{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:44:07Z","timestamp":1740149047413,"version":"3.37.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Flagship project NANOMAX-ENCODER of the Italian Ministry of Education, University and Research","award":["00000"],"award-info":[{"award-number":["00000"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s12265-021-10165-1","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T21:02:57Z","timestamp":1629320577000},"page":"391-407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy"],"prefix":"10.1007","volume":"15","author":[{"given":"Claudia","family":"Kusmic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Vizzoca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Taranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Tedeschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Gherardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gualtiero","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambra","family":"Giannetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Tombelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Settimio","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Domenici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giovanna","family":"Trivella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-0369","authenticated-orcid":false,"given":"Caterina","family":"Cinti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"10165_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1161\/01.res.69.1.107","volume":"69","author":"CG Brilla","year":"1991","unstructured":"Brilla, C. G., Janicki, J. S., & Weber, K. T. (1991). Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. Circulation Research, 69, 107\u2013115. https:\/\/doi.org\/10.1161\/01.res.69.1.107","journal-title":"Circulation Research"},{"key":"10165_CR2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMoa1002659","volume":"363","author":"CY Ho","year":"2010","unstructured":"Ho, C. Y., L\u00f3pez, B., Coelho-Filho, O. R., Lakdawala, N. K., Cirino, A. L., Jarolim, P., Kwong, R., Gonz\u00e1lez, A., Colan, S. D., Seidman, J. G., D\u00edez, J., & Seidman, C. E. (2010). Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy. New England Journal of Medicine, 363, 552\u2013563. https:\/\/doi.org\/10.1056\/NEJMoa1002659","journal-title":"New England Journal of Medicine"},{"key":"10165_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev.physiol.59.1.551","volume":"59","author":"J Sadoshima","year":"1997","unstructured":"Sadoshima, J., & Izumo, S. (1997). The cellular and molecular response of cardiac myocytes to mechanical stress. Annual Review of Physiology, 59, 551\u2013571. https:\/\/doi.org\/10.1146\/annurev.physiol.59.1.551","journal-title":"Annual Review of Physiology"},{"key":"10165_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3747\/pdi.2013.00343","volume":"36","author":"HJ Kim","year":"2016","unstructured":"Kim, H. J., Park, M., Park, H. C., Jeong, J. C., Kim, D. K., Joo, K. W., Hwang, Y.-H., Yang, J., Ahn, C., & Oh, K.-H. (2016). Baseline Fgf23 is associated with cardiovascular outcome in incident Pd patients. Peritoneal Dialysis International, 36, 26\u201332. https:\/\/doi.org\/10.3747\/pdi.2013.00343","journal-title":"Peritoneal Dialysis International"},{"key":"10165_CR5","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.4236\/ijcm.2014.517141","volume":"05","author":"A Saito","year":"2014","unstructured":"Saito, A., Onuki, T., Echida, Y., Otsubo, S., & Nitta, K. (2014). Fibroblast growth factor 23 and left ventricular hypertrophy in hemodialysis patients. International Journal of Clinical Medicine, 05, 1102\u20131110. https:\/\/doi.org\/10.4236\/ijcm.2014.517141","journal-title":"International Journal of Clinical Medicine"},{"key":"10165_CR6","doi-asserted-by":"publisher","first-page":"E426","DOI":"10.1152\/ajpendo.00264.2014","volume":"307","author":"N Silswal","year":"2014","unstructured":"Silswal, N., Touchberry, C. D., Daniel, D. R., McCarthy, D. L., Zhang, S., Andresen, J., Stubbs, J. R., & Wacker, M. J. (2014). FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability. American Journal of Physiology Endocrinology and Metabolism, 307, E426\u2013E436. https:\/\/doi.org\/10.1152\/ajpendo.00264.2014","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"key":"10165_CR7","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1172\/JCI46122","volume":"121","author":"C Faul","year":"2011","unstructured":"Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Guti\u00e9rrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., Mundel, P., Morales, A., Scialla, J., Fischer, M., Soliman, E. Z., Chen, J., Go, A. S., Rosas, S. E., Nessel, L., \u2026 Wolf, M. (2011). FGF23 induces left ventricular hypertrophy. The Journal of Clinical Investigation, 121, 4393\u20134408. https:\/\/doi.org\/10.1172\/JCI46122","journal-title":"The Journal of Clinical Investigation"},{"key":"10165_CR8","doi-asserted-by":"publisher","first-page":"E863","DOI":"10.1152\/ajpendo.00596.2012","volume":"304","author":"CD Touchberry","year":"2013","unstructured":"Touchberry, C. D., Green, T. M., Tchikrizov, V., Mannix, J. E., Mao, T. F., Carney, B. W., Girgis, M., Vincent, R. J., Wetmore, L. A., Dawn, B., Bonewald, L. F., Stubbs, J. R., & Wacker, M. J. (2013). FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. American Journal of Physiology Endocrinology and Metabolism, 304, E863\u2013E873. https:\/\/doi.org\/10.1152\/ajpendo.00596.2012","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"key":"10165_CR9","doi-asserted-by":"publisher","first-page":"e00611","DOI":"10.1128\/MCB.00611-16","volume":"37","author":"R Datta","year":"2017","unstructured":"Datta, R., Bansal, T., Rana, S., Datta, K., Datta Chaudhuri, R., Chawla-Sarkar, M., & Sarkar, S. (2017). Myocyte-derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy. Molecular and Cellular Biology, 37, e00611-e616. https:\/\/doi.org\/10.1128\/MCB.00611-16","journal-title":"Molecular and Cellular Biology"},{"unstructured":"Bendall, J. K., Heymes, C., Ratajczak, P., & Samuel, J. L. (2002). Extracellular matrix and cardiac remodelling. Archives des Maladies du Coeur et des Vaisseaux, 95, 1226\u20131229.","key":"10165_CR10"},{"doi-asserted-by":"publisher","unstructured":"Carre\u00f1o, J. E., Apablaza, F., Ocaranza, M. P., & Jalil, J. E. (2006). Cardiac hypertrophy: Molecular and cellular events. Rev Espa\u00f1ola Cardiol English Ed, 59, 473\u2013486. https:\/\/doi.org\/10.1016\/S1885-5857(06)60796-2","key":"10165_CR11","DOI":"10.1016\/S1885-5857(06)60796-2"},{"key":"10165_CR12","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0022-2828(95)90000-4","volume":"27","author":"A Gerdes","year":"1995","unstructured":"Gerdes, A., & Capasso, J. (1995). Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure. Journal of Molecular and Cellular Cardiology, 27, 849\u2013856. https:\/\/doi.org\/10.1016\/0022-2828(95)90000-4","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10165_CR13","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1016\/j.ajpath.2012.08.045","volume":"181","author":"P-L Kuo","year":"2012","unstructured":"Kuo, P.-L., Lee, H., Bray, M.-A., Geisse, N. A., Huang, Y.-T., Adams, W. J., Sheehy, S. P., & Parker, K. K. (2012). Myocyte shape regulates lateral registry of sarcomeres and contractility. American Journal of Pathology, 181, 2030\u20132037. https:\/\/doi.org\/10.1016\/j.ajpath.2012.08.045","journal-title":"American Journal of Pathology"},{"key":"10165_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF02058278","volume":"6","author":"K Sawada","year":"1991","unstructured":"Sawada, K., & Kawamura, K. (1991). Architecture of myocardial cells in human cardiac ventricles with concentric and eccentric hypertrophy as demonstrated by quantitative scanning electron microscopy. Heart and Vessels, 6, 129\u2013142. https:\/\/doi.org\/10.1007\/BF02058278","journal-title":"Heart and Vessels"},{"key":"10165_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","volume":"128","author":"BC Bernardo","year":"2010","unstructured":"Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010). Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacology & Therapeutics, 128, 191\u2013227. https:\/\/doi.org\/10.1016\/j.pharmthera.2010.04.005","journal-title":"Pharmacology & Therapeutics"},{"key":"10165_CR16","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","volume":"109","author":"N Frey","year":"2004","unstructured":"Frey, N., Katus, H. A., Olson, E. N., & Hill, J. A. (2004). Hypertrophy of the heart: A new therapeutic target? Circulation, 109, 1580\u20131589. https:\/\/doi.org\/10.1161\/01.CIR.0000120390.68287.BB","journal-title":"Circulation"},{"key":"10165_CR17","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/s0008-6363(00)00003-1","volume":"46","author":"YY Li","year":"2000","unstructured":"Li, Y. Y., McTiernan, C. F., & Feldman, A. M. (2000). Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling. Cardiovascular Research, 46, 214\u2013224. https:\/\/doi.org\/10.1016\/s0008-6363(00)00003-1","journal-title":"Cardiovascular Research"},{"key":"10165_CR18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11010-013-1612-z","volume":"378","author":"A Parthasarathy","year":"2013","unstructured":"Parthasarathy, A., Gopi, V., Umadevi, S., Simna, A., Sheik, M. J. Y., Divya, H., & Vellaichamy, E. (2013). Suppression of atrial natriuretic peptide\/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts. Molecular and Cellular Biochemistry, 378, 217\u2013228. https:\/\/doi.org\/10.1007\/s11010-013-1612-z","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10165_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2014.09.014","volume":"118","author":"M Singh","year":"2014","unstructured":"Singh, M., Dalal, S., & Singh, K. (2014). Osteopontin: At the cross-roads of myocyte survival and myocardial function. Life Sciences, 118, 1\u20136. https:\/\/doi.org\/10.1016\/j.lfs.2014.09.014","journal-title":"Life Sciences"},{"key":"10165_CR20","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s10741-010-9158-6","volume":"15","author":"M Singh","year":"2010","unstructured":"Singh, M., Foster, C. R., Dalal, S., & Singh, K. (2010). Role of osteopontin in heart failure associated with aging. Heart Failure Reviews, 15, 487\u2013494. https:\/\/doi.org\/10.1007\/s10741-010-9158-6","journal-title":"Heart Failure Reviews"},{"key":"10165_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-016-2725-y","volume":"418","author":"S Dalal","year":"2016","unstructured":"Dalal, S., Zha, Q., Singh, M., & Singh, K. (2016). Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: Role of a pro-apoptotic protein BIK. Molecular and Cellular Biochemistry, 418, 1\u201311. https:\/\/doi.org\/10.1007\/s11010-016-2725-y","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10165_CR22","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/aps.2012.164","volume":"34","author":"Y Li","year":"2013","unstructured":"Li, Y., Li, X., Guo, S., Chu, S., Gao, P., Zhu, D., Niu, W., & Jia, N. (2013). Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice. Acta Pharmacologica Sinica, 34, 352\u2013359. https:\/\/doi.org\/10.1038\/aps.2012.164","journal-title":"Acta Pharmacologica Sinica"},{"key":"10165_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s1388-9842(01)00237-9","volume":"4","author":"P Stawowy","year":"2002","unstructured":"Stawowy, P., Blaschke, F., Pfautsch, P., Goetze, S., Lippek, F., Wollert-Wulf, B., Fleck, E., & Graf, K. (2002). Increased myocardial expression of osteopontin in patients with advanced heart failure. European Journal of Heart Failure, 4, 139\u2013146. https:\/\/doi.org\/10.1016\/s1388-9842(01)00237-9","journal-title":"European Journal of Heart Failure"},{"key":"10165_CR24","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/cvr\/cvx016","volume":"113","author":"J Li","year":"2017","unstructured":"Li, J., Yousefi, K., Ding, W., Singh, J., & Shehadeh, L. A. (2017). Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure. Cardiovascular Research, 113, 633\u2013643. https:\/\/doi.org\/10.1093\/cvr\/cvx016","journal-title":"Cardiovascular Research"},{"key":"10165_CR25","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.7150\/thno.20005","volume":"7","author":"T-J Tsang","year":"2017","unstructured":"Tsang, T.-J., Hsueh, Y.-C., Wei, E. I., Lundy, D. J., Cheng, B., Chen, Y.-T., Wang, S.-S., & Hsieh, P. C. H. (2017). Subcellular localization of survivin determines its function in cardiomyocytes. Theranostics, 7, 4577\u20134590. https:\/\/doi.org\/10.7150\/thno.20005","journal-title":"Theranostics"},{"key":"10165_CR26","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.26355\/eurrev_201708_13287","volume":"21","author":"L Bo","year":"2017","unstructured":"Bo, L., Zhu, X.-S., Zheng, Z., Hu, X.-P., & Chen, P.-Y. (2017). Research on the function and mechanism of survivin in heart failure mice model. European Review for Medical and Pharmacological Sciences, 21, 3699\u20133704. https:\/\/doi.org\/10.26355\/eurrev_201708_13287","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10165_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.yjmcc.2010.08.017","volume":"50","author":"R Si","year":"2011","unstructured":"Si, R., Tao, L., Zhang, H. F., Yu, Q. J., Zhang, R., Lv, A. L., Zhou, N., Cao, F., Guo, W. Y., Ren, J., Wang, H. C., & Gao, F. (2011). Survivin: A novel player in insulin cardioprotection against myocardial ischemia\/reperfusion injury. Journal of Molecular and Cellular Cardiology, 50, 16\u201324. https:\/\/doi.org\/10.1016\/j.yjmcc.2010.08.017","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10165_CR28","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1161\/CIRCULATIONAHA.107.734160","volume":"117","author":"B Levkau","year":"2008","unstructured":"Levkau, B., Sch\u00e4fers, M., Wohlschlaeger, J., von Wnuck, L. K., Keul, P., Hermann, S., Kawaguchi, N., Kirchhof, P., Fabritz, L., Stypmann, J., Stegger, L., Fl\u00f6gel, U., Schrader, J., Fischer, J. W., Hsieh, P., Ou, Y.-L., Mehrhof, F., Tiemann, K., Ghanem, A., \u2026 Baba, H. A. (2008). Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation, 117, 1583\u20131593. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.734160","journal-title":"Circulation"},{"key":"10165_CR29","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.healun.2010.06.015","volume":"29","author":"J Wohlschlaeger","year":"2010","unstructured":"Wohlschlaeger, J., Meier, B., Schmitz, K. J., Takeda, A., Takeda, N., Vahlhaus, C., Levkau, B., Stypmann, J., Schmid, C., Schmid, K. W., & Baba, H. A. (2010). Cardiomyocyte survivin protein expression is associated with cell size and DNA content in the failing human heart and is reversibly regulated after ventricular unloading. J Heart Lung Transplant, 29, 1286\u20131292. https:\/\/doi.org\/10.1016\/j.healun.2010.06.015","journal-title":"J Heart Lung Transplant"},{"key":"10165_CR30","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cardiores.2005.06.030","volume":"68","author":"J Wohlschlaeger","year":"2005","unstructured":"Wohlschlaeger, J., Schmitz, K. J., Schmid, C., Schmid, K. W., Keul, P., Takeda, A., Weis, S., Levkau, B., & Baba, H. A. (2005). Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes. Cardiovascular Research, 68, 376\u2013386. https:\/\/doi.org\/10.1016\/j.cardiores.2005.06.030","journal-title":"Cardiovascular Research"},{"key":"10165_CR31","doi-asserted-by":"publisher","first-page":"e17132","DOI":"10.1371\/journal.pone.0017132","volume":"6","author":"C Cinti","year":"2011","unstructured":"Cinti, C., Taranta, M., Naldi, I., & Grimaldi, S. (2011). Newly engineered magnetic erythrocytes for sustained and targeted delivery of anti-cancer therapeutic compounds. PLoS ONE, 6, e17132. https:\/\/doi.org\/10.1371\/journal.pone.0017132","journal-title":"PLoS ONE"},{"key":"10165_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jconrel.2018.04.052","volume":"280","author":"R Grifantini","year":"2018","unstructured":"Grifantini, R., Taranta, M., Gherardini, L., Naldi, I., Parri, M., Grandi, A., Giannetti, A., Tombelli, S., Lucarini, G., Ricotti, L., Campagnoli, S., De Camilli, E., Pelosi, G., Baldini, F., Menciassi, A., Viale, G., Pileri, P., & Cinti, C. (2018). Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer. Journal of Controlled Release, 280, 76\u201386. https:\/\/doi.org\/10.1016\/j.jconrel.2018.04.052","journal-title":"Journal of Controlled Release"},{"key":"10165_CR33","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2174\/187152912801823101","volume":"12","author":"C Lande","year":"2012","unstructured":"Lande, C., Cecchettini, A., Tedeschi, L., Taranta, M., Naldi, I., Citti, L., Trivella, M. G., Grimaldi, S., & Cinti, C. (2012). Innovative erythrocyte-based carriers for gene delivery in porcine vascular smooth muscle cells: Basis for local therapy to prevent restenosis. Cardiovascular & Hematological Disorders: Drug Targets, 12, 68\u201375. https:\/\/doi.org\/10.2174\/187152912801823101","journal-title":"Cardiovascular & Hematological Disorders: Drug Targets"},{"key":"10165_CR34","doi-asserted-by":"publisher","first-page":"45005","DOI":"10.1088\/2057-1976\/ab89f1","volume":"6","author":"G Lucarini","year":"2020","unstructured":"Lucarini, G., Sbaraglia, F., Vizzoca, A., Cinti, C., Ricotti, L., & Menciassi, A. (2020). Design of an innovative platform for the treatment of cerebral tumors by means of erythro-magneto-HA-virosomes. Biomed Phys Eng Express, 6, 45005. https:\/\/doi.org\/10.1088\/2057-1976\/ab89f1","journal-title":"Biomed Phys Eng Express"},{"key":"10165_CR35","doi-asserted-by":"publisher","first-page":"e98101","DOI":"10.1371\/journal.pone.0098101","volume":"9","author":"I Naldi","year":"2014","unstructured":"Naldi, I., Taranta, M., Gherardini, L., Pelosi, G., Viglione, F., Grimaldi, S., Pani, L., & Cinti, C. (2014). Novel epigenetic target therapy for prostate cancer: A preclinical study. PLoS ONE, 9, e98101. https:\/\/doi.org\/10.1371\/journal.pone.0098101","journal-title":"PLoS ONE"},{"key":"10165_CR36","doi-asserted-by":"publisher","first-page":"e114588","DOI":"10.1371\/journal.pone.0114588","volume":"9","author":"S Carpi","year":"2014","unstructured":"Carpi, S., Fogli, S., Giannetti, A., Adinolfi, B., Tombelli, S., Da Pozzo, E., Vanni, A., Martinotti, E., Martini, C., Breschi, M. C., Pellegrino, M., Nieri, P., & Baldini, F. (2014). Theranostic properties of a survivin-directed molecular beacon in human melanoma cells. PLoS ONE, 9, e114588. https:\/\/doi.org\/10.1371\/journal.pone.0114588","journal-title":"PLoS ONE"},{"key":"10165_CR37","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1093\/nar\/gnh063","volume":"32","author":"N Nitin","year":"2004","unstructured":"Nitin, N., Santangelo, P. J., Kim, G., Nie, S., & Bao, G. (2004). Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells. Nucleic Acids Research, 32, e58. https:\/\/doi.org\/10.1093\/nar\/gnh063","journal-title":"Nucleic Acids Research"},{"key":"10165_CR38","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nmeth.1455","volume":"7","author":"DJ Langford","year":"2010","unstructured":"Langford, D. J., Bailey, A. L., Chanda, M. L., Clarke, S. E., Drummond, T. E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., Lacroix-Fralish, M. L., Matsumiya, L., Sorge, R. E., Sotocinal, S. G., Tabaka, J. M., Wong, D., van den Maagdenberg, A. M. J. M., Ferrari, M. D., Craig, K. D., & Mogil, J. S. (2010). Coding of facial expressions of pain in the laboratory mouse. Nature Methods, 7, 447\u2013449. https:\/\/doi.org\/10.1038\/nmeth.1455","journal-title":"Nature Methods"},{"unstructured":"Cinti C, Lisi A, Grimaldi S (2010) Patent N. WO 2010\/070620","key":"10165_CR39"},{"key":"10165_CR40","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1172\/JCI113951","volume":"83","author":"CS Long","year":"1989","unstructured":"Long, C. S., Ordahl, C. P., & Simpson, P. C. (1989). Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. The Journal of Clinical Investigation, 83, 1078\u20131082. https:\/\/doi.org\/10.1172\/JCI113951","journal-title":"The Journal of Clinical Investigation"},{"key":"10165_CR41","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1016\/s0024-3205(98)00452-4","volume":"63","author":"S Adachi","year":"1998","unstructured":"Adachi, S., Ito, H., Tamamori, M., Tanaka, M., Marumo, F., & Hiroe, M. (1998). Skeletal and smooth muscle alpha-actin mRNA in endomyocardial biopsy samples of dilated cardiomyopathy patients. Life Sciences, 63, 1779\u20131791. https:\/\/doi.org\/10.1016\/s0024-3205(98)00452-4","journal-title":"Life Sciences"},{"key":"10165_CR42","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke, J., & Molkentin, J. D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature Reviews Molecular Cell Biology, 7, 589\u2013600. https:\/\/doi.org\/10.1038\/nrm1983","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10165_CR43","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1161\/01.res.74.4.740","volume":"74","author":"TE Hewett","year":"1994","unstructured":"Hewett, T. E., Grupp, I. L., Grupp, G., & Robbins, J. (1994). Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circulation Research, 74, 740\u2013746. https:\/\/doi.org\/10.1161\/01.res.74.4.740","journal-title":"Circulation Research"},{"key":"10165_CR44","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nrg1470","volume":"5","author":"C-C Liew","year":"2004","unstructured":"Liew, C.-C., & Dzau, V. J. (2004). Molecular genetics and genomics of heart failure. Nature Reviews Genetics, 5, 811\u2013825. https:\/\/doi.org\/10.1038\/nrg1470","journal-title":"Nature Reviews Genetics"},{"key":"10165_CR45","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.114.011079","volume":"131","author":"QD Zhao","year":"2015","unstructured":"Zhao, Q. D., Viswanadhapalli, S., Williams, P., Shi, Q., Tan, C., Yi, X., Bhandari, B., & Abboud, H. E. (2015). NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt\/mTOR and NF\u03baB signaling pathways. Circulation, 131, 643\u2013655. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.011079","journal-title":"Circulation"},{"key":"10165_CR46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00000441-199907000-00006","volume":"318","author":"PM Barger","year":"1999","unstructured":"Barger, P. M., & Kelly, D. P. (1999). Fatty acid utilization in the hypertrophied and failing heart: Molecular regulatory mechanisms. American Journal of the Medical Sciences, 318, 36\u201342. https:\/\/doi.org\/10.1097\/00000441-199907000-00006","journal-title":"American Journal of the Medical Sciences"},{"key":"10165_CR47","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev.pharmtox.47.120505.105230","volume":"47","author":"R Schulz","year":"2007","unstructured":"Schulz, R. (2007). Intracellular targets of matrix metalloproteinase-2 in cardiac disease: Rationale and therapeutic approaches. Annual Review of Pharmacology and Toxicology, 47, 211\u2013242. https:\/\/doi.org\/10.1146\/annurev.pharmtox.47.120505.105230","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"10165_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bios.2016.05.102","volume":"88","author":"B Adinolfi","year":"2017","unstructured":"Adinolfi, B., Pellegrino, M., Giannetti, A., Tombelli, S., Trono, C., Sotgiu, G., Varchi, G., Ballestri, M., Posati, T., Carpi, S., Nieri, P., & Baldini, F. (2017). Molecular beacon-decorated polymethylmethacrylate core-shell fluorescent nanoparticles for the detection of survivin mRNA in human cancer cells. Biosensors & Bioelectronics, 88, 15\u201324. https:\/\/doi.org\/10.1016\/j.bios.2016.05.102","journal-title":"Biosensors & Bioelectronics"},{"key":"10165_CR49","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1042\/CS20171269","volume":"132","author":"BC Bernardo","year":"2018","unstructured":"Bernardo, B. C., Weeks, K. L., Pongsukwechkul, T., Gao, X., Kiriazis, H., Cemerlang, N., Boey, E. J. H., Tham, Y. K., Johnson, C. J., Qian, H., Du, X.-J., Gregorevic, P., & McMullen, J. R. (2018). Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling. Clinical Science (London, England), 132, 381\u2013397. https:\/\/doi.org\/10.1042\/CS20171269","journal-title":"Clinical Science (London, England)"},{"key":"10165_CR50","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761","volume":"2","author":"RD Patten","year":"2009","unstructured":"Patten, R. D., & Hall-Porter, M. R. (2009). Small animal models of heart failure: Development of novel therapies, past and present. Circulation. Heart Failure, 2, 138\u2013144. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.108.839761","journal-title":"Circulation. Heart Failure"},{"key":"10165_CR51","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bone.2016.10.001","volume":"100","author":"C Faul","year":"2017","unstructured":"Faul, C. (2017). Cardiac actions of fibroblast growth factor 23. Bone, 100, 69\u201379. https:\/\/doi.org\/10.1016\/j.bone.2016.10.001","journal-title":"Bone"},{"key":"10165_CR52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1001\/jamacardio.2016.0008","volume":"1","author":"HK Hammond","year":"2016","unstructured":"Hammond, H. K., Penny, W. F., Traverse, J. H., Henry, T. D., Watkins, M. W., Yancy, C. W., Sweis, R. N., Adler, E. D., Patel, A. N., Murray, D. R., Ross, R. S., Bhargava, V., Maisel, A., Barnard, D. D., Lai, N. C., Dalton, N. D., Lee, M. L., Narayan, S. M., Blanchard, D. G., & Gao, M. H. (2016). Intracoronary gene transfer of adenylyl cyclase 6 in patients with heart failure: A randomized clinical trial. JAMA Cardiol, 1, 163\u2013171. https:\/\/doi.org\/10.1001\/jamacardio.2016.0008","journal-title":"JAMA Cardiol"},{"key":"10165_CR53","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1073\/pnas.97.2.793","volume":"97","author":"MI Miyamoto","year":"2000","unstructured":"Miyamoto, M. I., del Monte, F., Schmidt, U., DiSalvo, T. S., Kang, Z. B., Matsui, T., Guerrero, J. L., Gwathmey, J. K., Rosenzweig, A., & Hajjar, R. J. (2000). Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A, 97, 793\u2013798. https:\/\/doi.org\/10.1073\/pnas.97.2.793","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10165_CR54","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1002\/jgm.770","volume":"7","author":"HT Tevaearai","year":"2005","unstructured":"Tevaearai, H. T., Walton, G. B., Keys, J. R., Koch, W. J., & Eckhart, A. D. (2005). Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1). The Journal of Gene Medicine, 7, 1172\u20131177. https:\/\/doi.org\/10.1002\/jgm.770","journal-title":"The Journal of Gene Medicine"},{"key":"10165_CR55","doi-asserted-by":"publisher","first-page":"e012239","DOI":"10.1161\/JAHA.119.012239","volume":"8","author":"JM Kieserman","year":"2019","unstructured":"Kieserman, J. M., Myers, V. D., Dubey, P., Cheung, J. Y., & Feldman, A. M. (2019). Current landscape of heart failure gene therapy. Journal of the American Heart Association, 8, e012239. https:\/\/doi.org\/10.1161\/JAHA.119.012239","journal-title":"Journal of the American Heart Association"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10165-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-021-10165-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10165-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T15:06:25Z","timestamp":1649171185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-021-10165-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10165"],"URL":"https:\/\/doi.org\/10.1007\/s12265-021-10165-1","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"type":"print","value":"1937-5387"},{"type":"electronic","value":"1937-5395"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"24 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"No human studies were carried out by the authors for this article. All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}