{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:26:59Z","timestamp":1792168019005,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010441","name":"Medizinischen Fakult\u00e4t Heidelberg, Universit\u00e4t Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and cardiopulmonary bypass (CPB) on microcirculation. 40 Patients with severe aortic stenosis were enrolled. 20 patients underwent transapical\/transaxillary\/transaortic aortic valve replacement (TAVR), 20 underwent an open surgical approach with CPB (SAVR). HSI was used to determine tissue oxygenation (StO<jats:sub>2<\/jats:sub> and NIR), hemoglobin (THI) and water content (TWI) at the palm before\/after surgery (T1\/T2), and on the third postoperative day (T3). TAVR patients showed no significant changes of microcirculatory parameters during surgery. TWI significantly increased until T3. SAVR patients showed an increase of TWI and a decrease of THI, while StO<jats:sub>2<\/jats:sub> and NIR remained unchanged at T2. In SAVR patients, StO<jats:sub>2<\/jats:sub> and NIR correlated negatively with the duration of CPB and StO<jats:sub>2<\/jats:sub> correlated with intraoperative urine output at T2. HSI was able to detect microcirculatory changes during cardiac surgery. CPB duration seemed to affect tissue oxygenation. <\/jats:p>\n          <jats:p>Clinical trial registration: (German Clinical Trial Register): DRKS00024765.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s12265-024-10573-z","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T15:13:25Z","timestamp":1731078805000},"page":"295-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-038X","authenticated-orcid":false,"given":"Maximilian","family":"Dietrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aycan","family":"Tayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"H\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nusshag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Christine","family":"Kapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Studier-Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus Alexander","family":"Weigand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Karck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lichtenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawa","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"Suppl 10","key":"10573_CR1","doi-asserted-by":"publisher","first-page":"S1489","DOI":"10.21037\/jtd.2019.02.100","volume":"11","author":"JM Murkin","year":"2019","unstructured":"Murkin JM. Monitoring and optimization of the microcirculation during CPB. J Thorac Dis. 2019;11(Suppl 10):S1489\u201391.","journal-title":"J Thorac Dis"},{"issue":"5","key":"10573_CR2","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1016\/j.athoracsur.2009.07.002","volume":"88","author":"D De Backer","year":"2009","unstructured":"De Backer D, et al. Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia. Ann Thorac Surg. 2009;88(5):1396\u2013403.","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"10573_CR3","first-page":"455","volume":"86","author":"JC Sicsic","year":"1998","unstructured":"Sicsic JC, et al. Gastric mucosal oxygen delivery decreases during cardiopulmonary bypass despite constant systemic oxygen delivery. Anesth Analg. 1998;86(3):455\u201360.","journal-title":"Anesth Analg"},{"key":"10573_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mvr.2019.02.004","volume":"124","author":"Q Wu","year":"2019","unstructured":"Wu Q, et al. Correlation between acute degradation of the endothelial glycocalyx and microcirculation dysfunction during cardiopulmonary bypass in cardiac surgery. Microvasc Res. 2019;124:37\u201342.","journal-title":"Microvasc Res"},{"issue":"10","key":"10573_CR5","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.1111\/jocs.15805","volume":"36","author":"V Datt","year":"2021","unstructured":"Datt V, et al. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management. J Card Surg. 2021;36(10):3749\u201360.","journal-title":"J Card Surg"},{"issue":"2","key":"10573_CR6","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.bpa.2015.03.007","volume":"29","author":"WW Cui","year":"2015","unstructured":"Cui WW, Ramsay JG. Pharmacologic approaches to weaning from cardiopulmonary bypass and extracorporeal membrane oxygenation. Best Pract Res Clin Anaesthesiol. 2015;29(2):257\u201370.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"11","key":"10573_CR7","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1088\/0967-3334\/37\/11\/2064","volume":"37","author":"A Holmer","year":"2016","unstructured":"Holmer A, et al. Oxygenation and perfusion monitoring with a hyperspectral camera system for chemical based tissue analysis of skin and organs. Physiol Meas. 2016;37(11):2064\u201378.","journal-title":"Physiol Meas"},{"issue":"1","key":"10573_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13741-021-00211-6","volume":"10","author":"M Dietrich","year":"2021","unstructured":"Dietrich M, et al. Hyperspectral imaging for perioperative monitoring of microcirculatory tissue oxygenation and tissue water content in pancreatic surgery - an observational clinical pilot study. Perioper Med (Lond). 2021;10(1):42.","journal-title":"Perioper Med (Lond)"},{"key":"10573_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104164","volume":"136","author":"M Dietrich","year":"2021","unstructured":"Dietrich M, et al. Bedside hyperspectral imaging indicates a microcirculatory sepsis pattern - an observational study. Microvasc Res. 2021;136: 104164.","journal-title":"Microvasc Res"},{"issue":"12","key":"10573_CR10","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1158\/1078-0432.CCR-18-2089","volume":"25","author":"E Kho","year":"2019","unstructured":"Kho E, et al. Hyperspectral imaging for resection margin assessment during cancer surgery. Clin Cancer Res. 2019;25(12):3572\u201380.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10573_CR11","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/diagnostics12020507","volume":"12","author":"L Knospe","year":"2022","unstructured":"Knospe L, et al. New intraoperative imaging tools and image-guided surgery in gastric cancer surgery. Diagnostics (Basel). 2022;12(2):507.","journal-title":"Diagnostics (Basel)"},{"issue":"9596","key":"10573_CR12","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453\u20137.","journal-title":"Lancet"},{"issue":"4","key":"10573_CR13","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.bja.2018.12.019","volume":"122","author":"T Koponen","year":"2019","unstructured":"Koponen T, et al. Vasoactive-inotropic score and the prediction of morbidity and mortality after cardiac surgery. Br J Anaesth. 2019;122(4):428\u201336.","journal-title":"Br J Anaesth"},{"issue":"4","key":"10573_CR14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00246-012-0193-z","volume":"33","author":"RJ Butts","year":"2012","unstructured":"Butts RJ, et al. Comparison of maximum vasoactive inotropic score and low cardiac output syndrome as markers of early postoperative outcomes after neonatal cardiac surgery. Pediatr Cardiol. 2012;33(4):633\u20138.","journal-title":"Pediatr Cardiol"},{"issue":"12","key":"10573_CR15","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.3390\/jcm8122208","volume":"8","author":"C Ortega-Loubon","year":"2019","unstructured":"Ortega-Loubon C, et al. Near-infrared spectroscopy monitoring in cardiac and noncardiac surgery: pairwise and network meta-analyses. J Clin Med. 2019;8(12):2208.","journal-title":"J Clin Med"},{"issue":"3","key":"10573_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1177\/021849230401200303","volume":"12","author":"Y Hamada","year":"2004","unstructured":"Hamada Y, et al. Capillary leakage in cardiac surgery with cardiopulmonary bypass. Asian Cardiovasc Thorac Ann. 2004;12(3):193\u20137.","journal-title":"Asian Cardiovasc Thorac Ann"},{"issue":"12","key":"10573_CR17","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.3390\/biomedicines9121829","volume":"9","author":"M Dietrich","year":"2021","unstructured":"Dietrich M, et al. Hyperspectral imaging for the evaluation of microcirculatory tissue oxygenation and perfusion quality in haemorrhagic shock: a porcine study. Biomedicines. 2021;9(12):1829.","journal-title":"Biomedicines"},{"issue":"3","key":"10573_CR18","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00784-020-03382-6","volume":"25","author":"DGE Thiem","year":"2021","unstructured":"Thiem DGE, et al. Hyperspectral analysis for perioperative perfusion monitoring-a clinical feasibility study on free and pedicled flaps. Clin Oral Investig. 2021;25(3):933\u201345.","journal-title":"Clin Oral Investig"},{"key":"10573_CR19","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/cc8000","volume":"13","author":"D Myers","year":"2009","unstructured":"Myers D, et al. Tissue hemoglobin index: a non-invasive optical measure of total tissue hemoglobin. Crit Care. 2009;13:S2.","journal-title":"Crit Care"},{"issue":"5","key":"10573_CR20","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/anae.14577","volume":"74","author":"NAM Dekker","year":"2019","unstructured":"Dekker NAM, et al. Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass. Anaesthesia. 2019;74(5):609\u201318.","journal-title":"Anaesthesia"},{"issue":"10","key":"10573_CR21","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.3390\/bioengineering10101167","volume":"10","author":"H Kuhlmann","year":"2023","unstructured":"Kuhlmann H, et al. Bedside hyperspectral imaging and organ dysfunction severity in critically Ill COVID-19 patients-a prospective, monocentric observational study. Bioengineering (Basel). 2023;10(10):1167.","journal-title":"Bioengineering (Basel)"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-024-10573-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-024-10573-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-024-10573-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T08:44:11Z","timestamp":1746521051000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-024-10573-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10573"],"URL":"https:\/\/doi.org\/10.1007\/s12265-024-10573-z","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"21 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been performed in conformance with the ethical standards of the Declaration of Helsinki and its later amendments. Ethical approval for this study (reference number S-128\/2021) was provided by the Ethical Committee of the Medical Faculty of Heidelberg University, Alte Glockengie\u00dferei 11\/1, 69,115 Heidelberg, Germany (Chairperson Prof. Dr. med. Dr. h.c. Thomas Strowitzki) on 04 March 2021. Informed consent was obtained from all patients for being included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Subjects\/Informed Consent Statement"}},{"value":"The authors declare no conflict of interest. This study was supported by Diaspective Vision through the provision of the TIVITA\u00ae Tissue System. Diaspective Vision had no role in the design, execution, interpretation, or writing of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}