{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:58:06Z","timestamp":1769263086183,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/1-24\/12-NCD-II"],"award-info":[{"award-number":["5\/4\/1-24\/12-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s12265-018-9808-y","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T12:17:06Z","timestamp":1525263426000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of Sodium Thiosulfate Postconditioning on Ischemia-Reperfusion Injury Induced Mitochondrial Dysfunction in Rat Heart"],"prefix":"10.1007","volume":"11","author":[{"given":"Sriram","family":"Ravindran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-2399","authenticated-orcid":false,"given":"Gino A.","family":"Kurian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"issue":"1","key":"9808_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy, D. J., & Yellon, D. M. (2013). Myocardial ischemia-reperfusion injury: a neglected therapeutic target. The Journal of Clinical Investigation, 123(1), 92\u2013100. https:\/\/doi.org\/10.1172\/JCI62874 .","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"9808_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","volume":"111","author":"DJ Hausenloy","year":"2016","unstructured":"Hausenloy, D. J., Barrabes, J. A., Botker, H. E., Davidson, S. M., Di Lisa, F., Downey, J., et al. (2016). Ischaemic conditioning and targeting reperfusion injury: a 30\u00a0year voyage of discovery. Basic Research in Cardiology, 111(6), 70. https:\/\/doi.org\/10.1007\/s00395-016-0588-8 .","journal-title":"Basic Research in Cardiology"},{"issue":"9","key":"9808_CR3","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1161\/CIRCRESAHA.112.265660","volume":"111","author":"AM Walters","year":"2012","unstructured":"Walters, A. M., Porter, G. A., & Brookes, P. S. (2012). Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circulation Research, 111(9), 1222\u20131236. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.265660 .","journal-title":"Circulation Research"},{"issue":"4","key":"9808_CR4","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.carpath.2016.04.005","volume":"25","author":"S Ravindran","year":"2016","unstructured":"Ravindran, S., Ansari Banu, S., & Kurian, G. A. (2016). Hydrogen sulfide preconditioning shows differential protection towards interfibrillar and subsarcolemmal mitochondria from isolated rat heart subjected to revascularization injury. Cardiovascular Pathology, 25(4), 306\u2013315. https:\/\/doi.org\/10.1016\/j.carpath.2016.04.005 .","journal-title":"Cardiovascular Pathology"},{"issue":"4","key":"9808_CR5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s12192-016-0682-8","volume":"21","author":"SA Banu","year":"2016","unstructured":"Banu, S. A., Ravindran, S., & Kurian, G. A. (2016). Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury. Cell Stress & Chaperones, 21(4), 571\u2013582. https:\/\/doi.org\/10.1007\/s12192-016-0682-8 .","journal-title":"Cell Stress & Chaperones"},{"key":"9808_CR6","doi-asserted-by":"publisher","unstructured":"Marutani, E., Yamada, M., Ida, T., Tokuda, K., Ikeda, K., Kai, S., et al. (2015). Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia. Journal of the American Heart Association, 4(11). https:\/\/doi.org\/10.1161\/JAHA.115.002125 .","DOI":"10.1161\/JAHA.115.002125"},{"key":"9808_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cbi.2017.07.002","volume":"274","author":"S Ravindran","year":"2017","unstructured":"Ravindran, S., Jahir Hussain, S., Boovarahan, S. R., & Kurian, G. A. (2017). Sodium thiosulfate post-conditioning protects rat hearts against ischemia reperfusion injury via reduction of apoptosis and oxidative stress. Chemico-Biological Interactions, 274, 24\u201334. https:\/\/doi.org\/10.1016\/j.cbi.2017.07.002 .","journal-title":"Chemico-Biological Interactions"},{"issue":"1","key":"9808_CR8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000380945","volume":"5","author":"Z Yu","year":"2015","unstructured":"Yu, Z., Gu, L., Pang, H., Fang, Y., Yan, H., & Fang, W. (2015). Sodium thiosulfate: an emerging treatment for calciphylaxis in dialysis patients. Case Reports in Nephrology and Dialysis, 5(1), 77\u201382. https:\/\/doi.org\/10.1159\/000380945 .","journal-title":"Case Reports in Nephrology and Dialysis"},{"key":"9808_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neuint.2015.09.004","volume":"90","author":"N Subhash","year":"2015","unstructured":"Subhash, N., Sriram, R., & Kurian, G. A. (2015). Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification. Neurochemistry International, 90, 193\u2013203. https:\/\/doi.org\/10.1016\/j.neuint.2015.09.004 .","journal-title":"Neurochemistry International"},{"issue":"5","key":"9808_CR10","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.nefro.2016.05.003","volume":"36","author":"JA Martin Navarro","year":"2016","unstructured":"Martin Navarro, J. A., Pedraza Cezon, L. A., de Pablos Martin, M. P., Gonzalez Monte, E., Polanco Fernandez, N., Gutierrez Sanchez, M. J., et al. (2016). Treatment with sodium thiosulfate in calciphylaxis of topical active renal transplant patient. Nefrolog\u00eda, 36(5), 579\u2013581. https:\/\/doi.org\/10.1016\/j.nefro.2016.05.003 .","journal-title":"Nefrolog\u00eda"},{"issue":"6","key":"9808_CR11","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1590\/S1677-5538.IBJU.2014.0585","volume":"41","author":"N Baldev","year":"2015","unstructured":"Baldev, N., Sriram, R., Prabu, P. C., & Kurian Gino, A. (2015). Effect of mitochondrial potassium channel on the renal protection mediated by sodium thiosulfate against ethylene glycol induced nephrolithiasis in rat model. International Braz J Urol, 41(6), 1116\u20131125. https:\/\/doi.org\/10.1590\/S1677-5538.IBJU.2014.0585 .","journal-title":"International Braz J Urol"},{"key":"9808_CR12","doi-asserted-by":"publisher","unstructured":"Ravindran, S., Boovarahan, S. R., Shanmugam, K., Vedarathinam, R. C., & Kurian, G. A. (2017). Sodium thiosulfate preconditioning ameliorates ischemia\/reperfusion injury in rat hearts via reduction of oxidative stress and apoptosis. Cardiovascular Drugs and Therapy. https:\/\/doi.org\/10.1007\/s10557-017-6751-0 .","DOI":"10.1007\/s10557-017-6751-0"},{"issue":"1","key":"9808_CR13","first-page":"1","volume":"11","author":"AS Manning","year":"1980","unstructured":"Manning, A. S., Hearse, D. J., Dennis, S. C., Bullock, G. R., & Coltart, D. J. (1980). Myocardial ischaemia: an isolated, globally perfused rat heart model for metabolic and pharmacological studies. European Journal of Cardiology, 11(1), 1\u201321.","journal-title":"European Journal of Cardiology"},{"issue":"2","key":"9808_CR14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0005-2744(67)90146-5","volume":"132","author":"IA Bolotina","year":"1967","unstructured":"Bolotina, I. A., Markovich, D. S., Volkenstein, M. V., & Zavodzky, P. (1967). Investigation of the conformation of lactate dehydrogenase and of its catalytic activity. Biochimica et Biophysica Acta, 132(2), 271\u2013281.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"9808_CR15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0021-9258(18)49235-6","volume":"205","author":"DE Koshland Jr","year":"1953","unstructured":"Koshland Jr., D. E., & Clarke, E. (1953). Mechanism of hydrolysis of adenosine triphosphate catalyzed by lobster muscle. The Journal of Biological Chemistry, 205(2), 917\u2013924.","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"9808_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/BF00269099","volume":"99","author":"B Holmbom","year":"1993","unstructured":"Holmbom, B., Naslund, U., Eriksson, A., Virtanen, I., & Thornell, L. E. (1993). Comparison of triphenyltetrazolium chloride (TTC) staining versus detection of fibronectin in experimental myocardial infarction. Histochemistry, 99(4), 265\u2013275.","journal-title":"Histochemistry"},{"issue":"23","key":"9808_CR17","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1016\/S0021-9258(19)75283-1","volume":"252","author":"JW Palmer","year":"1977","unstructured":"Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977). Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. The Journal of Biological Chemistry, 252(23), 8731\u20138739.","journal-title":"The Journal of Biological Chemistry"},{"issue":"1\u20132","key":"9808_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0006-8993(02)03767-8","volume":"960","author":"T Kobayashi","year":"2003","unstructured":"Kobayashi, T., Kuroda, S., Tada, M., Houkin, K., Iwasaki, Y., & Abe, H. (2003). Calcium-induced mitochondrial swelling and cytochrome c release in the brain: Its biochemical characteristics and implication in ischemic neuronal injury. Brain Research, 960(1\u20132), 62\u201370.","journal-title":"Brain Research"},{"issue":"1 Pt 1","key":"9808_CR19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","volume":"76","author":"RC Scaduto","year":"1999","unstructured":"Scaduto, R. C., & Grotyohann, L. W. (1999). Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophysical Journal, 76(1 Pt 1), 469\u2013477.","journal-title":"Biophysical Journal"},{"key":"9808_CR20","doi-asserted-by":"publisher","unstructured":"Barrientos, A., Fontanesi, F., & D\u00edaz, F. (2009). Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays. In J. L. Haines et al. (Eds.), Current protocols in human genetics. CHAPTER, Unit19.13-Unit19.13. https:\/\/doi.org\/10.1002\/0471142905.hg1903s63 .","DOI":"10.1002\/0471142905.hg1903s63"},{"issue":"2","key":"9808_CR21","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95(2), 351\u2013358.","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"9808_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak, J., & Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Analytical Biochemistry, 25(1), 192\u2013205.","journal-title":"Analytical Biochemistry"},{"issue":"3","key":"9808_CR23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF02712155","volume":"13","author":"A Nandi","year":"1988","unstructured":"Nandi, A., & Chatterjee, I. B. (1988). Assay of superoxide dismutase activity in animal tissues. [journal article]. Journal of Biosciences, 13(3), 305\u2013315. https:\/\/doi.org\/10.1007\/bf02712155 .","journal-title":"Journal of Biosciences"},{"issue":"2","key":"9808_CR24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0021-9258(18)56216-5","volume":"187","author":"SA Goldblith","year":"1950","unstructured":"Goldblith, S. A., & Proctor, B. E. (1950). Photometric determination of catalase activity. The Journal of Biological Chemistry, 187(2), 705\u2013709.","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"9808_CR25","first-page":"175","volume":"17","author":"S Bitny-Szlachto","year":"1970","unstructured":"Bitny-Szlachto, S., & Sollich, A. (1970). The estimation of oxidized and reduced NADP by an enzymic recycling system, with oxidized glutathione as hydrogen acceptor. Acta Biochimica Polonica, 17(3), 175\u2013184.","journal-title":"Acta Biochimica Polonica"},{"issue":"1","key":"9808_CR26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00795111","volume":"90","author":"GA Pantely","year":"1995","unstructured":"Pantely, G. A., & Bristow, J. D. (1995). Hibernating myocardium: a hypometabolic state for energy conservation. Basic Research in Cardiology, 90(1), 23\u201325.","journal-title":"Basic Research in Cardiology"},{"issue":"5","key":"9808_CR27","doi-asserted-by":"publisher","first-page":"R1297","DOI":"10.1152\/ajpregu.00260.2005","volume":"289","author":"YL Ma","year":"2005","unstructured":"Ma, Y. L., Zhu, X., Rivera, P. M., Toien, O., Barnes, B. M., LaManna, J. C., et al. (2005). Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 289(5), R1297\u2013R1306. https:\/\/doi.org\/10.1152\/ajpregu.00260.2005 .","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"issue":"7","key":"9808_CR28","doi-asserted-by":"publisher","first-page":"e21971","DOI":"10.1371\/journal.pone.0021971","volume":"6","author":"C Yang","year":"2011","unstructured":"Yang, C., Yang, Z., Zhang, M., Dong, Q., Wang, X., Lan, A., et al. (2011). Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS\/NF-\u03baB\/COX-2 pathway. PLoS One, 6(7), e21971. https:\/\/doi.org\/10.1371\/journal.pone.0021971 .","journal-title":"PLoS One"},{"issue":"1","key":"9808_CR29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1091\/mbc.e09-03-0199","volume":"21","author":"MW Budde","year":"2010","unstructured":"Budde, M. W., & Roth, M. B. (2010). Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel\u2013Lindau tumor suppressor-1 in C. elegans. Molecular Biology of the Cell, 21(1), 212\u2013217. https:\/\/doi.org\/10.1091\/mbc.E09-03-0199 .","journal-title":"Molecular Biology of the Cell"},{"issue":"12","key":"9808_CR30","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1139\/Y07-120","volume":"85","author":"Z Zhang","year":"2007","unstructured":"Zhang, Z., Huang, H., Liu, P., Tang, C., & Wang, J. (2007). Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. Canadian Journal of Physiology and Pharmacology, 85(12), 1248\u20131253. https:\/\/doi.org\/10.1139\/Y07-120 .","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"11","key":"9808_CR31","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"C Szabo","year":"2007","unstructured":"Szabo, C. (2007). Hydrogen sulphide and its therapeutic potential. Nature Reviews. Drug Discovery, 6(11), 917\u2013935. https:\/\/doi.org\/10.1038\/nrd2425 .","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"8","key":"9808_CR32","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1111\/bph.12369","volume":"171","author":"C Szabo","year":"2014","unstructured":"Szabo, C., Ransy, C., M\u00f3dis, K., Andriamihaja, M., Murghes, B., Coletta, C., et al. (2014). Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms. British Journal of Pharmacology, 171(8), 2099\u20132122. https:\/\/doi.org\/10.1111\/bph.12369 .","journal-title":"British Journal of Pharmacology"},{"issue":"7\u20138","key":"9808_CR33","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/prca.201400052","volume":"8","author":"LE Smith","year":"2014","unstructured":"Smith, L. E., & White, M. Y. (2014). The role of post-translational modifications in acute and chronic cardiovascular disease. Proteomics. Clinical Applications, 8(7\u20138), 506\u2013521. https:\/\/doi.org\/10.1002\/prca.201400052 .","journal-title":"Proteomics. Clinical Applications"},{"issue":"3","key":"9808_CR34","first-page":"237","volume":"2","author":"JBW Weiss","year":"2012","unstructured":"Weiss, J. B. W., Eisenhardt, S. U., Stark, G. B., Bode, C., Moser, M., & Grundmann, S. (2012). MicroRNAs in ischemia-reperfusion injury. American Journal of Cardiovascular Disease, 2(3), 237\u2013247.","journal-title":"American Journal of Cardiovascular Disease"},{"issue":"3","key":"9808_CR35","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3390\/cells3030883","volume":"3","author":"M Kataoka","year":"2014","unstructured":"Kataoka, M., & Wang, D.-Z. (2014). Non-coding RNAs including miRNAs and lncRNAs in cardiovascular biology and disease. Cell, 3(3), 883\u2013898. https:\/\/doi.org\/10.3390\/cells3030883 .","journal-title":"Cell"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-018-9808-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-018-9808-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-018-9808-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T15:19:31Z","timestamp":1661095171000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-018-9808-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["9808"],"URL":"https:\/\/doi.org\/10.1007\/s12265-018-9808-y","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]},"assertion":[{"value":"31 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All institutional ethical guidelines and national guidelines for the care and use of laboratory animals were followed and approved by the institutional animal ethics committee at SASTRA Deemed University (IAEC No. 229\/IAEC\/RPP). No human studies were carried out for this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}