{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:10:19Z","timestamp":1791141019370,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,9,11]],"date-time":"2010-09-11T00:00:00Z","timestamp":1284163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s12265-010-9222-6","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T15:32:27Z","timestamp":1284132747000},"page":"618-624","source":"Crossref","is-referenced-by-count":93,"title":["Hematologic Effects of Continuous Flow Left Ventricular Assist Devices"],"prefix":"10.1007","volume":"3","author":[{"given":"Mark S.","family":"Slaughter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,11]]},"reference":[{"issue":"5","key":"9222_CR1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/MOT.0b013e3283303750","volume":"14","author":"JR Lahpor","year":"2009","unstructured":"Lahpor, J. R. (2009). State of the art: implantable ventricular assist devices. Current Opinion in Organ Transplantation, 14(5), 554\u2013559.","journal-title":"Current Opinion in Organ Transplantation"},{"issue":"3","key":"9222_CR2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/j.semtcvs.2008.08.002","volume":"20","author":"FD Pagani","year":"2008","unstructured":"Pagani, F. D. (2008). Continuous-flow rotary left ventricular assist devices with \u201c3rd generation\u201d design. Seminars in Thoracic and Cardiovascular Surgery, 20(3), 255\u2013263.","journal-title":"Seminars in Thoracic and Cardiovascular Surgery"},{"key":"9222_CR3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.healun.2010.01.011","volume":"29","author":"MS Slaughter","year":"2010","unstructured":"Slaughter, M. S., Pagani, F. D., Rogers, J. G., Miller, L. W., Sun, B., Russell, S. D., et al. (2010). Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. The Journal of Heart and Lung Transplantation, 29, S1\u2013S39.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"4","key":"9222_CR4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jacc.2009.03.055","volume":"54","author":"FD Pagani","year":"2009","unstructured":"Pagani, F. D., Miller, L. W., Russell, S. D., Aaronson, K. D., John, R., Boyle, A. J., et al. (2009). Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. Journal of the American College of Cardiology, 54(4), 312\u2013321.","journal-title":"Journal of the American College of Cardiology"},{"issue":"Suppl 1","key":"9222_CR5","first-page":"II272","volume":"108","author":"DJ Goldstein","year":"2003","unstructured":"Goldstein, D. J. (2003). Worldwide experience with the MicroMed DeBakey Ventricular Assist Device as a bridge to transplantation. Circulation, 108(Suppl 1), II272\u2013II277.","journal-title":"Circulation"},{"issue":"9","key":"9222_CR6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMoa067758","volume":"357","author":"LW Miller","year":"2007","unstructured":"Miller, L. W., Pagani, F. D., Russell, S. D., John, R., Boyle, A. J., Aaronson, K. D., et al. (2007). Use of a continuous-flow device in patients awaiting heart transplantation. The New England Journal of Medicine, 357(9), 885\u2013896.","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"9222_CR7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejcts.2007.12.047","volume":"33","author":"U Geisen","year":"2008","unstructured":"Geisen, U., Heilmann, C., Beyersdorf, F., Benk, C., Berchtold-Herz, M., Schlensak, C., et al. (2008). Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. European Journal of Cardiothoracic Surgery, 33(4), 679\u2013684.","journal-title":"European Journal of Cardiothoracic Surgery"},{"issue":"1","key":"9222_CR8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.healun.2003.10.018","volume":"24","author":"GV Letsou","year":"2005","unstructured":"Letsou, G. V., Shah, N., Gregoric, I. D., Myers, T. J., Delgado, R., & Frazier, O. H. (2005). Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-flow left ventricular assist device. The Journal of Heart and Lung Transplantation, 24(1), 105\u2013109.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"2","key":"9222_CR9","first-page":"116","volume":"8","author":"DG Pennington","year":"1989","unstructured":"Pennington, D. G., McBride, L. R., Kanter, K. R., Miller, L. W., Ruzevich, S. A., Naunheim, K., et al. (1989). Bridging to heart transplantation with circulatory support devices. The Journal of Heart Transplantation, 8(2), 116\u2013123.","journal-title":"The Journal of Heart Transplantation"},{"issue":"6","key":"9222_CR10","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/0003-4975(92)90393-I","volume":"53","author":"OH Frazier","year":"1992","unstructured":"Frazier, O. H., Rose, E. A., Macmanus, Q., Burton, N. A., Lefrak, E. A., Poirier, V. L., et al. (1992). Multicenter clinical evaluation of the HeartMate 1000 IP left ventricular assist device. The Annals of Thoracic Surgery, 53(6), 1080\u20131090.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"2","key":"9222_CR11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-4975(93)91174-L","volume":"56","author":"RA Guyton","year":"1993","unstructured":"Guyton, R. A., Schonberger, J. P., Everts, P. A., Jett, G. K., Gray, L. A., Jr., Gielchinsky, I., et al. (1993). Postcardiotomy shock: clinical evaluation of the BVS 5000 Biventricular Support System. The Annals of Thoracic Surgery, 56(2), 346\u2013356.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"23","key":"9222_CR12","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","volume":"361","author":"MS Slaughter","year":"2009","unstructured":"Slaughter, M. S., Rogers, J. G., Milano, C. A., Russell, S. D., Conte, J. V., Feldman, D., et al. (2009). Advanced heart failure treated with continuous-flow left ventricular assist device. The New England Journal of Medicine, 361(23), 2241\u20132251.","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"9222_CR13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAT.0b013e318161a987","volume":"54","author":"MS Slaughter","year":"2008","unstructured":"Slaughter, M. S., Sobieski, M. A., Gallagher, C., Graham, J., Brandise, J., & Stein, R. (2008). Fibrinolytic activation during long-term support with the HeartMate II left ventricular assist device. ASAIO Journal, 54(1), 115\u2013119.","journal-title":"ASAIO Journal"},{"key":"9222_CR14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.athoracsur.2009.06.095","volume":"88","author":"R John","year":"2009","unstructured":"John, R., Panch, S., Hrabe, J., Wei, P., Solovey, A., Joyce, L., et al. (2009). Activation of endothelial and coagulation systems in left ventricular assist device recipients. The Annals of Thoracic Surgery, 88, 1171\u20131179.","journal-title":"The Annals of Thoracic Surgery"},{"key":"9222_CR15","first-page":"II227","volume":"94","author":"ER Livingston","year":"1996","unstructured":"Livingston, E. R., Fisher, C. A., Bibidakis, E. J., Pathak, A. S., Todd, B. A., Furukawa, S., et al. (1996). Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. Circulation, 94, II227\u2013II234.","journal-title":"Circulation"},{"key":"9222_CR16","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0022-5223(96)70111-3","volume":"112","author":"T Spanier","year":"1996","unstructured":"Spanier, T., Oz, M., Levin, H., Weinberg, A., Stamatis, K., Stern, D., et al. (1996). Activation of coagulation and fibrinolytic pathways in patients with left ventricular assist devices. The Journal of Thoracic and Cardiovascular Surgery, 112, 1090\u20131097.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"4","key":"9222_CR17","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jtcvs.2005.02.068","volume":"130","author":"NH Thoennissen","year":"2005","unstructured":"Thoennissen, N. H., Schneider, M., Allroggen, A., Ritter, M., Dittrich, R., Schmid, C., et al. (2005). High level of cerebral microembolization in patients supported with the DeBakey left ventricular assist device. The Journal of Thoracic and Cardiovascular Surgery, 130(4), 1159\u20131166.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"9233","key":"9222_CR18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0140-6736(00)02680-5","volume":"356","author":"S Westaby","year":"2000","unstructured":"Westaby, S., Banning, A. P., Jarvik, R., Frazier, O. H., Pigott, D. W., Jin, X. Y., et al. (2000). First permanent implant of the Jarvik 2000 Heart. Lancet, 356(9233), 900\u2013903.","journal-title":"Lancet"},{"issue":"3","key":"9222_CR19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.hlc.2007.04.012","volume":"17","author":"H Hayes","year":"2008","unstructured":"Hayes, H., Dembo, L., Larbalestier, R., & O\u2019Driscoll, G. (2008). Successful treatment of ventricular assist device associated ventricular thrombus with systemic tenecteplase. Heart, Lung & Circulation, 17(3), 253\u2013255.","journal-title":"Heart, Lung & Circulation"},{"issue":"2","key":"9222_CR20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.healun.2003.10.023","volume":"24","author":"R Delgado 3rd","year":"2005","unstructured":"Delgado, R., 3rd, Frazier, O. H., Myers, T. J., Gregoric, I. D., Robertson, K., & Shah, N. A. (2005). Direct thrombolytic therapy for intraventricular thrombosis in patients with the Jarvik 2000 left ventricular assist device. The Journal of Heart and Lung Transplantation, 24(2), 231\u2013233.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"22","key":"9222_CR21","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1161\/01.CIR.0000018165.24503.5B","volume":"105","author":"S Westaby","year":"2002","unstructured":"Westaby, S., Banning, A. P., Saito, S., Pigott, D. W., Jin, X. Y., Catarino, P. A., et al. (2002). Circulatory support for long-term treatment of heart failure: experience with an intraventricular continuous flow pump. Circulation, 105(22), 2588\u20132591.","journal-title":"Circulation"},{"issue":"1","key":"9222_CR22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jtcvs.2008.07.032","volume":"137","author":"S Crow","year":"2009","unstructured":"Crow, S., John, R., Boyle, A., Shumway, S., Liao, K., Colvin-Adams, M., et al. (2009). Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. The Journal of Thoracic and Cardiovascular Surgery, 137(1), 208\u2013215.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"2S","key":"9222_CR23","first-page":"S9","volume":"29","author":"NO Mason","year":"2010","unstructured":"Mason, N. O., Reid, B. B., Marmstan, G., Jones, J., Stoker, S., Budge, D., et al. (2010). Characterization of gastrointestinal bleeding in Heartmate II left ventricular assist device patients. The Journal of Heart and Lung Transplantation, 29(2S), S9.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"2S","key":"9222_CR24","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.healun.2009.11.012","volume":"29","author":"IW Wang","year":"2010","unstructured":"Wang, I. W., Guthrie, T., Ewald, G. A., Geltman, E. M., Joseph, S., & Moazami, N. (2010). Gastrointestinal bleeding complications in continuous flow LVAD patients\u2014is it device specific? The Journal of Heart and Lung Transplantation, 29(2S), S8.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"5","key":"9222_CR25","first-page":"A213","volume":"136","author":"MA Siddiqui","year":"2009","unstructured":"Siddiqui, M. A., Slaughter, M. S., & Silva, R. G. (2009). Gastrointestinal complications in patients supported with ventricular assist devices. Gastroenterology, 136(5), A213\u2013A214.","journal-title":"Gastroenterology"},{"issue":"9","key":"9222_CR26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2009.05.018","volume":"28","author":"AJ Boyle","year":"2009","unstructured":"Boyle, A. J., Russell, S. D., Teuteberg, J. J., Slaughter, M. S., Moazami, N., Pagani, F. D., et al. (2009). Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. The Journal of Heart and Lung Transplantation, 28(9), 881\u2013887.","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"9222_CR27","first-page":"196","volume":"259","author":"EC Heyde","year":"1958","unstructured":"Heyde, E. C. (1958). Gastrointestinal bleeding in aortic stenosis [letter]. The New England Journal of Medicine, 259, 196.","journal-title":"The New England Journal of Medicine"},{"issue":"8810","key":"9222_CR28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0140-6736(92)92434-H","volume":"340","author":"TE Warkentin","year":"1992","unstructured":"Warkentin, T. E., Moore, J. C., & Morgan, D. G. (1992). Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand\u2019s disease the link? Lancet, 340(8810), 35\u201337.","journal-title":"Lancet"},{"issue":"1","key":"9222_CR29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.7326\/0003-4819-105-1-54","volume":"105","author":"MS Cappell","year":"1986","unstructured":"Cappell, M. S., & Lebwohl, O. (1986). Cessation of recurrent bleeding from gastrointestinal angiodysplasias after aortic valve replacement. Annals of Internal Medicine, 105(1), 54\u201357.","journal-title":"Annals of Internal Medicine"},{"issue":"1","key":"9222_CR30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijcard.2006.01.014","volume":"115","author":"C Sucker","year":"2007","unstructured":"Sucker, C. (2007). The Heyde syndrome: proposal for a unifying concept explaining the association of aortic valve stenosis, gastrointestinal angiodysplasia and bleeding. International Journal of Cardiology, 115(1), 77\u201378.","journal-title":"International Journal of Cardiology"},{"issue":"18","key":"9222_CR31","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200310303491817","volume":"349","author":"RC Williams Jr","year":"2003","unstructured":"Williams, R. C., Jr. (2003). Aortic stenosis, von Willebrand factor, and bleeding. The New England Journal of Medicine, 349(18), 1773\u20131774. author reply 1773\u20134.","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"9222_CR32","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.102.11.1290","volume":"102","author":"FI Pareti","year":"2000","unstructured":"Pareti, F. I., Lattuada, A., Bressi, C., Zanobini, M., Sala, A., Steffan, A., et al. (2000). Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis. Circulation, 102(11), 1290\u20131295.","journal-title":"Circulation"},{"issue":"2","key":"9222_CR33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.athoracsur.2005.07.074","volume":"81","author":"K Yoshida","year":"2006","unstructured":"Yoshida, K., Tobe, S., Kawata, M., & Yamaguchi, M. (2006). Acquired and reversible von Willebrand disease with high shear stress aortic valve stenosis. The Annals of Thoracic Surgery, 81(2), 490\u2013494.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"15","key":"9222_CR34","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/archinte.163.15.1821","volume":"163","author":"P Batur","year":"2003","unstructured":"Batur, P., Stewart, W. J., & Isaacson, J. H. (2003). Increased prevalence of aortic stenosis in patients with arteriovenous malformations of the gastrointestinal tract in Heyde syndrome. Archives of Internal Medicine, 163(15), 1821\u20131824.","journal-title":"Archives of Internal Medicine"},{"issue":"1","key":"9222_CR35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.athoracsur.2006.05.082","volume":"83","author":"A Morishima","year":"2007","unstructured":"Morishima, A., Marui, A., Shimamoto, T., Saji, Y., Tambara, K., Nishina, T., et al. (2007). Successful aortic valve replacement for Heyde syndrome with confirmed hematologic recovery. The Annals of Thoracic Surgery, 83(1), 287\u2013288.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"6","key":"9222_CR36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ejcts.2009.01.042","volume":"35","author":"D Malehsa","year":"2009","unstructured":"Malehsa, D., Meyer, A. L., Bara, C., & Struber, M. (2009). Acquired von Willebrand syndrome after exchange of the HeartMate XVE to the HeartMate II ventricular assist device. European Journal of Cardiothoracic Surgery, 35(6), 1091\u20131093.","journal-title":"European Journal of Cardiothoracic Surgery"},{"issue":"23","key":"9222_CR37","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.jacc.2009.02.048","volume":"53","author":"J Klovaite","year":"2009","unstructured":"Klovaite, J., Gustafsson, F., Mortensen, S. A., Sander, K., & Nielsen, L. B. (2009). Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II). Journal of the American College of Cardiology, 53(23), 2162\u20132167.","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"9222_CR38","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jtcvs.2007.12.077","volume":"136","author":"R John","year":"2008","unstructured":"John, R., Kamdar, F., Liao, K., Colvin-Adams, M., Miller, L., Joyce, L., et al. (2008). Low thromboembolic risk for patients with the Heartmate II left ventricular assist device. The Journal of Thoracic and Cardiovascular Surgery, 136(5), 1318\u20131323.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"2S","key":"9222_CR39","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1016\/j.healun.2008.11.879","volume":"28","author":"MS Slaughter","year":"2009","unstructured":"Slaughter, M. S., Naka, Y., John, R., Boyle, A. J., Conte, J. V., Russell, S. D., et al. (2009). Postoperative heparin is not required in transitioning patients with HeartMate II LVAD to long term warfarin therapy. The Journal of Heart and Lung Transplantation, 28(2S), S153.","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"9222_CR40","first-page":"9","volume-title":"ISHLT monograft series","author":"WL Holman","year":"2006","unstructured":"Holman, W. L., Teitel, E. R., & Itescu, S. (2006). Biologic barriers to mechanical circulatory support. In O. H. Frazier & J. K. Kirklin (Eds.), ISHLT monograft series (pp. 9\u201332). New York: Elsevier."},{"issue":"5","key":"9222_CR41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/01.MAT.0000136515.97686.A2","volume":"50","author":"N Bonaros","year":"2004","unstructured":"Bonaros, N., Mueller, M. R., Salat, A., Schima, H., Roethy, W., Kocher, A. A., et al. (2004). Extensive coagulation monitoring in patients after implantation of the MicroMed Debakey continuous flow axial pump. ASAIO Journal, 50(5), 424\u2013431.","journal-title":"ASAIO Journal"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-010-9222-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-010-9222-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-010-9222-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T06:56:16Z","timestamp":1559458576000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-010-9222-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["9222"],"URL":"https:\/\/doi.org\/10.1007\/s12265-010-9222-6","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,11]]}}}