{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:40:54Z","timestamp":1792917654343,"version":"4.5.0"},"reference-count":381,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral nerve injury (PNI) significantly impairs patients\u2019 quality of life, with elderly individuals experiencing particularly severe consequences due to aging-related declines in neuronal injury response and repair capabilities. Processes of the generation and transmission of injury signals, axonal disruption, initiation of regeneration, and the elongation of regenerating axons, as well as the subsequent reinnervation by these axons, are all significantly influenced by aging. These alterations are closely associated with changes in mitochondrial function, neuronal transport systems, a persistent inflammatory milieu, and various microenvironmental non-neuronal cells. Therefore, this review synthesized the pivotal role of aging in the multifaceted regulation of the nervous system following PNI and highlighted promising molecular regulatory mechanisms in the signaling pathways. Furthermore, it identified critical areas for future research, including unresolved questions in age-associated injury responses, potential targets for pharmacological intervention, and emerging therapeutic strategies meriting consideration for research and development.<\/jats:p>","DOI":"10.1007\/s12264-025-01564-4","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:43:20Z","timestamp":1771955000000},"page":"1865-1890","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aging-Related Changes in the Injury Response of the Peripheral Nervous System"],"prefix":"10.1007","volume":"42","author":[{"given":"Yue-Yan","family":"Cen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Xuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0982-2436","authenticated-orcid":false,"given":"Yan-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-1475","authenticated-orcid":false,"given":"Jie-Fei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"1564_CR1","unstructured":"Yi S, Zhang Y, Gu X, Huang L, Zhang K, Qian T, et al. Application of stem cells in peripheral nerve regeneration. Burns Trauma 2020, 8: tkaa002."},{"key":"1564_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41583-020-0269-3","volume":"21","author":"MP Coleman","year":"2020","unstructured":"Coleman MP, H\u00f6ke A. Programmed axon degeneration: From mouse to mechanism to medicine. Nat Rev Neurosci 2020, 21: 183\u2013196.","journal-title":"Nat Rev Neurosci"},{"key":"1564_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.conb.2019.03.006","volume":"57","author":"C Ding","year":"2019","unstructured":"Ding C, Hammarlund M. Mechanisms of injury-induced axon degeneration. Curr Opin Neurobiol 2019, 57: 171\u2013178.","journal-title":"Curr Opin Neurobiol"},{"key":"1564_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41583-018-0001-8","volume":"19","author":"M Mahar","year":"2018","unstructured":"Mahar M, Cavalli V. Intrinsic mechanisms of neuronal axon regeneration. Nat Rev Neurosci 2018, 19: 323\u2013337.","journal-title":"Nat Rev Neurosci"},{"key":"1564_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrn3609","volume":"15","author":"I Rishal","year":"2014","unstructured":"Rishal I, Fainzilber M. Axon-soma communication in neuronal injury. Nat Rev Neurosci 2014, 15: 32\u201342.","journal-title":"Nat Rev Neurosci"},{"key":"1564_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2017.03.034","volume":"94","author":"YL Weng","year":"2017","unstructured":"Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C. An intrinsic epigenetic barrier for functional axon regeneration. Neuron 2017, 94: 337-346.e6.","journal-title":"Neuron"},{"key":"1564_CR7","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1016\/j.jse.2021.04.025","volume":"30","author":"V Entezari","year":"2021","unstructured":"Entezari V, Olson JJ, Vallier HA. Predictors of traumatic nerve injury and nerve recovery following humeral shaft fracture. J Shoulder Elbow Surg 2021, 30: 2711\u20132719.","journal-title":"J Shoulder Elbow Surg"},{"key":"1564_CR8","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00402-020-03348-z","volume":"140","author":"TM Tiefenboeck","year":"2020","unstructured":"Tiefenboeck TM, Zeilinger J, Komjati M, Fialka C, Boesmueller S. Incidence, diagnostics and treatment algorithm of nerve lesions after traumatic shoulder dislocations: A retrospective multicenter study. Arch Orthop Trauma Surg 2020, 140: 1175\u20131180.","journal-title":"Arch Orthop Trauma Surg"},{"key":"1564_CR9","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1038\/s41388-023-02775-7","volume":"42","author":"J Weitz","year":"2023","unstructured":"Weitz J, Garg B, Martsinkovskiy A, Patel S, Tiriac H, Lowy AM. Pancreatic ductal adenocarcinoma induces neural injury that promotes a transcriptomic and functional repair signature by peripheral neuroglia. Oncogene 2023, 42: 2536\u20132546.","journal-title":"Oncogene"},{"key":"1564_CR10","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1016\/j.cmet.2023.10.017","volume":"35","author":"VK Sundaram","year":"2023","unstructured":"Sundaram VK, Sch\u00fctza V, Schr\u00f6ter NH, Backhaus A, Bilsing A, Joneck L, et al. Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. Cell Metab 2023, 35: 2136-2152.e9.","journal-title":"Cell Metab"},{"key":"1564_CR11","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1016\/j.neuron.2023.05.003","volume":"111","author":"SA Eid","year":"2023","unstructured":"Eid SA, Rumora AE, Beirowski B, Bennett DL, Hur J, Savelieff MG, et al. New perspectives in diabetic neuropathy. Neuron 2023, 111: 2623\u20132641.","journal-title":"Neuron"},{"key":"1564_CR12","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1002\/mus.880141113","volume":"14","author":"SE MacKinnon","year":"1991","unstructured":"MacKinnon SE, Dellon AL, O\u2019Brien JP. Changes in nerve fiber numbers distal to a nerve repair in the rat sciatic nerve model. Muscle Nerve 1991, 14: 1116\u20131122.","journal-title":"Muscle Nerve"},{"key":"1564_CR13","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S1474-4422(12)70065-0","volume":"11","author":"BC Callaghan","year":"2012","unstructured":"Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012, 11: 521\u2013534.","journal-title":"Lancet Neurol"},{"key":"1564_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuron.2020.07.026","volume":"108","author":"W Renthal","year":"2020","unstructured":"Renthal W, Tochitsky I, Yang L, Cheng YC, Li E, Kawaguchi R, et al. Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury. Neuron 2020, 108: 128-144.e9.","journal-title":"Neuron"},{"key":"1564_CR15","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/ijms23020918","volume":"23","author":"B Lopes","year":"2022","unstructured":"Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendon\u00e7a C, et al. Peripheral nerve injury treatments and advances: One health perspective. Int J Mol Sci 2022, 23: 918.","journal-title":"Int J Mol Sci"},{"key":"1564_CR16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"DM Wilson 3rd","year":"2023","unstructured":"Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Hallmarks of neurodegenerative diseases. Cell 2023, 186: 693\u2013714.","journal-title":"Cell"},{"key":"1564_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/cne.903080205","volume":"308","author":"K Tanaka","year":"1991","unstructured":"Tanaka K, Webster HD. Myelinated fiber regeneration after crush injury is retarded in sciatic nerves of aging mice. J Comp Neurol 1991, 308: 180\u2013187.","journal-title":"J Comp Neurol"},{"key":"1564_CR18","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/j.1460-9568.1992.tb00126.x","volume":"4","author":"VH Perry","year":"1992","unstructured":"Perry VH, Brown MC, Tsao JW. The effectiveness of the gene which slows the rate of wallerian degeneration in C57BL\/ola mice declines with age. Eur J Neurosci 1992, 4: 1000\u20131002.","journal-title":"Eur J Neurosci"},{"key":"1564_CR19","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1080\/15548627.2020.1713645","volume":"16","author":"SH Ko","year":"2020","unstructured":"Ko SH, Apple EC, Liu Z, Chen L. Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. Autophagy 2020, 16: 2052\u20132068.","journal-title":"Autophagy"},{"key":"1564_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0014-4886(80)90006-0","volume":"70","author":"A Pestronk","year":"1980","unstructured":"Pestronk A, Drachman DB, Griffin JW. Effects of aging on nerve sprouting and regeneration. Exp Neurol 1980, 70: 65\u201382.","journal-title":"Exp Neurol"},{"key":"1564_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/cne.903230207","volume":"323","author":"DW Vaughan","year":"1992","unstructured":"Vaughan DW. Effects of advancing age on peripheral nerve regeneration. J Comp Neurol 1992, 323: 219\u2013237.","journal-title":"J Comp Neurol"},{"key":"1564_CR22","doi-asserted-by":"publisher","first-page":"10052","DOI":"10.1039\/D3TB01927F","volume":"11","author":"X Yang","year":"2023","unstructured":"Yang X, Zhang Y, Liu Y, Wang Y, Zhou N. Fluorescence imaging of peripheral nerve function and structure. J Mater Chem B 2023, 11: 10052\u201310071.","journal-title":"J Mater Chem B"},{"key":"1564_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.05.004","volume":"45","author":"JL Scheib","year":"2016","unstructured":"Scheib JL, H\u00f6ke A. An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. Neurobiol Aging 2016, 45: 1\u20139.","journal-title":"Neurobiol Aging"},{"key":"1564_CR24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell 2023, 186: 243\u2013278.","journal-title":"Cell"},{"key":"1564_CR25","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00401-015-1482-4","volume":"130","author":"P Chen","year":"2015","unstructured":"Chen P, Piao X, Bonaldo P. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathol 2015, 130: 605\u2013618.","journal-title":"Acta Neuropathol"},{"key":"1564_CR26","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1016\/j.celrep.2015.11.032","volume":"13","author":"A Loreto","year":"2015","unstructured":"Loreto A, Di Stefano M, Gering M, Conforti L. Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria. Cell Rep 2015, 13: 2539\u20132552.","journal-title":"Cell Rep"},{"key":"1564_CR27","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1523\/JNEUROSCI.19-12-04718.1999","volume":"19","author":"JW Tsao","year":"1999","unstructured":"Tsao JW, George EB, Griffin JW. Temperature modulation reveals three distinct stages of Wallerian degeneration. J Neurosci 1999, 19: 4718\u20134726.","journal-title":"J Neurosci"},{"key":"1564_CR28","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1083\/jcb.201606020","volume":"216","author":"S Wakatsuki","year":"2017","unstructured":"Wakatsuki S, Tokunaga S, Shibata M, Araki T. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol 2017, 216: 477\u2013493.","journal-title":"J Cell Biol"},{"key":"1564_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev-genet-071819-103917","volume":"55","author":"K Zhang","year":"2021","unstructured":"Zhang K, Jiang M, Fang Y. The drama of wallerian degeneration: The cast, crew, and script. Annu Rev Genet 2021, 55: 93\u2013113.","journal-title":"Annu Rev Genet"},{"key":"1564_CR30","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1460-9568.1993.tb00531.x","volume":"5","author":"NE Ziv","year":"1993","unstructured":"Ziv NE, Spira ME. Spatiotemporal distribution of Ca2+ following axotomy and throughout the recovery process of cultured Aplysia neurons. Eur J Neurosci 1993, 5: 657\u2013668.","journal-title":"Eur J Neurosci"},{"key":"1564_CR31","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1523\/JNEUROSCI.15-10-06445.1995","volume":"15","author":"EB George","year":"1995","unstructured":"George EB, Glass JD, Griffin JW. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci 1995, 15: 6445\u20136452.","journal-title":"J Neurosci"},{"key":"1564_CR32","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1523\/JNEUROSCI.5464-09.2010","volume":"30","author":"A Ghosh-Roy","year":"2010","unstructured":"Ghosh-Roy A, Wu Z, Goncharov A, Jin Y, Chisholm AD. Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase. J Neurosci 2010, 30: 3175\u20133183.","journal-title":"J Neurosci"},{"key":"1564_CR33","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/biom14020183","volume":"14","author":"M Lisek","year":"2024","unstructured":"Lisek M, Tomczak J, Boczek T, Zylinska L. Calcium-associated proteins in neuroregeneration. Biomolecules 2024, 14: 183.","journal-title":"Biomolecules"},{"key":"1564_CR34","doi-asserted-by":"publisher","first-page":"13344","DOI":"10.3390\/ijms222413344","volume":"22","author":"A Khaitin","year":"2021","unstructured":"Khaitin A. Calcium in neuronal and glial response to axotomy. Int J Mol Sci 2021, 22: 13344.","journal-title":"Int J Mol Sci"},{"key":"1564_CR35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.redox.2018.11.003","volume":"20","author":"CT Madreiter-Sokolowski","year":"2019","unstructured":"Madreiter-Sokolowski CT, Waldeck-Weiermair M, Bourguignon MP, Villeneuve N, Gottschalk B, Klec C, et al. Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox Biol 2019, 20: 458\u2013466.","journal-title":"Redox Biol"},{"key":"1564_CR36","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41419-017-0105-5","volume":"9","author":"J Janikiewicz","year":"2018","unstructured":"Janikiewicz J, Szyma\u0144ski J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszy\u0144ski J, et al. Mitochondria-associated membranes in aging and senescence: Structure, function, and dynamics. Cell Death Dis 2018, 9: 332.","journal-title":"Cell Death Dis"},{"key":"1564_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101678","volume":"36","author":"CT Madreiter-Sokolowski","year":"2020","unstructured":"Madreiter-Sokolowski CT, Thomas C, Ristow M. Interrelation between ROS and Ca2+ in aging and age-related diseases. Redox Biol 2020, 36: 101678.","journal-title":"Redox Biol"},{"key":"1564_CR38","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/cells9010204","volume":"9","author":"J Alvarez","year":"2020","unstructured":"Alvarez J, Alvarez-Illera P, Garc\u00eda-Casas P, Fonteriz RI, Montero M. The role of Ca2+ signaling in aging and neurodegeneration: Insights from Caenorhabditis elegans models. Cells 2020, 9: 204.","journal-title":"Cells"},{"key":"1564_CR39","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","volume":"28","author":"G Csord\u00e1s","year":"2018","unstructured":"Csord\u00e1s G, Weaver D, Hajn\u00f3czky G. Endoplasmic reticulum-mitochondrial contactology: Structure and signaling functions. Trends Cell Biol 2018, 28: 523\u2013540.","journal-title":"Trends Cell Biol"},{"key":"1564_CR40","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1146\/annurev.physiol.67.032003.154341","volume":"67","author":"C Hartzell","year":"2005","unstructured":"Hartzell C, Putzier I, Arreola J. Calcium-activated chloride channels. Annu Rev Physiol 2005, 67: 719\u2013758.","journal-title":"Annu Rev Physiol"},{"key":"1564_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102946","volume":"299","author":"AL Hsu","year":"2023","unstructured":"Hsu AL, Ben-Johny M. Ion channel chameleons: Switching ion selectivity by alternative splicing. J Biol Chem 2023, 299: 102946.","journal-title":"J Biol Chem"},{"key":"1564_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113177","volume":"326","author":"HY Shin","year":"2020","unstructured":"Shin HY, Kim K, Kwon MJ, Oh YJ, Kim EH, Kim HS, et al. Alteration in global DNA methylation status following preconditioning injury influences axon growth competence of the sensory neurons. Exp Neurol 2020, 326: 113177.","journal-title":"Exp Neurol"},{"key":"1564_CR43","doi-asserted-by":"crossref","unstructured":"Lie PPY, Yoo L, Goulbourne CN, Berg MJ, Stavrides P, Huo C, et al. Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function. Sci Adv 2022, 8: eabj5716.","DOI":"10.1126\/sciadv.abj5716"},{"key":"1564_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2014.03.004","volume":"56","author":"E De Marchi","year":"2014","unstructured":"De Marchi E, Bonora M, Giorgi C, Pinton P. The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium 2014, 56: 1\u201313.","journal-title":"Cell Calcium"},{"key":"1564_CR45","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1523\/JNEUROSCI.17-10-03568.1997","volume":"17","author":"NE Ziv","year":"1997","unstructured":"Ziv NE, Spira ME. Localized and transient elevations of intracellular Ca2+ induce the dedifferentiation of axonal segments into growth cones. J Neurosci 1997, 17: 3568\u20133579.","journal-title":"J Neurosci"},{"key":"1564_CR46","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.devcel.2022.05.019","volume":"57","author":"L Tao","year":"2022","unstructured":"Tao L, Coakley S, Shi R, Shen K. Dendrites use mechanosensitive channels to proofread ligand-mediated neurite extension during morphogenesis. Dev Cell 2022, 57: 1615-1629.e3.","journal-title":"Dev Cell"},{"key":"1564_CR47","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mcn.2017.07.006","volume":"84","author":"RJ Gasperini","year":"2017","unstructured":"Gasperini RJ, Pavez M, Thompson AC, Mitchell CB, Hardy H, Young KM, et al. How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding? Mol Cell Neurosci 2017, 84: 29\u201335.","journal-title":"Mol Cell Neurosci"},{"key":"1564_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nrn3176","volume":"13","author":"F Bradke","year":"2012","unstructured":"Bradke F, Fawcett JW, Spira ME. Assembly of a new growth cone after axotomy: The precursor to axon regeneration. Nat Rev Neurosci 2012, 13: 183\u2013193.","journal-title":"Nat Rev Neurosci"},{"key":"1564_CR49","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/jnr.23530","volume":"93","author":"G Fedorenko","year":"2015","unstructured":"Fedorenko G, Neginskaya M, Fedorenko A, Uzdensky A. The paired neuroglial and interglial membranes in the crayfish stretch receptor and their local disorganization. J Neurosci Res 2015, 93: 707\u2013713.","journal-title":"J Neurosci Res"},{"key":"1564_CR50","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neuron.2019.01.050","volume":"102","author":"Y Song","year":"2019","unstructured":"Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, et al. The mechanosensitive ion channel piezo inhibits axon regeneration. Neuron 2019, 102: 373-389.e6.","journal-title":"Neuron"},{"key":"1564_CR51","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neulet.2019.02.016","volume":"699","author":"AR Wang","year":"2019","unstructured":"Wang AR, Hu MZ, Zhang ZL, Zhao ZY, Li YB, Liu B. Fastigial nucleus electrostimulation promotes axonal regeneration after experimental stroke via cAMP\/PKA pathway. Neurosci Lett 2019, 699: 177\u2013183.","journal-title":"Neurosci Lett"},{"key":"1564_CR52","doi-asserted-by":"publisher","first-page":"E6338","DOI":"10.3390\/ijms20246338","volume":"20","author":"T Boczek","year":"2019","unstructured":"Boczek T, Radzik T, Ferenc B, Zylinska L. The puzzling role of neuron-specific PMCA isoforms in the aging process. Int J Mol Sci 2019, 20: E6338.","journal-title":"Int J Mol Sci"},{"key":"1564_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2020.107230","volume":"173","author":"SJ Moore","year":"2020","unstructured":"Moore SJ, Murphy GG. The role of L-type calcium channels in neuronal excitability and aging. Neurobiol Learn Mem 2020, 173: 107230.","journal-title":"Neurobiol Learn Mem"},{"key":"1564_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101951","volume":"88","author":"H Wu","year":"2023","unstructured":"Wu H, Chen W, Chen Z, Li X, Wang M. Novel tumor therapy strategies targeting endoplasmic reticulum-mitochondria signal pathways. Ageing Res Rev 2023, 88: 101951.","journal-title":"Ageing Res Rev"},{"key":"1564_CR55","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3390\/ijms21041549","volume":"21","author":"M Calvo-Rodriguez","year":"2020","unstructured":"Calvo-Rodriguez M, Hernando-P\u00e9rez E, L\u00f3pez-V\u00e1zquez S, N\u00fa\u00f1ez J, Villalobos C, N\u00fa\u00f1ez L. Remodeling of intracellular Ca2+ homeostasis in rat hippocampal neurons aged in vitro. Int J Mol Sci 2020, 21: 1549.","journal-title":"Int J Mol Sci"},{"key":"1564_CR56","first-page":"145","volume":"14","author":"S Bai","year":"2022","unstructured":"Bai S, Lan Y, Fu S, Cheng H, Lu Z, Liu G. Connecting calcium-based nanomaterials and cancer: From diagnosis to therapy. Nanomicro Lett 2022, 14: 145.","journal-title":"Nanomicro Lett"},{"key":"1564_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412311","volume":"12","author":"H Zhao","year":"2025","unstructured":"Zhao H, Chen S, Cao N, Wu W, Liu G, Gao J, et al. Berberine is a novel mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly. Adv Sci (Weinh) 2025, 12: e2412311.","journal-title":"Adv Sci (Weinh)"},{"key":"1564_CR58","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.actbio.2025.05.060","volume":"201","author":"Z Li","year":"2025","unstructured":"Li Z, Tang X, Yang H, Lu L, Zhang J, Liu Y. Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair. Acta Biomater 2025, 201: 171\u2013186.","journal-title":"Acta Biomater"},{"key":"1564_CR59","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev-biochem-080411-121438","volume":"82","author":"D Atlas","year":"2013","unstructured":"Atlas D. The voltage-gated calcium channel functions as the molecular switch of synaptic transmission. Annu Rev Biochem 2013, 82: 607\u2013635.","journal-title":"Annu Rev Biochem"},{"key":"1564_CR60","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/acel.12157","volume":"13","author":"FL N\u00fa\u00f1ez-Santana","year":"2014","unstructured":"N\u00fa\u00f1ez-Santana FL, Oh MM, Antion MD, Lee A, Hell JW, Disterhoft JF. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell 2014, 13: 111\u2013120.","journal-title":"Aging Cell"},{"key":"1564_CR61","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1124\/jpet.114.216143","volume":"352","author":"E Molina-Campos","year":"2015","unstructured":"Molina-Campos E, Xu Y, Atchison WD. Age-dependent contribution of P\/Q- and R-type Ca2+ channels to neuromuscular transmission in lethargic mice. J Pharmacol Exp Ther 2015, 352: 395\u2013404.","journal-title":"J Pharmacol Exp Ther"},{"key":"1564_CR62","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1038\/s41598-018-25195-0","volume":"8","author":"A Lam","year":"2018","unstructured":"Lam A, Karekar P, Shah K, Hariharan G, Fleyshman M, Kaur H, et al. Drosophila voltage-gated calcium channel \u03b11-subunits regulate cardiac function in the aging heart. Sci Rep 2018, 8: 6910.","journal-title":"Sci Rep"},{"key":"1564_CR63","doi-asserted-by":"publisher","first-page":"8810","DOI":"10.18632\/aging.102284","volume":"11","author":"JM Kim","year":"2019","unstructured":"Kim JM, Heo HS, Shin SC, Kwon HK, Lee JC, Sung ES, et al. Increased calcium channel in the Lamina propria of aging rat. Aging (Albany NY) 2019, 11: 8810\u20138824.","journal-title":"Aging (Albany NY)"},{"key":"1564_CR64","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s13365-017-0588-y","volume":"24","author":"CE Khodr","year":"2018","unstructured":"Khodr CE, Chen L, Al-Harthi L, Hu XT. Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol 2018, 24: 113\u2013118.","journal-title":"J Neurovirol"},{"key":"1564_CR65","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1096\/fj.04-2549fje","volume":"19","author":"MP Kurnellas","year":"2005","unstructured":"Kurnellas MP, Nicot A, Shull GE, Elkabes S. Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: A potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB J 2005, 19: 298\u2013300.","journal-title":"FASEB J"},{"key":"1564_CR66","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1471-4159.2012.07918.x","volume":"123","author":"L Jiang","year":"2012","unstructured":"Jiang L, Bechtel MD, Galeva NA, Williams TD, Michaelis EK, Michaelis ML. Decreases in plasma membrane Ca2\u207a-ATPase in brain synaptic membrane rafts from aged rats. J Neurochem 2012, 123: 689\u2013699.","journal-title":"J Neurochem"},{"key":"1564_CR67","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.bbagrm.2017.01.012","volume":"1860","author":"T Boczek","year":"2017","unstructured":"Boczek T, Lisek M, Ferenc B, Zylinska L. Cross talk among PMCA calcineurin and NFAT transcription factors in control of calmodulin gene expression in differentiating PC12 cells. Biochim Biophys Acta Gene Regul Mech 2017, 1860: 502\u2013515.","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"1564_CR68","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12868-022-00695-y","volume":"23","author":"DH O\u2019Day","year":"2022","unstructured":"O\u2019Day DH, Huber RJ. Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases. BMC Neurosci 2022, 23: 10.","journal-title":"BMC Neurosci"},{"key":"1564_CR69","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neulet.2017.11.005","volume":"663","author":"T Cal\u00ec","year":"2018","unstructured":"Cal\u00ec T, Brini M, Carafoli E. The PMCA pumps in genetically determined neuronal pathologies. Neurosci Lett 2018, 663: 2\u201311.","journal-title":"Neurosci Lett"},{"key":"1564_CR70","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1744-8069-8-46","volume":"8","author":"G Gemes","year":"2012","unstructured":"Gemes G, Oyster KD, Pan B, Wu HE, Bangaru MLY, Tang Q, et al. Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons. Mol Pain 2012, 8: 46.","journal-title":"Mol Pain"},{"key":"1564_CR71","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/ijms22010037","volume":"22","author":"R Qaisar","year":"2020","unstructured":"Qaisar R, Pharaoh G, Bhaskaran S, Xu H, Ranjit R, Bian J, et al. Restoration of sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity prevents age-related muscle atrophy and weakness in mice. Int J Mol Sci 2020, 22: 37.","journal-title":"Int J Mol Sci"},{"key":"1564_CR72","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1021\/tx700108w","volume":"20","author":"ES Dremina","year":"2007","unstructured":"Dremina ES, Sharov VS, Davies MJ, Sch\u00f6neich C. Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides. Chem Res Toxicol 2007, 20: 1462\u20131469.","journal-title":"Chem Res Toxicol"},{"key":"1564_CR73","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1042\/BJ20051214","volume":"394","author":"VS Sharov","year":"2006","unstructured":"Sharov VS, Dremina ES, Galeva NA, Williams TD, Sch\u00f6neich C. Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: Selective protein oxidation during biological aging. Biochem J 2006, 394: 605\u2013615.","journal-title":"Biochem J"},{"key":"1564_CR74","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13395-021-00280-7","volume":"11","author":"H Xu","year":"2021","unstructured":"Xu H, Van Remmen H. The SarcoEndoplasmic reticulum calcium ATPase (SERCA) pump: A potential target for intervention in aging and skeletal muscle pathologies. Skelet Muscle 2021, 11: 25.","journal-title":"Skelet Muscle"},{"key":"1564_CR75","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.molcel.2020.10.015","volume":"80","author":"JK Byun","year":"2020","unstructured":"Byun JK, Park M, Lee S, Yun JW, Lee J, Kim JS, et al. Inhibition of glutamine utilization synergizes with immune checkpoint inhibitor to promote antitumor immunity. Mol Cell 2020, 80: 592-606.e8.","journal-title":"Mol Cell"},{"key":"1564_CR76","doi-asserted-by":"publisher","first-page":"1202167","DOI":"10.3389\/fnins.2023.1202167","volume":"17","author":"GA Johnson","year":"2023","unstructured":"Johnson GA, Krishnamoorthy RR, Stankowska DL. Modulating mitochondrial calcium channels (TRPM2\/MCU\/NCX) as a therapeutic strategy for neurodegenerative disorders. Front Neurosci 2023, 17: 1202167.","journal-title":"Front Neurosci"},{"key":"1564_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101955","volume":"88","author":"Y Guo","year":"2023","unstructured":"Guo Y, Guan T, Shafiq K, Yu Q, Jiao X, Na D, et al. Mitochondrial dysfunction in aging. Ageing Res Rev 2023, 88: 101955.","journal-title":"Ageing Res Rev"},{"key":"1564_CR78","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104705","volume":"40","author":"M Onishi","year":"2021","unstructured":"Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K. Molecular mechanisms and physiological functions of mitophagy. EMBO J 2021, 40: e104705.","journal-title":"EMBO J"},{"key":"1564_CR79","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","volume":"61","author":"N Sun","year":"2016","unstructured":"Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell 2016, 61: 654\u2013666.","journal-title":"Mol Cell"},{"key":"1564_CR80","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","volume":"71","author":"M Brini","year":"2014","unstructured":"Brini M, Cal\u00ec T, Ottolini D, Carafoli E. Neuronal calcium signaling: Function and dysfunction. Cell Mol Life Sci 2014, 71: 2787\u20132814.","journal-title":"Cell Mol Life Sci"},{"key":"1564_CR81","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.852181","volume":"15","author":"B Kievit","year":"2022","unstructured":"Kievit B, Johnstone AD, Gibon J, Barker PA. Mitochondrial reactive oxygen species mediate activation of TRPV1 and calcium entry following peripheral sensory axotomy. Front Mol Neurosci 2022, 15: 852181.","journal-title":"Front Mol Neurosci"},{"key":"1564_CR82","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12974-022-02405-1","volume":"19","author":"J Wei","year":"2022","unstructured":"Wei J, Su W, Zhao Y, Wei Z, Hua Y, Xue P, et al. Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury. J Neuroinflammation 2022, 19: 32.","journal-title":"J Neuroinflammation"},{"key":"1564_CR83","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3389\/fnmol.2019.00132","volume":"12","author":"V Castelli","year":"2019","unstructured":"Castelli V, Benedetti E, Antonosante A, Catanesi M, Pitari G, Ippoliti R, et al. Neuronal cells rearrangement during aging and neurodegenerative disease: Metabolism, oxidative stress and organelles dynamic. Front Mol Neurosci 2019, 12: 132.","journal-title":"Front Mol Neurosci"},{"key":"1564_CR84","doi-asserted-by":"crossref","unstructured":"Balderas E, Lee SHJ, Rai NK, Mollinedo DM, Duron HE, Chaudhuri D. Mitochondrial calcium regulation of cardiac metabolism in health and disease. Physiology (Bethesda) 2024, 39: 0.","DOI":"10.1152\/physiol.00014.2024"},{"key":"1564_CR85","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1161\/CIRCRESAHA.123.323882","volume":"134","author":"A Mendoza","year":"2024","unstructured":"Mendoza A, Patel P, Robichaux D, Ramirez D, Karch J. Inhibition of the mPTP and lipid peroxidation is additively protective against I\/R injury. Circ Res 2024, 134: 1292\u20131305.","journal-title":"Circ Res"},{"key":"1564_CR86","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203106","volume":"12","author":"P He","year":"2023","unstructured":"He P, Liu F, Li M, Ren M, Wang X, Deng Y, et al. Mitochondrial calcium ion nanogluttons alleviate periodontitis via controlling mPTPs. Adv Healthc Mater 2023, 12: e2203106.","journal-title":"Adv Healthc Mater"},{"key":"1564_CR87","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3390\/cells10030649","volume":"10","author":"K Jia","year":"2021","unstructured":"Jia K, Du H. Mitochondrial permeability transition: A pore intertwines brain aging and Alzheimer\u2019s disease. Cells 2021, 10: 649.","journal-title":"Cells"},{"key":"1564_CR88","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2022.876785","volume":"3","author":"HE Collins","year":"2022","unstructured":"Collins HE, Zhang D, Chatham JC. STIM and orai mediated regulation of calcium signaling in age-related diseases. Front Aging 2022, 3: 876785.","journal-title":"Front Aging"},{"key":"1564_CR89","doi-asserted-by":"publisher","first-page":"H83","DOI":"10.1152\/ajpheart.00588.2017","volume":"315","author":"M Mohis","year":"2018","unstructured":"Mohis M, Edwards S, Ryan S, Rizvi F, Jamil Tajik A, Jahangir A, et al. Aging-related increase in store-operated Ca2+ influx in human ventricular fibroblasts. Am J Physiol Heart Circ Physiol 2018, 315: H83\u2013H91.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1564_CR90","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3390\/cells13151301","volume":"13","author":"G Bastioli","year":"2024","unstructured":"Bastioli G, Piccirillo S, Graciotti L, Carone M, Sprega G, Taoussi O, et al. Calcium deregulation in neurodegeneration and neuroinflammation in Parkinson\u2019s disease: Role of calcium-storing organelles and sodium-calcium exchanger. Cells 2024, 13: 1301.","journal-title":"Cells"},{"key":"1564_CR91","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.7150\/thno.119712","volume":"15","author":"N Wang","year":"2025","unstructured":"Wang N, Li W, Yang T, Li B, Meng C, Zhou X, et al. Targeting CB1R rewires Ca2+-dependent mitophagy to promote nerve regeneration. Theranostics 2025, 15: 8873\u20138896.","journal-title":"Theranostics"},{"key":"1564_CR92","doi-asserted-by":"crossref","unstructured":"Li Y, Pazyra-Murphy MF, Avizonis D, de S\u00e1 Tavares Russo M, Tang S, Chen CY, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol 2022, 221: e202106080.","DOI":"10.1083\/jcb.202106080"},{"key":"1564_CR93","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202006035","volume":"220","author":"G Chandra","year":"2021","unstructured":"Chandra G, Sreetama SC, M\u00e1zala DAG, Charton K, VanderMeulen JH, Richard I, et al. Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair. J Cell Biol 2021, 220: e202006035.","journal-title":"J Cell Biol"},{"key":"1564_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10565-022-09717-1","volume":"39","author":"Y Cao","year":"2023","unstructured":"Cao Y, Xiong Y, Sun H, Wang Z. Neurorescuing effect of Cinacalcet against hypercalcemia-induced nerve injury in chronic kidney disease via TRAF2\/cIAP1\/KLF2\/SERPINA3 signal axis. Cell Biol Toxicol 2023, 39: 1\u201317.","journal-title":"Cell Biol Toxicol"},{"key":"1564_CR95","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41419-021-04022-x","volume":"12","author":"Y Cao","year":"2021","unstructured":"Cao Y, Chen X, Sun H. Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2\/KLF2\/CXCL1 axis. Cell Death Dis 2021, 12: 819.","journal-title":"Cell Death Dis"},{"key":"1564_CR96","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.neuron.2013.08.034","volume":"80","author":"J Yang","year":"2013","unstructured":"Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, et al. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron 2013, 80: 1175\u20131189.","journal-title":"Neuron"},{"key":"1564_CR97","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.bbrc.2012.06.024","volume":"423","author":"M Kang","year":"2012","unstructured":"Kang M, Chung KY. PKC-\u03b5 mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes. Biochem Biophys Res Commun 2012, 423: 600\u2013605.","journal-title":"Biochem Biophys Res Commun"},{"key":"1564_CR98","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14349","volume":"24","author":"J Zhao","year":"2025","unstructured":"Zhao J, Li M, Hu Q, Donoghue P, Jiang S, Li J, et al. CaMKII\u03b1-TARP\u03b38 signaling mediates hippocampal synaptic impairment in aging. Aging Cell 2025, 24: e14349.","journal-title":"Aging Cell"},{"key":"1564_CR99","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.2147\/JPR.S382692","volume":"15","author":"ZH Fang","year":"2022","unstructured":"Fang ZH, Liao HL, Tang QF, Liu YJ, Zhang YY, Lin J, et al. Interactions among non-coding RNAs and mRNAs in the trigeminal ganglion associated with neuropathic pain. J Pain Res 2022, 15: 2967\u20132988.","journal-title":"J Pain Res"},{"key":"1564_CR100","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200006","volume":"9","author":"M Winklehner","year":"2022","unstructured":"Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, et al. Paraneoplastic cerebellar degeneration with P\/Q-VGCC vs yo autoantibodies. Neurol Neuroimmunol Neuroinflamm 2022, 9: e200006.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"1564_CR101","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203824119","volume":"119","author":"HMC Choi","year":"2022","unstructured":"Choi HMC, Li Y, Suraj D, Hsia RC, Sarkar C, Wu J, et al. Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury. Proc Natl Acad Sci U S A 2022, 119: e2203824119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR102","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-cellbio-100818-125242","volume":"35","author":"AKH Stavoe","year":"2019","unstructured":"Stavoe AKH, Holzbaur ELF. Autophagy in neurons. Annu Rev Cell Dev Biol 2019, 35: 477\u2013500.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1564_CR103","doi-asserted-by":"publisher","first-page":"16219","DOI":"10.3390\/ijms242216219","volume":"24","author":"DK Yon","year":"2023","unstructured":"Yon DK, Kim YJ, Park DC, Jung SY, Kim SS, Yeo JH, et al. Induction of autophagy and its role in peripheral nerve regeneration after peripheral nerve injury. Int J Mol Sci 2023, 24: 16219.","journal-title":"Int J Mol Sci"},{"key":"1564_CR104","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1080\/15548627.2023.2236485","volume":"19","author":"H Tsong","year":"2023","unstructured":"Tsong H, Holzbaur EL, Stavoe AK. Aging differentially affects axonal autophagosome formation and maturation. Autophagy 2023, 19: 3079\u20133095.","journal-title":"Autophagy"},{"key":"1564_CR105","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14177","volume":"23","author":"X Wu","year":"2024","unstructured":"Wu X, Yang L, Li Z, Gu C, Jin K, Luo A, et al. Aging-associated decrease of PGC-1\u03b1 promotes pain chronification. Aging Cell 2024, 23: e14177.","journal-title":"Aging Cell"},{"key":"1564_CR106","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/15548627.2021.1943177","volume":"18","author":"C Deneubourg","year":"2022","unstructured":"Deneubourg C, Ramm M, Smith LJ, Baron O, Singh K, Byrne SC, et al. The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy. Autophagy 2022, 18: 496\u2013517.","journal-title":"Autophagy"},{"key":"1564_CR107","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/15548627.2019.1695401","volume":"16","author":"AKH Stavoe","year":"2020","unstructured":"Stavoe AKH, Holzbaur ELF. Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2. Autophagy 2020, 16: 371\u2013372.","journal-title":"Autophagy"},{"key":"1564_CR108","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/s41556-018-0235-8","volume":"20","author":"AM Leidal","year":"2018","unstructured":"Leidal AM, Levine B, Debnath J. Autophagy and the cell biology of age-related disease. Nat Cell Biol 2018, 20: 1338\u20131348.","journal-title":"Nat Cell Biol"},{"key":"1564_CR109","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1080\/15548627.2019.1635384","volume":"16","author":"A Larabi","year":"2020","unstructured":"Larabi A, Barnich N, Nguyen HTT. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy 2020, 16: 38\u201351.","journal-title":"Autophagy"},{"key":"1564_CR110","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ebiom.2018.08.035","volume":"35","author":"M Zhou","year":"2018","unstructured":"Zhou M, Xu W, Wang J, Yan J, Shi Y, Zhang C, et al. Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-\u03baB pathway quenches intestinal inflammation and oxidative stress injury. EBioMedicine 2018, 35: 345\u2013360.","journal-title":"EBioMedicine"},{"key":"1564_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101636","volume":"78","author":"L Culig","year":"2022","unstructured":"Culig L, Chu X, Bohr VA. Neurogenesis in aging and age-related neurodegenerative diseases. Ageing Res Rev 2022, 78: 101636.","journal-title":"Ageing Res Rev"},{"key":"1564_CR112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213207120","volume":"120","author":"S Noureddine","year":"2023","unstructured":"Noureddine S, Nie J, Schneider A, Menon V, Fliesen Z, Dhahbi J, et al. microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling. Proc Natl Acad Sci U S A 2023, 120: e2213207120.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR113","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.arr.2016.04.003","volume":"28","author":"A Salminen","year":"2016","unstructured":"Salminen A, Kaarniranta K, Kauppinen A. Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res Rev 2016, 28: 15\u201326.","journal-title":"Ageing Res Rev"},{"key":"1564_CR114","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3390\/biom13040686","volume":"13","author":"P Silwal","year":"2023","unstructured":"Silwal P, Nguyen-Thai AM, Mohammad HA, Wang Y, Robbins PD, Lee JY, et al. Cellular senescence in intervertebral disc aging and degeneration: Molecular mechanisms and potential therapeutic opportunities. Biomolecules 2023, 13: 686.","journal-title":"Biomolecules"},{"key":"1564_CR115","doi-asserted-by":"publisher","first-page":"11586","DOI":"10.3390\/ijms241411586","volume":"24","author":"NA Muraleva","year":"2023","unstructured":"Muraleva NA, Kolosova NG. P38 MAPK signaling in the retina: Effects of aging and age-related macular degeneration. Int J Mol Sci 2023, 24: 11586.","journal-title":"Int J Mol Sci"},{"key":"1564_CR116","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1096\/fj.201801234R","volume":"33","author":"A Liu","year":"2019","unstructured":"Liu A, Yang J, Hu Q, Dirsch O, Dahmen U, Zhang C, et al. Young plasma attenuates age-dependent liver ischemia reperfusion injury. FASEB J 2019, 33: 3063\u20133073.","journal-title":"FASEB J"},{"key":"1564_CR117","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3390\/cells10020464","volume":"10","author":"G Di Benedetto","year":"2021","unstructured":"Di Benedetto G, Iannucci LF, Surdo NC, Zanin S, Conca F, Grisan F, et al. Compartmentalized signaling in aging and neurodegeneration. Cells 2021, 10: 464.","journal-title":"Cells"},{"key":"1564_CR118","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/j.1474-9726.2012.00829.x","volume":"11","author":"K Twumasi-Boateng","year":"2012","unstructured":"Twumasi-Boateng K, Wang TW, Tsai L, Lee KH, Salehpour A, Bhat S, et al. An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell 2012, 11: 659\u2013667.","journal-title":"Aging Cell"},{"key":"1564_CR119","doi-asserted-by":"publisher","first-page":"4363","DOI":"10.1007\/s10571-023-01431-8","volume":"43","author":"W Huang","year":"2023","unstructured":"Huang W, Yi S, Zhao L. Genetic features of young and aged animals after peripheral nerve injury: Implications for diminished regeneration capacity. Cell Mol Neurobiol 2023, 43: 4363\u20134375.","journal-title":"Cell Mol Neurobiol"},{"key":"1564_CR120","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1038\/s41467-021-23923-1","volume":"12","author":"F Hu","year":"2021","unstructured":"Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun 2021, 12: 3651.","journal-title":"Nat Commun"},{"issue":"4","key":"1564_CR121","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.309","volume":"2023","author":"Y Guo","year":"2020","unstructured":"Guo Y, Zhang X, Li J, Zhou Z, Zhu S, Liu W, et al. TRAF6 regulates autophagy and apoptosis of melanoma cells through c-Jun\/ATG16L2 signaling pathway. MedComm 2020, 2023(4): e309.","journal-title":"MedComm"},{"key":"1564_CR122","doi-asserted-by":"publisher","first-page":"182","DOI":"10.2174\/1566524023666230120102718","volume":"24","author":"BA Marzoog","year":"2024","unstructured":"Marzoog BA. Autophagy as an anti-senescent in aging neurocytes. Curr Mol Med 2024, 24: 182\u2013190.","journal-title":"Curr Mol Med"},{"key":"1564_CR123","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.conb.2020.02.012","volume":"63","author":"MD Figley","year":"2020","unstructured":"Figley MD, DiAntonio A. The SARM1 axon degeneration pathway: Control of the NAD+ metabolome regulates axon survival in health and disease. Curr Opin Neurobiol 2020, 63: 59\u201366.","journal-title":"Curr Opin Neurobiol"},{"key":"1564_CR124","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.3390\/ijerph19031627","volume":"19","author":"L Aquilanti","year":"2022","unstructured":"Aquilanti L, Mascitti M, Togni L, Contaldo M, Rappelli G, Santarelli A. A systematic review on nerve-related adverse effects following mandibular nerve block anesthesia. Int J Environ Res Public Health 2022, 19: 1627.","journal-title":"Int J Environ Res Public Health"},{"key":"1564_CR125","doi-asserted-by":"publisher","first-page":"390","DOI":"10.14336\/AD.2023.0516-1","volume":"15","author":"X Miao","year":"2024","unstructured":"Miao X, Wu Q, Du S, Xiang L, Zhou S, Zhu J, et al. SARM1 promotes neurodegeneration and memory impairment in mouse models of Alzheimer\u2019s disease. Aging Dis 2024, 15: 390\u2013407.","journal-title":"Aging Dis"},{"key":"1564_CR126","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202112021","volume":"221","author":"A H\u00f6ke","year":"2022","unstructured":"H\u00f6ke A. cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel. J Cell Biol 2022, 221: e202112021.","journal-title":"J Cell Biol"},{"key":"1564_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107786","volume":"216","author":"X Wang","year":"2025","unstructured":"Wang X, Sun Y, Yu H, Xue C, Pei X, Chen Y, et al. The regulation of microglia by aging and autophagy in multiple sclerosis. Pharmacol Res 2025, 216: 107786.","journal-title":"Pharmacol Res"},{"key":"1564_CR128","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.4103\/NRR.NRR-D-23-01948","volume":"20","author":"Y Chen","year":"2025","unstructured":"Chen Y, Deng H, Zhang N. Autophagy-targeting modulation to promote peripheral nerve regeneration. Neural Regen Res 2025, 20: 1864\u20131882.","journal-title":"Neural Regen Res"},{"key":"1564_CR129","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.expneurol.2016.07.010","volume":"284","author":"J Scheib","year":"2016","unstructured":"Scheib J, H\u00f6ke A. Impaired regeneration in aged nerves: Clearing out the old to make way for the new. Exp Neurol 2016, 284: 79\u201383.","journal-title":"Exp Neurol"},{"key":"1564_CR130","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1529-8027.2000.00026.x","volume":"5","author":"E Verd\u00fa","year":"2000","unstructured":"Verd\u00fa E, Ceballos D, Vilches JJ, Navarro X. Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst 2000, 5: 191\u2013208.","journal-title":"J Peripher Nerv Syst"},{"key":"1564_CR131","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.neuron.2014.06.016","volume":"83","author":"MW Painter","year":"2014","unstructured":"Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, et al. Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration. Neuron 2014, 83: 331\u2013343.","journal-title":"Neuron"},{"key":"1564_CR132","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","volume":"162","author":"AL Cattin","year":"2015","unstructured":"Cattin AL, Burden JJ, Van Emmenis L, MacKenzie FE, Hoving JJA, Garcia Calavia N, et al. Macrophage-induced blood vessels guide schwann cell-mediated regeneration of peripheral nerves. Cell 2015, 162: 1127\u20131139.","journal-title":"Cell"},{"key":"1564_CR133","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1113\/JP270874","volume":"594","author":"KR Jessen","year":"2016","unstructured":"Jessen KR, Mirsky R. The repair Schwann cell and its function in regenerating nerves. J Physiol 2016, 594: 3521\u20133531.","journal-title":"J Physiol"},{"key":"1564_CR134","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202317907","volume":"15","author":"A Fuentes-Flores","year":"2023","unstructured":"Fuentes-Flores A, Geronimo-Olvera C, Girardi K, Necu\u00f1ir-Ibarra D, Patel SK, Bons J, et al. Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury. EMBO Mol Med 2023, 15: e17907.","journal-title":"EMBO Mol Med"},{"key":"1564_CR135","doi-asserted-by":"crossref","unstructured":"Wang P, Wang R, Huo Y, Peng Y, Fu C, Hu Y, et al. Partial reprogramming in senescent schwann cells enhances peripheral nerve regeneration via restoration of stress granule homeostasis. Adv Sci (Weinh) 2025: e11019.","DOI":"10.1002\/advs.202511019"},{"key":"1564_CR136","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62232","volume":"10","author":"LJ Wagstaff","year":"2021","unstructured":"Wagstaff LJ, Gomez-Sanchez JA, Fazal SV, Otto GW, Kilpatrick AM, Michael K, et al. Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun. Elife 2021, 10: e62232.","journal-title":"Elife"},{"key":"1564_CR137","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.conb.2017.10.022","volume":"47","author":"MW Painter","year":"2017","unstructured":"Painter MW. Aging Schwann cells: Mechanisms, implications, future directions. Curr Opin Neurobiol 2017, 47: 203\u2013208.","journal-title":"Curr Opin Neurobiol"},{"key":"1564_CR138","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jss.2023.03.017","volume":"288","author":"KC Maita","year":"2023","unstructured":"Maita KC, Garcia JP, Avila FR, Torres-Guzman RA, Ho O, Chini CCS, et al. Evaluation of the aging effect on peripheral nerve regeneration: A systematic review. J Surg Res 2023, 288: 329\u2013340.","journal-title":"J Surg Res"},{"key":"1564_CR139","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/brain\/awt327","volume":"137","author":"A Schulz","year":"2014","unstructured":"Schulz A, Kyselyova A, Baader SL, Jung MJ, Zoch A, Mautner VF, et al. Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. Brain 2014, 137: 420\u2013432.","journal-title":"Brain"},{"key":"1564_CR140","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/MAO.0b013e3181d2777f","volume":"31","author":"Z Ahmad","year":"2010","unstructured":"Ahmad Z, Brown CM, Patel AK, Ryan AF, Ongkeko R, Doherty JK. Merlin knockdown in human schwann cells: Clues to vestibular schwannoma tumorigenesis. Otol Neurotol 2010, 31: 460\u2013466.","journal-title":"Otol Neurotol"},{"key":"1564_CR141","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12951-022-01337-5","volume":"20","author":"T Liu","year":"2022","unstructured":"Liu T, Wang Y, Lu L, Liu Y. SPIONs mediated magnetic actuation promotes nerve regeneration by inducing and maintaining repair-supportive phenotypes in Schwann cells. J Nanobiotechnology 2022, 20: 159.","journal-title":"J Nanobiotechnology"},{"key":"1564_CR142","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112802","volume":"42","author":"M Wu","year":"2023","unstructured":"Wu M, Li M, Liu W, Yan M, Li L, Ding W, et al. Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis. Cell Rep 2023, 42: 112802.","journal-title":"Cell Rep"},{"key":"1564_CR143","first-page":"0825","volume":"8","author":"F Shan","year":"2025","unstructured":"Shan F, Yao X, Zhang Q, Li R, Kong L, Zheng Q, et al. NMDA receptors coordinate metabolic reprogramming and mitophagy in schwann cells to promote peripheral nerve regeneration. Research (Wash D C) 2025, 8: 0825.","journal-title":"Research (Wash D C)"},{"key":"1564_CR144","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414547","volume":"12","author":"W Li","year":"2025","unstructured":"Li W, Yang T, Wang N, Li B, Meng C, Yu K, et al. Maladaptive peripheral ketogenesis in schwann cells mediated by CB1R contributes to diabetic neuropathy. Adv Sci (Weinh) 2025, 12: e2414547.","journal-title":"Adv Sci (Weinh)"},{"key":"1564_CR145","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s13311-021-01150-2","volume":"18","author":"A Rawat","year":"2021","unstructured":"Rawat A, Morrison BM. Metabolic transporters in the peripheral nerve-what, where, and why? Neurotherapeutics 2021, 18: 2185\u20132199.","journal-title":"Neurotherapeutics"},{"key":"1564_CR146","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1016\/j.devcel.2021.09.013","volume":"56","author":"L Jia","year":"2021","unstructured":"Jia L, Liao M, Mou A, Zheng Q, Yang W, Yu Z, et al. Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability. Dev Cell 2021, 56: 2980-2994.e6.","journal-title":"Dev Cell"},{"key":"1564_CR147","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/s41593-025-01954-x","volume":"28","author":"LJ Donovan","year":"2025","unstructured":"Donovan LJ, Brewer CL, Bond SF, Laslavic AM, Pena Lopez A, Colman L, et al. Aging and injury drive neuronal senescence in the dorsal root Ganglia. Nat Neurosci 2025, 28: 985\u2013997.","journal-title":"Nat Neurosci"},{"key":"1564_CR148","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102690","volume":"105","author":"S Haider","year":"2025","unstructured":"Haider S, Sassu E, Stefanovska D, Stoyek MR, Preissl S, Hortells L. News from the old: Aging features in the intracardiac, musculoskeletal, and enteric nervous systems. Ageing Res Rev 2025, 105: 102690.","journal-title":"Ageing Res Rev"},{"key":"1564_CR149","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s43587-021-00049-z","volume":"1","author":"J Groh","year":"2021","unstructured":"Groh J, Kn\u00f6pper K, Arampatzi P, Yuan X, L\u00f6\u00dflein L, Saliba AE, et al. Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Nat Aging 2021, 1: 357\u2013367.","journal-title":"Nat Aging"},{"key":"1564_CR150","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fnagi.2020.00174","volume":"12","author":"JA Stratton","year":"2020","unstructured":"Stratton JA, Eaton S, Rosin NL, Jawad S, Holmes A, Yoon G, et al. Macrophages and associated ligands in the aged injured nerve: A defective dynamic that contributes to reduced axonal regrowth. Front Aging Neurosci 2020, 12: 174.","journal-title":"Front Aging Neurosci"},{"key":"1564_CR151","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","volume":"15","author":"M Locati","year":"2020","unstructured":"Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol 2020, 15: 123\u2013147.","journal-title":"Annu Rev Pathol"},{"key":"1564_CR152","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.pneurobio.2018.12.001","volume":"173","author":"RE Zigmond","year":"2019","unstructured":"Zigmond RE, Echevarria FD. Macrophage biology in the peripheral nervous system after injury. Prog Neurobiol 2019, 173: 102\u2013121.","journal-title":"Prog Neurobiol"},{"key":"1564_CR153","doi-asserted-by":"publisher","first-page":"6208","DOI":"10.4049\/jimmunol.1102188","volume":"187","author":"CN Lumeng","year":"2011","unstructured":"Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, et al. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol 2011, 187: 6208\u20136216.","journal-title":"J Immunol"},{"key":"1564_CR154","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120767","volume":"272","author":"X Dong","year":"2021","unstructured":"Dong X, Liu S, Yang Y, Gao S, Li W, Cao J, et al. Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration. Biomaterials 2021, 272: 120767.","journal-title":"Biomaterials"},{"key":"1564_CR155","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/s41401-021-00736-y","volume":"43","author":"D Li","year":"2022","unstructured":"Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, et al. Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3. Acta Pharmacol Sin 2022, 43: 1285\u20131298.","journal-title":"Acta Pharmacol Sin"},{"key":"1564_CR156","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302660","volume":"13","author":"H Jin","year":"2024","unstructured":"Jin H, Kang Y, Gao H, Lin Z, Huang D, Zheng Z, et al. Decellularization-based modification strategy for bioactive xenografts promoting tendon repair. Adv Healthc Mater 2024, 13: e2302660.","journal-title":"Adv Healthc Mater"},{"key":"1564_CR157","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: Signaling pathways and intervention therapies. Signal Transduct Target Ther 2023, 8: 239.","journal-title":"Signal Transduct Target Ther"},{"issue":"Pt 1","key":"1564_CR158","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.expneurol.2015.09.018","volume":"275","author":"JP Niemi","year":"2016","unstructured":"Niemi JP, DeFrancesco-Lisowitz A, Cregg JM, Howarth M, Zigmond RE. Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism. Exp Neurol 2016, 275(Pt 1): 25\u201337.","journal-title":"Exp Neurol"},{"key":"1564_CR159","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113753","volume":"43","author":"Y Huang","year":"2024","unstructured":"Huang Y, Wu L, Zhao Y, Guo J, Li R, Ma S, et al. Schwann cell promotes macrophage recruitment through IL-17B\/IL-17RB pathway in injured peripheral nerves. Cell Rep 2024, 43: 113753.","journal-title":"Cell Rep"},{"key":"1564_CR160","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.actbio.2025.02.060","volume":"197","author":"K Li","year":"2025","unstructured":"Li K, Lin H, Yu Y, Liu Y, Yang W, Chen S, et al. Nucleus pulposus cell-mimicking nanoparticles for cell-specific HIF1A editing to modulate SASP-mediated disc inflammation via autophagy activation. Acta Biomater 2025, 197: 357\u2013373.","journal-title":"Acta Biomater"},{"key":"1564_CR161","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1093\/brain\/awv289","volume":"138","author":"MS Natrajan","year":"2015","unstructured":"Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nu\u00f1ez V, Johnson KR, et al. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain 2015, 138: 3581\u20133597.","journal-title":"Brain"},{"key":"1564_CR162","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12951-023-01767-9","volume":"21","author":"J Huang","year":"2023","unstructured":"Huang J, Zhang G, Li S, Li J, Wang W, Xue J, et al. Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration. J Nanobiotechnology 2023, 21: 10.","journal-title":"J Nanobiotechnology"},{"key":"1564_CR163","doi-asserted-by":"crossref","unstructured":"Zhou L, Kong G, Palmisano I, Cencioni MT, Danzi M, De Virgiliis F, et al. Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline. Science 2022, 376: eabd5926.","DOI":"10.1126\/science.abd5926"},{"key":"1564_CR164","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0006-8993(00)03038-9","volume":"888","author":"KE Hall","year":"2001","unstructured":"Hall KE, Sheng HC, Srinivasan S, Spitsbergen JM, Tuttle JB, Steers WD, et al. Treatment of aged rat sensory neurons in short-term, serum-free culture with nerve growth factor reverses the effect of aging on neurite outgrowth, calcium currents, and neuronal survival. Brain Res 2001, 888: 128\u2013137.","journal-title":"Brain Res"},{"key":"1564_CR165","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/dneu.20934","volume":"71","author":"DL Moore","year":"2011","unstructured":"Moore DL, Goldberg JL. Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol 2011, 71: 1186\u20131211.","journal-title":"Dev Neurobiol"},{"key":"1564_CR166","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.nbd.2019.02.001","volume":"127","author":"JE Shin","year":"2019","unstructured":"Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A. DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury. Neurobiol Dis 2019, 127: 178\u2013192.","journal-title":"Neurobiol Dis"},{"key":"1564_CR167","doi-asserted-by":"publisher","first-page":"E9899","DOI":"10.1073\/pnas.1805351115","volume":"115","author":"S Karney-Grobe","year":"2018","unstructured":"Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A. HSP90 is a chaperone for DLK and is required for axon injury signaling. Proc Natl Acad Sci USA 2018, 115: E9899\u2013E9908.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1564_CR168","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113801","volume":"43","author":"E Asghari Adib","year":"2024","unstructured":"Asghari Adib E, Shadrach JL, Reilly-Jankowiak L, Dwivedi MK, Rogers AE, Shahzad S, et al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep 2024, 43: 113801.","journal-title":"Cell Rep"},{"key":"1564_CR169","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33910","volume":"7","author":"JJ Wlaschin","year":"2018","unstructured":"Wlaschin JJ, Gluski JM, Nguyen E, Silberberg H, Thompson JH, Chesler AT, et al. Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury. Elife 2018, 7: e33910.","journal-title":"Elife"},{"key":"1564_CR170","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2004.06.005","volume":"43","author":"G Raivich","year":"2004","unstructured":"Raivich G, Bohatschek M, Da Costa C, Iwata O, Galiano M, Hristova M, et al. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 2004, 43: 57\u201367.","journal-title":"Neuron"},{"key":"1564_CR171","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1006\/exnr.1997.6665","volume":"148","author":"E Broude","year":"1997","unstructured":"Broude E, McAtee M, Kelley MS, Bregman BS. C-Jun expression in adult rat dorsal root ganglion neurons: Differential response after central or peripheral axotomy. Exp Neurol 1997, 148: 367\u2013377.","journal-title":"Exp Neurol"},{"key":"1564_CR172","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.3390\/biomedicines10123186","volume":"10","author":"R Akram","year":"2022","unstructured":"Akram R, Anwar H, Javed MS, Rasul A, Imran A, Malik SA, et al. Axonal regeneration: Underlying molecular mechanisms and potential therapeutic targets. Biomedicines 2022, 10: 3186.","journal-title":"Biomedicines"},{"key":"1564_CR173","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12031-017-0885-1","volume":"61","author":"H Wu","year":"2017","unstructured":"Wu H, Zhao J, Chen M, Wang H, Yao Q, Fan J, et al. The anti-aging effect of erythropoietin via the ERK\/Nrf2-ARE pathway in aging rats. J Mol Neurosci 2017, 61: 449\u2013458.","journal-title":"J Mol Neurosci"},{"key":"1564_CR174","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1179\/174313209X380883","volume":"31","author":"S Agthong","year":"2009","unstructured":"Agthong S, Koonam J, Kaewsema A, Chentanez V. Inhibition of MAPK ERK impairs axonal regeneration without an effect on neuronal loss after nerve injury. Neurol Res 2009, 31: 1068\u20131074.","journal-title":"Neurol Res"},{"key":"1564_CR175","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.celrep.2016.03.029","volume":"15","author":"X Luo","year":"2016","unstructured":"Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, et al. Enhanced transcriptional activity and mitochondrial localization of STAT3 co-induce axon regrowth in the adult central nervous system. Cell Rep 2016, 15: 398\u2013410.","journal-title":"Cell Rep"},{"key":"1564_CR176","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107657","volume":"31","author":"Z Hu","year":"2020","unstructured":"Hu Z, Deng N, Liu K, Zhou N, Sun Y, Zeng W. CNTF-STAT3-IL-6 axis mediates neuroinflammatory cascade across schwann cell-neuron-microglia. Cell Rep 2020, 31: 107657.","journal-title":"Cell Rep"},{"key":"1564_CR177","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13773","volume":"22","author":"A Sarkar","year":"2023","unstructured":"Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, et al. STAT3 promotes a youthful epigenetic state in articular chondrocytes. Aging Cell 2023, 22: e13773.","journal-title":"Aging Cell"},{"key":"1564_CR178","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1083\/jcb.201203109","volume":"199","author":"BT Selvaraj","year":"2012","unstructured":"Selvaraj BT, Frank N, Bender FLP, Asan E, Sendtner M. Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J Cell Biol 2012, 199: 437\u2013451.","journal-title":"J Cell Biol"},{"key":"1564_CR179","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/s43587-023-00486-y","volume":"3","author":"Y Ye","year":"2023","unstructured":"Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, et al. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nat Aging 2023, 3: 1269\u20131287.","journal-title":"Nat Aging"},{"key":"1564_CR180","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13996","volume":"22","author":"E Zukowski","year":"2023","unstructured":"Zukowski E, Sannella M, Rockhold JD, Kalantar GH, Yu J, SantaCruz-Calvo S, et al. STAT3 modulates CD4+ T mitochondrial dynamics and function in aging. Aging Cell 2023, 22: e13996.","journal-title":"Aging Cell"},{"key":"1564_CR181","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00011-021-01498-3","volume":"70","author":"A Salminen","year":"2021","unstructured":"Salminen A, Kaarniranta K, Kauppinen A. Insulin\/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: Impact on the aging process and age-related diseases. Inflamm Res 2021, 70: 1043\u20131061.","journal-title":"Inflamm Res"},{"key":"1564_CR182","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neuron.2012.04.028","volume":"74","author":"JE Shin","year":"2012","unstructured":"Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron 2012, 74: 1015\u20131022.","journal-title":"Neuron"},{"key":"1564_CR183","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3390\/cells8080854","volume":"8","author":"F Perner","year":"2019","unstructured":"Perner F, Perner C, Ernst T, Heidel FH. Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation. Cells 2019, 8: 854.","journal-title":"Cells"},{"key":"1564_CR184","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/nm.3655","volume":"20","author":"FD Price","year":"2014","unstructured":"Price FD, von Maltzahn J, Bentzinger CF, Dumont NA, Yin H, Chang NC, et al. Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nat Med 2014, 20: 1174\u20131181.","journal-title":"Nat Med"},{"key":"1564_CR185","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.4103\/1673-5374.313049","volume":"16","author":"Y Wang","year":"2021","unstructured":"Wang Y, Kong XQ, Wu F, Xu B, Bao DJ, Cheng CD, et al. SOCS1\/JAK2\/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses. Neural Regen Res 2021, 16: 2453\u20132464.","journal-title":"Neural Regen Res"},{"key":"1564_CR186","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220686","volume":"220","author":"Q Sun","year":"2023","unstructured":"Sun Q, Zhao X, Li R, Liu D, Pan B, Xie B, et al. STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection. J Exp Med 2023, 220: e20220686.","journal-title":"J Exp Med"},{"key":"1564_CR187","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122041","volume":"332","author":"L Wang","year":"2023","unstructured":"Wang L, Tu W, Li X, Li C, Lu J, Dai P, et al. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ\/STAT3 in mice with stroke. Life Sci 2023, 332: 122041.","journal-title":"Life Sci"},{"key":"1564_CR188","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.joca.2021.01.008","volume":"29","author":"R Wiegertjes","year":"2021","unstructured":"Wiegertjes R, Thielen NM, van Caam AM, van Laar M, van Beuningen HM, Koenders MI, et al. Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-\u03b2-mediated IL-6 receptor suppression. Osteoarthritis Cartilage 2021, 29: 773\u2013782.","journal-title":"Osteoarthritis Cartilage"},{"key":"1564_CR189","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101838","volume":"5","author":"M Shi","year":"2024","unstructured":"Shi M, Yang Y, Huang N, Zeng D, Mo Z, Wang J, et al. Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy. Cell Rep Med 2024, 5: 101838.","journal-title":"Cell Rep Med"},{"key":"1564_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114496","volume":"43","author":"K Etoh","year":"2024","unstructured":"Etoh K, Araki H, Koga T, Hino Y, Kuribayashi K, Hino S, et al. Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers. Cell Rep 2024, 43: 114496.","journal-title":"Cell Rep"},{"key":"1564_CR191","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.neuron.2020.06.015","volume":"107","author":"X Liu","year":"2020","unstructured":"Liu X, Beaudoin JD, Davison CA, Kosmaczewski SG, Meyer BI, Giraldez AJ, et al. A functional non-coding RNA is produced from xbp-1 mRNA. Neuron 2020, 107: 854-863.e6.","journal-title":"Neuron"},{"key":"1564_CR192","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111952","volume":"41","author":"F Cabral-Miranda","year":"2022","unstructured":"Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, et al. Unfolded protein response IRE1\/XBP1 signaling is required for healthy mammalian brain aging. EMBO J 2022, 41: e111952.","journal-title":"EMBO J"},{"key":"1564_CR193","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1002\/ptr.8502","volume":"39","author":"Y Du","year":"2025","unstructured":"Du Y, Bai J, Ma T, Wu Z, Wang P, Zhong X, et al. Sinomenine ameliorates liver fibrosis by blocking TGF-\u03b2\/SMAD and c-JUN signaling. Phytother Res 2025, 39: 3182\u20133196.","journal-title":"Phytother Res"},{"key":"1564_CR194","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121331","volume":"315","author":"B Zhu","year":"2023","unstructured":"Zhu B, Ni Y, Gong Y, Kang X, Guo H, Liu X, et al. Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3\/ATF3\/SLC7A11 signaling. Life Sci 2023, 315: 121331.","journal-title":"Life Sci"},{"key":"1564_CR195","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108777","volume":"34","author":"JA Lindborg","year":"2021","unstructured":"Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, et al. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep 2021, 34: 108777.","journal-title":"Cell Rep"},{"key":"1564_CR196","doi-asserted-by":"publisher","first-page":"33597","DOI":"10.1073\/pnas.2004683117","volume":"117","author":"AK Patel","year":"2020","unstructured":"Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, Torre AL, et al. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A 2020, 117: 33597\u201333607.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR197","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3390\/biomedicines12061256","volume":"12","author":"D Gu","year":"2024","unstructured":"Gu D, Xia Y, Ding Z, Qian J, Gu X, Bai H, et al. Inflammation in the peripheral nervous system after injury. Biomedicines 2024, 12: 1256.","journal-title":"Biomedicines"},{"key":"1564_CR198","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.3390\/ijms20122904","volume":"20","author":"L Brandolini","year":"2019","unstructured":"Brandolini L, D\u2019Angelo M, Antonosante A, Allegretti M, Cimini A. Chemokine signaling in chemotherapy-induced neuropathic pain. Int J Mol Sci 2019, 20: 2904.","journal-title":"Int J Mol Sci"},{"key":"1564_CR199","doi-asserted-by":"crossref","unstructured":"Shen Y, Yang P, Dai W, Gu X, Yi S. Transforming growth factor beta-related proteins promote axonal regeneration of injured dorsal root ganglion neurons. Neural Regen Res 2025.","DOI":"10.4103\/NRR.NRR-D-24-01427"},{"key":"1564_CR200","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85309","volume":"12","author":"D Wang","year":"2023","unstructured":"Wang D, Zheng T, Zhou S, Liu M, Liu Y, Gu X, et al. Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5. Elife 2023, 12: e85309.","journal-title":"Elife"},{"key":"1564_CR201","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s10456-024-09922-y","volume":"27","author":"TT Chang","year":"2024","unstructured":"Chang TT, Lin LY, Chen C, Chen JW. CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation. Angiogenesis 2024, 27: 475\u2013499.","journal-title":"Angiogenesis"},{"key":"1564_CR202","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016409118","volume":"118","author":"AM Hilla","year":"2021","unstructured":"Hilla AM, Baehr A, Leibinger M, Andreadaki A, Fischer D. CXCR4\/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration. Proc Natl Acad Sci U S A 2021, 118: e2016409118.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR203","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1038\/s41592-025-02697-0","volume":"22","author":"DC Jones","year":"2025","unstructured":"Jones DC, Elz AE, Hadadianpour A, Ryu H, Glass DR, Newell EW. Cell simulation as cell segmentation. Nat Methods 2025, 22: 1331\u20131342.","journal-title":"Nat Methods"},{"key":"1564_CR204","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202508095","volume":"12","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, Zhao W, Zhu Y, Liu H, Sun Y, Gong Z, et al. CXCL13 expression promotes CAR T cell antitumor activity and potentiates response to PD-1 blockade. Adv Sci (Weinh) 2025, 12: e08095.","journal-title":"Adv Sci (Weinh)"},{"key":"1564_CR205","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157215","volume":"7","author":"M Ukita","year":"2022","unstructured":"Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, et al. CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer. JCI Insight 2022, 7: e157215.","journal-title":"JCI Insight"},{"key":"1564_CR206","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163145","volume":"134","author":"XW Wang","year":"2023","unstructured":"Wang XW, Yang SG, Hu MW, Wang RY, Zhang C, Kosanam AR, et al. Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. J Clin Invest 2023, 134: e163145.","journal-title":"J Clin Invest"},{"key":"1564_CR207","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s40478-024-01917-6","volume":"12","author":"M Rao","year":"2024","unstructured":"Rao M, Luo Z, Liu CC, Chen CY, Wang S, Nahmou M, et al. Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration. Acta Neuropathol Commun 2024, 12: 204.","journal-title":"Acta Neuropathol Commun"},{"key":"1564_CR208","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41586-022-04884-x","volume":"607","author":"E Serger","year":"2022","unstructured":"Serger E, Luengo-Gutierrez L, Chadwick JS, Kong G, Zhou L, Crawford G, et al. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature 2022, 607: 585\u2013592.","journal-title":"Nature"},{"key":"1564_CR209","doi-asserted-by":"crossref","unstructured":"Bakooshli MA, Wang YX, Monti E, Su S, Kraft P, Nalbandian M, et al. Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase. Sci Transl Med 2023, 15: eadg1485.","DOI":"10.1126\/scitranslmed.adg1485"},{"key":"1564_CR210","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrneurol.2013.227","volume":"9","author":"J Scheib","year":"2013","unstructured":"Scheib J, H\u00f6ke A. Advances in peripheral nerve regeneration. Nat Rev Neurol 2013, 9: 668\u2013676.","journal-title":"Nat Rev Neurol"},{"key":"1564_CR211","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/biomedicines11041145","volume":"11","author":"MY Jin","year":"2023","unstructured":"Jin MY, Weaver TE, Farris A, Gupta M, Abd-Elsayed A. Neuromodulation for peripheral nerve regeneration: Systematic review of mechanisms and in vivo highlights. Biomedicines 2023, 11: 1145.","journal-title":"Biomedicines"},{"key":"1564_CR212","doi-asserted-by":"crossref","unstructured":"Fried K, Bongenhielm U, Boissonade FM, Robinson PP. Nerve injury-induced pain in the trigeminal system. Neuroscientist 2001, 7: 155\u2013165.","DOI":"10.1177\/107385840100700210"},{"key":"1564_CR213","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1146\/annurev-physiol-022516-034255","volume":"80","author":"L Li","year":"2018","unstructured":"Li L, Xiong WC, Mei L. Neuromuscular junction formation, aging, and disorders. Annu Rev Physiol 2018, 80: 159\u2013188.","journal-title":"Annu Rev Physiol"},{"key":"1564_CR214","doi-asserted-by":"crossref","unstructured":"Hastings RL, Avila MF, Suneby E, Juros D, O\u2019Young A, Peres da Silva J, et al. Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions. Aging Cell 2023, 22: e13981.","DOI":"10.1111\/acel.13981"},{"issue":"121","key":"1564_CR215","first-page":"982","volume":"2016","author":"SK Hunter","year":"1985","unstructured":"Hunter SK, Pereira HM, Keenan KG. The aging neuromuscular system and motor performance. J Appl Physiol 1985, 2016(121): 982\u2013995.","journal-title":"J Appl Physiol"},{"key":"1564_CR216","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101966","volume":"89","author":"W David Arnold","year":"2023","unstructured":"David Arnold W, Clark BC. Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems. Ageing Res Rev 2023, 89: 101966.","journal-title":"Ageing Res Rev"},{"key":"1564_CR217","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.4103\/1673-5374.390974","volume":"19","author":"B Richardson","year":"2024","unstructured":"Richardson B, Goedert T, Quraishe S, Deinhardt K, Mudher A. How do neurons age? A focused review on the aging of the microtubular cytoskeleton. Neural Regen Res 2024, 19: 1899\u20131907.","journal-title":"Neural Regen Res"},{"key":"1564_CR218","doi-asserted-by":"crossref","unstructured":"Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, et al. Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science 2021, 371: eabc8059.","DOI":"10.1126\/science.abc8059"},{"key":"1564_CR219","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","volume":"21","author":"GY Liu","year":"2020","unstructured":"Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol 2020, 21: 183\u2013203.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1564_CR220","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1038\/s41467-019-11227-4","volume":"10","author":"P Castets","year":"2019","unstructured":"Castets P, Rion N, Th\u00e9odore M, Falcetta D, Lin S, Reischl M, et al. mTORC1 and PKB\/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nat Commun 2019, 10: 3187.","journal-title":"Nat Commun"},{"key":"1564_CR221","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1172\/JCI72017","volume":"124","author":"S Kariya","year":"2014","unstructured":"Kariya S, Obis T, Garone C, Akay T, Sera F, Iwata S, et al. Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation. J Clin Invest 2014, 124: 785\u2013800.","journal-title":"J Clin Invest"},{"key":"1564_CR222","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/PRS.0000000000009999","volume":"151","author":"A Jablonka-Shariff","year":"2023","unstructured":"Jablonka-Shariff A, Balta E, Santosa KB, Lu CY, Snyder-Warwick AK. Terminal schwann cells are essential for neuromuscular junction function and recovery after nerve injury. Plast Reconstr Surg 2023, 151: 792\u2013803.","journal-title":"Plast Reconstr Surg"},{"key":"1564_CR223","doi-asserted-by":"publisher","first-page":"9602","DOI":"10.1523\/JNEUROSCI.1736-20.2020","volume":"40","author":"CY Lu","year":"2020","unstructured":"Lu CY, Santosa KB, Jablonka-Shariff A, Vannucci B, Fuchs A, Turnbull I, et al. Macrophage-derived vascular endothelial growth factor-a is integral to neuromuscular junction reinnervation after nerve injury. J Neurosci 2020, 40: 9602\u20139616.","journal-title":"J Neurosci"},{"key":"1564_CR224","doi-asserted-by":"publisher","first-page":"494","DOI":"10.14336\/AD.2020.0708","volume":"12","author":"S Fuertes-Alvarez","year":"2021","unstructured":"Fuertes-Alvarez S, Izeta A. Terminal schwann cell aging: Implications for age-associated neuromuscular dysfunction. Aging Dis 2021, 12: 494\u2013514.","journal-title":"Aging Dis"},{"key":"1564_CR225","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2021.103590","volume":"111","author":"R Rios","year":"2021","unstructured":"Rios R, Jablonka-Shariff A, Broberg C, Snyder-Warwick AK. Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery. Mol Cell Neurosci 2021, 111: 103590.","journal-title":"Mol Cell Neurosci"},{"key":"1564_CR226","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1093\/brain\/awae107","volume":"147","author":"M Traor\u00e9","year":"2024","unstructured":"Traor\u00e9 M, Noviello C, Vergnol A, Gentil C, Halliez M, Saillard L, et al. GDF5 as a rejuvenating treatment for age-related neuromuscular failure. Brain 2024, 147: 3834\u20133848.","journal-title":"Brain"},{"key":"1564_CR227","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41467-020-14930-9","volume":"11","author":"JH Kim","year":"2020","unstructured":"Kim JH, Kim I, Seol YJ, Ko IK, Yoo JJ, Atala A, et al. Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function. Nat Commun 2020, 11: 1025.","journal-title":"Nat Commun"},{"key":"1564_CR228","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3390\/biom11081256","volume":"11","author":"A Tinnirello","year":"2021","unstructured":"Tinnirello A, Mazzoleni S, Santi C. Chronic pain in the elderly: Mechanisms and distinctive features. Biomolecules 2021, 11: 1256.","journal-title":"Biomolecules"},{"key":"1564_CR229","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1124\/pr.117.014399","volume":"70","author":"SRA Alles","year":"2018","unstructured":"Alles SRA, Smith PA. Etiology and pharmacology of neuropathic pain. Pharmacol Rev 2018, 70: 315\u2013347.","journal-title":"Pharmacol Rev"},{"key":"1564_CR230","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s40520-020-01522-2","volume":"33","author":"RS Rech","year":"2021","unstructured":"Rech RS, Strotmeyer ES, Lange-Maia BS, Hugo FN, de Goulart BNG, Hilgert JB, et al. Swallowing impairment in older adults: Association with sensorimotor peripheral nerve function from the health, aging and body composition study. Aging Clin Exp Res 2021, 33: 165\u2013173.","journal-title":"Aging Clin Exp Res"},{"key":"1564_CR231","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154317","volume":"132","author":"M Defaye","year":"2022","unstructured":"Defaye M, Iftinca MC, Gadotti VM, Basso L, Abdullah NS, Cum\u00e9nal M, et al. The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain. J Clin Invest 2022, 132: e154317.","journal-title":"J Clin Invest"},{"key":"1564_CR232","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163735","volume":"133","author":"S He","year":"2023","unstructured":"He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, et al. A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. J Clin Invest 2023, 133: e163735.","journal-title":"J Clin Invest"},{"key":"1564_CR233","doi-asserted-by":"publisher","DOI":"10.1172\/JCI153563","volume":"132","author":"S Du","year":"2022","unstructured":"Du S, Wu S, Feng X, Wang B, Xia S, Liang L, et al. A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression. J Clin Invest 2022, 132: e153563.","journal-title":"J Clin Invest"},{"key":"1564_CR234","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S1474-4422(22)00188-0","volume":"21","author":"MA Elafros","year":"2022","unstructured":"Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, et al. Towards prevention of diabetic peripheral neuropathy: Clinical presentation, pathogenesis, and new treatments. Lancet Neurol 2022, 21: 922\u2013936.","journal-title":"Lancet Neurol"},{"key":"1564_CR235","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1164\/rccm.201002-0314OC","volume":"183","author":"CC dos Santos","year":"2011","unstructured":"dos Santos CC, Shan Y, Akram A, Slutsky AS, Haitsma JJ. Neuroimmune regulation of ventilator-induced lung injury. Am J Respir Crit Care Med 2011, 183: 471\u2013482.","journal-title":"Am J Respir Crit Care Med"},{"key":"1564_CR236","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143777","volume":"131","author":"M Hanscom","year":"2021","unstructured":"Hanscom M, Loane DJ, Shea-Donohue T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. J Clin Invest 2021, 131: e143777.","journal-title":"J Clin Invest"},{"key":"1564_CR237","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1126\/science.ade4961","volume":"381","author":"JUG Wagner","year":"2023","unstructured":"Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, et al. Aging impairs the neurovascular interface in the heart. Science 2023, 381: 897\u2013906.","journal-title":"Science"},{"key":"1564_CR238","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1016\/j.cell.2024.04.005","volume":"187","author":"X Liu","year":"2024","unstructured":"Liu X, Xin DE, Zhong X, Zhao C, Li Z, Zhang L, et al. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell 2024, 187: 2465-2484.e22.","journal-title":"Cell"},{"key":"1564_CR239","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","volume":"588","author":"Y Lu","year":"2020","unstructured":"Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 2020, 588: 124\u2013129.","journal-title":"Nature"},{"key":"1564_CR240","doi-asserted-by":"publisher","first-page":"31851","DOI":"10.1038\/srep31851","volume":"6","author":"G Hu","year":"2016","unstructured":"Hu G, Huang K, Hu Y, Du G, Xue Z, Zhu X, et al. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci Rep 2016, 6: 31851.","journal-title":"Sci Rep"},{"key":"1564_CR241","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","volume":"103","author":"JS Harrington","year":"2023","unstructured":"Harrington JS, Ryter SW, Plataki M, Price DR, Choi AMK. Mitochondria in health, disease, and aging. Physiol Rev 2023, 103: 2349\u20132422.","journal-title":"Physiol Rev"},{"key":"1564_CR242","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2012.08.019","volume":"75","author":"JJ Harris","year":"2012","unstructured":"Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron 2012, 75: 762\u2013777.","journal-title":"Neuron"},{"key":"1564_CR243","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.1201940","volume":"333","author":"DR Green","year":"2011","unstructured":"Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011, 333: 1109\u20131112.","journal-title":"Science"},{"key":"1564_CR244","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158447","volume":"132","author":"S Miwa","year":"2022","unstructured":"Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest 2022, 132: e158447.","journal-title":"J Clin Invest"},{"key":"1564_CR245","doi-asserted-by":"crossref","unstructured":"Ruan Y, Cheng J, Dai J, Ma Z, Luo S, Yan R, et al. Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS. Sci Adv 2023, 9: eadh0183.","DOI":"10.1126\/sciadv.adh0183"},{"key":"1564_CR246","doi-asserted-by":"publisher","first-page":"724","DOI":"10.15252\/embj.201592862","volume":"35","author":"C Correia-Melo","year":"2016","unstructured":"Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, et al. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J 2016, 35: 724\u2013742.","journal-title":"EMBO J"},{"key":"1564_CR247","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102480","volume":"101","author":"RJ Reiter","year":"2024","unstructured":"Reiter RJ, Sharma RN, Manucha W, Rosales-Corral S, Almieda Chuffa LG, Loh D, et al. Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment. Ageing Res Rev 2024, 101: 102480.","journal-title":"Ageing Res Rev"},{"key":"1564_CR248","first-page":"13","volume":"2024","author":"E Bej","year":"1945","unstructured":"Bej E, Cesare P, D\u2019Angelo M, Volpe AR, Castelli V. Neuronal cell rearrangement during aging: Antioxidant compounds as a potential therapeutic approach. Cells 1945, 2024: 13.","journal-title":"Cells"},{"key":"1564_CR249","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003728","volume":"10","author":"P Dalle Pezze","year":"2014","unstructured":"Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TBL, von Zglinicki T, et al. Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions. PLoS Comput Biol 2014, 10: e1003728.","journal-title":"PLoS Comput Biol"},{"key":"1564_CR250","doi-asserted-by":"publisher","first-page":"E3388","DOI":"10.1073\/pnas.1722452115","volume":"115","author":"S Rizza","year":"2018","unstructured":"Rizza S, Cardaci S, Montagna C, Di Giacomo G, De Zio D, Bordi M, et al. S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy. Proc Natl Acad Sci U S A 2018, 115: E3388\u2013E3397.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR251","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/jcp.20753","volume":"209","author":"YS Yoon","year":"2006","unstructured":"Yoon YS, Yoon DS, Lim IK, Yoon SH, Chung HY, Rojo M, et al. Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 2006, 209: 468\u2013480.","journal-title":"J Cell Physiol"},{"key":"1564_CR252","doi-asserted-by":"publisher","first-page":"22977","DOI":"10.1074\/jbc.M700679200","volume":"282","author":"S Lee","year":"2007","unstructured":"Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, et al. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 2007, 282: 22977\u201322983.","journal-title":"J Biol Chem"},{"key":"1564_CR253","first-page":"1287","volume":"8","author":"Z Palkov\u00e1","year":"2016","unstructured":"Palkov\u00e1 Z, V\u00e1chov\u00e1 L. Mitochondria in aging cell differentiation. Aging (Albany NY) 2016, 8: 1287\u20131288.","journal-title":"Mitochondria in aging cell differentiation. Aging (Albany NY)"},{"key":"1564_CR254","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","volume":"32","author":"AS Kulkarni","year":"2020","unstructured":"Kulkarni AS, Gubbi S, Barzilai N. Benefits of metformin in attenuating the hallmarks of aging. Cell Metab 2020, 32: 15\u201330.","journal-title":"Cell Metab"},{"key":"1564_CR255","doi-asserted-by":"publisher","first-page":"e00441","DOI":"10.1128\/MCB.00441-17","volume":"37","author":"A Bartolom\u00e9","year":"2017","unstructured":"Bartolom\u00e9 A, Garc\u00eda-Aguilar A, Asahara SI, Kido Y, Guill\u00e9n C, Pajvani UB, et al. MTORC1 regulates both general autophagy and mitophagy induction after oxidative phosphorylation uncoupling. Mol Cell Biol 2017, 37: e00441-e517.","journal-title":"Mol Cell Biol"},{"key":"1564_CR256","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1083\/jcb.201610113","volume":"216","author":"B Carroll","year":"2017","unstructured":"Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, et al. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. J Cell Biol 2017, 216: 1949\u20131957.","journal-title":"J Cell Biol"},{"key":"1564_CR257","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","volume":"195","author":"Y Ge","year":"2022","unstructured":"Ge Y, Zhou M, Chen C, Wu X, Wang X. Role of AMPK mediated pathways in autophagy and aging. Biochimie 2022, 195: 100\u2013113.","journal-title":"Biochimie"},{"key":"1564_CR258","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/gerona\/glac135","volume":"78","author":"P Kumar","year":"2023","unstructured":"Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, et al. Supplementing Glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: A randomized clinical trial. J Gerontol A Biol Sci Med Sci 2023, 78: 75\u201389.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1564_CR259","doi-asserted-by":"publisher","first-page":"10515","DOI":"10.1073\/pnas.1509879112","volume":"112","author":"Y Takihara","year":"2015","unstructured":"Takihara Y, Inatani M, Eto K, Inoue T, Kreymerman A, Miyake S, et al. In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS. Proc Natl Acad Sci U S A 2015, 112: 10515\u201310520.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR260","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175211","volume":"931","author":"J Lin","year":"2022","unstructured":"Lin J, Fang X, Liu F, Zhang Y, Li Y, Fang Z, et al. P2Y14 receptor in trigeminal ganglion contributes to neuropathic pain in mice. Eur J Pharmacol 2022, 931: 175211.","journal-title":"Eur J Pharmacol"},{"key":"1564_CR261","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.neuron.2016.10.060","volume":"92","author":"R Cartoni","year":"2016","unstructured":"Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, et al. The mammalian-specific protein Armcx1 regulates mitochondrial transport during axon regeneration. Neuron 2016, 92: 1294\u20131307.","journal-title":"Neuron"},{"key":"1564_CR262","doi-asserted-by":"publisher","first-page":"1268883","DOI":"10.3389\/fnins.2023.1268883","volume":"17","author":"D Lu","year":"2023","unstructured":"Lu D, Feng Y, Liu G, Yang Y, Ren Y, Chen Z, et al. Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders. Front Neurosci 2023, 17: 1268883.","journal-title":"Front Neurosci"},{"key":"1564_CR263","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101411","volume":"30","author":"J Gao","year":"2024","unstructured":"Gao J, Zhou Y, Xu G, Wei Z, Ding L, Zhang W, et al. Hybrid hydrogels containing gradients in gold nanoparticles for localized delivery of mesenchymal stem cells and enhanced nerve tissues remodeling in vivo. Mater Today Bio 2024, 30: 101411.","journal-title":"Mater Today Bio"},{"key":"1564_CR264","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00018-009-0138-8","volume":"67","author":"J Lapointe","year":"2010","unstructured":"Lapointe J, Hekimi S. When a theory of aging ages badly. Cell Mol Life Sci 2010, 67: 1\u20138.","journal-title":"Cell Mol Life Sci"},{"key":"1564_CR265","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","volume":"1859","author":"S Cadenas","year":"2018","unstructured":"Cadenas S. Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta Bioenerg 2018, 1859: 940\u2013950.","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"1564_CR266","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 2020, 21: 363\u2013383.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1564_CR267","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging. Arch Toxicol 2023, 97: 2499\u20132574.","journal-title":"Arch Toxicol"},{"key":"1564_CR268","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2022.02.004","volume":"181","author":"M Jaganjac","year":"2022","unstructured":"Jaganjac M, Milkovic L, Zarkovic N, Zarkovic K. Oxidative stress and regeneration. Free Radic Biol Med 2022, 181: 154\u2013165.","journal-title":"Free Radic Biol Med"},{"key":"1564_CR269","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.stem.2013.04.001","volume":"12","author":"H Morimoto","year":"2013","unstructured":"Morimoto H, Iwata K, Ogonuki N, Inoue K, Atsuo O, Kanatsu-Shinohara M, et al. ROS are required for mouse spermatogonial stem cell self-renewal. Cell Stem Cell 2013, 12: 774\u2013786.","journal-title":"Cell Stem Cell"},{"key":"1564_CR270","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","volume":"17","author":"MS Cooke","year":"2003","unstructured":"Cooke MS, Evans MD, Dizdaroglu M, Lunec J. Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J 2003, 17: 1195\u20131214.","journal-title":"FASEB J"},{"key":"1564_CR271","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mrrev.2003.11.001","volume":"567","author":"MD Evans","year":"2004","unstructured":"Evans MD, Dizdaroglu M, Cooke MS. Oxidative DNA damage and disease: Induction, repair and significance. Mutat Res 2004, 567: 1\u201361.","journal-title":"Mutat Res"},{"key":"1564_CR272","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s11658-023-00489-y","volume":"28","author":"J Riegger","year":"2023","unstructured":"Riegger J, Schoppa A, Ruths L, Haffner-Luntzer M, Ignatius A. Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: A narrative review. Cell Mol Biol Lett 2023, 28: 76.","journal-title":"Cell Mol Biol Lett"},{"key":"1564_CR273","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103686","volume":"84","author":"D Chen","year":"2025","unstructured":"Chen D, Guo Z, Yao L, Sun Y, Dian Y, Zhao D, et al. Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer. Redox Biol 2025, 84: 103686.","journal-title":"Redox Biol"},{"key":"1564_CR274","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.128160","volume":"427","author":"M Kuczak","year":"2022","unstructured":"Kuczak M, Musia\u0142 M, Malarz K, Rurka P, Zor\u0119bski E, Musio\u0142 R, et al. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions. J Hazard Mater 2022, 427: 128160.","journal-title":"J Hazard Mater"},{"key":"1564_CR275","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.cmet.2020.02.002","volume":"31","author":"Q Han","year":"2020","unstructured":"Han Q, Xie Y, Ordaz JD, Huh AJ, Huang N, Wu W, et al. Restoring cellular energetics promotes axonal regeneration and functional recovery after spinal cord injury. Cell Metab 2020, 31: 623-641.e8.","journal-title":"Cell Metab"},{"key":"1564_CR276","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1083\/jcb.201605101","volume":"214","author":"B Zhou","year":"2016","unstructured":"Zhou B, Yu P, Lin MY, Sun T, Chen Y, Sheng ZH. Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits. J Cell Biol 2016, 214: 103\u2013119.","journal-title":"J Cell Biol"},{"key":"1564_CR277","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3390\/cells10071625","volume":"10","author":"TC Sutherland","year":"2021","unstructured":"Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, Phillip West A, et al. Age-dependent decline in neuron growth potential and mitochondria functions in cortical neurons. Cells 2021, 10: 1625.","journal-title":"Cells"},{"key":"1564_CR278","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/bs.apcsb.2023.02.013","volume":"136","author":"P Sarkar","year":"2023","unstructured":"Sarkar P, Kumar A, Behera PS, Thirumurugan K. Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders. Adv Protein Chem Struct Biol 2023, 136: 415\u2013455.","journal-title":"Adv Protein Chem Struct Biol"},{"key":"1564_CR279","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13024-023-00634-3","volume":"18","author":"S Yang","year":"2023","unstructured":"Yang S, Park JH, Lu HC. Axonal energy metabolism, and the effects in aging and neurodegenerative diseases. Mol Neurodegener 2023, 18: 49.","journal-title":"Mol Neurodegener"},{"key":"1564_CR280","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","volume":"24","author":"SI Imai","year":"2014","unstructured":"Imai SI, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol 2014, 24: 464\u2013471.","journal-title":"Trends Cell Biol"},{"key":"1564_CR281","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155313","volume":"137","author":"X Chang","year":"2022","unstructured":"Chang X, Li Y, Cai C, Wu F, He J, Zhang Y, et al. Mitochondrial quality control mechanisms as molecular targets in diabetic heart. Metabolism 2022, 137: 155313.","journal-title":"Metabolism"},{"key":"1564_CR282","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2024.101122","volume":"73","author":"N Reich","year":"2024","unstructured":"Reich N, H\u00f6lscher C. Cholecystokinin (CCK): A neuromodulator with therapeutic potential in Alzheimer\u2019s and Parkinson\u2019s disease. Front Neuroendocrinol 2024, 73: 101122.","journal-title":"Front Neuroendocrinol"},{"key":"1564_CR283","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cmet.2020.04.015","volume":"32","author":"LP Bharath","year":"2020","unstructured":"Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, et al. Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation. Cell Metab 2020, 32: 44-55.e6.","journal-title":"Cell Metab"},{"key":"1564_CR284","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/s41467-024-45044-1","volume":"15","author":"JI Jim\u00e9nez-Loygorri","year":"2024","unstructured":"Jim\u00e9nez-Loygorri JI, Villarejo-Zori B, Viedma-Poyatos \u00c1, Zapata-Mu\u00f1oz J, Ben\u00edtez-Fern\u00e1ndez R, Frutos-Lis\u00f3n MD, et al. Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS\/STING inflammation during aging. Nat Commun 2024, 15: 830.","journal-title":"Nat Commun"},{"key":"1564_CR285","doi-asserted-by":"publisher","first-page":"4743885","DOI":"10.1155\/2023\/4743885","volume":"2023","author":"S Kibreab","year":"2023","unstructured":"Kibreab S, Wang Z, Zhu X, Ren Y, Jing Y, Li X, et al. Reciprocal REG \u03b3-Nrf2 regulation promotes long period ROS scavenging in oxidative stress-induced cell aging. Oxid Med Cell Longev 2023, 2023: 4743885.","journal-title":"Oxid Med Cell Longev"},{"key":"1564_CR286","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1007\/s12640-023-00647-2","volume":"41","author":"SV Mangrulkar","year":"2023","unstructured":"Mangrulkar SV, Wankhede NL, Kale MB, Upaganlawar AB, Taksande BG, Umekar MJ, et al. Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease. Neurotox Res 2023, 41: 708\u2013729.","journal-title":"Neurotox Res"},{"key":"1564_CR287","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41392-023-01378-8","volume":"8","author":"S Xie","year":"2023","unstructured":"Xie S, Xu SC, Deng W, Tang Q. Metabolic landscape in cardiac aging: Insights into molecular biology and therapeutic implications. Signal Transduct Target Ther 2023, 8: 114.","journal-title":"Signal Transduct Target Ther"},{"key":"1564_CR288","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112883","volume":"42","author":"DC Maddison","year":"2023","unstructured":"Maddison DC, Malik B, Amadio L, Bis-Brewer DM, Z\u00fcchner S, Peters OM, et al. COPI-regulated mitochondria-ER contact site formation maintains axonal integrity. Cell Rep 2023, 42: 112883.","journal-title":"Cell Rep"},{"key":"1564_CR289","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.1038\/s41467-024-50502-x","volume":"15","author":"M Liiv","year":"2024","unstructured":"Liiv M, Vaarmann A, Safiulina D, Choubey V, Gupta R, Kuum M, et al. ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nat Commun 2024, 15: 6143.","journal-title":"Nat Commun"},{"key":"1564_CR290","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13195-025-01793-9","volume":"17","author":"G Dematteis","year":"2025","unstructured":"Dematteis G, Gong C, Malecka J, Tonelli E, Genazzani A, Tapella L, et al. Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer\u2019s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance. Alzheimers Res Ther 2025, 17: 148.","journal-title":"Alzheimers Res Ther"},{"key":"1564_CR291","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1038\/s44319-024-00204-8","volume":"25","author":"M Kalarikkal","year":"2024","unstructured":"Kalarikkal M, Saikia R, Oliveira L, Bhorkar Y, Lonare A, Varshney P, et al. Nup358 restricts ER-mitochondria connectivity by modulating mTORC2\/Akt\/GSK3\u03b2 signalling. EMBO Rep 2024, 25: 4226\u20134251.","journal-title":"EMBO Rep"},{"key":"1564_CR292","doi-asserted-by":"publisher","first-page":"673","DOI":"10.4103\/1673-5374.320997","volume":"17","author":"J Liu","year":"2022","unstructured":"Liu J, Li L, Zou Y, Fu L, Ma X, Zhang H, et al. Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury. Neural Regen Res 2022, 17: 673\u2013681.","journal-title":"Neural Regen Res"},{"key":"1564_CR293","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.conb.2018.02.024","volume":"51","author":"O Blanquie","year":"2018","unstructured":"Blanquie O, Bradke F. Cytoskeleton dynamics in axon regeneration. Curr Opin Neurobiol 2018, 51: 60\u201369.","journal-title":"Curr Opin Neurobiol"},{"key":"1564_CR294","doi-asserted-by":"publisher","first-page":"1623181","DOI":"10.1155\/2022\/1623181","volume":"2022","author":"L Huang","year":"2022","unstructured":"Huang L, Peng Y, Tao X, Ding X, Li R, Jiang Y, et al. Microtubule organization is essential for maintaining cellular morphology and function. Oxid Med Cell Longev 2022, 2022: 1623181.","journal-title":"Oxid Med Cell Longev"},{"key":"1564_CR295","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.965382","volume":"10","author":"K Metzner","year":"2022","unstructured":"Metzner K, Darawsha O, Wang M, Gaur N, Cheng Y, R\u00f6diger A, et al. Age-dependent increase of cytoskeletal components in sensory axons in human skin. Front Cell Dev Biol 2022, 10: 965382.","journal-title":"Front Cell Dev Biol"},{"key":"1564_CR296","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41586-022-05241-8","volume":"611","author":"W Oosterheert","year":"2022","unstructured":"Oosterheert W, Klink BU, Belyy A, Pospich S, Raunser S. Structural basis of actin filament assembly and aging. Nature 2022, 611: 374\u2013379.","journal-title":"Nature"},{"key":"1564_CR297","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1749-6632.2010.05191.x","volume":"1197","author":"BM Doshi","year":"2010","unstructured":"Doshi BM, Hightower LE, Lee J. HSPB1, actin filament dynamics, and aging cells. Ann N Y Acad Sci 2010, 1197: 76\u201384.","journal-title":"Ann N Y Acad Sci"},{"key":"1564_CR298","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.1016\/j.neuron.2023.11.011","volume":"111","author":"NPB Au","year":"2023","unstructured":"Au NPB, Wu T, Chen X, Gao F, Li YTY, Tam WY, et al. Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair. Neuron 2023, 111: 3970-3987.e8.","journal-title":"Neuron"},{"key":"1564_CR299","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E. Tau in physiology and pathology. Nat Rev Neurosci 2016, 17: 5\u201321.","journal-title":"Nat Rev Neurosci"},{"key":"1564_CR300","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/ana.27149","volume":"97","author":"A Affaneh","year":"2025","unstructured":"Affaneh A, Linden AK, Tunc-Ozcan E, Tsai YH, Peng CY, Kessler JA. Inhibition of bone morphogenetic protein signaling prevents tau pathology in iPSC derived neurons and PS19 mice. Ann Neurol 2025, 97: 657\u2013672.","journal-title":"Ann Neurol"},{"issue":"25","key":"1564_CR301","first-page":"00442","volume":"S2090\u20131232","author":"L Lei","year":"2025","unstructured":"Lei L, Guo Q, Cheng Y, Gui Y, Li W, Zhao Y, et al. Age-dependent elevation of Nr4a1 attenuates PI3K\/AKT\/GSK3\u03b2 pathway and mediates tau hyperphosphorylation and cognitive impairments. J Adv Res 2025, S2090\u20131232(25): 00442\u201300444.","journal-title":"J Adv Res"},{"key":"1564_CR302","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106526","volume":"198","author":"G Canet","year":"2024","unstructured":"Canet G, Gratuze M, Zussy C, Bouali ML, Diaz SD, Rocaboy E, et al. Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer\u2019s disease pathologies in 3xTg-AD mice. Neurobiol Dis 2024, 198: 106526.","journal-title":"Neurobiol Dis"},{"key":"1564_CR303","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14477","volume":"21","author":"D Datta","year":"2025","unstructured":"Datta D, Arnsten AFT. The etiology and prevention of early-stage tau pathology in higher cortical circuits: Insights from aging Rhesus macaques. Alzheimers Dement 2025, 21: e14477.","journal-title":"Alzheimers Dement"},{"key":"1564_CR304","doi-asserted-by":"publisher","first-page":"782","DOI":"10.2174\/1570159X19666211201101020","volume":"20","author":"A Soliman","year":"2022","unstructured":"Soliman A, Bakota L, Brandt R. Microtubule-modulating agents in the fight against neurodegeneration: Will it ever work? Curr Neuropharmacol 2022, 20: 782\u2013798.","journal-title":"Curr Neuropharmacol"},{"key":"1564_CR305","doi-asserted-by":"publisher","first-page":"14765","DOI":"10.1074\/jbc.M114.622753","volume":"290","author":"W Song","year":"2015","unstructured":"Song W, Cho Y, Watt D, Cavalli V. Tubulin-tyrosine ligase (TTL)-mediated increase in tyrosinated \u03b1-tubulin in injured axons is required for retrograde injury signaling and axon regeneration. J Biol Chem 2015, 290: 14765\u201314775.","journal-title":"J Biol Chem"},{"key":"1564_CR306","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101021","volume":"58","author":"WF Lai","year":"2020","unstructured":"Lai WF, Wong WT. Roles of the actin cytoskeleton in aging and age-associated diseases. Ageing Res Rev 2020, 58: 101021.","journal-title":"Ageing Res Rev"},{"key":"1564_CR307","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0531-5565(93)90032-9","volume":"28","author":"JA Moshier","year":"1993","unstructured":"Moshier JA, Cornell T, Majumdar AP. Expression of protease genes in the gastric mucosa during aging. Exp Gerontol 1993, 28: 249\u2013258.","journal-title":"Exp Gerontol"},{"key":"1564_CR308","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mad.2018.01.001","volume":"169","author":"J Zhou","year":"2018","unstructured":"Zhou J, Liao Z, Chen J, Zhao K, Xiao Q. Integrated study on comparative transcriptome and skeletal muscle function in aged rats. Mech Ageing Dev 2018, 169: 32\u201339.","journal-title":"Mech Ageing Dev"},{"key":"1564_CR309","doi-asserted-by":"publisher","first-page":"9238","DOI":"10.1038\/s41467-024-53389-w","volume":"15","author":"ET Schmid","year":"2024","unstructured":"Schmid ET, Schinaman JM, Liu-Abramowicz N, Williams KS, Walker DW. Accumulation of F-actin drives brain aging and limits healthspan in Drosophila. Nat Commun 2024, 15: 9238.","journal-title":"Nat Commun"},{"key":"1564_CR310","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11357-019-00133-8","volume":"42","author":"CM Toedebusch","year":"2020","unstructured":"Toedebusch CM, Garcia VB, Snyder JC, Jones MR, Schulz DJ, Johnson GC, et al. Lumbar spinal cord microglia exhibited increased activation in aging dogs compared with young adult dogs. Geroscience 2020, 42: 169\u2013182.","journal-title":"Geroscience"},{"key":"1564_CR311","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13742","volume":"22","author":"G Garcia","year":"2023","unstructured":"Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, et al. Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Aging Cell 2023, 22: e13742.","journal-title":"Aging Cell"},{"key":"1564_CR312","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1128\/MCB.00811-15","volume":"35","author":"P Vasicova","year":"2015","unstructured":"Vasicova P, Lejskova R, Malcova I, Hasek J. The stationary-phase cells of Saccharomyces cerevisiae display dynamic actin filaments required for processes extending chronological life span. Mol Cell Biol 2015, 35: 3892\u20133908.","journal-title":"Mol Cell Biol"},{"issue":"Suppl 1","key":"1564_CR313","doi-asserted-by":"publisher","first-page":"e088101","DOI":"10.1002\/alz.088101","volume":"20","author":"PA Haseena","year":"2024","unstructured":"Haseena PA, Kommaddi RP. Basic Science and Pathogenesis. Alzheimer\u2019s & dementia\u202f: the journal of the Alzheimer\u2019s Association 2024, 20(Suppl 1): e088101\u2013e088101. https:\/\/doi.org\/10.1002\/alz.088101.","journal-title":"Alzheimer's & dementia : the journal of the Alzheimer's Association"},{"key":"1564_CR314","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115680","volume":"214","author":"C Dahlstroem","year":"2023","unstructured":"Dahlstroem C, Paraschiakos T, Sun H, Windhorst S. Cryo-EM structures of actin binding proteins as tool for drug discovery. Biochem Pharmacol 2023, 214: 115680.","journal-title":"Biochem Pharmacol"},{"key":"1564_CR315","doi-asserted-by":"crossref","unstructured":"Ding EA, Kumar S. Neurofilament biophysics: From structure to biomechanics. Mol Biol Cell 2024, 35: re1.","DOI":"10.1091\/mbc.E23-11-0438"},{"key":"1564_CR316","doi-asserted-by":"crossref","unstructured":"Boyer NP, Julien JP, Jung P, Brown A. Neurofilament transport is bidirectional in vivo. eNeuro 2022, 9: ENEURO.0138\u201322.2022.","DOI":"10.1523\/ENEURO.0138-22.2022"},{"key":"1564_CR317","doi-asserted-by":"crossref","unstructured":"Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments and neurofilament proteins in health and disease. Cold Spring Harb Perspect Biol 2017, 9: a018309.","DOI":"10.1101\/cshperspect.a018309"},{"key":"1564_CR318","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/acn3.51524","volume":"9","author":"C Harp","year":"2022","unstructured":"Harp C, Thanei GA, Jia X, Kuhle J, Leppert D, Schaedelin S, et al. Development of an age-adjusted model for blood neurofilament light chain. Ann Clin Transl Neurol 2022, 9: 444\u2013453.","journal-title":"Ann Clin Transl Neurol"},{"key":"1564_CR319","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12916-024-03418-8","volume":"22","author":"X Wang","year":"2024","unstructured":"Wang X, Shi Z, Qiu Y, Sun D, Zhou H. Peripheral GFAP and NfL as early biomarkers for dementia: Longitudinal insights from the UK Biobank. BMC Med 2024, 22: 192.","journal-title":"BMC Med"},{"key":"1564_CR320","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","volume":"14","author":"M Khalil","year":"2018","unstructured":"Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, et al. Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 2018, 14: 577\u2013589.","journal-title":"Nat Rev Neurol"},{"key":"1564_CR321","doi-asserted-by":"crossref","unstructured":"Devarakonda SS, Basha S, Pithakumar A, L B T, Mukunda DC, Rodrigues J, et al. Molecular mechanisms of neurofilament alterations and its application in assessing neurodegenerative disorders. Ageing Res Rev 2024, 102: 102566.","DOI":"10.1016\/j.arr.2024.102566"},{"key":"1564_CR322","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1093\/brain\/awae079","volume":"147","author":"AP Rebelo","year":"2024","unstructured":"Rebelo AP, Abad C, Dohrn MF, Li JJ, Tieu EK, Medina J, et al. SORD-deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights. Brain 2024, 147: 3131\u20133143.","journal-title":"Brain"},{"key":"1564_CR323","doi-asserted-by":"publisher","DOI":"10.1172\/JCI168554","volume":"133","author":"SH Berth","year":"2023","unstructured":"Berth SH, Lloyd TE. Disruption of axonal transport in neurodegeneration. J Clin Invest 2023, 133: e168554.","journal-title":"J Clin Invest"},{"key":"1564_CR324","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105930","volume":"120","author":"B Fazeli","year":"2025","unstructured":"Fazeli B, Botzenhardt S, Bachhuber F, Klassen P, Klose V, Dorst J, et al. Comparative analysis of cerebrospinal fluid neurofilament medium, light and heavy chain in neurodegenerative diseases using an in-house assay for the detection of neurofilament medium chain. EBioMedicine 2025, 120: 105930.","journal-title":"EBioMedicine"},{"key":"1564_CR325","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/dneu.22748","volume":"81","author":"XT Cheng","year":"2021","unstructured":"Cheng XT, Sheng ZH. Developmental regulation of microtubule-based trafficking and anchoring of axonal mitochondria in health and diseases. Dev Neurobiol 2021, 81: 284\u2013299.","journal-title":"Dev Neurobiol"},{"key":"1564_CR326","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111324","volume":"40","author":"H Quintero","year":"2022","unstructured":"Quintero H, Shiga Y, Belforte N, Alarcon-Martinez L, El Hajji S, Villafranca-Baughman D, et al. Restoration of mitochondria axonal transport by adaptor Disc1 supplementation prevents neurodegeneration and rescues visual function. Cell Rep 2022, 40: 111324.","journal-title":"Cell Rep"},{"key":"1564_CR327","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1093\/brain\/awae183","volume":"148","author":"B M\u00f6ller","year":"2025","unstructured":"M\u00f6ller B, Becker LL, Saffari A, Afenjar A, Coci EG, Williamson R, et al. The expanding clinical and genetic spectrum of DYNC1H1-related disorders. Brain 2025, 148: 597\u2013612.","journal-title":"Brain"},{"key":"1564_CR328","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103383118","volume":"118","author":"P Sanghavi","year":"2021","unstructured":"Sanghavi P, Kumar P, Roy A, Madhusudhan MS, Mallik R. On and off controls within dynein-dynactin on native cargoes. Proc Natl Acad Sci U S A 2021, 118: e2103383118.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1564_CR329","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1016\/j.ajpath.2016.03.006","volume":"186","author":"N Kimura","year":"2016","unstructured":"Kimura N, Samura E, Suzuki K, Okabayashi S, Shimozawa N, Yasutomi Y. Dynein dysfunction reproduces age-dependent retromer deficiency: Concomitant disruption of retrograde trafficking is required for alteration in \u03b2-amyloid precursor protein metabolism. Am J Pathol 2016, 186: 1952\u20131966.","journal-title":"Am J Pathol"},{"key":"1564_CR330","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.ajpath.2011.10.037","volume":"180","author":"N Kimura","year":"2012","unstructured":"Kimura N, Okabayashi S, Ono F. Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function. Am J Pathol 2012, 180: 550\u2013561.","journal-title":"Am J Pathol"},{"key":"1564_CR331","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1002\/jnr.21408","volume":"85","author":"N Kimura","year":"2007","unstructured":"Kimura N, Imamura O, Ono F, Terao K. Aging attenuates dynactin-dynein interaction: Down-regulation of dynein causes accumulation of endogenous tau and amyloid precursor protein in human neuroblastoma cells. J Neurosci Res 2007, 85: 2909\u20132916.","journal-title":"J Neurosci Res"},{"key":"1564_CR332","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.nbd.2013.05.015","volume":"58","author":"J Eschbach","year":"2013","unstructured":"Eschbach J, Sinniger J, Bouitbir J, Fergani A, Schlagowski AI, Zoll J, et al. Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age. Neurobiol Dis 2013, 58: 220\u2013230.","journal-title":"Neurobiol Dis"},{"key":"1564_CR333","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199062","volume":"13","author":"LA Phung","year":"2018","unstructured":"Phung LA, Karvinen SM, Colson BA, Thomas DD, Lowe DA. Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice. PLoS One 2018, 13: e0199062.","journal-title":"PLoS One"},{"key":"1564_CR334","first-page":"0158","volume":"6","author":"HK So","year":"2023","unstructured":"So HK, Kim H, Lee J, You CL, Yun CE, Jeong HJ, et al. Protein arginine methyltransferase 1 ablation in motor neurons causes mitochondrial dysfunction leading to age-related motor neuron degeneration with muscle loss. Research (Wash D C) 2023, 6: 0158.","journal-title":"Research (Wash D C)"},{"key":"1564_CR335","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1007\/s11357-023-00772-y","volume":"45","author":"MJ Miller","year":"2023","unstructured":"Miller MJ, Marcotte GR, Basisty N, Wehrfritz C, Ryan ZC, Strub MD, et al. The transcription regulator ATF4 is a mediator of skeletal muscle aging. Geroscience 2023, 45: 2525\u20132543.","journal-title":"Geroscience"},{"key":"1564_CR336","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12974-022-02427-9","volume":"19","author":"K Moln\u00e1r","year":"2022","unstructured":"Moln\u00e1r K, N\u00f3gr\u00e1di B, Krist\u00f3f R, M\u00e9sz\u00e1ros \u00c1, Pajer K, Sikl\u00f3s L, et al. Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury. J Neuroinflammation 2022, 19: 68.","journal-title":"J Neuroinflammation"},{"key":"1564_CR337","doi-asserted-by":"publisher","first-page":"4610","DOI":"10.1523\/JNEUROSCI.3030-17.2018","volume":"38","author":"X Yuan","year":"2018","unstructured":"Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, et al. Macrophage depletion ameliorates peripheral neuropathy in aging mice. J Neurosci 2018, 38: 4610\u20134620.","journal-title":"J Neurosci"},{"key":"1564_CR338","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1097\/j.pain.0000000000002807","volume":"164","author":"V Borgonetti","year":"2023","unstructured":"Borgonetti V, Galeotti N. Microglia senescence is related to neuropathic pain-associated comorbidities in the spared nerve injury model. Pain 2023, 164: 1106\u20131117.","journal-title":"Pain"},{"key":"1564_CR339","doi-asserted-by":"publisher","first-page":"9076485","DOI":"10.1155\/2018\/9076485","volume":"2018","author":"F Olivieri","year":"2018","unstructured":"Olivieri F, Prattichizzo F, Grillari J, Balistreri CR. Cellular senescence and inflammaging in age-related diseases. Mediators Inflamm 2018, 2018: 9076485.","journal-title":"Mediators Inflamm"},{"key":"1564_CR340","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810248","volume":"11","author":"S Voet","year":"2019","unstructured":"Voet S, Srinivasan S, Lamkanfi M, van Loo G. Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO Mol Med 2019, 11: e10248.","journal-title":"EMBO Mol Med"},{"key":"1564_CR341","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41419-017-0153-x","volume":"9","author":"C Ising","year":"2018","unstructured":"Ising C, Heneka MT. Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration. Cell Death Dis 2018, 9: 120.","journal-title":"Cell Death Dis"},{"key":"1564_CR342","doi-asserted-by":"crossref","unstructured":"Trigo D, Nadais A, da Cruz E Silva OAB. Unravelling protein aggregation as an ageing related process or a neuropathological response. Ageing Res Rev 2019, 51: 67\u201377.","DOI":"10.1016\/j.arr.2019.02.001"},{"key":"1564_CR343","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/jnc.14674","volume":"149","author":"MR Nichols","year":"2019","unstructured":"Nichols MR, St-Pierre MK, Wendeln AC, Makoni NJ, Gouwens LK, Garrad EC, et al. Inflammatory mechanisms in neurodegeneration. J Neurochem 2019, 149: 562\u2013581.","journal-title":"J Neurochem"},{"key":"1564_CR344","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/j.neuron.2023.04.006","volume":"111","author":"BP Festa","year":"2023","unstructured":"Festa BP, Siddiqi FH, Jimenez-Sanchez M, Won H, Rob M, Djajadikerta A, et al. Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration. Neuron 2023, 111: 2021-2037.e12.","journal-title":"Neuron"},{"key":"1564_CR345","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.tcb.2021.06.010","volume":"31","author":"A Pandey","year":"2021","unstructured":"Pandey A, Shen C, Feng S, Man SM. Cell biology of inflammasome activation. Trends Cell Biol 2021, 31: 924\u2013939.","journal-title":"Trends Cell Biol"},{"key":"1564_CR346","doi-asserted-by":"publisher","first-page":"15359","DOI":"10.3390\/ijms242015359","volume":"24","author":"LI Benowitz","year":"2023","unstructured":"Benowitz LI, Xie L, Yin Y. Inflammatory mediators of axon regeneration in the central and peripheral nervous systems. Int J Mol Sci 2023, 24: 15359.","journal-title":"Int J Mol Sci"},{"key":"1564_CR347","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1093\/brain\/awv240","volume":"138","author":"D Klein","year":"2015","unstructured":"Klein D, Patzk\u00f3 \u00c1, Schreiber D, van Hauwermeiren A, Baier M, Groh J, et al. Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice. Brain 2015, 138: 3193\u20133205.","journal-title":"Brain"},{"key":"1564_CR348","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113063","volume":"260","author":"KJ Kim","year":"2020","unstructured":"Kim KJ, Hwang J, Park JY, Namgung U. Augmented Buyang Huanwu Decoction facilitates axonal regeneration after peripheral nerve transection through the regulation of inflammatory cytokine production. J Ethnopharmacol 2020, 260: 113063.","journal-title":"J Ethnopharmacol"},{"key":"1564_CR349","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41556-018-0039-x","volume":"20","author":"A Hervera","year":"2018","unstructured":"Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, et al. Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat Cell Biol 2018, 20: 307\u2013319.","journal-title":"Nat Cell Biol"},{"key":"1564_CR350","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1742-2094-8-110","volume":"8","author":"AD Gaudet","year":"2011","unstructured":"Gaudet AD, Popovich PG, Ramer MS. Wallerian degeneration: Gaining perspective on inflammatory events after peripheral nerve injury. J Neuroinflammation 2011, 8: 110.","journal-title":"J Neuroinflammation"},{"key":"1564_CR351","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3892\/ijmm.2017.2848","volume":"39","author":"G Yang","year":"2017","unstructured":"Yang G, Tang WY. Resistance of interleukin-6 to the extracellular inhibitory environment promotes axonal regeneration and functional recovery following spinal cord injury. Int J Mol Med 2017, 39: 437\u2013445.","journal-title":"Int J Mol Med"},{"key":"1564_CR352","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.immuni.2024.01.001","volume":"57","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Yao J, Wu D, Huang X, Wang Y, Li X, et al. Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging. Immunity 2024, 57: 513-527.e6.","journal-title":"Immunity"},{"key":"1564_CR353","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1021\/acs.nanolett.0c04713","volume":"21","author":"J Bian","year":"2021","unstructured":"Bian J, Cai F, Chen H, Tang Z, Xi K, Tang J, et al. Modulation of local overactive inflammation via injectable hydrogel microspheres. Nano Lett 2021, 21: 2690\u20132698.","journal-title":"Nano Lett"},{"key":"1564_CR354","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202201957","volume":"18","author":"Z Luo","year":"2022","unstructured":"Luo Z, Qi B, Sun Y, Chen Y, Lin J, Qin H, et al. Engineering bioactive M2 macrophage-polarized, anti-inflammatory, miRNA-based liposomes for functional muscle repair: From exosomal mechanisms to biomaterials. Small 2022, 18: e2201957.","journal-title":"Small"},{"key":"1564_CR355","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.7150\/thno.74571","volume":"12","author":"L Kong","year":"2022","unstructured":"Kong L, Gao X, Qian Y, Sun W, You Z, Fan C. Biomechanical microenvironment in peripheral nerve regeneration: From pathophysiological understanding to tissue engineering development. Theranostics 2022, 12: 4993\u20135014.","journal-title":"Theranostics"},{"key":"1564_CR356","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/dneu.22771","volume":"81","author":"RM Stassart","year":"2021","unstructured":"Stassart RM, Woodhoo A. Axo-glial interaction in the injured PNS. Dev Neurobiol 2021, 81: 490\u2013506.","journal-title":"Dev Neurobiol"},{"key":"1564_CR357","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1161\/CIRCRESAHA.123.323365","volume":"134","author":"M Faleeva","year":"2024","unstructured":"Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, et al. Sox9 accelerates vascular aging by regulating extracellular matrix composition and stiffness. Circ Res 2024, 134: 307\u2013324.","journal-title":"Circ Res"},{"key":"1564_CR358","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.arr.2017.07.004","volume":"40","author":"M Rahmati","year":"2017","unstructured":"Rahmati M, Nalesso G, Mobasheri A, Mozafari M. Aging and osteoarthritis: Central role of the extracellular matrix. Ageing Res Rev 2017, 40: 20\u201330.","journal-title":"Ageing Res Rev"},{"key":"1564_CR359","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12154","volume":"10","author":"Y Yin","year":"2021","unstructured":"Yin Y, Chen H, Wang Y, Zhang L, Wang X. Roles of extracellular vesicles in the aging microenvironment and age-related diseases. J Extracell Vesicles 2021, 10: e12154.","journal-title":"J Extracell Vesicles"},{"key":"1564_CR360","doi-asserted-by":"publisher","first-page":"5251","DOI":"10.1016\/j.biomaterials.2009.07.007","volume":"30","author":"VT Ribeiro-Resende","year":"2009","unstructured":"Ribeiro-Resende VT, Koenig B, Nichterwitz S, Oberhoffner S, Schlosshauer B. Strategies for inducing the formation of bands of B\u00fcngner in peripheral nerve regeneration. Biomaterials 2009, 30: 5251\u20135259.","journal-title":"Biomaterials"},{"key":"1564_CR361","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3390\/cells12060965","volume":"12","author":"A McGinnis","year":"2023","unstructured":"McGinnis A, Ji RR. The similar and distinct roles of satellite glial cells and spinal astrocytes in neuropathic pain. Cells 2023, 12: 965.","journal-title":"Cells"},{"key":"1564_CR362","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.1038\/s41467-020-18642-y","volume":"11","author":"O Avraham","year":"2020","unstructured":"Avraham O, Deng PY, Jones S, Kuruvilla R, Semenkovich CF, Klyachko VA, et al. Satellite glial cells promote regenerative growth in sensory neurons. Nat Commun 2020, 11: 4891.","journal-title":"Nat Commun"},{"key":"1564_CR363","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13948","volume":"22","author":"H Power","year":"2023","unstructured":"Power H, Valtchev P, Dehghani F, Schindeler A. Strategies for senolytic drug discovery. Aging Cell 2023, 22: e13948.","journal-title":"Aging Cell"},{"key":"1564_CR364","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1002\/glia.24581","volume":"72","author":"RI Brown","year":"2024","unstructured":"Brown RI, Barber HM, Kucenas S. Satellite glial cell manipulation prior to axotomy enhances developing dorsal root ganglion central branch regrowth into the spinal cord. Glia 2024, 72: 1766\u20131784.","journal-title":"Glia"},{"key":"1564_CR365","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41580-022-00562-y","volume":"24","author":"B Zheng","year":"2023","unstructured":"Zheng B, Tuszynski MH. Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol 2023, 24: 396\u2013413.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1564_CR366","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000599","volume":"18","author":"N Basisty","year":"2020","unstructured":"Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, et al. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol 2020, 18: e3000599.","journal-title":"PLoS Biol"},{"key":"1564_CR367","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41392-021-00765-3","volume":"6","author":"X Xiao","year":"2021","unstructured":"Xiao X, Xu M, Yu H, Wang L, Li X, Rak J, et al. Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a\/Src. Signal Transduct Target Ther 2021, 6: 354.","journal-title":"Signal Transduct Target Ther"},{"key":"1564_CR368","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12974-023-02943-2","volume":"20","author":"E Oshima","year":"2023","unstructured":"Oshima E, Hayashi Y, Xie Z, Sato H, Hitomi S, Shibuta I, et al. M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay. J Neuroinflammation 2023, 20: 258.","journal-title":"J Neuroinflammation"},{"key":"1564_CR369","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.4103\/1673-5374.332159","volume":"17","author":"QR He","year":"2022","unstructured":"He QR, Cong M, Yu FH, Ji YH, Yu S, Shi HY, et al. Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons. Neural Regen Res 2022, 17: 1833\u20131840.","journal-title":"Neural Regen Res"},{"key":"1564_CR370","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.actbio.2016.11.064","volume":"50","author":"F Ma","year":"2017","unstructured":"Ma F, Zhu T, Xu F, Wang Z, Zheng Y, Tang Q, et al. Neural stem\/progenitor cells on collagen with anchored basic fibroblast growth factor as potential natural nerve conduits for facial nerve regeneration. Acta Biomater 2017, 50: 188\u2013197.","journal-title":"Acta Biomater"},{"key":"1564_CR371","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14054","volume":"23","author":"J Zhang","year":"2024","unstructured":"Zhang J, Yu H, Man MQ, Hu L. Aging in the dermis: Fibroblast senescence and its significance. Aging Cell 2024, 23: e14054.","journal-title":"Aging Cell"},{"key":"1564_CR372","doi-asserted-by":"publisher","first-page":"H745","DOI":"10.1152\/ajpheart.00237.2018","volume":"315","author":"J Trial","year":"2018","unstructured":"Trial J, Cieslik KA. Changes in cardiac resident fibroblast physiology and phenotype in aging. Am J Physiol Heart Circ Physiol 2018, 315: H745\u2013H755.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1564_CR373","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.actbio.2021.03.039","volume":"126","author":"P Muangsanit","year":"2021","unstructured":"Muangsanit P, Roberton V, Costa E, Phillips JB. Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomater 2021, 126: 224\u2013237.","journal-title":"Acta Biomater"},{"key":"1564_CR374","first-page":"194","volume":"26","author":"Q Yang","year":"2023","unstructured":"Yang Q, Su S, Liu S, Yang S, Xu J, Zhong Y, et al. Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater 2023, 26: 194\u2013215.","journal-title":"Bioact Mater"},{"key":"1564_CR375","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jconrel.2024.01.043","volume":"367","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Yi D, Hong Q, Cao J, Geng X, Liu J, et al. Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration. J Control Release 2024, 367: 265\u2013282.","journal-title":"J Control Release"},{"key":"1564_CR376","first-page":"227","volume":"28","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhang H, Zhang Y, Liu Z, He D, Xu W, et al. Li-Mg-Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration. Bioact Mater 2023, 28: 227\u2013242.","journal-title":"Bioact Mater"},{"key":"1564_CR377","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007429","volume":"33","author":"Z Liu","year":"2021","unstructured":"Liu Z, Wan X, Wang ZL, Li L. Electroactive biomaterials and systems for cell fate determination and tissue regeneration: Design and applications. Adv Mater 2021, 33: e2007429.","journal-title":"Adv Mater"},{"key":"1564_CR378","doi-asserted-by":"publisher","first-page":"6061","DOI":"10.1039\/D2BM01216B","volume":"10","author":"Q Wang","year":"2022","unstructured":"Wang Q, Wang H, Ma Y, Cao X, Gao H. Effects of electroactive materials on nerve cell behaviors and applications in peripheral nerve repair. Biomater Sci 2022, 10: 6061\u20136076.","journal-title":"Biomater Sci"},{"key":"1564_CR379","doi-asserted-by":"publisher","first-page":"814","DOI":"10.4103\/1673-5374.353498","volume":"18","author":"Z Wang","year":"2023","unstructured":"Wang Z, Yi XZ, Yu AX. Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection. Neural Regen Res 2023, 18: 814\u2013818.","journal-title":"Neural Regen Res"},{"key":"1564_CR380","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.actbio.2020.02.003","volume":"106","author":"S Vijayavenkataraman","year":"2020","unstructured":"Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: A review on design, materials and fabrication methods. Acta Biomater 2020, 106: 54\u201369.","journal-title":"Acta Biomater"},{"key":"1564_CR381","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/237507","volume":"2015","author":"A Muheremu","year":"2015","unstructured":"Muheremu A, Ao Q. Past, present, and future of nerve conduits in the treatment of peripheral nerve injury. Biomed Res Int 2015, 2015: 237507.","journal-title":"Biomed Res Int"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01564-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01564-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01564-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:03:33Z","timestamp":1785485013000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01564-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":381,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["1564"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01564-4","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}}]}}