{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:12:19Z","timestamp":1780063939402,"version":"3.54.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL159089"],"award-info":[{"award-number":["R01HL159089"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL139785"],"award-info":[{"award-number":["R01HL139785"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["938033"],"award-info":[{"award-number":["938033"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12265-025-10654-7","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T18:03:22Z","timestamp":1753121002000},"page":"1185-1191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normoxemic Extracorporeal Membrane Oxygenation Reduces Infarct Size and Preserves Mitochondrial Integrity in Preclinical Models of Acute Myocardial Infarction"],"prefix":"10.1007","volume":"18","author":[{"given":"Shreyas","family":"Bhave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lija","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Reyelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejasvi","family":"Aryaputra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Everett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arik","family":"Stolyaranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-6796","authenticated-orcid":false,"given":"Navin K.","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"issue":"12","key":"10654_CR1","doi-asserted-by":"publisher","first-page":"e005929","DOI":"10.1161\/CIRCHEARTFAILURE.119.005929","volume":"12","author":"S Vallabhajosyula","year":"2019","unstructured":"Vallabhajosyula S, Prasad A, Bell MR, Sandhu GS, Eleid MF, Dunlay SM, et al. Extracorporeal membrane oxygenation use in acute myocardial infarction in the United States, 2000 to 2014. Circ Heart Fail. 2019;12(12):e005929.","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10654_CR2","first-page":"e15219","volume":"13","author":"S Rao","year":"2021","unstructured":"Rao S, Khan A, Aiello D. Myocardial infarction in a patient with hereditary hemorrhagic telangiectasia: a case report and review of literature. Cureus. 2021;13(5):e15219.","journal-title":"Cureus"},{"issue":"5","key":"10654_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jacc.2018.05.038","volume":"72","author":"N Uriel","year":"2018","unstructured":"Uriel N, Sayer G, Annamalai S, Kapur NK, Burkhoff D. Mechanical unloading in heart failure. J Am Coll Cardiol. 2018;72(5):569\u201380.","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"10654_CR4","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.118.036691","volume":"138","author":"PM Becher","year":"2018","unstructured":"Becher PM, Schrage B, Sinning CR, Schmack B, Fluschnik N, Schwarzl M, et al. Venoarterial extracorporeal membrane oxygenation for cardiopulmonary support. Circulation. 2018;138(20):2298\u2013300.","journal-title":"Circulation"},{"issue":"17","key":"10654_CR5","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1161\/CIRCULATIONAHA.123.065298","volume":"149","author":"L Swain","year":"2024","unstructured":"Swain L, Bhave S, Qiao X, Reyelt L, Everett KD, Awata J, et al. Novel role for cardiolipin as a target of therapy to mitigate myocardial injury caused by venoarterial extracorporeal membrane oxygenation. Circulation. 2024;149(17):1341\u201353.","journal-title":"Circulation"},{"issue":"3","key":"10654_CR6","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0267659112473172","volume":"28","author":"RA Hayes","year":"2013","unstructured":"Hayes RA, Shekar K, Fraser JF. Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem. Perfusion. 2013;28(3):184\u201393.","journal-title":"Perfusion"},{"issue":"4","key":"10654_CR7","doi-asserted-by":"publisher","first-page":"e010328","DOI":"10.1161\/CIRCHEARTFAILURE.122.010328","volume":"16","author":"JC Jentzer","year":"2023","unstructured":"Jentzer JC, Miller PE, Alviar C, Yalamuri S, Bohman JK, Tonna JE. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock. Circ Heart Fail. 2023;16(4):e010328.","journal-title":"Circ Heart Fail"},{"issue":"6","key":"10654_CR8","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.jacc.2020.06.031","volume":"76","author":"L Swain","year":"2020","unstructured":"Swain L, Reyelt L, Bhave S, Qiao X, Thomas CJ, Zweck E, et al. Transvalvular ventricular unloading before reperfusion in acute myocardial infarction. J Am Coll Cardiol. 2020;76(6):684\u201399.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10654_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12265-021-10114-y","volume":"15","author":"X Qiao","year":"2022","unstructured":"Qiao X, Bhave S, Swain L, Zweck E, Reyelt L, Crowley P, et al. Myocardial injury promotes matrix metalloproteinase-9 activity in the renal cortex in preclinical models of acute myocardial infarction. J Cardiovasc Transl Res. 2022;15(2):207\u201316.","journal-title":"J Cardiovasc Transl Res"},{"issue":"6","key":"10654_CR10","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/ejcts\/ezt637","volume":"46","author":"CI McDonald","year":"2014","unstructured":"McDonald CI, Fraser JF, Coombes JS, Fung YL. Oxidative stress during extracorporeal circulation. Eur J Cardiothorac Surg. 2014;46(6):937\u201343.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"10654_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13054-022-04133-7","volume":"26","author":"MD Moussa","year":"2022","unstructured":"Moussa MD, Beyls C, Lamer A, Roksic S, Juthier F, Leroy G, et al. Early hyperoxia and 28-day mortality in patients on venoarterial ECMO support for refractory cardiogenic shock: a bicenter retrospective propensity score-weighted analysis. Crit Care. 2022;26(1):257.","journal-title":"Crit Care"},{"issue":"2","key":"10654_CR12","first-page":"153","volume":"4","author":"K Waxman","year":"1996","unstructured":"Waxman K. Shock: ischemia, reperfusion, and inflammation. New Horiz. 1996;4(2):153\u201360.","journal-title":"New Horiz"},{"issue":"6","key":"10654_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s00068-007-7152-z","volume":"33","author":"B Dorweiler","year":"2007","unstructured":"Dorweiler B, Pruefer D, Andrasi TB, Maksan SM, Schmiedt W, Neufang A, et al. Ischemia-reperfusion injury\u202f: pathophysiology and clinical implications. Eur J Trauma Emerg Surg. 2007;33(6):600\u201312.","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"2","key":"10654_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","volume":"23","author":"ET Chouchani","year":"2016","unstructured":"Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, et al. A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury. Cell Metab. 2016;23(2):254\u201363.","journal-title":"Cell Metab"},{"issue":"3","key":"10654_CR15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.pharmthera.2013.07.005","volume":"140","author":"DA Brown","year":"2013","unstructured":"Brown DA, Sabbah HN, Shaikh SR. Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia\/reperfusion injury. Pharmacol Ther. 2013;140(3):258\u201366.","journal-title":"Pharmacol Ther"},{"issue":"7","key":"10654_CR16","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jacbts.2023.01.004","volume":"8","author":"KD Everett","year":"2023","unstructured":"Everett KD, Swain L, Reyelt L, Majumdar M, Qiao X, Bhave S, et al. Transvalvular unloading mitigates ventricular injury due to venoarterial extracorporeal membrane oxygenation in acute myocardial infarction. JACC Basic Transl Sci. 2023;8(7):769\u201380.","journal-title":"JACC Basic Transl Sci"},{"issue":"5","key":"10654_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11940-021-00671-7","volume":"23","author":"B Illum","year":"2021","unstructured":"Illum B, Odish M, Minokadeh A, Yi C, Owens RL, Pollema T, et al. Evaluation, treatment, and impact of neurologic injury in adult patients on extracorporeal membrane oxygenation: a review. Curr Treat Options Neurol. 2021;23(5):15.","journal-title":"Curr Treat Options Neurol"},{"issue":"5","key":"10654_CR18","doi-asserted-by":"publisher","first-page":"e004337","DOI":"10.1161\/CIRCINTERVENTIONS.116.004337","volume":"10","author":"A Mandawat","year":"2017","unstructured":"Mandawat A, Rao SV. Percutaneous mechanical circulatory support devices in cardiogenic shock. Circ Cardiovasc Interv. 2017;10(5):e004337.","journal-title":"Circ Cardiovasc Interv"},{"issue":"170","key":"10654_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.resuscitation.2021.10.007","volume":"1","author":"L Hobohm","year":"2022","unstructured":"Hobohm L, Sagoschen I, Habertheuer A, Barco S, Valerio L, Wild J, et al. Clinical use and outcome of extracorporeal membrane oxygenation in patients with pulmonary embolism. Resuscitation. 2022;1(170):285\u201392.","journal-title":"Resuscitation"},{"issue":"9","key":"10654_CR20","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/s00134-024-07564-8","volume":"50","author":"A Burrell","year":"2024","unstructured":"Burrell A, Bailey MJ, Bellomo R, Buscher H, Eastwood G, Forrest P, et al. Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation. Intensive Care Med. 2024;50(9):1470\u201383.","journal-title":"Intensive Care Med"},{"issue":"5","key":"10654_CR21","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jacc.2018.05.034","volume":"72","author":"ML Esposito","year":"2018","unstructured":"Esposito ML, Zhang Y, Qiao X, Reyelt L, Paruchuri V, Schnitzler GR, et al. Left ventricular unloading before reperfusion promotes functional recovery after acute myocardial infarction. J Am Coll Cardiol. 2018;72(5):501\u201314.","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10654-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-025-10654-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10654-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:49:52Z","timestamp":1780062592000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-025-10654-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10654"],"URL":"https:\/\/doi.org\/10.1007\/s12265-025-10654-7","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"24 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal study protocols were approved by the Institutional Animal Care and Use Committee at Tufts Medical Center.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"No human studies were carried out by the authors for this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"No human studies were carried out by the authors for this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Dr. Kapur receives institutional research support and consulting\/speaking honoraria from Abbott, Abiomed, Boston Scientific, Medtronic, Getinge, LivaNova, Edwards, and Zoll. No other authors have relevant disclosures.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"S.B., L.S., L.R., X.Q., K.E., T.A., K.J., I.B., A.S., E.M., M.C. have no competing interests to declare. N.K.K. receives institutional grant support and speaker\/consulting honoraria from: Abbott, Abiomed, Boston Scientific, LivaNova, Medtronic, MD Start, and Precardia.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}