{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:22:57Z","timestamp":1781706177257,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s12272-013-0149-8","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T16:19:20Z","timestamp":1368548360000},"page":"1392-1402","source":"Crossref","is-referenced-by-count":22,"title":["Reversal of multidrug resistance in cancer cells by novel asymmetrical 1,4-dihydropyridines"],"prefix":"10.1007","volume":"36","author":[{"given":"Omidreza","family":"Firuzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoun","family":"Javidnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mansourabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Saso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Mehdipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Miri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"149_CR1","first-page":"495","volume":"26","author":"A Angelini","year":"2012","unstructured":"Angelini, A., R. Di Pietro, L. Centurione, M.L. Castellani, P. Conti, E. Porreca, F. Cuccurullo, and C. Di Ilio. 2012. Inhibition of p-glycoprotein-mediated transport by s-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA\/DX5 cells. Journal of Biological Regulators and Homeostatic Agents 26: 495\u2013504.","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"149_CR2","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.4161\/cc.6.22.4936","volume":"6","author":"P Borst","year":"2007","unstructured":"Borst, P., J. Jonkers, and S. Rottenberg. 2007. What makes tumors multidrug resistant? Cell Cycle 6: 2782.","journal-title":"Cell Cycle"},{"key":"149_CR3","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1158\/1078-0432.CCR-11-1590","volume":"18","author":"KG Chen","year":"2012","unstructured":"Chen, K.G., and B.I. Sikic. 2012. Molecular pathways: Regulation and therapeutic implications of multidrug resistance. Clinical Cancer Research 18: 1863\u20131869.","journal-title":"Clinical Cancer Research"},{"key":"149_CR4","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1021\/jm00162a016","volume":"29","author":"L Dagnino","year":"1986","unstructured":"Dagnino, L., M.C. Li-Kwong-Ken, M.W. Wolowyk, H. Wynn, C.R. Triggle, and E.E. Knaus. 1986. Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates. Journal of Medicinal Chemistry 29: 2524\u20132529.","journal-title":"Journal of Medicinal Chemistry"},{"key":"149_CR5","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.drudis.2009.08.004","volume":"14","author":"N Edraki","year":"2009","unstructured":"Edraki, N., A.R. Mehdipour, M. Khoshneviszadeh, and R. Miri. 2009. Dihydropyridines: Evaluation of their current and future pharmacological applications. Drug Discovery Today 14: 1058\u20131066.","journal-title":"Drug Discovery Today"},{"key":"149_CR6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.phymed.2012.05.010","volume":"19","author":"SY Eid","year":"2012","unstructured":"Eid, S.Y., M.Z. El-Readi, and M. Wink. 2012. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine 19: 977\u2013987.","journal-title":"Phytomedicine"},{"key":"149_CR7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2174\/1389203023380521","volume":"3","author":"KF Ejendal","year":"2002","unstructured":"Ejendal, K.F., and C.A. Hrycyna. 2002. Multidrug resistance and cancer: The role of the human ABC transporter ABCG2. Current Protein and Peptide Science 3: 503\u2013511.","journal-title":"Current Protein and Peptide Science"},{"key":"149_CR8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1211\/jpp.60.11.0009","volume":"60","author":"F Foroughinia","year":"2008","unstructured":"Foroughinia, F., K. Javidnia, Z. Amirghofran, A. Mehdipour, and R. Miri. 2008. Design and synthesis of new symmetrical derivatives of dihydropyridine containing a pyridyl group on the 3,5-positions and evaluation of their cytotoxic and multidrug resistance reversal activity. Journal of Pharmacy and Pharmacology 60: 1481\u20131489.","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"149_CR9","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1021\/jo00200a018","volume":"49","author":"JA Hyatt","year":"1984","unstructured":"Hyatt, J.A., P.L. Feldman, and R.J. Clemens. 1984. Ketenes. 20. Thermal decomposition of 2,2,6-trimethyl-4H-1,3-dioxin-4-one and 1-ethoxybutyn-3-one. Acetylketene. Journal of Organic Chemistry 49: 5105\u20135108.","journal-title":"Journal of Organic Chemistry"},{"key":"149_CR10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s12272-011-0902-9","volume":"34","author":"M Iman","year":"2011","unstructured":"Iman, M., A. Davood, A.R. Nematollahi, A.R. Dehpoor, and A. Shafiee. 2011. Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker. Archives of Pharmacal Research 34: 1417\u20131426.","journal-title":"Archives of Pharmacal Research"},{"key":"149_CR11","volume-title":"Harrison\u2019s principles of internal medicine","author":"DL Kasper","year":"2005","unstructured":"Kasper, D.L., E. Braunwald, A.S. Fauci, S.L. Hauser, D.L. Longo, J.L. Jameson, and K.J. Isselbacher. 2005. Harrison\u2019s principles of internal medicine. New York: McGraw-Hill."},{"key":"149_CR12","volume-title":"Cancer biology","author":"RJB King","year":"2006","unstructured":"King, R.J.B., and M.W. Robins. 2006. Cancer biology. New York: Prentice Hall."},{"key":"149_CR13","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.lfs.2008.09.009","volume":"83","author":"J-S Koo","year":"2008","unstructured":"Koo, J.-S., W.-C. Choi, Y.-H. Rhee, H.-J. Lee, E.-O. Lee, K.S. Ahn, H.-S. Bae, K.-S. Ahn, J.-M. Kang, S.-U. Choi, M.O. Kim, J. Lu, and S.-H. Kim. 2008. Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA\/DX5 cancer cells. Life Sciences 83: 700\u2013708.","journal-title":"Life Sciences"},{"key":"149_CR14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1747-0285.2007.00569.x","volume":"70","author":"AR Mehdipour","year":"2007","unstructured":"Mehdipour, A.R., K. Javidnia, B. Hemmateenejad, Z. Amirghofran, and R. Miri. 2007. Dihydropyridine derivatives to overcome atypical multidrug resistance: Design, synthesis, QSAR studies, and evaluation of their cytotoxic and pharmacological activities. Chemical Biology & Drug Design 70: 337\u2013346.","journal-title":"Chemical Biology & Drug Design"},{"key":"149_CR15","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1016\/j.bmc.2008.07.025","volume":"16","author":"R Miri","year":"2008","unstructured":"Miri, R., and A. Mehdipour. 2008. Dihydropyridines and atypical MDR: A novel perspective of designing general reversal agents for both typical and atypical MDR. Bioorganic & Medicinal Chemistry 16: 8329\u20138334.","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"149_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ardp.201000196","volume":"344","author":"R Miri","year":"2011","unstructured":"Miri, R., R. Motamedi, M.R. Rezaei, O. Firuzi, A. Javidnia, and A. Shafiee. 2011. Design, synthesis and evaluation of cytotoxicity of novel chromeno[4,3-b]quinoline derivatives. Archiv der Pharmazie 344: 111\u2013118.","journal-title":"Archiv der Pharmazie"},{"key":"149_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65: 55\u201363.","journal-title":"Journal of Immunological Methods"},{"key":"149_CR18","first-page":"592","volume":"73","author":"AA Stavrovskaya","year":"2008","unstructured":"Stavrovskaya, A.A., and T.P. Stromskaya. 2008. Transport proteins of the ABC family and multidrug resistance of tumor cells. Biochemistry 73: 592\u2013604.","journal-title":"Biochemistry"},{"key":"149_CR19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","volume":"5","author":"G Szakacs","year":"2006","unstructured":"Szakacs, G., J.K. Paterson, J.A. Ludwig, C. Booth-Genthe, and M.M. Gottesman. 2006. Targeting multidrug resistance in cancer. Nature Reviews Drug Discovery 5: 219\u2013234.","journal-title":"Nature Reviews Drug Discovery"},{"key":"149_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0960-894X(00)00651-X","volume":"11","author":"S Tasaka","year":"2001","unstructured":"Tasaka, S., H. Ohmori, N. Gomi, M. Iino, T. Machida, A. Kiue, S. Naito, and M. Kuwano. 2001. Synthesis and structure\u2013activity analysis of novel dihydropyridine derivatives to overcome multidrug resistance. Bioorganic & Medicinal Chemistry Letters 11: 275\u2013277.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"149_CR21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-827X(02)01229-6","volume":"57","author":"E Teodori","year":"2002","unstructured":"Teodori, E., S. Dei, S. Scapecchi, and F. Gualtieri. 2002. The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Farmaco 57: 385\u2013415.","journal-title":"Farmaco"},{"key":"149_CR22","first-page":"1967","volume":"41","author":"T Tsuruo","year":"1981","unstructured":"Tsuruo, T., H. Iida, S. Tsukagoshi, and Y. Sakurai. 1981. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Research 41: 1967\u20131972.","journal-title":"Cancer Research"},{"key":"149_CR23","first-page":"4730","volume":"42","author":"T Tsuruo","year":"1982","unstructured":"Tsuruo, T., H. Iida, S. Tsukagoshi, and Y. Sakurai. 1982. Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Research 42: 4730\u20134733.","journal-title":"Cancer Research"},{"key":"149_CR24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1747-0285.2010.01025.x","volume":"76","author":"A Zarrin","year":"2010","unstructured":"Zarrin, A., A.R. Mehdipour, and R. Miri. 2010. Dihydropyridines and multidrug resistance: Previous attempts, present state, and future trends. Chemical Biology & Drug Design 76: 369\u2013381.","journal-title":"Chemical Biology & Drug Design"},{"key":"149_CR25","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/jps.20406","volume":"94","author":"X Zhou","year":"2005","unstructured":"Zhou, X., R.A. Coburn, and M.E. Morris. 2005a. Effects of new 4-aryl-1,4-dihydropyridines and 4-arylpyridines on drug efflux mediated by multidrug resistance-associated protein 1. Journal of Pharmaceutical Sciences 94: 2256\u20132265.","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"149_CR26","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1124\/dmd.104.003558","volume":"33","author":"XF Zhou","year":"2005","unstructured":"Zhou, X.F., X. Yang, Q. Wang, R.A. Coburn, and M.E. Morris. 2005b. Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: In vitro and in vivo studies. Drug Metabolism and Disposition 33: 1220\u20131228.","journal-title":"Drug Metabolism and Disposition"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-013-0149-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-013-0149-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-013-0149-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T06:57:30Z","timestamp":1559458650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-013-0149-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["149"],"URL":"https:\/\/doi.org\/10.1007\/s12272-013-0149-8","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}