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Trans. Res."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Chronic\u00a0ventricular\u00a0pacing can lead to\u00a0pacing-induced\u00a0cardiomyopathy (PICM). Clinical data alone is insufficient to predict who will develop PICM. Our study aimed to evaluate the circulating miR profile associated with chronic right ventricular pacing in children with congenital complete AV block (CCAVB) and to identify candidate miRs for longitudinal monitoring. Clinical data and blood were collected from chronically paced children (<jats:italic>N<\/jats:italic>\u2009=\u20099) and compared with non-paced controls (<jats:italic>N<\/jats:italic>\u2009=\u200913). miR microarrays from the buffy coat revealed 488\u00a0differentially regulated miRs between groups. Pathway analysis predicted both adaptive and maladaptive miR signaling associated with chronic pacing despite preserved ventricular function. Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced\u2009&gt;\u200910\u00a0years with the most dyregulation seen in a patient with sudden death vs. those paced\u2009&lt;\u200910\u00a0years. These miRs may help to identify early adverse remodeling in this population.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s12265-022-10318-w","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T14:22:08Z","timestamp":1663597328000},"page":"287-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block"],"prefix":"10.1007","volume":"16","author":[{"given":"Brittany M.","family":"Navarre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie L.","family":"Clouthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhuai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad S.","family":"Weldy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Dubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-8630","authenticated-orcid":false,"given":"Sushma","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"10318_CR1","first-page":"85","volume":"4","author":"M Micha\u00eblsson","year":"1972","unstructured":"Micha\u00eblsson M, Engle MA. 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