{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:57:03Z","timestamp":1785779823089,"version":"3.56.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["11000024T000002830987"],"award-info":[{"award-number":["11000024T000002830987"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s12265-026-10824-1","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:42:49Z","timestamp":1785778969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autoantibody-Based Models for the Diagnosis and Activity Assessment of Takayasu Arteritis"],"prefix":"10.1007","volume":"19","author":[{"given":"Jianxiong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-3630","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"1","key":"10824_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ajhg.2020.11.014","volume":"108","author":"L Ortiz-Fern\u00e1ndez","year":"2021","unstructured":"Ortiz-Fern\u00e1ndez L, et al. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study[J]. Am J Hum Genet. 2021;108(1):84\u201399.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10824_CR2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1136\/svn-2020-000809","volume":"7","author":"SS Ahn","year":"2022","unstructured":"Ahn SS, et al. Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea[J]. Stroke Vasc Neurol. 2022;7(2):149\u201357.","journal-title":"Stroke Vasc Neurol"},{"issue":"7","key":"10824_CR3","first-page":"e42667","volume":"15","author":"S Bhandari","year":"2023","unstructured":"Bhandari S, et al. Pathophysiology, Diagnosis, and Management of Takayasu Arteritis: A Review of Current Advances[J]. Cureus. 2023;15(7):e42667.","journal-title":"Cureus"},{"issue":"12","key":"10824_CR4","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1136\/ard-2022-223482","volume":"81","author":"PC Grayson","year":"2022","unstructured":"Grayson PC, et al. 2022 American College of Rheumatology\/EULAR classification criteria for Takayasu arteritis[J]. Ann Rheum Dis. 2022;81(12):1654\u201360.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10824_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13075-019-1813-2","volume":"21","author":"LY Ma","year":"2019","unstructured":"Ma LY, et al. Value of contrast-enhanced ultrasonography of the carotid artery for evaluating disease activity in Takayasu arteritis[J]. Arthritis Res Ther. 2019;21(1):24.","journal-title":"Arthritis Res Ther"},{"key":"10824_CR6","doi-asserted-by":"publisher","first-page":"723506","DOI":"10.3389\/fmed.2021.723506","volume":"8","author":"C Campochiaro","year":"2021","unstructured":"Campochiaro C, et al. A Prospective Observational Study on the Efficacy and Safety of Infliximab-Biosimilar (CT-P13) in Patients With Takayasu Arteritis (TAKASIM)[J]. Front Med (Lausanne). 2021;8:723506.","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"10824_CR7","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1212\/NXI.0000000000000204","volume":"3","author":"I Metz","year":"2016","unstructured":"Metz I, et al. Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis[J]. Neurol Neuroimmunol Neuroinflamm. 2016;3(2):e204.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10824_CR8","doi-asserted-by":"publisher","first-page":"e55053","DOI":"10.7554\/eLife.55053","volume":"9","author":"SE Vazquez","year":"2020","unstructured":"Vazquez SE, et al. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq[J]. Elife. 2020;9:e55053.","journal-title":"Elife"},{"key":"10824_CR9","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3389\/fimmu.2019.02023","volume":"10","author":"C Speake","year":"2019","unstructured":"Speake C, et al. Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study[J]. Front Immunol. 2019;10:2023.","journal-title":"Front Immunol"},{"issue":"5","key":"10824_CR10","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/s41591-022-01724-3","volume":"28","author":"K Sacco","year":"2022","unstructured":"Sacco K, et al. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19[J]. Nat Med. 2022;28(5):1050\u201362.","journal-title":"Nat Med"},{"issue":"5","key":"10824_CR11","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/s41416-024-02781-w","volume":"131","author":"T Li","year":"2024","unstructured":"Li T, et al. ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles[J]. Br J Cancer. 2024;131(5):883\u201394.","journal-title":"Br J Cancer"},{"issue":"1","key":"10824_CR12","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12935-023-03107-1","volume":"23","author":"T Li","year":"2023","unstructured":"Li T, et al. A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma[J]. Cancer Cell Int. 2023;23(1):273.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10824_CR13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00262-022-03242-0","volume":"72","author":"N Lou","year":"2023","unstructured":"Lou N, et al. Identification of novel serological autoantibodies in Chinese prostate cancer patients using high-throughput protein arrays[J]. Cancer Immunol Immunother. 2023;72(1):235\u201347.","journal-title":"Cancer Immunol Immunother"},{"key":"10824_CR14","doi-asserted-by":"publisher","first-page":"645632","DOI":"10.3389\/fimmu.2021.645632","volume":"12","author":"S Li","year":"2021","unstructured":"Li S, et al. Applications of Protein Microarrays in Biomarker Discovery for Autoimmune Diseases[J]. Front Immunol. 2021;12:645632.","journal-title":"Front Immunol"},{"key":"10824_CR15","doi-asserted-by":"crossref","unstructured":"Liu X et al. An autoantibody profile identified by human genome-wide protein arrays in rheumatoid arthritis[J]. MedComm (2020). 2024;5(8):e679.","DOI":"10.1002\/mco2.679"},{"issue":"8","key":"10824_CR16","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/art.1780330804","volume":"33","author":"JT Lie","year":"1990","unstructured":"Lie JT. Illustrated histopathologic classification criteria for selected vasculitis syndromes. American College of Rheumatology Subcommittee on Classification of Vasculitis[J]. Arthritis Rheum. 1990;33(8):1074\u201387.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10824_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/00002281-199401000-00006","volume":"6","author":"G Kerr","year":"1994","unstructured":"Kerr G. Takayasu\u2019s arteritis[J]. Curr Opin Rheumatol. 1994;6(1):32\u20138.","journal-title":"Curr Opin Rheumatol"},{"issue":"10","key":"10824_CR18","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1093\/rheumatology\/ket128","volume":"52","author":"R Misra","year":"2013","unstructured":"Misra R, et al. Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010)[J]. Rheumatology (Oxford). 2013;52(10):1795\u2013801.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10824_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1021\/pr800545q","volume":"8","author":"MK Tuck","year":"2009","unstructured":"Tuck MK, et al. Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group[J]. J Proteome Res. 2009;8(1):113\u20137.","journal-title":"J Proteome Res"},{"issue":"2","key":"10824_CR20","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1074\/mcp.M115.051250","volume":"15","author":"L Yang","year":"2016","unstructured":"Yang L, et al. Identification of Serum Biomarkers for Gastric Cancer Diagnosis Using a Human Proteome Microarray[J]. Mol Cell Proteom. 2016;15(2):614\u201323.","journal-title":"Mol Cell Proteom"},{"issue":"5","key":"10824_CR21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/1878-0261.13371","volume":"17","author":"Q Yang","year":"2023","unstructured":"Yang Q, et al. Human Proteome Microarray identifies autoantibodies to tumor-associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma[J]. Mol Oncol. 2023;17(5):887\u2013900.","journal-title":"Mol Oncol"},{"key":"10824_CR22","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.3389\/fimmu.2019.02845","volume":"10","author":"AYS Lee","year":"2019","unstructured":"Lee AYS, et al. Quantitative Mass Spectrometric Analysis of Autoantibodies as a Paradigm Shift in Autoimmune Serology[J]. Front Immunol. 2019;10:2845.","journal-title":"Front Immunol"},{"issue":"1","key":"10824_CR23","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/s41467-020-15088-0","volume":"11","author":"T Mutoh","year":"2020","unstructured":"Mutoh T, et al. Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis[J]. Nat Commun. 2020;11(1):1253.","journal-title":"Nat Commun"},{"key":"10824_CR24","doi-asserted-by":"publisher","first-page":"637871","DOI":"10.3389\/fonc.2021.637871","volume":"11","author":"C Cui","year":"2021","unstructured":"Cui C, et al. Identification of Novel Autoantibodies Based on the Human Proteomic Chips and Evaluation of Their Performance in the Detection of Gastric Cancer[J]. Front Oncol. 2021;11:637871.","journal-title":"Front Oncol"},{"issue":"2","key":"10824_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1136\/ard-2023-224816","volume":"83","author":"D Geetha","year":"2024","unstructured":"Geetha D, et al. Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial[J]. Ann Rheum Dis. 2024;83(2):223\u201332.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10824_CR26","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1002\/art.21921","volume":"54","author":"SK Chauhan","year":"2006","unstructured":"Chauhan SK, et al. Antigenic targets and pathogenicity of anti-aortic endothelial cell antibodies in Takayasu arteritis[J]. Arthritis Rheum. 2006;54(7):2326\u201333.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10824_CR27","first-page":"2023","volume":"30","author":"NK Tripathy","year":"2003","unstructured":"Tripathy NK, et al. Antimonocyte antibodies in Takayasu\u2019s arteritis: prevalence of and relation to disease activity[J]. J Rheumatol. 2003;30(9):2023\u20136.","journal-title":"J Rheumatol"},{"issue":"10","key":"10824_CR28","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s10067-014-2764-2","volume":"33","author":"K Gro\u00dfe","year":"2014","unstructured":"Gro\u00dfe K, et al. Association of ferritin antibodies with Takayasu arteritis[J]. Clin Rheumatol. 2014;33(10):1523\u20136.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"10824_CR29","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1046\/j.1365-2249.2003.02282.x","volume":"134","author":"NK Tripathy","year":"2003","unstructured":"Tripathy NK, et al. Anti-annexin V antibodies in Takayasu\u2019s arteritis: prevalence and relationship with disease activity[J]. Clin Exp Immunol. 2003;134(2):360\u20134.","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"10824_CR30","doi-asserted-by":"publisher","first-page":"e2013196","DOI":"10.1001\/jamanetworkopen.2020.13196","volume":"3","author":"J Vollert","year":"2020","unstructured":"Vollert J, et al. Assessment of Placebo Response in Objective and Subjective Outcome Measures in Rheumatoid Arthritis Clinical Trials[J]. JAMA Netw Open. 2020;3(9):e2013196.","journal-title":"JAMA Netw Open"},{"issue":"6","key":"10824_CR31","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1080\/14397595.2021.1879347","volume":"31","author":"C Rongyi","year":"2021","unstructured":"Rongyi C, et al. Effect of hydroxychloroquine on angiographic progression in routine treatment of Takayasu arteritis[J]. Mod Rheumatol. 2021;31(6):1135\u201341.","journal-title":"Mod Rheumatol"},{"issue":"7","key":"10824_CR32","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.autrev.2018.01.016","volume":"17","author":"A Casian","year":"2018","unstructured":"Casian A, et al. New use for an old treatment: Hydroxychloroquine as a potential treatment for systemic vasculitis[J]. Autoimmun Rev. 2018;17(7):660\u20134.","journal-title":"Autoimmun Rev"},{"issue":"10","key":"10824_CR33","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1136\/annrheumdis-2019-215567","volume":"78","author":"X Kong","year":"2019","unstructured":"Kong X, et al. Takayasu arteritis risk locus in IL6 represses the anti-inflammatory gene GPNMB through chromatin looping and recruiting MEF2-HDAC complex[J]. Ann Rheum Dis. 2019;78(10):1388\u201397.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10824_CR34","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1021\/acs.analchem.8b05688","volume":"91","author":"J Ma","year":"2019","unstructured":"Ma J, et al. O-GlcNAc Site Mapping by Using a Combination of Chemoenzymatic Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry[J]. Anal Chem. 2019;91(4):2620\u20135.","journal-title":"Anal Chem"},{"issue":"4","key":"10824_CR35","doi-asserted-by":"publisher","first-page":"e152297","DOI":"10.1172\/JCI152297","volume":"132","author":"H Yin","year":"2022","unstructured":"Yin H, et al. Table 2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis[J]. J Clin Invest. 2022;132(4):e152297.","journal-title":"J Clin Invest"},{"issue":"25","key":"10824_CR36","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1182\/blood.2023020973","volume":"143","author":"J Kath","year":"2024","unstructured":"Kath J, et al. Integration of \u03b6-deficient CARs into the CD3\u03b6 gene conveys potent cytotoxicity in T and NK cells[J]. Blood. 2024;143(25):2599\u2013611.","journal-title":"Blood"},{"issue":"1","key":"10824_CR37","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1038\/s41467-022-29668-9","volume":"13","author":"M Sugita","year":"2022","unstructured":"Sugita M, et al. Allogeneic TCR\u03b1\u03b2 deficient CAR T-cells targeting CD123 in acute myeloid leukemia[J]. Nat Commun. 2022;13(1):2227.","journal-title":"Nat Commun"},{"issue":"12","key":"10824_CR38","doi-asserted-by":"publisher","first-page":"e150927","DOI":"10.1172\/JCI150927","volume":"132","author":"GK Dwyer","year":"2022","unstructured":"Dwyer GK, et al. IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease[J]. J Clin Invest. 2022;132(12):e150927.","journal-title":"J Clin Invest"},{"issue":"6","key":"10824_CR39","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/art.41635","volume":"73","author":"M Wang","year":"2021","unstructured":"Wang M, et al. Association of the Leukocyte Immunoglobulin-like Receptor A3 Gene With Neutrophil Activation and Disease Susceptibility in Adult-Onset Still\u2019s Disease[J]. Arthritis Rheumatol. 2021;73(6):1033\u201343.","journal-title":"Arthritis Rheumatol"},{"issue":"51","key":"10824_CR40","doi-asserted-by":"publisher","first-page":"13045","DOI":"10.1073\/pnas.1808850115","volume":"115","author":"C Terao","year":"2018","unstructured":"Terao C, et al. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis[J]. Proc Natl Acad Sci U S A. 2018;115(51):13045\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10824_CR41","doi-asserted-by":"publisher","first-page":"882","DOI":"10.4143\/crt.2021.642","volume":"54","author":"J Suh","year":"2022","unstructured":"Suh J, et al. Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis[J]. Cancer Res Treat. 2022;54(3):882\u201393.","journal-title":"Cancer Res Treat"},{"key":"10824_CR42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ebiom.2018.06.015","volume":"33","author":"M Salter","year":"2018","unstructured":"Salter M, et al. Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis[J]. EBioMedicine. 2018;33:169\u201384.","journal-title":"EBioMedicine"},{"issue":"6","key":"10824_CR43","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s12250-018-0069-3","volume":"33","author":"R Han","year":"2018","unstructured":"Han R, et al. Influence of Human Papillomavirus E7 Oncoprotein on Maturation and Function of Plasmacytoid Dendritic Cells In Vitro[J]. Virol Sin. 2018;33(6):493\u2013501.","journal-title":"Virol Sin"},{"issue":"9","key":"10824_CR44","doi-asserted-by":"publisher","first-page":"e632","DOI":"10.1016\/S2589-7500(22)00112-1","volume":"4","author":"SK Byeon","year":"2022","unstructured":"Byeon SK, et al. Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study[J]. Lancet Digit Health. 2022;4(9):e632\u201345.","journal-title":"Lancet Digit Health"},{"key":"10824_CR45","doi-asserted-by":"publisher","first-page":"709173","DOI":"10.3389\/fimmu.2021.709173","volume":"12","author":"A Derakhshani","year":"2021","unstructured":"Derakhshani A, et al. The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters[J]. Front Immunol. 2021;12:709173.","journal-title":"Front Immunol"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10824-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-026-10824-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10824-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:42:50Z","timestamp":1785778970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-026-10824-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10824"],"URL":"https:\/\/doi.org\/10.1007\/s12265-026-10824-1","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"5 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Medical Ethics Committee of the Beijing Anzhen Hospita (2018002X). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation, and with the Helsinki Declaration of 1975, as revised in 2000 (5). No animal studies were carried out by the authors for this article. All individuals included signed the informed consent before study participation.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"96"}}