"Biochem Biophys Res Commun"},{"key":"1404_CR25","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.freeradbiomed.2019.06.031","volume":"141","author":"LM Zhang","year":"2019","unstructured":"Zhang LM, Zhang DX, Fu L, Li Y, Wang XP, Qi MM, et al. Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation. Free Radic Biol Med 2019, 141: 299\u2013309.","journal-title":"Free Radic Biol Med"},{"key":"1404_CR26","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s12035-022-03085-x","volume":"60","author":"LM Zhang","year":"2023","unstructured":"Zhang LM, Zhang DX, Song RX, Lv JM, Wang LY, Wu ZY, et al. IL-18BP alleviates anxiety-like behavior induced by traumatic stress via inhibition of the IL-18R-NLRP3 signaling pathway in a mouse model of hemorrhagic shock and resuscitation. Mol Neurobiol 2023, 60: 382\u2013394.","journal-title":"Mol Neurobiol"},{"key":"1404_CR27","doi-asserted-by":"publisher","first-page":"12838","DOI":"10.1038\/s41598-017-12811-8","volume":"7","author":"A Takahashi","year":"2017","unstructured":"Takahashi A, Chung JR, Zhang S, Zhang H, Grossman Y, Aleyasin H, et al. Establishment of a repeated social defeat stress model in female mice. Sci Rep 2017, 7: 12838.","journal-title":"Sci Rep"},{"key":"1404_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1501","volume":"10","author":"L Zhang","year":"2020","unstructured":"Zhang L, Huang L, Wang J, Zhang M, Zhang Y, Hu X. Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats. Brain Behav 2020, 10: e01501.","journal-title":"Brain Behav"},{"key":"1404_CR29","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.tins.2015.09.001","volume":"38","author":"A Hyafil","year":"2015","unstructured":"Hyafil A, Giraud AL, Fontolan L, Gutkin B. Neural cross-frequency coupling: Connecting architectures, mechanisms, and functions. Trends Neurosci 2015, 38: 725\u2013740.","journal-title":"Trends Neurosci"},{"key":"1404_CR30","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/hipo.22757","volume":"27","author":"AG Richardson","year":"2017","unstructured":"Richardson AG, Liu X, Weigand PK, Hudgins ED, Stein JM, Das SR, et al. Hippocampal gamma-slow oscillation coupling in macaques during sedation and sleep. Hippocampus 2017, 27: 1125\u20131139.","journal-title":"Hippocampus"},{"key":"1404_CR31","doi-asserted-by":"publisher","first-page":"13139","DOI":"10.1523\/JNEUROSCI.2591-14.2014","volume":"34","author":"DE Bonder","year":"2014","unstructured":"Bonder DE, McCarthy KD. Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo. J Neurosci 2014, 34: 13139\u201313150.","journal-title":"J Neurosci"},{"key":"1404_CR32","doi-asserted-by":"publisher","first-page":"14143","DOI":"10.3390\/ijms232214143","volume":"23","author":"A Bej","year":"2022","unstructured":"Bej A, Ames JB. Retinal cyclic nucleotide-gated channel regulation by calmodulin. Int J Mol Sci 2022, 23: 14143.","journal-title":"Int J Mol Sci"},{"key":"1404_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-019-1413-y","volume":"572","author":"W Tian","year":"2019","unstructured":"Tian W, Hou C, Ren Z, Wang C, Zhao F, Dahlbeck D, et al. A calmodulin-gated calcium channel links pathogen patterns to plant immunity. Nature 2019, 572: 131\u2013135.","journal-title":"Nature"},{"key":"1404_CR34","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/00005373-199809000-00022","volume":"45","author":"SR Heckbert","year":"1998","unstructured":"Heckbert SR, Vedder NB, Hoffman W, Winn RK, Hudson LD, Jurkovich GJ, et al. Outcome after hemorrhagic shock in trauma patients. J Trauma 1998, 45: 545\u2013549.","journal-title":"J Trauma"},{"key":"1404_CR35","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1089\/neu.2008.0512","volume":"26","author":"AM Dennis","year":"2009","unstructured":"Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, et al. Hemorrhagic shock after experimental traumatic brain injury in mice: Effect on neuronal death. J Neurotrauma 2009, 26: 889\u2013899.","journal-title":"J Neurotrauma"},{"key":"1404_CR36","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1089\/neu.2011.2303","volume":"29","author":"JN Hemerka","year":"2012","unstructured":"Hemerka JN, Wu X, Edward Dixon C, Garman RH, Exo JL, Shellington DK, et al. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice. J Neurotrauma 2012, 29: 2192\u20132208.","journal-title":"J Neurotrauma"},{"key":"1404_CR37","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s12264-023-01147-1","volume":"40","author":"X Dong","year":"2024","unstructured":"Dong X, Zhang Z, Shu X, Zhuang Z, Liu P, Liu R, et al. MFG-E8 alleviates cognitive impairments induced by chronic cerebral hypoperfusion by phagocytosing myelin debris and promoting remyelination. Neurosci Bull 2024, 40: 483\u2013499.","journal-title":"Neurosci Bull"},{"key":"1404_CR38","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","volume":"177","author":"AJ Martorell","year":"2019","unstructured":"Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, et al. Multi-sensory gamma stimulation ameliorates Alzheimer\u2019s-associated pathology and improves cognition. Cell 2019, 177: 256-271.e22.","journal-title":"Cell"},{"key":"1404_CR39","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.nicl.2014.03.007","volume":"4","author":"CA Chen","year":"2014","unstructured":"Chen CA, Stanford AD, Mao X, Abi-Dargham A, Shungu DC, Lisanby SH, et al. GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin 2014, 4: 531\u2013539.","journal-title":"Neuroimage Clin"},{"key":"1404_CR40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.neuropsychologia.2015.04.033","volume":"79","author":"AM Cebolla","year":"2015","unstructured":"Cebolla AM, Cheron G. Sensorimotor and cognitive involvement of the beta-gamma oscillation in the frontal N30 component of somatosensory evoked potentials. Neuropsychologia 2015, 79: 215\u2013222.","journal-title":"Neuropsychologia"},{"key":"1404_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108415","volume":"33","author":"P Huang","year":"2020","unstructured":"Huang P, Xiang X, Chen X, Li H. Somatostatin neurons govern Theta oscillations induced by salient visual signals. Cell Rep 2020, 33: 108415.","journal-title":"Cell Rep"},{"key":"1404_CR42","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neuron.2008.11.024","volume":"61","author":"MM Halassa","year":"2009","unstructured":"Halassa MM, Florian C, Fellin T, Munoz JR, Lee SY, Abel T, et al. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 2009, 61: 213\u2013219.","journal-title":"Neuron"},{"key":"1404_CR43","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1017\/S1740925X10000153","volume":"6","author":"C Henneberger","year":"2010","unstructured":"Henneberger C, Rusakov DA. Synaptic plasticity and Ca2+ signalling in astrocytes. Neuron Glia Biol 2010, 6: 141\u2013146.","journal-title":"Neuron Glia Biol"},{"key":"1404_CR44","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1042\/BST20140195","volume":"42","author":"TL Stephen","year":"2014","unstructured":"Stephen TL, Gupta-Agarwal S, Kittler JT. Mitochondrial dynamics in astrocytes. Biochem Soc Trans 2014, 42: 1302\u20131310.","journal-title":"Biochem Soc Trans"},{"key":"1404_CR45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41594-017-0011-7","volume":"25","author":"D Hilger","year":"2018","unstructured":"Hilger D, Masureel M, Kobilka BK. Structure and dynamics of GPCR signaling complexes. Nat Struct Mol Biol 2018, 25: 4\u201312.","journal-title":"Nat Struct Mol Biol"},{"key":"1404_CR46","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1210\/en.2006-1711","volume":"148","author":"K Kisfalvi","year":"2007","unstructured":"Kisfalvi K, Rey O, Young SH, Sinnett-Smith J, Rozengurt E. Insulin potentiates Ca2+ signaling and phosphatidylinositol 4, 5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathway. Endocrinology 2007, 148: 3246\u20133257.","journal-title":"Endocrinology"},{"key":"1404_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000186689","volume":"17","author":"N Mizuno","year":"2009","unstructured":"Mizuno N, Itoh H. Functions and regulatory mechanisms of gq-signaling pathways. Neurosignals 2009, 17: 42\u201354.","journal-title":"Neurosignals"},{"key":"1404_CR48","doi-asserted-by":"crossref","unstructured":"Morishima M, Tahara S, Wang Y, Ono K. Oxytocin downregulates the CaV1.2 L-type Ca2+ channel via gi\/cAMP\/PKA\/CREB signaling pathway in cardiomyocytes. Membranes (Basel) 2021, 11: 234.","DOI":"10.3390\/membranes11040234"},{"key":"1404_CR49","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn3875","volume":"16","author":"ET Kavalali","year":"2015","unstructured":"Kavalali ET. The mechanisms and functions of spontaneous neurotransmitter release. Nat Rev Neurosci 2015, 16: 5\u201316.","journal-title":"Nat Rev Neurosci"},{"key":"1404_CR50","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0165-6147(00)01800-9","volume":"22","author":"SE Jarvis","year":"2001","unstructured":"Jarvis SE, Zamponi GW. Interactions between presynaptic Ca2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex. Trends Pharmacol Sci 2001, 22: 519\u2013525.","journal-title":"Trends Pharmacol Sci"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01404-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01404-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01404-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T14:24:56Z","timestamp":1757168696000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01404-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1404"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01404-5","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"29 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}