{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:03:07Z","timestamp":1768834987232,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12265-016-9685-1","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T10:16:30Z","timestamp":1456913790000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["QUest for the Arrhythmogenic Substrate of Atrial fibRillation in Patients Undergoing Cardiac Surgery (QUASAR Study): Rationale and Design"],"prefix":"10.1007","volume":"9","author":[{"given":"Lisette J. M. E.","family":"van der Does","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameeta","family":"Yaksh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Kik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Knops","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva A. H.","family":"Lanters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe P.","family":"Teuwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans B. S.","family":"Oei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter C.","family":"van de Woestijne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos A.","family":"Bekkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad J. J. C.","family":"Bogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurits A.","family":"Allessie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasja M. S.","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"issue":"4","key":"9685_CR1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCEP.108.774885","volume":"1","author":"F Gaita","year":"2008","unstructured":"Gaita, F., Caponi, D., Scaglione, M., et al. (2008). Long-term clinical results of 2 different ablation strategies in patients with paroxysmal and persistent atrial fibrillation. Circulation. Arrhythmia and Electrophysiology, 1(4), 269\u2013275.","journal-title":"Circulation. Arrhythmia and Electrophysiology"},{"issue":"2","key":"9685_CR2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.004549","volume":"2","author":"AN Ganesan","year":"2013","unstructured":"Ganesan, A. N., Shipp, N. J., Brooks, A. G., et al. (2013). Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis. Journal of the American Heart Association, 2(2), e004549.","journal-title":"Journal of the American Heart Association"},{"issue":"6","key":"9685_CR3","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/europace\/eus010","volume":"14","author":"AA Mulder","year":"2012","unstructured":"Mulder, A. A., Wijffels, M. C., Wever, E. F., & Boersma, L. V. (2012). Freedom from paroxysmal atrial fibrillation after successful pulmonary vein isolation with pulmonary vein ablation catheter-phased radiofrequency energy: 2-year follow-up and predictors of failure. Europace, 14(6), 818\u2013825.","journal-title":"Europace"},{"key":"9685_CR4","volume":"3","author":"C Lafuente-Lafuente","year":"2015","unstructured":"Lafuente-Lafuente, C., Valembois, L., Bergmann, J. F., & Belmin, J. (2015). Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database of Systematic Reviews, 3, CD005049.","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8A","key":"9685_CR5","doi-asserted-by":"crossref","first-page":"2N","DOI":"10.1016\/S0002-9149(98)00583-9","volume":"82","author":"WB Kannel","year":"1998","unstructured":"Kannel, W. B., Wolf, P. A., Benjamin, E. J., & Levy, D. (1998). Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. The American Journal of Cardiology, 82(8A), 2N\u20139N.","journal-title":"The American Journal of Cardiology"},{"issue":"7","key":"9685_CR6","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1161\/01.CIR.96.7.2455","volume":"96","author":"BM Psaty","year":"1997","unstructured":"Psaty, B. M., Manolio, T. A., Kuller, L. H., et al. (1997). Incidence of and risk factors for atrial fibrillation in older adults. Circulation, 96(7), 2455\u20132461.","journal-title":"Circulation"},{"issue":"35","key":"9685_CR7","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/eurheartj\/eht194","volume":"34","author":"H Kottkamp","year":"2013","unstructured":"Kottkamp, H. (2013). Human atrial fibrillation substrate: towards a specific fibrotic atrial cardiomyopathy. European Heart Journal, 34(35), 2731\u20132738.","journal-title":"European Heart Journal"},{"issue":"11","key":"9685_CR8","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.jacc.2003.12.054","volume":"43","author":"K Nademanee","year":"2004","unstructured":"Nademanee, K., McKenzie, J., Kosar, E., et al. (2004). A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate. Journal of the American College of Cardiology, 43(11), 2044\u20132053.","journal-title":"Journal of the American College of Cardiology"},{"issue":"7","key":"9685_CR9","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jacc.2012.05.022","volume":"60","author":"SM Narayan","year":"2012","unstructured":"Narayan, S. M., Krummen, D. E., Shivkumar, K., Clopton, P., Rappel, W. J., & Miller, J. M. (2012). Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial. Journal of the American College of Cardiology, 60(7), 628\u2013636.","journal-title":"Journal of the American College of Cardiology"},{"issue":"Suppl 1","key":"9685_CR10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10840-005-2492-2","volume":"13","author":"BJ Scherlag","year":"2005","unstructured":"Scherlag, B. J., Nakagawa, H., Jackman, W. M., Yamanashi, W. S., Patterson, E., Po, S., & Lazzara, R. (2005). Electrical stimulation to identify neural elements on the heart: their role in atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 13(Suppl 1), 37\u201342.11.","journal-title":"Journal of Interventional Cardiac Electrophysiology"},{"issue":"6","key":"9685_CR11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCEP.109.910125","volume":"3","author":"MA Allessie","year":"2010","unstructured":"Allessie, M. A., de Groot, N. M., Houben, R. P., Schotten, U., Boersma, E., Smeets, J. L., & Crijns, H. J. (2010). Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation. Circulation. Arrhythmia and Electrophysiology, 3(6), 606\u2013615.","journal-title":"Circulation. Arrhythmia and Electrophysiology"},{"issue":"17","key":"9685_CR12","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/CIRCULATIONAHA.109.910901","volume":"122","author":"NM Groot de","year":"2010","unstructured":"de Groot, N. M., Houben, R. P., Smeets, J. L., et al. (2010). Electropathological substrate of longstanding persistent atrial fibrillation in patients with structural heart disease: epicardial breakthrough. Circulation, 122(17), 1674\u20131682.","journal-title":"Circulation"},{"issue":"3","key":"9685_CR13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10840-015-0061-x","volume":"44","author":"A Yaksh","year":"2015","unstructured":"Yaksh, A., van der Does, L. J., Kik, C., et al. (2015). A novel intra-operative, high-resolution atrial mapping approach. Journal of Interventional Cardiac Electrophysiology, 44(3), 221\u2013225.","journal-title":"Journal of Interventional Cardiac Electrophysiology"},{"issue":"6","key":"9685_CR14","first-page":"259","volume":"22","author":"A Yaksh","year":"2014","unstructured":"Yaksh, A., Kik, C., Knops, P., et al. (2014). Atrial fibrillation: to map or not to map? Netherlands Heart Journal, 22(6), 259\u2013266.","journal-title":"Netherlands Heart Journal"},{"issue":"2","key":"9685_CR15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0008-6363(00)00177-2","volume":"48","author":"J Chen","year":"2000","unstructured":"Chen, J., Mandapati, R., Berenfeld, O., Skanes, A. C., Gray, R. A., & Jalife, J. (2000). Dynamics of wavelets and their role in atrial fibrillation in the isolated sheep heart. Cardiovascular Research, 48(2), 220\u2013232.","journal-title":"Cardiovascular Research"},{"issue":"4","key":"9685_CR16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1540-8159.2008.01014.x","volume":"31","author":"P Kanagaratnam","year":"2008","unstructured":"Kanagaratnam, P., Kojodjojo, P., & Peters, N. S. (2008). Electrophysiological abnormalities occur prior to the development of clinical episodes of atrial fibrillation: observations from human epicardial mapping. Pacing and Clinical Electrophysiology, 31(4), 443\u2013453.","journal-title":"Pacing and Clinical Electrophysiology"},{"issue":"2","key":"9685_CR17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/eurheartj\/eht267","volume":"35","author":"G Lee","year":"2014","unstructured":"Lee, G., Kumar, S., Teh, A., et al. (2014). Epicardial wave mapping in human long-lasting persistent atrial fibrillation: transient rotational circuits, complex wavefronts, and disorganized activity. European Heart Journal, 35(2), 86\u201397.","journal-title":"European Heart Journal"},{"issue":"3","key":"9685_CR18","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jtcvs.2003.05.001","volume":"127","author":"T Nitta","year":"2004","unstructured":"Nitta, T., Ishii, Y., Miyagi, Y., Ohmori, H., Sakamoto, S., & Tanaka, S. (2004). Concurrent multiple left atrial focal activations with fibrillatory conduction and right atrial focal or reentrant activation as the mechanism in atrial fibrillation. The Journal of Thoracic and Cardiovascular Surgery, 127(3), 770\u2013778.","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"6","key":"9685_CR19","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/S0003-4975(96)00613-3","volume":"62","author":"T Sueda","year":"1996","unstructured":"Sueda, T., Nagata, H., Shikata, H., et al. (1996). Simple left atrial procedure for chronic atrial fibrillation associated with mitral valve disease. The Annals of Thoracic Surgery, 62(6), 1796\u20131800.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"5","key":"9685_CR20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/CIRCEP.113.000758","volume":"6","author":"MJ Campenhout van","year":"2013","unstructured":"van Campenhout, M. J., Yaksh, A., Kik, C., de Jaegere, P. P., Ho, S., Allessie, M. A., & de Groot, N. M. (2013). Bachmann\u2019s bundle: a key player in the development of atrial fibrillation? Circulation. Arrhythmia and Electrophysiology, 6(5), 1041\u20131046.","journal-title":"Circulation. Arrhythmia and Electrophysiology"},{"issue":"10","key":"9685_CR21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","volume":"339","author":"M Haissaguerre","year":"1998","unstructured":"Haissaguerre, M., Jais, P., Shah, D. C., et al. (1998). Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. The New England Journal of Medicine, 339(10), 659\u2013666.","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"9685_CR22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-8703(59)90274-1","volume":"58","author":"GK Moe","year":"1959","unstructured":"Moe, G. K., & Abildskov, J. A. (1959). Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. American Heart Journal, 58(1), 59\u201370.","journal-title":"American Heart Journal"},{"issue":"3","key":"9685_CR23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10840-014-9889-8","volume":"40","author":"T Baykaner","year":"2014","unstructured":"Baykaner, T., Lalani, G. G., Schricker, A., Krummun, D. E., & Narayen, S. M. (2014). Mapping and ablating stable sources for atrial fibrillation: summary of the literature on Focal Impulse and Rotor Modulation (FIRM). Journal of Interventional Cardiac Electrophysiology, 40(3), 237\u2013244.","journal-title":"Journal of Interventional Cardiac Electrophysiology"},{"issue":"4","key":"9685_CR24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/hrt.2003.015347","volume":"90","author":"A Boldt","year":"2004","unstructured":"Boldt, A., Wetzel, U., Lauschke, J., et al. (2004). Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease. Heart, 90(4), 400\u2013405.","journal-title":"Heart"},{"issue":"1","key":"9685_CR25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2013.08.083","volume":"169","author":"SH Wu","year":"2013","unstructured":"Wu, S. H., Jiang, W. F., Gu, J., et al. (2013). Benefits and risks of additional ablation of complex fractionated atrial electrograms for patients with atrial fibrillation: a systematic review and meta-analysis. International Journal of Cardiology, 169(1), 35\u201343.","journal-title":"International Journal of Cardiology"},{"issue":"1","key":"9685_CR26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1540-8167.2006.00620.x","volume":"18","author":"F Ravelli","year":"2007","unstructured":"Ravelli, F., Mase, M., Del Greco, M., Faes, L., & Disertori, M. (2007). Deterioration of organization in the first minutes of atrial fibrillation: a beat-to-beat analysis of cycle length and wave similarity. Journal of Cardiovascular Electrophysiology, 18(1), 60\u201365.","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"24","key":"9685_CR27","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1161\/01.CIR.0000130645.95357.97","volume":"109","author":"M Haissaguerre","year":"2004","unstructured":"Haissaguerre, M., Sanders, P., Hocini, M., et al. (2004). Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome. Circulation, 109(24), 3007\u20133013.","journal-title":"Circulation"},{"issue":"10","key":"9685_CR28","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1161\/01.CIR.96.10.3484","volume":"96","author":"FX Roithinger","year":"1997","unstructured":"Roithinger, F. X., Karch, M. R., Steiner, P. R., SippensGroenewegen, A., & Lesh, M. D. (1997). Relationship between atrial fibrillation and typical atrial flutter in humans: activation sequence changes during spontaneous conversion. Circulation, 96(10), 3484\u20133491.","journal-title":"Circulation"},{"issue":"4","key":"9685_CR29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1053\/eupc.1999.0054","volume":"1","author":"M Holm","year":"1999","unstructured":"Holm, M., Johansson, R., Smideberg, B., L\u00fchrs, C., & Olsson, S. B. (1999). Effect of cardiac exposure by median sternotomy on atrial fibrillation cycle length. Europace, 1(4), 248\u2013257.","journal-title":"Europace"},{"issue":"2","key":"9685_CR30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCEP.113.000342","volume":"6","author":"J Eckstein","year":"2013","unstructured":"Eckstein, J., Zeemering, S., Linz, D., et al. (2013). Transmural conduction is the predominant mechanism of breakthrough during atrial fibrillation: evidence from simultaneous endo-epicardial high-density activation mapping. Circulation. Arrhythmia and Electrophysiology, 6(2), 334\u2013341.","journal-title":"Circulation. Arrhythmia and Electrophysiology"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-016-9685-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-016-9685-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-016-9685-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:15:03Z","timestamp":1553613303000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-016-9685-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["9685"],"URL":"https:\/\/doi.org\/10.1007\/s12265-016-9685-1","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}