{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:36:27Z","timestamp":1780619787500,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Yale Department of Surgery"},{"DOI":"10.13039\/100021854","name":"Society for Vascular Surgery","doi-asserted-by":"publisher","award":["Clinical Research Seed Grant"],"award-info":[{"award-number":["Clinical Research Seed Grant"]}],"id":[{"id":"10.13039\/100021854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s12265-025-10737-5","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:11:00Z","timestamp":1770304260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PAD-associated Genetic Variants are More Strongly Associated with Surgical Intervention than Premature Onset"],"prefix":"10.1007","volume":"19","author":[{"given":"Jiaqi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Alameddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt","family":"Scharfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassius I. Ochoa","family":"Chaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-8704","authenticated-orcid":false,"given":"Andrew T.","family":"DeWan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"issue":"3","key":"10737_CR1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","volume":"14","author":"FGR Fowkes","year":"2017","unstructured":"Fowkes FGR, Aboyans V, Fowkes FJI, McDermott MM, Sampson UKA, Criqui MH. Peripheral artery disease: epidemiology and global perspectives. Nat Rev Cardiol. 2017;14(3):156\u201370.","journal-title":"Nat Rev Cardiol"},{"key":"10737_CR2","doi-asserted-by":"crossref","unstructured":"Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, et al. 2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: executive summary: a report of the american college of cardiology\/american heart association task force on clinical practice guidelines. Circulation. 2017 Mar 21;135(12):e686\u2013725.","DOI":"10.1161\/CIR.0000000000000501"},{"key":"10737_CR3","unstructured":"Writing Committee Members, Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, et al. 2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024 Jun 18;83(24):2497\u2013604."},{"issue":"87","key":"10737_CR4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.avsg.2022.07.007","volume":"1","author":"TI Kim","year":"2022","unstructured":"Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, et al. Major adverse limb events among patients with premature peripheral artery disease compared with those at the common age undergoing revascularization in the vascular quality initiative. Ann Vasc Surg. 2022;1(87):188\u201397.","journal-title":"Ann Vasc Surg"},{"issue":"6","key":"10737_CR5","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.amjcard.2014.06.029","volume":"114","author":"M Khaleghi","year":"2014","unstructured":"Khaleghi M, Isseh IN, Bailey KR, Kullo IJ. Family history as a risk factor for peripheral arterial disease. Am J Cardiol. 2014;114(6):928\u201332.","journal-title":"Am J Cardiol"},{"issue":"10","key":"10737_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139262","volume":"10","author":"M Matsukura","year":"2015","unstructured":"Matsukura M, Ozaki K, Takahashi A, Onouchi Y, Morizono T, Komai H, et al. Genome-wide association study of peripheral arterial disease in a japanese population. PLoS One. 2015;10(10):e0139262.","journal-title":"PLoS One"},{"issue":"8","key":"10737_CR7","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/s41591-019-0492-5","volume":"25","author":"D Klarin","year":"2019","unstructured":"Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, et al. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019;25(8):1274\u20139.","journal-title":"Nat Med"},{"issue":"5","key":"10737_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.119.002862","volume":"14","author":"NR van Zuydam","year":"2021","unstructured":"van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlstr\u00f6m EH, McLachlan S, et al. Genome-wide association study of peripheral artery disease. Circ Genom Precis Med. 2021;14(5):e002862.","journal-title":"Circ Genom Precis Med"},{"issue":"3","key":"10737_CR9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/1358863X211067564","volume":"27","author":"F Wang","year":"2022","unstructured":"Wang F, Ghanzouri I, Leeper NJ, Tsao PS, Ross EG. Development of a polygenic risk score to improve detection of peripheral artery disease. Vasc Med. 2022;27(3):219\u201327.","journal-title":"Vasc Med"},{"key":"10737_CR10","unstructured":"Forman R. Yale launches comprehensive DNA sequencing project, with aim of predicting, preventing, and treating gene-related diseases [Internet]. Yale School of Medicine; 2019 [cited 2024 Feb 22]. Available from: https:\/\/medicine.yale.edu\/news-article\/yale-launches-comprehensive-dna-sequencing-project-with-aim-of-predicting-preventing-and-treating-gene-related-diseases\/"},{"issue":"3","key":"10737_CR11","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.jvs.2012.01.073","volume":"56","author":"CIO Chaar","year":"2012","unstructured":"Chaar CIO, Makaroun MS, Marone LK, Rhee RY, Al-Khoury G, Cho JS, et al. Impact of endovascular options on lower extremity revascularization in young patients. J Vasc Surg. 2012;56(3):703-13.e1-3.","journal-title":"J Vasc Surg"},{"issue":"7","key":"10737_CR12","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1001\/jama.2019.22241","volume":"323","author":"J Elliott","year":"2020","unstructured":"Elliott J, Bodinier B, Bond TA, Chadeau-Hyam M, Evangelou E, Moons KGM, et al. Predictive accuracy of a polygenic risk score-enhanced prediction model vs a clinical risk score for coronary artery disease. JAMA. 2020;323(7):636\u201345.","journal-title":"JAMA"},{"issue":"14","key":"10737_CR13","doi-asserted-by":"publisher","first-page":"1129389","DOI":"10.3389\/fgene.2023.1129389","volume":"12","author":"AT DeWan","year":"2023","unstructured":"DeWan AT, Cahill ME, Cornejo-Sanchez DM, Li Y, Dong Z, Fabiha T, et al. Variants in JAZF1 are associated with asthma, type 2 diabetes, and height in the United Kingdom biobank population. Front Genet. 2023;12(14):1129389.","journal-title":"Front Genet"},{"issue":"3","key":"10737_CR14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559\u201375.","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10737_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson N, Price AL, Reich D. Population structure and eigenanalysis. PLoS Genet. 2006;2(12):e190.","journal-title":"PLoS Genet"},{"key":"10737_CR16","unstructured":"1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, et al. A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68\u201374."},{"issue":"7","key":"10737_CR17","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41588-021-00870-7","volume":"53","author":"J Mbatchou","year":"2021","unstructured":"Mbatchou J, Barnard L, Backman J, Marcketta A, Kosmicki JA, Ziyatdinov A, et al. Computationally efficient whole-genome regression for quantitative and binary traits. Nat Genet. 2021;53(7):1097\u2013103.","journal-title":"Nat Genet"},{"issue":"7","key":"10737_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009697","volume":"17","author":"G Zhou","year":"2021","unstructured":"Zhou G, Zhao H. A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics. PLoS Genet. 2021;17(7):e1009697.","journal-title":"PLoS Genet"},{"issue":"3","key":"10737_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.","journal-title":"PLoS Med"},{"issue":"10","key":"10737_CR20","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1038\/s41588-025-02342-8","volume":"57","author":"Z Yang","year":"2025","unstructured":"Yang Z, Pajuste F-D, Zguro K, Cheng Y, Kurant DE, Eoli A, et al. Limited overlap between genetic effects on disease susceptibility and disease survival. Nat Genet. 2025;57(10):2418\u201326.","journal-title":"Nat Genet"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10737-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-025-10737-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-025-10737-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:25:54Z","timestamp":1771615554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-025-10737-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10737"],"URL":"https:\/\/doi.org\/10.1007\/s12265-025-10737-5","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"23 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was conducted using the UK Biobank Resource (application number 32285) (19). The UK Biobank study was conducted under generic approval from the National Health Services\u2019 National Research Ethics Service. The present analyses were conducted in accordance with the Declaration of Helsinki and approved by the Human Investigations Committee at Yale University (2000026836 for UK Biobank and 2000024015 for Generations). The patients\/participants provided their written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All authors agree to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"14"}}