{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:46:07Z","timestamp":1768016767861,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12264-025-01493-2","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:15:47Z","timestamp":1758298547000},"page":"175-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38\u03b1"],"prefix":"10.1007","volume":"42","author":[{"given":"Shanshan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueping","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huidong","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"1493_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13123","volume":"21","author":"YJ Li","year":"2020","unstructured":"Li YJ, Xie XN, Lei X, Li YM, Lei X. Global prevalence of obesity, overweight and underweight in children, adolescents and adults with autism spectrum disorder, attention-deficit hyperactivity disorder: A systematic review and meta-analysis. Obes Rev 2020, 21: e13123.","journal-title":"Obes Rev"},{"key":"1493_CR2","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/jcpp.13538","volume":"63","author":"R Ahlberg","year":"2022","unstructured":"Ahlberg R, Garcia-Argibay M, Hirvikoski T, Boman M, Chen Q, Taylor MJ. Shared familial risk factors between autism spectrum disorder and obesity\u2013a register-based familial coaggregation cohort study. J Child Psychol Psychiatry 2022, 63: 890\u2013899.","journal-title":"J Child Psychol Psychiatry"},{"key":"1493_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/chi.2016.0079","volume":"13","author":"A Must","year":"2017","unstructured":"Must A, Eliasziw M, Phillips SM, Curtin C, Kral TVE, Segal M, et al. The effect of age on the prevalence of obesity among US youth with autism spectrum disorder. Child Obes 2017, 13: 25\u201335.","journal-title":"Child Obes"},{"key":"1493_CR4","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1007\/s10803-016-2762-0","volume":"46","author":"SM McCoy","year":"2016","unstructured":"McCoy SM, Jakicic JM, Gibbs BB. Comparison of obesity, physical activity, and sedentary behaviors between adolescents with autism spectrum disorders and without. J Autism Dev Disord 2016, 46: 2317\u20132326.","journal-title":"J Autism Dev Disord"},{"key":"1493_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41586-019-1278-0","volume":"570","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Sharma J, Ke Q, Landman R, Yuan J, Chen H, et al. Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature 2019, 570: 326\u2013331.","journal-title":"Nature"},{"key":"1493_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.neuron.2013.03.016","volume":"78","author":"YH Jiang","year":"2013","unstructured":"Jiang YH, Ehlers MD. Modeling autism by SHANK gene mutations in mice. Neuron 2013, 78: 8\u201327.","journal-title":"Neuron"},{"key":"1493_CR7","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0896-6273(00)80809-0","volume":"23","author":"S Naisbitt","year":"1999","unstructured":"Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, et al. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor\/PSD-95\/GKAP complex and cortactin. Neuron 1999, 23: 569\u2013582.","journal-title":"Neuron"},{"key":"1493_CR8","first-page":"667","volume":"7","author":"E Drapeau","year":"2014","unstructured":"Drapeau E, Dorr NP, Elder GA, Buxbaum JD. Absence of strong strain effects in behavioral analyses of Shank3-deficient mice. Dis Model Mech 2014, 7: 667\u2013681.","journal-title":"Dis Model Mech"},{"key":"1493_CR9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nature12630","volume":"503","author":"K Han","year":"2013","unstructured":"Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 2013, 503: 72\u201377.","journal-title":"Nature"},{"key":"1493_CR10","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature16971","volume":"530","author":"Y Mei","year":"2016","unstructured":"Mei Y, Monteiro P, Zhou Y, Kim JA, Gao X, Fu Z, et al. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature 2016, 530: 481\u2013484.","journal-title":"Nature"},{"key":"1493_CR11","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22092.1","author":"J Han","year":"2020","unstructured":"Han J, Wu J, Silke J. An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. F1000Res 2020, 9: https:\/\/doi.org\/10.12688\/f1000research.22092.1.","journal-title":"F1000Res"},{"key":"1493_CR12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"M Cargnello","year":"2011","unstructured":"Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 2011, 75: 50\u201383.","journal-title":"Microbiol Mol Biol Rev"},{"key":"1493_CR13","doi-asserted-by":"publisher","first-page":"E79","DOI":"10.1073\/pnas.1213000110","volume":"110","author":"Z He","year":"2013","unstructured":"He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, et al. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A 2013, 110: E79\u2013E88.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1493_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004225","volume":"16","author":"S Zhang","year":"2018","unstructured":"Zhang S, Cao H, Li Y, Jing Y, Liu S, Ye C, et al. Metabolic benefits of inhibition of p38\u03b1 in white adipose tissue in obesity. PLoS Biol 2018, 16: e2004225.","journal-title":"PLoS Biol"},{"key":"1493_CR15","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1128\/MCB.24.7.3057-3067.2004","volume":"24","author":"W Cao","year":"2004","unstructured":"Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 2004, 24: 3057\u20133067.","journal-title":"Mol Cell Biol"},{"key":"1493_CR16","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/nm.2449","volume":"17","author":"J Lee","year":"2011","unstructured":"Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, et al. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med 2011, 17: 1251\u20131260.","journal-title":"Nat Med"},{"key":"1493_CR17","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/hep.31390","volume":"72","author":"S Hwang","year":"2020","unstructured":"Hwang S, Wang X, Rodrigues RM, Ma J, He Y, Seo W, et al. Protective and detrimental roles of p38\u03b1 mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease. Hepatology 2020, 72: 873\u2013891.","journal-title":"Hepatology"},{"key":"1493_CR18","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1002\/oby.23552","volume":"30","author":"J Wang","year":"2022","unstructured":"Wang J, Wu S, Zhan H, Bi W, Xu Y, Liang Y, et al. p38\u03b1 in the preoptic area inhibits brown adipose tissue thermogenesis. Obesity (Silver Spring) 2022, 30: 2242\u20132255.","journal-title":"Obesity (Silver Spring)"},{"key":"1493_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13229-024-00595-4","volume":"15","author":"S Wu","year":"2024","unstructured":"Wu S, Wang J, Zhang Z, Jin X, Xu Y, Si Y, et al. Shank3 deficiency elicits autistic-like behaviors by activating p38\u03b1 in hypothalamic AgRP neurons. Mol Autism 2024, 15: 14.","journal-title":"Mol Autism"},{"key":"1493_CR20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nature11705","volume":"491","author":"MG Myers Jr","year":"2012","unstructured":"Myers MG Jr, Olson DP. Central nervous system control of metabolism. Nature 2012, 491: 357\u2013363.","journal-title":"Nature"},{"key":"1493_CR21","doi-asserted-by":"publisher","first-page":"R1111","DOI":"10.1016\/j.cub.2014.10.023","volume":"24","author":"CB Saper","year":"2014","unstructured":"Saper CB, Lowell BB. The hypothalamus. Curr Biol 2014, 24: R1111\u2013R1116.","journal-title":"Curr Biol"},{"key":"1493_CR22","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1242\/dmm.026609","volume":"10","author":"K Timper","year":"2017","unstructured":"Timper K, Br\u00fcning JC. Hypothalamic circuits regulating appetite and energy homeostasis: Pathways to obesity. Dis Model Mech 2017, 10: 679\u2013689.","journal-title":"Dis Model Mech"},{"key":"1493_CR23","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s13238-011-1112-4","volume":"2","author":"Y Xu","year":"2011","unstructured":"Xu Y, Tong Q. Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation. Protein Cell 2011, 2: 800\u2013813.","journal-title":"Protein Cell"},{"key":"1493_CR24","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s13238-021-00834-x","volume":"13","author":"T Liu","year":"2022","unstructured":"Liu T, Xu Y, Yi CX, Tong Q, Cai D. The hypothalamus for whole-body physiology: From metabolism to aging. Protein Cell 2022, 13: 394\u2013421.","journal-title":"Protein Cell"},{"key":"1493_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.neuron.2016.08.032","volume":"92","author":"CJ Burnett","year":"2016","unstructured":"Burnett CJ, Li C, Webber E, Tsaousidou E, Xue SY, Br\u00fcning JC, et al. Hunger-driven motivational state competition. Neuron 2016, 92: 187\u2013201.","journal-title":"Neuron"},{"key":"1493_CR26","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s42255-022-00611-y","volume":"4","author":"IC Alcantara","year":"2022","unstructured":"Alcantara IC, Tapia APM, Aponte Y, Krashes MJ. Acts of appetite: Neural circuits governing the appetitive, consummatory, and terminating phases of feeding. Nat Metab 2022, 4: 836\u2013847.","journal-title":"Nat Metab"},{"key":"1493_CR27","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12264-024-01335-7","volume":"41","author":"J Chen","year":"2025","unstructured":"Chen J, Cai M, Zhan C. Neuronal regulation of feeding and energy metabolism: A focus on the hypothalamus and brainstem. Neurosci Bull 2025, 41: 665\u2013675.","journal-title":"Neurosci Bull"},{"key":"1493_CR28","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nn.2739","volume":"14","author":"Y Aponte","year":"2011","unstructured":"Aponte Y, Atasoy D, Sternson SM. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci 2011, 14: 351\u2013355.","journal-title":"Nat Neurosci"},{"key":"1493_CR29","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1172\/JCI46229","volume":"121","author":"MJ Krashes","year":"2011","unstructured":"Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, et al. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest 2011, 121: 1424\u20131428.","journal-title":"J Clin Invest"},{"key":"1493_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174611","volume":"915","author":"MS Vohra","year":"2022","unstructured":"Vohra MS, Benchoula K, Serpell CJ, Hwa WE. AgRP\/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity. Eur J Pharmacol 2022, 915: 174611.","journal-title":"Eur J Pharmacol"},{"key":"1493_CR31","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s42255-021-00345-3","volume":"3","author":"C Quarta","year":"2021","unstructured":"Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tsch\u00f6p MH, et al. POMC neuronal heterogeneity in energy balance and beyond: An integrated view. Nat Metab 2021, 3: 299\u2013308.","journal-title":"Nat Metab"},{"key":"1493_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s42255-024-00987-z","volume":"6","author":"AJ De Solis","year":"2024","unstructured":"De Solis AJ, Del R\u00edo-Mart\u00edn A, Radermacher J, Chen W, Steuernagel L, Bauder CA, et al. Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nat Metab 2024, 6: 473\u2013493.","journal-title":"Nat Metab"},{"key":"1493_CR33","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nbt811","volume":"21","author":"F Schn\u00fctgen","year":"2003","unstructured":"Schn\u00fctgen F, Doerflinger N, Call\u00e9ja C, Wendling O, Chambon P, Ghyselinck NB. A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol 2003, 21: 562\u2013565.","journal-title":"Nat Biotechnol"},{"key":"1493_CR34","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.neuron.2011.11.027","volume":"73","author":"T Liu","year":"2012","unstructured":"Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, et al. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 2012, 73: 511\u2013522.","journal-title":"Neuron"},{"key":"1493_CR35","doi-asserted-by":"publisher","first-page":"E10245","DOI":"10.1073\/pnas.1809137115","volume":"115","author":"MJ Robson","year":"2018","unstructured":"Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, et al. p38\u03b1 MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A 2018, 115: E10245\u2013E10254.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1493_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.168","volume":"5","author":"NL Baganz","year":"2015","unstructured":"Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H, et al. A requirement of serotonergic p38\u03b1 mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Transl Psychiatry 2015, 5: e671.","journal-title":"Transl Psychiatry"},{"key":"1493_CR37","doi-asserted-by":"publisher","first-page":"47040","DOI":"10.1074\/jbc.M404595200","volume":"279","author":"R Diskin","year":"2004","unstructured":"Diskin R, Askari N, Capone R, Engelberg D, Livnah O. Active mutants of the human p38alpha mitogen-activated protein kinase. J Biol Chem 2004, 279: 47040\u201347049.","journal-title":"J Biol Chem"},{"key":"1493_CR38","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nbt.4201","volume":"36","author":"TC Branon","year":"2018","unstructured":"Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, et al. Efficient proximity labeling in living cells and organisms with TurboID. Nat Biotechnol 2018, 36: 880\u2013887.","journal-title":"Nat Biotechnol"},{"key":"1493_CR39","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1038\/s41467-022-30623-x","volume":"13","author":"S Rayaprolu","year":"2022","unstructured":"Rayaprolu S, Bitarafan S, Santiago JV, Betarbet R, Sunna S, Cheng L, et al. Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain. Nat Commun 2022, 13: 2927.","journal-title":"Nat Commun"},{"key":"1493_CR40","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/humu.23724","volume":"40","author":"WZ Zhou","year":"2019","unstructured":"Zhou WZ, Zhang J, Li Z, Lin X, Li J, Wang S, et al. Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype-phenotype correlations. Hum Mutat 2019, 40: 801\u2013815.","journal-title":"Hum Mutat"},{"key":"1493_CR41","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s12264-024-01237-8","volume":"40","author":"J Liu","year":"2024","unstructured":"Liu J, Ye J, Ji C, Ren W, He Y, Xu F, et al. Mapping the behavioral signatures of Shank3b mice in both sexes. Neurosci Bull 2024, 40: 1299\u20131314.","journal-title":"Neurosci Bull"},{"key":"1493_CR42","doi-asserted-by":"publisher","first-page":"7596","DOI":"10.1038\/s41380-021-01230-x","volume":"26","author":"E Moutin","year":"2021","unstructured":"Moutin E, Sakkaki S, Compan V, Bouquier N, Giona F, Areias J, et al. Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice. Mol Psychiatry 2021, 26: 7596\u20137609.","journal-title":"Mol Psychiatry"},{"key":"1493_CR43","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41398-021-01578-2","volume":"11","author":"S Mencer","year":"2021","unstructured":"Mencer S, Kartawy M, Lendenfeld F, Soluh H, Tripathi MK, Khaliulin I, et al. Proteomics of autism and Alzheimer\u2019s mouse models reveal common alterations in mTOR signaling pathway. Transl Psychiatry 2021, 11: 480.","journal-title":"Transl Psychiatry"},{"key":"1493_CR44","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1083\/jcb.200404108","volume":"167","author":"G Schuetz","year":"2004","unstructured":"Schuetz G, Ros\u00e1rio M, Grimm J, Boeckers TM, Gundelfinger ED, Birchmeier W. The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 2004, 167: 945\u2013952.","journal-title":"J Cell Biol"},{"key":"1493_CR45","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.neuron.2020.01.038","volume":"106","author":"C Tai","year":"2020","unstructured":"Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, et al. Tau reduction prevents key features of autism in mouse models. Neuron 2020, 106: 421-437.e11.","journal-title":"Neuron"},{"key":"1493_CR46","doi-asserted-by":"publisher","first-page":"11459","DOI":"10.1038\/ncomms11459","volume":"7","author":"X Wang","year":"2016","unstructured":"Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, et al. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun 2016, 7: 11459.","journal-title":"Nat Commun"},{"key":"1493_CR47","doi-asserted-by":"publisher","first-page":"15767","DOI":"10.1523\/JNEUROSCI.1175-13.2013","volume":"33","author":"LJ Duffney","year":"2013","unstructured":"Duffney LJ, Wei J, Cheng J, Liu W, Smith KR, Kittler JT, et al. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J Neurosci 2013, 33: 15767\u201315778.","journal-title":"J Neurosci"},{"key":"1493_CR48","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s41586-020-03160-0","volume":"590","author":"PS Minhas","year":"2021","unstructured":"Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature 2021, 590: 122\u2013128.","journal-title":"Nature"},{"key":"1493_CR49","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41586-024-07611-w","volume":"632","author":"SM Theparambil","year":"2024","unstructured":"Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, et al. Adenosine signalling to astrocytes coordinates brain metabolism and function. Nature 2024, 632: 139\u2013146.","journal-title":"Nature"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01493-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01493-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01493-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:02:56Z","timestamp":1767992576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01493-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1493"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01493-2","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}