{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:58:08Z","timestamp":1786985888042,"version":"build-2736575974"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key R&D Program of China Grant","award":["2022YFA1104500"],"award-info":[{"award-number":["2022YFA1104500"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108002"],"award-info":[{"award-number":["82020108002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82225005"],"award-info":[{"award-number":["82225005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23410750100"],"award-info":[{"award-number":["23410750100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12265-025-10660-9","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T14:28:15Z","timestamp":1753280895000},"page":"1113-1131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nanoparticles For Rescue: Innovative Therapeutic Strategy For Cardiac Repair After Myocardial Infarction"],"prefix":"10.1007","volume":"18","author":[{"given":"Yi-an","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjia","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeli","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-0003","authenticated-orcid":false,"given":"Junjie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"issue":"10065","key":"10660_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","volume":"389","author":"GW Reed","year":"2017","unstructured":"Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet (London, England). 2017;389(10065):197\u2013210. https:\/\/doi.org\/10.1016\/S0140-6736(16)30677-8.","journal-title":"Lancet (London, England)."},{"issue":"6","key":"10660_CR2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jshs.2024.05.012","volume":"13","author":"CJ Lavie","year":"2024","unstructured":"Lavie CJ, Carbone S, Slipczuk L. Physical activity with or without dietary intervention for the prevention of cardiovascular diseases. J Sport Health Sci. 2024;13(6):753\u20135. https:\/\/doi.org\/10.1016\/j.jshs.2024.05.012.","journal-title":"J Sport Health Sci."},{"issue":"1","key":"10660_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41401-018-0060-4","volume":"40","author":"WB Fu","year":"2019","unstructured":"Fu WB, Wang WE, Zeng CY. Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors. Acta Pharmacol Sin. 2019;40(1):9\u201312. https:\/\/doi.org\/10.1038\/s41401-018-0060-4.","journal-title":"Acta Pharmacol Sin."},{"issue":"4","key":"10660_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.tcm.2012.09.010","volume":"23","author":"EP Daskalopoulos","year":"2013","unstructured":"Daskalopoulos EP, Hermans KCM, Janssen BJA, Matthijs BW. Targeting the Wnt\/frizzled signaling pathway after myocardial infarction: a new tool in the therapeutic toolbox? Trends Cardiovasc Med. 2013;23(4):121\u20137. https:\/\/doi.org\/10.1016\/j.tcm.2012.09.010.","journal-title":"Trends Cardiovasc Med."},{"issue":"7675","key":"10660_CR5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature24045","volume":"550","author":"JP Leach","year":"2017","unstructured":"Leach JP, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill MC, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550(7675):260\u20134. https:\/\/doi.org\/10.1038\/nature24045.","journal-title":"Nature."},{"issue":"2","key":"10660_CR6","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ymthe.2023.12.013","volume":"32","author":"YY Qin","year":"2024","unstructured":"Qin YY, Huang XR, Zhang J, Wu W, Chen J, Wan S, et al. Neuropeptide Y attenuates cardiac remodeling and deterioration of function following myocardial infarction. Molecular Ther J American Soc. Gene Ther. 2024;32(2):559\u201361. https:\/\/doi.org\/10.1016\/j.ymthe.2023.12.013.","journal-title":"Gene Ther."},{"key":"10660_CR7","doi-asserted-by":"publisher","unstructured":"Rao SV, O\u2019Donoghue ML, Ruel M, Rab,T, Tamis-Holland JE, Alexander JH, \u2026 Williams MS. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: A report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2025;151(13): e771\u2013e862. https:\/\/doi.org\/10.1161\/CIR.0000000000001309","DOI":"10.1161\/CIR.0000000000001309"},{"issue":"11","key":"10660_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/clc.22031","volume":"35","author":"J Grinstein","year":"2012","unstructured":"Grinstein J, Cannon CP. Aspirin resistance: current status and role of tailored therapy. Clin Cardiol. 2012;35(11):673\u201381. https:\/\/doi.org\/10.1002\/clc.22031.","journal-title":"Clin Cardiol."},{"key":"10660_CR9","doi-asserted-by":"publisher","unstructured":"Elsayed OR, Wakeel LME, Saleh MA, Ahmed MA. The impact of alpha lipoic acid administration on oxidative stress markers and occurrence of no-reflow phenomenon in post myocardial infarction patients. Future J Pharm Sci. 2025;11(1):1\u201313. https:\/\/doi.org\/10.1186\/s43094-025-00805-7","DOI":"10.1186\/s43094-025-00805-7"},{"key":"10660_CR10","doi-asserted-by":"publisher","unstructured":"Chen X, Li X, Sun J, Lin Y, Li Y, Lv X, \u2026 Jia X. Mongolian medicine Eerdun-Wurile promotes myocardial regeneration by regulating MVDA in zebrafish. Cell Regeneration . 2025;14(1): 22. https:\/\/doi.org\/10.1186\/s13619-025-00235-z","DOI":"10.1186\/s13619-025-00235-z"},{"issue":"1","key":"10660_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40779-025-00610-6","volume":"12","author":"KJ Chen","year":"2025","unstructured":"Chen KJ, Zhang Y, Zhu XY, Yu S, Xie Y, Jin CJ, et al. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis. Military Med Res. 2025;12(1):26. https:\/\/doi.org\/10.1186\/s40779-025-00610-6.","journal-title":"Military Med Res."},{"key":"10660_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117047","volume":"239","author":"D Wang","year":"2025","unstructured":"Wang D, Li L, Zhang F, Liu Q, Wang WL, Wang ZX, et al. SLC1A5 mediates myocardial damage after myocardial infarction by triggering cardiomyocyte ferroptosis. Biochem Pharmacol. 2025;239:117047. https:\/\/doi.org\/10.1016\/j.bcp.2025.117047.","journal-title":"Biochem Pharmacol."},{"issue":"1","key":"10660_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41591-024-03434-4","volume":"31","author":"K Zhang","year":"2025","unstructured":"Zhang K, Yang X, Wang Y, Yu Y, Huang N, Li G, et al. Artificial intelligence in drug development. Nature Medicine. 2025;31(1):45\u201359. https:\/\/doi.org\/10.1038\/s41591-024-03434-4.","journal-title":"Nature Medicine."},{"issue":"12","key":"10660_CR14","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/sctm.18-0120","volume":"7","author":"MM Lalu","year":"2018","unstructured":"Lalu MM, Mazzarello S, Zlepnig J, Dong YYR, Montroy J, McIntyre L, et al. Safety and efficacy of adult stem cell therapy for acute myocardial infarction and ischemic heart failure (SafeCell Heart): A systematic review and meta-analysis. Stem Cells Translational Med. 2018;7(12):857\u201366. https:\/\/doi.org\/10.1002\/sctm.18-0120.","journal-title":"Stem Cells Translational Med."},{"issue":"7","key":"10660_CR15","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1021\/acs.nanolett.6b02093","volume":"16","author":"DJ Richards","year":"2016","unstructured":"Richards DJ, Tan Y, Coyle R, Li Y, Xu R, Yeung N, et al. Nanowires and electrical stimulation synergistically improve functions of hiPSC cardiac spheroids. Nano Lett. 2016;16(7):4670\u20138. https:\/\/doi.org\/10.1021\/acs.nanolett.6b02093.","journal-title":"Nano Lett."},{"key":"10660_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jconrel.2019.01.009","volume":"295","author":"F Mottaghitalab","year":"2019","unstructured":"Mottaghitalab F, Farokhi M, Fatahi Y, Atyabi F, Dinarvand R. New insights into designing hybrid nanoparticles for lung cancer: Diagnosis and treatment. J Control Release. 2019;295:250\u201367. https:\/\/doi.org\/10.1016\/j.jconrel.2019.01.009.","journal-title":"J Control Release."},{"issue":"3","key":"10660_CR17","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.jconrel.2013.09.013","volume":"172","author":"MJ Ernsting","year":"2013","unstructured":"Ernsting MJ, Murakami M, Roy A, Li SD. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release. 2013;172(3):782\u201394. https:\/\/doi.org\/10.1016\/j.jconrel.2013.09.013.","journal-title":"J Control Release."},{"issue":"28","key":"10660_CR18","doi-asserted-by":"publisher","first-page":"30737","DOI":"10.1021\/acsomega.4c03252","volume":"9","author":"GK Hasabnis","year":"2024","unstructured":"Hasabnis GK, Altintas Z. Cardiac Troponin I-responsive nanocomposite materials for voltammetric monitoring of acute myocardial infarction. ACS Omega. 2024;9(28):30737\u201350. https:\/\/doi.org\/10.1021\/acsomega.4c03252.","journal-title":"ACS Omega."},{"key":"10660_CR19","doi-asserted-by":"publisher","first-page":"e2209497","DOI":"10.1002\/adma.202209497","volume-title":"Adv Mater","author":"J Zhang","year":"2023","unstructured":"Zhang J, Shen S, Lin R, Huang J, Pu C, Chen P, \u2026 Hou H. Highly stretchable and biocompatible wrinkled nanoclay-composite hydrogel with enhanced sensing capability for precise detection of myocardial infarction. Adv Mater . 2023;35(9): e2209497. https:\/\/doi.org\/10.1002\/adma.202209497."},{"issue":"3","key":"10660_CR20","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1021\/acsnano.1c08890","volume":"16","author":"M Mu\u00f1oz","year":"2022","unstructured":"Mu\u00f1oz M, Eren Cimenci C, Goel K, Comtois-Bona M, Hossain M, McTiernan C, et al. Nanoengineered sprayable therapy for treating myocardial infarction. ACS Nano. 2022;16(3):3522\u201337. https:\/\/doi.org\/10.1021\/acsnano.1c08890.","journal-title":"ACS Nano."},{"issue":"13","key":"10660_CR21","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2169\/internalmedicine.45.1765","volume":"45","author":"H Tsutsui","year":"2006","unstructured":"Tsutsui H. Mitochondrial oxidative stress and heart failure. Internal Medicine (Tokyo, Japan). 2006;45(13):809\u201313. https:\/\/doi.org\/10.2169\/internalmedicine.45.1765.","journal-title":"Internal Medicine (Tokyo, Japan)."},{"issue":"8","key":"10660_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1089\/ars.2014.5887","volume":"22","author":"T Yao","year":"2015","unstructured":"Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, et al. Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal. 2015;22(8):633\u201350. https:\/\/doi.org\/10.1089\/ars.2014.5887.","journal-title":"Antioxid Redox Signal."},{"key":"10660_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13098-019-0485-z","volume":"12","author":"L Xiang","year":"2020","unstructured":"Xiang L, Zhang Q, Chi C, Wu G, Lin Z, Li J, et al. Curcumin analog A13 alleviates oxidative stress by activating Nrf2\/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats. Diabetol Metab Syndr. 2020;12:1. https:\/\/doi.org\/10.1186\/s13098-019-0485-z.","journal-title":"Diabetol Metab Syndr."},{"key":"10660_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174403","volume":"909","author":"K Fan","year":"2021","unstructured":"Fan K, Huang W, Qi H, Song C, He C, Liu Y, et al. The Egr-1\/miR-15a-5p\/GPX4 axis regulates ferroptosis in acute myocardial infarction. European. J Pharmacol. 2021;909:174403. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174403.","journal-title":"J Pharmacol"},{"key":"10660_CR25","doi-asserted-by":"publisher","unstructured":"Liu X, Chen B, Chen, J, Wang X, Dai X, Li Y, \u2026 Yang Y. A Cardiac-targeted nanozyme interrupts the inflammation-free radical cycle in myocardial infarction. Adv Mater . 2024;36(2): e2308477. https:\/\/doi.org\/10.1002\/adma.202308477.","DOI":"10.1002\/adma.202308477"},{"key":"10660_CR26","doi-asserted-by":"publisher","unstructured":"Hu D, Li R, Li Y, Wang M, Wang L, Wang S, \u2026 Wei, Q. Inflammation-targeted nanomedicines alleviate oxidative stress and reprogram macrophages polarization for myocardial infarction treatment. Adv Sci . 2024;11(21): e2308910. https:\/\/doi.org\/10.1002\/advs.202308910.","DOI":"10.1002\/advs.202308910"},{"issue":"3","key":"10660_CR27","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1021\/acsnano.2c07436","volume":"17","author":"W Liu","year":"2023","unstructured":"Liu W, Zhao N, Yin Q, Zhao X, Guo K, Xian Y, et al. Injectable hydrogels encapsulating dual-functional Au@Pt core-shell nanoparticles regulate infarcted microenvironments and enhance the therapeutic efficacy of stem cells through antioxidant and electrical integration. ACS Nano. 2023;17(3):2053\u201366. https:\/\/doi.org\/10.1021\/acsnano.2c07436.","journal-title":"ACS Nano."},{"issue":"47","key":"10660_CR28","doi-asserted-by":"publisher","first-page":"32650","DOI":"10.1021\/acsnano.4c10118","volume":"18","author":"J Zhang","year":"2024","unstructured":"Zhang J, Wang S, Sun Q, Zhang J, Shi X, Yao M, et al. Peroxynitrite-free nitric oxide-embedded nanoparticles maintain nitric oxide homeostasis for effective revascularization of myocardial infarcts. ACS Nano. 2024;18(47):32650\u201371. https:\/\/doi.org\/10.1021\/acsnano.4c10118.","journal-title":"ACS Nano."},{"issue":"8","key":"10660_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303101","volume":"13","author":"M Sun","year":"2024","unstructured":"Sun M, Hu N, Gao Y, Lv N, Fu X, Li Y, et al. Platelet membrane-encapsulated nanocomplexes based on profundity scavenging ROS strategy for myocardial infarction Therapy. Adv Healthcare Mater. 2024;13(8):e2303101. https:\/\/doi.org\/10.1002\/adhm.202303101.","journal-title":"Adv Healthcare Mater."},{"issue":"14","key":"10660_CR30","doi-asserted-by":"publisher","first-page":"13723","DOI":"10.1021\/acsnano.4c14869","volume":"19","author":"Y Gong","year":"2025","unstructured":"Gong Y, Xiao Y, Zhao C, Deng H, Liu H, Ke S, et al. Ultrasmall PtIr bimetallic nanozyme treats myocardial infarction via ischemic\/inflammatory cardiac microenvironment remodeling. ACS Nano. 2025;19(14):13723\u201339. https:\/\/doi.org\/10.1021\/acsnano.4c14869.","journal-title":"ACS Nano."},{"issue":"1","key":"10660_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","author":"SD Prabhu","year":"2016","unstructured":"Prabhu SD, Frangogiannis NG. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ Res. 2016;119(1):91\u2013112. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303577.","journal-title":"Circ Res."},{"issue":"11","key":"10660_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901783","volume":"9","author":"T Hong","year":"2020","unstructured":"Hong T, Wei Y, Xue X, Li Y, Dong H, Guo X, et al. A novel anti-coagulative nanocomplex in delivering miRNA-1 inhibitor against microvascular obstruction of myocardial infarction. Adv Healthcare Mater. 2020;9(11):e1901783. https:\/\/doi.org\/10.1002\/adhm.201901783.","journal-title":"Adv Healthcare Mater."},{"issue":"2","key":"10660_CR33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.nano.2017.12.004","volume":"14","author":"X Xue","year":"2018","unstructured":"Xue X, Shi X, Dong H, You S, Cao H, Wang K, et al. Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice. Nanomed : Nanotechnol Biol Med. 2018;14(2):619\u201331. https:\/\/doi.org\/10.1016\/j.nano.2017.12.004.","journal-title":"Nanomed : Nanotechnol Biol Med."},{"issue":"22","key":"10660_CR34","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1039\/d1na00568e","volume":"3","author":"H Yu","year":"2021","unstructured":"Yu H, Li Y, Zhang R, Shen M, Zhu Y, Zhang Q, et al. Inhibition of cardiomyocyte apoptosis post-acute myocardial infarction through the efficient delivery of microRNA-24 by silica nanoparticles. Nanoscale Adv. 2021;3(22):6379\u201385. https:\/\/doi.org\/10.1039\/d1na00568e.","journal-title":"Nanoscale Adv."},{"key":"10660_CR35","doi-asserted-by":"publisher","first-page":"1013910","DOI":"10.3389\/fchem.2022.1013910","volume":"10","author":"L You","year":"2022","unstructured":"You L, Wang Q, Ma Y, Li Y, Ye H, Xu L, Lei M. Precise dapagliflozin delivery by cardiac homing peptide functionalized mesoporous silica nanocarries for heart failure repair after myocardial infarction. Front Chem. 2022;10:1013910. https:\/\/doi.org\/10.3389\/fchem.2022.1013910.","journal-title":"Front Chem."},{"issue":"7","key":"10660_CR36","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/CIRCRESAHA.116.305381","volume":"116","author":"A Leask","year":"2015","unstructured":"Leask A. Getting to the heart of the matter: new insights into cardiac fibrosis. Circ Res. 2015;116(7):1269\u201376. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305381.","journal-title":"Circ Res."},{"issue":"11","key":"10660_CR37","doi-asserted-by":"publisher","first-page":"11412","DOI":"10.1021\/acsnano.5c00820","volume":"19","author":"X Zhong","year":"2025","unstructured":"Zhong X, Luo L, Wu J, Li W, Liu X, Ye T, et al. Adhesion-assisted antioxidant-engineered mesenchymal stromal cells for enhanced cardiac repair in myocardial infarction. ACS Nano. 2025;19(11):11412\u201326. https:\/\/doi.org\/10.1021\/acsnano.5c00820.","journal-title":"ACS Nano."},{"issue":"25","key":"10660_CR38","doi-asserted-by":"publisher","first-page":"7143","DOI":"10.1016\/j.cell.2024.09.034","volume":"187","author":"H Zhang","year":"2024","unstructured":"Zhang H, Thai PN, Shivnaraine RV, Ren L, Wu X, Siepe DH, et al. Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target. Cell. 2024;187(25):7143\u20137163.e22. https:\/\/doi.org\/10.1016\/j.cell.2024.09.034.","journal-title":"Cell."},{"issue":"6576","key":"10660_CR39","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.abm0594","volume":"375","author":"JG Rurik","year":"2022","unstructured":"Rurik JG, Tomb\u00e1cz I, Yadegari A, M\u00e9ndez Fern\u00e1ndez PO, Shewale SV, Li L, et al. CAR T cells produced in vivo to treat cardiac injury. Science (New York, N.Y.). 2022;375(6576):91\u20136. https:\/\/doi.org\/10.1126\/science.abm0594.","journal-title":"Science (New York, N.Y.)"},{"issue":"11","key":"10660_CR40","first-page":"12421","volume":"13","author":"H Ma","year":"2021","unstructured":"Ma H, Xu D, Liu F, Yao Q. 17-estradiol nanoparticles influence inflammatory response of myocardial infarction possibly through downregulation of miR-302b. Am J Transl Res. 2021;13(11):12421\u201330.","journal-title":"Am J Transl Res."},{"issue":"6","key":"10660_CR41","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1021\/acsnano.2c10042","volume":"17","author":"X Ji","year":"2023","unstructured":"Ji X, Meng Y, Wang Q, Tong T, Liu Z, Lin J, et al. Cysteine-based redox-responsive nanoparticles for fibroblast-targeted drug delivery in the treatment of myocardial infarction. ACS Nano. 2023;17(6):5421\u201334. https:\/\/doi.org\/10.1021\/acsnano.2c10042.","journal-title":"ACS Nano."},{"issue":"8","key":"10660_CR42","doi-asserted-by":"publisher","first-page":"7826","DOI":"10.1021\/acsnano.8b01977","volume":"12","author":"E Mihalko","year":"2018","unstructured":"Mihalko E, Huang K, Sproul E, Cheng K, Brown AC. Targeted treatment of ischemic and fibrotic complications of myocardial infarction Using a dual-delivery microgel therapeutic. ACS Nano. 2018;12(8):7826\u201337. https:\/\/doi.org\/10.1021\/acsnano.8b01977.","journal-title":"ACS Nano."},{"issue":"3","key":"10660_CR43","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1161\/CIRCULATIONAHA.123.067156","volume":"151","author":"W Derks","year":"2025","unstructured":"Derks W, Rode J, Collin S, Rost F, Heinke P, Hariharan A, et al. A latent cardiomyocyte regeneration potential in human heart disease. Circulation. 2025;151(3):245\u201357. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.067156.","journal-title":"Circulation."},{"issue":"11","key":"10660_CR44","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1161\/CIRCULATIONAHA.123.067592","volume":"150","author":"Y Bei","year":"2024","unstructured":"Bei Y, Zhu Y, Zhou J, Ai S, Yao J, Yin M, et al. Inhibition of Hmbox1 promotes cardiomyocyte survival and glucose metabolism through Gck activation in ischemia\/reperfusion injury. Circulation. 2024;150(11):848\u201366. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.067592.","journal-title":"Circulation."},{"key":"10660_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103713","volume":"74","author":"Q Zhou","year":"2021","unstructured":"Zhou Q, Deng J, Yao J, Song J, Meng D, Zhu Y, et al. Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction. eBioMedicine. 2021;74:103713. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103713.","journal-title":"eBioMedicine."},{"issue":"9","key":"10660_CR46","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1021\/acsnano.9b03343","volume":"13","author":"H Yang","year":"2019","unstructured":"Yang H, Qin X, Wang H, Zhao X, Liu Y, Wo HT, et al. An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano. 2019;13(9):9880\u201394. https:\/\/doi.org\/10.1021\/acsnano.9b03343.","journal-title":"ACS Nano."},{"issue":"11","key":"10660_CR47","doi-asserted-by":"publisher","first-page":"19551","DOI":"10.1021\/acsnano.2c10043","volume":"16","author":"Y Guan","year":"2022","unstructured":"Guan Y, Niu H, Wen J, Dang Y, Zayed M, Guan J. Rescuing cardiac cells and improving cardiac function by targeted delivery of oxygen-releasing nanoparticles after or even before acute myocardial infarction. ACS Nano. 2022;16(11):19551\u201366. https:\/\/doi.org\/10.1021\/acsnano.2c10043.","journal-title":"ACS Nano."},{"issue":"10","key":"10660_CR48","doi-asserted-by":"publisher","first-page":"15935","DOI":"10.1021\/acsnano.2c03060","volume":"16","author":"S Hu","year":"2022","unstructured":"Hu S, Zhu D, Li Z, Cheng K. Detachable microneedle patches deliver mesenchymal stromal cell factor-loaded nanoparticles for cardiac repair. ACS Nano. 2022;16(10):15935\u201345. https:\/\/doi.org\/10.1021\/acsnano.2c03060.","journal-title":"ACS Nano."},{"issue":"6","key":"10660_CR49","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1097\/FJC.0000000000000920","volume":"76","author":"L Kraus","year":"2020","unstructured":"Kraus L, Mohsin S. Role of stem cell-derived microvesicles in cardiovascular disease. J Cardiovasc Pharmacol. 2020;76(6):650\u20137. https:\/\/doi.org\/10.1097\/FJC.0000000000000920.","journal-title":"J Cardiovasc Pharmacol."},{"issue":"1","key":"10660_CR50","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13287-024-03891-1","volume":"15","author":"H Lee","year":"2024","unstructured":"Lee H, Cho H-J, Han Y, Lee SH. Mid- to long-term efficacy and safety of stem cell therapy for acute myocardial infarction: a systematic review and meta-analysis. Stem Cell Res Ther. 2024;15(1):290. https:\/\/doi.org\/10.1186\/s13287-024-03891-1.","journal-title":"Stem Cell Res Ther."},{"issue":"7","key":"10660_CR51","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1096\/fj.06-6769com","volume":"21","author":"J Nussbaum","year":"2007","unstructured":"Nussbaum J, Minami E, Laflamme MA, Virag JAI, Ware CB, Masino A, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J: Official Publication Federation American Societies. Exp Biol. 2007;21(7):1345\u201357. https:\/\/doi.org\/10.1096\/fj.06-6769com.","journal-title":"Exp Biol."},{"key":"10660_CR52","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.biomaterials.2015.10.01053","volume":"74","author":"K Zhu","year":"2016","unstructured":"Zhu K, Wu M, Lai H, Guo C, Li J, Wang Y, et al. Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair. Biomater. 2016;74:188\u201399. https:\/\/doi.org\/10.1016\/j.biomaterials.2015.10.01053.","journal-title":"Biomater"},{"issue":"4","key":"10660_CR53","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/stem.2777","volume":"36","author":"Q Ma","year":"2018","unstructured":"Ma Q, Yang J, Huang X, Guo W, Li S, Zhou H, et al. Poly(Lactide-Co-Glycolide)-monomethoxy-poly-(Polyethylene Glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue. Stem Cells (Dayton, Ohio). 2018;36(4):540\u201350. https:\/\/doi.org\/10.1002\/stem.2777.","journal-title":"Stem Cells (Dayton, Ohio)"},{"issue":"6","key":"10660_CR54","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1021\/acsnano.7b00221","volume":"11","author":"T Hao","year":"2017","unstructured":"Hao T, Li J, Yao F, Dong D, Wang Y, Yang B, Wang C. Injectable fullerenol\/alginate hydrogel for suppression of oxidative stress damage in brown adipose-derived stem cells and cardiac repair. ACS Nano. 2017;11(6):5474\u201388. https:\/\/doi.org\/10.1021\/acsnano.7b00221.","journal-title":"ACS Nano."},{"key":"10660_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.135976","volume":"707","author":"Y Dong","year":"2020","unstructured":"Dong Y, Hong M, Dai R, Wu H, Zhu P. Engineered bioactive nanoparticles incorporated biofunctionalized ECM\/silk proteins based cardiac patches combined with MSCs for the repair of myocardial infarction: In vitro and in vivo evaluations. Sci Total Environ. 2020;707:135976. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135976.","journal-title":"Sci Total Environ."},{"issue":"10","key":"10660_CR56","doi-asserted-by":"publisher","first-page":"9738","DOI":"10.1021\/acsnano.7b01008","volume":"11","author":"J Tang","year":"2017","unstructured":"Tang J, Cui X, Caranasos TG, Hensley MT, Vandergriff AC, Hartanto Y, et al. Heart repair using nanogel-encapsulated human cardiac stem cells in mice and pigs with myocardial infarction. ACS Nano. 2017;11(10):9738\u201349. https:\/\/doi.org\/10.1021\/acsnano.7b01008.","journal-title":"ACS Nano"},{"key":"10660_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125139","volume":"244","author":"H Wang","year":"2023","unstructured":"Wang H, Guo Y, Hu Y, Zhou Y, Chen Y, Huang X, et al. Ultrasound-controlled nano oxygen carriers enhancing cell viability in 3D GelMA hydrogel for the treatment of myocardial infarction. Int J Biol Macromol. 2023;244:125139. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.125139.","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"10660_CR58","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00395-014-0459-0","volume":"110","author":"XM Yang","year":"2015","unstructured":"Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, et al. Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia\/reperfusion. Basic Res. Cardiol. 2015;110(2):3. https:\/\/doi.org\/10.1007\/s00395-014-0459-0.","journal-title":"Basic Res. Cardiol."},{"issue":"12","key":"10660_CR59","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1084\/jem.20070885","volume":"204","author":"M Nahrendorf","year":"2007","unstructured":"Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204(12):3037\u201347. https:\/\/doi.org\/10.1084\/jem.20070885.","journal-title":"J Exp Med."},{"issue":"6","key":"10660_CR60","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/cvr\/cvz336","volume":"116","author":"C Peet","year":"2020","unstructured":"Peet C, Ivetic A, Bromage DI, Shah AM. Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc Res. 2020;116(6):1101\u201312. https:\/\/doi.org\/10.1093\/cvr\/cvz336.","journal-title":"Cardiovasc Res."},{"key":"10660_CR61","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.biopha.2018.12.095","volume":"111","author":"Y Peng","year":"2019","unstructured":"Peng Y, Chen B, Zhao J, Peng Z, Xu W, Yu G. Effect of intravenous transplantation of hUCB-MSCs on M1\/M2 subtype conversion in monocyte\/macrophages of AMI mice. Biomed Pharmacother. 2019;111:624\u201330. https:\/\/doi.org\/10.1016\/j.biopha.2018.12.095.","journal-title":"Biomed Pharmacother."},{"issue":"15","key":"10660_CR62","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.jacc.2013.11.023","volume":"63","author":"G Courties","year":"2014","unstructured":"Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, et al. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am College Cardiol. 2014;63(15):1556\u201366. https:\/\/doi.org\/10.1016\/j.jacc.2013.11.023.","journal-title":"J Am College Cardiol."},{"issue":"4","key":"10660_CR63","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1536\/ihj.16-457","volume":"58","author":"Y Mao","year":"2017","unstructured":"Mao Y, Koga J-I, Tokutome M, Matoba T, Ikeda G, Nakano K, Egashira K. Nanoparticle-mediated delivery of pitavastatin to monocytes\/macrophages inhibits left ventricular remodeling after acute myocardial infarction by inhibiting monocyte-mediated inflammation. Int Heart J. 2017;58(4):615\u201323. https:\/\/doi.org\/10.1536\/ihj.16-457.","journal-title":"Int Heart J."},{"issue":"6","key":"10660_CR64","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s10557-021-07239-2","volume":"36","author":"L Wang","year":"2022","unstructured":"Wang L, Peng Y, Song L, Xia D, Li C, Li Z, et al. Colchicine-containing nanoparticles attenuates acute myocardial infarction injury by inhibiting inflammation. Cardiovasc Drugs Ther. 2022;36(6):1075\u201389. https:\/\/doi.org\/10.1007\/s10557-021-07239-2.","journal-title":"Cardiovasc Drugs Ther."},{"issue":"9","key":"10660_CR65","doi-asserted-by":"publisher","first-page":"5885","DOI":"10.1021\/acs.nanolett.8b02578","volume":"18","author":"T Bejerano","year":"2018","unstructured":"Bejerano T, Etzion S, Elyagon S, Etzion Y, Cohen S. Nanoparticle delivery of miRNA-21 mimic to cardiac macrophages improves myocardial remodeling after myocardial infarction. Nano Lett. 2018;18(9):5885\u201391. https:\/\/doi.org\/10.1021\/acs.nanolett.8b02578.","journal-title":"Nano Lett."},{"key":"10660_CR66","doi-asserted-by":"publisher","first-page":"e2100505","DOI":"10.1002\/advs.202100505","volume-title":"Adv Sci","author":"J Zhou","year":"2021","unstructured":"Zhou J, Liu W, Zhao X, Xian Y, Wu W, Zhang X, \u2026 Wang C. Natural melanin\/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization. Adv Sci. 2021;8(20): e2100505. https:\/\/doi.org\/10.1002\/advs.202100505."},{"issue":"13","key":"10660_CR67","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209041","volume":"35","author":"W Chen","year":"2023","unstructured":"Chen W, Wang C, Liu W, Zhao B, Zeng Z, Long F, et al. Matrix-Metalloproteinase-responsive hydrogel system for modulating the immune microenvironment in myocardial infarction. Adv Mater. 2023;35(13):e2209041. https:\/\/doi.org\/10.1002\/adma.202209041.","journal-title":"Adv Mater."},{"issue":"1","key":"10660_CR68","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12951-023-01980-6","volume":"21","author":"K Wang","year":"2023","unstructured":"Wang K, Zhu K, Zhu Z, Shao F, Qian R, Wang C, et al. Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel. J Nanobiotechnol. 2023;21(1):227. https:\/\/doi.org\/10.1186\/s12951-023-01980-6.","journal-title":"J Nanobiotechnol."},{"issue":"1","key":"10660_CR69","doi-asserted-by":"publisher","first-page":"eadp7126","DOI":"10.1126\/sciadv.adp7126","volume":"11","author":"Z Ma","year":"2025","unstructured":"Ma Z, Li M, Guo R, Tian Y, Zheng Y, Huang B, et al. Treating myocardial infarction via a nano-ultrasonic contrast agent mediated high-efficiency drug delivery system targeting macrophages. Sci Adv. 2025;11(1):eadp7126. https:\/\/doi.org\/10.1126\/sciadv.adp7126.","journal-title":"Sci Adv"},{"key":"10660_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122890","volume":"314","author":"K Wang","year":"2025","unstructured":"Wang K, Sun Y, Zhu K, Liu Y, Zheng X, Yang Z, et al. Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery. Biomaterials. 2025;314:122890. https:\/\/doi.org\/10.1016\/j.biomaterials.2024.122890.","journal-title":"Biomaterials."},{"issue":"8","key":"10660_CR71","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1172\/JCI93868","volume":"127","author":"L He","year":"2017","unstructured":"He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, et al. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Investigation. 2017;127(8):2968\u201381. https:\/\/doi.org\/10.1172\/JCI93868.","journal-title":"J Clin Investigation."},{"issue":"4","key":"10660_CR72","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41419-022-04754-4","volume":"13","author":"Y Zheng","year":"2022","unstructured":"Zheng Y, Lin J, Liu D, Wan G, Gu X, Ma J. Nogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling. Cell Death Dis. 2022;13(4):306. https:\/\/doi.org\/10.1038\/s41419-022-04754-4.","journal-title":"Cell Death Dis."},{"key":"10660_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116994","volume":"177","author":"M Wang","year":"2024","unstructured":"Wang M, Liu X, Ding B, Lu Q, Ma J. SGLT2 inhibitor Dapagliflozin alleviates cardiac dysfunction and fibrosis after myocardial infarction by activating PXR and promoting angiogenesis. Biomed Pharmacother. 2024;177:116994. https:\/\/doi.org\/10.1016\/j.biopha.2024.116994.","journal-title":"Biomed Pharmacother."},{"issue":"10","key":"10660_CR74","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411554","volume":"12","author":"J Yang","year":"2025","unstructured":"Yang J, Duan C, Wang P, Zhang S, Gao Y, Lu S, Ji Y. 4-Octyl Itaconate alleviates myocardial ischemia-reperfusion injury through promoting angiogenesis via erk signaling activation. Adv Sci (Weinh). 2025;12(10):e2411554. https:\/\/doi.org\/10.1002\/advs.202411554.","journal-title":"Adv Sci (Weinh)."},{"issue":"6599","key":"10660_CR75","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1126\/science.abn3027","volume":"376","author":"MR Reboll","year":"2022","unstructured":"Reboll MR, Klede S, Taft MH, Cai CL, Field LJ, Lavine KJ, et al. Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science (New York, N.Y.). 2022;376(6599):1343\u20137. https:\/\/doi.org\/10.1126\/science.abn3027.","journal-title":"Science (New York, N.Y.)"},{"issue":"11","key":"10660_CR76","doi-asserted-by":"publisher","first-page":"8107","DOI":"10.1021\/acsnano.3c11661","volume":"18","author":"Y Shao","year":"2024","unstructured":"Shao Y, Xu C, Zhu S, Wu J, Sun C, Huang S, et al. One endothelium-targeted combined nucleic acid delivery system for myocardial infarction therapy. ACS Nano. 2024;18(11):8107\u201324. https:\/\/doi.org\/10.1021\/acsnano.3c11661.","journal-title":"ACS Nano."},{"issue":"20","key":"10660_CR77","doi-asserted-by":"publisher","first-page":"20246","DOI":"10.1021\/acsnano.3c06229","volume":"17","author":"C Song","year":"2023","unstructured":"Song C, Kong F, Nong H, Cai L, Tian Y, Hou H, et al. Ammonium persulfate-loaded carboxylic gelatin-methacrylate nanoparticles promote cardiac repair by activating epicardial epithelial-mesenchymal transition via autophagy and the mTOR Pathway. ACS Nano. 2023;17(20):20246\u201361. https:\/\/doi.org\/10.1021\/acsnano.3c06229.","journal-title":"ACS Nano."},{"key":"10660_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125187","volume":"671","author":"J Wang","year":"2025","unstructured":"Wang J, Lin C, Li X, Wei J, Wang Y, Li R, et al. Polydopamine nanoparticles loaded with sodium ferulate for targeted therapy of myocardial infarction in endothelial cells. Int J Pharm. 2025;671:125187. https:\/\/doi.org\/10.1016\/j.ijpharm.2025.125187.","journal-title":"Int J Pharm."},{"key":"10660_CR79","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bioactmat.2022.11.016","volume":"23","author":"D Han","year":"2023","unstructured":"Han D, Wang F, Qiao Z, Wang B, Zhang Y, Jiang Q, et al. Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury. Bioactive Mater. 2023;23:369\u201382. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.11.016.","journal-title":"Bioactive Mater"},{"key":"10660_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120811","volume":"273","author":"X Song","year":"2021","unstructured":"Song X, Wang X, Zhang J, Shen S, Yin W, Ye G, et al. A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair. Biomaterials. 2021;273:120811. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.120811.","journal-title":"Biomaterials."},{"issue":"9","key":"10660_CR81","doi-asserted-by":"publisher","first-page":"9416","DOI":"10.1021\/acsnano.5b04137","volume":"9","author":"K Margulis","year":"2015","unstructured":"Margulis K, Neofytou EA, Beygui RE, Zare RN. Celecoxib nanoparticles for therapeutic angiogenesis. ACS Nano. 2015;9(9):9416\u201326. https:\/\/doi.org\/10.1021\/acsnano.5b04137.","journal-title":"ACS Nano."},{"key":"10660_CR82","doi-asserted-by":"publisher","first-page":"rbad036","DOI":"10.1093\/rb\/rbad036","volume":"10","author":"J Feng","year":"2023","unstructured":"Feng J, Xing M, Qian W, Qiu J, Liu X. An injectable hydrogel combining medicine and matrix with anti-inflammatory and proangiogenic properties for potential treatment of myocardial infarction. Regenerative Biomater. 2023;10:rbad036. https:\/\/doi.org\/10.1093\/rb\/rbad036.","journal-title":"Regenerative Biomater."},{"issue":"8","key":"10660_CR83","doi-asserted-by":"publisher","first-page":"8050","DOI":"10.1021\/nn5020787","volume":"8","author":"A Paul","year":"2014","unstructured":"Paul A, Hasan A, Kindi HA, Gaharwar AK, Rao VTS, Nikkhah M, et al. Injectable graphene oxide\/hydrogel based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano. 2014;8(8):8050\u201362. https:\/\/doi.org\/10.1021\/nn5020787.","journal-title":"ACS Nano."},{"issue":"9","key":"10660_CR84","doi-asserted-by":"publisher","first-page":"eabd6740","DOI":"10.1126\/sciadv.abd6740","volume":"7","author":"Y Li","year":"2021","unstructured":"Li Y, Chen X, Jin R, Chen L, Dang M, Cao H, et al. Injectable hydrogel with MSNs\/microRNA-21\u20135p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021;7(9):eabd6740. https:\/\/doi.org\/10.1126\/sciadv.abd6740.","journal-title":"Sci Adv."},{"issue":"40","key":"10660_CR85","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902900","volume":"31","author":"C Fan","year":"2019","unstructured":"Fan C, Shi J, Zhuang Y, Zhang L, Huang L, Yang W, et al. Myocardial-infarction-responsive smart hydrogels targeting matrix metalloproteinase for on-demand growth factor delivery. Adv Mater. 2019;31(40):e1902900. https:\/\/doi.org\/10.1002\/adma.201902900.","journal-title":"Adv Mater."},{"issue":"4","key":"10660_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009388","volume":"18","author":"C Liang","year":"2022","unstructured":"Liang C, Li Q, Wang K, Du Y, Wang W, Zhang H. Mechanisms of ventricular arrhythmias elicited by coexistence of multiple electrophysiological remodeling in ischemia: A simulation study. PLoS Comput Biol. 2022;18(4):e1009388. https:\/\/doi.org\/10.1371\/journal.pcbi.1009388.","journal-title":"PLoS Comput Biol."},{"issue":"1","key":"10660_CR87","doi-asserted-by":"publisher","first-page":"19964","DOI":"10.1038\/s41598-020-76681-3","volume":"10","author":"K Tsumoto","year":"2020","unstructured":"Tsumoto K, Ashihara T, Naito N, Shimamoto T, Amano A, Kurata Y, Kurachi Y. Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome. Sci Rep. 2020;10(1):19964. https:\/\/doi.org\/10.1038\/s41598-020-76681-3.","journal-title":"Sci Rep."},{"key":"10660_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110896","volume":"132","author":"B Tao","year":"2020","unstructured":"Tao B, Liu Z, Wei F, Fan S, Cui S, Xia H, Xu L. Over-expression of Kv4.3 gene reverses cardiac remodeling and transient outward K+ current (Ito) reduction via CaMKII inhibition in myocardial infarction. Biomed Pharmacother. 2020;132:110896. https:\/\/doi.org\/10.1016\/j.biopha.2020.110896.","journal-title":"Biomed Pharmacother."},{"issue":"10","key":"10660_CR89","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/s41551-021-00796-9","volume":"5","author":"L Wang","year":"2021","unstructured":"Wang L, Liu Y, Ye G, He Y, Li B, Guan Y, et al. Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs. Nat Biomed Eng. 2021;5(10):1157\u201373. https:\/\/doi.org\/10.1038\/s41551-021-00796-9.","journal-title":"Nat Biomed Eng."},{"key":"10660_CR90","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.actbio.2021.04.027","volume":"139","author":"C Yu","year":"2022","unstructured":"Yu C, Yao F, Li J. Rational design of injectable conducting polymer-based hydrogels for tissue engineering. Acta Biomater. 2022;139:4\u201321. https:\/\/doi.org\/10.1016\/j.actbio.2021.04.027.","journal-title":"Acta Biomater."},{"issue":"10","key":"10660_CR91","doi-asserted-by":"publisher","first-page":"16234","DOI":"10.1021\/acsnano.2c05168","volume":"16","author":"C Yu","year":"2022","unstructured":"Yu C, Yue Z, Shi M, Jiang L, Chen S, Yao M, et al. An intrapericardial injectable hydrogel patch for mechanical-electrical coupling with infarcted myocardium. ACS Nano. 2022;16(10):16234\u201348. https:\/\/doi.org\/10.1021\/acsnano.2c05168.","journal-title":"ACS Nano."},{"issue":"13","key":"10660_CR92","doi-asserted-by":"publisher","first-page":"12290","DOI":"10.1021\/acsnano.3c00933","volume":"17","author":"M Lee","year":"2023","unstructured":"Lee M, Park J, Choe G, Lee S, Kang BG, Jun JH, et al. A conductive and adhesive hydrogel composed of mxene nanoflakes as a paintable cardiac patch for infarcted heart repair. ACS Nano. 2023;17(13):12290\u2013304. https:\/\/doi.org\/10.1021\/acsnano.3c00933.","journal-title":"ACS Nano."},{"issue":"17","key":"10660_CR93","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1002\/adfm.201500365","volume":"25","author":"J Park","year":"2015","unstructured":"Park J, Kim YS, Ryu S, Kang WS, Park S, Han J, et al. Graphene potentiates the myocardial repair efficacy of mesenchymal stem cells by stimulating the expression of angiogenic growth factors and gap junction protein. Adv Functional Mater. 2015;25(17):2590\u2013600. https:\/\/doi.org\/10.1002\/adfm.201500365.","journal-title":"Adv Functional Mater."},{"issue":"23","key":"10660_CR94","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704235","volume":"30","author":"S Liang","year":"2018","unstructured":"Liang S, Zhang Y, Wang H, Xu Z, Chen J, Bao R, et al. Paintable and rapidly bondable conductive hydrogels as therapeutic cardiac patches. Adv Mater. 2018;30(23):e1704235. https:\/\/doi.org\/10.1002\/adma.201704235.","journal-title":"Adv Mater."},{"issue":"12","key":"10660_CR95","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.7150\/thno.25504","volume":"8","author":"J Zhou","year":"2018","unstructured":"Zhou J, Yang X, Liu W, Wang C, Shen Y, Zhang F, et al. Injectable OPF\/graphene oxide hydrogels provide mechanical support and enhance cell electrical signaling after implantation into myocardial infarct. Theranostics. 2018;8(12):3317\u201330. https:\/\/doi.org\/10.7150\/thno.25504.","journal-title":"Theranostics."},{"issue":"14","key":"10660_CR96","doi-asserted-by":"publisher","first-page":"10216","DOI":"10.1021\/acsnano.4c00509","volume":"18","author":"F Zhang","year":"2024","unstructured":"Zhang F, Zhang Y, Qian S, Qian X, Jiao J, Ma B, et al. Injectable and conductive nanomicelle hydrogel with \u03b1-tocopherol encapsulation for enhanced myocardial infarction repair. ACS Nano. 2024;18(14):10216\u201329. https:\/\/doi.org\/10.1021\/acsnano.4c00509.","journal-title":"ACS Nano."},{"issue":"3","key":"10660_CR97","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cardfail.2009.01.013","volume":"15","author":"BE Jaski","year":"2009","unstructured":"Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B. \u2026 Calcium up-regulation by percutaneous administration of gene therapy in cardiac disease (CUPID) Trial Investigators. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1\/2 clinical trial. J Cardiac Failure. 2009;15(3):171\u201381. https:\/\/doi.org\/10.1016\/j.cardfail.2009.01.013.","journal-title":"J Cardiac Failure."},{"issue":"23","key":"10660_CR98","doi-asserted-by":"publisher","first-page":"e471","DOI":"10.1161\/CIR.0000000000001296","volume":"150","author":"Y Kim","year":"2024","unstructured":"Kim Y, Landstrom AP, Shah SH, Wu JC, Seidman CE. & on behalf of the American Heart Association. Gene therapy in cardiovascular disease: recent advances and future directions in science: a science advisory from the American Heart Association. Circulation. 2024;150(23):e471\u201380. https:\/\/doi.org\/10.1161\/CIR.0000000000001296.","journal-title":"Circulation."},{"issue":"21","key":"10660_CR99","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1093\/eurheartj\/ehw019","volume":"37","author":"JS Hulot","year":"2016","unstructured":"Hulot JS, Ishikawa K, Hajjar RJ. Gene therapy for the treatment of heart failure: promise postponed. Eur Heart J. 2016;37(21):1651\u20138. https:\/\/doi.org\/10.1093\/eurheartj\/ehw019.","journal-title":"Eur Heart J."},{"key":"10660_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.102040","volume":"34","author":"Y Lu","year":"2023","unstructured":"Lu Y, Godbout K, Lamothe G, Tremblay JP. CRISPR-Cas9 delivery strategies with engineered extracellular vesicles. Mol Ther Nucleic Acids. 2023;34:102040. https:\/\/doi.org\/10.1016\/j.omtn.2023.102040.","journal-title":"Mol Ther Nucleic Acids."},{"issue":"3","key":"10660_CR101","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s12265-025-10614-1","volume":"18","author":"W Wang","year":"2025","unstructured":"Wang W, Xu D, Ding J, Pan Y, Wang F, Su S, et al. Nanotechnology innovations in myocardial infarction: diagnosis, treatment and the way forward. J Cardiovascular Translational Res. 2025;18(3):484\u201397. https:\/\/doi.org\/10.1007\/s12265-025-10614-1.","journal-title":"J Cardiovascular Translational Res."},{"issue":"Pt 1","key":"10660_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131175","volume":"266","author":"S Zhu","year":"2024","unstructured":"Zhu S, Zhang W, Xu C, Huang J, Zou C. An injectable polyacrylamide\/chitosan-based hydrogel with highly adhesive, stretchable and electroconductive properties loaded with irbesartan for treatment of myocardial ischemia-reperfusion injury. Int J Biol Macromol. 2024;266(Pt 1):131175. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.131175.","journal-title":"Int J Biol Macromol."},{"key":"10660_CR103","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jconrel.2022.05.056","volume":"348","author":"H Ding","year":"2022","unstructured":"Ding H, Tan P, Fu S, Tian X, Zhang H, Ma X, et al. Preparation and application of pH-responsive drug delivery systems. J Control Release. 2022;348:206\u201338. https:\/\/doi.org\/10.1016\/j.jconrel.2022.05.056.","journal-title":"J Control Release."},{"key":"10660_CR104","doi-asserted-by":"publisher","first-page":"1469393","DOI":"10.3389\/fbioe.2024.1469393","volume":"12","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Jiang M, Wang T. Reactive oxygen species (ROS)-responsive biomaterials for treating myocardial ischemiareperfusion injury. Front Bioengineering Biotechnol. 2024;12:1469393. https:\/\/doi.org\/10.3389\/fbioe.2024.1469393.","journal-title":"Front Bioengineering Biotechnol."},{"issue":"11","key":"10660_CR105","doi-asserted-by":"publisher","first-page":"eaat9365","DOI":"10.1126\/sciadv.aat9365","volume":"4","author":"J Tang","year":"2018","unstructured":"Tang J, Wang J, Huang K, Ye Y, Su T, Qiao L, et al. Cardiac cell-integrated microneedle patch for treating myocardial infarction. Sci Adv. 2018;4(11):eaat9365. https:\/\/doi.org\/10.1126\/sciadv.aat9365.","journal-title":"Sci Adv."},{"issue":"5","key":"10660_CR106","doi-asserted-by":"publisher","first-page":"2400498","DOI":"10.1002\/smsc.202400498","volume":"5","author":"Z Zheng","year":"2025","unstructured":"Zheng Z, Zhu S, Wang X, Wu H, Fu M, Hu H, et al. Understanding the mechanism of cardiotoxicity induced by nanomaterials: A comprehensive review. Small Sci. 2025;5(5):2400498. https:\/\/doi.org\/10.1002\/smsc.202400498.","journal-title":"Small Sci."},{"issue":"10","key":"10660_CR107","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1021\/nl2025882","volume":"11","author":"T Dvir","year":"2011","unstructured":"Dvir T, Bauer M, Schroeder A, Tsui JH, Anderson DG, Langer R, et al. Nanoparticles targeting the infarcted heart. Nano Lett. 2011;11(10):4411\u20134. https:\/\/doi.org\/10.1021\/nl2025882.","journal-title":"Nano Lett."},{"issue":"6","key":"10660_CR108","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1021\/acs.nanolett.1c00168","volume":"21","author":"B Li","year":"2021","unstructured":"Li B, Chu T, Wei J, Zhang Y, Qi F, Lu Z, et al. Platelet-membrane-coated nanoparticles enable vascular disrupting agent combining anti-angiogenic drug for improved tumor vessel impairment. Nano Lett. 2021;21(6):2588\u201395. https:\/\/doi.org\/10.1021\/acs.nanolett.1c00168.","journal-title":"Nano Lett."},{"key":"10660_CR109","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/978-1-60761-609-2_26","volume":"624","author":"A Gaitanis","year":"2010","unstructured":"Gaitanis A, Staal S. Liposomal doxorubicin and nab-paclitaxel: nanoparticle cancer chemotherapy in current clinical use. Methods Mol Biol. 2010;624:385\u201392. https:\/\/doi.org\/10.1007\/978-1-60761-609-2_26.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10660_CR110","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1038\/s41467-024-50312-1","volume":"15","author":"H Weng","year":"2024","unstructured":"Weng H, Zou W, Tian F, Xie H, Liu A, Liu W, et al. Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice. Nat Commun. 2024;15(1):6058. https:\/\/doi.org\/10.1038\/s41467-024-50312-1.","journal-title":"Nat Commun."},{"issue":"9","key":"10660_CR111","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1161\/CIRCULATIONAHA.123.065005","volume":"150","author":"J Li","year":"2024","unstructured":"Li J, Sun S, Zhu D, Mei X, Lyu Y, Huang K, et al. Inhalable stem cell exosomes promote heart repair after myocardial infarction. Circulation. 2024;150(9):710\u201323. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.065005.","journal-title":"Circulation."},{"issue":"16","key":"10660_CR112","doi-asserted-by":"publisher","first-page":"6948","DOI":"10.1021\/ja301621z","volume":"134","author":"D Chen","year":"2012","unstructured":"Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, et al. Rapid discovery of potent siRNAcontaining lipid nanoparticles enabled by controlled microfluidic formulation. J Am Chem Soc. 2012;134(16):6948\u201351. https:\/\/doi.org\/10.1021\/ja301621z.","journal-title":"J Am Chem Soc."},{"issue":"36","key":"10660_CR113","doi-asserted-by":"publisher","first-page":"24622","DOI":"10.1021\/acsnano.3c07878","volume":"18","author":"X Cui","year":"2024","unstructured":"Cui X, Guo J, Yuan P, Dai Y, Du P, Yu F, et al. Bioderived nanoparticles for cardiac repair. ACS Nano. 2024;18(36):24622\u201349. https:\/\/doi.org\/10.1021\/acsnano.3c07878.","journal-title":"ACS Nano."},{"key":"10660_CR114","doi-asserted-by":"publisher","unstructured":"Mlynska A, Dobrovolskiene N, Suveizde K, Lukaseviciute G, Sagini K, Gracia BM, et al. Exercise-induced extracellular vesicles delay tumor development by igniting inflammation in an immunologically cold triple-negative breast cancer mouse model. J Sport Health Sci. 2025:101041. https:\/\/doi.org\/10.1016\/j.jshs.2025.101041.","DOI":"10.1016\/j.jshs.2025.101041"},{"issue":"2","key":"10660_CR115","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300141","volume":"8","author":"J Jiang","year":"2024","unstructured":"Jiang J, Zhang X, Wang H, Spanos M, Jiang F, Ni L, et al. Closer to the heart: Harnessing the power of targeted extracellular vesicle therapies. Adv Biol. 2024;8(2):e2300141. https:\/\/doi.org\/10.1002\/adbi.202300141.","journal-title":"Adv Biol."},{"key":"10660_CR116","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jconrel.2021.01.018","volume":"331","author":"JY Kang","year":"2021","unstructured":"Kang JY, Kim H, Mun D, Yun N, Joung B. Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction. J Control Release. 2021;331:62\u201373. https:\/\/doi.org\/10.1016\/j.jconrel.2021.01.018.","journal-title":"J Control Release."},{"issue":"10","key":"10660_CR117","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12371","volume":"12","author":"JY Kang","year":"2023","unstructured":"Kang JY, Mun D, Chun Y, Park DS, Kim H, Yun N, Joung B. Engineered small extracellular vesicle-mediated NOX4 siRNA delivery for targeted therapy of cardiac hypertrophy. J Extracell Vesicles. 2023;12(10):e12371. https:\/\/doi.org\/10.1002\/jev2.12371.","journal-title":"J Extracell Vesicles."},{"key":"10660_CR118","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.jconrel.2024.05.023","volume":"370","author":"D Mun","year":"2024","unstructured":"Mun D, Kang JY, Kim H, Yun N, Joung B. Small extracellular vesicle-mediated CRISPR-Cas9 RNP delivery for cardiacspecific genome editing. J Control Release. 2024;370:798\u2013810. https:\/\/doi.org\/10.1016\/j.jconrel.2024.05.023.","journal-title":"J Control Release."}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10660-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-025-10660-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10660-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:12:14Z","timestamp":1763565134000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-025-10660-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":118,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10660"],"URL":"https:\/\/doi.org\/10.1007\/s12265-025-10660-9","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]},"assertion":[{"value":"11 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Not Applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Committee Approval"}},{"value":"No human and animal studies were carried out by the authors for this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Prof. Junjie Xiao is one of the associate editors of Journal of Cardiovascular Translational Research. Other authors declare no conflict of interest.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}}]}}