{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:41:10Z","timestamp":1793943670319,"version":"4.8.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s12265-026-10763-x","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:57:36Z","timestamp":1773075456000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biorefine, a Transcatheter Mitral Annulus Ablation System for the Treatment of Mitral Regurgitation: Pre-Clinical Study in Sheep"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-7024","authenticated-orcid":false,"given":"Avi","family":"Avner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leor","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"issue":"2","key":"10763_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jacc.2013.08.723","volume":"63","author":"SS Goel","year":"2014","unstructured":"Goel SS, Bajaj N, Aggarwal B, Gupta S, Poddar KL, Ige M, et al. Prevalence and outcomes of unoperated patients with severe symptomatic mitral regurgitation and heart failure: comprehensive analysis to determine the potential role of MitraClip for this unmet need. J Am Coll Cardiol. 2014;63(2):185\u20136. https:\/\/doi.org\/10.1016\/j.jacc.2013.08.723.","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"10763_CR2","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1161\/CIRCULATIONAHA.118.038207","volume":"139","author":"M Enriquez-Sarano","year":"2019","unstructured":"Enriquez-Sarano M, Michelena HI, Grigioni F. Treatment of functional mitral regurgitation. Circulation. 2019;139(20):2289\u201391. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.038207.","journal-title":"Circulation"},{"issue":"9540","key":"10763_CR3","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","volume":"368","author":"VT Nkomo","year":"2006","unstructured":"Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005\u201311. https:\/\/doi.org\/10.1016\/S0140-6736(06)69208-8.","journal-title":"Lancet"},{"key":"10763_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00152","volume":"6","author":"T Gasior","year":"2019","unstructured":"Gasior T, Gavazzoni M, Taramasso M, Zuber M, Maisano F. Direct percutaneous mitral annuloplasty in patients with functional mitral regurgitation: when and how. Front Cardiovasc Med. 2019;6:152. https:\/\/doi.org\/10.3389\/fcvm.2019.00152.","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10763_CR5","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJMoa1512913","volume":"374","author":"D Goldstein","year":"2016","unstructured":"Goldstein D, Moskowitz AJ, Gelijns AC, Ailawadi G, Parides MK, Perrault LP, et al. Cardiothoracic Surgical Trials Network Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation. N Engl J Med. 2016;374(4):344\u201353.","journal-title":"N Engl J Med"},{"issue":"10124","key":"10763_CR6","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/S0140-6736(18)30473-2","volume":"391","author":"V Dziadzko","year":"2018","unstructured":"Dziadzko V, Clavel MA, Dziadzko M, Medina-Inojosa JR, Michelena H, Maalouf J, et al. Outcome and undertreatment of mitral regurgitation: a community cohort study. Lancet. 2018;391(10124):960\u20139.","journal-title":"Lancet"},{"key":"10763_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01556-6","volume":"23","author":"JF Ooms","year":"2021","unstructured":"Ooms JF, Van Mieghem NM. Transcatheter repair and replacement technologies for mitral regurgitation: a European perspective. Curr Cardiol Rep. 2021;23:125.","journal-title":"Curr Cardiol Rep"},{"key":"10763_CR8","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20023","volume":"149","author":"F Praz","year":"2019","unstructured":"Praz F, Brugger N, Kassar M, Hunziker L, Moschovitis A, Stortecky S, et al. Interventional treatment of mitral valve regurgitation: an alternative to surgery? Swiss Med Wkly. 2019;149:w20023. https:\/\/doi.org\/10.4414\/smw.2019.20023.","journal-title":"Swiss Med Wkly"},{"key":"10763_CR9","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1161\/CIRCEP.113.001111","volume":"7","author":"VJHM van Driel","year":"2014","unstructured":"van Driel VJHM, Neven KGEJ, van Wessel H, du Pr\u00e9 BC, Vink A, Doevendans PAFM, et al. Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency. Circ Arrhythm Electrophysiol. 2014;7:734\u20138.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10763_CR10","first-page":"43","volume":"48","author":"R Goel","year":"2009","unstructured":"Goel R, Witzel T, Dickens D, Takeda PA, Heuser RR. The QuantumCor device for treating mitral regurgitation: an animal study. Catheter Cardiovasc Interv. 2009;48:43\u20138.","journal-title":"Catheter Cardiovasc Interv"},{"issue":"2","key":"10763_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.17691\/stm2025.17.2.02","volume":"17","author":"YL Rusakova","year":"2025","unstructured":"Rusakova YL, Zhuravleva IYu. Functional anatomy of the sheep heart as a model for testing cardiovascular devices. Sovrem Tehnol Med. 2025;17(2):13\u201322.","journal-title":"Sovrem Tehnol Med"},{"key":"10763_CR12","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s13239-020-00491-x","volume":"12","author":"A Avner","year":"2021","unstructured":"Avner A, Sabbag I, Raanani E. Transpericardial 3D echocardiography in the sheep model facilitating real-time anatomical assessment for planning and guiding transcatheter mitral valve replacement and repair. Cardiovasc Eng Technol. 2021;12:158\u201365.","journal-title":"Cardiovasc Eng Technol"},{"key":"10763_CR13","first-page":"135","volume":"10","author":"T Kuwahara","year":"2013","unstructured":"Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Nozato T, et al. Characteristics of lesion formation by radiofrequency ablation using different power settings. Heart Rhythm. 2013;10:135\u201341.","journal-title":"Heart Rhythm"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10763-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-026-10763-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10763-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:57:37Z","timestamp":1773075457000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-026-10763-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10763"],"URL":"https:\/\/doi.org\/10.1007\/s12265-026-10763-x","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"13 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving animals were conducted in accordance with institutional guidelines and approved by the Institutional Animal Care and Use Committee (IACUC) at the LRI preclinical research facility.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests relevant to the content of this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"38"}}