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Forward flow parameters were compromised prior to pressure-parameters. Diastolic function was impaired and mitochondrial damage was observed. CS rapidly impairs LV hemodynamic and mitochondrial function, highlighting the importance of monitoring forward flow and targeting mitochondrial function in treatment.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s12265-025-10647-6","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:26:47Z","timestamp":1750771607000},"page":"1204-1217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-3768","authenticated-orcid":false,"given":"Oskar Kj\u00e6rgaard","family":"H\u00f8rsdal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-7980","authenticated-orcid":false,"given":"Peter Hartmund","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-8758","authenticated-orcid":false,"given":"Ole Kristian Lerche","family":"Helgestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-5195","authenticated-orcid":false,"given":"Hanne Berg","family":"Ravn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5845","authenticated-orcid":false,"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9753-4142","authenticated-orcid":false,"given":"Henrik","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-3869","authenticated-orcid":false,"given":"Roni Rangh\u00f8j","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6363-7406","authenticated-orcid":false,"given":"Nigopan","family":"Gopalasingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-0656","authenticated-orcid":false,"given":"Kristoffer","family":"Berg-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"10647_CR1","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMra1606915","volume":"376","author":"JL Anderson","year":"2017","unstructured":"Anderson JL, Morrow DA. 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The treatment and ethical oversight of the animals strictly followed established welfare protocols and regulatory standards as mandated by both Danish and European legislation. All methodologies and animal handling procedures were in full compliance with the EU Directive 2010\/63\/EU on the protection of animals used for scientific purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Henrik Wiggers has been the principal or a sub-investigator in studies involving the following pharmaceutical companies: Merck, Pfizer Ltd., Bayer Healthcare AG, Astra Zeneca A\/S, Sanofi Aventis, MSD Denmark, Novartis Healthcare A\/S, Boehringer Ingelheim, Amgen, Merck Sharp & Dohme Ltd., Novo Nordisk, Eli Lilly. The remaining authors declare no conflict of interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}