{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:43:17Z","timestamp":1788165797601,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12264-025-01568-0","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T01:10:04Z","timestamp":1766970604000},"page":"1248-1260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SIGMAR1 Drives the Development of Neuropathic Pain by Promoting AMPA Receptor Membrane Trafficking Through Interacting with NPTX1 in Male Mice"],"prefix":"10.1007","volume":"42","author":[{"given":"Jie","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1769-2683","authenticated-orcid":false,"given":"Suyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"1568_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1152\/physrev.00045.2019","volume":"101","author":"NB Finnerup","year":"2021","unstructured":"Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: From mechanisms to treatment. Physiol Rev 2021, 101: 259\u2013301.","journal-title":"Physiol Rev"},{"key":"1568_CR2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","volume":"155","author":"O van Hecke","year":"2014","unstructured":"van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: A systematic review of epidemiological studies. Pain 2014, 155: 654\u2013662.","journal-title":"Pain"},{"key":"1568_CR3","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.semcdb.2006.10.008","volume":"17","author":"D Bleakman","year":"2006","unstructured":"Bleakman D, Alt A, Nisenbaum ES. Glutamate receptors and pain. Semin Cell Dev Biol 2006, 17: 592\u2013604.","journal-title":"Semin Cell Dev Biol"},{"key":"1568_CR4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1113\/jphysiol.2007.145581","volume":"586","author":"KS Vikman","year":"2008","unstructured":"Vikman KS, Rycroft BK, Christie MJ. Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. J Physiol 2008, 586: 515\u2013527.","journal-title":"J Physiol"},{"key":"1568_CR5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/19336950.2021.1885836","volume":"15","author":"O Kopach","year":"2021","unstructured":"Kopach O, Voitenko N. Spinal AMPA receptors: Amenable players in central sensitization for chronic pain therapy? Channels (Austin) 2021, 15: 284\u2013297.","journal-title":"Channels (Austin)"},{"key":"1568_CR6","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/s41467-022-28429-y","volume":"13","author":"RG Xie","year":"2022","unstructured":"Xie RG, Chu WG, Liu DL, Wang X, Ma SB, Wang F. Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain. Nat Commun 2022, 13: 728.","journal-title":"Nat Commun"},{"key":"1568_CR7","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/ALN.0b013e3182a76f74","volume":"120","author":"CD Schuh","year":"2014","unstructured":"Schuh CD, Brenneis C, Zhang DD, Angioni C, Schreiber Y, Ferreiros-Bouzas N, et al. Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors. Anesthesiology 2014, 120: 447\u2013458.","journal-title":"Anesthesiology"},{"key":"1568_CR8","doi-asserted-by":"publisher","first-page":"12531","DOI":"10.1038\/ncomms12531","volume":"7","author":"G Chen","year":"2016","unstructured":"Chen G, Xie RG, Gao YJ, Xu ZZ, Zhao LX, Bang S, et al. \u03b2-arrestin-2 regulates NMDA receptor function in spinal Lamina II neurons and duration of persistent pain. Nat Commun 2016, 7: 12531.","journal-title":"Nat Commun"},{"key":"1568_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.2174\/1570159X11311050002","volume":"11","author":"R Bardoni","year":"2013","unstructured":"Bardoni R. Role of presynaptic glutamate receptors in pain transmission at the spinal cord level. Curr Neuropharmacol 2013, 11: 477\u2013483.","journal-title":"Curr Neuropharmacol"},{"key":"1568_CR10","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.ymthe.2023.01.022","volume":"31","author":"CD Peterson","year":"2023","unstructured":"Peterson CD, Waataja JJ, Kitto KF, Erb SJ, Verma H, Schuster DJ, et al. Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine. Mol Ther 2023, 31: 1123\u20131135.","journal-title":"Mol Ther"},{"key":"1568_CR11","doi-asserted-by":"publisher","first-page":"11111","DOI":"10.3390\/ijms252011111","volume":"25","author":"C Puscasu","year":"2024","unstructured":"Puscasu C, Chirita C, Negres S, Blebea NM. Exploring the therapeutic potential of N-methyl-D-aspartate receptor antagonists in neuropathic pain management. Int J Mol Sci 2024, 25: 11111.","journal-title":"Int J Mol Sci"},{"key":"1568_CR12","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1093\/brain\/awab407","volume":"145","author":"M Coutelier","year":"2022","unstructured":"Coutelier M, Jacoupy M, Janer A, Renaud F, Auger N, Saripella GV, et al. NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar Ataxia. Brain 2022, 145: 1519\u20131534.","journal-title":"Brain"},{"key":"1568_CR13","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1038\/s41467-022-30089-x","volume":"13","author":"K Kanehisa","year":"2022","unstructured":"Kanehisa K, Koga K, Maejima S, Shiraishi Y, Asai K, Shiratori-Hayashi M, et al. Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Nat Commun 2022, 13: 2367.","journal-title":"Nat Commun"},{"key":"1568_CR14","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.biopsych.2019.10.009","volume":"87","author":"Z Wang","year":"2020","unstructured":"Wang Z, Jin T, Le Q, Liu C, Wang X, Wang F, et al. Retrieval-driven hippocampal NPTX2 plasticity facilitates the extinction of cocaine-associated context memory. Biol Psychiatry 2020, 87: 979\u2013991.","journal-title":"Biol Psychiatry"},{"key":"1568_CR15","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/brain\/awac273","volume":"146","author":"A Marcotti","year":"2023","unstructured":"Marcotti A, Fern\u00e1ndez-Trillo J, Gonz\u00e1lez A, Vizca\u00edno-Escoto M, Ros-Arlanz\u00f3n P, Romero L, et al. TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy. Brain 2023, 146: 475\u2013491.","journal-title":"Brain"},{"key":"1568_CR16","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1111\/j.1476-5381.2012.01942.x","volume":"166","author":"L Romero","year":"2012","unstructured":"Romero L, Zamanillo D, Nadal X, S\u00e1nchez-Arroyos R, Rivera-Arconada I, Dordal A, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol 2012, 166: 2289\u20132306.","journal-title":"Br J Pharmacol"},{"key":"1568_CR17","doi-asserted-by":"publisher","first-page":"105339","DOI":"10.1016\/j.phrs.2020.105339","volume":"163","author":"M Carmen Ruiz-Cantero","year":"2021","unstructured":"Carmen Ruiz-Cantero M, Gonz\u00e1lez-Cano R, Tejada M\u00c1, Santos-Caballero M, Perazzoli G, Nieto FR, et al. Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain. Pharmacol Res 2021, 163: 105339.","journal-title":"Pharmacol Res"},{"key":"1568_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41467-023-35795-8","volume":"14","author":"JM Lee","year":"2023","unstructured":"Lee JM, Hammar\u00e9n HM, Savitski MM, Baek SH. Control of protein stability by post-translational modifications. Nat Commun 2023, 14: 201.","journal-title":"Nat Commun"},{"key":"1568_CR19","doi-asserted-by":"publisher","first-page":"126773","DOI":"10.1016\/j.ijbiomac.2023.126773","volume":"253","author":"Y Chen","year":"2023","unstructured":"Chen Y, Jiang Z, Yang Y, Zhang C, Liu H, Wan J. The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives. Int J Biol Macromol 2023, 253: 126773.","journal-title":"Int J Biol Macromol"},{"key":"1568_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41583-019-0244-z","volume":"21","author":"I Livneh","year":"2020","unstructured":"Livneh I, Moshitch-Moshkovitz S, Amariglio N, Rechavi G, Dominissini D. The m6A epitranscriptome: Transcriptome plasticity in brain development and function. Nat Rev Neurosci 2020, 21: 36\u201351.","journal-title":"Nat Rev Neurosci"},{"key":"1568_CR21","doi-asserted-by":"crossref","unstructured":"Xiong X, Hou L, Park YP, Molinie B, Consortium G, Gregory RI, et al. Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet 2021, 53: 1156\u20131165.","DOI":"10.1038\/s41588-021-00890-3"},{"key":"1568_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13045-021-01129-8","volume":"14","author":"W Huang","year":"2021","unstructured":"Huang W, Chen TQ, Fang K, Zeng ZC, Ye H, Chen YQ. N6-methyladenosine methyltransferases: Functions, regulation, and clinical potential. J Hematol Oncol 2021, 14: 117.","journal-title":"J Hematol Oncol"},{"key":"1568_CR23","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41418-020-00706-7","volume":"28","author":"MF Schmidt","year":"2021","unstructured":"Schmidt MF, Gan ZY, Komander D, Dewson G. Ubiquitin signalling in neurodegeneration: Mechanisms and therapeutic opportunities. Cell Death Differ 2021, 28: 570\u2013590.","journal-title":"Cell Death Differ"},{"key":"1568_CR24","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.tibs.2024.06.011","volume":"49","author":"C Zenge","year":"2024","unstructured":"Zenge C, Ordureau A. Ubiquitin system mutations in neurological diseases. Trends Biochem Sci 2024, 49: 875\u2013887.","journal-title":"Trends Biochem Sci"},{"key":"1568_CR25","doi-asserted-by":"publisher","first-page":"e2777","DOI":"10.21769\/BioProtoc.2777","volume":"8","author":"J Cichon","year":"2018","unstructured":"Cichon J, Sun L, Yang G. Spared nerve injury model of neuropathic pain in mice. Bio Protoc 2018, 8: e2777.","journal-title":"Bio Protoc"},{"key":"1568_CR26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","volume":"20","author":"WJ Dixon","year":"1980","unstructured":"Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980, 20: 441\u2013462.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1568_CR27","doi-asserted-by":"publisher","first-page":"e1091","DOI":"10.1002\/cpz1.1091","volume":"4","author":"M Stavrou","year":"2024","unstructured":"Stavrou M, Georgiou E, Kleopa KA. Lumbar intrathecal injection in adult and neonatal mice. Curr Protoc 2024, 4: e1091.","journal-title":"Curr Protoc"},{"key":"1568_CR28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nmeth.1541","volume":"8","author":"H Choi","year":"2011","unstructured":"Choi H, Larsen B, Lin ZY, Breitkreutz A, Mellacheruvu D, Fermin D, et al. SAINT: Probabilistic scoring of affinity purification\u2013mass spectrometry data. Nat Meth 2011, 8: 70\u201373.","journal-title":"Nat Meth"},{"key":"1568_CR29","doi-asserted-by":"publisher","first-page":"1440696","DOI":"10.3389\/fneur.2024.1440696","volume":"15","author":"JP Lefaucheur","year":"2024","unstructured":"Lefaucheur JP, Nguyen JP, Knotkova H, Rossi S, Nizard J. Editorial: Combining a non-invasive transcranial stimulation technique with another therapeutic approach: Mechanisms of action, therapeutic interest and tolerance. Front Neurol 2024, 15: 1440696.","journal-title":"Front Neurol"},{"key":"1568_CR30","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/medicina60071020","volume":"60","author":"R Rispoli","year":"2024","unstructured":"Rispoli R, Giorgiutti F, Veltri C, Copetti E, Imbruce\u2019 P, Iacopino G, et al. The efficacy of a multidisciplinary approach and diagnostic-therapeutic algorithm for vertebral metastases with spinal cord compression. Medicina (Kaunas) 2024, 60: 1020.","journal-title":"Medicina (Kaunas)"},{"key":"1568_CR31","doi-asserted-by":"publisher","first-page":"174480691774968","DOI":"10.1177\/1744806917749683","volume":"14","author":"E Salvat","year":"2018","unstructured":"Salvat E, Yalcin I, Muller A, Barrot M. A comparison of early and late treatments on allodynia and its chronification in experimental neuropathic pain. Mol Pain 2018, 14: 1744806917749683.","journal-title":"Mol Pain"},{"key":"1568_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12974-022-02489-9","volume":"19","author":"J Li","year":"2022","unstructured":"Li J, Wei Y, Zhou J, Zou H, Ma L, Liu C, et al. Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. J Neuroinflammation 2022, 19: 123.","journal-title":"J Neuroinflammation"},{"key":"1568_CR33","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1016\/j.neuron.2022.06.014","volume":"110","author":"H Yu","year":"2022","unstructured":"Yu H, Cranfill SL, Luo W. ErbB4+ spinal cord dorsal horn neurons process heat pain. Neuron 2022, 110: 2206\u20132208.","journal-title":"Neuron"},{"key":"1568_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","volume":"131","author":"N Attal","year":"2023","unstructured":"Attal N, Bouhassira D, Colvin L. Advances and challenges in neuropathic pain: A narrative review and future directions. Br J Anaesth 2023, 131: 79\u201392.","journal-title":"Br J Anaesth"},{"key":"1568_CR35","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/ejp.2120","volume":"27","author":"D Bouhassira","year":"2023","unstructured":"Bouhassira D, Attal N. Personalized treatment of neuropathic pain: Where are we now? Eur J Pain 2023, 27: 1084\u20131098.","journal-title":"Eur J Pain"},{"key":"1568_CR36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s44254-025-00093-7","volume":"3","author":"Y Dong","year":"2025","unstructured":"Dong Y, Zeng H, Yang L, Song H, Li Q. Prognostic prediction model for chronic postsurgical pain among adult patients: A systematic review and meta-analysis. Anesthesiol Perioper Sci 2025, 3: 14.","journal-title":"Anesthesiol Perioper Sci"},{"key":"1568_CR37","doi-asserted-by":"crossref","unstructured":"Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem 2000, 275: 17786\u201317792.","DOI":"10.1074\/jbc.M002254200"},{"key":"1568_CR38","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0896-6273(00)80782-5","volume":"23","author":"RJ O\u2019Brien","year":"1999","unstructured":"O\u2019Brien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 1999, 23: 309\u2013323.","journal-title":"Neuron"},{"key":"1568_CR39","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1007\/s00415-015-7725-4","volume":"262","author":"M Coutelier","year":"2015","unstructured":"Coutelier M, Stevanin G, Brice A. Genetic landscape remodelling in spinocerebellar ataxias: The influence of next-generation sequencing. J Neurol 2015, 262: 2382\u20132395.","journal-title":"J Neurol"},{"key":"1568_CR40","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuron.2007.06.020","volume":"55","author":"GM Sia","year":"2007","unstructured":"Sia GM, B\u00e9\u00efque JC, Rumbaugh G, Cho R, Worley PF, Huganir RL. Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron 2007, 55: 87\u2013102.","journal-title":"Neuron"},{"key":"1568_CR41","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1074\/jbc.M007967200","volume":"276","author":"N DeGregorio-Rocasolano","year":"2001","unstructured":"DeGregorio-Rocasolano N, Gasull T, Trullas R. Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K+ in cerebellar granule cells. J Biol Chem 2001, 276: 796\u2013803.","journal-title":"J Biol Chem"},{"key":"1568_CR42","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1126\/science.284.5421.1805","volume":"284","author":"D Zamanillo","year":"1999","unstructured":"Zamanillo D, Sprengel R, Hvalby O, Jensen V, Burnashev N, Rozov A, et al. Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science 1999, 284: 1805\u20131811.","journal-title":"Science"},{"key":"1568_CR43","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","volume":"7","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhao J, Zhong K, Tong A, Jia D. Targeted protein degradation: Mechanisms, strategies and application. Signal Transduct Target Ther 2022, 7: 113.","journal-title":"Signal Transduct Target Ther"},{"key":"1568_CR44","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41418-020-00703-w","volume":"28","author":"RB Damgaard","year":"2021","unstructured":"Damgaard RB. The ubiquitin system: From cell signalling to disease biology and new therapeutic opportunities. Cell Death Differ 2021, 28: 423\u2013426.","journal-title":"Cell Death Differ"},{"key":"1568_CR45","doi-asserted-by":"publisher","first-page":"e15373","DOI":"10.15252\/emmm.202115373","volume":"14","author":"X Wei","year":"2022","unstructured":"Wei X, Zheng Z, Feng Z, Zheng L, Tao S, Zheng B, et al. Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2. EMBO Mol Med 2022, 14: e15373.","journal-title":"EMBO Mol Med"},{"key":"1568_CR46","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, et al. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther 2021, 6: 74.","journal-title":"Signal Transduct Target Ther"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01568-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01568-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01568-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:02:40Z","timestamp":1780084960000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01568-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1568"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01568-0","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"8 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols and the use of the animals were reviewed and approved by the Second Affiliated Hospital of Guangzhou Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}