{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:34:59Z","timestamp":1761597299041},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12265-011-9317-8","type":"journal-article","created":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T18:23:20Z","timestamp":1314210200000},"page":"727-740","source":"Crossref","is-referenced-by-count":12,"title":["Role of Angiogenetic Factors in Cardiac Valve Homeostasis and Disease"],"prefix":"10.1007","volume":"4","author":[{"given":"Daihiko","family":"Hakuno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naritaka","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoyo","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,25]]},"reference":[{"key":"9317_CR1","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","volume":"111","author":"RV Freeman","year":"2005","unstructured":"Freeman, R. V., & Otto, C. M. (2005). Spectrum of calcific aortic valve disease: Pathogenesis, disease progression, and treatment strategies. Circulation, 111, 3316\u20133326.","journal-title":"Circulation"},{"key":"9317_CR2","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","volume":"103","author":"ER Mohler 3rd","year":"2001","unstructured":"Mohler, E. R., 3rd, Gannon, F., Reynolds, C., Zimmerman, R., Keane, M. G., & Kaplan, F. S. (2001). Bone formation and inflammation in cardiac valves. Circulation, 103, 1522\u20131528.","journal-title":"Circulation"},{"key":"9317_CR3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/heart.89.7.801","volume":"89","author":"NM Rajamannan","year":"2003","unstructured":"Rajamannan, N. M., Gersh, B., & Bonow, R. O. (2003). Calcific aortic stenosis: From bench to the bedside\u2014Emerging clinical and cellular concepts. Heart, 89, 801\u2013805.","journal-title":"Heart"},{"key":"9317_CR4","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/01.CIR.0000140722.85490.EA","volume":"110","author":"NM Rajamannan","year":"2004","unstructured":"Rajamannan, N. M., & Otto, C. M. (2004). Targeted therapy to prevent progression of calcific aortic stenosis. Circulation, 110, 1180\u20131182.","journal-title":"Circulation"},{"key":"9317_CR5","doi-asserted-by":"crossref","first-page":"I547","DOI":"10.1161\/CIRCULATIONAHA.106.634691","volume":"114","author":"L Osman","year":"2006","unstructured":"Osman, L., Yacoub, M. H., Latif, N., Amrani, M., & Chester, A. H. (2006). Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation, 114, I547\u2013I552.","journal-title":"Circulation"},{"key":"9317_CR6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ncpcardio0827","volume":"4","author":"NM Rajamannan","year":"2007","unstructured":"Rajamannan, N. M., Bonow, R. O., & Rahimtoola, S. H. (2007). Calcific aortic stenosis: An update. Nature Clinical Practice. Cardiovascular Medicine, 4, 254\u2013262.","journal-title":"Nature Clinical Practice. Cardiovascular Medicine"},{"key":"9317_CR7","first-page":"261","volume":"22","author":"F Ortolani","year":"2007","unstructured":"Ortolani, F., Bonetti, A., Tubaro, F., et al. (2007). Ultrastructural characterization of calcification onset and progression in subdermally implanted aortic valves. Histochemical and spectrometric data. Histology and Histopathology, 22, 261\u2013272.","journal-title":"Histology and Histopathology"},{"key":"9317_CR8","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","volume":"107","author":"NM Rajamannan","year":"2003","unstructured":"Rajamannan, N. M., Subramaniam, M., Rickard, D., et al. (2003). Human aortic valve calcification is associated with an osteoblast phenotype. Circulation, 107, 2181\u20132184.","journal-title":"Circulation"},{"key":"9317_CR9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/MOL.0b013e3282a66099","volume":"18","author":"S Helske","year":"2007","unstructured":"Helske, S., Kupari, M., Lindstedt, K. A., & Kovanen, P. T. (2007). Aortic valve stenosis: An active atheroinflammatory process. Current Opinion in Lipidology, 18, 483\u2013491.","journal-title":"Current Opinion in Lipidology"},{"key":"9317_CR10","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1161\/CIRCULATIONAHA.108.827972","volume":"119","author":"E Aikawa","year":"2009","unstructured":"Aikawa, E., Aikawa, M., Libby, P., et al. (2009). Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation, 119, 1785\u20131794.","journal-title":"Circulation"},{"key":"9317_CR11","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1161\/01.ATV.0000227513.13697.ac","volume":"26","author":"KD O\u2019Brien","year":"2006","unstructured":"O\u2019Brien, K. D. (2006). Pathogenesis of calcific aortic valve disease: A disease process comes of age (and a good deal more). Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 1721\u20131728.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9317_CR12","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.RES.0000224114.65109.4e","volume":"98","author":"RB Hinton Jr","year":"2006","unstructured":"Hinton, R. B., Jr., Lincoln, J., Deutsch, G. H., et al. (2006). Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circulation Research, 98, 1431\u20131438.","journal-title":"Circulation Research"},{"key":"9317_CR13","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMoa043876","volume":"352","author":"SJ Cowell","year":"2005","unstructured":"Cowell, S. J., Newby, D. E., Prescott, R. J., et al. (2005). A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. The New England Journal of Medicine, 352, 2389\u20132397.","journal-title":"The New England Journal of Medicine"},{"key":"9317_CR14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJMoa0804602","volume":"359","author":"AB Rosseb\u00f8","year":"2008","unstructured":"Rosseb\u00f8, A. B., Pedersen, T. R., Boman, K., et al. (2008). Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. The New England Journal of Medicine, 359, 1343\u20131356.","journal-title":"The New England Journal of Medicine"},{"key":"9317_CR15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbrc.2005.05.133","volume":"333","author":"C Shukunami","year":"2005","unstructured":"Shukunami, C., Oshima, Y., & Hiraki, Y. (2005). Chondromodulin-I and tenomodulin: A new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues. Biochemical and Biophysical Research Communications, 333, 299\u2013307.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9317_CR16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/BOR.0b013e3283103d12","volume":"20","author":"S Ashraf","year":"2008","unstructured":"Ashraf, S., & Walsh, D. A. (2008). Angiogenesis in osteoarthritis. Current Opinion in Rheumatology, 20, 573\u2013580.","journal-title":"Current Opinion in Rheumatology"},{"key":"9317_CR17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-5223(19)39728-4","volume":"68","author":"JW Hammon Jr","year":"1974","unstructured":"Hammon, J. W., Jr., O\u2019Sullivan, M. J., Oury, J., & Fosburg, R. G. (1974). Allograft cardiac valves. A view through the scanning electron microscope. The Journal of Thoracic and Cardiovascular Surgery, 68, 352\u2013360.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"9317_CR18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1469-7580.1998.19240573.x","volume":"192","author":"C Millington-Sanders","year":"1998","unstructured":"Millington-Sanders, C., Meir, A., Lawrence, L., & Stolinski, C. (1998). Structure of chordae tendineae in the left ventricle of the human heart. Journal of Anatomy, 192, 573\u2013581.","journal-title":"Journal of Anatomy"},{"key":"9317_CR19","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/eurheartj\/ehi248","volume":"26","author":"O Fondard","year":"2005","unstructured":"Fondard, O., Detaint, D., Iung, B., et al. (2005). Extracellular matrix remodelling in human aortic valve disease: The role of matrix metalloproteinases and their tissue inhibitors. European Heart Journal, 26, 1333\u20131341.","journal-title":"European Heart Journal"},{"key":"9317_CR20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.carpath.2005.01.002","volume":"14","author":"JJ Kaden","year":"2005","unstructured":"Kaden, J. J., Dempfle, C. E., Grobholz, R., et al. (2005). Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovascular Pathology, 14, 80\u201387.","journal-title":"Cardiovascular Pathology"},{"key":"9317_CR21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nm1476","volume":"12","author":"M Yoshioka","year":"2006","unstructured":"Yoshioka, M., Yuasa, S., Matsumura, K., et al. (2006). Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nature Medicine, 12, 1151\u20131159.","journal-title":"Nature Medicine"},{"key":"9317_CR22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.106.654913","volume":"115","author":"E Aikawa","year":"2007","unstructured":"Aikawa, E., Nahrendorf, M., Sosnovik, D., et al. (2007). Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation, 115, 377\u2013386.","journal-title":"Circulation"},{"key":"9317_CR23","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","volume":"104","author":"E Rabkin","year":"2001","unstructured":"Rabkin, E., Aikawa, M., Stone, J. R., Fukumoto, Y., Libby, P., & Schoen, F. J. (2001). Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation, 104, 2525\u20132532.","journal-title":"Circulation"},{"key":"9317_CR24","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.yexcr.2007.02.033","volume":"313","author":"F Chalajour","year":"2007","unstructured":"Chalajour, F., Treede, H., Gehling, U. M., et al. (2007). Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve. Experimental Cell Research, 313, 2326\u20132335.","journal-title":"Experimental Cell Research"},{"key":"9317_CR25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.yexcr.2004.04.034","volume":"298","author":"F Chalajour","year":"2004","unstructured":"Chalajour, F., Treede, H., Ebrahimnejad, A., Lauke, H., Reichenspurner, H., & Ergun, S. (2004). Angiogenic activation of valvular endothelial cells in aortic valve stenosis. Experimental Cell Research, 298, 455\u2013464.","journal-title":"Experimental Cell Research"},{"key":"9317_CR26","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/eurheartj\/ehi458","volume":"26","author":"D Skowasch","year":"2005","unstructured":"Skowasch, D., Schrempf, S., Wernert, N., et al. (2005). Cells of primarily extra-valvular origin in degenerative aortic valves and bioprostheses. European Heart Journal, 26, 2576\u20132580.","journal-title":"European Heart Journal"},{"key":"9317_CR27","first-page":"1449","volume":"63","author":"Y Hiraki","year":"1991","unstructured":"Hiraki, Y. (1991). Molecular cloning of a novel cartilage-specific functional matrix, chondromodulin-I, and its role in endochondral bone formation. Seikagaku, 63, 1449\u20131454.","journal-title":"Seikagaku"},{"key":"9317_CR28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/03008200590935547","volume":"46","author":"Y Hiraki","year":"2005","unstructured":"Hiraki, Y., & Shukunami, C. (2005). Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: Chondromodulin-I and tenomodulin. Connective Tissue Research, 46, 3\u201311.","journal-title":"Connective Tissue Research"},{"key":"9317_CR29","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/01.RES.0000191547.64391.e3","volume":"97","author":"GE Davis","year":"2005","unstructured":"Davis, G. E., & Senger, D. R. (2005). Endothelial extracellular matrix: Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circulation Research, 97, 1093\u20131107.","journal-title":"Circulation Research"},{"key":"9317_CR30","doi-asserted-by":"crossref","first-page":"27633","DOI":"10.1074\/jbc.M313617200","volume":"279","author":"A Zijlstra","year":"2004","unstructured":"Zijlstra, A., Aimes, R. T., Zhu, D., et al. (2004). Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). Journal of Biological Chemistry, 279, 27633\u201327645.","journal-title":"Journal of Biological Chemistry"},{"key":"9317_CR31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj2940271","volume":"294","author":"S Takeshita","year":"1993","unstructured":"Takeshita, S., Kikuno, R., Tezuka, K., & Amann, E. (1993). Osteoblast-specific factor 2: Cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochemical Journal, 294, 271\u2013278.","journal-title":"Biochemical Journal"},{"key":"9317_CR32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12079-010-0090-2","volume":"4","author":"HM Zhou","year":"2010","unstructured":"Zhou, H. M., Wang, J., Elliott, C., Wen, W., Hamilton, D. W., & Conway, S. J. (2010). Spatiotemporal expression of periostin during skin development and incisional wound healing: Lessons for human fibrotic scar formation. J Cell Commun Signal, 4, 99\u2013107.","journal-title":"J Cell Commun Signal"},{"key":"9317_CR33","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/CIRCRESAHA.109.201400","volume":"105","author":"P Snider","year":"2009","unstructured":"Snider, P., Standley, K. N., Wang, J., Azhar, M., Doetschman, T., & Conway, S. J. (2009). Origin of cardiac fibroblasts and the role of periostin. Circulation Research, 105, 934\u2013947.","journal-title":"Circulation Research"},{"key":"9317_CR34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.diff.2009.03.005","volume":"78","author":"SJ Dangaria","year":"2009","unstructured":"Dangaria, S. J., Ito, Y., Walker, C., Druzinsky, R., Luan, X., & Diekwisch, T. G. (2009). Extracellular matrix-mediated differentiation of periodontal progenitor cells. Differentiation, 78, 79\u201390.","journal-title":"Differentiation"},{"key":"9317_CR35","doi-asserted-by":"crossref","first-page":"13294","DOI":"10.1074\/jbc.M109.088864","volume":"285","author":"T Maruhashi","year":"2010","unstructured":"Maruhashi, T., Kii, I., Saito, M., & Kudo, A. (2010). Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. Journal of Biological Chemistry, 285, 13294\u201313303.","journal-title":"Journal of Biological Chemistry"},{"key":"9317_CR36","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1074\/jbc.M109.051961","volume":"285","author":"I Kii","year":"2010","unstructured":"Kii, I., Nishiyama, T., Li, M., et al. (2010). Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. Journal of Biological Chemistry, 285, 2028\u20132039.","journal-title":"Journal of Biological Chemistry"},{"key":"9317_CR37","doi-asserted-by":"crossref","first-page":"e18410","DOI":"10.1371\/journal.pone.0018410","volume":"6","author":"T Nishiyama","year":"2011","unstructured":"Nishiyama, T., Kii, I., Kashima, T. G., et al. (2011). Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing. PloS One, 6, e18410.","journal-title":"PloS One"},{"key":"9317_CR38","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbrc.2006.02.016","volume":"342","author":"I Kii","year":"2006","unstructured":"Kii, I., Amizuka, N., Minqi, L., Kitajima, S., Saga, Y., & Kudo, A. (2006). Periostin is an extracellular matrix protein required for eruption of incisors in mice. Biochemical and Biophysical Research Communications, 342, 766\u2013772.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9317_CR39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.ATV.0000149141.81230.c6","volume":"25","author":"V Lindner","year":"2005","unstructured":"Lindner, V., Wang, Q., Conley, B. A., Friesel, R. E., & Vary, C. P. (2005). Vascular injury induces expression of periostin: Implications for vascular cell differentiation and migration. Arteriosclerosis, Thrombosis, and Vascular Biology, 25, 77\u201383.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9317_CR40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0925-4773(01)00356-2","volume":"103","author":"A Kruzynska-Frejtag","year":"2001","unstructured":"Kruzynska-Frejtag, A., Machnicki, M., Rogers, R., Markwald, R. R., & Conway, S. J. (2001). Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation. Mechanisms of Development, 103, 183\u2013188.","journal-title":"Mechanisms of Development"},{"key":"9317_CR41","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/01.CIR.0000142607.33398.54","volume":"110","author":"N Katsuragi","year":"2004","unstructured":"Katsuragi, N., Morishita, R., Nakamura, N., et al. (2004). Periostin as a novel factor responsible for ventricular dilation. Circulation, 110, 1806\u20131813.","journal-title":"Circulation"},{"key":"9317_CR42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCRESAHA.107.149047","volume":"101","author":"T Oka","year":"2007","unstructured":"Oka, T., Xu, J., Kaiser, R. A., et al. (2007). Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circulation Research, 101, 313\u2013321.","journal-title":"Circulation Research"},{"key":"9317_CR43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.20071297","volume":"205","author":"M Shimazaki","year":"2008","unstructured":"Shimazaki, M., Nakamura, K., Kii, I., et al. (2008). Periostin is essential for cardiac healing after acute myocardial infarction. The Journal of Experimental Medicine, 205, 295\u2013303.","journal-title":"The Journal of Experimental Medicine"},{"key":"9317_CR44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1196\/annals.1420.005","volume":"1123","author":"RA Norris","year":"2008","unstructured":"Norris, R. A., Borg, T. K., Butcher, J. T., Baudino, T. A., Banerjee, I., & Markwald, R. R. (2008). Neonatal and adult cardiovascular pathophysiological remodeling and repair: Developmental role of periostin. Annals of the New York Academy of Sciences, 1123, 30\u201340.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"9317_CR45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ydbio.2006.09.048","volume":"302","author":"JT Butcher","year":"2007","unstructured":"Butcher, J. T., Norris, R. A., Hoffman, S., Mjaatvedt, C. H., & Markwald, R. R. (2007). Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho\/PI 3-kinase. Developments in Biologicals, 302, 256\u2013266.","journal-title":"Developments in Biologicals"},{"key":"9317_CR46","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/CIRCRESAHA.107.159517","volume":"102","author":"P Snider","year":"2008","unstructured":"Snider, P., Hinton, R. B., Moreno-Rodriguez, R. A., et al. (2008). Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circulation Research, 102, 752\u2013760.","journal-title":"Circulation Research"},{"key":"9317_CR47","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.RES.0000207384.81818.d4","volume":"98","author":"RP Visconti","year":"2006","unstructured":"Visconti, R. P., Ebihara, Y., LaRue, A. C., et al. (2006). An in vivo analysis of hematopoietic stem cell potential: Hematopoietic origin of cardiac valve interstitial cells. Circulation Research, 98, 690\u2013696.","journal-title":"Circulation Research"},{"key":"9317_CR48","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1432-0436.2007.00262.x","volume":"76","author":"H Lie-Venema","year":"2008","unstructured":"Lie-Venema, H., Eralp, I., Markwald, R. R., et al. (2008). Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton. Differentiation, 76, 809\u2013819.","journal-title":"Differentiation"},{"key":"9317_CR49","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1128\/MCB.24.9.3992-4003.2004","volume":"24","author":"S Bao","year":"2004","unstructured":"Bao, S., Bai, X., Blanchette, C., et al. (2004). Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Molecular and Cellular Biology, 24, 3992\u20134003.","journal-title":"Molecular and Cellular Biology"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-011-9317-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-011-9317-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-011-9317-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T16:15:40Z","timestamp":1592842540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-011-9317-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,25]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9317"],"URL":"https:\/\/doi.org\/10.1007\/s12265-011-9317-8","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,25]]}}}