{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:43:57Z","timestamp":1740149037548,"version":"3.37.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s12265-020-09967-6","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:02:31Z","timestamp":1588957351000},"page":"184-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-4028","authenticated-orcid":false,"given":"Ajay Godwin","family":"Potnuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingesh","family":"Allakonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin","family":"Saheera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"issue":"19","key":"9967_CR1","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","volume":"54","author":"F Triposkiadis","year":"2009","unstructured":"Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J. (2009). The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. Journal of the American College of Cardiology, 54(19), 1747\u20131762. https:\/\/doi.org\/10.1016\/j.jacc.2009.05.015.","journal-title":"Journal of the American College of Cardiology"},{"issue":"2","key":"9967_CR2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","volume":"123","author":"KE Porter","year":"2009","unstructured":"Porter, K. E., & Turner, N. A. (2009). Cardiac fibroblasts: At the heart of myocardial remodeling. Pharmacology & Therapeutics, 123(2), 255\u2013278. https:\/\/doi.org\/10.1016\/j.pharmthera.2009.05.002.","journal-title":"Pharmacology & Therapeutics"},{"issue":"20","key":"9967_CR3","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1161\/01.CIR.101.20.2431","volume":"101","author":"HW Lim","year":"2000","unstructured":"Lim, H. W., Windt, L. J. D., Steinberg, L., Taigen, T., Witt, S. A., Kimball, T. R., & Molkentin, J. D. (2000). Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation, 101(20), 2431\u20132437. https:\/\/doi.org\/10.1161\/01.CIR.101.20.2431.","journal-title":"Circulation"},{"issue":"10","key":"9967_CR4","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1529\/biophysj.107.110031","volume":"93","author":"M Cooling","year":"2007","unstructured":"Cooling, M., Hunter, P., & Crampin, E. J. (2007). Modeling hypertrophic IP3 transients in the cardiac Myocyte. Biophysical Journal, 93(10), 3421\u20133433. https:\/\/doi.org\/10.1529\/biophysj.107.110031.","journal-title":"Biophysical Journal"},{"issue":"15","key":"9967_CR5","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1161\/01.CIR.97.15.1488","volume":"97","author":"Y Sakata","year":"1998","unstructured":"Sakata, Y., Hoit, B. D., Liggett, S. B., Walsh, R. A., & Dorn, G. W. (1998). Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation, 97(15), 1488\u20131495.","journal-title":"Circulation"},{"issue":"8","key":"9967_CR6","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1161\/01.CIR.97.8.744","volume":"97","author":"K P\u00f6nicke","year":"1998","unstructured":"P\u00f6nicke, K., Vogelsang, M., Heinroth, M., Becker, K., Zolk, O., B\u00f6hm, M., et al. (1998). Endothelin receptors in the failing and nonfailing human heart. Circulation, 97(8), 744\u2013751.","journal-title":"Circulation"},{"issue":"41","key":"9967_CR7","doi-asserted-by":"publisher","first-page":"25562","DOI":"10.1016\/S0021-9258(18)47286-9","volume":"269","author":"WA Clark","year":"1994","unstructured":"Clark, W. A., Rudnick, S. J., Andersen, L. C., & LaPres, J. J. (1994). Myosin heavy chain synthesis is independently regulated in hypertrophy and atrophy of isolated adult cardiac myocytes. The Journal of Biological Chemistry, 269(41), 25562\u201325569.","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"9967_CR8","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1161\/01.RES.73.6.1163","volume":"73","author":"WA Clark","year":"1993","unstructured":"Clark, W. A., Rudnick, S. J., LaPres, J. J., Andersen, L. C., & LaPointe, M. C. (1993). Regulation of hypertrophy and atrophy in cultured adult heart cells. Circulation Research, 73(6), 1163\u20131176.","journal-title":"Circulation Research"},{"issue":"3 Pt 2","key":"9967_CR9","first-page":"H953","volume":"260","author":"U Ikeda","year":"1991","unstructured":"Ikeda, U., Tsuruya, Y., & Yaginuma, T. (1991). Alpha 1-adrenergic stimulation is coupled to cardiac myocyte hypertrophy. The American Journal of Physiology, 260(3 Pt 2), H953\u2013H956.","journal-title":"The American Journal of Physiology"},{"issue":"3","key":"9967_CR10","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1042\/bj2660727","volume":"266","author":"SJ Fuller","year":"1990","unstructured":"Fuller, S. J., Gaitanaki, C. J., & Sugden, P. H. (1990). Effects of catecholamines on protein synthesis in cardiac myocytes and perfused hearts isolated from adult rats. Stimulation of translation is mediated through the alpha 1-adrenoceptor. The Biochemical Journal, 266(3), 727\u2013736.","journal-title":"The Biochemical Journal"},{"issue":"12","key":"9967_CR11","doi-asserted-by":"publisher","first-page":"7759","DOI":"10.1016\/S0021-9258(20)89515-5","volume":"266","author":"KU Knowlton","year":"1991","unstructured":"Knowlton, K. U., Baracchini, E., Ross, R. S., Harris, A. N., Henderson, S. A., Evans, S. M., et al. (1991). Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. The Journal of Biological Chemistry, 266(12), 7759\u20137768.","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"9967_CR12","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1172\/JCI113179","volume":"80","author":"NH Bishopric","year":"1987","unstructured":"Bishopric, N. H., Simpson, P. C., & Ordahl, C. P. (1987). Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. The Journal of Clinical Investigation, 80(4), 1194\u20131199. https:\/\/doi.org\/10.1172\/JCI113179.","journal-title":"The Journal of Clinical Investigation"},{"issue":"35","key":"9967_CR13","doi-asserted-by":"publisher","first-page":"26658","DOI":"10.1016\/S0021-9258(19)74362-2","volume":"268","author":"K Kariya","year":"1993","unstructured":"Kariya, K., Farrance, I. K., & Simpson, P. C. (1993). Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. The Journal of Biological Chemistry, 268(35), 26658\u201326662.","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"9967_CR14","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1172\/JCI113951","volume":"83","author":"CS Long","year":"1989","unstructured":"Long, C. S., Ordahl, C. P., & Simpson, P. C. (1989). Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. The Journal of Clinical Investigation, 83(3), 1078\u20131082. https:\/\/doi.org\/10.1172\/JCI113951.","journal-title":"The Journal of Clinical Investigation"},{"issue":"8","key":"9967_CR15","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1136\/hrt.2005.068270","volume":"93","author":"M Seddon","year":"2007","unstructured":"Seddon, M., Looi, Y. H., & Shah, A. M. (2007). Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart, 93(8), 903\u2013907. https:\/\/doi.org\/10.1136\/hrt.2005.068270.","journal-title":"Heart"},{"issue":"Pt 16","key":"9967_CR16","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1242\/jeb.00483","volume":"206","author":"C Gaitanaki","year":"2003","unstructured":"Gaitanaki, C., Konstantina, S., Chrysa, S., & Beis, I. (2003). Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart. The Journal of Experimental Biology, 206(Pt 16), 2759\u20132769.","journal-title":"The Journal of Experimental Biology"},{"issue":"8","key":"9967_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke, J., & Molkentin, J. D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature reviews. Molecular and Cellular Biology, 7(8), 589\u2013600. https:\/\/doi.org\/10.1038\/nrm1983.","journal-title":"Molecular and Cellular Biology"},{"key":"9967_CR18","doi-asserted-by":"publisher","first-page":"e997","DOI":"10.1038\/cddis.2013.533","volume":"5","author":"H He","year":"2014","unstructured":"He, H., Liu, X., Lv, L., Liang, H., Leng, B., Zhao, D., et al. (2014). Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress. Cell Death & Disease, 5, e997. https:\/\/doi.org\/10.1038\/cddis.2013.533.","journal-title":"Cell Death & Disease"},{"issue":"2","key":"9967_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1161\/01.HYP.0000254415.31362.a7","volume":"49","author":"E Takimoto","year":"2007","unstructured":"Takimoto, E., & Kass, D. A. (2007). Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension, 49(2), 241\u2013248. https:\/\/doi.org\/10.1161\/01.HYP.0000254415.31362.a7.","journal-title":"Hypertension"},{"issue":"5","key":"9967_CR20","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1111\/j.1476-5381.2010.01043.x","volume":"162","author":"Q Xu","year":"2011","unstructured":"Xu, Q., Dalic, A., Fang, L., Kiriazis, H., Ritchie, R., Sim, K., et al. (2011). Myocardial oxidative stress contributes to transgenic \u03b22-adrenoceptor activation-induced cardiomyopathy and heart failure. British Journal of Pharmacology, 162(5), 1012\u20131028. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01043.x.","journal-title":"British Journal of Pharmacology"},{"issue":"5","key":"9967_CR21","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1111\/j.1476-5381.2010.01130.x","volume":"162","author":"F Di Lisa","year":"2011","unstructured":"Di Lisa, F., Kaludercic, N., & Paolocci, N. (2011). \u03b22\u2013Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another \u201cradical\u201d road to heart failure? British Journal of Pharmacology, 162(5), 1009\u20131011. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01130.x.","journal-title":"British Journal of Pharmacology"},{"issue":"4","key":"9967_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0891-5849(90)90002-Z","volume":"9","author":"GR Haenen","year":"1990","unstructured":"Haenen, G. R., Veerman, M., & Bast, A. (1990). Reduction of beta-adrenoceptor function by oxidative stress in the heart. Free Radical Biology & Medicine, 9(4), 279\u2013288.","journal-title":"Free Radical Biology & Medicine"},{"issue":"3","key":"9967_CR23","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1084\/jem.20002036","volume":"195","author":"M Hara","year":"2002","unstructured":"Hara, M., Ono, K., Hwang, M.-W., Iwasaki, A., Okada, M., Nakatani, K., et al. (2002). Evidence for a role of mast cells in the evolution to congestive heart failure. The Journal of Experimental Medicine, 195(3), 375\u2013381.","journal-title":"The Journal of Experimental Medicine"},{"issue":"15","key":"9967_CR24","first-page":"969","volume":"315","author":"AM Dvorak","year":"1986","unstructured":"Dvorak, A. M. (1986). Mast-cell degranulation in human hearts. The New England Journal of Medicine, 315(15), 969\u2013970.","journal-title":"The New England Journal of Medicine"},{"issue":"3","key":"9967_CR25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00395-013-0342-4","volume":"108","author":"T Luo","year":"2013","unstructured":"Luo, T., Chen, B., Zhao, Z., He, N., Zeng, Z., Wu, B., et al. (2013). Histamine H2 receptor activation exacerbates myocardial ischemia\/reperfusion injury by disturbing mitochondrial and endothelial function. Basic Research in Cardiology, 108(3), 342. https:\/\/doi.org\/10.1007\/s00395-013-0342-4.","journal-title":"Basic Research in Cardiology"},{"issue":"7","key":"9967_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1042\/CS20130716","volume":"127","author":"Z Zeng","year":"2014","unstructured":"Zeng, Z., Shen, L., Li, X., Luo, T., Wei, X., Zhang, J., et al. (2014). Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Clinical Science (London, England : 1979), 127(7), 435\u2013448. https:\/\/doi.org\/10.1042\/CS20130716.","journal-title":"Clinical Science (London, England : 1979)"},{"key":"9967_CR27","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ijcard.2015.10.040","volume":"202","author":"AG Potnuri","year":"2016","unstructured":"Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2016). Targeting histamine-2 receptor for prevention of cardiac remodelling in chronic pressure overload. International Journal of Cardiology, 202, 831\u2013833. https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.040.","journal-title":"International Journal of Cardiology"},{"issue":"6","key":"9967_CR28","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00395-010-0119-y","volume":"105","author":"H Takahama","year":"2010","unstructured":"Takahama, H., Asanuma, H., Sanada, S., Fujita, M., Sasaki, H., Wakeno, M., et al. (2010). A histamine H2 receptor blocker ameliorates development of heart failure in dogs independently of \u03b2-adrenergic receptor blockade. Basic Research in Cardiology, 105(6), 787\u2013794. https:\/\/doi.org\/10.1007\/s00395-010-0119-y.","journal-title":"Basic Research in Cardiology"},{"issue":"1","key":"9967_CR29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1472-8206.2009.00810.x","volume":"25","author":"A Ahmadi","year":"2011","unstructured":"Ahmadi, A., Ebrahimzadeh, M. A., Ahmad-Ashrafi, S., Karami, M., Mahdavi, M. R., & Saravi, S. S. S. (2011). Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. Fundamental & Clinical Pharmacology, 25(1), 72\u201379. https:\/\/doi.org\/10.1111\/j.1472-8206.2009.00810.x.","journal-title":"Fundamental & Clinical Pharmacology"},{"issue":"2","key":"9967_CR30","first-page":"221","volume":"58","author":"M Kesiova","year":"2006","unstructured":"Kesiova, M., Alexandrova, A., Yordanova, N., Kirkova, M., & Todorov, S. (2006). Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacological reports: PR, 58(2), 221\u2013228.","journal-title":"Pharmacological reports: PR"},{"issue":"1","key":"9967_CR31","first-page":"32","volume":"65","author":"FF Herman","year":"1990","unstructured":"Herman, F. F., Goldberg, B. J., Lad, P. M., Neidzin, H., Kaplan, M., & Easton, J. G. (1990). Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects. Annals of Allergy, 65(1), 32\u201336.","journal-title":"Annals of Allergy"},{"issue":"1\u20132","key":"9967_CR32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0006-8993(94)90007-8","volume":"643","author":"RA Rius","year":"1994","unstructured":"Rius, R. A., Mollner, S., Pfeuffer, T., & Peng Loh, Y. (1994). Developmental changes in Gs and golf proteins and adenylyl cyclases in mouse brain membranes. Brain Research, 643(1\u20132), 50\u201358. https:\/\/doi.org\/10.1016\/0006-8993(94)90007-8.","journal-title":"Brain Research"},{"issue":"3","key":"9967_CR33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0891-5849(88)90023-8","volume":"4","author":"CG Fraga","year":"1988","unstructured":"Fraga, C. G., Leibovitz, B. E., & Tappel, A. L. (1988). Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radical Biology and Medicine, 4(3), 155\u2013161. https:\/\/doi.org\/10.1016\/0891-5849(88)90023-8.","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"9967_CR34","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nprot.2009.197","volume":"5","author":"CJ Weydert","year":"2010","unstructured":"Weydert, C. J., & Cullen, J. J. (2010). Measurement of superoxide dismutase, catalase, and glutathione peroxidase in cultured cells and tissue. Nature Protocols, 5(1), 51\u201366. https:\/\/doi.org\/10.1038\/nprot.2009.197.","journal-title":"Nature Protocols"},{"key":"9967_CR35","doi-asserted-by":"publisher","unstructured":"Li, R., Jen, N., Yu, F., & Hsiai, T. K. (2011). Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Current protocols in cytometry\/editorial board, J. Paul Robinson, managing editor ... [et al.], CHAPTER, Unit9.37. doi:https:\/\/doi.org\/10.1002\/0471142956.cy0937s58.","DOI":"10.1002\/0471142956.cy0937s58"},{"key":"9967_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","volume":"594","author":"E Eruslanov","year":"2010","unstructured":"Eruslanov, E., & Kusmartsev, S. (2010). Identification of ROS using oxidized DCFDA and flow-cytometry. Methods in Molecular Biology (Clifton, N.J.), 594, 57\u201372. https:\/\/doi.org\/10.1007\/978-1-60761-411-1_4.","journal-title":"Methods in Molecular Biology (Clifton, N.J.)"},{"issue":"8","key":"9967_CR37","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1172\/JCI11273","volume":"107","author":"JW Knowles","year":"2001","unstructured":"Knowles, J. W., Esposito, G., Mao, L., Hagaman, J. R., Fox, J. E., Smithies, O., et al. (2001). Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A\u2013deficient mice. Journal of Clinical Investigation, 107(8), 975\u2013984.","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"9967_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/jhh.2014.36","volume":"29","author":"W Nadruz","year":"2015","unstructured":"Nadruz, W. (2015). Myocardial remodeling in hypertension. Journal of Human Hypertension, 29(1), 1\u20136. https:\/\/doi.org\/10.1038\/jhh.2014.36.","journal-title":"Journal of Human Hypertension"},{"issue":"3","key":"9967_CR39","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/j.1476-5381.2011.01355.x","volume":"164","author":"H Aceros","year":"2011","unstructured":"Aceros, H., Farah, G., Cobos-Puc, L., Stabile, A., Noiseux, N., & Mukaddam-Daher, S. (2011). Moxonidine improves cardiac structure and performance in SHR through inhibition of cytokines, p38 MAPK and Akt. British Journal of Pharmacology, 164(3), 946\u2013957. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01355.x.","journal-title":"British Journal of Pharmacology"},{"issue":"12","key":"9967_CR40","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41440-018-0109-2","volume":"41","author":"AG Potnuri","year":"2018","unstructured":"Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2018). Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 41(12), 1023\u20131035. https:\/\/doi.org\/10.1038\/s41440-018-0109-2.","journal-title":"Hypertension Research: Official Journal of the Japanese Society of Hypertension"},{"issue":"7","key":"9967_CR41","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.jacc.2006.05.069","volume":"48","author":"J Kim","year":"2006","unstructured":"Kim, J., Ogai, A., Nakatani, S., Hashimura, K., Kanzaki, H., Komamura, K., et al. (2006). Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies. Journal of the American College of Cardiology, 48(7), 1378\u20131384. https:\/\/doi.org\/10.1016\/j.jacc.2006.05.069.","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"9967_CR42","doi-asserted-by":"publisher","first-page":"492","DOI":"10.4103\/0253-7613.84947","volume":"43","author":"G Khilnani","year":"2011","unstructured":"Khilnani, G., & Khilnani, A. K. (2011). Inverse agonism and its therapeutic significance. Indian Journal of Pharmacology, 43(5), 492\u2013501. https:\/\/doi.org\/10.4103\/0253-7613.84947.","journal-title":"Indian Journal of Pharmacology"},{"issue":"1\u20132","key":"9967_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s10787-006-1516-6","volume":"14","author":"F Monczor","year":"2006","unstructured":"Monczor, F. (2006). Mechanisms of inverse agonism at histamine H(2) receptors - potential benefits and concerns. Inflammopharmacology, 14(1\u20132), 89\u201396. https:\/\/doi.org\/10.1007\/s10787-006-1516-6.","journal-title":"Inflammopharmacology"},{"issue":"6","key":"9967_CR44","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1124\/mol.64.6.1357","volume":"64","author":"JG Baker","year":"2003","unstructured":"Baker, J. G., Hall, I. P., & Hill, S. J. (2003). Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Molecular Pharmacology, 64(6), 1357\u20131369. https:\/\/doi.org\/10.1124\/mol.64.6.1357.","journal-title":"Molecular Pharmacology"},{"key":"9967_CR45","doi-asserted-by":"publisher","first-page":"001212","DOI":"10.1161\/CIRCULATIONAHA.112.001212","volume":"113","author":"L Lai","year":"2013","unstructured":"Lai, L., Yan, L., Gao, S., Hu, C.-L., Ge, H., Davidow, A., et al. (2013). Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1\/FoxO3a pathway. Circulation, CIRCULATIONAHA, 113, 001212. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.001212.","journal-title":"Circulation, CIRCULATIONAHA"},{"issue":"14","key":"9967_CR46","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1161\/CIRCULATIONAHA.105.582239","volume":"113","author":"S Matsushima","year":"2006","unstructured":"Matsushima, S., Ide, T., Yamato, M., Matsusaka, H., Hattori, F., Ikeuchi, M., et al. (2006). Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation, 113(14), 1779\u20131786. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.582239.","journal-title":"Circulation"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-020-09967-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-020-09967-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-020-09967-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:52:08Z","timestamp":1620435128000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-020-09967-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["9967"],"URL":"https:\/\/doi.org\/10.1007\/s12265-020-09967-6","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"type":"print","value":"1937-5387"},{"type":"electronic","value":"1937-5395"}],"subject":[],"published":{"date-parts":[[2020,5,8]]},"assertion":[{"value":"12 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study did not involve any human or animal subject. Hence, statements on Human and Animal Rights and an Informed Consent do not apply.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statements on Human and Animal Rights and an Informed Consent"}}]}}