{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:08Z","timestamp":1792788608299,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12265-011-9312-0","type":"journal-article","created":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T18:54:03Z","timestamp":1311620043000},"page":"710-719","source":"Crossref","is-referenced-by-count":71,"title":["Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium"],"prefix":"10.1007","volume":"4","author":[{"given":"Joyce","family":"Bischoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,26]]},"reference":[{"key":"9312_CR1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/dvdy.20051","volume":"230","author":"J Lincoln","year":"2004","unstructured":"Lincoln, J., Alfieri, C. M., & Yutzey, K. E. (2004). Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Developmental Dynamics, 230, 239\u2013250.","journal-title":"Developmental Dynamics"},{"key":"9312_CR2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.RES.0000141429.13560.cb","volume":"95","author":"FJ Lange de","year":"2004","unstructured":"de Lange, F. J., Moorman, A. F., Anderson, R. H., Manner, J., Soufan, A. T., de Gier-de Vries, C., et al. (2004). Lineage and morphogenetic analysis of the cardiac valves. Circulation Research, 95, 645\u2013654.","journal-title":"Circulation Research"},{"key":"9312_CR3","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2353\/ajpath.2007.070251","volume":"171","author":"AC Liu","year":"2007","unstructured":"Liu, A. C., Joag, V. R., & Gotlieb, A. I. (2007). The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. American Journal of Pathology, 171, 1407\u20131418.","journal-title":"American Journal of Pathology"},{"key":"9312_CR4","first-page":"331","volume":"74","author":"BJ Maron","year":"1974","unstructured":"Maron, B. J., & Hutchins, G. M. (1974). The development of the semilunar valves in the human heart. American Journal of Pathology, 74, 331\u2013344.","journal-title":"American Journal of Pathology"},{"key":"9312_CR5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00315641","volume":"157","author":"JM Hurle","year":"1979","unstructured":"Hurle, J. M. (1979). Scanning and light microscope studies of the development of the chick embryo semilunar heart valves. Anatomy and Embryology, 157, 69\u201380.","journal-title":"Anatomy and Embryology"},{"key":"9312_CR6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00315651","volume":"160","author":"JM Hurle","year":"1980","unstructured":"Hurle, J. M., Colvee, E., & Blanco, A. M. (1980). Development of mouse semilunar valves. Anatomy and Embryology, 160, 83\u201391.","journal-title":"Anatomy and Embryology"},{"key":"9312_CR7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00304601","volume":"167","author":"JM Hurle","year":"1983","unstructured":"Hurle, J. M., & Colvee, E. (1983). Changes in the endothelial morphology of the developing semilunar heart valves. A tem and sem study in the chick. Anatomy and Embryology, 167, 67\u201383.","journal-title":"Anatomy and Embryology"},{"key":"9312_CR8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/cvr\/20.10.760","volume":"20","author":"JD Deck","year":"1986","unstructured":"Deck, J. D. (1986). Endothelial cell orientation on aortic valve leaflets. Cardiovascular Research, 20, 760\u2013767.","journal-title":"Cardiovascular Research"},{"key":"9312_CR9","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.ATV.0000130462.50769.5a","volume":"24","author":"JT Butcher","year":"2004","unstructured":"Butcher, J. T., Penrod, A. M., Garcia, A. J., & Nerem, R. M. (2004). Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1429\u20131434.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9312_CR10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.RES.0000161998.92009.64","volume":"96","author":"CA Simmons","year":"2005","unstructured":"Simmons, C. A., Grant, G. R., Manduchi, E., & Davies, P. F. (2005). Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation Research, 96, 792\u2013799.","journal-title":"Circulation Research"},{"key":"9312_CR11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.ATV.0000196624.70507.0d","volume":"26","author":"JT Butcher","year":"2006","unstructured":"Butcher, J. T., Tressel, S., Johnson, T., Turner, D., Sorescu, G., Jo, H., et al. (2006). Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 69\u201377.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9312_CR12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/ATVBAHA.109.198549","volume":"30","author":"MA Guerraty","year":"2010","unstructured":"Guerraty, M. A., Grant, G. R., Karanian, J. W., Chiesa, O. A., Pritchard, W. F., & Davies, P. F. (2010). Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 225\u2013231.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9312_CR13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/ATVBAHA.108.176347","volume":"29","author":"P Sucosky","year":"2009","unstructured":"Sucosky, P., Balachandran, K., Elhammali, A., Jo, H., & Yoganathan, A. P. (2009). Altered shear stress stimulates upregulation of endothelial vcam-1 and icam-1 in a bmp-4- and tgf-beta1-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 29, 254\u2013260.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9312_CR14","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/CIRCULATIONAHA.105.591768","volume":"113","author":"E Aikawa","year":"2006","unstructured":"Aikawa, E., Whittaker, P., Farber, M., Mendelson, K., Padera, R. F., Aikawa, M., et al. (2006). Human semilunar cardiac valve remodeling by activated cells from fetus to adult: Implications for postnatal adaptation, pathology, and tissue engineering. Circulation, 113, 1344\u20131352.","journal-title":"Circulation"},{"key":"9312_CR15","doi-asserted-by":"crossref","first-page":"10623","DOI":"10.1073\/pnas.1434429100","volume":"100","author":"JT Chi","year":"2003","unstructured":"Chi, J. T., Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., et al. (2003). Endothelial cell diversity revealed by global expression profiling. Proceedings of the National Academy of Sciences of the United States of America, 100, 10623\u201310628.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9312_CR16","first-page":"589","volume":"49","author":"CM Johnson","year":"1983","unstructured":"Johnson, C. M., & Fass, D. N. (1983). Porcine cardiac valvular endothelial cells in culture. A relative deficiency of fibronectin synthesis in vitro. Laboratory Investigation, 49, 589\u2013598.","journal-title":"Laboratory Investigation"},{"key":"9312_CR17","first-page":"1401","volume":"142","author":"CM Johnson","year":"1993","unstructured":"Johnson, C. M., & Helgeson, S. C. (1993). Fibronectin biosynthesis and cell-surface expression by cardiac and non-cardiac endothelial cells. American Journal of Pathology, 142, 1401\u20131408.","journal-title":"American Journal of Pathology"},{"key":"9312_CR18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1540-8191.1993.tb00426.x","volume":"8","author":"A Simon","year":"1993","unstructured":"Simon, A., Zavazava, N., Sievers, H. H., & Muller-Ruchholtz, W. (1993). In vitro cultivation and immunogenicity of human cardiac valve endothelium. Journal of Cardiac Surgery, 8, 656\u2013665.","journal-title":"Journal of Cardiac Surgery"},{"key":"9312_CR19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/aja.1001480108","volume":"148","author":"RR Markwald","year":"1977","unstructured":"Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977). Structural development of endocardial cushions. The American Journal of Anatomy, 148, 85\u2013119.","journal-title":"The American Journal of Anatomy"},{"key":"9312_CR20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0012-1606(75)90321-8","volume":"42","author":"RR Markwald","year":"1975","unstructured":"Markwald, R. R., Fitzharris, T. P., & Smith, W. N. (1975). Structural analysis of endocardial cytodifferentiation. Developmental Biology, 42, 160\u2013180.","journal-title":"Developmental Biology"},{"key":"9312_CR21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0012-1606(85)90414-2","volume":"112","author":"EL Krug","year":"1985","unstructured":"Krug, E. L., Runyan, R. B., & Markwald, R. R. (1985). Protein extracts from early embryonic hearts initiate cardiac endothelial cytodifferentiation. Developmental Biology, 112, 414\u2013426.","journal-title":"Developmental Biology"},{"key":"9312_CR22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000147845","volume":"156","author":"R Markwald","year":"1996","unstructured":"Markwald, R., Eisenberg, C., Eisenberg, L., Trusk, T., & Sugi, Y. (1996). Epithelial-mesenchymal transformations in early avian heart development. Acta Anatomica, 156, 173\u2013186.","journal-title":"Acta Anatomica"},{"key":"9312_CR23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ydbio.2004.01.045","volume":"269","author":"Y Sugi","year":"2004","unstructured":"Sugi, Y., Yamamura, H., Okagawa, H., & Markwald, R. R. (2004). Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice. Developmental Biology, 269, 505\u2013518.","journal-title":"Developmental Biology"},{"key":"9312_CR24","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1242\/dev.02156","volume":"132","author":"L Ma","year":"2005","unstructured":"Ma, L., Lu, M. F., Schwartz, R. J., & Martin, J. F. (2005). Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development, 132, 5601\u20135611.","journal-title":"Development"},{"key":"9312_CR25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ydbio.2006.03.043","volume":"295","author":"J Rivera-Feliciano","year":"2006","unstructured":"Rivera-Feliciano, J., & Tabin, C. J. (2006). Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field. Developmental Biology, 295, 580\u2013588.","journal-title":"Developmental Biology"},{"key":"9312_CR26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/dbio.1996.0070","volume":"174","author":"CB Brown","year":"1996","unstructured":"Brown, C. B., Boyer, A. S., Runyan, R. B., & Barnett, J. V. (1996). Antibodies to the type ii tgfbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart. Developmental Biology, 174, 248\u2013257.","journal-title":"Developmental Biology"},{"key":"9312_CR27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0074-7696(05)43005-3","volume":"243","author":"AD Person","year":"2005","unstructured":"Person, A. D., Klewer, S. E., & Runyan, R. B. (2005). Cell biology of cardiac cushion development. International Review of Cytology, 243, 287\u2013335.","journal-title":"International Review of Cytology"},{"key":"9312_CR28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.200403050","volume":"166","author":"S Liebner","year":"2004","unstructured":"Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., Piccolo, S., et al. (2004). Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. The Journal of Cell Biology, 166, 359\u2013367.","journal-title":"The Journal of Cell Biology"},{"key":"9312_CR29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.276304","volume":"18","author":"LA Timmerman","year":"2004","unstructured":"Timmerman, L. A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J. M., Diez, J., et al. (2004). Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development, 18, 99\u2013115.","journal-title":"Genes & Development"},{"key":"9312_CR30","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCRESAHA.109.201566","volume":"105","author":"MD Combs","year":"2009","unstructured":"Combs, M. D., & Yutzey, K. E. (2009). Heart valve development: regulatory networks in development and disease. Circulation Research, 105, 408\u2013421.","journal-title":"Circulation Research"},{"key":"9312_CR31","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/bdra.20799","volume":"91","author":"J Lincoln","year":"2011","unstructured":"Lincoln, J., & Yutzey, K. E. (2011). Molecular and developmental mechanisms of congenital heart valve disease. Birth Defects Research. Part A, Clinical and Molecular Teratology, 91, 526\u2013534.","journal-title":"Birth Defects Research. Part A, Clinical and Molecular Teratology"},{"key":"9312_CR32","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0002-9440(10)62520-5","volume":"159","author":"G Paranya","year":"2001","unstructured":"Paranya, G., Vineberg, S., Dvorin, E., Kaushal, S., Roth, S. J., Rabkin, E., et al. (2001). Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro. American Journal of Pathology, 159, 1335\u20131343.","journal-title":"American Journal of Pathology"},{"key":"9312_CR33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/01.RES.0000245188.41002.2c","volume":"99","author":"S Paruchuri","year":"2006","unstructured":"Paruchuri, S., Yang, J. H., Aikawa, E., Melero-Martin, J. M., Khan, Z. A., Loukogeorgakis, S., et al. (2006). Human pulmonary valve progenitor cells exhibit endothelial\/mesenchymal plasticity in response to vascular endothelial growth factor-a and transforming growth factor-beta2. Circulation Research, 99, 861\u2013869.","journal-title":"Circulation Research"},{"key":"9312_CR34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbrc.2008.07.057","volume":"374","author":"JH Yang","year":"2008","unstructured":"Yang, J. H., Wylie-Sears, J., & Bischoff, J. (2008). Opposing actions of notch1 and vegf in post-natal cardiac valve endothelial cells. Biochemical and Biophysical Research Communications, 374, 512\u2013516.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9312_CR35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.107.749440","volume":"118","author":"M Chaput","year":"2008","unstructured":"Chaput, M., Handschumacher, M. D., Tournoux, F., Hua, L., Guerrero, J. L., Vlahakes, G. J., et al. (2008). Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation. Circulation, 118, 845\u2013852.","journal-title":"Circulation"},{"key":"9312_CR36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.108.846782","volume":"120","author":"JP Dal-Bianco","year":"2009","unstructured":"Dal-Bianco, J. P., Aikawa, E., Bischoff, J., Guerrero, J. L., Handschumacher, M. D., Sullivan, S., et al. (2009). Active adaptation of the tethered mitral valve: Insights into a compensatory mechanism for functional mitral regurgitation. Circulation, 120, 334\u2013342.","journal-title":"Circulation"},{"key":"9312_CR37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ydbio.2006.03.027","volume":"294","author":"J Lincoln","year":"2006","unstructured":"Lincoln, J., Lange, A. W., & Yutzey, K. E. (2006). Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Developmental Biology, 294, 292\u2013302.","journal-title":"Developmental Biology"},{"key":"9312_CR38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science, 284, 143\u2013147.","journal-title":"Science"},{"key":"9312_CR39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/ATVBAHA.110.216184","volume":"31","author":"J Wylie-Sears","year":"2011","unstructured":"Wylie-Sears, J., Aikawa, E., Levine, R. A., Yang, J. H., & Bischoff, J. (2011). Mitral valve endothelial cells with osteogenic differentiation potential. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 598\u2013607.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9312_CR40","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1182\/blood-2006-12-062471","volume":"109","author":"JM Melero-Martin","year":"2007","unstructured":"Melero-Martin, J. M., Khan, Z. A., Picard, A., Wu, X., Paruchuri, S., & Bischoff, J. (2007). In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood, 109, 4761\u20134768.","journal-title":"Blood"},{"key":"9312_CR41","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1182\/blood-2004-04-1396","volume":"104","author":"DA Ingram","year":"2004","unstructured":"Ingram, D. A., Mead, L. E., Tanaka, H., Meade, V., Fenoglio, A., Mortell, K., et al. (2004). Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood, 104, 2752\u20132760.","journal-title":"Blood"},{"key":"9312_CR42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s11626-998-0007-z","volume":"34","author":"BM Kraling","year":"1998","unstructured":"Kraling, B. M., & Bischoff, J. (1998). A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors. In Vitro Cellular & Developmental Biology\u2013Animal, 34, 308\u2013315.","journal-title":"In Vitro Cellular & Developmental Biology\u2013Animal"},{"key":"9312_CR43","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","volume":"107","author":"NM Rajamannan","year":"2003","unstructured":"Rajamannan, N. M., Subramaniam, M., Rickard, D., Stock, S. R., Donovan, J., Springett, M., et al. (2003). Human aortic valve calcification is associated with an osteoblast phenotype. Circulation, 107, 2181\u20132184.","journal-title":"Circulation"},{"key":"9312_CR44","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2353\/ajpath.2009.080750","volume":"174","author":"JH Chen","year":"2009","unstructured":"Chen, J. H., Yip, C. Y., Sone, E. D., & Simmons, C. A. (2009). Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. American Journal of Pathology, 174, 1109\u20131119.","journal-title":"American Journal of Pathology"},{"key":"9312_CR45","doi-asserted-by":"crossref","first-page":"I547","DOI":"10.1161\/CIRCULATIONAHA.106.634691","volume":"114","author":"L Osman","year":"2006","unstructured":"Osman, L., Yacoub, M. H., Latif, N., Amrani, M., & Chester, A. H. (2006). Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation, 114, I547\u2013552.","journal-title":"Circulation"},{"key":"9312_CR46","first-page":"421","volume":"18","author":"J Bouchard-Martel","year":"2009","unstructured":"Bouchard-Martel, J., Roussel, E., Drolet, M. C., Arsenault, M., & Couet, J. (2009). Interstitial cells from left-sided heart valves display more calcification potential than from right-sided valves: an in-vitro study of porcine valves. The Journal of Heart Valve Disease, 18, 421\u2013428.","journal-title":"The Journal of Heart Valve Disease"},{"key":"9312_CR47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.106.654913","volume":"115","author":"E Aikawa","year":"2007","unstructured":"Aikawa, E., Nahrendorf, M., Sosnovik, D., Lok, V. M., Jaffer, F. A., Aikawa, M., et al. (2007). Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation, 115, 377\u2013386.","journal-title":"Circulation"},{"issue":"Pt 2","key":"9312_CR48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1242\/jcs.103.2.521","volume":"103","author":"E Arciniegas","year":"1992","unstructured":"Arciniegas, E., Sutton, A. B., Allen, T. D., & Schor, A. M. (1992). Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. Journal of Cell Science, 103(Pt 2), 521\u2013529.","journal-title":"Journal of Cell Science"},{"key":"9312_CR49","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/01.RES.0000021432.70309.28","volume":"90","author":"MG Frid","year":"2002","unstructured":"Frid, M. G., Kale, V. A., & Stenmark, K. R. (2002). Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circulation Research, 90, 1189\u20131196.","journal-title":"Circulation Research"},{"key":"9312_CR50","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1074\/jbc.M207329200","volume":"278","author":"A Ishisaki","year":"2003","unstructured":"Ishisaki, A., Hayashi, H., Li, A. J., & Imamura, T. (2003). Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells. Journal of Biological Chemistry, 278, 1303\u20131309.","journal-title":"Journal of Biological Chemistry"},{"key":"9312_CR51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ccr.2008.06.017","volume":"14","author":"AC Dudley","year":"2008","unstructured":"Dudley, A. C., Khan, Z. A., Shih, S. C., Kang, S. Y., Zwaans, B. M., Bischoff, J., et al. (2008). Calcification of multipotent prostate tumor endothelium. Cancer Cell, 14, 201\u2013211.","journal-title":"Cancer Cell"},{"key":"9312_CR52","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","volume":"13","author":"EM Zeisberg","year":"2007","unstructured":"Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., et al. (2007). Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature Medicine, 13, 952\u2013961.","journal-title":"Nature Medicine"},{"key":"9312_CR53","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/CIRCRESAHA.110.231910","volume":"107","author":"EM Zeisberg","year":"2010","unstructured":"Zeisberg, E. M., & Kalluri, R. (2010). Origins of cardiac fibroblasts. Circulation Research, 107, 1304\u20131312.","journal-title":"Circulation Research"},{"key":"9312_CR54","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/nm.2252","volume":"16","author":"D Medici","year":"2010","unstructured":"Medici, D., Shore, E. M., Lounev, V. Y., Kaplan, F. S., Kalluri, R., & Olsen, B. R. (2010). Conversion of vascular endothelial cells into multipotent stem-like cells. Nature Medicine, 16, 1400\u20131406.","journal-title":"Nature Medicine"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-011-9312-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-011-9312-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-011-9312-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T18:42:44Z","timestamp":1638124964000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-011-9312-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,26]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9312"],"URL":"https:\/\/doi.org\/10.1007\/s12265-011-9312-0","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,26]]}}}