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Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluated coronary computed tomography angiography (CCTA)-based computational fluid dynamics (CFD) for predicting plaque dynamics in coronary artery disease. We retrospectively analyzed 22 patients (34 lesions) with paired CCTAs (mean interval 2\u00a0years). Lesions were categorized as progression (increase in diameter stenosis\u2009\u2265\u20095%), stable (change within\u2009\u2212\u20095% to 5%), or regression (decrease in diameter stenosis\u2009\u2265\u20095%). Hemodynamic indices were normalized to adjacent non-diseased segments. Logistic regression identified predictors: normalized minimum wall shear stress (odds ratio (OR)\u2009=\u20090.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and maximum helicity (OR\u2009=\u20091.44,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) predicted progression; average vorticity (OR\u2009=\u20090.13,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) and gradient oscillatory number (OR\u2009=\u20090.10, p\u2009=\u20090.001) predicted regression. Receiver operating characteristic (ROC) analysis showed good discrimination (area under the curve (AUC)\u2009=\u20090.78 for progression, 0.83 for regression). These noninvasive imaging- and hemodynamic-derived markers, which were independently associated with lesion progression, may enhance coronary artery disease risk stratification by identifying high-risk plaques beyond stenosis severity, thereby informing individualized follow-up and treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s12265-025-10735-7","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T09:37:34Z","timestamp":1767433054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemodynamic Study of Plaque Progression and Regression Based on Coronary CTA Imaging using Computational Fluid Dynamics Method: Preliminary Results"],"prefix":"10.1007","volume":"19","author":[{"given":"Shumin","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochang","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-7977","authenticated-orcid":false,"given":"Changqing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"10735_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000115120","volume":"45","author":"RJ Esper","year":"2008","unstructured":"Esper RJ, Vilari\u00f1o JO, Machado RA, Paragano A. 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