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Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin\/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62\u2009\u00b1\u20091.54 mm<jats:sup>2<\/jats:sup> at baseline to 2.12\u2009\u00b1\u20090.92 mm<jats:sup>2<\/jats:sup> at follow-up in the Magmaris group, from 6.99\u2009\u00b1\u20091.49 mm<jats:sup>2<\/jats:sup> to 3.07\u2009\u00b1\u20091.52 mm<jats:sup>2<\/jats:sup> in the Absorb group, and from 6.05\u2009\u00b1\u20091.11 mm<jats:sup>2<\/jats:sup> to 2.65\u2009\u00b1\u20090.93 mm<jats:sup>2<\/jats:sup> in the Desolve group. Histologic examination revealed advanced human-like stenosis. BRS implantation in hypercholesterolemic PCSK9 minipigs induced human-like stenoses and may serve as a feasible preclinical model for obstructive coronary artery disease.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s12265-025-10607-0","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T11:11:37Z","timestamp":1743160297000},"page":"544-555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-2330","authenticated-orcid":false,"given":"Jacob","family":"Nicolaisen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Fr\u00f8sig Bo","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M\u00e6ng","family":"Bj\u00f8rklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Nors","family":"Skov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiken Kudahl","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Thim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouke","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Fog","family":"Bentzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Ramsing","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"10607_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"P Libby","year":"2019","unstructured":"Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. 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The study is reported as per the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical"}},{"value":"Clinical trial registration number: Not applicable.The present study was approved by the Danish Animal Experiments Inspectorate (2015\u201315-0201\u201300570). All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. No human studies were carried out by the authors for this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study Registration"}},{"value":"No human studies were carried out by the authors for this article. All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Studies"}},{"value":"EHC has received institutional research grants from Abbott and Biotronik and speaker fees from Abbott. NRH received institutional research grants and speaker fees from Abbott.All other authors have no conflicts of interests to declare.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}