{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:06:23Z","timestamp":1789207583675,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"DOI":"10.1007\/s12264-026-01721-3","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:10:13Z","timestamp":1789204213000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vagal PIEZO2-Positive Neurons Mediate Blood Volume Sensing and Circulatory Homeostasis Regulation"],"prefix":"10.1007","author":[{"given":"Xingying","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-9101","authenticated-orcid":false,"given":"Han","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"1721_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41583-021-00544-7","volume":"23","author":"M Kim","year":"2022","unstructured":"Kim M, Heo G, Kim SY. Neural signalling of gut mechanosensation in ingestive and digestive processes. Nat Rev Neurosci 2022, 23: 135\u2013156.","journal-title":"Nat Rev Neurosci"},{"key":"1721_CR2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41586-020-2830-7","volume":"588","author":"KL Marshall","year":"2020","unstructured":"Marshall KL, Saade D, Ghitani N, Coombs AM, Szczot M, Keller J. PIEZO2 in sensory neurons and urothelial cells coordinates urination. Nature 2020, 588: 290\u2013295.","journal-title":"Nature"},{"key":"1721_CR3","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1007\/s12264-025-01384-6","volume":"41","author":"H Liu","year":"2025","unstructured":"Liu H, Huang X, Xia R, Zhao X, Li Z, Liu Q, et al. Comprehensive brain-wide mapping of afferent and efferent nuclei associated with the heart in the mouse. Neurosci Bull 2025, 41: 1743\u20131760.","journal-title":"Neurosci Bull"},{"key":"1721_CR4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1023\/A:1025080314925","volume":"23","author":"RAL Dampney","year":"2003","unstructured":"Dampney RAL, Polson JW, Potts PD, Hirooka Y, Horiuchi J. Functional organization of brain pathways subserving the baroreceptor reflex: Studies in conscious animals using immediate early gene expression. Cell Mol Neurobiol 2003, 23: 597\u2013616.","journal-title":"Cell Mol Neurobiol"},{"key":"1721_CR5","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1007\/s00415-012-6736-7","volume":"260","author":"M Metzler","year":"2013","unstructured":"Metzler M, Duerr S, Granata R, Krismer F, Robertson D, Wenning GK. Neurogenic orthostatic hypotension: Pathophysiology, evaluation, and management. J Neurol 2013, 260: 2212\u20132219.","journal-title":"J Neurol"},{"key":"1721_CR6","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/s41586-025-10010-4","volume":"651","author":"Z Liu","year":"2026","unstructured":"Liu Z, Lu S, Haskell IA, Schappe MS, Josipovi\u0107 M, Min S, et al. Vagal blood volume receptors compensate for haemorrhage and posture change. Nature 2026, 651: 1068\u20131076.","journal-title":"Nature"},{"key":"1721_CR7","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCRESAHA.123.322798","volume":"134","author":"B Coste","year":"2024","unstructured":"Coste B, Delmas P. PIEZO ion channels in cardiovascular functions and diseases. Circ Res 2024, 134: 572\u2013591.","journal-title":"Circ Res"},{"key":"1721_CR8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119599119","volume":"119","author":"D Candia-Rivera","year":"2022","unstructured":"Candia-Rivera D, Catrambone V, Thayer JF, Gentili C, Valenza G. Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal. Proc Natl Acad Sci U S A 2022, 119: e2119599119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1721_CR9","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41569-026-01263-1","volume":"23","author":"K Huynh","year":"2026","unstructured":"Huynh K. Vagal mechanoreceptors in the heart sense changes in blood volume. Nat Rev Cardiol 2026, 23: 216.","journal-title":"Nat Rev Cardiol"},{"key":"1721_CR10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s12264-024-01317-9","volume":"41","author":"X Wang","year":"2025","unstructured":"Wang X, Yue Z, Shi L, He W, Shao L, Liu Y, et al. Activation of centromedial amygdala GABAergic neurons produces hypotension in mice. Neurosci Bull 2025, 41: 759\u2013774.","journal-title":"Neurosci Bull"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-026-01721-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12264-026-01721-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-026-01721-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:10:13Z","timestamp":1789204213000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12264-026-01721-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":10,"alternative-id":["1721"],"URL":"https:\/\/doi.org\/10.1007\/s12264-026-01721-3","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"23 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}}]}}