{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:59:03Z","timestamp":1786982343030,"version":"build-2736575974"},"reference-count":154,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3455"],"award-info":[{"award-number":["2018JJ3455"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ2341"],"award-info":[{"award-number":["2018JJ2341"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40249"],"award-info":[{"award-number":["2019JJ40249"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970390"],"award-info":[{"award-number":["81970390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060065"],"award-info":[{"award-number":["82060065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470569"],"award-info":[{"award-number":["81470569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970390, 82060065"],"award-info":[{"award-number":["81970390, 82060065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Foundation for Guangxi Key Laboratory of Diabetic Systems Medicine","award":["20-065-77"],"award-info":[{"award-number":["20-065-77"]}]},{"name":"Outstanding Young Aid Program for Education Department of Hunan Province","award":["18B274"],"award-info":[{"award-number":["18B274"]}]},{"name":"Major Project of social science achievement review committee in Hunan Province","award":["XSP20ZDI013"],"award-info":[{"award-number":["XSP20ZDI013"]}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["CX20200965"],"award-info":[{"award-number":["CX20200965"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2020GXNSFDA297011"],"award-info":[{"award-number":["2020GXNSFDA297011"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Foundation for Guangxi Key Laboratory of Diabetic Systems Medicine","award":["20-065-77"],"award-info":[{"award-number":["20-065-77"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12265-021-10108-w","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T11:03:05Z","timestamp":1614250985000},"page":"857-872","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-7632","authenticated-orcid":false,"given":"Ye-shi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-ping","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Nov\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"10108_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1053\/j.seminhematol.2015.04.003","volume":"52","author":"TK Kim","year":"2015","unstructured":"Kim, T. K., Gore, S. D., & Zeidan, A. M. (2015). Epigenetic therapy in acute myeloid leukemia: current and future directions. Seminars in Hematology, 52, 172\u2013183.","journal-title":"Seminars in Hematology"},{"key":"10108_CR2","first-page":"1957","volume":"8","author":"X Wu","year":"2018","unstructured":"Wu, X., Sang, L., & Gong, Y. (2018). N6-methyladenine RNA modification and cancers. American Journal of Cancer Research, 8, 1957\u20131966.","journal-title":"American Journal of Cancer Research"},{"key":"10108_CR3","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","volume":"169","author":"IA Roundtree","year":"2017","unstructured":"Roundtree, I. A., Evans, M. E., Pan, T., & He, C. (2017). Dynamic RNA modifications in gene expression regulation. Cell, 169, 1187\u20131200.","journal-title":"Cell"},{"key":"10108_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/255028a0","volume":"255","author":"JM Adams","year":"1975","unstructured":"Adams, J. M., & Cory, S. (1975). Modified nucleosides and bizarre 5\u2019-termini in mouse myeloma mRNA. Nature, 255, 28\u201333.","journal-title":"Nature"},{"key":"10108_CR5","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","volume":"71","author":"R Desrosiers","year":"1974","unstructured":"Desrosiers, R., Friderici, K., & Rottman, F. (1974). Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America, 71, 3971\u20133975.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10108_CR6","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1093\/nar\/gky130","volume":"46","author":"D Yang","year":"2018","unstructured":"Yang, D., Qiao, J., Wang, G., Lan, Y., Li, G., Guo, X., et al. (2018). N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential. Nucleic Acids Research, 46(8), 3906\u20133920.","journal-title":"Nucleic Acids Research"},{"issue":"7544","key":"10108_CR7","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nature14281","volume":"519","author":"CR Alarc\u00f3n","year":"2015","unstructured":"Alarc\u00f3n, C. R., Lee, H., Goodarzi, H., Halberg, N., & Tavazoie, S. F. (2015). N6-methyladenosine marks primary microRNAs for processing. Nature, 519(7544), 482\u2013485.","journal-title":"Nature"},{"issue":"1","key":"10108_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.molcel.2019.07.016","volume":"76","author":"YG Chen","year":"2019","unstructured":"Chen, Y. G., Chen, R., Ahmad, S., Verma, R., Kasturi, S. P., Amaya, L., et al. (2019). N6-methyladenosine modification controls circular rna immunity. Molecular Cell, 76(1), 96\u2013109.","journal-title":"Molecular Cell"},{"key":"10108_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tig.2012.11.003","volume":"29","author":"G Jia","year":"2013","unstructured":"Jia, G., Fu, Y., & He, C. (2013). Reversible RNA adenosine methylation in biological regulation. Trends in Genetics, 29, 108\u2013115.","journal-title":"Trends in Genetics"},{"key":"10108_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","volume":"11","author":"Y Niu","year":"2013","unstructured":"Niu, Y., Zhao, X., Wu, Y. S., & Li, M. M. (2013). N6-methyl-adenosine (m6A) in RNA: an old modificatio with a novel epigenetic function. Genomics, Proteomics & Bioinformatics, 11, 8\u201317.","journal-title":"Genomics, Proteomics & Bioinformatics"},{"key":"10108_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.cell.2013.10.026","volume":"155","author":"JM Fustin","year":"2013","unstructured":"Fustin, J. M., Doi, M., Yamaguchi, Y., & Hida, H. (2013). RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell, 155, 793\u2013806.","journal-title":"Cell"},{"key":"10108_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang, X., Lu, Z., Gomez, A., & Hon, C. G. (2014). N6-methyladenosine-dependent regulation of messenger RNA stability. Nature, 505, 117\u2013120.","journal-title":"Nature"},{"key":"10108_CR13","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.cell.2013.10.047","volume":"155","author":"S Schwartz","year":"2013","unstructured":"Schwartz, S., Agarwala, S. D., Mumbach, M. R., & Jovanovic, M. (2013). High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell, 155, 1409\u20131421.","journal-title":"Cell"},{"key":"10108_CR14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","volume":"139","author":"LE Dorn","year":"2019","unstructured":"Dorn, L. E., Lasman, L., Chen, J., & Xu, X. (2019). The N(6)-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy. Circulation, 139, 533\u2013545.","journal-title":"Circulation"},{"key":"10108_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.26508\/lsa.201800233","volume":"2","author":"V Kmietczyk","year":"2019","unstructured":"Kmietczyk, V., Riechert, E., Kalinski, L., & Boileau, E. (2019). m(6)A-mRNA methylation regulates cardiac gene expression and cellular growth. Life Science Alliance, 2, 2.","journal-title":"Life Science Alliance"},{"key":"10108_CR16","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","volume":"139","author":"P Mathiyalagan","year":"2019","unstructured":"Mathiyalagan, P., Adamiak, M., Mayourian, J., & Sassi, Y. (2019). FTO-dependent N(6)-methyladenosine regulates cardiac function during remodeling and repair. Circulation, 139, 518\u2013532.","journal-title":"Circulation"},{"issue":"8","key":"10108_CR17","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","volume":"15","author":"H Song","year":"2019","unstructured":"Song, H., Feng, X., Zhang, H., Luo, Y., Huang, J., Lin, M., et al. (2019). METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes. Autophagy, 15(8), 1419\u20131437.","journal-title":"Autophagy"},{"issue":"5","key":"10108_CR18","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1021\/acs.biochem.8b01166","volume":"58","author":"DL Balacco","year":"2019","unstructured":"Balacco, D. L., & Soller, M. (2019). The m6A writer: rise of a machine for growing tasks. Biochemistry, 58(5), 363\u2013378.","journal-title":"Biochemistry"},{"issue":"6409","key":"10108_CR19","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1126\/science.aau1646","volume":"361","author":"M Frye","year":"2018","unstructured":"Frye, M., Harada, B. T., Behm, M., & He, C. (2018). RNA modifications modulate gene expression during development. Science, 361(6409), 1346\u20131349.","journal-title":"Science"},{"issue":"6225","key":"10108_CR20","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","volume":"347","author":"S Geula","year":"2015","unstructured":"Geula, S., Moshitch-Moshkovitz, S., Dominissini, D., Mansour, A. A., Kol, N., Salmon-Divon, M., et al. (2015). m6A mRNA methylation facilitates resolution of na\u00efve pluripotency toward differentiation. Science, 347(6225), 1002\u20131006.","journal-title":"Science"},{"issue":"1","key":"10108_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13059-018-1435-z","volume":"19","author":"C Ma","year":"2018","unstructured":"Ma, C., Chang, M., Lv, H., Zhang, Z. W., Zhang, W., He, X., et al. (2018). RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biology, 19(1), 68.","journal-title":"Genome Biology"},{"issue":"4","key":"10108_CR22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.cell.2017.09.003","volume":"171","author":"KJ Yoon","year":"2017","unstructured":"Yoon, K. J., Ringeling, F. R., Vissers, C., Jacob, F., Pokrass, M., Jimenez-Cyrus, D., et al. (2017). Temporal control of mammalian cortical neurogenesis by m6A methylation. Cell, 171(4), 877\u2013889.","journal-title":"Cell"},{"issue":"1","key":"10108_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1096\/fj.201800719R","volume":"33","author":"TG Meng","year":"2019","unstructured":"Meng, T. G., Lu, X., Guo, L., Hou, G. M., Ma, X. S., Li, Q. N., et al. (2019). Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. The FASEB Journal, 33(1), 1179\u20131187.","journal-title":"The FASEB Journal"},{"issue":"6","key":"10108_CR24","doi-asserted-by":"publisher","first-page":"887","DOI":"10.15252\/embr.201541970","volume":"17","author":"NT Tran","year":"2016","unstructured":"Tran, N. T., Su, H., Khodadadi-Jamayran, A., Lin, S., Zhang, L., Zhou, D., et al. (2016). The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation. EMBO Reports, 17(6), 887\u2013900.","journal-title":"EMBO Reports"},{"issue":"2","key":"10108_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1128\/MCB.00370-08","volume":"29","author":"GD Raffel","year":"2016","unstructured":"Raffel, G. D., Chu, G. C., Jesneck, J. L., Cullen, D. E., Bronson, R. T., Bernard, O. A., et al. (2016). Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Molecular and Cellular Biology, 29(2), 333\u2013341.","journal-title":"Molecular and Cellular Biology"},{"key":"10108_CR26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41421-018-0019-0","volume":"4","author":"Y Yue","year":"2018","unstructured":"Yue, Y., Liu, J., Cui, X., & Cao, J. (2018). VIRMA mediates preferential m(6)A mRNA methylation in 3\u2019UTR and near stop codon and associates with alternative polyadenylation. Cell Discovery, 4, 10.","journal-title":"Cell Discovery"},{"key":"10108_CR27","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","volume":"69","author":"J Wen","year":"2018","unstructured":"Wen, J., Lv, R., Ma, H., & Shen, H. (2018). Zc3h13 regulates nuclear RNA m(6)A methylation and mouse embryonic stem cell self-renewal. Molecular Cell, 69, 1028\u20131038.","journal-title":"Molecular Cell"},{"key":"10108_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","volume":"537","author":"DP Patil","year":"2016","unstructured":"Patil, D. P., Chen, C. K., & Pickering, B. F. A. (2016). Chow, m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature, 537, 369\u2013373.","journal-title":"Nature"},{"key":"10108_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu, J., Yue, Y., Han, D., & Wang, X. (2014). A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nature Chemical Biology, 10, 93\u2013105.","journal-title":"Nature Chemical Biology"},{"key":"10108_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.tig.2019.10.011","volume":"36","author":"H Huang","year":"2020","unstructured":"Huang, H., Weng, H., & Chen, J. (2020). The biogenesis and precise control of RNA m(6)A methylation. Trends in Genetics, 36, 44\u201352.","journal-title":"Trends in Genetics"},{"key":"10108_CR31","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41586-019-1016-7","volume":"567","author":"H Huang","year":"2019","unstructured":"Huang, H., Weng, H., Zhou, K., & Wu, T. (2019). Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature, 567, 414\u2013419.","journal-title":"Nature"},{"key":"10108_CR32","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/cr.2014.3","volume":"24","author":"XL Ping","year":"2014","unstructured":"Ping, X. L., Sun, B. F., Wang, L., & Xiao, W. (2014). Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Research, 24, 177\u2013189.","journal-title":"Cell Research"},{"key":"10108_CR33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ncb2902","volume":"16","author":"Y Wang","year":"2014","unstructured":"Wang, Y., Li, Y., Toth, J. I., & Petroski, M. D. (2014). N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature Cell Biology, 16, 191\u2013198.","journal-title":"Nature Cell Biology"},{"key":"10108_CR34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.celrep.2014.05.048","volume":"8","author":"S Schwartz","year":"2014","unstructured":"Schwartz, S., Mumbach, M. R., Jovanovic, M., & Wang, T. (2014). Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5\u2019 sites. Cell Reports, 8, 284\u2013296.","journal-title":"Cell Reports"},{"key":"10108_CR35","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.molcel.2018.08.004","volume":"71","author":"M Mendel","year":"2018","unstructured":"Mendel, M., Chen, K. M., Homolka, D., & Gos, P. (2018). Methylation of structured RNA by the m(6)A writer METTL16 is essential for mouse embryonic development. Molecular Cell, 71, 986\u20131000.","journal-title":"Molecular Cell"},{"key":"10108_CR36","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","volume":"169","author":"KE Pendleton","year":"2017","unstructured":"Pendleton, K. E., Chen, B., Liu, K., & Hunter, O. V. (2017). The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell, 169, 824\u2013835.","journal-title":"Cell"},{"key":"10108_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41589-018-0184-3","volume":"15","author":"H Ma","year":"2019","unstructured":"Ma, H., & Wang, X. (2019). N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology, 15, 88\u201394.","journal-title":"Nature Chemical Biology"},{"key":"10108_CR38","doi-asserted-by":"publisher","first-page":"7719","DOI":"10.1093\/nar\/gkz619","volume":"47","author":"T Nvan","year":"2019","unstructured":"Nvan, T., Ernst, F. G. M., Hawley, B. R., & Zorbas, C. (2019). The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Research, 47, 7719\u20137733.","journal-title":"Nucleic Acids Research"},{"key":"10108_CR39","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.15252\/embr.201744940","volume":"18","author":"AS Warda","year":"2017","unstructured":"Warda, A. S., Kretschmer, J., Hackert, P., & Lenz, C. (2017). Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Reports, 18, 2004\u20132014.","journal-title":"EMBO Reports"},{"key":"10108_CR40","doi-asserted-by":"crossref","unstructured":"Akichika, S., Hirano, S., & Shichino, Y. (2019). Cap-specific terminal N (6)-methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363(64213).","DOI":"10.1126\/science.aav0080"},{"key":"10108_CR41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41422-018-0117-4","volume":"29","author":"H Sun","year":"2019","unstructured":"Sun, H., Zhang, M., Li, K., & Bai, D. (2019). Cap-specific, terminal N(6)-methylation by a mammalian m(6)Am methyltransferase. Cell Research, 29, 80\u201382.","journal-title":"Cell Research"},{"key":"10108_CR42","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia, G., Fu, Y., Zhao, X., & Dai, Q. (2011). N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology, 7, 885\u2013887.","journal-title":"Nature Chemical Biology"},{"key":"10108_CR43","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1126\/science.1151710","volume":"318","author":"T Gerken","year":"2007","unstructured":"Gerken, T., Girard, C. A., Tung, Y. C., & Webby, C. J. (2007). The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science, 318, 1469\u20131472.","journal-title":"Science"},{"key":"10108_CR44","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature21022","volume":"541","author":"J Mauer","year":"2017","unstructured":"Mauer, J., Luo, X., Blanjoie, A., & Jiao, X. (2017). Reversible methylation of m(6)Am in the 5\u2019 cap controls mRNA stability. Nature, 541, 371\u2013375.","journal-title":"Nature"},{"key":"10108_CR45","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.febslet.2014.02.021","volume":"588","author":"W Chen","year":"2014","unstructured":"Chen, W., Zhang, L., Zheng, G., & Fu, Y. (2014). Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Letters, 588, 892\u2013898.","journal-title":"FEBS Letters"},{"key":"10108_CR46","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","volume":"49","author":"G Zheng","year":"2013","unstructured":"Zheng, G., Dahl, J. A., Niu, Y., & Fedorcsak, P. (2013). ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molecular Cell, 49, 18\u201329.","journal-title":"Molecular Cell"},{"key":"10108_CR47","doi-asserted-by":"publisher","first-page":"11571","DOI":"10.1074\/jbc.M113.546168","volume":"289","author":"C Feng","year":"2014","unstructured":"Feng, C., Liu, Y., Wang, G., & Deng, Z. (2014). Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. The Journal of Biological Chemistry, 289, 11571\u201311583.","journal-title":"The Journal of Biological Chemistry"},{"key":"10108_CR48","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang, X., Zhao, B. S., Roundtree, I. A., & Lu, Z. (2015). N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell, 161, 1388\u20131399.","journal-title":"Cell"},{"key":"10108_CR49","doi-asserted-by":"publisher","first-page":"12626","DOI":"10.1038\/ncomms12626","volume":"7","author":"H Du","year":"2016","unstructured":"Du, H., Zhao, Y., He, J., & Zhang, Y. (2016). YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nature Communications, 7, 12626.","journal-title":"Nature Communications"},{"key":"10108_CR50","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/cr.2017.15","volume":"27","author":"H Shi","year":"2017","unstructured":"Shi, H., Wang, X., Lu, Z., & Zhao, B. S. (2017). YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA. Cell Research, 27, 315\u2013328.","journal-title":"Cell Research"},{"key":"10108_CR51","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","volume":"163","author":"KD Meyer","year":"2015","unstructured":"Meyer, K. D., Patil, D. P., Zhou, J., & Zinoviev, A. (2015). 5\u2019 UTR m(6)A promotes Cap-independent translation. Cell, 163, 999\u20131010.","journal-title":"Cell"},{"key":"10108_CR52","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tig.2016.03.006","volume":"32","author":"IA Roundtree","year":"2016","unstructured":"Roundtree, I. A., & He, C. (2016). Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Trends in Genetics, 32, 320\u2013321.","journal-title":"Trends in Genetics"},{"key":"10108_CR53","doi-asserted-by":"crossref","unstructured":"Roundtree, I. A., Luo, G. Z., Zhang, Z., & Wang, X. (2017). YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs. Elife, 6.","DOI":"10.7554\/eLife.31311"},{"issue":"7540","key":"10108_CR54","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature14234","volume":"518","author":"N Liu","year":"2015","unstructured":"Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., & Pan, T. (2015). N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature, 518(7540), 560\u2013564.","journal-title":"Nature"},{"issue":"1","key":"10108_CR55","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.molcel.2019.07.005","volume":"76","author":"KI Zhou","year":"2019","unstructured":"Zhou, K. I., Shi, H., Lyu, R., Wylder, A. C., Matuszek, \u017b., Pan, J. N., et al. (2019). Regulation of co-transcriptional pre-mRNA splicing by m6A through the low-complexity protein hnRNPG. Molecular Cell, 76(1), 70\u201381.","journal-title":"Molecular Cell"},{"issue":"6","key":"10108_CR56","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","volume":"162","author":"CR Alarc\u00f3n","year":"2015","unstructured":"Alarc\u00f3n, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015). HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events. Cell., 162(6), 1299\u20131308.","journal-title":"Cell."},{"key":"10108_CR57","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","volume":"122","author":"I Kehat","year":"2010","unstructured":"Kehat, I., & Molkentin, J. D. (2010). Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation, 122, 2727\u20132735.","journal-title":"Circulation"},{"key":"10108_CR58","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/abbs\/gmw025","volume":"48","author":"L Li","year":"2016","unstructured":"Li, L., Xu, J., He, L., & Peng, L. (2016). The role of autophagy in cardiac hypertrophy. Acta Biochimica et Biophysica Sinica Shanghai, 48, 491\u2013500.","journal-title":"Acta Biochimica et Biophysica Sinica Shanghai"},{"key":"10108_CR59","doi-asserted-by":"crossref","unstructured":"Gan, X. T., Zhao, G., Huang, C. X., & Rowe, A. C. (2013). Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy. PLoS One, 8.","DOI":"10.1371\/journal.pone.0074235"},{"key":"10108_CR60","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","volume":"65","author":"NG Frangogiannis","year":"2019","unstructured":"Frangogiannis, N. G. (2019). Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities. Molecular Aspects of Medicine, 65, 70\u201399.","journal-title":"Molecular Aspects of Medicine"},{"issue":"15","key":"10108_CR61","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","volume":"71","author":"A Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez, A., Schelbert, E. B., D\u00edez, J., & Butler, J. (2018). Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. Journal of the American College of Cardiology, 71(15), 1696\u20131706.","journal-title":"Journal of the American College of Cardiology"},{"issue":"2","key":"10108_CR62","volume":"35","author":"T Li","year":"2021","unstructured":"Li, T., Zhuang, Y., Yang, W., Xie, Y., Shang, W., Su, S., et al. (2021). Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts. The FASEB Journal, 35(2), e21162.","journal-title":"The FASEB Journal"},{"key":"10108_CR63","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1172\/JCI82719","volume":"125","author":"PY Chen","year":"2015","unstructured":"Chen, P. Y., Qin, L., Baeyens, N., & Li, G. (2015). Endothelial-to-mesenchymal transition drives atherosclerosis progression. The Journal of Clinical Investigation, 125, 4514\u20134528.","journal-title":"The Journal of Clinical Investigation"},{"issue":"12","key":"10108_CR64","first-page":"7015","volume":"24","author":"BY Zhang","year":"2020","unstructured":"Zhang, B. Y., Han, L., Tang, Y. F., Zhang, G. X., Fan, X. L., Zhang, J. J., et al. (2020). METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion. European Review for Medical and Pharmacological Sciences, 24(12), 7015\u20137023.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"20","key":"10108_CR65","doi-asserted-by":"publisher","first-page":"8939","DOI":"10.7150\/thno.45178","volume":"10","author":"D Jian","year":"2020","unstructured":"Jian, D., Wang, Y., Jian, L., Tang, H., Rao, L., Chen, K., et al. (2020). METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications. Theranostics, 10(20), 8939\u20138956.","journal-title":"Theranostics"},{"key":"10108_CR66","doi-asserted-by":"publisher","first-page":"106800","DOI":"10.1016\/j.intimp.2020.106800","volume":"86","author":"M Guo","year":"2020","unstructured":"Guo, M., Yan, R., Ji, Q., Yao, H., Sun, M., Duan, L., et al. (2020). IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome. International Immunopharmacology, 86, 106800.","journal-title":"International Immunopharmacology"},{"key":"10108_CR67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.15420\/cfr.2016:25:2","volume":"3","author":"G Savarese","year":"2017","unstructured":"Savarese, G., & Lund, L. H. (2017). Global public health burden of heart failure. Cardiac Failure Review, 3, 7\u201311.","journal-title":"Cardiac Failure Review"},{"key":"10108_CR68","first-page":"62","volume":"106","author":"PS Azevedo","year":"2016","unstructured":"Azevedo, P. S., Polegato, B. F., Minicucci, M. F., & Paiva, S. A. (2016). Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment. Arquivos Brasileiros de Cardiologia, 106, 62\u201369.","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"10108_CR69","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1161\/CIRCULATIONAHA.110.943431","volume":"122","author":"K Toischer","year":"2010","unstructured":"Toischer, K., Rokita, A. G., Unsold, B., & Zhu, W. (2010). Differential cardiac remodeling in preload versus afterload. Circulation, 122, 993\u20131003.","journal-title":"Circulation"},{"key":"10108_CR70","doi-asserted-by":"crossref","unstructured":"Yu, R., Li, Q., Feng, Z., & Cai, L. (2019). m6A reader YTHDF2 regulates LPS-induced inflammatory response. International Journal of Molecular Sciences, 20.","DOI":"10.3390\/ijms20061323"},{"key":"10108_CR71","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1111\/jcmm.13491","volume":"22","author":"Z Feng","year":"2018","unstructured":"Feng, Z., Li, Q., Meng, R., & Yi, B. (2018). METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells. Journal of Cellular and Molecular Medicine, 22, 2558\u20132568.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10108_CR72","doi-asserted-by":"crossref","unstructured":"Berulava T, Buchholz Es, V. Elerdashvili, Pena T. (2020). Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. European Journal of Heart Failure, 22(1), 54-66.","DOI":"10.1002\/ejhf.1672"},{"key":"10108_CR73","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s12013-015-0551-6","volume":"72","author":"R Sun","year":"2015","unstructured":"Sun, R., Liu, M., Lu, L., & Zheng, Y. (2015). Congenital heart disease: causes, diagnosis, symptoms, and treatments. Cell Biochemistry and Biophysics, 72, 857\u2013860.","journal-title":"Cell Biochemistry and Biophysics"},{"key":"10108_CR74","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1136\/heartjnl-2012-302543","volume":"98","author":"B Khoshnood","year":"2012","unstructured":"Khoshnood, B., Lelong, N., Houyel, L., & Thieulin, A. C. (2012). Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a population-based study. Heart, 98, 1667\u20131673.","journal-title":"Heart"},{"key":"10108_CR75","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1055\/s-0038-1632367","volume":"35","author":"N Lorzadeh","year":"2018","unstructured":"Lorzadeh, N., & Kazemirad, N. (2018). Embryonic stem cells and infertility. American Journal of Perinatology, 35, 925\u2013930.","journal-title":"American Journal of Perinatology"},{"key":"10108_CR76","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.hlc.2010.06.661","volume":"20","author":"SL Stubbs","year":"2011","unstructured":"Stubbs, S. L., Crook, J. M., Morrison, W. A., & Newcomb, A. E. (2011). Toward clinical application of stem cells for cardiac regeneration. Heart, Lung & Circulation, 20, 173\u2013179.","journal-title":"Heart, Lung & Circulation"},{"key":"10108_CR77","doi-asserted-by":"crossref","unstructured":"Fuegemann, C. J., Samraj, A. K., Walsh, & Fleischmann, B. K. (2010). Differentiation of mouse embryonic stem cells into cardiomyocytes via the hanging-drop and mass culture methods. Current Protocols in Stem Cell Biology, 1.","DOI":"10.1002\/9780470151808.sc01f11s15"},{"key":"10108_CR78","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.healun.2009.10.006","volume":"29","author":"S Rupp","year":"2010","unstructured":"Rupp, S., Zeiher, A. M., Dimmeler, S., & Tonn, T. (2010). A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells. The Journal of Heart and Lung Transplantation, 29, 574\u2013577.","journal-title":"The Journal of Heart and Lung Transplantation"},{"issue":"2","key":"10108_CR79","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.cell.2017.03.031","volume":"169","author":"B Slobodin","year":"2017","unstructured":"Slobodin, B., Han, R., Calderone, V., Vrielink, J. A. F. O., Loayza-Puch, F., Elkon, R., et al. (2017). Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation. Cell, 169(2), 326\u2013337.","journal-title":"Cell"},{"key":"10108_CR80","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.stem.2014.09.019","volume":"15","author":"PJ Batista","year":"2014","unstructured":"Batista, P. J., Molinie, B., Wang, J., & Qu, K. (2014). m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell, 15, 707\u2013719.","journal-title":"Cell Stem Cell"},{"key":"10108_CR81","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.stemcr.2016.10.009","volume":"8","author":"S Kadota","year":"2017","unstructured":"Kadota, S., Pabon, L., Reinecke, H., & Murry, C. E. (2017). In vivo maturation of human induced pluripotent stem cell-derived cardiomyocytes in neonatal and adult rat hearts. Stem Cell Reports, 8, 278\u2013289.","journal-title":"Stem Cell Reports"},{"key":"10108_CR82","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.celrep.2016.12.040","volume":"18","author":"GS Cho","year":"2017","unstructured":"Cho, G. S., Lee, D. I., Tampakakis, E., & Murphy, S. (2017). Neonatal transplantation confers maturation of PSC-derived cardiomyocytes conducive to modeling cardiomyopathy. Cell Reports, 18, 571\u2013582.","journal-title":"Cell Reports"},{"key":"10108_CR83","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1056\/NEJMoa1502821","volume":"373","author":"AC Skinner","year":"2015","unstructured":"Skinner, A. C., Perrin, E. M., Moss, L. A., & Skelton, J. A. (2015). Cardiometabolic risks and severity of obesity in children and young adults. The New England Journal of Medicine, 373, 1307\u20131317.","journal-title":"The New England Journal of Medicine"},{"key":"10108_CR84","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.pcad.2016.01.008","volume":"58","author":"CJ Lavie","year":"2016","unstructured":"Lavie, C. J., De Schutter, A., Parto, P., & Jahangir, E. (2016). Obesity and prevalence of cardiovascular diseases and prognosis-the obesity paradox updated. Progress in Cardiovascular Diseases, 58, 537\u2013547.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10108_CR85","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.pcad.2015.12.003","volume":"58","author":"CJ Lavie","year":"2016","unstructured":"Lavie, C. J., Sharma, A., Alpert, M. A., & De Schutter, A. (2016). Update on obesity and obesity paradox in heart failure. Progress in Cardiovascular Diseases, 58, 393\u2013400.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10108_CR86","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pcad.2014.05.003","volume":"57","author":"CJ Lavie","year":"2014","unstructured":"Lavie, C. J., Patel, D. A., Milani, R. V., & Ventura, H. O. (2014). Impact of echocardiographic left ventricular geometry on clinical prognosis. Progress in Cardiovascular Diseases, 57, 3\u20139.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10108_CR87","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.pcad.2013.10.016","volume":"56","author":"M Bastien","year":"2014","unstructured":"Bastien, M., Poirier, P., Lemieux, I., & Despres, J. P. (2014). Overview of epidemiology and contribution of obesity to cardiovascular disease. Progress in Cardiovascular Diseases, 56, 369\u2013381.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10108_CR88","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","volume":"384","author":"M Ng","year":"2014","unstructured":"Ng, M., Fleming, T., Robinson, M., & Thomson, B. (2014). Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384, 766\u2013781.","journal-title":"Lancet"},{"key":"10108_CR89","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1016\/j.jacc.2006.03.072","volume":"48","author":"SR Heckbert","year":"2006","unstructured":"Heckbert, S. R., Post, W., Pearson, G. D., & Arnett, D. K. (2006). Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. Journal of the American College of Cardiology, 48, 2285\u20132292.","journal-title":"Journal of the American College of Cardiology"},{"key":"10108_CR90","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/ajh\/hpv156","volume":"29","author":"AB Santos","year":"2016","unstructured":"Santos, A. B., Gupta, D. K., Bello, N. A., & Gori, M. (2016). Prehypertension is associated with abnormalities of cardiac structure and function in the atherosclerosis risk in communities study. American Journal of Hypertension, 29, 568\u2013574.","journal-title":"American Journal of Hypertension"},{"key":"10108_CR91","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1055\/s-0028-1087176","volume":"117","author":"A Haupt","year":"2009","unstructured":"Haupt, A., Thamer, C., Staiger, H., & Tschritter, O. (2009). Variation in the FTO gene influences food intake but not energy expenditure. Experimental and Clinical Endocrinology & Diabetes, 117, 194\u2013197.","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"10108_CR92","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1056\/NEJMoa0803839","volume":"359","author":"JE Cecil","year":"2008","unstructured":"Cecil, J. E., Tavendale, R., Watt, P., & Hetherington, M. M. (2008). An obesity-associated FTO gene variant and increased energy intake in children. The New England Journal of Medicine, 359, 2558\u20132566.","journal-title":"The New England Journal of Medicine"},{"key":"10108_CR93","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature13138","volume":"507","author":"S Smemo","year":"2014","unstructured":"Smemo, S., Tena, J. J., Kim, K. H., & Gamazon, E. R. (2014). Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature, 507, 371\u2013375.","journal-title":"Nature"},{"key":"10108_CR94","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1056\/NEJMoa1502214","volume":"373","author":"M Claussnitzer","year":"2015","unstructured":"Claussnitzer, M., Dankel, S. N., Kim, K. H., & Quon, G. (2015). FTO obesity variant circuitry and adipocyte browning in humans. The New England Journal of Medicine, 373, 895\u2013907.","journal-title":"The New England Journal of Medicine"},{"key":"10108_CR95","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.cmet.2014.04.009","volume":"19","author":"G Stratigopoulos","year":"2014","unstructured":"Stratigopoulos, G., Martin Carli, J. F., O\u2019Day, D. R., & Wang, L. (2014). Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metabolism, 19, 767\u2013779.","journal-title":"Cell Metabolism"},{"key":"10108_CR96","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1172\/JCI44403","volume":"123","author":"E Karra","year":"2013","unstructured":"Karra, E., O\u2019Daly, O. G., Choudhury, A. I., & Yousseif, A. (2013). A link between FTO, ghrelin, and impaired brain food-cue responsivity. The Journal of Clinical Investigation, 123, 3539\u20133551.","journal-title":"The Journal of Clinical Investigation"},{"key":"10108_CR97","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s12967-015-0746-z","volume":"13","author":"BC Melnik","year":"2015","unstructured":"Melnik, B. C. (2015). Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. Journal of Translational Medicine, 13, 385.","journal-title":"Journal of Translational Medicine"},{"key":"10108_CR98","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature07848","volume":"458","author":"J Fischer","year":"2009","unstructured":"Fischer, J., Koch, L., Emmerling, C., & Vierkotten, J. (2009). Inactivation of the Fto gene protects from obesity. Nature, 458, 894\u2013898.","journal-title":"Nature"},{"key":"10108_CR99","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/ng.713","volume":"42","author":"C Church","year":"2010","unstructured":"Church, C., Moir, L., McMurray, F., & Girard, C. (2010). Overexpression of Fto leads to increased food intake and results in obesity. Nature Genetics, 42, 1086\u20131092.","journal-title":"Nature Genetics"},{"key":"10108_CR100","doi-asserted-by":"crossref","unstructured":"Liu, C., Mou, S., & Pan, C. (2013). The FTO gene rs9939609 polymorphism predicts risk of cardiovascular disease: a systematic review and meta-analysis. PLoS One, 8.","DOI":"10.1371\/journal.pone.0071901"},{"key":"10108_CR101","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s12253-015-9913-z","volume":"21","author":"JV Fernandes","year":"2015","unstructured":"Fernandes, J. V., Cobucci, R. N., Jatoba, C. A., & Fernandes, T. A. (2015). The role of the mediators of inflammation in cancer development. Pathology Oncology Research, 21, 527\u2013534.","journal-title":"Pathology Oncology Research"},{"key":"10108_CR102","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12199-018-0740-1","volume":"23","author":"M Murata","year":"2018","unstructured":"Murata, M. (2018). Inflammation and cancer. Environmental Health and Preventive Medicine, 23, 50.","journal-title":"Environmental Health and Preventive Medicine"},{"key":"10108_CR103","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ijbiomac.2018.05.039","volume":"116","author":"SB Park","year":"2018","unstructured":"Park, S. B., Park, G. H., Um, Y., & Kim, H. N. (2018). Wood-cultivated ginseng exerts anti-inflammatory effect in LPS-stimulated RAW264.7 cells. International Journal of Biological Macromolecules, 116, 327\u2013334.","journal-title":"International Journal of Biological Macromolecules"},{"key":"10108_CR104","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jep.2017.08.034","volume":"210","author":"YH Zou","year":"2018","unstructured":"Zou, Y. H., Zhao, L., Xu, Y. K., & Bao, J. M. (2018). Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: regulates pro-inflammatory mediators through inhibition of NF-kappaB and Erk1\/2 signaling pathways in LPS-induced Raw264.7 cells. Journal of Ethnopharmacology, 210, 95\u2013106.","journal-title":"Journal of Ethnopharmacology"},{"key":"10108_CR105","doi-asserted-by":"publisher","first-page":"6399","DOI":"10.3892\/mmr.2015.4243","volume":"12","author":"J Zou","year":"2015","unstructured":"Zou, J., Guo, P., Lv, N., & Huang, D. (2015). Lipopolysaccharide-induced tumor necrosis factor-alpha factor enhances inflammation and is associated with cancer (Review). Molecular Medicine Reports, 12, 6399\u20136404.","journal-title":"Molecular Medicine Reports"},{"key":"10108_CR106","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1083\/jcb.201412052","volume":"209","author":"I Tabas","year":"2015","unstructured":"Tabas, I., Garcia-Cardena, G., & Owens, G. K. (2015). Recent insights into the cellular biology of atherosclerosis. The Journal of Cell Biology, 209, 13\u201322.","journal-title":"The Journal of Cell Biology"},{"key":"10108_CR107","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.yexmp.2018.01.008","volume":"104","author":"DA Chistiakov","year":"2018","unstructured":"Chistiakov, D. A., Melnichenko, A. A., Grechko, A. V., & Myasoedova, V. A. (2018). Potential of anti-inflammatory agents for treatment of atherosclerosis. Experimental and Molecular Pathology, 104, 114\u2013124.","journal-title":"Experimental and Molecular Pathology"},{"key":"10108_CR108","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.mehy.2007.05.030","volume":"70","author":"Y Liu","year":"2008","unstructured":"Liu, Y., Yu, H., Zhang, Y., & Zhao, Y. (2008). TLRs are important inflammatory factors in atherosclerosis and may be a therapeutic target. Medical Hypotheses, 70, 314\u2013316.","journal-title":"Medical Hypotheses"},{"key":"10108_CR109","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.jacc.2010.06.015","volume":"56","author":"RS Rosenson","year":"2010","unstructured":"Rosenson, R. S., Hislop, C., Elliott, M., & Stasiv, Y. (2010). Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients. Journal of the American College of Cardiology, 56, 1079\u20131088.","journal-title":"Journal of the American College of Cardiology"},{"key":"10108_CR110","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jconrel.2017.07.013","volume":"262","author":"A Alaarg","year":"2017","unstructured":"Alaarg, A., Senders, M. L., Varela-Moreira, A., & Perez-Medina, C. (2017). A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis. Journal of Controlled Release, 262, 47\u201357.","journal-title":"Journal of Controlled Release"},{"key":"10108_CR111","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.vph.2016.04.006","volume":"82","author":"A Alaarg","year":"2016","unstructured":"Alaarg, A., Zheng, K. H., van der Valk, F. M., & da Silva, A. E. (2016). Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques. Vascular Pharmacology, 82, 51\u201359.","journal-title":"Vascular Pharmacology"},{"key":"10108_CR112","first-page":"7418","volume":"44","author":"C Tiedje","year":"2016","unstructured":"Tiedje, C., Diaz-Munoz, M. D., Trulley, P., Ahlfors, H., Laass, K., Blackshear, P. J., et al. (2016). The RNAbinding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Research, 44, 7418\u20137440.","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10108_CR113","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.jmb.2017.12.018","volume":"430","author":"D Bulbrook","year":"2018","unstructured":"Bulbrook, D., Brazier, H., Mahajan, P., Kliszczak, M., Fedorov, O., Marchese, F. P., et al. (2018). Tryptophan-mediated interactions between tristetraprolin and the CNOT9 subunit are required for CCR4-NOT deadenylase complex recruitment. Journal of Molecular Biology, 430(5), 722\u2013736.","journal-title":"Journal of Molecular Biology"},{"key":"10108_CR114","doi-asserted-by":"crossref","unstructured":"Hafidi, M. E., & Buelna-Chontal, M. (2019). Adipogenesis: a necessary but harmful strategy. International Journal of Molecular Sciences, 20.","DOI":"10.3390\/ijms20153657"},{"key":"10108_CR115","doi-asserted-by":"publisher","first-page":"247","DOI":"10.4093\/dmj.2018.0221","volume":"43","author":"CY Woo","year":"2019","unstructured":"Woo, C. Y., Jang, J. E., Lee, S. E., & Koh, E. H. (2019). Mitochondrial dysfunction in adipocytes as a primary cause of adipose tissue inflammation. Diabetes and Metabolism Journal, 43, 247\u2013256.","journal-title":"Diabetes and Metabolism Journal"},{"key":"10108_CR116","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nrm2066","volume":"7","author":"ED Rosen","year":"2006","unstructured":"Rosen, E. D., & MacDougald, O. A. (2006). Adipocyte differentiation from the inside out. Nature Reviews. Molecular Cell Biology, 7, 885\u2013896.","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10108_CR117","doi-asserted-by":"crossref","unstructured":"Kobayashi, M., Ohsugi, M., Sasako, T., & Awazawa, M. (2018). The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis. Molecular and Cellular Biology, 38.","DOI":"10.1128\/MCB.00116-18"},{"key":"10108_CR118","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"X Zhao","year":"2014","unstructured":"Zhao, X., Yang, Y., Sun, B. F., & Shi, Y. (2014). FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Research, 24, 1403\u20131419.","journal-title":"Cell Research"},{"key":"10108_CR119","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","volume":"1863","author":"R Wu","year":"2018","unstructured":"Wu, R., Liu, Y., Yao, Y., & Zhao, Y. (2018). FTO regulates adipogenesis by controlling cell cycle progression via m(6)A-YTHDF2 dependent mechanism. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863, 1323\u20131330.","journal-title":"Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids"},{"key":"10108_CR120","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1038\/s41366-018-0027-z","volume":"42","author":"X Wang","year":"2018","unstructured":"Wang, X., Sun, B., Jiang, Q., & Wu, R. (2018). mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes. International Journal of Obesity, 42, 1912\u20131924.","journal-title":"International Journal of Obesity"},{"key":"10108_CR121","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1096\/fj.201801393RRR","volume":"33","author":"Q Jiang","year":"2019","unstructured":"Jiang, Q., Sun, B., Liu, Q., & Cai, M. (2019). MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m(6)A-YTHDF1-dependent mechanism. The FASEB Journal, 33, 2971\u20132981.","journal-title":"The FASEB Journal"},{"key":"10108_CR122","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1038\/s41366-018-0082-5","volume":"42","author":"R Wu","year":"2018","unstructured":"Wu, R., Yao, Y., Jiang, Q., & Cai, M. (2018). Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m(6)A-YTHDF2-dependent manner. International Journal of Obesity, 42, 1378.","journal-title":"International Journal of Obesity"},{"key":"10108_CR123","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1093\/nar\/gkz312","volume":"47","author":"T Song","year":"2019","unstructured":"Song, T., Yang, Y., Wei, H., & Xie, X. (2019). Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Research, 47, 6130\u20136144.","journal-title":"Nucleic Acids Research"},{"key":"10108_CR124","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1080\/15476286.2019.1658508","volume":"16","author":"Q Liu","year":"2019","unstructured":"Liu, Q., Zhao, Y., Wu, R., & Jiang, Q. (2019). ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner. RNA Biology, 16, 1785\u20131793.","journal-title":"RNA Biology"},{"key":"10108_CR125","first-page":"336","volume":"50","author":"L Budiyani","year":"2018","unstructured":"Budiyani, L., Purnamasari, D., Simadibrata, M., & Abdullah, M. (2018). Insulin resistance in gastroesophageal reflux disease. Acta Medica Indonesiana, 50, 336\u2013342.","journal-title":"Acta Medica Indonesiana"},{"key":"10108_CR126","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/1479164115610057","volume":"131","author":"MR Salazar","year":"2016","unstructured":"Salazar, M. R., Carbajal, H. A., Espeche, W. G., & Aizpurua, M. (2016). Insulin resistance: the linchpin between prediabetes and cardiovascular disease. Diabetes & Vascular Disease Research, 131, 157\u2013163.","journal-title":"Diabetes & Vascular Disease Research"},{"key":"10108_CR127","doi-asserted-by":"crossref","unstructured":"Gast, K. B., Tjeerdema, N., Stijnen, T., & Smit, J. W. (2012). Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One, 7.","DOI":"10.1371\/journal.pone.0052036"},{"key":"10108_CR128","first-page":"480","volume":"59","author":"S Sandeep","year":"2011","unstructured":"Sandeep, S., Gokulakrishnan, K., Deepa, M., & Mohan, V. (2011). Insulin resistance is associated with increased cardiovascular risk in Asian Indians with normal glucose tolerance--the Chennai Urban Rural Epidemiology Study (CURES-66). The Journal of the Association of Physicians of India, 59, 480\u2013484.","journal-title":"The Journal of the Association of Physicians of India"},{"key":"10108_CR129","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2459\/JCM.0b013e328333645a","volume":"11","author":"KJ Reddy","year":"2010","unstructured":"Reddy, K. J., Singh, M., Bangit, J. R., & Batsell, R. R. (2010). The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: an updated review. Journal of Cardiovascular Medicine (Hagerstown, Md.), 11, 633\u2013647.","journal-title":"Journal of Cardiovascular Medicine (Hagerstown, Md.)"},{"key":"10108_CR130","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.hlc.2008.11.003","volume":"18","author":"RH Ritchie","year":"2009","unstructured":"Ritchie, R. H. (2009). Evidence for a causal role of oxidative stress in the myocardial complications of insulin resistance. Heart, Lung & Circulation, 18, 11\u201318.","journal-title":"Heart, Lung & Circulation"},{"key":"10108_CR131","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.jacc.2008.08.081","volume":"53","author":"MA AlZadjali","year":"2009","unstructured":"AlZadjali, M. A., Godfrey, V., Khan, F., & Choy, A. (2009). Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure. Journal of the American College of Cardiology, 53, 747\u2013753.","journal-title":"Journal of the American College of Cardiology"},{"key":"10108_CR132","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2019.08.018","volume":"518","author":"W Xie","year":"2019","unstructured":"Xie, W., Ma, L. L., Xu, Y. Q., & Wang, B. H. (2019). METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism. Biochemical and Biophysical Research Communications, 518, 120\u2013126.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10108_CR133","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s13104-018-3392-8","volume":"11","author":"K Iskandar","year":"2018","unstructured":"Iskandar, K., Patria, S. Y., Huriyati, E., & Luglio, H. F. (2018). Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents. BMC Research Notes, 11, 300.","journal-title":"BMC Research Notes"},{"key":"10108_CR134","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12944-019-1085-5","volume":"18","author":"A Khoshi","year":"2019","unstructured":"Khoshi, A., Bajestani, M. K., Shakeri, H., & Goodarzi, G. (2019). Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes. Lipids in Health and Disease, 18, 142.","journal-title":"Lipids in Health and Disease"},{"issue":"12","key":"10108_CR135","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1097\/HJH.0000000000002191","volume":"37","author":"M Han","year":"2019","unstructured":"Han, M., Li, Q., Liu, L., Zhang, D., Ren, Y., Zhao, Y., et al. (2019). Prehypertension and risk of cardiovascular diseases: a meta-analysis of 47 cohort studies. Journal of Hypertension, 37(12), 2325\u20132332.","journal-title":"Journal of Hypertension"},{"issue":"10","key":"10108_CR136","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/s41440-019-0277-8","volume":"42","author":"XB Mo","year":"2019","unstructured":"Mo, X. B., Lei, S. F., Zhang, Y. H., & Zhang, H. (2019). Examination of the associations between m6A-associated single-nucleotide polymorphisms and blood pressure. Hypertension Research, 42(10), 1582\u20131589.","journal-title":"Hypertension Research"},{"key":"10108_CR137","doi-asserted-by":"publisher","first-page":"D139","DOI":"10.1093\/nar\/gkx895","volume":"46","author":"Y Zheng","year":"2018","unstructured":"Zheng, Y., Nie, P., Peng, D., He, Z., Liu, M., Xie, Y., et al. (2018). m6AVar: a database of functional variants involved in m6A modification. Nucleic Acids Research, 46, D139\u2013D145.","journal-title":"Nucleic Acids Research"},{"issue":"12","key":"10108_CR138","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.2217\/epi-2019-0148","volume":"11","author":"Q Wu","year":"2019","unstructured":"Wu, Q., Yuan, X., Han, R., Zhang, H., & Xiu, R. (2019). Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes. Epigenomics, 11(12), 1359\u20131370.","journal-title":"Epigenomics"},{"issue":"9","key":"10108_CR139","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.2337\/dci15-0012","volume":"38","author":"CS Fox","year":"2015","unstructured":"Fox, C. S., Golden, S. H., Anderson, C., Bray, G. A., Burke, L. E., de Boer, I. H., et al. (2015). Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care, 38(9), 1777\u20131803.","journal-title":"Diabetes Care"},{"issue":"8","key":"10108_CR140","doi-asserted-by":"publisher","first-page":"841","DOI":"10.4161\/epi.21238","volume":"7","author":"ER Gilbert","year":"2012","unstructured":"Gilbert, E. R., & Liu, D. (2012). Epigenetics: the missing link to understanding \u03b2-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics, 7(8), 841\u2013852.","journal-title":"Epigenetics"},{"issue":"1","key":"10108_CR141","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1210\/jc.2014-1893","volume":"100","author":"F Shen","year":"2015","unstructured":"Shen, F., Huang, W., Huang, J. T., Xiong, J., Yang, Y., Wu, K., et al. (2015). Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5. The Journal of Clinical Endocrinology and Metabolism, 100(1), 148\u2013154.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"10108_CR142","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1210\/jc.2018-00619","volume":"104","author":"Y Yang","year":"2019","unstructured":"Yang, Y., Shen, F., Huang, W., Qin, S., Huang, J. T., Sergi, C., et al. (2019). Glucose is involved in the dynamic regulation of m6A in patients with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism, 104(3), 665\u2013673.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"8","key":"10108_CR143","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/s42255-019-0089-9","volume":"1","author":"DF De Jesus","year":"2019","unstructured":"De Jesus, D. F., Zhang, Z., Kahraman, S., Brown, N. K., Chen, M., Hu, J., et al. (2019). m6A mRNA methylation regulates human \u03b2-cell biology in physiological states and in type 2 diabetes. Nature Metabolism, 1(8), 765\u2013774.","journal-title":"Nature Metabolism"},{"key":"10108_CR144","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molcel.2018.06.015","volume":"71","author":"CL Xiao","year":"2018","unstructured":"Xiao, C. L., Zhu, S., He, M., & Chen, D. (2018). N(6)-methyladenine DNA modification in the human genome. Molecular Cell, 71, 306\u2013318.","journal-title":"Molecular Cell"},{"key":"10108_CR145","doi-asserted-by":"publisher","first-page":"11659","DOI":"10.1093\/nar\/gky1104","volume":"46","author":"CWQ Koh","year":"2018","unstructured":"Koh, C. W. Q., Goh, Y. T., Toh, J. D. W., & Neo, S. P. (2018). Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome. Nucleic Acids Research, 46, 11659\u201311670.","journal-title":"Nucleic Acids Research"},{"key":"10108_CR146","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","volume":"123","author":"W Zhang","year":"2018","unstructured":"Zhang, W., Song, M., Qu, J., & Liu, G. H. (2018). Epigenetic modifications in cardiovascular aging and diseases. Circulation Research, 123, 773\u2013786.","journal-title":"Circulation Research"},{"key":"10108_CR147","doi-asserted-by":"publisher","first-page":"7585","DOI":"10.1038\/ncomms8585","volume":"6","author":"AY Kim","year":"2015","unstructured":"Kim, A. Y., Park, Y. J., Pan, X., & Shin, K. C. (2015). Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nature Communications, 6, 7585.","journal-title":"Nature Communications"},{"key":"10108_CR148","doi-asserted-by":"publisher","first-page":"542","DOI":"10.2337\/db11-1048","volume":"61","author":"J Zhao","year":"2012","unstructured":"Zhao, J., Goldberg, J., Bremner, J. D., & Vaccarino, V. (2012). Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes, 61, 542\u2013546.","journal-title":"Diabetes"},{"key":"10108_CR149","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1365-2796.2007.01777.x","volume":"261","author":"P Stenvinkel","year":"2007","unstructured":"Stenvinkel, P., Karimi, M., Johansson, S., & Axelsson, J. (2007). Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease? Journal of Internal Medicine, 261, 488\u2013499.","journal-title":"Journal of Internal Medicine"},{"key":"10108_CR150","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1164\/rccm.200901-0135OC","volume":"180","author":"CV Breton","year":"2009","unstructured":"Breton, C. V., Byun, H. M., Wenten, M., & Pan, F. (2009). Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. American Journal of Respiratory and Critical Care Medicine, 180, 462\u2013467.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10108_CR151","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/CIRCULATIONAHA.118.039357","volume":"140","author":"G Agha","year":"2019","unstructured":"Agha, G., Mendelson, M. M., Ward-Caviness, C. K., & Joehanes, R. (2019). Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease. Circulation, 140, 645\u2013657.","journal-title":"Circulation"},{"key":"10108_CR152","doi-asserted-by":"publisher","first-page":"6276","DOI":"10.18632\/aging.103023","volume":"12","author":"Y Guo","year":"2020","unstructured":"Guo, Y., Pei, Y., & Li, C. W. (2020). DNA N(6)-methyladenine modification in hypertension. Aging (Albany NY), 12, 6276\u20136291.","journal-title":"Aging (Albany NY)"},{"key":"10108_CR153","doi-asserted-by":"crossref","unstructured":"Yan, X. C., Cao, J., Liang, L., & Wang, L. (2016). miR-342-5p is a notch downstream molecule and regulates multiple angiogenic pathways including notch, vascular endothelial growth factor and transforming growth factor beta signaling. Journal of the American Heart Association, 5.","DOI":"10.1161\/JAHA.115.003042"},{"key":"10108_CR154","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1016\/j.ajpath.2015.03.019","volume":"185","author":"RB Good","year":"2015","unstructured":"Good, R. B., Gilbane, A. J., Trinder, S. L., & Denton, C. P. (2015). Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension. The American Journal of Pathology, 185, 1850\u20131858.","journal-title":"The American Journal of Pathology"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10108-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-021-10108-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10108-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:14:34Z","timestamp":1650240874000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-021-10108-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":154,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10108"],"URL":"https:\/\/doi.org\/10.1007\/s12265-021-10108-w","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]},"assertion":[{"value":"8 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}