{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:24Z","timestamp":1791895584174,"version":"4.3.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s12264-026-01616-3","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:45:13Z","timestamp":1775756713000},"page":"2010-2024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Fgr-STAT3 Mediated Autophagy Inhibition in the Spinal Cord Alleviates Neuropathic Pain in Rats"],"prefix":"10.1007","volume":"42","author":[{"given":"Liqiong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malijiang","family":"Mulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qulian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-1865","authenticated-orcid":false,"given":"Changsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"1616_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1152\/physrev.00045.2019","volume":"101","author":"NB Finnerup","year":"2021","unstructured":"Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: From mechanisms to treatment. Physiol Rev 2021, 101: 259\u2013301.","journal-title":"Physiol Rev"},{"key":"1616_CR2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","volume":"131","author":"N Attal","year":"2023","unstructured":"Attal N, Bouhassira D, Colvin L. Advances and challenges in neuropathic pain: A narrative review and future directions. Br J Anaesth 2023, 131: 79\u201392.","journal-title":"Br J Anaesth"},{"key":"1616_CR3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nrn.2018.2","volume":"19","author":"K Inoue","year":"2018","unstructured":"Inoue K, Tsuda M. Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 2018, 19: 138\u2013152.","journal-title":"Nat Rev Neurosci"},{"key":"1616_CR4","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1007\/s12264-025-01533-x","volume":"41","author":"H Liu","year":"2025","unstructured":"Liu H, Yi L, Li G, Wang K, Wang H, Zhang Y. Fibroblast growth factor 8 suppresses neurotoxic astrocytes and alleviates neuropathic pain via spinal FGFR3 signaling. Neurosci Bull 2025, 41: 2218\u20132232.","journal-title":"Neurosci Bull"},{"key":"1616_CR5","doi-asserted-by":"crossref","unstructured":"Chu J, Yang J, Zhou Y, Chen J, Chen KH, Zhang C, et al. ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain. Sci Adv 2023, 9: eade9931.","DOI":"10.1126\/sciadv.ade9931"},{"key":"1616_CR6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI161507","volume":"133","author":"X Hu","year":"2023","unstructured":"Hu X, Du L, Liu S, Lan Z, Zang K, Feng J, et al. A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain. J Clin Invest 2023, 133: e161507.","journal-title":"J Clin Invest"},{"key":"1616_CR7","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMra2022774","volume":"383","author":"N Mizushima","year":"2020","unstructured":"Mizushima N, Levine B. Autophagy in human diseases. N Engl J Med 2020, 383: 1564\u20131576.","journal-title":"N Engl J Med"},{"key":"1616_CR8","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s12264-024-01183-5","volume":"40","author":"X Ai","year":"2024","unstructured":"Ai X, Yu H, Cai Y, Guan Y. Interactions between extracellular vesicles and autophagy in neuroimmune disorders. Neurosci Bull 2024, 40: 992\u20131006.","journal-title":"Neurosci Bull"},{"key":"1616_CR9","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1080\/15548627.2024.2330038","volume":"20","author":"S Fu","year":"2024","unstructured":"Fu S, Sun H, Wang J, Gao S, Zhu L, Cui K, et al. Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. Autophagy 2024, 20: 1559\u20131576.","journal-title":"Autophagy"},{"key":"1616_CR10","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1080\/15548627.2021.1900498","volume":"17","author":"J Li","year":"2021","unstructured":"Li J, Tian M, Hua T, Wang H, Yang M, Li W, et al. Combination of autophagy and NFE2L2\/NRF2 activation as a treatment approach for neuropathic pain. Autophagy 2021, 17: 4062\u20134082.","journal-title":"Autophagy"},{"key":"1616_CR11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221010","volume":"220","author":"K Futosi","year":"2023","unstructured":"Futosi K, N\u00e9meth T, Horv\u00e1th \u00c1I, Abram CL, Tusn\u00e1dy S, Lowell CA, et al. Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models. J Exp Med 2023, 220: e20221010.","journal-title":"J Exp Med"},{"key":"1616_CR12","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1186\/s12967-023-04345-7","volume":"21","author":"Y Liu","year":"2023","unstructured":"Liu Y, Yang H, Luo N, Fu Y, Qiu F, Pan Z, et al. An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1\/PGC-1\u03b1 signaling pathway. J Transl Med 2023, 21: 486.","journal-title":"J Transl Med"},{"key":"1616_CR13","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139987","volume":"5","author":"T Huang","year":"2020","unstructured":"Huang T, Fu G, Gao J, Zhang Y, Cai W, Wu S, et al. Fgr contributes to hemorrhage-induced thalamic pain by activating NF-\u03baB\/ERK1\/2 pathways. JCI Insight 2020, 5: e139987.","journal-title":"JCI Insight"},{"key":"1616_CR14","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1038\/s41467-020-19028-w","volume":"11","author":"MY Li","year":"2020","unstructured":"Li MY, Naik TS, Siu LYL, Acuto O, Spooner E, Wang P, et al. Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. Nat Commun 2020, 11: 5189.","journal-title":"Nat Commun"},{"key":"1616_CR15","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1038\/s41467-023-40086-3","volume":"14","author":"M Chen","year":"2023","unstructured":"Chen M, Menon MC, Wang W, Fu J, Yi Z, Sun Z, et al. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nat Commun 2023, 14: 4297.","journal-title":"Nat Commun"},{"key":"1616_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113549","volume":"153","author":"J Park","year":"2022","unstructured":"Park J, Kim Y, Lee C, Kim YT. 3, 5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3\/JAK2\/STAT3 signaling. Biomed Pharmacother 2022, 153: 113549.","journal-title":"Biomed Pharmacother"},{"key":"1616_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13045-018-0618-0","volume":"11","author":"H Li","year":"2018","unstructured":"Li H, Chen L, Li JJ, Zhou Q, Huang A, Liu WW, et al. miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3\/Bcl2 signaling pathway. J Hematol Oncol 2018, 11: 70.","journal-title":"J Hematol Oncol"},{"key":"1616_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41419-020-2467-3","volume":"11","author":"F Hu","year":"2020","unstructured":"Hu F, Li G, Huang C, Hou Z, Yang X, Luo X, et al. The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation. Cell Death Dis 2020, 11: 304.","journal-title":"Cell Death Dis"},{"key":"1616_CR19","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1080\/15548627.2015.1017192","volume":"11","author":"L You","year":"2015","unstructured":"You L, Wang Z, Li H, Shou J, Jing Z, Xie J, et al. The role of STAT3 in autophagy. Autophagy 2015, 11: 729\u2013739.","journal-title":"Autophagy"},{"key":"1616_CR20","doi-asserted-by":"publisher","first-page":"45680","DOI":"10.1074\/jbc.M204255200","volume":"277","author":"SJ Schreiner","year":"2002","unstructured":"Schreiner SJ, Schiavone AP, Smithgall TE. Activation of STAT3 by the src family kinase hck requires a functional SH3 domain. J Biol Chem 2002, 277: 45680\u201345687.","journal-title":"J Biol Chem"},{"key":"1616_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33: 87\u2013107.","journal-title":"Pain"},{"key":"1616_CR22","doi-asserted-by":"publisher","first-page":"2302916","DOI":"10.1002\/advs.202302916","volume":"11","author":"L He","year":"2024","unstructured":"He L, Ma S, Ding Z, Huang Z, Zhang Y, Xi C, et al. Inhibition of NFAT5-dependent astrocyte swelling alleviates neuropathic pain. Adv Sci 2024, 11: 2302916.","journal-title":"Adv Sci"},{"key":"1616_CR23","doi-asserted-by":"publisher","unstructured":"Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL. Simple and highly specific targeting of resident microglia with adeno-associated virus. bioRxiv 2023. https:\/\/doi.org\/10.1101\/2023.12.12.571321.","DOI":"10.1101\/2023.12.12.571321"},{"key":"1616_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/jnc.14883","volume":"152","author":"Y Shen","year":"2020","unstructured":"Shen Y, Ding Z, Ma S, Zou Y, Yang X, Ding Z, et al. Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. J Neurochem 2020, 152: 72\u201391.","journal-title":"J Neurochem"},{"key":"1616_CR25","first-page":"25","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000, 25: 25\u201329.","journal-title":"The Gene Ontology Consortium. Nat Genet"},{"key":"1616_CR26","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K. KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 2017, 45: D353\u2013D361.","journal-title":"Nucleic Acids Res"},{"key":"1616_CR27","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.3390\/ijms23052685","volume":"23","author":"MF Liao","year":"2022","unstructured":"Liao MF, Lu KT, Hsu JL, Lee CH, Cheng MY, Ro LS. The role of autophagy and apoptosis in neuropathic pain formation. Int J Mol Sci 2022, 23: 2685.","journal-title":"Int J Mol Sci"},{"key":"1616_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12974-025-03400-y","volume":"22","author":"Z Chi","year":"2025","unstructured":"Chi Z, Lu B, Liu R, Pan C, Meng B, Xing X, et al. Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis. J Neuroinflammation 2025, 22: 74.","journal-title":"J Neuroinflammation"},{"key":"1616_CR29","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12974-024-03049-z","volume":"21","author":"N Yu","year":"2024","unstructured":"Yu N, Cui H, Jin S, Liu P, Fang Y, Sun F, et al. IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve. J Neuroinflammation 2024, 21: 60.","journal-title":"J Neuroinflammation"},{"key":"1616_CR30","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","volume":"110","author":"A Fleming","year":"2022","unstructured":"Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, et al. The different autophagy degradation pathways and neurodegeneration. Neuron 2022, 110: 935\u2013966.","journal-title":"Neuron"},{"key":"1616_CR31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","volume":"54","author":"V Deretic","year":"2021","unstructured":"Deretic V. Autophagy in inflammation, infection, and immunometabolism. Immunity 2021, 54: 437\u2013453.","journal-title":"Immunity"},{"key":"1616_CR32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12974-021-02178-z","volume":"18","author":"S Shao","year":"2021","unstructured":"Shao S, Xu CB, Chen CJ, Shi GN, Guo QL, Zhou Y, et al. Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice. J Neuroinflammation 2021, 18: 142.","journal-title":"J Neuroinflammation"},{"key":"1616_CR33","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s12951-022-01522-6","volume":"20","author":"T Hua","year":"2022","unstructured":"Hua T, Yang M, Song H, Kong E, Deng M, Li Y, et al. Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p\/TRAF6 axis. J Nanobiotechnology 2022, 20: 324.","journal-title":"J Nanobiotechnology"},{"key":"1616_CR34","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s42255-020-00273-8","volume":"2","author":"R Ac\u00edn-P\u00e9rez","year":"2020","unstructured":"Ac\u00edn-P\u00e9rez R, Iborra S, Mart\u00ed-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, et al. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab 2020, 2: 974\u2013988.","journal-title":"Nat Metab"},{"key":"1616_CR35","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12974-022-02503-0","volume":"19","author":"YT Zhao","year":"2022","unstructured":"Zhao YT, Deng J, Liu HM, Wei JY, Fan HT, Liu M, et al. Adaptation of prelimbic cortex mediated by IL-6\/STAT3\/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats. J Neuroinflammation 2022, 19: 144.","journal-title":"J Neuroinflammation"},{"key":"1616_CR36","doi-asserted-by":"crossref","unstructured":"Ding HH, Zhang SB, Lv YY, Ma C, Liu M, Zhang KB, et al. TNF-\u03b1\/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT. J Neuroinflammation 2019, 16: 29.","DOI":"10.1186\/s12974-019-1421-8"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-026-01616-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-026-01616-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-026-01616-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:47:39Z","timestamp":1788508059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-026-01616-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1616"],"URL":"https:\/\/doi.org\/10.1007\/s12264-026-01616-3","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"13 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}}]}}