{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:15:40Z","timestamp":1778933740947,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL072936"],"award-info":[{"award-number":["HL072936"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL074091"],"award-info":[{"award-number":["HL074091"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL094414"],"award-info":[{"award-number":["HL094414"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F32 HL126300"],"award-info":[{"award-number":["F32 HL126300"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R56 HL131782"],"award-info":[{"award-number":["R56 HL131782"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16GRNT27790094"],"award-info":[{"award-number":["16GRNT27790094"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","award":["DGE-1247392"],"award-info":[{"award-number":["DGE-1247392"]}],"id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s12265-016-9716-y","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T09:18:26Z","timestamp":1477905506000},"page":"432-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart"],"prefix":"10.1007","volume":"9","author":[{"given":"Bryana M.","family":"Levitan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet R.","family":"Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine N.","family":"Withers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Andres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent L.","family":"Sorrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-8349","authenticated-orcid":false,"given":"Jonathan","family":"Satin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"issue":"12","key":"9716_CR1","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","volume":"372","author":"DC Rockey","year":"2015","unstructured":"Rockey, D. C., Bell, P. D., & Hill, J. A. (2015). Fibrosis\u2014a common pathway to organ injury and failure. New England Journal of Medicine, 372(12), 1138\u20131149. doi: 10.1056\/NEJMra1300575 .","journal-title":"New England Journal of Medicine"},{"issue":"25","key":"9716_CR2","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.107.707257","volume":"116","author":"L Chang","year":"2007","unstructured":"Chang, L., Zhang, J., Tseng, Y. H., Xie, C. Q., Ilany, J., Bruning, J. C., et al. (2007). Rad GTPase deficiency leads to cardiac hypertrophy. Circulation, 116(25), 2976\u20132983. doi: 10.1161\/CIRCULATIONAHA.107.707257 .","journal-title":"Circulation"},{"issue":"8","key":"9716_CR3","doi-asserted-by":"publisher","first-page":"H1336","DOI":"10.1152\/ajpheart.00389.2015","volume":"309","author":"JR Manning","year":"2015","unstructured":"Manning, J. R., Withers, C. N., Levitan, B., Smith, J. D., Andres, D. A., & Satin, J. (2015). Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging. American Journal of Physiology - Heart and Circulatory Physiology, 309(8), H1336\u2013H1345. doi: 10.1152\/ajpheart.00389.2015 .","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"key":"9716_CR4","doi-asserted-by":"crossref","unstructured":"Manning, J. R., Yin, G., Kaminski, C. N., Magyar, J., Feng, H. Z., Penn, J., et al. (2013). Rad GTPase deletion increases L-type Calcium channel current leading to increased cardiac contraction. Journal of the American Heart Association, 2(6), doi:10.1161\/jaha.113.000459.","DOI":"10.1161\/JAHA.113.000459"},{"issue":"2","key":"9716_CR5","doi-asserted-by":"publisher","first-page":"C379","DOI":"10.1152\/ajpcell.00270.2005","volume":"290","author":"TJ Hawke","year":"2006","unstructured":"Hawke, T. J., Kanatous, S. B., Martin, C. M., Goetsch, S. C., & Garry, D. J. (2006). Rad is temporally regulated within myogenic progenitor cells during skeletal muscle regeneration. American Journal of Physiology - Cell Physiology, 290(2), C379\u2013C387. doi: 10.1152\/ajpcell.00270.2005 .","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"9716_CR6","doi-asserted-by":"publisher","first-page":"14469","DOI":"10.1073\/pnas.2437756100","volume":"100","author":"BS Finlin","year":"2003","unstructured":"Finlin, B. S., Crump, S. M., Satin, J., & Andres, D. A. (2003). Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. PNAS, 100, 14469\u201314474. doi: 10.1073\/pnas.2437756100 .","journal-title":"PNAS"},{"issue":"2","key":"9716_CR7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1161\/CIRCRESAHA.109.208272","volume":"106","author":"G Wang","year":"2010","unstructured":"Wang, G., Zhu, X., Xie, W., Han, P., Li, K., Sun, Z., et al. (2010). Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circulation Research, 106(2), 317\u2013327. doi: 10.1161\/CIRCRESAHA.109.208272 .","journal-title":"Circulation Research"},{"key":"9716_CR8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/cvr\/cvr068","volume":"91","author":"J Zhang","year":"2011","unstructured":"Zhang, J., Chang, L., Chen, C., Zhang, M., Luo, Y., Hamblin, M., et al. (2011). Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. [Journal Article]. Cardiovascular Research, 91, 90\u201398. doi: 10.1093\/cvr\/cvr068 .","journal-title":"Cardiovascular Research"},{"key":"9716_CR9","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.yjmcc.2015.12.001","volume":"90","author":"DL Shepherd","year":"2016","unstructured":"Shepherd, D. L., Nichols, C. E., Croston, T. L., McLaughlin, S. L., Petrone, A. B., Lewis, S. E., et al. (2016). Early detection of cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging. Journal of Molecular and Cellular Cardiology, 90, 74\u201383. doi: 10.1016\/j.yjmcc.2015.12.001 .","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"1","key":"9716_CR10","doi-asserted-by":"publisher","first-page":"H88","DOI":"10.1152\/ajpheart.00642.2013","volume":"306","author":"SJ Shah","year":"2014","unstructured":"Shah, S. J., Aistrup, G. L., Gupta, D. K., O\u2019Toole, M. J., Nahhas, A. F., Schuster, D., et al. (2014). Ultrastructural and cellular basis for the development of abnormal myocardial mechanics during the transition from hypertension to heart failure. American Journal of Physiology. Heart and Circulatory Physiology, 306(1), H88\u2013100. doi: 10.1152\/ajpheart.00642.2013 .","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"1","key":"9716_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1161\/CIRCRESAHA.106.146399","volume":"101","author":"H Yada","year":"2007","unstructured":"Yada, H., Murata, M., Shimoda, K., Yuasa, S., Kawaguchi, H., Ieda, M., et al. (2007). Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart. Circulation Research, 101(1), 69\u201377. doi: 10.1161\/CIRCRESAHA.106.146399 .","journal-title":"Circulation Research"},{"issue":"5","key":"9716_CR12","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/acel.12109","volume":"12","author":"JM Flynn","year":"2013","unstructured":"Flynn, J. M., O\u2019Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B. J., et al. (2013). Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell, 12(5), 851\u2013862. doi: 10.1111\/acel.12109 .","journal-title":"Aging Cell"},{"issue":"2","key":"9716_CR13","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1249\/01.mss.0000183179.86594.4f","volume":"38","author":"SR Davidson","year":"2006","unstructured":"Davidson, S. R., Burnett, M., & Hoffman-Goetz, L. (2006). Training effects in mice after long-term voluntary exercise. Medicine and Science in Sports and Exercise, 38(2), 250\u2013255. doi: 10.1249\/01.mss.0000183179.86594.4f .","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"3","key":"9716_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ejechocard\/jer021","volume":"12","author":"V Mor-Avi","year":"2011","unstructured":"Mor-Avi, V., Lang, R. M., Badano, L. P., Belohlavek, M., Cardim, N. M., Derumeaux, G., et al. (2011). Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE\/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. European Heart Journal - Cardiovascular Imaging, 12(3), 167\u2013205. doi: 10.1093\/ejechocard\/jer021 .","journal-title":"European Heart Journal - Cardiovascular Imaging"},{"issue":"1","key":"9716_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1085\/jgp.201511484","volume":"147","author":"F Kobirumaki-Shimozawa","year":"2016","unstructured":"Kobirumaki-Shimozawa, F., Oyama, K., Shimozawa, T., Mizuno, A., Ohki, T., Terui, T., et al. (2016). Nano-imaging of the beating mouse heart in vivo: importance of sarcomere dynamics, as opposed to sarcomere length per se, in the regulation of cardiac function. The Journal of General Physiology, 147(1), 53\u201362. doi: 10.1085\/jgp.201511484 .","journal-title":"The Journal of General Physiology"},{"issue":"5138","key":"9716_CR16","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1126\/science.8248782","volume":"262","author":"C Reynet","year":"1993","unstructured":"Reynet, C., & Kahn, C. R. (1993). Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science, 262(5138), 1441\u20131444.","journal-title":"Science"},{"issue":"6","key":"9716_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1161\/circheartfailure.109.881326","volume":"2","author":"M Guazzi","year":"2009","unstructured":"Guazzi, M., Dickstein, K., Vicenzi, M., & Arena, R. (2009). Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights. Circulation. Heart Failure, 2(6), 549\u2013555. doi: 10.1161\/circheartfailure.109.881326 .","journal-title":"Circulation. Heart Failure"},{"issue":"21","key":"9716_CR18","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1161\/circulationaha.106.684357","volume":"116","author":"B Bijnens","year":"2007","unstructured":"Bijnens, B., Claus, P., Weidemann, F., Strotmann, J., & Sutherland, G. R. (2007). Investigating cardiac function using motion and deformation analysis in the setting of coronary artery disease. Circulation, 116(21), 2453\u20132464. doi: 10.1161\/circulationaha.106.684357 .","journal-title":"Circulation"},{"issue":"2","key":"9716_CR19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ahj.2009.05.031","volume":"158","author":"JL Hare","year":"2009","unstructured":"Hare, J. L., Brown, J. K., Leano, R., Jenkins, C., Woodward, N., & Marwick, T. H. (2009). Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab. American Heart Journal, 158(2), 294\u2013301. doi: 10.1016\/j.ahj.2009.05.031 .","journal-title":"American Heart Journal"},{"issue":"1","key":"9716_CR20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1093\/ejechocard\/jen166","volume":"10","author":"T Nishikage","year":"2009","unstructured":"Nishikage, T., Nakai, H., Mor-Avi, V., Lang, R. M., Salgo, I. S., Settlemier, S. H., et al. (2009). Quantitative assessment of left ventricular volume and ejection fraction using two-dimensional speckle tracking echocardiography. European Heart Journal - Cardiovascular Imaging, 10(1), 82\u201388. doi: 10.1093\/ejechocard\/jen166 .","journal-title":"European Heart Journal - Cardiovascular Imaging"},{"issue":"8","key":"9716_CR21","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1161\/CIRCRESAHA.110.239574","volume":"108","author":"M Bauer","year":"2011","unstructured":"Bauer, M., Cheng, S., Jain, M., Ngoy, S., Theodoropoulos, C., Trujillo, A., et al. (2011). Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circulation Research, 108(8), 908\u2013916. doi: 10.1161\/CIRCRESAHA.110.239574 .","journal-title":"Circulation Research"},{"key":"9716_CR22","doi-asserted-by":"crossref","unstructured":"Yamada, S., Arrell, D. K., Kane, G. C., Nelson, T. J., Perez\u2010Terzic, C. M., Behfar, A., et al. (2013). Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K+ channel\u2013deficient dilated cardiomyopathy. Journal of the American Heart Association, 2(6), doi:10.1161\/jaha.113.000410.","DOI":"10.1161\/JAHA.113.000410"},{"issue":"1","key":"9716_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12968-015-0180-7","volume":"17","author":"CM Haggerty","year":"2015","unstructured":"Haggerty, C. M., Mattingly, A. C., Kramer, S. P., Binkley, C. M., Jing, L., Suever, J. D., et al. (2015). Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance study. [journal article]. Journal of Cardiovascular Magnetic Resonance, 17(1), 1\u201314. doi: 10.1186\/s12968-015-0180-7 .","journal-title":"Journal of Cardiovascular Magnetic Resonance"},{"key":"9716_CR24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00553.2013","author":"A Bhan","year":"2014","unstructured":"Bhan, A., Sirker, A., Zhang, J., Protti, A., Catibog, N., Driver, W., et al. (2014). High frequency speckle tracking echocardiography in the assessment of left ventricular function after murine myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology. doi: 10.1152\/ajpheart.00553.2013 .","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"issue":"2","key":"9716_CR25","doi-asserted-by":"publisher","first-page":"H811","DOI":"10.1152\/ajpheart.00385.2009","volume":"297","author":"Y Peng","year":"2009","unstructured":"Peng, Y., Popovi\u0107, Z. B., Sopko, N., Drinko, J., Zhang, Z., Thomas, J. D., et al. (2009). Speckle tracking echocardiography in the assessment of mouse models of cardiac dysfunction. American Journal of Physiology - Heart and Circulatory Physiology, 297(2), H811\u2013H820. doi: 10.1152\/ajpheart.00385.2009 .","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"issue":"1","key":"9716_CR26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrm3495","volume":"14","author":"M Maillet","year":"2013","unstructured":"Maillet, M., van Berlo, J. H., & Molkentin, J. D. (2013). Molecular basis of physiological heart growth: fundamental concepts and new players. [ 10.1038\/nrm3495 ]. Nature Reviews. Molecular Cell Biology, 14(1), 38\u201348.","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"1","key":"9716_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1172\/JCI62839","volume":"123","author":"JH Berlo van","year":"2013","unstructured":"van Berlo, J. H., Maillet, M., & Molkentin, J. D. (2013). Signaling effectors underlying pathologic growth and remodeling of the heart. The Journal of Clinical Investigation, 123(1), 37\u201345. doi: 10.1172\/JCI62839 .","journal-title":"The Journal of Clinical Investigation"},{"issue":"31","key":"9716_CR28","doi-asserted-by":"crossref","first-page":"21503","DOI":"10.1074\/jbc.274.31.21503","volume":"274","author":"JN Muth","year":"1999","unstructured":"Muth, J. N., Yamaguchi, H., Mikala, G., Grupp, I. L., Lewis, W., Cheng, H., et al. (1999). Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction.PG - 21503\u20136. The Journal of Biological Chemistry, 274(31), 21503\u201321506.","journal-title":"The Journal of Biological Chemistry"},{"issue":"50","key":"9716_CR29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.yjmcc.2010.11.012","volume":"50","author":"X Chen","year":"2011","unstructured":"Chen, X., Nakayama, H., Zhang, X., Ai, X., Harris, D. M., Tang, M., et al. (2011). Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of Molecular and Cellular Cardiology, 50(50), 460\u2013470. doi: 10.1016\/j.yjmcc.2010.11.012 .","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"2","key":"9716_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cmet.2015.01.005","volume":"21","author":"PA Gorski","year":"2015","unstructured":"Gorski, P. A., Ceholski, D. K., & Hajjar, R. J. (2015). Altered myocardial calcium cycling and energetics in heart failure\u2014a rational approach for disease treatment. Cell Metabolism, 21(2), 183\u2013194. doi: 10.1016\/j.cmet.2015.01.005 .","journal-title":"Cell Metabolism"},{"issue":"3","key":"9716_CR31","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/s0008-6363(01)00210-3","volume":"50","author":"U Wisl\u00f8ff","year":"2001","unstructured":"Wisl\u00f8ff, U., Loennechen, J. P., Falck, G., Beisvag, V., Currie, S., Smith, G., et al. (2001). Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats. Cardiovascular Research, 50(3), 495\u2013508. doi: 10.1016\/s0008-6363(01)00210-3 .","journal-title":"Cardiovascular Research"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-016-9716-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-016-9716-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-016-9716-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:26:43Z","timestamp":1498343203000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-016-9716-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":31,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["9716"],"URL":"https:\/\/doi.org\/10.1007\/s12265-016-9716-y","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}