{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:11:07Z","timestamp":1788037867196,"version":"build-2784847793"},"reference-count":135,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004735","name":"natural science foundation of\u00a0hunan province","doi-asserted-by":"publisher","award":["2020JJ4850"],"award-info":[{"award-number":["2020JJ4850"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"natural science foundation of hunan province","award":["2021JJ31026"],"award-info":[{"award-number":["2021JJ31026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12265-022-10275-4","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T15:02:38Z","timestamp":1654095758000},"page":"1283-1296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of ADAM17 in Inflammation-Related Atherosclerosis"],"prefix":"10.1007","volume":"15","author":[{"given":"Bai-Yi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-1581","authenticated-orcid":false,"given":"Juan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"10275_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1161\/ATVBAHA.112.300781","volume":"33","author":"S Wei","year":"2013","unstructured":"Wei, S., Wang, H., Zhang, G., Lu, Y., An, X., Ren, S., Wang, Y., Chen, Y., White, J. G., Zhang, C., et al. (2013). Platelet I\u03baB kinase-\u03b2 deficiency increases mouse arterial neointima formation via delayed glycoprotein Ib\u03b1 shedding. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 241\u2013248. https:\/\/doi.org\/10.1161\/ATVBAHA.112.300781","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10275_CR2","doi-asserted-by":"publisher","first-page":"C776","DOI":"10.1152\/ajpcell.00145.2019","volume":"317","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y., Wang, Y., Zhou, D., Zhang, L. S., Deng, F. X., Shu, S., Wang, L. J., Wu, Y., Guo, N., Zhou, J., & Yuan, Z. Y. (2019). Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT(1)R\/ROS\/p38 MAPK\/ADAM17 pathway. American Journal of Physiology-Cell Physiology, 317, C776-C787.\u00a0https:\/\/doi.org\/10.1152\/ajpcell.00145.2019","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"10275_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1161\/CIRCULATIONAHA.117.027612","volume":"136","author":"D Couchie","year":"2017","unstructured":"Couchie, D., Vaisman, B., Abderrazak, A., Mahmood, D. F. D., Hamza, M. M., Canesi, F., Diderot, V., El Hadri, K., N\u00e8gre-Salvayre, A., Le Page, A., et al. (2017). Human plasma Thioredoxin-80 increases with age and in ApoE(-\/-) mice induces inflammation, angiogenesis, and atherosclerosis. Circulation, 136, 464\u2013475. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.027612","journal-title":"Circulation"},{"key":"10275_CR4","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3109\/10409231003628015","volume":"45","author":"M Gooz","year":"2010","unstructured":"Gooz, M. (2010). ADAM-17: The enzyme that does it all. Critical Reviews in Biochemistry and Molecular Biology, 45, 146\u2013169.\u00a0https:\/\/doi.org\/10.3109\/10409231003628015","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"10275_CR5","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1161\/ATVBAHA.110.213124","volume":"30","author":"MM Donners","year":"2010","unstructured":"Donners, M. M., Wolfs, I. M., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G., Post, M. J., & Waltenberger, J. (2010). A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 2188\u20132195.\u00a0https:\/\/doi.org\/10.1161\/ATVBAHA.110.213124","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10275_CR6","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.3389\/fphar.2020.01154","volume":"11","author":"TM de Queiroz","year":"2020","unstructured":"de Queiroz, T. M., Lakkappa, N., & Lazartigues, E. (2020). ADAM17-mediated shedding of inflammatory cytokines in hypertension. Frontiers in Pharmacology, 11, 1154.\u00a0https:\/\/doi.org\/10.3389\/fphar.2020.01154","journal-title":"Frontiers in Pharmacology"},{"key":"10275_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrm3392","volume":"13","author":"C Adrain","year":"2012","unstructured":"Adrain, C., & Freeman, M. (2012). New lives for old: Evolution of pseudoenzyme function illustrated by iRhoms. Nature Reviews Molecular Cell Biology, 13, 489\u2013498.\u00a0https:\/\/doi.org\/10.1038\/nrm3392","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10275_CR8","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ejcb.2011.09.003","volume":"91","author":"D Dreymueller","year":"2012","unstructured":"Dreymueller, D., Pruessmeyer, J., Groth, E., & Ludwig, A. (2012). The role of ADAM-mediated shedding in vascular biology. European Journal of Cell Biology, 91, 472\u2013485.\u00a0https:\/\/doi.org\/10.1016\/j.ejcb.2011.09.003","journal-title":"European Journal of Cell Biology"},{"key":"10275_CR9","doi-asserted-by":"publisher","unstructured":"Badenes, M., & Adrain, C. (2019). iRhom2 and TNF: Partners or enemies?\u00a0Science Signaling, 12, 605, eaaz0444. https:\/\/doi.org\/10.1126\/scisignal.aaz0444","DOI":"10.1126\/scisignal.aaz0444"},{"key":"10275_CR10","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.4049\/jimmunol.160.9.4570","volume":"160","author":"IR Patel","year":"1998","unstructured":"Patel, I. R., Attur, M. G., Patel, R. N., Stuchin, S. A., Abagyan, R. A., Abramson, S. B., & Amin, A. R. (1998). TNF-alpha convertase enzyme from human arthritis-affected cartilage: Isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. The Journal of Immunology, 160, 4570\u20134579.","journal-title":"The Journal of Immunology"},{"key":"10275_CR11","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.00620.2005","volume":"291","author":"H Ohtsu","year":"2006","unstructured":"Ohtsu, H., Dempsey, P. J., & Eguchi, S. (2006). ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. American Journal of Physiology-Cell Physiology, 291, C1-10.\u00a0https:\/\/doi.org\/10.1152\/ajpcell.00620.2005","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"10275_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.molcel.2010.01.034","volume":"37","author":"P Xu","year":"2010","unstructured":"Xu, P., & Derynck, R. (2010). Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Molecular Cell, 37, 551\u2013566. https:\/\/doi.org\/10.1016\/j.molcel.2010.01.034.","journal-title":"Molecular Cell"},{"key":"10275_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/jcb.25006","volume":"116","author":"A Niu","year":"2015","unstructured":"Niu, A., Wang, B., & Li, Y. P. (2015). TNF\u03b1 shedding in mechanically stressed cardiomyocytes is mediated by Src activation of TACE. Journal of Cellular Biochemistry, 116, 559\u2013565. https:\/\/doi.org\/10.1002\/jcb.25006.","journal-title":"Journal of Cellular Biochemistry"},{"key":"10275_CR14","doi-asserted-by":"publisher","first-page":"30563","DOI":"10.1074\/jbc.274.43.30563","volume":"274","author":"ME Milla","year":"1999","unstructured":"Milla, M. E., Leesnitzer, M. A., Moss, M. L., Clay, W. C., Carter, H. L., Miller, A. B., Su, J. L., Lambert, M. H., Willard, D. H., Sheeley, D. M., et al. (1999). Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). Journal of Biological Chemistry, 274, 30563\u201330570.\u00a0https:\/\/doi.org\/10.1074\/jbc.274.43.30563","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR15","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1073\/pnas.95.7.3408","volume":"95","author":"K Maskos","year":"1998","unstructured":"Maskos, K., Fernandez-Catalan, C., Huber, R., Bourenkov, G. P., Bartunik, H., Ellestad, G. A., Reddy, P., Wolfson, M. F., Rauch, C. T., Castner, B. J., et al. (1998). Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proceedings of the National Academy of Sciences of the United States of America, 95, 3408\u20133412.\u00a0https:\/\/doi.org\/10.1073\/pnas.95.7.3408","journal-title":"Proceedings of the National Academy of Sciences U S A"},{"key":"10275_CR16","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.yjmcc.2015.10.031","volume":"93","author":"P Zhang","year":"2016","unstructured":"Zhang, P., Shen, M., Fernandez-Patron, C., & Kassiri, Z. (2016). ADAMs family and relatives in cardiovascular physiology and pathology. Journal of Molecular and Cellular Cardiology, 93, 186\u2013199.\u00a0https:\/\/doi.org\/10.1016\/j.yjmcc.2015.10.031","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10275_CR17","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.4049\/jimmunol.178.7.4214","volume":"178","author":"N Li","year":"2007","unstructured":"Li, N., Boyd, K., Dempsey, P. J., & Vignali, D. A. (2007). Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. The Journal of Immunology, 178, 4214\u20134221.\u00a0https:\/\/doi.org\/10.4049\/jimmunol.178.7.4214","journal-title":"The Journal of Immunology"},{"key":"10275_CR18","doi-asserted-by":"publisher","first-page":"6962","DOI":"10.1093\/emboj\/18.24.6962","volume":"18","author":"H Fan","year":"1999","unstructured":"Fan, H., & Derynck, R. (1999). Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO Journal, 18, 6962\u20136972.\u00a0https:\/\/doi.org\/10.1093\/emboj\/18.24.6962","journal-title":"EMBO Journal"},{"key":"10275_CR19","doi-asserted-by":"publisher","first-page":"28828","DOI":"10.1074\/jbc.274.40.28828","volume":"274","author":"Z Gechtman","year":"1999","unstructured":"Gechtman, Z., Alonso, J. L., Raab, G., Ingber, D. E., & Klagsbrun, M. (1999). The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf\/mitogen-activated protein kinase cascade and by cell adhesion and spreading. Journal of Biological Chemistry, 274, 28828\u201328835.\u00a0https:\/\/doi.org\/10.1074\/jbc.274.40.28828","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR20","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0092-8674(00)81408-7","volume":"92","author":"J Kahn","year":"1998","unstructured":"Kahn, J., Walcheck, B., Migaki, G. I., Jutila, M. A., & Kishimoto, T. K. (1998). Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism. Cell, 92, 809\u2013818.\u00a0https:\/\/doi.org\/10.1016\/s0092-8674(00)81408-7","journal-title":"Cell"},{"key":"10275_CR21","doi-asserted-by":"publisher","first-page":"14608","DOI":"10.1074\/jbc.275.19.14608","volume":"275","author":"P Reddy","year":"2000","unstructured":"Reddy, P., Slack, J. L., Davis, R., Cerretti, D. P., Kozlosky, C. J., Blanton, R. A., Shows, D., Peschon, J. J., & Black, R. A. (2000). Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. Journal of Biological Chemistry, 275, 14608\u201314614.\u00a0https:\/\/doi.org\/10.1074\/jbc.275.19.14608","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR22","doi-asserted-by":"publisher","first-page":"18617","DOI":"10.1074\/jbc.M300331200","volume":"278","author":"H Fan","year":"2003","unstructured":"Fan, H., Turck, C. W., & Derynck, R. (2003). Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. Journal of Biological Chemistry, 278, 18617\u201318627.\u00a0https:\/\/doi.org\/10.1074\/jbc.M300331200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR23","doi-asserted-by":"publisher","first-page":"31638","DOI":"10.1074\/jbc.M401311200","volume":"279","author":"PE Gonzales","year":"2004","unstructured":"Gonzales, P. E., Solomon, A., Miller, A. B., Leesnitzer, M. A., Sagi, I., & Milla, M. E. (2004). Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. Journal of Biological Chemistry, 279, 31638\u201331645.\u00a0https:\/\/doi.org\/10.1074\/jbc.M401311200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR24","doi-asserted-by":"publisher","first-page":"27365","DOI":"10.1074\/jbc.M401690200","volume":"279","author":"X Li","year":"2004","unstructured":"Li, X., & Fan, H. (2004). Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich\/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). Journal of Biological Chemistry, 279, 27365\u201327375.\u00a0https:\/\/doi.org\/10.1074\/jbc.M401690200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR25","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/385729a0","volume":"385","author":"RA Black","year":"1997","unstructured":"Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997). A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature, 385, 729\u2013733.\u00a0https:\/\/doi.org\/10.1038\/385729a0","journal-title":"Nature"},{"key":"10275_CR26","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1046\/j.1432-1327.2001.02085.x","volume":"268","author":"T Itai","year":"2001","unstructured":"Itai, T., Tanaka, M., & Nagata, S. (2001). Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form. European Journal of Biochemistry, 268, 2074\u20132082.\u00a0https:\/\/doi.org\/10.1046\/j.1432-1327.2001.02085.x","journal-title":"European Journal of Biochemistry"},{"key":"10275_CR27","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/385733a0","volume":"385","author":"ML Moss","year":"1997","unstructured":"Moss, M. L., Jin, S. L., Milla, M. E., Bickett, D. M., Burkhart, W., Carter, H. L., Chen, W. J., Clay, W. C., Didsbury, J. R., Hassler, D., et al. (1997). Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature, 385, 733\u2013736.\u00a0https:\/\/doi.org\/10.1038\/385733a0","journal-title":"Nature"},{"key":"10275_CR28","doi-asserted-by":"publisher","first-page":"6641","DOI":"10.1074\/jbc.RA119.011192","volume":"295","author":"J Yang","year":"2020","unstructured":"Yang, J., LeBlanc, M. E., Cano, I., Saez-Torres, K. L., Saint-Geniez, M., Ng, Y. S., & D\u2019Amore, P. A. (2020). ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. Journal of Biological Chemistry, 295, 6641\u20136651.\u00a0https:\/\/doi.org\/10.1074\/jbc.RA119.011192","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yjmcc.2016.12.001","volume":"103","author":"M Shen","year":"2017","unstructured":"Shen, M., Morton, J., Davidge, S. T., & Kassiri, Z. (2017). Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage. Journal of Molecular and Cellular Cardiology, 103, 11\u201321.\u00a0https:\/\/doi.org\/10.1016\/j.yjmcc.2016.12.001","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10275_CR30","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1016\/j.bbamcr.2016.09.002","volume":"1863","author":"E Groth","year":"2016","unstructured":"Groth, E., Pruessmeyer, J., Babendreyer, A., Schumacher, J., Pasqualon, T., Dreymueller, D., Higashiyama, S., Lorenzen, I., Gr\u00f6tzinger, J., Cataldo, D., & Ludwig, A. (2016). Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes. Biochimica et Biophysica Acta, 1863, 2795\u20132808.\u00a0https:\/\/doi.org\/10.1016\/j.bbamcr.2016.09.002","journal-title":"Biochimica et Biophysica Acta"},{"key":"10275_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.612808","volume":"7","author":"R Geesala","year":"2020","unstructured":"Geesala, R., Issuree, P. D., & Maretzky, T. (2020). The role of iRhom2 in metabolic and cardiovascular-related disorders. Frontiers in Cardiovascular Medicine, 7, 612808.\u00a0https:\/\/doi.org\/10.3389\/fcvm.2020.612808","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10275_CR32","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1083\/jcb.143.5.1317","volume":"143","author":"HS Wiley","year":"1998","unstructured":"Wiley, H. S., Woolf, M. F., Opresko, L. K., Burke, P. M., Will, B., Morgan, J. R., & Lauffenburger, D. A. (1998). Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization. Journal of Cell Biology, 143, 1317\u20131328.\u00a0https:\/\/doi.org\/10.1083\/jcb.143.5.1317","journal-title":"Journal of Cell Biology"},{"key":"10275_CR33","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/emboj\/cdg111","volume":"22","author":"M Borrell-Pag\u00e8s","year":"2003","unstructured":"Borrell-Pag\u00e8s, M., Rojo, F., Albanell, J., Baselga, J., & Arribas, J. (2003). TACE is required for the activation of the EGFR by TGF-alpha in tumors. EMBO Journal, 22, 1114\u20131124.\u00a0https:\/\/doi.org\/10.1093\/emboj\/cdg111","journal-title":"EMBO Journal"},{"key":"10275_CR34","doi-asserted-by":"publisher","first-page":"11221","DOI":"10.1021\/bi960618e","volume":"35","author":"G Galazka","year":"1996","unstructured":"Galazka, G., Windsor, L. J., Birkedal-Hansen, H., & Engler, J. A. (1996). APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide. Biochemistry, 35, 11221\u201311227.\u00a0https:\/\/doi.org\/10.1021\/bi960618e","journal-title":"Biochemistry"},{"key":"10275_CR35","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1073\/pnas.87.14.5578","volume":"87","author":"HE Van Wart","year":"1990","unstructured":"Van Wart, H. E., & Birkedal-Hansen, H. (1990). The cysteine switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proceedings of the National Academy of Sciences U S A, 87, 5578\u20135582.\u00a0https:\/\/doi.org\/10.1073\/pnas.87.14.5578","journal-title":"Proceedings of the National Academy of Sciences U S A"},{"key":"10275_CR36","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1074\/jbc.274.6.3531","volume":"274","author":"M Roghani","year":"1999","unstructured":"Roghani, M., Becherer, J. D., Moss, M. L., Atherton, R. E., Erdjument-Bromage, H., Arribas, J., Blackburn, R. K., Weskamp, G., Tempst, P., & Blobel, C. P. (1999). Metalloprotease-disintegrin MDC9: Intracellular maturation and catalytic activity. Journal of Biological Chemistry, 274, 3531\u20133540.\u00a0https:\/\/doi.org\/10.1074\/jbc.274.6.3531","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR37","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.semcdb.2008.11.002","volume":"20","author":"K Reiss","year":"2009","unstructured":"Reiss, K., & Saftig, P. (2009). The \u201ca disintegrin and metalloprotease\u201d (ADAM) family of sheddases: Physiological and cellular functions. Seminars in Cell & Developmental Biology, 20, 126\u2013137.\u00a0https:\/\/doi.org\/10.1016\/j.semcdb.2008.11.002","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"10275_CR38","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0014-5793(00)01528-3","volume":"473","author":"A Amour","year":"2000","unstructured":"Amour, A., Knight, C. G., Webster, A., Slocombe, P. M., Stephens, P. E., Kn\u00e4uper, V., Docherty, A. J., & Murphy, G. (2000). The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Letters, 473, 275\u2013279.\u00a0https:\/\/doi.org\/10.1016\/s0014-5793(00)01528-3","journal-title":"FEBS Letters"},{"key":"10275_CR39","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/ng0904-934","volume":"36","author":"RA Black","year":"2004","unstructured":"Black, R. A. (2004). TIMP3 checks inflammation. Nature Genetics, 36, 934\u2013935.\u00a0https:\/\/doi.org\/10.1038\/ng0904-934","journal-title":"Nature Genetics"},{"key":"10275_CR40","doi-asserted-by":"publisher","first-page":"42463","DOI":"10.1074\/jbc.M207459200","volume":"277","author":"Y Zheng","year":"2002","unstructured":"Zheng, Y., Schlondorff, J., & Blobel, C. P. (2002). Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. Journal of Biological Chemistry, 277, 42463\u201342470.\u00a0https:\/\/doi.org\/10.1074\/jbc.M207459200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR41","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.atherosclerosis.2014.05.946","volume":"235","author":"R St\u00f6hr","year":"2014","unstructured":"St\u00f6hr, R., Cavalera, M., Menini, S., Mavilio, M., Casagrande, V., Rossi, C., Urbani, A., Cardellini, M., Pugliese, G., Menghini, R., & Federici, M. (2014). Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice. Atherosclerosis, 235, 438\u2013443.\u00a0https:\/\/doi.org\/10.1016\/j.atherosclerosis.2014.05.946","journal-title":"Atherosclerosis"},{"key":"10275_CR42","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1172\/JCI26052","volume":"115","author":"M Federici","year":"2005","unstructured":"Federici, M., Hribal, M. L., Menghini, R., Kanno, H., Marchetti, V., Porzio, O., Sunnarborg, S. W., Rizza, S., Serino, M., Cunsolo, V., et al. (2005). Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. The Journal of Clinical Investigation, 115, 3494\u20133505.\u00a0https:\/\/doi.org\/10.1172\/JCI26052","journal-title":"The Journal of Clinical Investigation"},{"key":"10275_CR43","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1101\/gad.543109","volume":"23","author":"J Guinea-Viniegra","year":"2009","unstructured":"Guinea-Viniegra, J., Zenz, R., Scheuch, H., Hnisz, D., Holcmann, M., Bakiri, L., Schonthaler, H. B., Sibilia, M., & Wagner, E. F. (2009). TNFalpha shedding and epidermal inflammation are controlled by Jun proteins. Genes & Development, 23, 2663\u20132674.\u00a0https:\/\/doi.org\/10.1101\/gad.543109","journal-title":"Genes & Development"},{"key":"10275_CR44","doi-asserted-by":"publisher","first-page":"44083","DOI":"10.1074\/jbc.M112.425652","volume":"287","author":"R Basu","year":"2012","unstructured":"Basu, R., Fan, D., Kandalam, V., Lee, J., Das, S. K., Wang, X., Baldwin, T. A., Oudit, G. Y., & Kassiri, Z. (2012). Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. Journal of Biological Chemistry, 287, 44083\u201344096.\u00a0https:\/\/doi.org\/10.1074\/jbc.M112.425652","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR45","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1242\/jcs.02357","volume":"118","author":"SM Soond","year":"2005","unstructured":"Soond, S. M., Everson, B., Riches, D. W., & Murphy, G. (2005). ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. Journal of Cell Science, 118, 2371\u20132380.\u00a0https:\/\/doi.org\/10.1242\/jcs.02357","journal-title":"Journal of Cell Science"},{"key":"10275_CR46","doi-asserted-by":"publisher","first-page":"25024","DOI":"10.1074\/jbc.M110.102566","volume":"285","author":"K Mendelson","year":"2010","unstructured":"Mendelson, K., Swendeman, S., Saftig, P., & Blobel, C. P. (2010). Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways. Journal of Biological Chemistry, 285, 25024\u201325032.\u00a0https:\/\/doi.org\/10.1074\/jbc.M110.102566","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR47","doi-asserted-by":"publisher","unstructured":"Li, R., Wang, T., Walia, K., Gao, B., & Krepinsky, J. C. (2018). Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK. Journal of Cell Science, 131, jcs208629. https:\/\/doi.org\/10.1242\/jcs.208629","DOI":"10.1242\/jcs.208629"},{"key":"10275_CR48","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.biocel.2018.07.011","volume":"102","author":"S Siddharth","year":"2018","unstructured":"Siddharth, S., Nayak, A., Das, S., Nayak, D., Panda, J., Wyatt, M. D., & Kundu, C. N. (2018). The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-\u03b24. International Journal of Biochemistry & Cell Biology, 102, 151\u2013160.\u00a0https:\/\/doi.org\/10.1016\/j.biocel.2020.105860","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10275_CR49","doi-asserted-by":"publisher","unstructured":"Ding, X. F., Liang, H. Y., Sun, J. Y., Liu, S. H., Kan, Q. C., Wang, L. X., & Sun, T. W. (2019). Adipose-derived mesenchymal stem cells ameliorate the inflammatory reaction in CLP-induced septic acute lung injury rats via sTNFR1. Journal of Cellular Physiology, 234, 16582\u201316591. https:\/\/doi.org\/10.1002\/jcp.28329","DOI":"10.1002\/jcp.28329"},{"key":"10275_CR50","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1002\/ptr.6603","volume":"34","author":"H Wang","year":"2020","unstructured":"Wang, H., Yuan, R., Cao, Q., Wang, M., Ren, D., Huang, X., Wu, M., Zhang, L., Zhao, X., Huo, X., et al. (2020). Astragaloside III activates TACE\/ADAM17-dependent anti-inflammatory and growth factor signaling in endothelial cells in a p38-dependent fashion. Phytotherapy Research, 34, 1096\u20131107. https:\/\/doi.org\/10.1002\/ptr.6603","journal-title":"Phytotherapy Research"},{"key":"10275_CR51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.phrs.2016.11.025","volume":"115","author":"Z Szondy","year":"2017","unstructured":"Szondy, Z., & Pallai, A. (2017). Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications. Pharmacological Research, 115, 124\u2013132.\u00a0https:\/\/doi.org\/10.1016\/j.phrs.2016.11.025","journal-title":"Pharmacological Research"},{"key":"10275_CR52","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41419-019-1808-6","volume":"10","author":"C Li","year":"2019","unstructured":"Li, C., Gu, H., Yu, M., Yang, P., Zhang, M., Ba, H., Yin, Y., Wang, J., Yin, B., Zhou, X., & Li, Z. (2019). Inhibition of transmembrane TNF-\u03b1 shedding by a specific antibody protects against septic shock. Cell Death & Disease, 10, 586.\u00a0https:\/\/doi.org\/10.1038\/s41419-019-1808-6","journal-title":"Cell Death & Disease"},{"key":"10275_CR53","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.3892\/mmr.2017.7307","volume":"16","author":"B He","year":"2017","unstructured":"He, B., Li, X., Hu, T., Lian, W., & Zhang, M. (2017). Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice. Molecular Medicine Reports, 16, 6013\u20136019.\u00a0https:\/\/doi.org\/10.3892\/mmr.2017.7307","journal-title":"Molecular Medicine Reports"},{"key":"10275_CR54","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","volume":"10","author":"H Wajant","year":"2003","unstructured":"Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death and Differentiation, 10, 45\u201365.\u00a0https:\/\/doi.org\/10.1038\/sj.cdd.4401189","journal-title":"Cell Death and Differentiation"},{"key":"10275_CR55","doi-asserted-by":"publisher","unstructured":"Kotyla, P. J. (2018). Bimodal function of anti-TNF treatment: shall we be concerned about anti-TNF treatment in patients with rheumatoid arthritis and heart failure?\u00a0International Journal of Molecular Sciences, 19, 1739. https:\/\/doi.org\/10.3390\/ijms19061739","DOI":"10.3390\/ijms19061739"},{"key":"10275_CR56","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12974-020-01941-y","volume":"17","author":"YM Arenas","year":"2020","unstructured":"Arenas, Y. M., Cabrera-Pastor, A., Juciute, N., Mora-Navarro, E., & Felipo, V. (2020). Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-\u03ba\u03b2 pathway. Journal of Neuroinflammation, 17, 269.\u00a0https:\/\/doi.org\/10.1186\/s12974-020-01941-y","journal-title":"Journal of Neuroinflammation"},{"key":"10275_CR57","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1161\/ATVBAHA.116.308682","volume":"37","author":"A Nicolaou","year":"2017","unstructured":"Nicolaou, A., Zhao, Z., Northoff, B. H., Sass, K., Herbst, A., Kohlmaier, A., Chalaris, A., Wolfrum, C., Weber, C., Steffens, S., et al. (2017). Adam17 deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 247\u2013257.\u00a0https:\/\/doi.org\/10.1161\/ATVBAHA.116.308682","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10275_CR58","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/14728222.2019.1586886","volume":"23","author":"J Medler","year":"2019","unstructured":"Medler, J., & Wajant, H. (2019). Tumor necrosis factor receptor-2 (TNFR2): An overview of an emerging drug target. Expert Opinion on Therapeutic Targets, 23, 295\u2013307.\u00a0https:\/\/doi.org\/10.1080\/14728222.2019.1586886","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"10275_CR59","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1172\/JCI121372","volume":"129","author":"D Sharma","year":"2019","unstructured":"Sharma, D., Malik, A., Guy, C., Vogel, P., & Kanneganti, T. D. (2019). TNF\/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. The Journal of Clinical Investigation, 129, 150\u2013162.\u00a0https:\/\/doi.org\/10.1172\/JCI121372","journal-title":"The Journal of Clinical Investigation"},{"key":"10275_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.04.002","volume":"215","author":"S D\u00fcsterh\u00f6ft","year":"2019","unstructured":"D\u00fcsterh\u00f6ft, S., Lokau, J., & Garbers, C. (2019). The metalloprotease ADAM17 in inflammation and cancer. Pathology, Research and Practice, 215, 152410.\u00a0https:\/\/doi.org\/10.1016\/j.prp.2019.04.002","journal-title":"Pathology, Research and Practice"},{"key":"10275_CR61","doi-asserted-by":"publisher","unstructured":"Schumacher, N., & Rose-John, S. (2019). ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer. Cancers, 11, 1736. https:\/\/doi.org\/10.3390\/cancers11111736","DOI":"10.3390\/cancers11111736"},{"key":"10275_CR62","doi-asserted-by":"publisher","unstructured":"Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., et al. (2019). ADAM17 selectively activates the IL-6 trans-signaling\/ERK MAPK axis in KRAS-addicted lung cancer. EMBO Molecular Medicine, 11, e9976. https:\/\/doi.org\/10.15252\/emmm.201809976","DOI":"10.15252\/emmm.201809976"},{"key":"10275_CR63","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12964-018-0268-4","volume":"16","author":"MM Zegeye","year":"2018","unstructured":"Zegeye, M. M., Lindkvist, M., F\u00e4lker, K., Kumawat, A. K., Paramel, G., Greneg\u00e5rd, M., Sirsj\u00f6, A., & Ljungberg, L. U. (2018). Activation of the JAK\/STAT3 and PI3K\/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling: CCS, 16, 55.\u00a0https:\/\/doi.org\/10.1186\/s12964-018-0268-4","journal-title":"Cell Communication and Signaling: CCS"},{"key":"10275_CR64","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1038\/s41596-019-0213-z","volume":"14","author":"RA Wimmer","year":"2019","unstructured":"Wimmer, R. A., Leopoldi, A., Aichinger, M., Kerjaschki, D., & Penninger, J. M. (2019). Generation of blood vessel organoids from human pluripotent stem cells. Nature Protocols, 14, 3082\u20133100.\u00a0https:\/\/doi.org\/10.1038\/s41596-019-0213-z","journal-title":"Nature Protocols"},{"key":"10275_CR65","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3389\/fcimb.2017.00138","volume":"7","author":"HK Mishra","year":"2017","unstructured":"Mishra, H. K., Ma, J., & Walcheck, B. (2017). Ectodomain shedding by ADAM17: Its role in neutrophil recruitment and the impairment of this process during sepsis. Frontiers in Cellular and Infection Microbiology, 7, 138.\u00a0https:\/\/doi.org\/10.3389\/fcimb.2017.00138","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10275_CR66","doi-asserted-by":"publisher","unstructured":"Shalaby, L., Thounaojam, M., Tawfik, A., Li, J., Hussein, K., Jahng, W. J., Al-Shabrawey, M., Kwok, H. F., Bartoli, M., & Gutsaeva, D. (2020). Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy. Journal of Clinical Medicine, 9, 400. https:\/\/doi.org\/10.3390\/jcm9020400","DOI":"10.3390\/jcm9020400"},{"key":"10275_CR67","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ebiom.2019.09.041","volume":"49","author":"G Lian","year":"2019","unstructured":"Lian, G., Li, X., Zhang, L., Zhang, Y., Sun, L., Zhang, X., Liu, H., Pang, Y., Kong, W., Zhang, T., et al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1\u03b1-ADAM17 pathway(\u2730). eBioMedicine, 49, 291\u2013304.\u00a0https:\/\/doi.org\/10.1016\/j.ebiom.2019.09.041","journal-title":"eBioMedicine"},{"key":"10275_CR68","doi-asserted-by":"publisher","first-page":"2109352","DOI":"10.1155\/2018\/2109352","volume":"2018","author":"SY Zeng","year":"2018","unstructured":"Zeng, S. Y., Yang, L., Hong, C. L., Lu, H. Q., Yan, Q. J., Chen, Y., & Qin, X. P. (2018). Evidence that ADAM17 mediates the protective action of CGRP against angiotensin II-induced inflammation in vascular smooth muscle cells. Mediators of Inflammation, 2018, 2109352.\u00a0https:\/\/doi.org\/10.1155\/2018\/2109352","journal-title":"Mediators of Inflammation"},{"key":"10275_CR69","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1161\/CIRCRESAHA.118.313181","volume":"123","author":"M Shen","year":"2018","unstructured":"Shen, M., Hu, M., Fedak, P. W. M., Oudit, G. Y., & Kassiri, Z. (2018). Cell-specific functions of ADAM17 regulate the progression of thoracic aortic aneurysm. Circulation Research, 123, 372\u2013388.\u00a0https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313181","journal-title":"Circulation Research"},{"key":"10275_CR70","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.3389\/fimmu.2019.02326","volume":"10","author":"HG Gebremariam","year":"2019","unstructured":"Gebremariam, H. G., Qazi, K. R., Somiah, T., Pathak, S. K., Sj\u00f6linder, H., Sverremark Ekstr\u00f6m, E., & Jonsson, A. B. (2019). Lactobacillus gasseri suppresses the production of proinflammatory cytokines in Helicobacter pylori-infected macrophages by inhibiting the expression of ADAM17. Frontiers in Immunology, 10, 2326.\u00a0https:\/\/doi.org\/10.3389\/fimmu.2019.02326","journal-title":"Frontiers in Immunology"},{"key":"10275_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118222","volume":"258","author":"C Zhou","year":"2020","unstructured":"Zhou, C., Qin, Y., Chen, R., Gao, F., Zhang, J., & Lu, F. (2020). Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2\/TACE. Life Sciences, 258, 118222.\u00a0https:\/\/doi.org\/10.1016\/j.lfs.2020.118222","journal-title":"Life Sciences"},{"key":"10275_CR72","doi-asserted-by":"publisher","unstructured":"Mishra, H. K., Ma, J., Mendez, D., Hullsiek, R., Pore, N., & Walcheck, B. (2020). Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis. International Journal of Molecular Sciences, 21, 6688. https:\/\/doi.org\/10.3390\/ijms21186688","DOI":"10.3390\/ijms21186688"},{"key":"10275_CR73","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cbin.10885","volume":"42","author":"Y Wang","year":"2018","unstructured":"Wang, Y., Chen, L., Tian, Z., Shen, X., Wang, X., Wu, H., Wang, Y., Zou, J., & Liang, J. (2018). CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Cell Biology International, 42, 187\u2013193.\u00a0https:\/\/doi.org\/10.1002\/cbin.10885","journal-title":"Cell Biology International"},{"key":"10275_CR74","doi-asserted-by":"publisher","first-page":"7627","DOI":"10.18632\/aging.202660","volume":"13","author":"C Mao","year":"2021","unstructured":"Mao, C., Li, D., Zhou, E., Zhang, J., Wang, C., & Xue, C. (2021). Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway. Aging (Albany NY), 13, 7627\u20137643.\u00a0https:\/\/doi.org\/10.18632\/aging.202660","journal-title":"Aging (Albany NY)"},{"key":"10275_CR75","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/cvr\/cvab041","volume":"118","author":"C Hannemann","year":"2022","unstructured":"Hannemann, C., Schecker, J. H., Brettschneider, A., Grune, J., R\u00f6sener, N., Weller, A., Stangl, V., Fisher, E. A., Stangl, K., Ludwig, A., & Hewing, B. (2022). Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidaemia and early atherogenesis. Cardiovascular Research, 118, 156\u2013168.\u00a0https:\/\/doi.org\/10.1093\/cvr\/cvab041","journal-title":"Cardiovascular Research"},{"key":"10275_CR76","doi-asserted-by":"publisher","unstructured":"Tang, J., Frey, J. M., Wilson, C. L., Moncada-Pazos, A., Levet, C., Freeman, M., Rosenfeld, M. E., Stanley, E. R., Raines, E. W., & Bornfeldt, K. E. (2018). Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation. Molecular and Cellular Biology, 38, e00103\u201318. https:\/\/doi.org\/10.1128\/MCB.00103-18","DOI":"10.1128\/MCB.00103-18"},{"key":"10275_CR77","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.atherosclerosis.2016.05.029","volume":"252","author":"S Sakamuri","year":"2016","unstructured":"Sakamuri, S., Higashi, Y., Sukhanov, S., Siddesha, J. M., Delafontaine, P., Siebenlist, U., & Chandrasekar, B. (2016). TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-\/-) mice. Atherosclerosis, 252, 153\u2013160.\u00a0https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.05.029","journal-title":"Atherosclerosis"},{"key":"10275_CR78","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/ATVBAHA.116.308840","volume":"37","author":"Y Jia","year":"2017","unstructured":"Jia, Y., & Kong, W. (2017). ADAM17: A molecular switch to control TNFR2 during atherogenesis in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 176\u2013178.\u00a0https:\/\/doi.org\/10.1161\/ATVBAHA.116.308840","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10275_CR79","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.atherosclerosis.2015.01.029","volume":"239","author":"S Rizza","year":"2015","unstructured":"Rizza, S., Copetti, M., Cardellini, M., Menghini, R., Pecchioli, C., Luzi, A., Di Cola, G., Porzio, O., Ippoliti, A., Romeo, F., et al. (2015). A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis. Atherosclerosis, 239, 459\u2013464.\u00a0https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.01.029","journal-title":"Atherosclerosis"},{"key":"10275_CR80","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2353\/ajpath.2007.070021","volume":"171","author":"M Canault","year":"2007","unstructured":"Canault, M., Leroyer, A. S., Peiretti, F., Les\u00e8che, G., Tedgui, A., Bonardo, B., Alessi, M. C., Boulanger, C. M., & Nalbone, G. (2007). Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme\/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. American Journal of Pathology, 171, 1713\u20131723.\u00a0https:\/\/doi.org\/10.2353\/ajpath.2007.070021","journal-title":"American Journal of Pathology"},{"key":"10275_CR81","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1136\/heartjnl-2018-314230","volume":"106","author":"N Ruparelia","year":"2020","unstructured":"Ruparelia, N., & Choudhury, R. (2020). Inflammation and atherosclerosis: What is on the horizon? Heart, 106, 80\u201385.\u00a0https:\/\/doi.org\/10.1136\/heartjnl-2018-314230","journal-title":"Heart"},{"key":"10275_CR82","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3945\/jn.115.211375","volume":"145","author":"N Speck","year":"2015","unstructured":"Speck, N., Brandsch, C., Schmidt, N., Yazdekhasti, N., Hirche, F., Lucius, R., Rimbach, G., Stangl, G. I., & Reiss, K. (2015). The antiatherogenic effect of fish oil in male mice is associated with a diminished release of endothelial ADAM17 and ADAM10 substrates. Journal of Nutrition, 145, 1218\u20131226.\u00a0https:\/\/doi.org\/10.3945\/jn.115.211375","journal-title":"Journal of Nutrition"},{"key":"10275_CR83","doi-asserted-by":"publisher","first-page":"592048","DOI":"10.3389\/fcell.2020.592048","volume":"8","author":"J Liao","year":"2020","unstructured":"Liao, J., An, X., Yang, X., Lin, Q. Y., Liu, S., Xie, Y., Bai, J., Xia, Y. L., & Li, H. H. (2020). Deficiency of LMP10 attenuates diet-induced atherosclerosis by inhibiting macrophage polarization and inflammation in apolipoprotein E deficient mice. Frontiers in Cell Developmental Biology, 8, 592048.\u00a0https:\/\/doi.org\/10.3389\/fcell.2020.592048","journal-title":"Frontiers in Cell Developmental Biology"},{"key":"10275_CR84","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.atherosclerosis.2005.08.031","volume":"187","author":"M Canault","year":"2006","unstructured":"Canault, M., Peiretti, F., Kopp, F., Bonardo, B., Bonzi, M. F., Coudeyre, J. C., Alessi, M. C., Juhan-Vague, I., & Nalbone, G. (2006). The TNF alpha converting enzyme (TACE\/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: Possible contribution to elevated plasma levels of soluble TNF alpha receptors. Atherosclerosis, 187, 82\u201391.\u00a0https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.08.031","journal-title":"Atherosclerosis"},{"key":"10275_CR85","doi-asserted-by":"publisher","first-page":"17939","DOI":"10.1038\/srep17939","volume":"5","author":"X Zhao","year":"2015","unstructured":"Zhao, X., Kong, J., Zhao, Y., Wang, X., Bu, P., Zhang, C., & Zhang, Y. (2015). Gene silencing of TACE enhances plaque stability and improves vascular remodeling in a rabbit model of atherosclerosis. Science and Reports, 5, 17939.\u00a0https:\/\/doi.org\/10.1038\/srep17939","journal-title":"Science and Reports"},{"key":"10275_CR86","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1021\/acsnano.7b01385","volume":"11","author":"TJ Beldman","year":"2017","unstructured":"Beldman, T. J., Senders, M. L., Alaarg, A., P\u00e9rez-Medina, C., Tang, J., Zhao, Y., Fay, F., Deichm\u00f6ller, J., Born, B., Desclos, E., et al. (2017). Hyaluronan nanoparticles selectively target plaque-associated macrophages and improve plaque stability in atherosclerosis. ACS Nano, 11, 5785\u20135799.\u00a0https:\/\/doi.org\/10.1021\/acsnano.7b01385","journal-title":"ACS Nano"},{"key":"10275_CR87","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/cvr\/cvy007","volume":"114","author":"MOJ Grootaert","year":"2018","unstructured":"Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y. (2018). Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis. Cardiovascular Research, 114, 622\u2013634.\u00a0https:\/\/doi.org\/10.1093\/cvr\/cvy007","journal-title":"Cardiovascular Research"},{"key":"10275_CR88","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.peptides.2017.01.013","volume":"90","author":"L Wang","year":"2017","unstructured":"Wang, L., Chen, Q., Ke, D., & Li, G. (2017). Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model. Peptides, 90, 17\u201326.\u00a0https:\/\/doi.org\/10.1016\/j.peptides.2017.01.013","journal-title":"Peptides"},{"key":"10275_CR89","doi-asserted-by":"publisher","first-page":"596340","DOI":"10.3389\/fninf.2020.596340","volume":"14","author":"Z Li","year":"2020","unstructured":"Li, Z., Wang, Y., Wu, X., Liu, X., Huang, S., He, Y., Liu, S., & Ren, L. (2020). Studying the factors of human carotid atherosclerotic plaque rupture, by calculating stress\/strain in the plaque, based on CEUS images: A numerical study. Frontiers in Neuroinformatics, 14, 596340.\u00a0https:\/\/doi.org\/10.3389\/fninf.2020.596340","journal-title":"Frontiers in Neuroinformatics"},{"key":"10275_CR90","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10456-014-9443-4","volume":"18","author":"V Caolo","year":"2015","unstructured":"Caolo, V., Swennen, G., Chalaris, A., Wagenaar, A., Verbruggen, S., Rose-John, S., Molin, D. G., Vooijs, M., & Post, M. J. (2015). ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis. Angiogenesis, 18, 13\u201322.\u00a0https:\/\/doi.org\/10.1007\/s10456-014-9443-4","journal-title":"Angiogenesis"},{"key":"10275_CR91","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/07853890802649738","volume":"41","author":"N Oksala","year":"2009","unstructured":"Oksala, N., Levula, M., Airla, N., Pelto-Huikko, M., Ortiz, R. M., J\u00e4rvinen, O., Salenius, J. P., Ozsait, B., Komurcu-Bayrak, E., Erginel-Unaltuna, N., et al. (2009). ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries\u2013Tampere vascular study. Annals of Medicine, 41, 279\u2013290.\u00a0https:\/\/doi.org\/10.1080\/07853890802649738","journal-title":"Annals of Medicine"},{"key":"10275_CR92","doi-asserted-by":"publisher","first-page":"671","DOI":"10.32687\/0869-866X-2019-27-si1-671-676","volume":"27","author":"NG Poteshkina","year":"2019","unstructured":"Poteshkina, N. G., Kovalevskaya, E. A., Krylova, N. S., & Fettser, D. V. (2019). Myocardial ischemia in patients with hypertrophic cardiomyopathy. Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med, 27, 671\u2013676.\u00a0https:\/\/doi.org\/10.32687\/0869-866X-2019-27-si1-671-676","journal-title":"Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med"},{"key":"10275_CR93","first-page":"135","volume":"56","author":"P Iturralde","year":"1986","unstructured":"Iturralde, P., & Gil, M. (1986). Obstructive hypertrophic myocardiopathy and coronary atherosclerosis. Archivos del Instituto de Cardiologia de Mexico, 56, 135\u2013145.","journal-title":"Archivos del Instituto de Cardiologia de Mexico"},{"key":"10275_CR94","doi-asserted-by":"publisher","unstructured":"Marino, A., Zhang, Y., Rubinelli, L., Riemma, M. A., Ip, J. E., & Di Lorenzo, A. (2019). Pressure overload leads to coronary plaque formation, progression, and myocardial events in ApoE-\/- mice. JCI insight, 4, e128220. https:\/\/doi.org\/10.1172\/jci.insight.128220","DOI":"10.1172\/jci.insight.128220"},{"key":"10275_CR95","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/S0735-1097(00)00827-5","volume":"36","author":"M Satoh","year":"2000","unstructured":"Satoh, M., Nakamura, M., Satoh, H., Saitoh, H., Segawa, I., & Hiramori, K. (2000). Expression of tumor necrosis factor-alpha\u2013converting enzyme and tumor necrosis factor-alpha in human myocarditis. Journal of the American College of Cardiology, 36, 1288\u20131294.\u00a0https:\/\/doi.org\/10.1016\/s0735-1097(00)00827-5","journal-title":"Journal of the American College of Cardiology"},{"key":"10275_CR96","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1161\/CIRCULATIONAHA.105.571414","volume":"113","author":"PW Fedak","year":"2006","unstructured":"Fedak, P. W., Moravec, C. S., McCarthy, P. M., Altamentova, S. M., Wong, A. P., Skrtic, M., Verma, S., Weisel, R. D., & Li, R. K. (2006). Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy. Circulation, 113, 238\u2013245.\u00a0https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.571414","journal-title":"Circulation"},{"key":"10275_CR97","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.ejheart.2004.02.007","volume":"6","author":"M Satoh","year":"2004","unstructured":"Satoh, M., Iwasaka, J., Nakamura, M., Akatsu, T., Shimoda, Y., & Hiramori, K. (2004). Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure. European Journal of Heart Failure, 6, 869\u2013875.\u00a0https:\/\/doi.org\/10.1016\/j.ejheart.2004.02.007","journal-title":"European Journal of Heart Failure"},{"key":"10275_CR98","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/CIRCULATIONAHA.120.052384","volume":"144","author":"Y Luo","year":"2021","unstructured":"Luo, Y., Jiang, N., May, H. I., Luo, X., Ferdous, A., Schiattarella, G. G., Chen, G., Li, Q., Li, C., Rothermel, B. A., et al. (2021). Cooperative binding of ETS2 and NFAT links Erk1\/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy. Circulation, 144, 34\u201351.\u00a0https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.052384","journal-title":"Circulation"},{"key":"10275_CR99","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1080\/1354750X.2018.1458151","volume":"23","author":"AA Korotaeva","year":"2018","unstructured":"Korotaeva, A. A., Samoilova, E. V., Chepurnova, D. A., Zhitareva, I. V., Shuvalova, Y. A., & Prokazova, N. V. (2018). Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis. Biomarkers, 23, 527\u2013532.\u00a0https:\/\/doi.org\/10.1080\/1354750X.2018.1458151","journal-title":"Biomarkers"},{"key":"10275_CR100","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.bbrc.2020.01.008","volume":"523","author":"M Zhou","year":"2020","unstructured":"Zhou, M., Dai, W., Cui, Y., & Li, Y. (2020). Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor. Biochemical and Biophysical Research Communications, 523, 753\u2013758.\u00a0https:\/\/doi.org\/10.1016\/j.bbrc.2020.01.008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10275_CR101","doi-asserted-by":"publisher","first-page":"16186","DOI":"10.1074\/jbc.M116.718551","volume":"291","author":"J Wolf","year":"2016","unstructured":"Wolf, J., Waetzig, G. H., Chalaris, A., Reinheimer, T. M., Wege, H., Rose-John, S., & Garbers, C. (2016). Different soluble forms of the interleukin-6 family signal transducer gp130 fine-tune the blockade of interleukin-6 Trans-signaling. Journal of Biological Chemistry, 291, 16186\u201316196.\u00a0https:\/\/doi.org\/10.1074\/jbc.M116.718551","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR102","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00335001-0006-9","volume":"12","author":"MK Purcell","year":"2001","unstructured":"Purcell, M. K., Mu, J. L., Higgins, D. C., Elango, R., Whitmore, H., Harris, S., & Paigen, B. (2001). Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Mammalian Genome, 12, 495\u2013500.\u00a0https:\/\/doi.org\/10.1007\/s00335001-0006-9","journal-title":"Mammalian Genome"},{"key":"10275_CR103","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1074\/jbc.M510797200","volume":"281","author":"NL Tsakadze","year":"2006","unstructured":"Tsakadze, N. L., Sithu, S. D., Sen, U., English, W. R., Murphy, G., & D\u2019Souza, S. E. (2006). Tumor necrosis factor-alpha-converting enzyme (TACE\/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). Journal of Biological Chemistry, 281, 3157\u20133164.\u00a0https:\/\/doi.org\/10.1074\/jbc.M510797200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR104","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cardiores.2005.02.020","volume":"67","author":"RJ Singh","year":"2005","unstructured":"Singh, R. J., Mason, J. C., Lidington, E. A., Edwards, D. R., Nuttall, R. K., Khokha, R., Knauper, V., Murphy, G., & Gavrilovic, J. (2005). Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research, 67, 39\u201349.\u00a0https:\/\/doi.org\/10.1016\/j.cardiores.2005.02.020","journal-title":"Cardiovascular Research"},{"key":"10275_CR105","doi-asserted-by":"publisher","first-page":"37993","DOI":"10.1074\/jbc.M106434200","volume":"276","author":"KJ Garton","year":"2001","unstructured":"Garton, K. J., Gough, P. J., Blobel, C. P., Murphy, G., Greaves, D. R., Dempsey, P. J., & Raines, E. W. (2001). Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). Journal of Biological Chemistry, 276, 37993\u201338001.\u00a0https:\/\/doi.org\/10.1074\/jbc.M106434200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR106","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0021-9150(01)00587-1","volume":"160","author":"K Kitagawa","year":"2002","unstructured":"Kitagawa, K., Matsumoto, M., Sasaki, T., Hashimoto, H., Kuwabara, K., Ohtsuki, T., & Hori, M. (2002). Involvement of ICAM-1 in the progression of atherosclerosis in APOE-knockout mice. Atherosclerosis, 160, 305\u2013310.\u00a0https:\/\/doi.org\/10.1016\/s0021-9150(01)00587-1","journal-title":"Atherosclerosis"},{"key":"10275_CR107","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF02122744","volume":"165","author":"M Reinacher","year":"1978","unstructured":"Reinacher, M., M\u00fcller, H., Thiel, W., & Rudolph, R. L. (1978). Localization of papillomavirus and virus-specific antigens in the skin of tumor-bearing Mastomys natalensis (GRA Giessen). Medical Microbiology and Immunology, 165, 93\u201399.\u00a0https:\/\/doi.org\/10.1007\/BF02122744","journal-title":"Medical Microbiology and Immunology"},{"key":"10275_CR108","doi-asserted-by":"publisher","first-page":"17795","DOI":"10.1073\/pnas.0408096101","volume":"101","author":"D Teupser","year":"2004","unstructured":"Teupser, D., Pavlides, S., Tan, M., Gutierrez-Ramos, J. C., Kolbeck, R., & Breslow, J. L. (2004). Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A, 101, 17795\u201317800.\u00a0https:\/\/doi.org\/10.1073\/pnas.0408096101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10275_CR109","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1084\/jem.20092366","volume":"207","author":"A Chalaris","year":"2010","unstructured":"Chalaris, A., Adam, N., Sina, C., Rosenstiel, P., Lehmann-Koch, J., Schirmacher, P., Hartmann, D., Cichy, J., Gavrilova, O., Schreiber, S., et al. (2010). Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. Journal of Experimental Medicine, 207, 1617\u20131624.\u00a0https:\/\/doi.org\/10.1084\/jem.20092366","journal-title":"Journal of Experimental Medicine"},{"key":"10275_CR110","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/CIRCHEARTFAILURE.114.002029","volume":"8","author":"D Fan","year":"2015","unstructured":"Fan, D., Takawale, A., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., & Kassiri, Z. (2015). Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is essential in post-myocardial infarction repair by regulating angiogenesis. Circulation. Heart Failure, 8, 970\u2013979.\u00a0https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.114.002029","journal-title":"Circulation. Heart Failure"},{"key":"10275_CR111","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.bmc.2008.11.067","volume":"17","author":"S DasGupta","year":"2009","unstructured":"DasGupta, S., Murumkar, P. R., Giridhar, R., & Yadav, M. R. (2009). Current perspective of TACE inhibitors: A review. Bioorganic & Medicinal Chemistry, 17, 444\u2013459.\u00a0https:\/\/doi.org\/10.1016\/j.bmc.2008.11.067","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10275_CR112","doi-asserted-by":"publisher","first-page":"35598","DOI":"10.1038\/srep35598","volume":"6","author":"E Wong","year":"2016","unstructured":"Wong, E., Cohen, T., Romi, E., Levin, M., Peleg, Y., Arad, U., Yaron, A., Milla, M. E., & Sagi, I. (2016). Harnessing the natural inhibitory domain to control TNF\u03b1 converting enzyme (TACE) activity in vivo. Science and Reports, 6, 35598.\u00a0https:\/\/doi.org\/10.1038\/srep35598","journal-title":"Science and Reports"},{"key":"10275_CR113","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1161\/HYPERTENSIONAHA.116.07620","volume":"68","author":"T Takayanagi","year":"2016","unstructured":"Takayanagi, T., Forrester, S. J., Kawai, T., Obama, T., Tsuji, T., Elliott, K. J., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., et al. (2016). Vascular ADAM17 as a novel therapeutic target in mediating cardiovascular hypertrophy and perivascular fibrosis Induced by angiotensin II. Hypertension, 68, 949\u2013955.\u00a0https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.116.07620","journal-title":"Hypertension"},{"key":"10275_CR114","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/scibx.2014.246","volume":"7","author":"L Martz","year":"2014","unstructured":"Martz, L. (2014). Taking TIMP3 to heart. Science-Business eXchange, 7, 246\u2013246.\u00a0https:\/\/doi.org\/10.1038\/scibx.2014.246","journal-title":"Science-Business eXchange"},{"key":"10275_CR115","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/ncprheum0797","volume":"4","author":"ML Moss","year":"2008","unstructured":"Moss, M. L., Sklair-Tavron, L., & Nudelman, R. (2008). Drug insight: Tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nature Clinical Practice Rheumatology, 4, 300\u2013309.\u00a0https:\/\/doi.org\/10.1038\/ncprheum0797","journal-title":"Nature Clinical Practice Rheumatology"},{"key":"10275_CR116","first-page":"1014","volume":"7","author":"MM Thabet","year":"2006","unstructured":"Thabet, M. M., & Huizinga, T. W. (2006). Drug evaluation: Apratastat, a novel TACE\/MMP inhibitor for rheumatoid arthritis. Current Opinion in Investigational Drugs, 7, 1014\u20131019.","journal-title":"Current Opinion in Investigational Drugs"},{"key":"10275_CR117","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.4049\/jimmunol.179.5.2686","volume":"179","author":"K Horiuchi","year":"2007","unstructured":"Horiuchi, K., Kimura, T., Miyamoto, T., Takaishi, H., Okada, Y., Toyama, Y., & Blobel, C. P. (2007). Cutting edge: TNF-alpha-converting enzyme (TACE\/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. The Journal of Immunology, 179, 2686\u20132689.\u00a0https:\/\/doi.org\/10.4049\/jimmunol.179.5.2686","journal-title":"The Journal of Immunology"},{"key":"10275_CR118","doi-asserted-by":"publisher","first-page":"39716","DOI":"10.1074\/jbc.M507762200","volume":"280","author":"B Aktas","year":"2005","unstructured":"Aktas, B., Pozgajova, M., Bergmeier, W., Sunnarborg, S., Offermanns, S., Lee, D., Wagner, D. D., & Nieswandt, B. (2005). Aspirin induces platelet receptor shedding via ADAM17 (TACE). Journal of Biological Chemistry, 280, 39716\u201339722.\u00a0https:\/\/doi.org\/10.1074\/jbc.M507762200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR119","doi-asserted-by":"publisher","first-page":"38212","DOI":"10.1074\/jbc.M205142200","volume":"277","author":"MV G\u00f3mez-Gaviro","year":"2002","unstructured":"G\u00f3mez-Gaviro, M. V., Gonz\u00e1lez-Alvaro, I., Dom\u00ednguez-Jim\u00e9nez, C., Peschon, J., Black, R. A., S\u00e1nchez-Madrid, F., & D\u00edaz-Gonz\u00e1lez, F. (2002). Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. Journal of Biological Chemistry, 277, 38212\u201338221.\u00a0https:\/\/doi.org\/10.1074\/jbc.M205142200","journal-title":"Journal of Biological Chemistry"},{"key":"10275_CR120","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1681\/ASN.2004070573","volume":"16","author":"M Teng","year":"2005","unstructured":"Teng, M., Wolf, M., Ofsthun, M. N., Lazarus, J. M., Hern\u00e1n, M. A., Camargo, C. A., Jr., & Thadhani, R. (2005). Activated injectable vitamin D and hemodialysis survival: A historical cohort study. Journal of the American Society of Nephrology, 16, 1115\u20131125.\u00a0https:\/\/doi.org\/10.1681\/ASN.2004070573","journal-title":"Journal of the American Society of Nephrology"},{"key":"10275_CR121","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/ndt\/gfu311","volume":"30","author":"MV Arcidiacono","year":"2015","unstructured":"Arcidiacono, M. V., Yang, J., Fernandez, E., & Dusso, A. (2015). The induction of C\/EBP\u03b2 contributes to vitamin D inhibition of ADAM17 expression and parathyroid hyperplasia in kidney disease. Nephrology, Dialysis, Transplantation, 30, 423\u2013433.\u00a0https:\/\/doi.org\/10.1093\/ndt\/gfu311","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10275_CR122","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jsbmb.2010.03.064","volume":"121","author":"A Dusso","year":"2010","unstructured":"Dusso, A., Arcidiacono, M. V., Yang, J., & Tokumoto, M. (2010). Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality. Journal of Steroid Biochemistry and Molecular Biology, 121, 193\u2013198.\u00a0https:\/\/doi.org\/10.1016\/j.jsbmb.2010.03.064","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10275_CR123","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1007\/s00018-021-03779-w","volume":"78","author":"T Kawai","year":"2021","unstructured":"Kawai, T., Elliott, K. J., Scalia, R., & Eguchi, S. (2021). Contribution of ADAM17 and related ADAMs in cardiovascular diseases. Cellular and Molecular Life Sciences, 78, 4161\u20134187.\u00a0https:\/\/doi.org\/10.1007\/s00018-021-03779-w","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10275_CR124","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.bbrc.2017.06.153","volume":"490","author":"Y Cho","year":"2017","unstructured":"Cho, Y., Park, D., & Kim, C. (2017). Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding. Biochemical and Biophysical Research Communications, 490, 997\u20131003.\u00a0https:\/\/doi.org\/10.1016\/j.bbrc.2017.06.153","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10275_CR125","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3892\/ijo.2020.5045","volume":"57","author":"C Sun","year":"2020","unstructured":"Sun, C., Hu, A., Wang, S., Tian, B., Jiang, L., Liang, Y., Wang, H., & Dong, J. (2020). ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma. International Journal of Oncology, 57, 249\u2013263.\u00a0https:\/\/doi.org\/10.3892\/ijo.2020.5045","journal-title":"International Journal of Oncology"},{"key":"10275_CR126","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbrc.2013.02.022","volume":"432","author":"M Coglievina","year":"2013","unstructured":"Coglievina, M., Guarnaccia, C., Zlatev, V., Pongor, S., & Pintar, A. (2013). Jagged-1 juxtamembrane region: Biochemical characterization and cleavage by ADAM17 (TACE) catalytic domain. Biochemical and Biophysical Research Communications, 432, 666\u2013671.\u00a0https:\/\/doi.org\/10.1016\/j.bbrc.2013.02.022","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10275_CR127","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1002\/ijc.31615","volume":"143","author":"J Arai","year":"2018","unstructured":"Arai, J., Goto, K., Tanoue, Y., Ito, S., Muroyama, R., Matsubara, Y., Nakagawa, R., Kaise, Y., Lim, L. A., Yoshida, H., & Kato, N. (2018). Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells. International Journal of Cancer, 143, 2575\u20132583.\u00a0https:\/\/doi.org\/10.1002\/ijc.31615","journal-title":"International Journal of Cancer"},{"key":"10275_CR128","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.4049\/jimmunol.1601114","volume":"197","author":"H Kanzaki","year":"2016","unstructured":"Kanzaki, H., Makihira, S., Suzuki, M., Ishii, T., Movila, A., Hirschfeld, J., Mawardi, H., Lin, X., Han, X., Taubman, M. A., & Kawai, T. (2016). Soluble RANKL cleaved from activated lymphocytes by TNF-\u03b1-converting enzyme contributes to osteoclastogenesis in periodontitis. The Journal of Immunology, 197, 3871\u20133883.\u00a0https:\/\/doi.org\/10.4049\/jimmunol.1601114","journal-title":"The Journal of Immunology"},{"key":"10275_CR129","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1161\/CIRCRESAHA.116.310509","volume":"121","author":"J Xu","year":"2017","unstructured":"Xu, J., Sriramula, S., Xia, H., Moreno-Walton, L., Culicchia, F., Domenig, O., Poglitsch, M., & Lazartigues, E. (2017). Clinical relevance and role of neuronal AT(1) receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension. Circulation Research, 121, 43\u201355.\u00a0https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.310509","journal-title":"Circulation Research"},{"key":"10275_CR130","doi-asserted-by":"publisher","first-page":"32259","DOI":"10.1038\/srep32259","volume":"6","author":"H Kanzaki","year":"2016","unstructured":"Kanzaki, H., Shinohara, F., Suzuki, M., Wada, S., Miyamoto, Y., Yamaguchi, Y., Katsumata, Y., Makihira, S., Kawai, T., Taubman, M. A., & Nakamura, Y. (2016). A-Disintegrin and metalloproteinase (ADAM) 17 enzymatically degrades interferon-gamma. Science and Reports, 6, 32259.\u00a0https:\/\/doi.org\/10.1038\/srep32259","journal-title":"Science and Reports"},{"key":"10275_CR131","doi-asserted-by":"publisher","unstructured":"Parekh, R. U., & Sriramula, S. (2020). Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons. International Journal of Molecular Sciences, 22(1), 145. https:\/\/doi.org\/10.3390\/ijms22010145","DOI":"10.3390\/ijms22010145"},{"key":"10275_CR132","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00431-016-2696-8","volume":"175","author":"Q Peng","year":"2016","unstructured":"Peng, Q., Deng, Y., Yang, X., Leng, X., Yang, Y., & Liu, H. (2016). Genetic variants of ADAM17 are implicated in the pathological process of Kawasaki disease and secondary coronary artery lesions via the TGF-\u03b2\/SMAD3 signaling pathway. European Journal of Pediatrics, 175, 705\u2013713.\u00a0https:\/\/doi.org\/10.1007\/s00431-016-2696-8","journal-title":"European Journal of Pediatrics"},{"key":"10275_CR133","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1093\/rheumatology\/kew237","volume":"55","author":"MA Nielsen","year":"2016","unstructured":"Nielsen, M. A., Andersen, T., Etzerodt, A., Kragstrup, T. W., Rasmussen, T. K., Stengaard-Pedersen, K., Hetland, M. L., H\u00f8rslev-Petersen, K., Junker, P., \u00d8stergaard, M., et al. (2016). A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4\u20131BB activity and disease outcome in rheumatoid arthritis. Rheumatology (Oxford), 55, 1871\u20131879.\u00a0https:\/\/doi.org\/10.1093\/rheumatology\/kew237","journal-title":"Rheumatology (Oxford)"},{"key":"10275_CR134","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1038\/s41598-019-41811-z","volume":"9","author":"RN Mohammed","year":"2019","unstructured":"Mohammed, R. N., Wehenkel, S. C., Galkina, E. V., Yates, E. K., Preece, G., Newman, A., Watson, H. A., Ohme, J., Bridgeman, J. S., Durairaj, R. R. P., et al. (2019). ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Science and Reports, 9, 5487.\u00a0https:\/\/doi.org\/10.1038\/s41598-019-41811-z","journal-title":"Science and Reports"},{"key":"10275_CR135","doi-asserted-by":"publisher","first-page":"1744980","DOI":"10.1080\/2162402X.2020.1744980","volume":"9","author":"JJ Orme","year":"2020","unstructured":"Orme, J. J., Jazieh, K. A., Xie, T., Harrington, S., Liu, X., Ball, M., Madden, B., Charlesworth, M. C., Azam, T. U., Lucien, F., et al. (2020). ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. Oncoimmunology, 9, 1744980.\u00a0https:\/\/doi.org\/10.1080\/2162402X.2020.1744980","journal-title":"Oncoimmunology"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-022-10275-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-022-10275-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-022-10275-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T23:38:13Z","timestamp":1675726693000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-022-10275-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":135,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10275"],"URL":"https:\/\/doi.org\/10.1007\/s12265-022-10275-4","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"19 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No human and animal studies were carried out by the authors for this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}