{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:43:32Z","timestamp":1787787812940,"version":"build-2784847793"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770319"],"award-info":[{"award-number":["81770319"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12265-021-10170-4","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T12:03:01Z","timestamp":1631102581000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A New Minimally Invasive Method of Transverse Aortic Constriction in Mice"],"prefix":"10.1007","volume":"15","author":[{"given":"Huayang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangni","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-1182","authenticated-orcid":false,"given":"Zhongkai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"10170_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","volume":"97","author":"I Shimizu","year":"2016","unstructured":"Shimizu, I., & Minamino, T. (2016). Physiological and pathological cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 97, 245\u2013262. https:\/\/doi.org\/10.1016\/j.yjmcc.2016.06.001","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"6","key":"10170_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/jhh.2011.104","volume":"26","author":"C Cuspidi","year":"2012","unstructured":"Cuspidi, C., Sala, C., Negri, F., Mancia, G., & Morganti, A. (2012). Prevalence of left-ventricular hypertrophy in hypertension: An updated review of echocardiographic studies. Journal of Human Hypertension, 26(6), 343\u2013349. https:\/\/doi.org\/10.1038\/jhh.2011.104","journal-title":"Journal of Human Hypertension"},{"issue":"5","key":"10170_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cjca.2015.01.009","volume":"31","author":"DT Lackland","year":"2015","unstructured":"Lackland, D. T., & Weber, M. A. (2015). Global burden of cardiovascular disease and stroke: Hypertension at the core. Canadian Journal of Cardiology, 31(5), 569\u2013571. https:\/\/doi.org\/10.1016\/j.cjca.2015.01.009","journal-title":"Canadian Journal of Cardiology"},{"issue":"6","key":"10170_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1161\/circulationaha.115.018912","volume":"134","author":"KT Mills","year":"2016","unstructured":"Mills, K. T., Bundy, J. D., Kelly, T. N., Reed, J. E., Kearney, P. M., Reynolds, K., et al. (2016). Global disparities of hypertension prevalence and control: A systematic analysis of population-based studies from 90 countries. Circulation, 134(6), 441\u2013450. https:\/\/doi.org\/10.1161\/circulationaha.115.018912","journal-title":"Circulation"},{"issue":"4","key":"10170_CR5","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.hfc.2019.06.005","volume":"15","author":"MJ Sorrentino","year":"2019","unstructured":"Sorrentino, M. J. (2019). The evolution from hypertension to heart failure. Heart Failure Clinics, 15(4), 447\u2013453. https:\/\/doi.org\/10.1016\/j.hfc.2019.06.005","journal-title":"Heart Failure Clinics"},{"issue":"6","key":"10170_CR6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/hr.2013.30","volume":"36","author":"ML Muiesan","year":"2013","unstructured":"Muiesan, M. L., Salvetti, M., Rizzoni, D., Paini, A., Agabiti-Rosei, C., Aggiusti, C., et al. (2013). Resistant hypertension and target organ damage. Hypertension Research, 36(6), 485\u2013491. https:\/\/doi.org\/10.1038\/hr.2013.30","journal-title":"Hypertension Research"},{"key":"10170_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00559-8","author":"B Zhou","year":"2021","unstructured":"Zhou, B., Perel, P., Mensah, G. A., & Ezzati, M. (2021). Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nature Reviews. Cardiology. https:\/\/doi.org\/10.1038\/s41569-021-00559-8","journal-title":"Nature Reviews. Cardiology"},{"key":"10170_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.phrs.2017.07.026","volume":"124","author":"S Laurent","year":"2017","unstructured":"Laurent, S. (2017). Antihypertensive drugs. Pharmacological Research, 124, 116\u2013125. https:\/\/doi.org\/10.1016\/j.phrs.2017.07.026","journal-title":"Pharmacological Research"},{"issue":"18","key":"10170_CR9","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","volume":"88","author":"HA Rockman","year":"1991","unstructured":"Rockman, H. A., Ross, R. S., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., et al. (1991). Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 88(18), 8277\u20138281. https:\/\/doi.org\/10.1073\/pnas.88.18.8277","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10170_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ijcard.2016.05.071","volume":"219","author":"F Molinari","year":"2016","unstructured":"Molinari, F., Malara, N., Mollace, V., Rosano, G., & Ferraro, E. (2016). Animal models of cardiac cachexia. International Journal of Cardiology, 219, 105\u2013110. https:\/\/doi.org\/10.1016\/j.ijcard.2016.05.071","journal-title":"International Journal of Cardiology"},{"issue":"21","key":"10170_CR11","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1161\/circulationaha.113.007101","volume":"129","author":"F Laroumanie","year":"2014","unstructured":"Laroumanie, F., Douin-Echinard, V., Pozzo, J., Lairez, O., Tortosa, F., Vinel, C., et al. (2014). CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload. Circulation, 129(21), 2111\u20132124. https:\/\/doi.org\/10.1161\/circulationaha.113.007101","journal-title":"Circulation"},{"key":"10170_CR12","doi-asserted-by":"publisher","unstructured":"deAlmeida, A. C., van Oort, R. J., & Wehrens, X. H. (2010). Transverse aortic constriction in mice. Journal of Visualized Experiments: JoVE, (38). https:\/\/doi.org\/10.3791\/1729","DOI":"10.3791\/1729"},{"key":"10170_CR13","doi-asserted-by":"publisher","unstructured":"Eichhorn, L., Weisheit, C. K., Gestrich, C., Peukert, K., Duerr, G. D., Ayub, M. A., et al. (2018). A closed-chest model to induce transverse aortic constriction in mice. Journal of Visualized Experiments: JoVE, (134). https:\/\/doi.org\/10.3791\/57397","DOI":"10.3791\/57397"},{"key":"10170_CR14","doi-asserted-by":"publisher","unstructured":"Tavakoli, R., Nemska, S., Jamshidi, P., Gassmann, M., Frossard, N. (2017). Technique of minimally invasive transverse aortic constriction in mice for induction of left ventricular hypertrophy. Journal of Visualized Experiments: JoVE, (127). https:\/\/doi.org\/10.3791\/56231","DOI":"10.3791\/56231"},{"key":"10170_CR15","doi-asserted-by":"publisher","unstructured":"Zaw, A. M., Williams, C. M., Law, H. K., Chow, B. K. (2017). Minimally invasive transverse aortic constriction in mice. Journal of Visualized Experiments: JoVE, (121). https:\/\/doi.org\/10.3791\/55293","DOI":"10.3791\/55293"},{"issue":"13","key":"10170_CR16","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1056\/NEJMra072139","volume":"358","author":"JA Hill","year":"2008","unstructured":"Hill, J. A., & Olson, E. N. (2008). Cardiac plasticity. New England Journal of Medicine, 358(13), 1370\u20131380. https:\/\/doi.org\/10.1056\/NEJMra072139","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10170_CR17","doi-asserted-by":"publisher","first-page":"H552","DOI":"10.1152\/ajpheart.00212.2017","volume":"314","author":"J You","year":"2018","unstructured":"You, J., Wu, J., Zhang, Q., Ye, Y., Wang, S., Huang, J., et al. (2018). Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload. American Journal of Physiology. Heart and Circulatory Physiology, 314(3), H552\u2013H562. https:\/\/doi.org\/10.1152\/ajpheart.00212.2017","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"1","key":"10170_CR18","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41467-017-00840-w","volume":"8","author":"FL Xiang","year":"2017","unstructured":"Xiang, F. L., Fang, M., & Yutzey, K. E. (2017). Loss of \u03b2-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice. Nature Communications, 8(1), 712. https:\/\/doi.org\/10.1038\/s41467-017-00840-w","journal-title":"Nature Communications"},{"issue":"10","key":"10170_CR19","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1161\/circulationaha.110.943431","volume":"122","author":"K Toischer","year":"2010","unstructured":"Toischer, K., Rokita, A. G., Uns\u00f6ld, B., Zhu, W., Kararigas, G., Sossalla, S., et al. (2010). Differential cardiac remodeling in preload versus afterload. Circulation, 122(10), 993\u20131003. https:\/\/doi.org\/10.1161\/circulationaha.110.943431","journal-title":"Circulation"},{"issue":"9","key":"10170_CR20","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1161\/atvbaha.118.310946","volume":"38","author":"I Muthuramu","year":"2018","unstructured":"Muthuramu, I., Amin, R., Aboumsallem, J. P., Mishra, M., Robinson, E. L., & De Geest, B. (2018). Hepatocyte-specific SR-BI gene transfer corrects cardiac dysfunction in Scarb1-deficient mice and improves pressure overload-induced cardiomyopathy. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(9), 2028\u20132040. https:\/\/doi.org\/10.1161\/atvbaha.118.310946","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"4","key":"10170_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","volume":"71","author":"P Kong","year":"2014","unstructured":"Kong, P., Christia, P., & Frangogiannis, N. G. (2014). The pathogenesis of cardiac fibrosis. Cellular and Molecular Life Sciences, 71(4), 549\u2013574. https:\/\/doi.org\/10.1007\/s00018-013-1349-6","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10170_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00504-1","author":"B L\u00f3pez","year":"2021","unstructured":"L\u00f3pez, B., Ravassa, S., Moreno, M. U., Jos\u00e9, G. S., Beaumont, J., Gonz\u00e1lez, A., et al. (2021). Diffuse myocardial fibrosis: Mechanisms, diagnosis and therapeutic approaches. Nature Reviews. Cardiology. https:\/\/doi.org\/10.1038\/s41569-020-00504-1","journal-title":"Nature Reviews. Cardiology"},{"issue":"5","key":"10170_CR23","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10741-012-9346-7","volume":"18","author":"M Osterholt","year":"2013","unstructured":"Osterholt, M., Nguyen, T. D., Schwarzer, M., & Doenst, T. (2013). Alterations in mitochondrial function in cardiac hypertrophy and heart failure. Heart Failure Reviews, 18(5), 645\u2013656. https:\/\/doi.org\/10.1007\/s10741-012-9346-7","journal-title":"Heart Failure Reviews"},{"issue":"23","key":"10170_CR24","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1016\/j.jacc.2019.03.507","volume":"73","author":"G Bakris","year":"2019","unstructured":"Bakris, G., Ali, W., & Parati, G. (2019). ACC\/AHA versus ESC\/ESH on hypertension guidelines: JACC guideline comparison. Journal of the American College of Cardiology, 73(23), 3018\u20133026. https:\/\/doi.org\/10.1016\/j.jacc.2019.03.507","journal-title":"Journal of the American College of Cardiology"},{"issue":"8","key":"10170_CR25","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1073\/pnas.1714478115","volume":"115","author":"S Palmer","year":"2018","unstructured":"Palmer, S., Albergante, L., Blackburn, C. C., & Newman, T. J. (2018). Thymic involution and rising disease incidence with age. Proceedings of the National Academy of Sciences of the United States of America, 115(8), 1883\u20131888. https:\/\/doi.org\/10.1073\/pnas.1714478115","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6503","key":"10170_CR26","doi-asserted-by":"publisher","first-page":"eaba2429","DOI":"10.1126\/science.aba2429","volume":"369","author":"J Miller","year":"2020","unstructured":"Miller, J. (2020). The function of the thymus and its impact on modern medicine. Science, 369(6503), eaba2429.","journal-title":"Science"},{"issue":"1","key":"10170_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/ijmm.2018.3605","volume":"42","author":"X Dai","year":"2018","unstructured":"Dai, X., Hua, L., Chen, Y., Wang, J., Li, J., Wu, F., et al. (2018). Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review). International Journal of Molecular Medicine, 42(1), 3\u201312. https:\/\/doi.org\/10.3892\/ijmm.2018.3605","journal-title":"International Journal of Molecular Medicine"},{"issue":"3","key":"10170_CR28","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1152\/physrev.1967.47.3.437","volume":"47","author":"JF Miller","year":"1967","unstructured":"Miller, J. F., & Osoba, D. (1967). Current concepts of the immunological function of the thymus. Physiological Reviews, 47(3), 437\u2013520. https:\/\/doi.org\/10.1152\/physrev.1967.47.3.437","journal-title":"Physiological Reviews"},{"issue":"11","key":"10170_CR29","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1161\/circulationaha.114.008788","volume":"131","author":"RA Frieler","year":"2015","unstructured":"Frieler, R. A., & Mortensen, R. M. (2015). Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling. Circulation, 131(11), 1019\u20131030. https:\/\/doi.org\/10.1161\/circulationaha.114.008788","journal-title":"Circulation"},{"issue":"3","key":"10170_CR30","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1113\/ep087652","volume":"105","author":"M Takahashi","year":"2020","unstructured":"Takahashi, M., Kinugawa, S., Takada, S., Kakutani, N., Furihata, T., Sobirin, M. A., et al. (2020). The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice. Experimental Physiology, 105(3), 489\u2013501. https:\/\/doi.org\/10.1113\/ep087652","journal-title":"Experimental Physiology"},{"key":"10170_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ijcard.2018.12.076","volume":"279","author":"L Bosch","year":"2019","unstructured":"Bosch, L., de Haan, J., Seijkens, T., van Tiel, C., Brans, M., Pasterkamp, G., et al. (2019). Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure. International Journal of Cardiology, 279, 141\u2013144. https:\/\/doi.org\/10.1016\/j.ijcard.2018.12.076","journal-title":"International Journal of Cardiology"},{"issue":"8","key":"10170_CR32","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.ajpath.2020.04.006","volume":"190","author":"NA Noll","year":"2020","unstructured":"Noll, N. A., Lal, H., & Merryman, W. D. (2020). Mouse models of heart failure with preserved or reduced ejection fraction. American Journal of Pathology, 190(8), 1596\u20131608. https:\/\/doi.org\/10.1016\/j.ajpath.2020.04.006","journal-title":"American Journal of Pathology"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-021-10170-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-021-10170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T09:30:21Z","timestamp":1655803821000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-021-10170-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10170"],"URL":"https:\/\/doi.org\/10.1007\/s12265-021-10170-4","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"6 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No human studies were carried out by the authors for this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the Institutional Animal Use and Care Committee of Sun Yat-sen University (2019001114).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval for Use of Animals"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}