{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:36:04Z","timestamp":1760708164861},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s12272-010-0212-7","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T01:53:13Z","timestamp":1266889993000},"page":"267-273","source":"Crossref","is-referenced-by-count":7,"title":["Enantioselective pharmacokinetics of sibutramine in rat"],"prefix":"10.1007","volume":"33","author":[{"given":"Keumhan","family":"Noh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoungjin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bokyoung","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-il","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taecheon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonku","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,2]]},"reference":[{"key":"212_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jpba.2009.04.024","volume":"50","author":"K. Bae","year":"2009","unstructured":"Bae, K., Noh, K., Jang, K., Kim, S., Yong, C.S., Choi, H. G., Kang, J.S., Chen, J., Ma, E., Lee M., Shin, B. S., Kwon, K. I., and Kang, W., Analysis of enantiomers of sibutramine and its metabolites in rat plasma by liquid chromatography-mass spectrometry using a chiral stationaryphase column. J. Pharm. Biomed. Anal., 50, 267\u2013270 (2009).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"212_CR2","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1124\/dmd.108.020727","volume":"36","author":"S. K. Bae","year":"2008","unstructured":"Bae, S. K., Cao, S., Seo, K. A., Kim, H., Kim, M. J., Shon, J. H., Liu, K. H., Zhou, H. H., and Shin, J. G., Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. Drug Metab. Dispos., 36, 1679\u20131688 (2008).","journal-title":"Drug Metab. Dispos."},{"key":"212_CR3","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1016\/S0957-4166(99)00511-X","volume":"10","author":"Q. K. Fang","year":"1999","unstructured":"Fang, Q. K., Senanayake, C. H., Han, Z., Morency, C., Grover, P., Malone, R. E., Bulter, H., Wald, S. A., and Cameron, T. S., First preparation of enantiomerically pure sibutramine and its major metabolite, and determination of their absolute configuration by single crystal X-ray analysis. Tetrahedron Asymmetry, 10, 4477\u20134480 (1999).","journal-title":"Tetrahedron Asymmetry"},{"key":"212_CR4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(00)00216-8","volume":"397","author":"S. D. Glick","year":"2000","unstructured":"Glick, S. D., Haskew, R. E., Maisonneuve, I. M., Carlson, J. N., and Jerussi, T. P., Enantioselective behavioral effects of sibutramine metabolites. Eur. J. Pharmacol., 397, 93\u2013102 (2000).","journal-title":"Eur. J. Pharmacol."},{"key":"212_CR5","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00216-008-2540-8","volume":"393","author":"K. S. Hakala","year":"2009","unstructured":"Hakala, K. S., Link, M., Szotakova, B., Skalova, L., Kostiainen, R., and Ketola, R. A., Characterization of metabolites of sibutramine in primary cultures of rat hepatocytes by liquid chromatography-ion trap mass spectrometry. Anal. Bioanal. Chem., 393, 1327\u20131336(2009).","journal-title":"Anal. Bioanal. Chem."},{"key":"212_CR6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/jms.1082","volume":"41","author":"M. Link","year":"2006","unstructured":"Link, M., Hakala, K. S., Wsol, V., Kostiainen, R., and Ketola, R. A., Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study. J. Mass Spectrom., 41, 1171\u20131178 (2006).","journal-title":"J. Mass Spectrom."},{"key":"212_CR7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1211\/0022357055678","volume":"57","author":"M. Link","year":"2005","unstructured":"Link, M., Novotn\u00e1, R., Suchanov\u00e1, B., Sk\u00e1lov\u00e1, L., Ws\u00f3l, V., and Szot\u00e1kov\u00e1, B., The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes. J. Pharm. Pharmacol., 57, 405\u2013410 (2005).","journal-title":"J. Pharm. Pharmacol."},{"key":"212_CR8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0028-3908(89)90048-8","volume":"28","author":"G. P. Luscombe","year":"1989","unstructured":"Luscombe, G. P., Hopcroft, R. H., Thomas, P. C., and Buckett, W. R., The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology, 28, 129\u2013134 (1989).","journal-title":"Neuropharmacology"},{"key":"212_CR9","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1345\/aph.18319","volume":"33","author":"C. A. Luque","year":"1999","unstructured":"Luque, C. A. and Rey, J. A., Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann. Pharmacother., 33, 968\u2013977 (1999).","journal-title":"Ann. Pharmacother."}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-010-0212-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-010-0212-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-010-0212-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T12:22:45Z","timestamp":1559564565000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-010-0212-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["212"],"URL":"https:\/\/doi.org\/10.1007\/s12272-010-0212-7","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}