{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T20:22:51Z","timestamp":1743538971222},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s12272-013-0170-y","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T08:54:38Z","timestamp":1370249678000},"page":"232-238","source":"Crossref","is-referenced-by-count":2,"title":["Attenuated effects of Neu2000 on hypoxia-induced synaptic activities in a rat hippocampus"],"prefix":"10.1007","volume":"37","author":[{"given":"Jihyun","family":"Noh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hyun","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Mo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"170_CR1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.STR.12.6.723","volume":"12","author":"J Astrup","year":"1981","unstructured":"Astrup, J., B.K. Siesjo, and L. Symon. 1981. Thresholds in cerebral ischemia\u2014The ischemic penumbra. Stroke 12: 723\u2013725.","journal-title":"Stroke"},{"key":"170_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.ne.13.030190.001131","volume":"13","author":"DW Choi","year":"1990","unstructured":"Choi, D.W., and S.M. Rothman. 1990. The role of glutamate neurotoxicity in hypoxicischemic neuronal death. Annual Review of Neuroscience 13: 171\u2013182.","journal-title":"Annual Review of Neuroscience"},{"key":"170_CR3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbamcr.2011.10.004","volume":"1823","author":"Y Dong","year":"2012","unstructured":"Dong, Y., W. Zhang, B. Lai, W.J. Luan, Y.H. Zhu, B.Q. Zhao, and P. Zheng. 2012. Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex. Biochimica et Biophysica Acta 1823: 493\u2013504.","journal-title":"Biochimica et Biophysica Acta"},{"key":"170_CR4","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1152\/jn.1998.80.5.2378","volume":"80","author":"G Erdemli","year":"1998","unstructured":"Erdemli, G., Y.Z. Xu, and K. Krnjevi\u0107. 1998. Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia. Journal of Neurophysiology 80: 2378\u20132390.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR5","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1523\/JNEUROSCI.21-13-04600.2001","volume":"21","author":"IA Fleidervish","year":"2001","unstructured":"Fleidervish, I.A., C. Gebhardt, N. Astman, M.J. Gutnick, and U. Heinemann. 2001. Enhanced spontaneous transmitter release is the earliest consequence of neocortical hypoxia that can explain the disruption of normal circuit function. Journal of Neuroscience 21: 4600\u20134608.","journal-title":"Journal of Neuroscience"},{"key":"170_CR6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0006-8993(89)90258-8","volume":"490","author":"JC Fowler","year":"1989","unstructured":"Fowler, J.C. 1989. Adenosine antagonists delay hypoxia-induced depression of neuronal activity in hippocampal brain slice. Brain Research 490: 378\u2013384.","journal-title":"Brain Research"},{"key":"170_CR7","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1073\/pnas.92.10.4715","volume":"92","author":"A Franco-Obreg\u00f3n","year":"1995","unstructured":"Franco-Obreg\u00f3n, A., J. Ure\u00f1a, and J. L\u00f3pez-Barneo. 1995. Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. Proceedings of the National Academy of Sciences of the United States of America 92: 4715\u20134719.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"170_CR8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1152\/jn.1997.77.1.378","volume":"77","author":"N Fujimura","year":"1997","unstructured":"Fujimura, N., E. Tanaka, S. Yamamoto, M. Shigemori, and H. Higashi. 1997. Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. Journal of Neurophysiology 77: 378\u2013385.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR9","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1073\/pnas.060574597","volume":"97","author":"D Furling","year":"2000","unstructured":"Furling, D., O. Ghribi, A. Lahsaini, M.E. Mirault, and G. Massicotte. 2000. Impairment of synaptic transmission by transient hypoxia in hippocampal slices: improved recovery in glutathione peroxidase transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 97: 4351\u20134356.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"170_CR10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/sj.jcbfm.9600418","volume":"27","author":"BJ Gwag","year":"2007","unstructured":"Gwag, B.J., Y.A. Lee, S.Y. Ko, M.J. Lee, D.S. Im, B.S. Yun, H.R. Lim, S.M. Park, H.Y. Byun, S.J. Son, H.J. Kwon, J.Y. Lee, J.Y. Cho, S.J. Won, K.W. Kim, Y.M. Ahn, H.S. Moon, H.U. Lee, S.H. Yoon, J.H. Noh, J.M. Chung, and S.I. Cho. 2007. Marked prevention of ischemic brain injury by Neu 2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. Journal of Cerebral Blood Flow and Metabolism 27: 1142\u20131151.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"170_CR11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrn2911","volume":"11","author":"GE Hardingham","year":"2010","unstructured":"Hardingham, G.E., and H. Bading. 2010. Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders. Nature Reviews Neuroscience 11: 682\u2013696.","journal-title":"Nature Reviews Neuroscience"},{"key":"170_CR12","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1152\/jn.1993.69.2.432","volume":"69","author":"N Hershkowitz","year":"1993","unstructured":"Hershkowitz, N., A.N. Katchman, and S. Veregge. 1993. Site of synaptic depression during hypoxia: a patch-clamp analysis. Journal of Neurophysiology 69: 432\u2013441.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/364535a0","volume":"364","author":"M Lafon-Cazal","year":"1993","unstructured":"Lafon-Cazal, M., S. Pietri, M. Culcasi, and J. Bockaert. 1993. NMDA-dependent superoxide production and neurotoxicity. Nature 364: 535\u2013537.","journal-title":"Nature"},{"key":"170_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1989.62.1.1","volume":"62","author":"J Leblond","year":"1989","unstructured":"Leblond, J., and K. Krnjevi\u0107. 1989. Hypoxic changes in hippocampal neurons. Journal of Neurophysiology 62: 1\u201314.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","volume":"79","author":"P Lipton","year":"1999","unstructured":"Lipton, P. 1999. Ischemic cell death in brain neurons. Physiological Reviews 79: 1431\u20131568.","journal-title":"Physiological Reviews"},{"key":"170_CR16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1113\/jphysiol.1979.sp012668","volume":"287","author":"P Lipton","year":"1979","unstructured":"Lipton, P., and T.S. Whittingham. 1979. The effect of hypoxia on evoked potentials in the in vitro hippocampus. Journal of Physiology 287: 427\u2013438.","journal-title":"Journal of Physiology"},{"key":"170_CR17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1172\/JCI7291","volume":"104","author":"H Liu","year":"1999","unstructured":"Liu, H., E. Moczydlowski, and G.G. Haddad. 1999. O2 deprivation inhibits Ca2+-activated K+ channels via cytosolic factors in mice neocortical neurons. Journal of Clinical Investigation 104: 577\u2013588.","journal-title":"Journal of Clinical Investigation"},{"key":"170_CR18","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1152\/jn.1992.67.4.798","volume":"67","author":"HJ Luhmann","year":"1992","unstructured":"Luhmann, H.J., and U. Heinemann. 1992. Hypoxia-induced functional alterations in adult rat neocortex. Journal of Neurophysiology 67: 798\u2013811.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-8993(75)90515-6","volume":"98","author":"A Mayevsky","year":"1975","unstructured":"Mayevsky, A., and B. Chance. 1975. Metabolic responses of the awake cerebral cortex to anoxia hypoxia spreading depression and epileptiform activity. Brain Research 98: 149\u2013165.","journal-title":"Brain Research"},{"key":"170_CR20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0165-6147(90)90129-V","volume":"11","author":"D Nicholls","year":"1990","unstructured":"Nicholls, D., and D. Attwell. 1990. The release and uptake of excitatory aminoacids. Trends in Pharmacological Sciences 11: 462\u2013468.","journal-title":"Trends in Pharmacological Sciences"},{"key":"170_CR21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1471-4159.2009.06044.x","volume":"109","author":"J Noh","year":"2009","unstructured":"Noh, J., E.S. Lee, and J.M. Chung. 2009. The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons. Journal of Neurochemistry 109: 1261\u20131271.","journal-title":"Journal of Neurochemistry"},{"key":"170_CR22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1469-7793.1997.479bg.x","volume":"503","author":"JP O\u2019Reilly","year":"1997","unstructured":"O\u2019Reilly, J.P., T.R. Cummins, and G.G. Haddad. 1997. Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C. Journal of Physiology 503: 479\u2013488.","journal-title":"Journal of Physiology"},{"key":"170_CR23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-010-0785-8","volume":"121","author":"UJ Park","year":"2011","unstructured":"Park, U.J., Y.A. Lee, S.M. Won, J.H. Lee, S.H. Kang, J.E. Springer, Y.B. Lee, and B.J. Gwag. 2011. Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat. Acta Neuropathologica 121: 459\u2013473.","journal-title":"Acta Neuropathologica"},{"key":"170_CR24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.410190202","volume":"19","author":"SM Rothman","year":"1986","unstructured":"Rothman, S.M., and J.W. Olney. 1986. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Annals of Neurology 19: 105\u2013111.","journal-title":"Annals of Neurology"},{"key":"170_CR25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1124\/mol.106.030676","volume":"71","author":"JH Shin","year":"2007","unstructured":"Shin, J.H., S.I. Cho, H.R. Lim, J.K. Lee, Y.A. Lee, J.S. Noh, I.S. Joo, K.W. Kim, and B.J. Gwag. 2007. Concurrent administration of Neu 2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. Molecular Pharmacology 71: 965\u2013975.","journal-title":"Molecular Pharmacology"},{"key":"170_CR26","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.6093256","volume":"226","author":"RP Simon","year":"1984","unstructured":"Simon, R.P., J.H. Swan, T. Griffiths, and B.S. Meldrum. 1984. Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain. Science 226: 850\u2013852.","journal-title":"Science"},{"key":"170_CR27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/neu.2009.0952","volume":"27","author":"JE Springer","year":"2010","unstructured":"Springer, J.E., R.R. Rao, H.R. Lim, S.I. Cho, G.J. Moon, H.Y. Lee, E.J. Park, J.S. Noh, and B.J. Gwag. 2010. The functional and neuroprotective actions of Neu 2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury. Journal of Neurotrauma 27: 139\u2013149.","journal-title":"Journal of Neurotrauma"},{"key":"170_CR28","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1152\/jn.00771.2005","volume":"95","author":"CG Thomas","year":"2006","unstructured":"Thomas, C.G., A.J. Miller, and G.L. Westbrook. 2006. Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. Journal of Neurophysiology 95: 1727\u20131734.","journal-title":"Journal of Neurophysiology"},{"key":"170_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(00)00386-5","volume":"179","author":"BC White","year":"2000","unstructured":"White, B.C., J.M. Sullivan, D.J. DeGracia, B.J. O\u2019Neil, R.W. Neumar, L.I. Grossman, J.A. Rafols, and G.S. Krause. 2000. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. Journal of the Neurological Sciences 179: 1\u201333.","journal-title":"Journal of the Neurological Sciences"},{"key":"170_CR30","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1523\/JNEUROSCI.6371-11.2012","volume":"32","author":"CM Wroge","year":"2012","unstructured":"Wroge, C.M., J. Hogins, L. Eisenman, and S. Mennerick. 2012. Synaptic NMDA receptors mediate hypoxic excitotoxic death. Journal of Neuroscience 32: 6732\u20136742.","journal-title":"Journal of Neuroscience"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-013-0170-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-013-0170-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-013-0170-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T12:03:51Z","timestamp":1563105831000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-013-0170-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["170"],"URL":"https:\/\/doi.org\/10.1007\/s12272-013-0170-y","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,4]]}}}