{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:11:42Z","timestamp":1780992702458,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200290"],"award-info":[{"award-number":["82200290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20220094"],"award-info":[{"award-number":["BX20220094"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. of Cardiovasc. Trans. Res."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functional tricuspid regurgitation (FTR) is the most common TR, although experimental models to effectively study it are scarce; therefore, this study aimed to establish a robust experimental swine model. A swine FTR model was developed using radiofrequency ablation, atrial septostomy, and right atrial volume overload. The baseline and follow-up echocardiography was performed to evaluate the progression FTR and changes in the heart. Autopsy was employed to verify the anatomy of tricuspid valve. One-month post intervention, among the subjects, one (8.3%) exhibited severe FTR, eight (66.7%) exhibited moderate TR, and three (25%) exhibited mild FTR. Each pig developed an atrial septal defect (diameter, 1.5\u2009\u00b1\u20090.5\u00a0cm). The tricuspid annular diameter significantly increased with enlargement of right heart (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No significant difference was found on left heart size and mitral regurgitation. We successfully developed a novel swine FTR model, providing a reliable and effective platform for further research on FTR.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>\n                <jats:p>The procedure to induce the FTR model on swines<\/jats:p>","DOI":"10.1007\/s12265-024-10510-0","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T14:02:06Z","timestamp":1715868126000},"page":"1004-1010","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation"],"prefix":"10.1007","volume":"17","author":[{"given":"Dawei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9814-3630","authenticated-orcid":false,"given":"Daxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"10510_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.21037\/cdt.2019.09.11","volume":"10","author":"D Kolte","year":"2020","unstructured":"Kolte D, Elmariah S. Current state of transcatheter tricuspid valve repair. Cardiovasc Diagn Ther. 2020;10:89\u201397.","journal-title":"Cardiovasc Diagn Ther"},{"key":"10510_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jjcc.2019.11.001","volume":"75","author":"C Izumi","year":"2020","unstructured":"Izumi C. Isolated functional tricuspid regurgitation: when should we go to surgical treatment? J Cardiol. 2020;75:339\u201343.","journal-title":"J Cardiol"},{"key":"10510_CR3","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/ehjci\/jeaa223","volume":"21","author":"D Muraru","year":"2020","unstructured":"Muraru D, Parati G, Badano LP. The tale of functional tricuspid regurgitation: when atrial fibrillation is the villain. 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