{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:47:16Z","timestamp":1789948036706,"version":"4.0.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO311"],"award-info":[{"award-number":["KFO311"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EraNet","award":["Expert"],"award-info":[{"award-number":["Expert"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12265-019-09880-7","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T14:18:32Z","timestamp":1551881912000},"page":"447-458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-2883","authenticated-orcid":false,"given":"Jan","family":"Fiedler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hobu\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnian Kalbasi","family":"Anaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Pfanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Mitzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Dumler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Weidemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Hilfiker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"9880_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.pcad.2014.02.006","volume":"56","author":"JJ Thaden","year":"2014","unstructured":"Thaden, J. J., Nkomo, V. T., & Enriquez-Sarano, M. (2014). The global burden of aortic stenosis. Progress in Cardiovascular Diseases, 56, 565\u2013571.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"9880_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1161\/CIRCRESAHA.113.300156","volume":"113","author":"BA Carabello","year":"2013","unstructured":"Carabello, B. A. (2013). Introduction to aortic stenosis. Circulation Research, 113, 179\u2013185.","journal-title":"Circulation Research"},{"key":"9880_CR3","first-page":"284","volume":"20","author":"DS Bach","year":"2011","unstructured":"Bach, D. S. (2011). Prevalence and characteristics of unoperated patients with severe aortic stenosis. The Journal of Heart Valve Disease, 20, 284\u2013291.","journal-title":"The Journal of Heart Valve Disease"},{"key":"9880_CR4","first-page":"137","volume":"6","author":"SJ Park","year":"2013","unstructured":"Park, S. J., Enriquez-Sarano, M., Chang, S. A., Choi, J. O., Lee, S. C., Park, S. W., Kim, D. K., Jeon, E. S., & Oh, J. K. (2013). Hemodynamic patterns for symptomatic presentations of severe aortic stenosis. JACC: Cardiovascular Imaging, 6, 137\u2013146.","journal-title":"JACC: Cardiovascular Imaging"},{"key":"9880_CR5","unstructured":"Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Jr., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O\u2019Gara, P. T., O\u2019Rourke, R. A., Otto, C. M., Shah, P. M., Shanewise, J. S., & American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. (2008). 2008 focused update incorporated into the ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American heart association task force on practice guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the society of cardiovascular anesthesiologists, society for cardiovascular angiography and interventions, and society of thoracic surgeons. Journal of the American College of Cardiology, 52, e1\u2013e142."},{"key":"9880_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005). Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell., 120, 15\u201320.","journal-title":"Cell."},{"key":"9880_CR7","unstructured":"Sheehan D, Hrapchak B (1980) Theory and practice of histotechnology. Battelle Press, Ohio; 2nd Ed: 226\u2013227."},{"key":"9880_CR8","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/nature07511","volume":"456","author":"T Thum","year":"2008","unstructured":"Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., Castoldi, M., Soutschek, J., Koteliansky, V., Rosenwald, A., Basson, M. A., Licht, J. D., Pena, J. T., Rouhanifard, S. H., Muckenthaler, M. U., Tuschl, T., Martin, G. R., Bauersachs, J., & Engelhardt, S. (2008). MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature, 456, 980\u2013984.","journal-title":"Nature"},{"key":"9880_CR9","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.111.039008","volume":"124","author":"J Fiedler","year":"2011","unstructured":"Fiedler, J., Jazbutyte, V., Kirchmaier, B. C., Gupta, S. K., Lorenzen, J., Hartmann, D., Galuppo, P., Kneitz, S., Pena, J. T., Sohn-Lee, C., Loyer, X., Soutschek, J., Brand, T., Tuschl, T., Heineke, J., Martin, U., Schulte-Merker, S., Ertl, G., Engelhardt, S., Bauersachs, J., & Thum, T. (2011). MicroRNA-24 regulates vascularity after myocardial infarction. Circulation, 124, 720\u2013730.","journal-title":"Circulation"},{"key":"9880_CR10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nature08195","volume":"460","author":"KR Cordes","year":"2009","unstructured":"Cordes, K. R., Sheehy, N. T., White, M. P., Berry, E. C., Morton, S. U., Muth, A. N., Lee, T. H., Miano, J. M., Ivey, K. N., & Srivastava, D. (2009). miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature., 460, 705\u2013710.","journal-title":"Nature."},{"key":"9880_CR11","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1172\/JCI38864","volume":"119","author":"T Boettger","year":"2009","unstructured":"Boettger, T., Beetz, N., Kostin, S., Schneider, J., Kruger, M., Hein, L., & Braun, T. (2009). Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143\/145 gene cluster. The Journal of Clinical Investigation, 119, 2634\u20132647.","journal-title":"The Journal of Clinical Investigation"},{"key":"9880_CR12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/386078a0","volume":"386","author":"G Luo","year":"1997","unstructured":"Luo, G., Ducy, P., McKee, M. D., Pinero, G. J., Loyer, E., Behringer, R. R., & Karsenty, G. (1997). Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature., 386, 78\u201381.","journal-title":"Nature."},{"key":"9880_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.stem.2016.10.005","volume":"20","author":"ICL Pillai","year":"2017","unstructured":"Pillai, I. C. L., Li, S., Romay, M., Lam, L., Lu, Y., Huang, J., Dillard, N., Zemanova, M., Rubbi, L., Wang, Y., Lee, J., Xia, M., Liang, O., Xie, Y. H., Pellegrini, M., Lusis, A. J., & Deb, A. (2017). Cardiac fibroblasts adopt osteogenic fates and can be targeted to attenuate pathological heart calcification. Cell Stem Cell, 20, 218\u2013232.e5.","journal-title":"Cell Stem Cell"},{"key":"9880_CR14","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.111.051052","volume":"125","author":"MR Dweck","year":"2012","unstructured":"Dweck, M. R., Jones, C., Joshi, N. V., Fletcher, A. M., Richardson, H., White, A., Marsden, M., Pessotto, R., Clark, J. C., Wallace, W. A., Salter, D. M., McKillop, G., van Beek, E. J., Boon, N. A., Rudd, J. H., & Newby, D. E. (2012). Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis. Circulation, 125, 76\u201386.","journal-title":"Circulation"},{"key":"9880_CR15","doi-asserted-by":"publisher","first-page":"8657","DOI":"10.1074\/jbc.M117.783308","volume":"292","author":"R Song","year":"2017","unstructured":"Song, R., Fullerton, D. A., Ao, L., Zhao, K. S., & Meng, X. (2017). An epigenetic regulatory loop controls pro-osteogenic activation by TGF-beta1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. The Journal of Biological Chemistry, 292, 8657\u20138666.","journal-title":"The Journal of Biological Chemistry"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-019-09880-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12265-019-09880-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-019-09880-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:18:38Z","timestamp":1583367518000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12265-019-09880-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,6]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["9880"],"URL":"https:\/\/doi.org\/10.1007\/s12265-019-09880-7","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,6]]},"assertion":[{"value":"15 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors disclose support from DFG (KFO311 to TT) and EraNet Expert (to TT). TT and JF have filed patents in the field of cardiovascular miRNA diagnostics and therapeutics. TT is founder of Cardior Pharmaceuticals GmbH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study. Aortic valve samples were obtained from patients undergoing aortic valve replacement in the University Hospital W\u00fcrzburg approved by ethics committee (study number 111\/03 from 09\/2003).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Subjects\/Informed Consent Statement"}}]}}