{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:14:06Z","timestamp":1787613246762,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute-phase inhibition of the pro-inflammatory alarmin S100A8\/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8\/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment significantly reduced S100A9 and increased neovascularization in the myocardium, assessed by CD31 staining. Proteomic analysis by mass-spectrometry showed strong myocardial upregulation of the pro-angiogenic proteins filamin A (~\u200910-fold) and reticulon 4 (~\u20095-fold), and downregulation of the anti-angiogenic proteins Ras homolog gene family member A (RhoA,\u2009~\u20094.7-fold), neutrophilic granule protein (Ngp,\u2009~\u20094.0-fold), and cathelicidin antimicrobial peptide (Camp,\u2009~\u20094.4-fold) versus controls. In-vitro, ABR-238901 protected against apoptosis induced by recombinant human S100A8\/A9 in human umbilical vein endothelial cells (HUVECs). In conclusion, S100A8\/A9 blockade promotes post-MI myocardial neovascularization by favorably modulating pro-angiogenic proteins in the myocardium and by inhibiting endothelial cell apoptosis.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s12265-024-10542-6","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T16:02:19Z","timestamp":1721059339000},"page":"1389-1399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Short-term S100A8\/A9 Blockade Promotes Cardiac Neovascularization after Myocardial Infarction"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-3502","authenticated-orcid":false,"given":"Razvan Gheorghita","family":"Mares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorel Iulian","family":"Suica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Uyy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca Maria","family":"Boteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita","family":"Ivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliu Gabriel","family":"Cocuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Horatiu","family":"Sabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan Adorjan","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu Simion","family":"Cotoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Elena","family":"Tomut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Simionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Antohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Schiopu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"10542_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","author":"SD Prabhu","year":"2016","unstructured":"Prabhu SD, Frangogiannis NG. The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res. 2016;119:91\u2013112.","journal-title":"Circ Res"},{"key":"10542_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-014-0444-7","volume":"109","author":"V Kain","year":"2014","unstructured":"Kain V, Prabhu SD, Halade GV. Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction. Basic Res Cardiol. 2014;109:1\u201317.","journal-title":"Basic Res Cardiol"},{"key":"10542_CR3","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1172\/JCI62423","volume":"122","author":"JK Chan","year":"2012","unstructured":"Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, Horwood N, Nanchahal J. Alarmins: awaiting a clinical response. J Clin Invest. 2012;122:2711\u20139.","journal-title":"J Clin Invest"},{"key":"10542_CR4","doi-asserted-by":"crossref","unstructured":"De Haan J, Smeets M, Pasterkamp G, Arslan F. Danger signals in the initiation of the inflammatory response after myocardial infarction. Mediators Inflamm. 2013;2013:206039.","DOI":"10.1155\/2013\/206039"},{"key":"10542_CR5","doi-asserted-by":"crossref","unstructured":"Schiopu A, Cotoi OS. S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease. Mediators Inflamm. 2013;2013:828354.","DOI":"10.1155\/2013\/828354"},{"key":"10542_CR6","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1093\/eurheartj\/ehm078","volume":"28","author":"LA Altwegg","year":"2007","unstructured":"Altwegg LA, Neidhart M, Hersberger M, M\u00fcller S, Eberli FR, Corti R, Roffi M, S\u00fctsch G, Gay S, von Eckardstein A. Myeloid-related protein 8\/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007;28:941\u20138.","journal-title":"Eur Heart J"},{"key":"10542_CR7","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","volume":"140","author":"Y Li","year":"2019","unstructured":"Li Y, Chen B, Yang X, et al. S100a8\/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic\/Reperfusion Injury. Circulation. 2019;140:751\u201364.","journal-title":"Circulation"},{"key":"10542_CR8","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1093\/eurheartj\/ehz461","volume":"40","author":"G Marinkovi\u0107","year":"2019","unstructured":"Marinkovi\u0107 G, Grauen Larsen H, Yndigegn T, et al. Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction. Eur Heart J. 2019;40:2713\u201323.","journal-title":"Eur Heart J"},{"key":"10542_CR9","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1089\/ars.2012.4849","volume":"18","author":"C Cochain","year":"2013","unstructured":"Cochain C, Channon KM, Silvestre J-S. Angiogenesis in the infarcted myocardium. Antioxid Redox Signal. 2013;18:1100\u201313.","journal-title":"Antioxid Redox Signal"},{"key":"10542_CR10","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1161\/01.CIR.0000128596.49339.05","volume":"109","author":"DW Losordo","year":"2004","unstructured":"Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies. Circulation. 2004;109:2692\u20137.","journal-title":"Circulation"},{"key":"10542_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-07524-x","volume":"7","author":"K Kobayashi","year":"2017","unstructured":"Kobayashi K, Maeda K, Takefuji M, Kikuchi R, Morishita Y, Hirashima M, Murohara T. Dynamics of angiogenesis in ischemic areas of the infarcted heart. Sci Rep. 2017;7:1\u201313.","journal-title":"Sci Rep"},{"key":"10542_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.47803\/rjc.2021.31.3.573","volume":"31","author":"RG Mares","year":"2021","unstructured":"Mares RG, Manu D, Szabo IA, Tomut ME, Pintican G, Cordos B, Jakobsson G, Dobreanu M, Cotoi OS, Schiopu A. Studying the innate immune response to myocardial infarction in a highly efficient experimental animal model. Romanian J Cardiol. 2021;31:573\u201385.","journal-title":"Romanian J Cardiol"},{"key":"10542_CR13","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","volume":"107","author":"E Gao","year":"2010","unstructured":"Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res. 2010;107:1445\u201353.","journal-title":"Circ Res"},{"key":"10542_CR14","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.3390\/ijms23095289","volume":"23","author":"RM Boteanu","year":"2022","unstructured":"Boteanu RM, Suica V-I, Uyy E, Ivan L, Cerveanu-Hogas A, Mares RG, Simionescu M, Schiopu A, Antohe F. Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery. Int J Mol Sci. 2022;23:5289.","journal-title":"Int J Mol Sci"},{"key":"10542_CR15","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","volume":"43","author":"S Frantz","year":"2022","unstructured":"Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J. 2022;43:2549\u201361.","journal-title":"Eur Heart J"},{"key":"10542_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1161\/ATVBAHA.113.302432","volume":"34","author":"OS Cotoi","year":"2014","unstructured":"Cotoi OS, Dun\u00e9r P, Ko N, Hedblad B, Nilsson J, Bj\u00f6rkbacka H, Schiopu A. Plasma S100A8\/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals. Arterioscler Thromb Vasc Biol. 2014;34:202\u201310.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10542_CR17","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1253\/circj.CJ-09-0564","volume":"74","author":"T Katashima","year":"2010","unstructured":"Katashima T, Naruko T, Terasaki F, Fujita M, Otsuka K, Murakami S, Sato A, Hiroe M, Ikura Y, Ueda M. Enhanced expression of the S100A8\/A9 complex in acute myocardial infarction patients. Circ J. 2010;74:741\u20138.","journal-title":"Circ J"},{"key":"10542_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","volume":"110","author":"Y Ma","year":"2016","unstructured":"Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY, Lindsey ML. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016;110:51\u201361.","journal-title":"Cardiovasc Res"},{"key":"10542_CR19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.47162\/RJME.64.2.04","volume":"64","author":"RG Mare\u015f","year":"2023","unstructured":"Mare\u015f RG, Sab\u0103u AH, Cocuz IG, Tomu\u0163 ME, Szabo IA, Sz\u0151ke AR, Tinca AC, Jakobsson G, Cotoi OS, \u015echiopu A. S100A8\u2215A9 is a valuable biomarker and treatment target to detect and modulate neutrophil involvement in myocardial infarction. Romanian J Morphol Embryol Rev Roum Morphol Embryol. 2023;64:151\u20138.","journal-title":"Romanian J Morphol Embryol Rev Roum Morphol Embryol"},{"key":"10542_CR20","doi-asserted-by":"publisher","first-page":"708770","DOI":"10.3389\/fimmu.2021.708770","volume":"12","author":"AC Mihaila","year":"2021","unstructured":"Mihaila AC, Ciortan L, Macarie RD, et al. Transcriptional Profiling and Functional Analysis of N1\/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation. Front Immunol. 2021;12:708770.","journal-title":"Front Immunol"},{"key":"10542_CR21","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/CIRCULATIONAHA.119.043833","volume":"141","author":"G Sreejit","year":"2020","unstructured":"Sreejit G, Abdel-Latif A, Athmanathan B, et al. Neutrophil-Derived S100A8\/A9 Amplify Granulopoiesis After Myocardial Infarction. Circulation. 2020;141:1080\u201394.","journal-title":"Circulation"},{"key":"10542_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1161\/CIRCULATIONAHA.121.056019","volume":"145","author":"G Sreejit","year":"2022","unstructured":"Sreejit G, Nooti SK, Jaggers RM, et al. Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction-Induced Granulopoiesis. Circulation. 2022;145:31\u201344.","journal-title":"Circulation"},{"key":"10542_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1161\/01.CIR.0000133316.92316.81","volume":"110","author":"A Abbate","year":"2004","unstructured":"Abbate A, Bonanno E, Mauriello A, Bussani R, Biondi-Zoccai GG, Liuzzo G, Leone AM, Silvestri F, Dobrina A, Baldi F. Widespread myocardial inflammation and infarct-related artery patency. Circulation. 2004;110:46\u201350.","journal-title":"Circulation"},{"key":"10542_CR24","first-page":"9","volume":"26","author":"RG Mares","year":"2018","unstructured":"Mares RG, Marinkovic G, Cotoi OS, Schiopu A. Innate Immune Mechanisms in Myocardial Infarction - An Update. Rev Romana Med Lab. 2018;26:9\u201320.","journal-title":"Rev Romana Med Lab"},{"key":"10542_CR25","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/jmri.27827","volume":"55","author":"M-X Yang","year":"2022","unstructured":"Yang M-X, Shi K, Xu H-Y, et al. Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping. J Magn Reson Imaging JMRI. 2022;55:555\u201364.","journal-title":"J Magn Reson Imaging JMRI"},{"key":"10542_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/cvr\/cvu226","volume":"105","author":"S Bandaru","year":"2015","unstructured":"Bandaru S, Gr\u00f6nros J, Redfors B, \u00c7il \u00c7, Pazooki D, Salimi R, Larsson E, Zhou A-X, \u00d6merovic E, Aky\u00fcrek LM. Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2015;105:151\u20139.","journal-title":"Cardiovasc Res"},{"key":"10542_CR27","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1089\/dna.2017.3813","volume":"36","author":"S-L Long","year":"2017","unstructured":"Long S-L, Li Y-K, Xie Y-J, Long Z-F, Shi J-F, Mo Z-C. Neurite Outgrowth Inhibitor B Receptor: A Versatile Receptor with Multiple Functions and Actions. DNA Cell Biol. 2017;36:1142\u201350.","journal-title":"DNA Cell Biol"},{"key":"10542_CR28","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41419-022-04754-4","volume":"13","author":"Y Zheng","year":"2022","unstructured":"Zheng Y, Lin J, Liu D, Wan G, Gu X, Ma J. Nogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling. Cell Death Dis. 2022;13:306.","journal-title":"Cell Death Dis"},{"key":"10542_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.biopha.2018.05.039","volume":"104","author":"J Li","year":"2018","unstructured":"Li J, Wu W, Xin Y, Zhao M, Liu X. Inhibition of Nogo-B promotes cardiac hypertrophy via endoplasmic reticulum stress. Biomed Pharmacother Biomedecine Pharmacother. 2018;104:193\u2013203.","journal-title":"Biomed Pharmacother Biomedecine Pharmacother"},{"key":"10542_CR30","doi-asserted-by":"publisher","first-page":"e025119","DOI":"10.1161\/JAHA.121.025119","volume":"11","author":"M Hauke","year":"2022","unstructured":"Hauke M, Eckenstaler R, Ripperger A, Ender A, Braun H, Benndorf RA. Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells. J Am Heart Assoc. 2022;11:e025119.","journal-title":"J Am Heart Assoc"},{"key":"10542_CR31","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1096\/fj.10-180604","volume":"25","author":"AM Boutt\u00e9","year":"2011","unstructured":"Boutt\u00e9 AM, Friedman DB, Bogyo M, Min Y, Yang L, Lin PC. Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis. FASEB J. 2011;25:2626\u201337.","journal-title":"FASEB J"},{"key":"10542_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.yjmcc.2019.12.011","volume":"139","author":"Y Wu","year":"2020","unstructured":"Wu Y, Zhang Y, Zhang J, Zhai T, Hu J, Luo H, Zhou H, Zhang Q, Zhou Z, Liu F. Cathelicidin aggravates myocardial ischemia\/reperfusion injury via activating TLR4 signaling and P2X7R\/NLRP3 inflammasome. J Mol Cell Cardiol. 2020;139:75\u201386.","journal-title":"J Mol Cell Cardiol"},{"key":"10542_CR33","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.gendis.2022.05.038","volume":"9","author":"Z Yan","year":"2022","unstructured":"Yan Z, Cheng X, Wang T, Hong X, Shao G, Fu C. Therapeutic potential for targeting Annexin A1 in fibrotic diseases. Genes Dis. 2022;9:1493\u2013505.","journal-title":"Genes Dis"},{"key":"10542_CR34","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1016\/j.jacc.2019.03.503","volume":"73","author":"B Ferraro","year":"2019","unstructured":"Ferraro B, Leoni G, Hinkel R, et al. Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. J Am Coll Cardiol. 2019;73:2990\u20133002.","journal-title":"J Am Coll Cardiol"},{"key":"10542_CR35","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1515\/hsz-2016-0166","volume":"397","author":"W Liu","year":"2016","unstructured":"Liu W, Hajjar KA. The annexin A2 system and angiogenesis. Biol Chem. 2016;397:1005\u201316.","journal-title":"Biol Chem"},{"key":"10542_CR36","doi-asserted-by":"publisher","first-page":"15546","DOI":"10.1073\/pnas.0607382103","volume":"103","author":"FB Engel","year":"2006","unstructured":"Engel FB, Hsieh PCH, Lee RT, Keating MT. FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A. 2006;103:15546\u201351.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10542_CR37","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1021\/acsbiomaterials.6b00509","volume":"3","author":"Z Wang","year":"2017","unstructured":"Wang Z, Long DW, Huang Y, Khor S, Li X, Jian X, Wang Y. Fibroblast Growth Factor-1 Released from a Heparin Coacervate Improves Cardiac Function in a Mouse Myocardial Infarction Model. ACS Biomater Sci Eng. 2017;3:1988\u201399.","journal-title":"ACS Biomater Sci Eng"},{"key":"10542_CR38","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1161\/CIRCULATIONAHA.117.029980","volume":"136","author":"MR Reboll","year":"2017","unstructured":"Reboll MR, Korf-Klingebiel M, Klede S, et al. EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation. 2017;136:1809\u201323.","journal-title":"Circulation"},{"key":"10542_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ydbio.2021.05.002","volume":"477","author":"Y Yoshida","year":"2021","unstructured":"Yoshida Y, Yamada A, Akimoto Y, et al. Cdc42 has important roles in postnatal angiogenesis and vasculature formation. Dev Biol. 2021;477:64\u20139.","journal-title":"Dev Biol"},{"key":"10542_CR40","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","volume":"127","author":"G Marinkovi\u0107","year":"2020","unstructured":"Marinkovi\u0107 G, Koenis DS, de Camp L, et al. S100A9 Links Inflammation and Repair in Myocardial Infarction. Circ Res. 2020;127:664\u201376.","journal-title":"Circ Res"},{"key":"10542_CR41","doi-asserted-by":"publisher","first-page":"D442","DOI":"10.1093\/nar\/gky1106","volume":"47","author":"Y Perez-Riverol","year":"2019","unstructured":"Perez-Riverol Y, Csordas A, Bai J, et al. The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res. 2019;47:D442\u201350.","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-024-10542-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-024-10542-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-024-10542-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T22:28:34Z","timestamp":1733956114000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-024-10542-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10542"],"URL":"https:\/\/doi.org\/10.1007\/s12265-024-10542-6","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"12 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. No human studies were carried out by the authors for this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}