{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:31:32Z","timestamp":1793637092908,"version":"4.5.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12265-022-10262-9","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T20:02:28Z","timestamp":1651521748000},"page":"1424-1435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Impact of Pharmacist-Led Heart Failure Clinic on Optimization of Guideline-Directed Medical Therapy (PHARM-HF)"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-3463","authenticated-orcid":false,"given":"Tanvi","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salihah","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alamdeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Akridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida","family":"Eppes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Paarlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Parashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Jarmukli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"9","key":"10262_CR1","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","volume":"141","author":"SS Virani","year":"2020","unstructured":"Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., Djousse, L., MSV, E., Ferguson, J. F., Fornage, M., Khan, S. S., Kissela, B. M., Knutson, K. L., Kwan, T. W., Lackland, D. T., et al. (2020). American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2020 update: A report from the American Heart Association. Circulation, 141(9), e139\u2013e596.","journal-title":"Circulation"},{"issue":"3","key":"10262_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","volume":"6","author":"PA Heidenreich","year":"2013","unstructured":"Heidenreich, P. A., Albert, N. M., Allen, L. A., et al. (2013). Forecasting the impact of heart failure in the United States. Circulation Heart Failure, 6(3), 606\u2013619.","journal-title":"Circulation Heart Failure"},{"issue":"12","key":"10262_CR3","first-page":"1","volume":"11","author":"SL Jackson","year":"2018","unstructured":"Jackson, S. L., Tong, X., King, R. J., Loustalot, F., Hong, Y., & Ritchey, M. D. (2018). National burden of heart failure events in the United States, 2006 to 2014. Circulation: Heart Failure, 11(12), 1\u201312.","journal-title":"Circulation: Heart Failure"},{"issue":"6","key":"10262_CR4","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"CW Yancy","year":"2017","unstructured":"Yancy, C. W., Jessup, M., Bozkurt, B., et al. (2017). 2017 ACC\/AHA\/HFSA Focused Update of the 2013 ACCF\/AHA Guideline for the management of heart failure: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation., 136(6), e137\u2013e161.","journal-title":"Circulation."},{"issue":"6","key":"10262_CR5","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jacc.2020.11.022","volume":"77","author":"TM Maddox","year":"2021","unstructured":"Maddox, T. M., Januzzi Jr., J. L., Allen, L. A., Breathett, K., Butler, J., Davis, L. L., Fonarow, G. C., Ibrahim, N. E., Lindenfeld, J., Masoudi, F. A., Motiwala, S. R., Oliveros, E., Patterson, J. H., Walsh, M. N., Wasserman, A., Yancy, C. W., & Youmans, Q. R. (2021). 2021 Update to the 2017 ACC expert consensus decision pathway for optimization of heart failure treatment: Answers to 10 pivotal issues about heart failure with reduced ejection fraction: A report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol., 77(6), 772\u2013810.","journal-title":"J Am Coll Cardiol."},{"key":"10262_CR6","doi-asserted-by":"crossref","unstructured":"Verhestraeten, C., Heggermont, W. A., Maris, M. (2020). Clinical inertia in the treatment of heart failure: A major issue to tackle. Heart Fail Rev.","DOI":"10.1007\/s10741-020-09979-z"},{"issue":"11","key":"10262_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1409077","volume":"371","author":"JJ Mcmurray","year":"2014","unstructured":"Mcmurray, J. J., Packer, M., Desai, A. S., et al. (2014). Angiotensin\u2013neprilysin inhibition versus enalapril in heart failure. New England Journal of Medicine., 371(11), 993\u20131004.","journal-title":"New England Journal of Medicine."},{"key":"10262_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IPRP.S137882","volume":"7","author":"J Cheng","year":"2018","unstructured":"Cheng, J. (2018). Current perspectives on the role of the pharmacist in heart failure management. Integrated Pharmacy Research and Practice., 7, 1\u201311.","journal-title":"Integrated Pharmacy Research and Practice."},{"issue":"12","key":"10262_CR9","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.2146\/ajhp120267","volume":"70","author":"AS Martinez","year":"2013","unstructured":"Martinez, A. S., Saef, J., Paszczuk, A., & Bhatt-Chugani, H. (2013). Implementation of a pharmacist-managed heart failure medication titration clinic. American Journal of Health-System Pharmacy., 70(12), 1070\u20131076.","journal-title":"American Journal of Health-System Pharmacy."},{"issue":"16","key":"10262_CR10","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1001\/archinte.159.16.1939","volume":"159","author":"WA Gattis","year":"1999","unstructured":"Gattis, W. A., Hasselblad, V., Whellan, D. J., & O'connor, C. M. (1999). Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management Team. Archives of Internal Medicine., 159(16), 1939.","journal-title":"Archives of Internal Medicine."},{"issue":"1","key":"10262_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12872-017-0580-8","volume":"17","author":"OV Patterson","year":"2017","unstructured":"Patterson, O. V., Freiberg, M. S., Skanderson, M., Fodeh, J., & S, Brandt CA, DuVall SL. (2017). Unlocking echocardiogram measurements for heart disease research through natural language processing. BMC Cardiovasc Disord., 17(1), 151.","journal-title":"BMC Cardiovasc Disord."},{"issue":"5","key":"10262_CR12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.japh.2019.07.008","volume":"59","author":"OG Clay","year":"2019","unstructured":"Clay, O. G., Burn, A. L., Isetts, B. J., Hirsch, J. D., Kliethermes, M. A., & Planas, L. G. (2019). PaCIR: A tool to enhance pharmacist patient care intervention reporting. Journal of the American Pharmacists Association., 59(5), 615\u2013623.","journal-title":"Journal of the American Pharmacists Association."},{"issue":"5","key":"10262_CR13","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/CIRCOUTCOMES.115.001958","volume":"8","author":"JA Spertus","year":"2015","unstructured":"Spertus, J. A., & Jones, P. G. (2015). Development and validation of a short version of the Kansas City Cardiomyopathy Questionnaire. Circ Cardiovasc Qual Outcomes., 8(5), 469\u2013476.","journal-title":"Circ Cardiovasc Qual Outcomes."},{"key":"10262_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/ejhf.1299","volume":"21","author":"N Luo","year":"2019","unstructured":"Luo, N., O'Connor, C. M., Cooper, L. B., Sun, J.-L., Coles, A., Reed, S. D., Whellan, D. J., Pi\u00f1a, I. L., Kraus, W. E., & Mentz, R. J. (2019). Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION. Eur J Heart Fail, 21, 63\u201370.","journal-title":"Eur J Heart Fail"},{"key":"10262_CR15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1037\/0278-6133.12.2.93","volume":"12","author":"MR DiMatteo","year":"1993","unstructured":"DiMatteo, M. R., Sherbourne, C. D., Hays, R. D., Ordway, L., Kravitz, R. L., McGlynn, E. A., et al. (1993). Physicians\u2019 characteristics influence patients\u2019 adherence to medical treatment: Results from the medical outcomes study. Health Psychol., 12, 93\u2013102.","journal-title":"Health Psychol."},{"key":"10262_CR16","first-page":"50","volume":"6","author":"MR DiMatteo","year":"1992","unstructured":"DiMatteo, M. R., Hays, R. D., & Sherbourne, C. D. (1992). Adherence to cancer regimens: Implications for treating the older patient. Oncology., 6, 50\u201357.","journal-title":"Oncology."},{"issue":"1","key":"10262_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1751-7133.2012.00308.x","volume":"19","author":"CN Marti","year":"2013","unstructured":"Marti, C. N., Georgiopoulou, V. V., Giamouzis, G., et al. (2013). Patient-reported selective adherence to heart failure self-care recommendations: A prospective cohort study: The Atlanta cardiomyopathy consortium. Congest Heart Fail., 19(1), 16\u201324. https:\/\/doi.org\/10.1111\/j.1751-7133.2012.00308.x","journal-title":"Congest Heart Fail."},{"issue":"3","key":"10262_CR18","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1345\/aph.1L496","volume":"43","author":"RA Hansen","year":"2009","unstructured":"Hansen, R. A., Kim, M. M., Song, L., Tu, W., Wu, J., & Murray, M. D. (2009). Comparison of methods to assess medication adherence and classify nonadherence. Ann Pharmacother., 43(3), 413\u2013422.","journal-title":"Ann Pharmacother."},{"issue":"12","key":"10262_CR19","doi-asserted-by":"publisher","first-page":"886","DOI":"10.2146\/ajhp170186","volume":"75","author":"JA Groppi","year":"2018","unstructured":"Groppi, J. A., Ourth, H., Morreale, A. P., Hirsh, J. M., & Wright, S. (2018). Advancement of clinical pharmacy practice through intervention capture. Am J Health Syst Pharm., 75(12), 886\u2013892.","journal-title":"Am J Health Syst Pharm."},{"key":"10262_CR20","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/ejhf.2163","volume":"23","author":"AS Bhatt","year":"2021","unstructured":"Bhatt, A. S., Varshney, A. S., Nekoui, M., Moscone, A., Cunningham, J. W., Jering, K. S., Patel, P. N., Sinnenberg, L. E., Bernier, T. D., Buckley, L. F., Cook, B. M., Dempsey, J., Kelly, J., Knowles, D. M., Lupi, K., Malloy, R., Matta, L. S., Rhoten, M. N., Sharma, K., et al. (2021). Virtual optimization of guideline-directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction: The IMPLEMENT-HF pilot study. Eur J Heart Fail, 23, 1191\u20131201. https:\/\/doi.org\/10.1002\/ejhf.2163","journal-title":"Eur J Heart Fail"},{"key":"10262_CR21","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1093\/ajhp\/59.21.2070","volume":"59","author":"AJ Lee","year":"2002","unstructured":"Lee, A. J., Boro, M. S., Knapp, K. K., et al. (2002). Clinical and economic outcomes of pharmacist recommendations in a Veterans Affairs medical center. Am J Health-Syst Pharm., 59, 2070\u20132077.","journal-title":"Am J Health-Syst Pharm."},{"key":"10262_CR22","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.2146\/ajhp080660","volume":"66","author":"VE Aldridge","year":"2009","unstructured":"Aldridge, V. E., Park, H. K., Bounthavong, M., et al. (2009). Implementing a comprehensive, 24-hour emergency department pharmacy program. Am J Health-Syst Pharm., 66, 1943\u20131947.","journal-title":"Am J Health-Syst Pharm."},{"key":"10262_CR23","unstructured":"United States Department of Labor. CPI inflation calculator. www.bls.gov\/data\/inflation_calculator.htm (accessed 2021 April 30th)."},{"issue":"7","key":"10262_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.jchf.2016.01.003","volume":"4","author":"J Yoon","year":"2016","unstructured":"Yoon, J., Fonarow, G. C., Groeneveld, P. W., Teerlink, J. R., Whooley, M. A., Sahay, A., & Heidenreich, P. A. (2016). Patient and facility variation in costs of VA heart failure patients. JACC Heart Fail., 4(7), 551\u2013558. https:\/\/doi.org\/10.1016\/j.jchf.2016.01.003","journal-title":"JACC Heart Fail."},{"issue":"11","key":"10262_CR25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s40273-020-00952-0","volume":"38","author":"M Urbich","year":"2020","unstructured":"Urbich, M., Globe, G., Pantiri, K., Heisen, M., Bennison, C., Wirtz, H. S., & Di Tanna, G. L. (2020). A systematic review of medical costs associated with heart failure in the USA (2014-2020). Pharmacoeconomics., 38(11), 1219\u20131236. https:\/\/doi.org\/10.1007\/s40273-020-00952-0","journal-title":"Pharmacoeconomics."},{"issue":"Suppl 10","key":"10262_CR26","first-page":"S10","volume":"34","author":"LA Noschese","year":"2017","unstructured":"Noschese, L. A., Bergman, C. L., Brar, C. K., & Kansal, M. M. (2017). The pharmacist\u2019s role in medication optimization for patients with chronic heart failure. Fed Pract., 34(Suppl 10), S10\u2013S15.","journal-title":"Fed Pract."},{"issue":"12","key":"10262_CR27","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.2146\/ajhp120267","volume":"70","author":"AS Martinez","year":"2013","unstructured":"Martinez, A. S., Saef, J., Paszczuk, A., & Bhatt-Chugani, H. (2013). Implementation of a pharmacist-managed heart failure medication titration clinic. Am J Health Syst Pharm., 70(12), 1070\u20131076. https:\/\/doi.org\/10.2146\/ajhp120267","journal-title":"Am J Health Syst Pharm."},{"issue":"7","key":"10262_CR28","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1001\/jamacardio.2021.0496","volume":"6","author":"SJ Greene","year":"2021","unstructured":"Greene, S. J., Butler, J., & Fonarow, G. C. (2021). Simultaneous or rapid sequence initiation of quadruple medical therapy for heart failure-optimizing therapy with the need for speed. JAMA Cardiol., 6(7), 743\u2013744.","journal-title":"JAMA Cardiol."},{"key":"10262_CR29","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.105.582320","volume":"112","author":"R Willenheimer","year":"2005","unstructured":"Willenheimer, R., et al. (2005). on behalf of the CIBIS III Investigators. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: Results of the randomized cardiac insufficiency bisoprolol study (CIBIS) III. Circulation, 112, 2426\u20132435.","journal-title":"Circulation"},{"issue":"8","key":"10262_CR30","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1177\/1060028018760568","volume":"52","author":"S Bhat","year":"2018","unstructured":"Bhat, S., Kansal, M., Kondos, G. T., & Groo, V. (2018). Outcomes of a pharmacist-managed heart failure medication titration assistance clinic. Ann Pharmacother., 52(8), 724\u2013732.","journal-title":"Ann Pharmacother."},{"issue":"3","key":"10262_CR31","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/eurheartj\/ehr433","volume":"33","author":"R Lowrie","year":"2012","unstructured":"Lowrie, R., Mair, F. S., Greenlaw, N., Forsyth, P., Jhund, P. S., McConnachie, A., Rae, B., & McMurray, J. J. (2012). Heart Failure Optimal Outcomes from Pharmacy Study (HOOPS) Investigators. Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction. Eur Heart J., 33(3), 314\u2013324.","journal-title":"Eur Heart J."},{"issue":"6","key":"10262_CR32","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1002\/ehf2.12904","volume":"7","author":"M Schulz","year":"2020","unstructured":"Schulz, M., Griese-Mammen, N., Schumacher, P. M., et al. (2020). The impact of pharmacist\/physician care on quality of life in elderly heart failure patients: Results of the PHARM-CHF randomized controlled trial [published online ahead of print, 2020 Jul 23]. ESC Heart Fail., 7(6), 3310\u20133319.","journal-title":"ESC Heart Fail."},{"issue":"5","key":"10262_CR33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1001\/jamacardio.2021.0372","volume":"6","author":"SJ Greene","year":"2021","unstructured":"Greene, S. J., Butler, J., Spertus, J. A., Hellkamp, A. S., Vaduganathan, M., DeVore, A. D., Albert, N. M., Duffy, C. I., Patterson, J. H., Thomas, L., Williams, F. B., Hernandez, A. F., & Fonarow, G. C. (2021). Comparison of New York Heart Association class and patient-reported outcomes for heart failure with reduced ejection fraction. JAMA Cardiol., 6(5), 522\u2013531.","journal-title":"JAMA Cardiol."}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-022-10262-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-022-10262-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-022-10262-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:35:54Z","timestamp":1744202154000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-022-10262-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10262"],"URL":"https:\/\/doi.org\/10.1007\/s12265-022-10262-9","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]},"assertion":[{"value":"14 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Please refer to the \u201cMethods\u201d section.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable as this was a quality improvement study implemented as part of routine clinical care and waived by IRB.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Approved by appropriate institution IRB and Privacy Officer to proceed with the publication of this material.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Tanvi Patil, Salihah Ali, Alamdeep Kaur, Meghan Akridge, Davida Eppes, James Paarlberg, and Amitabh Parashar have nothing to disclose.Nabil Jarmukli  has the following conflict of interest to disclose pertaining to one of the drugs utilized in this study:KCCQ-12 Instrument for Clinical Users was purchased for use during the study duration.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}