{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:55:42Z","timestamp":1783828542692,"version":"3.55.0"},"reference-count":210,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12264-025-01584-0","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:31:48Z","timestamp":1770489108000},"page":"1151-1176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Current Advances and Applications of Retinal Organoids"],"prefix":"10.1007","volume":"42","author":[{"given":"Dan-Ni","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-9688","authenticated-orcid":false,"given":"Shu-Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-9808","authenticated-orcid":false,"family":"Saijilafu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-9969","authenticated-orcid":false,"given":"Feng-Quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"1584_CR1","doi-asserted-by":"publisher","first-page":"9027","DOI":"10.1126\/sciadv.abm9027","volume":"8","author":"AL Liu","year":"2022","unstructured":"Liu AL, Liu YF, Wang G, Shao YQ, Yu CX, Yang Z. The role of ipRGCs in ocular growth and myopia development. Sci Adv 2022, 8: 9027.","journal-title":"Sci Adv"},{"key":"1584_CR2","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2337\/db20-0775","volume":"70","author":"WY Chen","year":"2021","unstructured":"Chen WY, Han X, Cui LJ, Yu CX, Sheng WL, Yu J, et al. Cell-subtype-specific remodeling of intrinsically photosensitive retinal ganglion cells in streptozotocin-induced diabetic mice. Diabetes 2021, 70: 1157\u20131169.","journal-title":"Diabetes"},{"key":"1584_CR3","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1073\/pnas.1706193114","volume":"114","author":"A Jain","year":"2017","unstructured":"Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, et al. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A 2017, 114: 11199\u201311204.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR4","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.3390\/ijms23136883","volume":"23","author":"SV Patil","year":"2022","unstructured":"Patil SV, Kasetti RB, Millar JC, Zode GS. A novel mouse model of TGF\u03b22-induced ocular hypertension using lentiviral gene delivery. Int J Mol Sci 2022, 23: 6883.","journal-title":"Int J Mol Sci"},{"key":"1584_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.preteyeres.2015.04.004","volume":"48","author":"RWN Slijkerman","year":"2015","unstructured":"Slijkerman RWN, Song F, Astuti GDN, Huynen MA, van Wijk E, Stieger K, et al. The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies. Prog Retin Eye Res 2015, 48: 137\u2013159.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR6","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/17383","volume":"397","author":"A Roorda","year":"1999","unstructured":"Roorda A, Williams DR. The arrangement of the three cone classes in the living human eye. Nature 1999, 397: 520\u2013522.","journal-title":"Nature"},{"key":"1584_CR7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1085\/jgp.200609490","volume":"127","author":"SS Nikonov","year":"2006","unstructured":"Nikonov SS, Kholodenko R, Lem J, Pugh EN Jr. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. J Gen Physiol 2006, 127: 359\u2013374.","journal-title":"J Gen Physiol"},{"key":"1584_CR8","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cell.2019.01.004","volume":"176","author":"YR Peng","year":"2019","unstructured":"Peng YR, Shekhar K, Yan W, Herrmann D, Sappington A, Bryman GS, et al. Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina. Cell 2019, 176: 1222-1237.e22.","journal-title":"Cell"},{"key":"1584_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrd.2016.245","volume":"16","author":"Y Shi","year":"2017","unstructured":"Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: A decade of progress. Nat Rev Drug Discov 2017, 16: 115\u2013130.","journal-title":"Nat Rev Drug Discov"},{"key":"1584_CR10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1152\/physrev.00039.2017","volume":"99","author":"P Karagiannis","year":"2019","unstructured":"Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, et al. Induced pluripotent stem cells and their use in human models of disease and development. Physiol Rev 2019, 99: 79\u2013114.","journal-title":"Physiol Rev"},{"key":"1584_CR11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","volume":"10","author":"T Nakano","year":"2012","unstructured":"Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 2012, 10: 771\u2013785.","journal-title":"Cell Stem Cell"},{"key":"1584_CR12","doi-asserted-by":"publisher","first-page":"16698","DOI":"10.1073\/pnas.0905245106","volume":"106","author":"JS Meyer","year":"2009","unstructured":"Meyer JS, Shearer RL, Capowski EE, Wright LS, Wallace KA, McMillan EL, et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci U S A 2009, 106: 16698\u201316703.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR13","doi-asserted-by":"publisher","first-page":"8518","DOI":"10.1073\/pnas.1324212111","volume":"111","author":"S Reichman","year":"2014","unstructured":"Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, et al. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Proc Natl Acad Sci U S A 2014, 111: 8518\u20138523.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR14","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.cell.2020.08.013","volume":"182","author":"CS Cowan","year":"2020","unstructured":"Cowan CS, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, et al. Cell types of the human retina and its organoids at single-cell resolution. Cell 2020, 182: 1623-1640.e34.","journal-title":"Cell"},{"key":"1584_CR15","doi-asserted-by":"publisher","first-page":"10824","DOI":"10.1073\/pnas.1901572116","volume":"116","author":"S Kim","year":"2019","unstructured":"Kim S, Lowe A, Dharmat R, Lee S, Owen LA, Wang J, et al. Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids. Proc Natl Acad Sci U S A 2019, 116: 10824\u201310833.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR16","doi-asserted-by":"publisher","first-page":"E81","DOI":"10.1073\/pnas.1512590113","volume":"113","author":"H Shirai","year":"2016","unstructured":"Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, et al. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A 2016, 113: E81\u2013E90.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.stemcr.2019.09.010","volume":"13","author":"KC Huang","year":"2019","unstructured":"Huang KC, Wang ML, Chen SJ, Kuo JC, Wang WJ, Nhi Nguyen PN, et al. Morphological and molecular defects in human three-dimensional retinal organoid model of X-linked juvenile retinoschisis. Stem Cell Reports 2019, 13: 906\u2013923.","journal-title":"Stem Cell Reports"},{"key":"1584_CR18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fcell.2020.00128","volume":"8","author":"ML Gao","year":"2020","unstructured":"Gao ML, Lei XL, Han F, He KW, Jin SQ, Zhang YY, et al. Patient-specific retinal organoids recapitulate disease features of late-onset retinitis pigmentosa. Front Cell Dev Biol 2020, 8: 128.","journal-title":"Front Cell Dev Biol"},{"key":"1584_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajo.2019.04.033","volume":"206","author":"DM Gamm","year":"2019","unstructured":"Gamm DM, Clark E, Capowski EE, Singh R. The role of FGF9 in the production of neural retina and RPE in a pluripotent stem cell model of early human retinal development. Am J Ophthalmol 2019, 206: 113\u2013131.","journal-title":"Am J Ophthalmol"},{"key":"1584_CR20","doi-asserted-by":"publisher","first-page":"15664","DOI":"10.1038\/s41598-018-34037-y","volume":"8","author":"D Saengwimol","year":"2018","unstructured":"Saengwimol D, Rojanaporn D, Chaitankar V, Chittavanich P, Aroonroch R, Boontawon T, et al. A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma. Sci Rep 2018, 8: 15664.","journal-title":"Sci Rep"},{"key":"1584_CR21","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.stemcr.2020.12.018","volume":"16","author":"K Kruczek","year":"2021","unstructured":"Kruczek K, Qu Z, Gentry J, Fadl BR, Gieser L, Hiriyanna S, et al. Gene therapy of dominant CRX-leber congenital amaurosis using patient stem cell-derived retinal organoids. Stem Cell Reports 2021, 16: 252\u2013263.","journal-title":"Stem Cell Reports"},{"key":"1584_CR22","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1080\/14712598.2020.1740676","volume":"20","author":"TA Ciulla","year":"2020","unstructured":"Ciulla TA, Hussain RM, Berrocal AM, Nagiel A. Voretigene neparvovec-rzyl for treatment of RPE65-mediated inherited retinal diseases: A model for ocular gene therapy development. Expert Opin Biol Ther 2020, 20: 565\u2013578.","journal-title":"Expert Opin Biol Ther"},{"key":"1584_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s42003-020-0808-5","volume":"3","author":"A Kallman","year":"2020","unstructured":"Kallman A, Capowski EE, Wang J, Kaushik AM, Jansen AD, Edwards KL, et al. Investigating cone photoreceptor development using patient-derived NRL null retinal organoids. Commun Biol 2020, 3: 82.","journal-title":"Commun Biol"},{"key":"1584_CR24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ydbio.2021.09.001","volume":"480","author":"KC Eldred","year":"2021","unstructured":"Eldred KC, Reh TA. Human retinal model systems: Strengths, weaknesses, and future directions. Dev Biol 2021, 480: 114\u2013122.","journal-title":"Dev Biol"},{"key":"1584_CR25","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/292154a0","volume":"292","author":"MJ Evans","year":"1981","unstructured":"Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292: 154\u2013156.","journal-title":"Nature"},{"key":"1584_CR26","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","volume":"282","author":"JA Thomson","year":"1998","unstructured":"Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998, 282: 1145\u20131147.","journal-title":"Science"},{"key":"1584_CR27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126: 663\u2013676.","journal-title":"Cell"},{"key":"1584_CR28","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131: 861\u2013872.","journal-title":"Cell"},{"key":"1584_CR29","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318: 1917\u20131920.","journal-title":"Science"},{"key":"1584_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1126\/science.1172482","volume":"324","author":"J Yu","year":"2009","unstructured":"Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009, 324: 797\u2013801.","journal-title":"Science"},{"key":"1584_CR31","doi-asserted-by":"publisher","first-page":"12769","DOI":"10.1073\/pnas.0601990103","volume":"103","author":"DA Lamba","year":"2006","unstructured":"Lamba DA, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A 2006, 103: 12769\u201312774.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR32","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S1534-5807(01)00041-7","volume":"1","author":"M Mukhopadhyay","year":"2001","unstructured":"Mukhopadhyay M, Shtrom S, Rodriguez-Esteban C, Chen L, Tsukui T, Gomer L, et al. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell 2001, 1: 423\u2013434.","journal-title":"Dev Cell"},{"key":"1584_CR33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1126\/science.8235591","volume":"262","author":"TM Lamb","year":"1993","unstructured":"Lamb TM, Knecht AK, Smith WC, Stachel SE, Economides AN, Stahl N, et al. Neural induction by the secreted polypeptide noggin. Science 1993, 262: 713\u2013718.","journal-title":"Science"},{"key":"1584_CR34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/361547a0","volume":"361","author":"WC Smith","year":"1993","unstructured":"Smith WC, Knecht AK, Wu M, Harland RM. Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature 1993, 361: 547\u2013549.","journal-title":"Nature"},{"key":"1584_CR35","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S1534-5807(01)00069-7","volume":"1","author":"EM Pera","year":"2001","unstructured":"Pera EM, Wessely O, Li SY, De Robertis EM. Neural and head induction by insulin-like growth factor signals. Dev Cell 2001, 1: 655\u2013665.","journal-title":"Dev Cell"},{"key":"1584_CR36","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1242\/dev.129.21.4975","volume":"129","author":"RM Anderson","year":"2002","unstructured":"Anderson RM, Lawrence AR, Stottmann RW, Bachiller D, Klingensmith J. Chordin and noggin promote organizing centers of forebrain development in the mouse. Development 2002, 129: 4975\u20134987.","journal-title":"Development"},{"key":"1584_CR37","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/35001072","volume":"403","author":"D Bachiller","year":"2000","unstructured":"Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, et al. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 2000, 403: 658\u2013661.","journal-title":"Nature"},{"key":"1584_CR38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nbt1384","volume":"26","author":"F Osakada","year":"2008","unstructured":"Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol 2008, 26: 215\u2013224.","journal-title":"Nat Biotechnol"},{"key":"1584_CR39","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1634\/stemcells.2005-0507","volume":"24","author":"M Tomita","year":"2006","unstructured":"Tomita M, Mori T, Maruyama K, Zahir T, Ward M, Umezawa A, et al. A comparison of neural differentiation and retinal transplantation with bone marrow-derived cells and retinal progenitor cells. Stem Cells 2006, 24: 2270\u20132278.","journal-title":"Stem Cells"},{"key":"1584_CR40","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1634\/stemcells.2005-0009","volume":"24","author":"E Banin","year":"2006","unstructured":"Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, et al. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 2006, 24: 246\u2013257.","journal-title":"Stem Cells"},{"key":"1584_CR41","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.stem.2013.11.002","volume":"13","author":"G Schwank","year":"2013","unstructured":"Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, et al. Functional repair of CFTR by CRISPR\/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013, 13: 653\u2013658.","journal-title":"Cell Stem Cell"},{"key":"1584_CR42","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459: 262\u2013265.","journal-title":"Nature"},{"key":"1584_CR43","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nm.3201","volume":"19","author":"JF Dekkers","year":"2013","unstructured":"Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med 2013, 19: 939\u2013945.","journal-title":"Nat Med"},{"key":"1584_CR44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.stem.2008.09.002","volume":"3","author":"M Eiraku","year":"2008","unstructured":"Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, et al. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 2008, 3: 519\u2013532.","journal-title":"Cell Stem Cell"},{"key":"1584_CR45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nature12517","volume":"501","author":"MA Lancaster","year":"2013","unstructured":"Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, et al. Cerebral organoids model human brain development and microcephaly. Nature 2013, 501: 373\u2013379.","journal-title":"Nature"},{"key":"1584_CR46","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nbt.3906","volume":"35","author":"MA Lancaster","year":"2017","unstructured":"Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, et al. Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol 2017, 35: 659\u2013666.","journal-title":"Nat Biotechnol"},{"key":"1584_CR47","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41596-018-0104-8","volume":"14","author":"AJ Miller","year":"2019","unstructured":"Miller AJ, Dye BR, Ferrer-Torres D, Hill DR, Overeem AW, Shea LD, et al. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc 2019, 14: 518\u2013540.","journal-title":"Nat Protoc"},{"key":"1584_CR48","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.stem.2019.06.009","volume":"25","author":"JH Low","year":"2019","unstructured":"Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, et al. Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell 2019, 25: 373-387.e9.","journal-title":"Cell Stem Cell"},{"key":"1584_CR49","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/nbt.3392","volume":"33","author":"R Morizane","year":"2015","unstructured":"Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol 2015, 33: 1193\u20131200.","journal-title":"Nat Biotechnol"},{"key":"1584_CR50","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s41587-021-00815-9","volume":"39","author":"L Drakhlis","year":"2021","unstructured":"Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, et al. Human heart-forming organoids recapitulate early heart and foregut development. Nat Biotechnol 2021, 39: 737\u2013746.","journal-title":"Nat Biotechnol"},{"key":"1584_CR51","first-page":"1008","volume":"144","author":"E Giacomelli","year":"2017","unstructured":"Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LGJ, Orlova VV, et al. Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development 2017, 144: 1008\u20131017.","journal-title":"Development"},{"key":"1584_CR52","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41551-020-0539-4","volume":"4","author":"DJ Richards","year":"2020","unstructured":"Richards DJ, Li Y, Kerr CM, Yao J, Beeson GC, Coyle RC, et al. Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity. Nat Biomed Eng 2020, 4: 446\u2013462.","journal-title":"Nat Biomed Eng"},{"key":"1584_CR53","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.cell.2017.11.010","volume":"172","author":"N Sachs","year":"2018","unstructured":"Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, et al. A living biobank of breast cancer organoids captures disease heterogeneity. Cell 2018, 172: 373-386.e10.","journal-title":"Cell"},{"key":"1584_CR54","doi-asserted-by":"publisher","first-page":"1247125","DOI":"10.1126\/science.1247125","volume":"345","author":"MA Lancaster","year":"2014","unstructured":"Lancaster MA, Knoblich JA. Organogenesis in a dish: Modeling development and disease using organoid technologies. Science 2014, 345: 1247125.","journal-title":"Science"},{"key":"1584_CR55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nature09941","volume":"472","author":"M Eiraku","year":"2011","unstructured":"Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 2011, 472: 51\u201356.","journal-title":"Nature"},{"key":"1584_CR56","doi-asserted-by":"publisher","first-page":"11331","DOI":"10.1073\/pnas.0500010102","volume":"102","author":"H Ikeda","year":"2005","unstructured":"Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, et al. Generation of Rx+\/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A 2005, 102: 11331\u201311336.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR57","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neulet.2009.04.035","volume":"458","author":"Y Hirami","year":"2009","unstructured":"Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, et al. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett 2009, 458: 126\u2013131.","journal-title":"Neurosci Lett"},{"key":"1584_CR58","doi-asserted-by":"publisher","first-page":"e18992","DOI":"10.1371\/journal.pone.0018992","volume":"6","author":"BA Tucker","year":"2011","unstructured":"Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, et al. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One 2011, 6: e18992.","journal-title":"PLoS One"},{"key":"1584_CR59","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/stem.1037","volume":"30","author":"CB Mellough","year":"2012","unstructured":"Mellough CB, Sernagor E, Moreno-Gimeno I, Steel DHW, Lako M. Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells. Stem Cells 2012, 30: 673\u2013686.","journal-title":"Stem Cells"},{"key":"1584_CR60","doi-asserted-by":"publisher","first-page":"6286","DOI":"10.1038\/ncomms7286","volume":"6","author":"A Kuwahara","year":"2015","unstructured":"Kuwahara A, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y. Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nat Commun 2015, 6: 6286.","journal-title":"Nat Commun"},{"key":"1584_CR61","first-page":"3294","volume":"142","author":"S Zhou","year":"2015","unstructured":"Zhou S, Flamier A, Abdouh M, T\u00e9treault N, Barabino A, Wadhwa S, et al. Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP. TGF\u03b2 and Wnt signaling. Development 2015, 142: 3294\u20133306.","journal-title":"TGF\u03b2 and Wnt signaling. Development"},{"key":"1584_CR62","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.stem.2010.06.018","volume":"7","author":"M Ohgushi","year":"2010","unstructured":"Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, et al. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell 2010, 7: 225\u2013239.","journal-title":"Cell Stem Cell"},{"key":"1584_CR63","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.stem.2010.06.017","volume":"7","author":"G Chen","year":"2010","unstructured":"Chen G, Hou Z, Gulbranson DR, Thomson JA. Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 2010, 7: 240\u2013248.","journal-title":"Cell Stem Cell"},{"key":"1584_CR64","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.stemcr.2016.03.011","volume":"6","author":"A Lowe","year":"2016","unstructured":"Lowe A, Harris R, Bhansali P, Cvekl A, Liu W. Intercellular adhesion-dependent cell survival and ROCK-regulated actomyosin-driven forces mediate self-formation of a retinal organoid. Stem Cell Reports 2016, 6: 743\u2013756.","journal-title":"Stem Cell Reports"},{"key":"1584_CR65","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1523\/JNEUROSCI.3664-04.2005","volume":"25","author":"X Yi","year":"2005","unstructured":"Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, et al. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci 2005, 25: 1240\u20131248.","journal-title":"J Neurosci"},{"key":"1584_CR66","doi-asserted-by":"publisher","first-page":"169474","DOI":"10.1242\/dev.169474","volume":"146","author":"CB Mellough","year":"2019","unstructured":"Mellough CB, Bauer R, Collin J, Dorgau B, Zerti D, Dolan DWP, et al. An integrated transcriptional analysis of the developing human retina. Development 2019, 146: 169474.","journal-title":"Development"},{"key":"1584_CR67","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/stem.3082","volume":"38","author":"D Zerti","year":"2020","unstructured":"Zerti D, Dorgau B, Felemban M, Ghareeb AE, Yu M, Ding Y, et al. Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids. Stem Cells 2020, 38: 45\u201351.","journal-title":"Stem Cells"},{"key":"1584_CR68","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/15513810802679498","volume":"28","author":"D Coppola","year":"2009","unstructured":"Coppola D, Ouban A, Gilbert-Barness E. Expression of the insulin-like growth factor receptor 1 during human embryogenesis. Fetal Pediatr Pathol 2009, 28: 47\u201354.","journal-title":"Fetal Pediatr Pathol"},{"key":"1584_CR69","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/sctm.17-0205","volume":"7","author":"J Zhu","year":"2018","unstructured":"Zhu J, Reynolds J, Garcia T, Cifuentes H, Chew S, Zeng X, et al. Generation of transplantable retinal photoreceptors from a current good manufacturing practice-manufactured human induced pluripotent stem cell line. Stem Cells Transl Med 2018, 7: 210\u2013219.","journal-title":"Stem Cells Transl Med"},{"key":"1584_CR70","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1038\/ncomms5047","volume":"5","author":"X Zhong","year":"2014","unstructured":"Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, et al. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun 2014, 5: 4047.","journal-title":"Nat Commun"},{"key":"1584_CR71","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.stem.2009.07.002","volume":"5","author":"M Idelson","year":"2009","unstructured":"Idelson M, Alper R, Obolensky A, Ben-Shushan E, Hemo I, Yachimovich-Cohen N, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell 2009, 5: 396\u2013408.","journal-title":"Cell Stem Cell"},{"key":"1584_CR72","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1002\/stem.674","volume":"29","author":"JS Meyer","year":"2011","unstructured":"Meyer JS, Howden SE, Wallace KA, Verhoeven AD, Wright LS, Capowski EE, et al. Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells 2011, 29: 1206\u20131218.","journal-title":"Stem Cells"},{"key":"1584_CR73","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/stem.3116","volume":"38","author":"V Chichagova","year":"2020","unstructured":"Chichagova V, Hilgen G, Ghareeb A, Georgiou M, Carter M, Sernagor E, et al. Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent. Stem Cells 2020, 38: 195\u2013201.","journal-title":"Stem Cells"},{"key":"1584_CR74","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1002\/stem.2586","volume":"35","author":"S Reichman","year":"2017","unstructured":"Reichman S, Slembrouck A, Gagliardi G, Chaffiol A, Terray A, Nanteau C, et al. Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions. Stem Cells 2017, 35: 1176\u20131188.","journal-title":"Stem Cells"},{"key":"1584_CR75","first-page":"663","volume":"25","author":"KD Kaya","year":"2019","unstructured":"Kaya KD, Chen HY, Brooks MJ, Kelley RA, Shimada H, Nagashima K, et al. Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-Cis retinal. Mol Vis 2019, 25: 663\u2013678.","journal-title":"Mol Vis"},{"key":"1584_CR76","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.stemcr.2022.04.003","volume":"17","author":"M Fernando","year":"2022","unstructured":"Fernando M, Lee S, Wark JR, Xiao D, Lim BY, O\u2019Hara-Wright M, et al. Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin. Stem Cell Reports 2022, 17: 1476\u20131492.","journal-title":"Stem Cell Reports"},{"key":"1584_CR77","doi-asserted-by":"publisher","first-page":"149509","DOI":"10.1016\/j.bbrc.2024.149509","volume":"700","author":"G Li","year":"2024","unstructured":"Li G, Luo Y. Enriching new transplantable RGC-like cells from retinal organoids for RGC replacement therapy. Biochem Biophys Res Commun 2024, 700: 149509.","journal-title":"Biochem Biophys Res Commun"},{"key":"1584_CR78","doi-asserted-by":"publisher","first-page":"e2317285121","DOI":"10.1073\/pnas.2317285121","volume":"121","author":"J Harkin","year":"2024","unstructured":"Harkin J, Pe\u00f1a KH, Gomes C, Hernandez M, Lavekar SS, So K, et al. A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells. Proc Natl Acad Sci U S A 2024, 121: e2317285121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR79","doi-asserted-by":"crossref","unstructured":"Liu CF, Wong NK, Yip SP, Huang CL. Retinal organoid differentiation strategies and their application in retinal degenerative disease modeling. In: Advances in Using Stem Cells to Treat Neural Diseases. Springer Nature Switzerland, 2025: 175\u2013187.","DOI":"10.1007\/978-3-031-94101-6_9"},{"key":"1584_CR80","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.survophthal.2023.09.003","volume":"69","author":"K Chakrabarty","year":"2024","unstructured":"Chakrabarty K, Nayak D, Debnath J, Das D, Shetty R, Ghosh A. Retinal organoids in disease modeling and drug discovery: Opportunities and challenges. Surv Ophthalmol 2024, 69: 179\u2013189.","journal-title":"Surv Ophthalmol"},{"key":"1584_CR81","first-page":"3311","volume":"58","author":"AW Browne","year":"2017","unstructured":"Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, et al. Structural and functional characterization of human stem-cell-derived retinal organoids by live imaging. Invest Ophthalmol Vis Sci 2017, 58: 3311\u20133318.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR82","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","volume":"94","author":"I Aldiri","year":"2017","unstructured":"Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, et al. The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis. Neuron 2017, 94: 550-568.e10.","journal-title":"Neuron"},{"key":"1584_CR83","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.devcel.2017.10.029","volume":"43","author":"A Hoshino","year":"2017","unstructured":"Hoshino A, Ratnapriya R, Brooks MJ, Chaitankar V, Wilken MS, Zhang C, et al. Molecular anatomy of the developing human retina. Dev Cell 2017, 43: 763-779.e4.","journal-title":"Dev Cell"},{"key":"1584_CR84","doi-asserted-by":"crossref","unstructured":"Farkas MH, Grant GR, White JA, Sousa ME, Consugar MB, Pierce EA. Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes. BMC Genomics 2013, 14: 486.","DOI":"10.1186\/1471-2164-14-486"},{"key":"1584_CR85","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1093\/hmg\/ddu114","volume":"23","author":"M Li","year":"2014","unstructured":"Li M, Jia C, Kazmierkiewicz KL, Bowman AS, Tian L, Liu Y, et al. Comprehensive analysis of gene expression in human retina and supporting tissues. Hum Mol Genet 2014, 23: 4001\u20134014.","journal-title":"Hum Mol Genet"},{"key":"1584_CR86","doi-asserted-by":"publisher","first-page":"101244","DOI":"10.1016\/j.preteyeres.2024.101244","volume":"100","author":"M Georgiou","year":"2024","unstructured":"Georgiou M, Robson AG, Fujinami K, de Guimar\u00e3es TAC, Fujinami-Yokokawa Y, Daich Varela M, et al. Phenotyping and genotyping inherited retinal diseases: Molecular genetics, clinical and imaging features, and therapeutics of macular dystrophies, cone and cone-rod dystrophies, rod-cone dystrophies, Leber congenital amaurosis, and cone dysfunction syndromes. Prog Retin Eye Res 2024, 100: 101244.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR87","doi-asserted-by":"publisher","first-page":"e2210104119","DOI":"10.1073\/pnas.2210104119","volume":"119","author":"S Suh","year":"2022","unstructured":"Suh S, Choi EH, Raguram A, Liu DR, Palczewski K. Precision genome editing in the eye. Proc Natl Acad Sci U S A 2022, 119: e2210104119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR88","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrg2717","volume":"11","author":"AF Wright","year":"2010","unstructured":"Wright AF, Chakarova CF, Abd El-Aziz MM, Bhattacharya SS. Photoreceptor degeneration: Genetic and mechanistic dissection of a complex trait. Nat Rev Genet 2010, 11: 273\u2013284.","journal-title":"Nat Rev Genet"},{"key":"1584_CR89","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1242\/dmm.017913","volume":"8","author":"S Veleri","year":"2015","unstructured":"Veleri S, Lazar CH, Chang B, Sieving PA, Banin E, Swaroop A. Biology and therapy of inherited retinal degenerative disease: Insights from mouse models. Dis Model Mech 2015, 8: 109\u2013129.","journal-title":"Dis Model Mech"},{"key":"1584_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2015.12.003","volume":"122","author":"KD Onos","year":"2016","unstructured":"Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M. Toward more predictive genetic mouse models of Alzheimer\u2019s disease. Brain Res Bull 2016, 122: 1\u201311.","journal-title":"Brain Res Bull"},{"key":"1584_CR91","doi-asserted-by":"publisher","first-page":"732382","DOI":"10.3389\/fcell.2021.732382","volume":"9","author":"J Li","year":"2021","unstructured":"Li J, Chen Y, Ouyang S, Ma J, Sun H, Luo L, et al. Generation and staging of human retinal organoids based on self-formed ectodermal autonomous multi-zone system. Front Cell Dev Biol 2021, 9: 732382.","journal-title":"Front Cell Dev Biol"},{"key":"1584_CR92","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12929-017-0362-8","volume":"24","author":"CT Lee","year":"2017","unstructured":"Lee CT, Bendriem RM, Wu WW, Shen RF. 3D brain Organoids derived from pluripotent stem cells: Promising experimental models for brain development and neurodegenerative disorders. J Biomed Sci 2017, 24: 59.","journal-title":"J Biomed Sci"},{"key":"1584_CR93","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.stemcr.2017.07.022","volume":"9","author":"A Gonzalez-Cordero","year":"2017","unstructured":"Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, et al. Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors. Stem Cell Reports 2017, 9: 820\u2013837.","journal-title":"Stem Cell Reports"},{"key":"1584_CR94","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s12264-024-01189-z","volume":"40","author":"Y Ji","year":"2024","unstructured":"Ji Y, McLean JL, Xu R. Emerging human pluripotent stem cell-based human-animal brain chimeras for advancing disease modeling and cell therapy for neurological disorders. Neurosci Bull 2024, 40: 1315\u20131332.","journal-title":"Neurosci Bull"},{"key":"1584_CR95","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1001\/archopht.125.2.151","volume":"125","author":"SP Daiger","year":"2007","unstructured":"Daiger SP, Bowne SJ, Sullivan LS. Perspective on genes and mutations causing retinitis pigmentosa. Arch Ophthalmol 2007, 125: 151\u2013158.","journal-title":"Arch Ophthalmol"},{"key":"1584_CR96","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.preteyeres.2015.06.005","volume":"48","author":"V Guadagni","year":"2015","unstructured":"Guadagni V, Novelli E, Piano I, Gargini C, Strettoi E. Pharmacological approaches to retinitis pigmentosa: A laboratory perspective. Prog Retin Eye Res 2015, 48: 62\u201381.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR97","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1750-1172-1-40","volume":"1","author":"C Hamel","year":"2006","unstructured":"Hamel C. Retinitis pigmentosa. Orphanet J Rare Dis 2006, 1: 40.","journal-title":"Orphanet J Rare Dis"},{"key":"1584_CR98","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.3390\/ijms23094883","volume":"23","author":"W Liu","year":"2022","unstructured":"Liu W, Liu S, Li P, Yao K. Retinitis pigmentosa: Progress in molecular pathology and biotherapeutical strategies. Int J Mol Sci 2022, 23: 4883.","journal-title":"Int J Mol Sci"},{"key":"1584_CR99","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.preteyeres.2017.10.004","volume":"63","author":"MF Dias","year":"2018","unstructured":"Dias MF, Joo K, Kemp JA, Fialho SL, da Silva Cunha A, Woo SJ, et al. Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives. Prog Retin Eye Res 2018, 63: 107\u2013131.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR100","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/biom14080903","volume":"14","author":"Y Liu","year":"2024","unstructured":"Liu Y, Zong X, Cao W, Zhang W, Zhang N, Yang N. Gene therapy for retinitis pigmentosa: Current challenges and new progress. Biomolecules 2024, 14: 903.","journal-title":"Biomolecules"},{"key":"1584_CR101","first-page":"e64045","volume":"184","author":"C Ma","year":"2022","unstructured":"Ma C, Jin K, Jin ZB. Generation of human patient iPSC-derived retinal organoids to model retinitis pigmentosa. J Vis Exp 2022, 184: e64045.","journal-title":"J Vis Exp"},{"key":"1584_CR102","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.stemcr.2018.02.003","volume":"10","author":"WL Deng","year":"2018","unstructured":"Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, et al. Gene correction reverses ciliopathy and photoreceptor loss in iPSC-derived retinal organoids from retinitis pigmentosa patients. Stem Cell Reports 2018, 10: 1267\u20131281.","journal-title":"Stem Cell Reports"},{"key":"1584_CR103","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1016\/j.stemcr.2022.09.004","volume":"17","author":"SJ Mayerl","year":"2022","unstructured":"Mayerl SJ, Bajgai S, Ludwig AL, Jager LD, Williams BN, Bacig C, et al. Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa. Stem Cell Reports 2022, 17: 2409\u20132420.","journal-title":"Stem Cell Reports"},{"key":"1584_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.08.004","volume":"38","author":"J Wang","year":"2014","unstructured":"Wang J, Deretic D. Molecular complexes that direct rhodopsin transport to primary Cilia. Prog Retin Eye Res 2014, 38: 1\u201319.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR105","doi-asserted-by":"publisher","first-page":"e17084","DOI":"10.1371\/journal.pone.0017084","volume":"6","author":"ZB Jin","year":"2011","unstructured":"Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, et al. Modeling retinal degeneration using patient-specific induced pluripotent stem cells. PLoS One 2011, 6: e17084.","journal-title":"PLoS One"},{"key":"1584_CR106","doi-asserted-by":"publisher","first-page":"503","DOI":"10.5966\/sctm.2012-0005","volume":"1","author":"ZB Jin","year":"2012","unstructured":"Jin ZB, Okamoto S, Xiang P, Takahashi M. Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling. Stem Cells Transl Med 2012, 1: 503\u2013509.","journal-title":"Stem Cells Transl Med"},{"key":"1584_CR107","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","volume":"368","author":"DT Hartong","year":"2006","unstructured":"Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet 2006, 368: 1795\u20131809.","journal-title":"Lancet"},{"key":"1584_CR108","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1756-6606-7-45","volume":"7","author":"T Yoshida","year":"2014","unstructured":"Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, et al. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain 2014, 7: 45.","journal-title":"Mol Brain"},{"key":"1584_CR109","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1089\/zeb.2018.1613","volume":"15","author":"R Slijkerman","year":"2018","unstructured":"Slijkerman R, Goloborodko A, Broekman S, de Vrieze E, Hetterschijt L, Peters T, et al. Poor splice-site recognition in a humanized zebrafish knockin model for the recurrent deep-intronic c.7595-2144A>G mutation in USH2A. Zebrafish 2018, 15: 597\u2013609.","journal-title":"Zebrafish"},{"key":"1584_CR110","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1086\/383096","volume":"74","author":"E van Wijk","year":"2004","unstructured":"van Wijk E, Pennings RJE, te Brinke H, Claassen A, Yntema HG, Hoefsloot LH, et al. Identification of 51 novel exons of the Usher syndrome type 2A (USH2A) gene that encode multiple conserved functional domains and that are mutated in patients with Usher syndrome type II. Am J Hum Genet 2004, 74: 738\u2013744.","journal-title":"Am J Hum Genet"},{"key":"1584_CR111","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/humu.22926","volume":"37","author":"A Liquori","year":"2016","unstructured":"Liquori A, Vach\u00e9 C, Baux D, Blanchet C, Hamel C, Malcolm S, et al. Whole USH2A gene sequencing identifies several new deep intronic mutations. Hum Mutat 2016, 37: 184\u2013193.","journal-title":"Hum Mutat"},{"key":"1584_CR112","doi-asserted-by":"publisher","first-page":"36070","DOI":"10.1074\/jbc.M114.610535","volume":"289","author":"Q Chen","year":"2014","unstructured":"Chen Q, Zou J, Shen Z, Zhang W, Yang J. Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2. J Biol Chem 2014, 289: 36070\u201336088.","journal-title":"J Biol Chem"},{"key":"1584_CR113","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fncel.2019.00361","volume":"13","author":"Y Guo","year":"2019","unstructured":"Guo Y, Wang P, Ma JH, Cui Z, Yu Q, Liu S, et al. Modeling retinitis pigmentosa: Retinal organoids generated from the iPSCs of a patient with the USH2A mutation show early developmental abnormalities. Front Cell Neurosci 2019, 13: 361.","journal-title":"Front Cell Neurosci"},{"key":"1584_CR114","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.preteyeres.2008.05.003","volume":"27","author":"AI den Hollander","year":"2008","unstructured":"den Hollander AI, Roepman R, Koenekoop RK, Cremers FPM. Leber congenital amaurosis: Genes, proteins and disease mechanisms. Prog Retin Eye Res 2008, 27: 391\u2013419.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR115","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1167\/iovs.05-1637","volume":"47","author":"S Yzer","year":"2006","unstructured":"Yzer S, Fishman GA, Racine J, Al-Zuhaibi S, Chakor H, Dorfman A, et al. CRB1 heterozygotes with regional retinal dysfunction: Implications for genetic testing of leber congenital amaurosis. Invest Ophthalmol Vis Sci 2006, 47: 3736\u20133744.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR116","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/humu.20010","volume":"23","author":"S Hanein","year":"2004","unstructured":"Hanein S, Perrault I, Gerber S, Tanguy G, Barbet F, Ducroq D, et al. Leber congenital amaurosis: Comprehensive survey of the genetic heterogeneity, refinement of the clinical definition, and genotype-phenotype correlations as a strategy for molecular diagnosis. Hum Mutat 2004, 23: 306\u2013317.","journal-title":"Hum Mutat"},{"key":"1584_CR117","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.survophthal.2004.04.003","volume":"49","author":"RK Koenekoop","year":"2004","unstructured":"Koenekoop RK. An overview of Leber congenital amaurosis: A model to understand human retinal development. Surv Ophthalmol 2004, 49: 379\u2013398.","journal-title":"Surv Ophthalmol"},{"key":"1584_CR118","doi-asserted-by":"publisher","first-page":"13897","DOI":"10.1073\/pnas.0404197101","volume":"101","author":"V Ramamurthy","year":"2004","unstructured":"Ramamurthy V, Niemi GA, Reh TA, Hurley JB. Leber congenital amaurosis linked to AIPL1: A mouse model reveals destabilization of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 2004, 101: 13897\u201313902.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR119","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1093\/hmg\/ddl107","volume":"15","author":"B Chang","year":"2006","unstructured":"Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, et al. In-frame deletion in a novel centrosomal\/ciliary protein CEP290\/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet 2006, 15: 1847\u20131857.","journal-title":"Hum Mol Genet"},{"key":"1584_CR120","first-page":"152","volume":"11","author":"JJ Pang","year":"2005","unstructured":"Pang JJ, Chang B, Hawes NL, Hurd RE, Davisson MT, Li J, et al. Retinal degeneration 12 (rd12): A new, spontaneously arising mouse model for human leber congenital amaurosis (LCA). Mol Vis 2005, 11: 152\u2013162.","journal-title":"Mol Vis"},{"key":"1584_CR121","first-page":"3149","volume":"41","author":"NL Hawes","year":"2000","unstructured":"Hawes NL, Chang B, Hageman GS, Nusinowitz S, Nishina PM, Schneider BS, et al. Retinal degeneration 6 (rd6): A new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci 2000, 41: 3149\u20133157.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR122","doi-asserted-by":"publisher","first-page":"1291795","DOI":"10.3389\/fmed.2023.1291795","volume":"10","author":"Y Liu","year":"2024","unstructured":"Liu Y, Tai J, Yu C, Xu D, Xiao D, Pang J. Unlocking therapeutic potential: Dual gene therapy for ameliorating the disease phenotypes in a mouse model of RPE65 Leber congenital amaurosis. Front Med (Lausanne) 2024, 10: 1291795.","journal-title":"Front Med (Lausanne)"},{"key":"1584_CR123","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/iovs.64.14.10","volume":"64","author":"D Swinkels","year":"2023","unstructured":"Swinkels D, Kocherlakota S, Das Y, Dane AD, Wever EJM, Vaz FM, et al. DHA shortage causes the early degeneration of photoreceptors and RPE in mice with peroxisomal \u03b2-oxidation deficiency. Invest Ophthalmol Vis Sci 2023, 64: 10.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR124","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.cell.2018.03.021","volume":"173","author":"RS Apte","year":"2018","unstructured":"Apte RS. Gene therapy for retinal degeneration. Cell 2018, 173: 5.","journal-title":"Cell"},{"key":"1584_CR125","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fnmol.2019.00212","volume":"12","author":"G Li","year":"2019","unstructured":"Li G, Gao G, Wang P, Song X, Xu P, Xie B, et al. Generation and characterization of induced pluripotent stem cells and retinal organoids from a leber\u2019s congenital amaurosis patient with novel RPE65 mutations. Front Mol Neurosci 2019, 12: 212.","journal-title":"Front Mol Neurosci"},{"key":"1584_CR126","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/3813","volume":"20","author":"TM Redmond","year":"1998","unstructured":"Redmond TM, Yu S, Lee E, Bok D, Hamasaki D, Chen N, et al. Rpe65 is necessary for production of 11-Cis-vitamin A in the retinal visual cycle. Nat Genet 1998, 20: 344\u2013351.","journal-title":"Nat Genet"},{"key":"1584_CR127","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.stemcr.2023.03.014","volume":"18","author":"N Boon","year":"2023","unstructured":"Boon N, Lu X, Andriessen CA, Moustakas I, Buck TM, Freund C, et al. AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype. Stem Cell Reports 2023, 18: 1123\u20131137.","journal-title":"Stem Cell Reports"},{"key":"1584_CR128","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.stem.2016.03.021","volume":"18","author":"DA Parfitt","year":"2016","unstructured":"Parfitt DA, Lane A, Ramsden CM, Carr AF, Munro PM, Jovanovic K, et al. Identification and correction of mechanisms underlying inherited blindness in human iPSC-derived optic cups. Cell Stem Cell 2016, 18: 769\u2013781.","journal-title":"Cell Stem Cell"},{"key":"1584_CR129","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.celrep.2017.06.045","volume":"20","author":"H Shimada","year":"2017","unstructured":"Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, et al. In vitro modeling using ciliopathy-patient-derived cells reveals distinct Cilia dysfunctions caused by CEP290 mutations. Cell Rep 2017, 20: 384\u2013396.","journal-title":"Cell Rep"},{"key":"1584_CR130","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ajo.2019.11.012","volume":"211","author":"B Feldhaus","year":"2020","unstructured":"Feldhaus B, Weisschuh N, Nasser F, den Hollander AI, Cremers FPM, Zrenner E, et al. CEP290 mutation spectrum and delineation of the associated phenotype in a large German cohort: A monocentric study. Am J Ophthalmol 2020, 211: 142\u2013150.","journal-title":"Am J Ophthalmol"},{"key":"1584_CR131","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ajo.2024.06.013","volume":"266","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Sun J, Liu Z, Wang H, Zhou H, Liu W, et al. Clinical and molecular characterization of AIPL1-associated leber congenital amaurosis\/early-onset severe retinal dystrophy. Am J Ophthalmol 2024, 266: 235\u2013247.","journal-title":"Am J Ophthalmol"},{"key":"1584_CR132","doi-asserted-by":"publisher","first-page":"5912","DOI":"10.3390\/ijms24065912","volume":"24","author":"PRL Perdig\u00e3o","year":"2023","unstructured":"Perdig\u00e3o PRL, Ollington B, Sai H, Leung A, Sacristan-Reviriego A, van der Spuy J. Retinal organoids from an AIPL1 CRISPR\/Cas9 knockout cell line successfully recapitulate the molecular features of LCA4 disease. Int J Mol Sci 2023, 24: 5912.","journal-title":"Int J Mol Sci"},{"key":"1584_CR133","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","volume":"379","author":"LS Lim","year":"2012","unstructured":"Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet 2012, 379: 1728\u20131738.","journal-title":"Lancet"},{"key":"1584_CR134","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1056\/NEJMra0801537","volume":"358","author":"RD Jager","year":"2008","unstructured":"Jager RD, Mieler WF, Miller JW. Age-related macular degeneration. N Engl J Med 2008, 358: 2606\u20132617.","journal-title":"N Engl J Med"},{"key":"1584_CR135","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ajo.2020.05.029","volume":"218","author":"GC Brown","year":"2020","unstructured":"Brown GC, Brown MM, Rapuano S, Boyer D. Cost-utility analysis of VEGF inhibitors for treating neovascular age-related macular degeneration. Am J Ophthalmol 2020, 218: 225\u2013241.","journal-title":"Am J Ophthalmol"},{"key":"1584_CR136","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1167\/iovs.16-19238","volume":"57","author":"BB Thomas","year":"2016","unstructured":"Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, et al. Survival and functionality of hESC-derived retinal pigment epithelium cells cultured as a monolayer on polymer substrates transplanted in RCS rats. Invest Ophthalmol Vis Sci 2016, 57: 2877\u20132887.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR137","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10633-018-9648-8","volume":"137","author":"H Wu","year":"2018","unstructured":"Wu H, Li J, Mao X, Li G, Xie L, You Z. Transplantation of rat embryonic stem cell-derived retinal cells restores visual function in the Royal College of Surgeons rats. Doc Ophthalmol 2018, 137: 71\u201378.","journal-title":"Doc Ophthalmol"},{"key":"1584_CR138","doi-asserted-by":"publisher","first-page":"e688","DOI":"10.1111\/aos.14004","volume":"97","author":"T Ilmarinen","year":"2019","unstructured":"Ilmarinen T, Thieltges F, Hongisto H, Juuti-Uusitalo K, Koistinen A, Kaarniranta K, et al. Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits. Acta Ophthalmol 2019, 97: e688\u2013e699.","journal-title":"Acta Ophthalmol"},{"key":"1584_CR139","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.stemcr.2013.12.007","volume":"2","author":"H Kamao","year":"2014","unstructured":"Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Reports 2014, 2: 205\u2013218.","journal-title":"Stem Cell Reports"},{"key":"1584_CR140","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1080\/14712598.2017.1346079","volume":"17","author":"P Bracha","year":"2017","unstructured":"Bracha P, Moore NA, Ciulla TA. Induced pluripotent stem cell-based therapy for age-related macular degeneration. Expert Opin Biol Ther 2017, 17: 1113\u20131126.","journal-title":"Expert Opin Biol Ther"},{"key":"1584_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.004","volume":"48","author":"H Nazari","year":"2015","unstructured":"Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, et al. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res 2015, 48: 1\u201339.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR142","doi-asserted-by":"publisher","first-page":"6183","DOI":"10.1038\/s41467-022-33848-y","volume":"13","author":"M V\u00f6lkner","year":"2022","unstructured":"V\u00f6lkner M, Wagner F, Steinheuer LM, Carido M, Kurth T, Yazbeck A, et al. HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids. Nat Commun 2022, 13: 6183.","journal-title":"Nat Commun"},{"key":"1584_CR143","doi-asserted-by":"publisher","first-page":"101593","DOI":"10.1016\/j.gendis.2025.101593","volume":"12","author":"X Hao","year":"2025","unstructured":"Hao X, Du L, Liu G, Li Z, Wang S. Human retinal organoids for modelling dry age-related macular degeneration and screening drugs. Genes Dis 2025, 12: 101593.","journal-title":"Genes Dis"},{"key":"1584_CR144","doi-asserted-by":"crossref","unstructured":"Pinheiro L, Tsang SH, Sharma T. Stargardt disease. In: Atlas of Inherited Retinal Diseases. Springer Nature Switzerland, 2025: 151\u2013161.","DOI":"10.1007\/978-3-031-72230-1_27"},{"key":"1584_CR145","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/ng0397-236","volume":"15","author":"R Allikmets","year":"1997","unstructured":"Allikmets R, Singh N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 1997, 15: 236\u2013246.","journal-title":"Nat Genet"},{"key":"1584_CR146","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.preteyeres.2010.01.001","volume":"29","author":"V Vasireddy","year":"2010","unstructured":"Vasireddy V, Wong P, Ayyagari R. Genetics and molecular pathology of stargardt-like macular degeneration. Prog Retin Eye Res 2010, 29: 191\u2013207.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR147","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/bjophthalmol-2016-308823","volume":"101","author":"P Tanna","year":"2017","unstructured":"Tanna P, Strauss RW, Fujinami K, Michaelides M. Stargardt disease: Clinical features, molecular genetics, animal models and therapeutic options. Br J Ophthalmol 2017, 101: 25\u201330.","journal-title":"Br J Ophthalmol"},{"key":"1584_CR148","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1089\/hum.2019.132","volume":"30","author":"FM Dyka","year":"2019","unstructured":"Dyka FM, Molday LL, Chiodo VA, Molday RS, Hauswirth WW. Dual ABCA4-AAV vector treatment reduces pathogenic retinal A2E accumulation in a mouse model of autosomal recessive stargardt disease. Hum Gene Ther 2019, 30: 1361\u20131370.","journal-title":"Hum Gene Ther"},{"key":"1584_CR149","first-page":"2595","volume":"62","author":"Py Su","year":"2021","unstructured":"Su PY, Chuang JZ, Lee W, Zernant J, Tsang SH, Nagasaki T, et al. Characterization of Stargardt disease patient-derived human retinal organoids harboring the p. Gly1961Glu mutation in the ABCA4 gene. Invest Ophthalmol Vis Sci 2021, 62: 2595.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR150","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.omtn.2020.06.007","volume":"21","author":"M Khan","year":"2020","unstructured":"Khan M, Arno G, Fakin A, Parfitt DA, Dhooge PPA, Albert S, et al. Detailed phenotyping and therapeutic strategies for intronic ABCA4 variants in stargardt disease. Mol Ther Nucleic Acids 2020, 21: 412\u2013427.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1584_CR151","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41419-025-07420-7","volume":"16","author":"A Watson","year":"2025","unstructured":"Watson A, Queen R, Ferr\u00e1ndez-Peral L, Dorgau B, Collin J, Nelson A, et al. Unravelling genotype-phenotype correlations in Stargardt disease using patient-derived retinal organoids. Cell Death Dis 2025, 16: 108.","journal-title":"Cell Death Dis"},{"key":"1584_CR152","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ophtha.2021.11.019","volume":"129","author":"M Georgiou","year":"2022","unstructured":"Georgiou M, Finocchio L, Fujinami K, Fujinami-Yokokawa Y, Virgili G, Mahroo OA, et al. X-linked retinoschisis: Deep phenotyping and genetic characterization. Ophthalmology 2022, 129: 542\u2013551.","journal-title":"Ophthalmology"},{"key":"1584_CR153","doi-asserted-by":"publisher","first-page":"a041288","DOI":"10.1101\/cshperspect.a041288","volume":"13","author":"CA Ku","year":"2023","unstructured":"Ku CA, Wei LW, Sieving PA. X-linked retinoschisis. Cold Spring Harb Perspect Med 2023, 13: a041288.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1584_CR154","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.preteyeres.2011.12.002","volume":"31","author":"RS Molday","year":"2012","unstructured":"Molday RS, Kellner U, Weber BHF. X-linked juvenile retinoschisis: Clinical diagnosis, genetic analysis, and molecular mechanisms. Prog Retin Eye Res 2012, 31: 195\u2013212.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR155","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/bjo.2005.078048","volume":"90","author":"T Wang","year":"2006","unstructured":"Wang T, Zhou A, Waters CT, O\u2019Connor E, Read RJ, Trump D. Molecular pathology of X linked retinoschisis: Mutations interfere with retinoschisin secretion and oligomerisation. Br J Ophthalmol 2006, 90: 81\u201386.","journal-title":"Br J Ophthalmol"},{"key":"1584_CR156","doi-asserted-by":"publisher","first-page":"8203","DOI":"10.3390\/ijms25158203","volume":"25","author":"JW Han","year":"2024","unstructured":"Han JW, Chang HS, Park SC, Yang JY, Kim YJ, Kim JH, et al. Early developmental characteristics and features of a three-dimensional retinal organoid model of X-linked juvenile retinoschisis. Int J Mol Sci 2024, 25: 8203.","journal-title":"Int J Mol Sci"},{"key":"1584_CR157","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13287-024-03767-4","volume":"15","author":"C Duan","year":"2024","unstructured":"Duan C, Ding C, Sun X, Mao S, Liang Y, Liu X, et al. Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy. Stem Cell Res Ther 2024, 15: 152.","journal-title":"Stem Cell Res Ther"},{"key":"1584_CR158","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.stemcr.2023.07.001","volume":"18","author":"TM Buck","year":"2023","unstructured":"Buck TM, Quinn PMJ, Pellissier LP, Mulder AA, Jongejan A, Lu X, et al. CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids. Stem Cell Reports 2023, 18: 1793\u20131810.","journal-title":"Stem Cell Reports"},{"key":"1584_CR159","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1167\/iovs.17-23646","volume":"59","author":"BT McLelland","year":"2018","unstructured":"McLelland BT, Lin B, Mathur A, Aramant RB, Thomas BB, Nistor G, et al. Transplanted hESC-derived retina organoid sheets differentiate, integrate, and improve visual function in retinal degenerate rats. Invest Ophthalmol Vis Sci 2018, 59: 2586\u20132603.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR160","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.reth.2022.12.005","volume":"22","author":"M Mandai","year":"2023","unstructured":"Mandai M. Pluripotent stem cell-derived retinal organoid\/cells for retinal regeneration therapies: A review. Regen Ther 2023, 22: 59\u201367.","journal-title":"Regen Ther"},{"key":"1584_CR161","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.stemcr.2017.04.030","volume":"8","author":"K Kruczek","year":"2017","unstructured":"Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, et al. Differentiation and transplantation of embryonic stem cell-derived cone photoreceptors into a mouse model of end-stage retinal degeneration. Stem Cell Reports 2017, 8: 1659\u20131674.","journal-title":"Stem Cell Reports"},{"key":"1584_CR162","doi-asserted-by":"publisher","first-page":"e154619","DOI":"10.1172\/JCI154619","volume":"132","author":"SJ Gasparini","year":"2022","unstructured":"Gasparini SJ, Tessmer K, Reh M, Wieneke S, Carido M, V\u00f6lkner M, et al. Transplanted human cones incorporate into the retina and function in a murine cone degeneration model. J Clin Invest 2022, 132: e154619.","journal-title":"J Clin Invest"},{"key":"1584_CR163","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s13287-016-0451-8","volume":"7","author":"X Chen","year":"2016","unstructured":"Chen X, Chen Z, Li Z, Zhao C, Zeng Y, Zou T, et al. Grafted c-kit+\/SSEA1- eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses. Stem Cell Res Ther 2016, 7: 191.","journal-title":"Stem Cell Res Ther"},{"key":"1584_CR164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.11.001","volume":"69","author":"SJ Gasparini","year":"2019","unstructured":"Gasparini SJ, Llonch S, Borsch O, Ader M. Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives. Prog Retin Eye Res 2019, 69: 1\u201337.","journal-title":"Prog Retin Eye Res"},{"key":"1584_CR165","doi-asserted-by":"publisher","first-page":"6864","DOI":"10.1126\/scitranslmed.adp6864","volume":"17","author":"H Liu","year":"2025","unstructured":"Liu H, Ma Y, Gao N, Zhou Y, Li G, Zhu Q, et al. Identification and characterization of human retinal stem cells capable of retinal regeneration. Sci Transl Med 2025, 17: 6864.","journal-title":"Sci Transl Med"},{"key":"1584_CR166","doi-asserted-by":"publisher","first-page":"13029","DOI":"10.1038\/ncomms13029","volume":"7","author":"RA Pearson","year":"2016","unstructured":"Pearson RA, Gonzalez-Cordero A, West EL, Ribeiro JR, Aghaizu N, Goh D, et al. Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors. Nat Commun 2016, 7: 13029.","journal-title":"Nat Commun"},{"key":"1584_CR167","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/stem.2552","volume":"35","author":"A Ortin-Martinez","year":"2017","unstructured":"Ortin-Martinez A, Tsai ELS, Nickerson PE, Bergeret M, Lu Y, Smiley S, et al. A reinterpretation of cell transplantation: GFP transfer from donor to host photoreceptors. Stem Cells 2017, 35: 932\u2013939.","journal-title":"Stem Cells"},{"key":"1584_CR168","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.stemcr.2017.12.008","volume":"10","author":"PV Waldron","year":"2018","unstructured":"Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, et al. Transplanted donor- or stem cell-derived cone photoreceptors can both integrate and undergo material transfer in an environment-dependent manner. Stem Cell Reports 2018, 10: 406\u2013421.","journal-title":"Stem Cell Reports"},{"key":"1584_CR169","doi-asserted-by":"publisher","first-page":"13028","DOI":"10.1038\/ncomms13028","volume":"7","author":"T Santos-Ferreira","year":"2016","unstructured":"Santos-Ferreira T, Llonch S, Borsch O, Postel K, Haas J, Ader M. Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange. Nat Commun 2016, 7: 13028.","journal-title":"Nat Commun"},{"key":"1584_CR170","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13287-024-03679-3","volume":"15","author":"MT Ho","year":"2024","unstructured":"Ho MT, Kawai K, Abdo D, Comanita L, Ortin-Martinez A, Ueno Y, et al. Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina. Stem Cell Res Ther 2024, 15: 79.","journal-title":"Stem Cell Res Ther"},{"key":"1584_CR171","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.actbio.2021.07.040","volume":"134","author":"Z Luo","year":"2021","unstructured":"Luo Z, Xian B, Li K, Li K, Yang R, Chen M, et al. Biodegradable scaffolds facilitate epiretinal transplantation of hiPSC-Derived retinal neurons in nonhuman Primates. Acta Biomater 2021, 134: 289\u2013301.","journal-title":"Acta Biomater"},{"key":"1584_CR172","doi-asserted-by":"publisher","first-page":"585675","DOI":"10.3389\/fcell.2020.585675","volume":"8","author":"O Rabesandratana","year":"2020","unstructured":"Rabesandratana O, Chaffiol A, Mialot A, Slembrouck-Brec A, Joffrois C, Nanteau C, et al. Generation of a transplantable population of human iPSC-derived retinal ganglion cells. Front Cell Dev Biol 2020, 8: 585675.","journal-title":"Front Cell Dev Biol"},{"key":"1584_CR173","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.omtm.2021.03.004","volume":"21","author":"J Oswald","year":"2021","unstructured":"Oswald J, Kegeles E, Minelli T, Volchkov P, Baranov P. Transplantation of miPSC\/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas. Mol Ther Methods Clin Dev 2021, 21: 180\u2013198.","journal-title":"Mol Ther Methods Clin Dev"},{"key":"1584_CR174","doi-asserted-by":"publisher","first-page":"c1","DOI":"10.1167\/iovs.15-18681","volume":"57","author":"SD Schwartz","year":"2016","unstructured":"Schwartz SD, Tan G, Hosseini H, Nagiel A. Subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium for the treatment of macular degeneration: An assessment at 4 years. Invest Ophthalmol Vis Sci 2016, 57: c1\u2013c9.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1584_CR175","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/j.ophtha.2018.04.037","volume":"125","author":"MS Mehat","year":"2018","unstructured":"Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, et al. Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmology 2018, 125: 1765\u20131775.","journal-title":"Ophthalmology"},{"key":"1584_CR176","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/tvst.10.10.13","volume":"10","author":"AH Kashani","year":"2021","unstructured":"Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Chen S, et al. One-year follow-up in a phase 1\/2a clinical trial of an allogeneic RPE cell bioengineered implant for advanced dry age-related macular degeneration. Transl Vis Sci Technol 2021, 10: 13.","journal-title":"Transl Vis Sci Technol"},{"key":"1584_CR177","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuint.2008.10.014","volume":"54","author":"A Bringmann","year":"2009","unstructured":"Bringmann A, Pannicke T, Biedermann B, Francke M, Iandiev I, Grosche J, et al. Role of retinal glial cells in neurotransmitter uptake and metabolism. Neurochem Int 2009, 54: 143\u2013160.","journal-title":"Neurochem Int"},{"key":"1584_CR178","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.1523\/JNEUROSCI.0442-12.2012","volume":"32","author":"S Sonntag","year":"2012","unstructured":"Sonntag S, Dedek K, Dorgau B, Schultz K, Schmidt KF, Cimiotti K, et al. Ablation of retinal horizontal cells from adult mice leads to rod degeneration and remodeling in the outer retina. J Neurosci 2012, 32: 10713\u201310724.","journal-title":"J Neurosci"},{"key":"1584_CR179","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3389\/fncel.2019.00423","volume":"13","author":"L Nemitz","year":"2019","unstructured":"Nemitz L, Dedek K, Janssen-Bienhold U. Rod bipolar cells require horizontal cells for invagination into the terminals of rod photoreceptors. Front Cell Neurosci 2019, 13: 423.","journal-title":"Front Cell Neurosci"},{"key":"1584_CR180","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.stemcr.2018.01.032","volume":"10","author":"S Iraha","year":"2018","unstructured":"Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, et al. Establishment of immunodeficient retinal degeneration model mice and functional maturation of human ESC-derived retinal sheets after transplantation. Stem Cell Reports 2018, 10: 1059\u20131074.","journal-title":"Stem Cell Reports"},{"key":"1584_CR181","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.ebiom.2018.11.028","volume":"39","author":"HY Tu","year":"2019","unstructured":"Tu HY, Watanabe T, Shirai H, Yamasaki S, Kinoshita M, Matsushita K, et al. Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration. EBioMedicine 2019, 39: 562\u2013574.","journal-title":"EBioMedicine"},{"key":"1584_CR182","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1006\/exnr.1998.6992","volume":"157","author":"T Das","year":"1999","unstructured":"Das T, del Cerro M, Jalali S, Rao VS, Gullapalli VK, Little C, et al. The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: Results of a long-term safety study. Exp Neurol 1999, 157: 58\u201368.","journal-title":"Exp Neurol"},{"key":"1584_CR183","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ajo.2008.04.009","volume":"146","author":"ND Radtke","year":"2008","unstructured":"Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol 2008, 146: 172\u2013182.","journal-title":"Am J Ophthalmol"},{"key":"1584_CR184","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s42003-023-04543-5","volume":"6","author":"K Watari","year":"2023","unstructured":"Watari K, Yamasaki S, Tu HY, Shikamura M, Kamei T, Adachi H, et al. Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy. Commun Biol 2023, 6: 164.","journal-title":"Commun Biol"},{"key":"1584_CR185","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.stemcr.2016.08.010","volume":"7","author":"S Sugita","year":"2016","unstructured":"Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, et al. Successful transplantation of retinal pigment epithelial cells from MHC homozygote iPSCs in MHC-matched models. Stem Cell Reports 2016, 7: 635\u2013648.","journal-title":"Stem Cell Reports"},{"key":"1584_CR186","doi-asserted-by":"publisher","first-page":"204173142110598","DOI":"10.1177\/20417314211059876","volume":"12","author":"LF Marcos","year":"2021","unstructured":"Marcos LF, Wilson SL, Roach P. Tissue engineering of the retina: From organoids to microfluidic chips. J Tissue Eng 2021, 12: 20417314211059876.","journal-title":"J Tissue Eng"},{"key":"1584_CR187","doi-asserted-by":"publisher","first-page":"e46188","DOI":"10.7554\/eLife.46188","volume":"8","author":"K Achberger","year":"2019","unstructured":"Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, et al. Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform. Elife 2019, 8: e46188.","journal-title":"Elife"},{"key":"1584_CR188","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41592-022-01701-1","volume":"20","author":"MJ Song","year":"2023","unstructured":"Song MJ, Quinn R, Nguyen E, Hampton C, Sharma R, Park TS, et al. Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration. Nat Methods 2023, 20: 149\u2013161.","journal-title":"Nat Methods"},{"key":"1584_CR189","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/jop.2018.0140","volume":"36","author":"DM Aasen","year":"2020","unstructured":"Aasen DM, Vergara MN. New drug discovery paradigms for retinal diseases: A focus on retinal organoids. J Ocul Pharmacol Ther 2020, 36: 18\u201324.","journal-title":"J Ocul Pharmacol Ther"},{"key":"1584_CR190","doi-asserted-by":"publisher","first-page":"33628","DOI":"10.1073\/pnas.2011780117","volume":"117","author":"H Liu","year":"2020","unstructured":"Liu H, Zhang Y, Zhang YY, Li YP, Hua ZQ, Zhang CJ, et al. Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin. Proc Natl Acad Sci U S A 2020, 117: 33628\u201333638.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1584_CR191","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13046-023-02608-1","volume":"42","author":"A Srimongkol","year":"2023","unstructured":"Srimongkol A, Laosillapacharoen N, Saengwimol D, Chaitankar V, Rojanaporn D, Thanomchard T, et al. Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids. J Exp Clin Cancer Res 2023, 42: 39.","journal-title":"J Exp Clin Cancer Res"},{"key":"1584_CR192","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/stcltm\/szab010","volume":"11","author":"B Dorgau","year":"2022","unstructured":"Dorgau B, Georgiou M, Chaudhary A, Moya-Molina M, Collin J, Queen R, et al. Human retinal organoids provide a suitable tool for toxicological investigations: A comprehensive validation using drugs and compounds affecting the retina. Stem Cells Transl Med 2022, 11: 159\u2013177.","journal-title":"Stem Cells Transl Med"},{"key":"1584_CR193","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/stem.2883","volume":"36","author":"D Hallam","year":"2018","unstructured":"Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, et al. Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency. Stem Cells 2018, 36: 1535\u20131551.","journal-title":"Stem Cells"},{"key":"1584_CR194","first-page":"e62269","volume":"169","author":"K Eade","year":"2021","unstructured":"Eade K, Giles S, Harkins-Perry S, Friedlander M. Toxicity screens in human retinal organoids for pharmaceutical discovery. J Vis Exp 2021, 169: e62269.","journal-title":"J Vis Exp"},{"key":"1584_CR195","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13619-021-00097-1","volume":"10","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wang W, Jin ZB. Retinal organoids as models for development and diseases. Cell Regen 2021, 10: 33.","journal-title":"Cell Regen"},{"key":"1584_CR196","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.stemcr.2020.05.007","volume":"15","author":"A Lane","year":"2020","unstructured":"Lane A, Jovanovic K, Shortall C, Ottaviani D, Panes AB, Schwarz N, et al. Modeling and rescue of RP2 retinitis pigmentosa using iPSC-derived retinal organoids. Stem Cell Reports 2020, 15: 67\u201379.","journal-title":"Stem Cell Reports"},{"key":"1584_CR197","doi-asserted-by":"publisher","first-page":"102148","DOI":"10.1016\/j.omtn.2024.102148","volume":"35","author":"H Sai","year":"2024","unstructured":"Sai H, Ollington B, Rezek FO, Chai N, Lane A, Georgiadis T, et al. Effective AAV-mediated gene replacement therapy in retinal organoids modeling AIPL1-associated LCA4. Mol Ther Nucleic Acids 2024, 35: 102148.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1584_CR198","doi-asserted-by":"publisher","first-page":"101128","DOI":"10.1016\/j.omtm.2023.101128","volume":"31","author":"N Boon","year":"2023","unstructured":"Boon N, Lu X, Andriessen CA, Orlov\u00e0 M, Quinn PMJ, Boon CJF, et al. Characterization and AAV-mediated CRB gene augmentation in human-derived CRB1KO and CRB1KOCRB2+ \/- retinal organoids. Mol Ther Methods Clin Dev 2023, 31: 101128.","journal-title":"Mol Ther Methods Clin Dev"},{"key":"1584_CR199","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.11.4.3","volume":"11","author":"ME McClements","year":"2022","unstructured":"McClements ME, Steward H, Atkin W, Goode EA, G\u00e1ndara C, Chichagova V, et al. Tropism of AAV vectors in photoreceptor-like cells of human iPSC-derived retinal organoids. Transl Vis Sci Technol 2022, 11: 3.","journal-title":"Transl Vis Sci Technol"},{"key":"1584_CR200","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1444-0938.2005.tb06711.x","volume":"88","author":"JM Provis","year":"2005","unstructured":"Provis JM, Penfold PL, Cornish EE, Sandercoe TM, Madigan MC. Anatomy and development of the macula: Specialisation and the vulnerability to macular degeneration. Clin Exp Optom 2005, 88: 269\u2013281.","journal-title":"Clin Exp Optom"},{"key":"1584_CR201","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.3390\/cells9081759","volume":"9","author":"X Pereiro","year":"2020","unstructured":"Pereiro X, Miltner AM, La Torre A, Vecino E. Effects of adult M\u00fcller cells and their conditioned media on the survival of stem cell-derived retinal ganglion cells. Cells 2020, 9: 1759.","journal-title":"Cells"},{"key":"1584_CR202","first-page":"093","volume":"43","author":"S Inagaki","year":"2025","unstructured":"Inagaki S, Nakamura S, Kuse Y, Aoshima K, Funato M, Shimazawa M, et al. Establishment of vascularized human retinal organoids from induced pluripotent stem cells. Stem Cells 2025, 43: 093.","journal-title":"Stem Cells"},{"key":"1584_CR203","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1146\/annurev-bioeng-090120-094330","volume":"23","author":"VS Shirure","year":"2021","unstructured":"Shirure VS, Hughes CCW, George SC. Engineering vascularized organoid-on-a-chip models. Annu Rev Biomed Eng 2021, 23: 141\u2013167.","journal-title":"Annu Rev Biomed Eng"},{"key":"1584_CR204","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1161\/CIRCRESAHA.122.321768","volume":"132","author":"K Salewskij","year":"2023","unstructured":"Salewskij K, Penninger JM. Blood vessel organoids for development and disease. Circ Res 2023, 132: 498\u2013510.","journal-title":"Circ Res"},{"key":"1584_CR205","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.1126\/sciadv.ady6410","volume":"11","author":"H Chen","year":"2025","unstructured":"Chen H, Liang Y, Sun X, Xiong W, Yang T, Liang Y, et al. Generation of vascularized retinal organoids containing microglia based on a PDMS microwell platform. Sci Adv 2025, 11: 6410.","journal-title":"Sci Adv"},{"key":"1584_CR206","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1002\/glia.24428","volume":"71","author":"A Usui-Ouchi","year":"2023","unstructured":"Usui-Ouchi A, Giles S, Harkins-Perry S, Mills EA, Bonelli R, Wei G, et al. Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche. Glia 2023, 71: 2372\u20132382.","journal-title":"Glia"},{"key":"1584_CR207","doi-asserted-by":"publisher","first-page":"110417","DOI":"10.1016\/j.exer.2025.110417","volume":"256","author":"Y Chen","year":"2025","unstructured":"Chen Y, Xu H, Xiao L, Zhang M, Yan N. Single-cell RNA sequencing in the study of human retinal organoids. Exp Eye Res 2025, 256: 110417.","journal-title":"Exp Eye Res"},{"key":"1584_CR208","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/stem.2963","volume":"37","author":"J Collin","year":"2019","unstructured":"Collin J, Queen R, Zerti D, Dorgau B, Hussain R, Coxhead J, et al. Deconstructing retinal organoids: Single cell RNA-seq reveals the cellular components of human pluripotent stem cell-derived retina. Stem Cells 2019, 37: 593\u2013598.","journal-title":"Stem Cells"},{"key":"1584_CR209","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1039\/D1LC00011J","volume":"21","author":"Y Xue","year":"2021","unstructured":"Xue Y, Seiler MJ, Tang WC, Wang JY, Delgado J, McLelland BT, et al. Retinal organoids on-a-chip: A micro-millifluidic bioreactor for long-term organoid maintenance. Lab Chip 2021, 21: 3361\u20133377.","journal-title":"Lab Chip"},{"key":"1584_CR210","doi-asserted-by":"publisher","first-page":"035005","DOI":"10.1088\/1758-5090\/acc761","volume":"15","author":"X Sun","year":"2023","unstructured":"Sun X, Cui Z, Liang Y, Duan C, Chan HF, Mao S, et al. One-stop assembly of adherent 3D retinal organoids from hiPSCs based on 3D-printed derived PDMS microwell platform. Biofabrication 2023, 15: 035005.","journal-title":"Biofabrication"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01584-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-025-01584-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-025-01584-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:28:40Z","timestamp":1778473720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-025-01584-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":210,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1584"],"URL":"https:\/\/doi.org\/10.1007\/s12264-025-01584-0","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"20 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors confirm that all necessary permissions have been obtained, including the BioRender Academic Publication License for scientific illustration use.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}