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Bull."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Nr4a2<\/jats:italic>\n                    (\n                    <jats:italic>Nurr1<\/jats:italic>\n                    ) is well known to be vital for midbrain dopaminergic neurons. Recent single-cell RNA analyses reveal that\n                    <jats:italic>Nr4a2<\/jats:italic>\n                    is expressed in lateral cerebral regions, within neurons named L4\/L5\/L6 IT\n                    <jats:italic>Car3<\/jats:italic>\n                    . These neurons have attracted intense attention for the molecular mechanisms underlying their development and functions. We classified\n                    <jats:italic>Car3<\/jats:italic>\n                    neurons into neocortical (Ncx-\n                    <jats:italic>Car3<\/jats:italic>\n                    ), claustral (CLA-\n                    <jats:italic>Car3<\/jats:italic>\n                    ), and dorsal endopiriform nucleus (dEn-\n                    <jats:italic>Car3<\/jats:italic>\n                    ) subpopulations, focusing on the characterization of Ncx-\n                    <jats:italic>Car3<\/jats:italic>\n                    neurons. These neurons exhibit distinct birthdates and migratory morphologies compared to CLA- and dEn-\n                    <jats:italic>Car3<\/jats:italic>\n                    neurons, but share a common transcriptomic profile when\n                    <jats:italic>Nr4a2<\/jats:italic>\n                    is deleted at the embryonic stage or in adulthood. Notably,\n                    <jats:italic>Nr4a2<\/jats:italic>\n                    misexpression ectopically induces\n                    <jats:italic>Car3<\/jats:italic>\n                    -enriched genes\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Mice lacking\n                    <jats:italic>Nr4a2<\/jats:italic>\n                    in\n                    <jats:italic>Car3<\/jats:italic>\n                    ensembles during the embryonic stage or in adulthood display hyperactivity and reduced anxiety-like behaviors. Therefore, our results demonstrate that Nr4a2 is a key factor in regulating the development and functional maintenance of the forebrain\n                    <jats:italic>Car3<\/jats:italic>\n                    neurons.\n                  <\/jats:p>","DOI":"10.1007\/s12264-025-01496-z","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:10:37Z","timestamp":1757362237000},"page":"649-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5525-8394","authenticated-orcid":false,"given":"Yun-Chao","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Tang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-4561","authenticated-orcid":false,"given":"Ling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-5292","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-4635","authenticated-orcid":false,"given":"Yu-Qiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5206-1911","authenticated-orcid":false,"given":"Ning-Ning","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"1496_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.276.5310.248","volume":"276","author":"RH Zetterstr\u00f6m","year":"1997","unstructured":"Zetterstr\u00f6m RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T. 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