{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:09:59Z","timestamp":1788898199293,"version":"build-2803163510"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Transl. Res."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s12265-026-10843-y","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:19:47Z","timestamp":1788891587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Collagen Prolyl 4-Hydroxylase: An Emerging Key Player in Cardiac Fibrosis"],"prefix":"10.1007","volume":"19","author":[{"given":"Wei","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zai-Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-4501","authenticated-orcid":false,"given":"Li-Huang","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"10843_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2024.08.008","volume":"134","author":"IG Lunde","year":"2024","unstructured":"Lunde IG, Rypdal KB, Van Linthout S, Diez J, Gonz\u00e1lez A. Myocardial fibrosis from the perspective of the extracellular matrix: Mechanisms to clinical impact. Matrix Biol. 2024;134:1\u201322.","journal-title":"Matrix Biol"},{"issue":"4","key":"10843_CR2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","volume":"71","author":"P Kong","year":"2014","unstructured":"Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci. 2014;71(4):549\u201374.","journal-title":"Cell Mol Life Sci"},{"key":"10843_CR3","doi-asserted-by":"publisher","first-page":"110066","DOI":"10.1016\/j.cellsig.2021.110066","volume":"85","author":"MP Czubryt","year":"2021","unstructured":"Czubryt MP, Hale TM. Cardiac fibrosis: Pathobiology and therapeutic targets. Cell Signal. 2021;85:110066.","journal-title":"Cell Signal"},{"issue":"6","key":"10843_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.tcm.2019.09.003","volume":"30","author":"TR Eijgenraam","year":"2020","unstructured":"Eijgenraam TR, Sillj\u00e9 HHW, de Boer RA. Current understanding of fibrosis in genetic cardiomyopathies. Trends Cardiovasc Med. 2020;30(6):353\u201361.","journal-title":"Trends Cardiovasc Med"},{"issue":"12","key":"10843_CR5","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1161\/CIRCRESAHA.124.323658","volume":"134","author":"I Hilgendorf","year":"2024","unstructured":"Hilgendorf I, Frantz S, Frangogiannis NG. Repair of the Infarcted Heart: Cellular Effectors, Molecular Mechanisms and Therapeutic Opportunities. Circ Res. 2024;134(12):1718\u201351.","journal-title":"Circ Res"},{"issue":"15","key":"10843_CR6","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","volume":"71","author":"A Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez A, Schelbert EB, D\u00edez J, Butler J. Myocardial Interstitial Fibrosis in Heart Failure: Biological and Translational Perspectives. J Am Coll Cardiol. 2018;71(15):1696\u2013706.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10843_CR7","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1161\/01.RES.62.4.757","volume":"62","author":"KT Weber","year":"1988","unstructured":"Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res. 1988;62(4):757\u201365.","journal-title":"Circ Res"},{"issue":"11","key":"10843_CR8","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.jacc.2013.10.084","volume":"63","author":"AH Ellims","year":"2014","unstructured":"Ellims AH, Shaw JA, Stub D, Iles LM, Hare JL, Slavin GS, et al. Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness. J Am Coll Cardiol. 2014;63(11):1112\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10843_CR9","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/j.2040-4603.2017.tb00771.x","volume":"7","author":"MN Nguyen","year":"2017","unstructured":"Nguyen MN, Kiriazis H, Gao XM, Du XJ. Cardiac Fibrosis and Arrhythmogenesis. Compr Physiol. 2017;7(3):1009\u201349.","journal-title":"Compr Physiol"},{"key":"10843_CR10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","volume":"173","author":"M Liu","year":"2021","unstructured":"Liu M, L\u00f3pez de Juan Abad B, Cheng K. Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies. Adv Drug Deliv Rev. 2021;173:504\u201319.","journal-title":"Adv Drug Deliv Rev"},{"key":"10843_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev-physiol-021119-034527","volume":"82","author":"MD Tallquist","year":"2020","unstructured":"Tallquist MD. Cardiac Fibroblast Diversity. Annu Rev Physiol. 2020;82:63\u201378.","journal-title":"Annu Rev Physiol"},{"issue":"10","key":"10843_CR12","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1172\/JCI94753","volume":"127","author":"H Khalil","year":"2017","unstructured":"Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, et al. Fibroblast-specific TGF-\u03b2-Smad2\/3 signaling underlies cardiac fibrosis. J Clin Invest. 2017;127(10):3770\u201383.","journal-title":"J Clin Invest"},{"issue":"12","key":"10843_CR13","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.1002\/jcp.29732","volume":"235","author":"Y Liu","year":"2020","unstructured":"Liu Y, Xu J, Wu M, Kang L, Xu B. The effector cells and cellular mediators of immune system involved in cardiac inflammation and fibrosis after myocardial infarction. J Cell Physiol. 2020;235(12):8996\u20139004.","journal-title":"J Cell Physiol"},{"key":"10843_CR14","doi-asserted-by":"crossref","unstructured":"Adapala RK, Katari V, Teegala LR, Thodeti S, Paruchuri S, Thodeti CK. TRPV4 Mechanotransduction in fibrosis. Cells. 2021;10(11).","DOI":"10.3390\/cells10113053"},{"issue":"2","key":"10843_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3109\/10409231003627991","volume":"45","author":"KL Gorres","year":"2010","unstructured":"Gorres KL, Raines RT. Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol. 2010;45(2):106\u201324.","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"1","key":"10843_CR16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/exd.14197","volume":"30","author":"AM Salo","year":"2021","unstructured":"Salo AM, Myllyharju J. Prolyl and lysyl hydroxylases in collagen synthesis. Exp Dermatol. 2021;30(1):38\u201349.","journal-title":"Exp Dermatol"},{"issue":"12","key":"10843_CR17","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.str.2013.09.005","volume":"21","author":"J Anantharajan","year":"2013","unstructured":"Anantharajan J, Koski MK, Kursula P, Hieta R, Bergmann U, Myllyharju J, et al. The structural motifs for substrate binding and dimerization of the \u03b1 subunit of collagen prolyl 4-hydroxylase. Structure. 2013;21(12):2107\u201318.","journal-title":"Structure"},{"key":"10843_CR18","doi-asserted-by":"crossref","unstructured":"Joshi A, Mondal B, Basak T. Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation. Biochem J. 2026;483(2).","DOI":"10.1042\/BCJ20253467"},{"key":"10843_CR19","doi-asserted-by":"crossref","unstructured":"Kurose H. Cardiac fibrosis and fibroblasts. Cells. 2021;10(7).","DOI":"10.3390\/cells10071716"},{"key":"10843_CR20","doi-asserted-by":"publisher","first-page":"1493420","DOI":"10.3389\/fphar.2024.1493420","volume":"15","author":"X Yang","year":"2024","unstructured":"Yang X, Zhang D, Li M, Shao Y, Zhang X, Xue Y. P4HA1: an important target for treating fibrosis related diseases and cancer. Front Pharmacol. 2024;15:1493420.","journal-title":"Front Pharmacol"},{"key":"10843_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/ijms26199371","volume":"26","author":"D Hironaka","year":"2025","unstructured":"Hironaka D, Xiong G. Enhanced Collagen Prolyl 4-Hydroxylase Activity and Expression Promote Cancer Progression via Both Canonical and Non-Canonical Mechanisms. Int J Mol Sci. 2025;26:19.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10843_CR22","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/abbs\/gmab065","volume":"53","author":"R Shi","year":"2021","unstructured":"Shi R, Gao S, Zhang J, Xu J, Graham LM, Yang X, et al. Collagen prolyl 4-hydroxylases modify tumor progression. Acta Biochim Biophys Sin (Shanghai). 2021;53(7):805\u201314.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"10843_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12032-025-03219-w","volume":"43","author":"R Shi","year":"2025","unstructured":"Shi R, Liu Y, Yu R. Targeting collagen Prolyl 4-hydroxylase for cancer treatment. Med Oncol. 2025;43(2):99.","journal-title":"Med Oncol"},{"issue":"6","key":"10843_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1080\/07853890801986594","volume":"40","author":"J Myllyharju","year":"2008","unstructured":"Myllyharju J. Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med. 2008;40(6):402\u201317.","journal-title":"Ann Med"},{"issue":"5","key":"10843_CR25","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1096\/fasebj.3.5.2537773","volume":"3","author":"KI Kivirikko","year":"1989","unstructured":"Kivirikko KI, Myllyl\u00e4 R, Pihlajaniemi T. Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit. Faseb j. 1989;3(5):1609\u201317.","journal-title":"Faseb j"},{"issue":"1","key":"10843_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0945-053X(03)00006-4","volume":"22","author":"J Myllyharju","year":"2003","unstructured":"Myllyharju J. Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003;22(1):15\u201324.","journal-title":"Matrix Biol"},{"issue":"8","key":"10843_CR27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0968-0004(94)90072-8","volume":"19","author":"RB Freedman","year":"1994","unstructured":"Freedman RB, Hirst TR, Tuite MF. Protein disulphide isomerase: building bridges in protein folding. Trends Biochem Sci. 1994;19(8):331\u20136.","journal-title":"Trends Biochem Sci"},{"issue":"12","key":"10843_CR28","doi-asserted-by":"publisher","first-page":"102614","DOI":"10.1016\/j.jbc.2022.102614","volume":"298","author":"AV Murthy","year":"2022","unstructured":"Murthy AV, Sulu R, Lebedev A, Salo AM, Korhonen K, Venkatesan R, et al. Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H \u03b1(2)\u03b2(2) tetramer. J Biol Chem. 2022;298(12):102614.","journal-title":"J Biol Chem"},{"issue":"1","key":"10843_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.embor.7400311","volume":"6","author":"L Ellgaard","year":"2005","unstructured":"Ellgaard L, Ruddock LW. The human protein disulphide isomerase family: substrate interactions and functional properties. EMBO Rep. 2005;6(1):28\u201332.","journal-title":"EMBO Rep"},{"issue":"Suppl 3","key":"10843_CR30","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/0168-8278(91)90002-S","volume":"13","author":"T Pihlajaniemi","year":"1991","unstructured":"Pihlajaniemi T, Myllyl\u00e4 R, Kivirikko KI. Prolyl 4-hydroxylase and its role in collagen synthesis. J Hepatol. 1991;13(Suppl 3):S2\u20137.","journal-title":"J Hepatol"},{"issue":"26","key":"10843_CR31","doi-asserted-by":"publisher","first-page":"22905","DOI":"10.1074\/jbc.M110.199984","volume":"286","author":"MD Shoulders","year":"2011","unstructured":"Shoulders MD, Raines RT. Interstrand dipole-dipole interactions can stabilize the collagen triple helix. J Biol Chem. 2011;286(26):22905\u201312.","journal-title":"J Biol Chem"},{"key":"10843_CR32","doi-asserted-by":"publisher","first-page":"12556","DOI":"10.1038\/srep12556","volume":"5","author":"WY Chow","year":"2015","unstructured":"Chow WY, Bihan D, Forman CJ, Slatter DA, Reid DG, Wales DJ, et al. Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix. Sci Rep. 2015;5:12556.","journal-title":"Sci Rep"},{"issue":"10","key":"10843_CR33","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1073\/pnas.92.10.4427","volume":"92","author":"T Helaakoski","year":"1995","unstructured":"Helaakoski T, Annunen P, Vuori K, MacNeil IA, Pihlajaniemi T, Kivirikko KI. Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase\/beta subunit. Proc Natl Acad Sci U S A. 1995;92(10):4427\u201331.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"27","key":"10843_CR34","doi-asserted-by":"publisher","first-page":"16964","DOI":"10.1074\/jbc.M115.662635","volume":"290","author":"E Aro","year":"2015","unstructured":"Aro E, Salo AM, Khatri R, Finnil\u00e4 M, Miinalainen I, Sormunen R, et al. Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I. J Biol Chem. 2015;290(27):16964\u201378.","journal-title":"J Biol Chem"},{"issue":"9","key":"10843_CR35","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1177\/002215540104900908","volume":"49","author":"R Nissi","year":"2001","unstructured":"Nissi R, Autio-Harmainen H, Marttila P, Sormunen R, Kivirikko KI. Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several human tissues. J Histochem Cytochem. 2001;49(9):1143\u201353.","journal-title":"J Histochem Cytochem"},{"issue":"5","key":"10843_CR36","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/01.CIR.0000080883.53863.5C","volume":"108","author":"C Van Den Diepstraten","year":"2003","unstructured":"Van Den Diepstraten C, Papay K, Bolender Z, Brown A, Pickering JG. Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque. Circulation. 2003;108(5):508\u201311.","journal-title":"Circulation"},{"issue":"48","key":"10843_CR37","doi-asserted-by":"publisher","first-page":"47685","DOI":"10.1074\/jbc.M306806200","volume":"278","author":"L Kukkola","year":"2003","unstructured":"Kukkola L, Hieta R, Kivirikko KI, Myllyharju J. Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem. 2003;278(48):47685\u201393.","journal-title":"J Biol Chem"},{"key":"10843_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.matbio.2023.12.001","volume":"125","author":"AM Salo","year":"2024","unstructured":"Salo AM, Rappu P, Koski MK, Karjalainen E, Izzi V, Drushinin K, et al. Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets. Matrix Biol. 2024;125:73\u201387.","journal-title":"Matrix Biol"},{"issue":"37","key":"10843_CR39","doi-asserted-by":"publisher","first-page":"34966","DOI":"10.1074\/jbc.M303624200","volume":"278","author":"R Hieta","year":"2003","unstructured":"Hieta R, Kukkola L, Permi P, Piril\u00e4 P, Kivirikko KI, Kilpel\u00e4inen I, et al. The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides. J Biol Chem. 2003;278(37):34966\u201374.","journal-title":"J Biol Chem"},{"key":"10843_CR40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/978-3-030-80614-9_2","volume":"1348","author":"MJ Mienaltowski","year":"2021","unstructured":"Mienaltowski MJ, Haddox NL, Beall JM, Pechanec MY. Basic Structure, Physiology, and Biochemistry of Connective Tissues and Extracellular Matrix Collagens. Adv Exp Med Biol. 2021;1348:5\u201343.","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10843_CR41","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1600-0625.2011.01313.x","volume":"20","author":"T Krieg","year":"2011","unstructured":"Krieg T, Aumailley M. The extracellular matrix of the dermis: flexible structures with dynamic functions. Exp Dermatol. 2011;20(8):689\u201395.","journal-title":"Exp Dermatol"},{"issue":"6","key":"10843_CR42","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1074\/jbc.TM118.002812","volume":"294","author":"S Ito","year":"2019","unstructured":"Ito S, Nagata K. Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease. J Biol Chem. 2019;294(6):2133\u201341.","journal-title":"J Biol Chem"},{"issue":"1","key":"10843_CR43","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/0005-2795(73)90164-5","volume":"303","author":"S Sakakibara","year":"1973","unstructured":"Sakakibara S, Inouye K, Shudo K, Kishida Y, Kobayashi Y, Prockop DJ. Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline. Biochim Biophys Acta. 1973;303(1):198\u2013202.","journal-title":"Biochim Biophys Acta"},{"issue":"21","key":"10843_CR44","doi-asserted-by":"publisher","first-page":"14884","DOI":"10.1074\/jbc.274.21.14884","volume":"274","author":"AR Walmsley","year":"1999","unstructured":"Walmsley AR, Batten MR, Lad U, Bulleid NJ. Intracellular retention of procollagen within the endoplasmic reticulum is mediated by prolyl 4-hydroxylase. J Biol Chem. 1999;274(21):14884\u201392.","journal-title":"J Biol Chem"},{"issue":"3","key":"10843_CR45","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1042\/EBC20180053","volume":"63","author":"P Rappu","year":"2019","unstructured":"Rappu P, Salo AM, Myllyharju J, Heino J. Role of prolyl hydroxylation in the molecular interactions of collagens. Essays Biochem. 2019;63(3):325\u201335.","journal-title":"Essays Biochem"},{"issue":"4","key":"10843_CR46","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1074\/jbc.M606608200","volume":"282","author":"T Holster","year":"2007","unstructured":"Holster T, Pakkanen O, Soininen R, Sormunen R, Nokelainen M, Kivirikko KI, et al. Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. J Biol Chem. 2007;282(4):2512\u20139.","journal-title":"J Biol Chem"},{"key":"10843_CR47","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.matbio.2015.04.001","volume":"44\u201346","author":"M Bekhouche","year":"2015","unstructured":"Bekhouche M, Colige A. The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology. Matrix Biol. 2015;44\u201346:46\u201353.","journal-title":"Matrix Biol"},{"issue":"13","key":"10843_CR48","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.1128\/MCB.23.13.4428-4438.2003","volume":"23","author":"WN Pappano","year":"2003","unstructured":"Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS. Use of Bmp1\/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1\/tolloid-like metalloproteinases. Mol Cell Biol. 2003;23(13):4428\u201338.","journal-title":"Mol Cell Biol"},{"issue":"17","key":"10843_CR49","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.jacc.2020.03.019","volume":"75","author":"J D\u00edez","year":"2020","unstructured":"D\u00edez J, Gonz\u00e1lez A, Kovacic JC. Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3\/4: JACC Focus Seminar. J Am Coll Cardiol. 2020;75(17):2204\u201318.","journal-title":"J Am Coll Cardiol"},{"key":"10843_CR50","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.matbio.2015.03.005","volume":"44\u201346","author":"V Arpino","year":"2015","unstructured":"Arpino V, Brock M, Gill SE. The role of TIMPs in regulation of extracellular matrix proteolysis. Matrix Biol. 2015;44\u201346:247\u201354.","journal-title":"Matrix Biol"},{"key":"10843_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","volume":"147","author":"N Cui","year":"2017","unstructured":"Cui N, Hu M, Khalil RA. Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog Mol Biol Transl Sci. 2017;147:1\u201373.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"3","key":"10843_CR52","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1165\/rcmb.2012-0050OC","volume":"47","author":"X Huang","year":"2012","unstructured":"Huang X, Yang N, Fiore VF, Barker TH, Sun Y, Morris SW, et al. Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol. 2012;47(3):340\u20138.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10843_CR53","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.matbio.2008.01.004","volume":"27","author":"L Kennedy","year":"2008","unstructured":"Kennedy L, Shi-Wen X, Carter DE, Abraham DJ, Leask A. Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol. 2008;27(4):274\u201381.","journal-title":"Matrix Biol"},{"issue":"20","key":"10843_CR54","doi-asserted-by":"publisher","first-page":"10832","DOI":"10.1073\/pnas.1910650117","volume":"117","author":"L Liu","year":"2020","unstructured":"Liu L, Yu H, Zhao H, Wu Z, Long Y, Zhang J, et al. Matrix-transmitted paratensile signaling enables myofibroblast-fibroblast cross talk in fibrosis expansion. Proc Natl Acad Sci U S A. 2020;117(20):10832\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10843_CR55","doi-asserted-by":"publisher","first-page":"e39969","DOI":"10.1371\/journal.pone.0039969","volume":"7","author":"H Wang","year":"2012","unstructured":"Wang H, Haeger SM, Kloxin AM, Leinwand LA, Anseth KS. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS ONE. 2012;7(7):e39969.","journal-title":"PLoS ONE"},{"issue":"4","key":"10843_CR56","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1039\/c2ib00149g","volume":"4","author":"JL Balestrini","year":"2012","unstructured":"Balestrini JL, Chaudhry S, Sarrazy V, Koehler A, Hinz B. The mechanical memory of lung myofibroblasts. Integr Biol (Camb). 2012;4(4):410\u201321.","journal-title":"Integr Biol (Camb)"},{"issue":"4","key":"10843_CR57","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1083\/jcb.201004082","volume":"190","author":"F Liu","year":"2010","unstructured":"Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010;190(4):693\u2013706.","journal-title":"J Cell Biol"},{"issue":"4","key":"10843_CR58","doi-asserted-by":"publisher","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","volume":"308","author":"F Liu","year":"2015","unstructured":"Liu F, Lagares D, Choi KM, Stopfer L, Marinkovi\u0107 A, Vrbanac V, et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015;308(4):L344\u201357.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"10843_CR59","first-page":"e9349","volume":"12","author":"MA Khan","year":"2020","unstructured":"Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi S, AlKatheeri R, et al. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020;12(7):e9349.","journal-title":"Cureus"},{"issue":"4","key":"10843_CR60","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/j.2040-4603.2015.tb00664.x","volume":"5","author":"NG Frangogiannis","year":"2015","unstructured":"Frangogiannis NG. Pathophysiology of Myocardial Infarction. Compr Physiol. 2015;5(4):1841\u201375.","journal-title":"Compr Physiol"},{"issue":"10065","key":"10843_CR61","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","volume":"389","author":"GW Reed","year":"2017","unstructured":"Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017;389(10065):197\u2013210.","journal-title":"Lancet"},{"issue":"1","key":"10843_CR62","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","author":"SD Prabhu","year":"2016","unstructured":"Prabhu SD, Frangogiannis NG. The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res. 2016;119(1):91\u2013112.","journal-title":"Circ Res"},{"key":"10843_CR63","doi-asserted-by":"publisher","first-page":"599511","DOI":"10.3389\/fimmu.2020.599511","volume":"11","author":"MJM Silvis","year":"2020","unstructured":"Silvis MJM, Kaffka Genaamd Dengler SE, Odille CA, Mishra M, van der Kaaij NP, Doevendans PA, et al. Damage-Associated Molecular Patterns in Myocardial Infarction and Heart Transplantation: The Road to Translational Success. Front Immunol. 2020;11:599511.","journal-title":"Front Immunol"},{"issue":"5","key":"10843_CR64","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1172\/JCI87491","volume":"127","author":"NG Frangogiannis","year":"2017","unstructured":"Frangogiannis NG. The extracellular matrix in myocardial injury, repair, and remodeling. J Clin Invest. 2017;127(5):1600\u201312.","journal-title":"J Clin Invest"},{"issue":"17","key":"10843_CR65","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1016\/j.jacc.2020.03.020","volume":"75","author":"NG Frangogiannis","year":"2020","unstructured":"Frangogiannis NG, Kovacic JC. Extracellular Matrix in Ischemic Heart Disease, Part 4\/4: JACC Focus Seminar. J Am Coll Cardiol. 2020;75(17):2219\u201335.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10843_CR66","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","volume":"365","author":"V Talman","year":"2016","unstructured":"Talman V, Ruskoaho H. Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration. Cell Tissue Res. 2016;365(3):563\u201381.","journal-title":"Cell Tissue Res"},{"issue":"8","key":"10843_CR67","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1006\/jmcc.1997.0462","volume":"29","author":"A Agocha","year":"1997","unstructured":"Agocha A, Lee HW, Eghbali-Webb M. Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: effects of transforming growth factor-beta1, thyroid hormone, angiotensin II and basic fibroblast growth factor. J Mol Cell Cardiol. 1997;29(8):2233\u201344.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10843_CR68","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/cbir.1997.0130","volume":"21","author":"M Tamamori","year":"1997","unstructured":"Tamamori M, Ito H, Hiroe M, Marumo F, Hata RI. Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides. Cell Biol Int. 1997;21(3):175\u201380.","journal-title":"Cell Biol Int"},{"issue":"1","key":"10843_CR69","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12967-024-04872-x","volume":"22","author":"Y Xu","year":"2024","unstructured":"Xu Y, Xia D, Huang K, Liang M. Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1. J Transl Med. 2024;22(1):74.","journal-title":"J Transl Med"},{"issue":"8","key":"10843_CR70","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0022-2828(95)90095-0","volume":"27","author":"EG Eleftheriades","year":"1995","unstructured":"Eleftheriades EG, Ferguson AG, Spragia ML, Samarel AM. Prolyl hydroxylation regulates intracellular procollagen degradation in cultured rat cardiac fibroblasts. J Mol Cell Cardiol. 1995;27(8):1459\u201373.","journal-title":"J Mol Cell Cardiol"},{"key":"10843_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2017.09.005","volume":"113","author":"RT Cowling","year":"2017","unstructured":"Cowling RT, Park JI, Sotimehin AE, Greenberg BH. Ascorbate starvation alters endoplasmic reticulum-resident enzymes in cardiac fibroblasts, priming them for increased procollagen secretion. J Mol Cell Cardiol. 2017;113:1\u20138.","journal-title":"J Mol Cell Cardiol"},{"issue":"17","key":"10843_CR72","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1007\/s00018-019-03081-w","volume":"76","author":"R Shi","year":"2019","unstructured":"Shi R, Hu W, Zhang Y, Gao S, Smith AH, Ye J, et al. Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit \u03b11 promote hydroxylation and secretion of type I collagen. Cell Mol Life Sci. 2019;76(17):3449\u201364.","journal-title":"Cell Mol Life Sci"},{"issue":"Suppl 1","key":"10843_CR73","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.21037\/jtd.2016.11.19","volume":"9","author":"NG Frangogiannis","year":"2017","unstructured":"Frangogiannis NG. The role of transforming growth factor (TGF)-\u03b2 in the infarcted myocardium. J Thorac Dis. 2017;9(Suppl 1):S52\u201363.","journal-title":"J Thorac Dis"},{"issue":"16","key":"10843_CR74","doi-asserted-by":"publisher","first-page":"10849","DOI":"10.1074\/jbc.M511237200","volume":"281","author":"L Chen","year":"2006","unstructured":"Chen L, Shen YH, Wang X, Wang J, Gan Y, Chen N, et al. Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. J Biol Chem. 2006;281(16):10849\u201355.","journal-title":"J Biol Chem"},{"issue":"2","key":"10843_CR75","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.bbrc.2004.08.129","volume":"323","author":"M Raveendran","year":"2004","unstructured":"Raveendran M, Senthil D, Utama B, Shen Y, Dudley D, Wang J, et al. Cigarette suppresses the expression of P4Halpha and vascular collagen production. Biochem Biophys Res Commun. 2004;323(2):592\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10843_CR76","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1016\/j.apsb.2025.07.011","volume":"15","author":"X Yang","year":"2025","unstructured":"Yang X, Zhang Y, Leng X, Wang Y, Gong M, Liu D, et al. Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis. Acta Pharm Sin B. 2025;15(9):4789\u2013806.","journal-title":"Acta Pharm Sin B"},{"key":"10843_CR77","doi-asserted-by":"crossref","unstructured":"Zhang Y, Wang S, Liu J, Du Z, Yin C, Fan S et al. Sarm1-containing extrachromosomal circular DNA promotes aging-associated cardiac fibrosis via TGF-\u03b2\/Smad activation. J Mol Cell Biol. 2026.","DOI":"10.1093\/jmcb\/mjag005"},{"issue":"8","key":"10843_CR78","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/ATVBAHA.107.144881","volume":"27","author":"C Zhang","year":"2007","unstructured":"Zhang C, Zhang MX, Shen YH, Burks JK, Zhang Y, Wang J, et al. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol. 2007;27(8):1760\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"18","key":"10843_CR79","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1161\/hc4301.097193","volume":"104","author":"JI Nwogu","year":"2001","unstructured":"Nwogu JI, Geenen D, Bean M, Brenner MC, Huang X, Buttrick PM. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation. 2001;104(18):2216\u201321.","journal-title":"Circulation"},{"issue":"9","key":"10843_CR80","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.amjmed.2008.03.046","volume":"121","author":"A Aneja","year":"2008","unstructured":"Aneja A, Tang WH, Bansilal S, Garcia MJ, Farkouh ME. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am J Med. 2008;121(9):748\u201357.","journal-title":"Am J Med"},{"key":"10843_CR81","doi-asserted-by":"crossref","unstructured":"Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K et al. Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus. Int J Mol Sci. 2022;23(7).","DOI":"10.3390\/ijms23073587"},{"key":"10843_CR82","first-page":"1514","volume":"9","author":"G Borghetti","year":"2018","unstructured":"Borghetti G, von Lewinski D, Eaton DM, Sourij H, Houser SR, Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control Front Physiol. 2018;9:1514.","journal-title":"Beyond Glycemic Control Front Physiol"},{"issue":"2","key":"10843_CR83","doi-asserted-by":"publisher","first-page":"7","DOI":"10.17925\/HI.2024.18.2.2","volume":"18","author":"AJ Binu","year":"2024","unstructured":"Binu AJ, Kapoor N. Understanding Diabetic Cardiomyopathy: Insulin Resistance and Beyond. Heart Int. 2024;18(2):7\u201313.","journal-title":"Heart Int"},{"key":"10843_CR84","doi-asserted-by":"publisher","first-page":"113904","DOI":"10.1016\/j.addr.2021.113904","volume":"176","author":"I Tuleta","year":"2021","unstructured":"Tuleta I, Frangogiannis NG. Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities. Adv Drug Deliv Rev. 2021;176:113904.","journal-title":"Adv Drug Deliv Rev"},{"key":"10843_CR85","doi-asserted-by":"crossref","unstructured":"Pan KL, Hsu YC, Chang ST, Chung CM, Lin CL. The Role of cardiac fibrosis in diabetic cardiomyopathy: from pathophysiology to clinical diagnostic tools. Int J Mol Sci. 2023;24(10).","DOI":"10.3390\/ijms24108604"},{"issue":"1","key":"10843_CR86","doi-asserted-by":"publisher","first-page":"H227","DOI":"10.1152\/ajpheart.00340.2004","volume":"288","author":"J Asbun","year":"2005","unstructured":"Asbun J, Manso AM, Villarreal FJ. Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E. Am J Physiol Heart Circ Physiol. 2005;288(1):H227\u201334.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"10843_CR87","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1139\/cjpp-2013-0490","volume":"92","author":"PE Shamhart","year":"2014","unstructured":"Shamhart PE, Luther DJ, Adapala RK, Bryant JE, Petersen KA, Meszaros JG, et al. Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts. Can J Physiol Pharmacol. 2014;92(7):598\u2013604.","journal-title":"Can J Physiol Pharmacol"},{"issue":"9","key":"10843_CR88","doi-asserted-by":"publisher","first-page":"C794","DOI":"10.1152\/ajpcell.00251.2013","volume":"306","author":"H Aguilar","year":"2014","unstructured":"Aguilar H, Fricovsky E, Ihm S, Schimke M, Maya-Ramos L, Aroonsakool N, et al. Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis. Am J Physiol Cell Physiol. 2014;306(9):C794\u2013804.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"12","key":"10843_CR89","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1161\/CIRCRESAHA.124.325918","volume":"136","author":"K Dennis","year":"2025","unstructured":"Dennis K, Gopal K, Montes Aparicio CN, Zhang JA, Castro-Guarda M, Nicol T, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes. Circ Res. 2025;136(12):1545\u201360.","journal-title":"Circ Res"},{"key":"10843_CR90","doi-asserted-by":"publisher","first-page":"109224","DOI":"10.1016\/j.biopha.2019.109224","volume":"118","author":"T Zhao","year":"2019","unstructured":"Zhao T, Chen H, Cheng C, Zhang J, Yan Z, Kuang J, et al. Liraglutide protects high-glucose-stimulated fibroblasts by activating the CD36-JNK-AP1 pathway to downregulate P4HA1. Biomed Pharmacother. 2019;118:109224.","journal-title":"Biomed Pharmacother"},{"key":"10843_CR91","doi-asserted-by":"publisher","first-page":"173376","DOI":"10.1016\/j.ejphar.2020.173376","volume":"888","author":"A Haye","year":"2020","unstructured":"Haye A, Ansari MA, Rahman SO, Shamsi Y, Ahmed D, Sharma M. Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape. Eur J Pharmacol. 2020;888:173376.","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"10843_CR92","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00109-018-1627-8","volume":"96","author":"WJ Liang","year":"2018","unstructured":"Liang WJ, Zhou SN, Shan MR, Wang XQ, Zhang M, Chen Y, et al. AMPK\u03b1 inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2\u03b1\/miRNA-124 axis. J Mol Med (Berl). 2018;96(5):403\u201312.","journal-title":"J Mol Med (Berl)"},{"key":"10843_CR93","doi-asserted-by":"crossref","unstructured":"Xie S, Wang M, Yu C, Zhou F, Zheng Y, Zhang N et al. Aerobic exercise stabilizes HIF1\u03b1 through P4HA1 to activate Nrf2\/GPX4 inhibiting ferroptosis and attenuating diabetic cardiomyopathy. Diabetes Metab J. 2026.","DOI":"10.4093\/dmj.2025.0495"},{"issue":"19","key":"10843_CR94","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","volume":"60","author":"MR Dweck","year":"2012","unstructured":"Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol. 2012;60(19):1854\u201363.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10843_CR95","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11886-016-0753-6","volume":"18","author":"S Badiani","year":"2016","unstructured":"Badiani S, van Zalen J, Treibel TA, Bhattacharyya S, Moon JC, Lloyd G. Aortic Stenosis, a Left Ventricular Disease: Insights from Advanced Imaging. Curr Cardiol Rep. 2016;18(8):80.","journal-title":"Curr Cardiol Rep"},{"issue":"17","key":"10843_CR96","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/eurheartj\/ehi290","volume":"26","author":"M Kupari","year":"2005","unstructured":"Kupari M, Turto H, Lommi J. Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur Heart J. 2005;26(17):1790\u20136.","journal-title":"Eur Heart J"},{"issue":"3","key":"10843_CR97","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/14779072.2023.2186853","volume":"21","author":"N Aziminia","year":"2023","unstructured":"Aziminia N, Nitsche C, Mravljak R, Bennett J, Thornton GD, Treibel TA. Heart failure and excess mortality after aortic valve replacement in aortic stenosis. Expert Rev Cardiovasc Ther. 2023;21(3):193\u2013210.","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"19","key":"10843_CR98","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1136\/heartjnl-2017-311506","volume":"103","author":"PN Kampaktsis","year":"2017","unstructured":"Kampaktsis PN, Kokkinidis DG, Wong SC, Vavuranakis M, Skubas NJ, Devereux RB. The role and clinical implications of diastolic dysfunction in aortic stenosis. Heart. 2017;103(19):1481\u20137.","journal-title":"Heart"},{"issue":"8","key":"10843_CR99","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1093\/eurheartj\/ehx353","volume":"39","author":"TA Treibel","year":"2018","unstructured":"Treibel TA, L\u00f3pez B, Gonz\u00e1lez A, Menacho K, Schofield RS, Ravassa S, et al. Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients. Eur Heart J. 2018;39(8):699\u2013709.","journal-title":"Eur Heart J"},{"issue":"12","key":"10843_CR100","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1016\/j.jcmg.2020.07.007","volume":"13","author":"HJ Lee","year":"2020","unstructured":"Lee HJ, Lee H, Kim SM, Park JB, Kim EK, Chang SA, et al. Diffuse Myocardial Fibrosis and Diastolic Function in Aortic Stenosis. JACC Cardiovasc Imaging. 2020;13(12):2561\u201372.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"10","key":"10843_CR101","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.recesp.2016.12.018","volume":"70","author":"K Echegaray","year":"2017","unstructured":"Echegaray K, Andreu I, Lazkano A, Villanueva I, S\u00e1enz A, Elizalde MR, et al. Role of Myocardial Collagen in Severe Aortic Stenosis With Preserved Ejection Fraction and Symptoms of Heart Failure. Rev Esp Cardiol (Engl Ed). 2017;70(10):832\u201340.","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"8","key":"10843_CR102","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1161\/CIRCULATIONAHA.104.516963","volume":"112","author":"S Heymans","year":"2005","unstructured":"Heymans S, Schroen B, Vermeersch P, Milting H, Gao F, Kassner A, et al. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Circulation. 2005;112(8):1136\u201344.","journal-title":"Circulation"},{"issue":"3","key":"10843_CR103","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1054\/jcaf.2003.26","volume":"9","author":"FJ Ramires","year":"2003","unstructured":"Ramires FJ, Nunes VL, Fernandes F, Mady C, Ramires JA. Endothelins and myocardial fibrosis. J Card Fail. 2003;9(3):232\u20137.","journal-title":"J Card Fail"},{"issue":"12","key":"10843_CR104","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1093\/cvr\/27.12.2130","volume":"27","author":"E Guarda","year":"1993","unstructured":"Guarda E, Katwa LC, Myers PR, Tyagi SC, Weber KT. Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res. 1993;27(12):2130\u20134.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10843_CR105","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ejheart.2006.10.006","volume":"9","author":"J Fielitz","year":"2007","unstructured":"Fielitz J, Philipp S, Herda LR, Schuch E, Pilz B, Schubert C, et al. Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding. Eur J Heart Fail. 2007;9(4):336\u201342.","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10843_CR106","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1161\/01.CIR.103.2.319","volume":"103","author":"F Ammarguellat","year":"2001","unstructured":"Ammarguellat F, Larouche I, Schiffrin EL. Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation. 2001;103(2):319\u201324.","journal-title":"Circulation"},{"issue":"8","key":"10843_CR107","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1073\/pnas.71.8.3019","volume":"71","author":"A Ooshima","year":"1974","unstructured":"Ooshima A, Fuller GC, Cardinale GJ, Spector S, Udenfriend S. Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents. Proc Natl Acad Sci U S A. 1974;71(8):3019\u201323.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10843_CR108","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","volume":"3","author":"S Nattel","year":"2017","unstructured":"Nattel S. Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation. JACC Clin Electrophysiol. 2017;3(5):425\u201335.","journal-title":"JACC Clin Electrophysiol"},{"issue":"6","key":"10843_CR109","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.tcm.2014.12.015","volume":"25","author":"J Jalife","year":"2015","unstructured":"Jalife J, Kaur K. Atrial remodeling, fibrosis, and atrial fibrillation. Trends Cardiovasc Med. 2015;25(6):475\u201384.","journal-title":"Trends Cardiovasc Med"},{"key":"10843_CR110","doi-asserted-by":"publisher","first-page":"798768","DOI":"10.1155\/2015\/798768","volume":"2015","author":"M Miragoli","year":"2015","unstructured":"Miragoli M, Glukhov AV. Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. Biomed Res Int. 2015;2015:798768.","journal-title":"Biomed Res Int"},{"issue":"20","key":"10843_CR111","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/j.jacc.2015.03.557","volume":"65","author":"BJ Hirsh","year":"2015","unstructured":"Hirsh BJ, Copeland-Halperin RS, Halperin JL. Fibrotic atrial cardiomyopathy, atrial fibrillation, and thromboembolism: mechanistic links and clinical inferences. J Am Coll Cardiol. 2015;65(20):2239\u201351.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10843_CR112","first-page":"651","volume":"16","author":"YR Chen","year":"2000","unstructured":"Chen YR, Tan TH. The c-Jun N-terminal kinase pathway and apoptotic signaling (review). Int J Oncol. 2000;16(4):651\u201362.","journal-title":"Int J Oncol"},{"key":"10843_CR113","doi-asserted-by":"publisher","first-page":"116413","DOI":"10.1016\/j.biopha.2024.116413","volume":"173","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Yang Z, Wang S, Wang X, Mao J. Targeting MAPK-ERK\/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure. Biomed Pharmacother. 2024;173:116413.","journal-title":"Biomed Pharmacother"},{"key":"10843_CR114","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jare.2024.09.029","volume":"74","author":"M Hao","year":"2025","unstructured":"Hao M, Lu Y, Yao Z, Wang P, Chen Z, Zhou L, et al. The role of JNK signaling pathway in organ fibrosis. J Adv Res. 2025;74:207\u201323.","journal-title":"J Adv Res"},{"key":"10843_CR115","doi-asserted-by":"crossref","unstructured":"Zhou Y, Xie Y, Li T, Zhang P, Chen T, Fan Z et al. P21\u2013activated kinase 1 mediates angiotensin II\u2013induced differentiation of human atrial fibroblasts via the JNK\/c\u2013Jun pathway. Mol Med Rep. 2021;23(3).","DOI":"10.3892\/mmr.2021.11846"},{"key":"10843_CR116","doi-asserted-by":"publisher","first-page":"609300","DOI":"10.3389\/fcvm.2021.609300","volume":"8","author":"Z Xiao","year":"2021","unstructured":"Xiao Z, Reddy DPK, Xue C, Liu X, Chen X, Li J, et al. Profiling of miR-205\/P4HA3 Following Angiotensin II-Induced Atrial Fibrosis: Implications for Atrial Fibrillation. Front Cardiovasc Med. 2021;8:609300.","journal-title":"Front Cardiovasc Med"},{"issue":"23","key":"10843_CR117","doi-asserted-by":"publisher","first-page":"10403","DOI":"10.1021\/acs.jmedchem.8b00822","volume":"61","author":"JD Vasta","year":"2018","unstructured":"Vasta JD, Raines RT. Collagen Prolyl 4-Hydroxylase as a Therapeutic Target. J Med Chem. 2018;61(23):10403\u201311.","journal-title":"J Med Chem"},{"issue":"4","key":"10843_CR118","doi-asserted-by":"publisher","first-page":"100754","DOI":"10.1016\/j.tranon.2020.100754","volume":"13","author":"S Agarwal","year":"2020","unstructured":"Agarwal S, Behring M, Kim HG, Bajpai P, Chakravarthi B, Gupta N, et al. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020;13(4):100754.","journal-title":"Transl Oncol"},{"issue":"19","key":"10843_CR119","doi-asserted-by":"publisher","first-page":"9397","DOI":"10.1016\/S0021-9258(18)48093-3","volume":"262","author":"T Sasaki","year":"1987","unstructured":"Sasaki T, Majamaa K, Uitto J. Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action. J Biol Chem. 1987;262(19):9397\u2013403.","journal-title":"J Biol Chem"},{"issue":"2\u20133","key":"10843_CR120","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0014-5793(02)03389-6","volume":"529","author":"J Wang","year":"2002","unstructured":"Wang J, Buss JL, Chen G, Ponka P, Pantopoulos K. The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. FEBS Lett. 2002;529(2\u20133):309\u201312.","journal-title":"FEBS Lett"},{"issue":"1","key":"10843_CR121","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1021\/acschembio.5b00749","volume":"11","author":"JD Vasta","year":"2016","unstructured":"Vasta JD, Andersen KA, Deck KM, Nizzi CP, Eisenstein RS, Raines RT. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. ACS Chem Biol. 2016;11(1):193\u20139.","journal-title":"ACS Chem Biol"},{"issue":"1","key":"10843_CR122","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0167-4889(98)00114-1","volume":"1448","author":"H Ju","year":"1998","unstructured":"Ju H, Hao J, Zhao S, Dixon IM. Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts. Biochim Biophys Acta. 1998;1448(1):51\u201360.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10843_CR123","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1172\/JCI117684","volume":"95","author":"TA McCaffrey","year":"1995","unstructured":"McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, Park MH, et al. Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. J Clin Invest. 1995;95(2):446\u201355.","journal-title":"J Clin Invest"},{"issue":"5","key":"10843_CR124","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3892\/ijmm.2020.4531","volume":"45","author":"ZP Wang","year":"2020","unstructured":"Wang ZP, Che Y, Zhou H, Meng YY, Wu HM, Jin YG, et al. Corosolic acid attenuates cardiac fibrosis following myocardial infarction in mice. Int J Mol Med. 2020;45(5):1425\u201335.","journal-title":"Int J Mol Med"},{"issue":"1","key":"10843_CR125","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12906-023-04008-6","volume":"23","author":"FF Tang","year":"2023","unstructured":"Tang FF, Liu L, Tian XT, Li N, Peng YX, Qian CM, et al. Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression. BMC Complement Med Ther. 2023;23(1):171.","journal-title":"BMC Complement Med Ther"},{"issue":"5","key":"10843_CR126","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1159\/000487972","volume":"45","author":"X Li","year":"2018","unstructured":"Li X, Wang G, QiLi M, Liang H, Li T. Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1\/2-Serpine2 and P-Akt Signalling Pathways. Cell Physiol Biochem. 2018;45(5):1955\u201365.","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"10843_CR127","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.taap.2012.01.013","volume":"259","author":"X Wang","year":"2012","unstructured":"Wang X, Lu J, Khaidakov M, Mitra S, Ding Z, Raina S, et al. Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription. Toxicol Appl Pharmacol. 2012;259(3):346\u201354.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"10843_CR128","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s00395-007-0647-2","volume":"102","author":"A Adamek","year":"2007","unstructured":"Adamek A, Hu K, Bayer B, Wagner H, Ertl G, Bauersachs J, et al. High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction. Basic Res Cardiol. 2007;102(4):334\u201340.","journal-title":"Basic Res Cardiol"},{"key":"10843_CR129","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ebiom.2019.06.048","volume":"45","author":"T Wang","year":"2019","unstructured":"Wang T, Fu X, Jin T, Zhang L, Liu B, Wu Y, et al. Aspirin targets P4HA2 through inhibiting NF-\u03baB and LMCD1-AS1\/let-7\u00a0g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma. EBioMedicine. 2019;45:168\u201380.","journal-title":"EBioMedicine"},{"issue":"3","key":"10843_CR130","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/path.4530","volume":"236","author":"Y Luo","year":"2015","unstructured":"Luo Y, Xu W, Chen H, Warburton D, Dong R, Qian B, et al. A novel profibrotic mechanism mediated by TGF\u03b2-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells. J Pathol. 2015;236(3):384\u201394.","journal-title":"J Pathol"},{"issue":"1","key":"10843_CR131","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/HEP.0000000000000317","volume":"78","author":"J Zhang","year":"2023","unstructured":"Zhang J, Lyu Z, Li B, You Z, Cui N, Li Y, et al. P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases. Hepatology. 2023;78(1):10\u201325.","journal-title":"Hepatology"},{"issue":"3","key":"10843_CR132","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.jhep.2012.11.011","volume":"58","author":"J Li","year":"2013","unstructured":"Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, et al. miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J Hepatol. 2013;58(3):522\u20138.","journal-title":"J Hepatol"}],"container-title":["Journal of Cardiovascular Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10843-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12265-026-10843-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12265-026-10843-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:03:04Z","timestamp":1788897784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12265-026-10843-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":132,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10843"],"URL":"https:\/\/doi.org\/10.1007\/s12265-026-10843-y","relation":{},"ISSN":["1937-5387","1937-5395"],"issn-type":[{"value":"1937-5387","type":"print"},{"value":"1937-5395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"11 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This review adheres to all relevant ethical guidelines.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"113"}}