{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:59:04Z","timestamp":1786982344548,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s12272-014-0365-x","type":"journal-article","created":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T04:14:28Z","timestamp":1395548068000},"page":"1286-1294","source":"Crossref","is-referenced-by-count":16,"title":["Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis"],"prefix":"10.1007","volume":"37","author":[{"given":"Sang Yeob","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyeong","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Tae","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hyun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"issue":"8","key":"365_CR1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","volume":"29","author":"R Altman","year":"1986","unstructured":"Altman, R., E. Asch, D. Bloch, G. Bole, D. Borenstein, K. Brandt, W. Christy, T.D. Cooke, R. Greenwald, and M. Hochberg. 1986. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and therapeutic criteria committee of the American rheumatism association. Arthritis and Rheumatism 29(8): 1039\u20131049.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/s10165-008-0054-z","volume":"18","author":"SP Ardoin","year":"2008","unstructured":"Ardoin, S.P., and D.S. Pisetsky. 2008. The role of cell death in the pathogenesis of autoimmune disease: HMGB1 and microparticles as intercellular mediators of inflammation. Modern Rheumatology 18: 319\u2013326.","journal-title":"Modern Rheumatology"},{"key":"365_CR3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, and H.S. Luthra. 1988. The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism 31: 315\u2013324.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","volume":"233","author":"B Bartok","year":"2010","unstructured":"Bartok, B., and G.S. Firestein. 2010. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunological Reviews 233: 233\u2013255.","journal-title":"Immunological Reviews"},{"key":"365_CR5","doi-asserted-by":"crossref","first-page":"29571","DOI":"10.1074\/jbc.M302924200","volume":"278","author":"CA Belmokhtar","year":"2003","unstructured":"Belmokhtar, C.A., J. Hillion, C. Dudognon, S. Fiorentino, M. Flexor, M. Lanotte, and E. S\u00e9gal-bendirdjian. 2003. Aopotosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes. Journal of Biological Chemistry 278: 29571\u201329580.","journal-title":"Journal of Biological Chemistry"},{"key":"365_CR6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.60.8.729","volume":"60","author":"M Cutolo","year":"2001","unstructured":"Cutolo, M., A. Sulli, C. Pizzorni, B. Seriolo, and R.H. Straub. 2001. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Annals of the Rheumatic Diseases 60: 729\u2013735.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"365_CR7","doi-asserted-by":"crossref","first-page":"R844","DOI":"10.1186\/ar1752","volume":"7","author":"TR Sylva Da","year":"2005","unstructured":"Da Sylva, T.R., A. Connor, Y. Mburu, E. Keystone, and G.E. Wu. 2005. Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Arthritis Research and Therapy 7: R844\u2013R851.","journal-title":"Arthritis Research and Therapy"},{"key":"365_CR8","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1081\/NCN-200027365","volume":"23","author":"S Lathouder de","year":"2004","unstructured":"de Lathouder, S., A.H. Gerards, B.A. Dijkmans, and L.A. Aarden. 2004. Two inhibitors of DNA syntheses lead to inhibition of cytokine production via a different mechanism. Nucleosides, Nucleotides and Nucleic 23: 1089\u20131100.","journal-title":"Nucleosides, Nucleotides and Nucleic"},{"key":"365_CR9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein, G.S. 2003. Evolving concepts of rheumatoid arthritis. Nature 423: 356\u2013361.","journal-title":"Nature"},{"key":"365_CR10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/art.1780310301","volume":"31","author":"DE Furst","year":"1988","unstructured":"Furst, D.E., and J.M. Kremer. 1988. Methotrexate in rheumatoid arthritis. Arthritis and Rheumatism 31: 305\u2013314.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR11","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/rheumatology\/keg323","volume":"42","author":"AH Gerards","year":"2003","unstructured":"Gerards, A.H., S. de Lathouder, E.R. de Groot, B.A. Dijkmans, and L.A. Aarden. 2003. Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis. Rheumatology 42: 1189\u20131196.","journal-title":"Rheumatology"},{"key":"365_CR12","first-page":"111","volume":"23","author":"LJ Gibbons","year":"2009","unstructured":"Gibbons, L.J., and K.L. Hyrich. 2009. Biologic therapy for rheumatoid arthritis: clinical efficacy and predictors of response. Bio Drugs 23: 111\u2013124.","journal-title":"Bio Drugs"},{"key":"365_CR13","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.4049\/jimmunol.170.7.3603","volume":"170","author":"Y Gu","year":"2003","unstructured":"Gu, Y., C. Wang, C.M. Roifman, and A. Cohen. 2003. Role of MHC class I in immune surveillance of mitochondrial DNA integrity. Journal of Immunology 170: 3603\u20133607.","journal-title":"Journal of Immunology"},{"key":"365_CR14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1247\/csf.28.113","volume":"28","author":"S Herman","year":"2003","unstructured":"Herman, S., N. Zurgil, P. Langevitz, M. Ehrenfeld, and M. Deutsch. 2003. The induction of apoptosis by methotrexate in activated lymphocytes as indicated by fluorescence hyperpolarization: A possible model for predicting methotrexate therapy for rheumatoid arthritis patients. Cell Structure and Function 28: 113\u2013122.","journal-title":"Cell Structure and Function"},{"key":"365_CR15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00011-005-1355-8","volume":"54","author":"S Herman","year":"2005","unstructured":"Herman, S., N. Zurgil, and M. Deutsch. 2005. Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines. Inflammation Research 54: 273\u2013280.","journal-title":"Inflammation Research"},{"key":"365_CR16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10495-006-4002-0","volume":"11","author":"PC Hsu","year":"2006","unstructured":"Hsu, P.C., T.C. Hour, Y.F. Liao, Y.C. Hung, C.C. Liu, W.H. Chang, M.C. Kao, G.J. Tsay, H.C. Hung, and G.Y. Liu. 2006. Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. Apoptosis 11: 389\u2013399.","journal-title":"Apoptosis"},{"key":"365_CR17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s10495-005-2947-z","volume":"10","author":"CC Huang","year":"2005","unstructured":"Huang, C.C., P.C. Hsu, Y.C. Hung, C.C. Liad, C.T. Liu, C.M. Hour, G.J. Kao, G.J. Tsay, G.Y. Hung, and G.Y. Liu. 2005. Ornithine decarboxylase prevents methotrexateinduced apoptosis by reducing intracellular reactive oxygen species production. Apoptosis 10: 895\u2013907.","journal-title":"Apoptosis"},{"key":"365_CR18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1139\/O07-014","volume":"85","author":"XB Jing","year":"2007","unstructured":"Jing, X.B., X.B. Cai, H. Hu, S.Z. Chen, B.M. Chen, and J.Y. Cai. 2007. Reactive oxygen species and mitochondrial membrane potential are modulated during CDDP-induced apoptosis in EC-109 cells. Biochemistry and Cell Biology 85: 265\u2013271.","journal-title":"Biochemistry and Cell Biology"},{"key":"365_CR19","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/cncr.20947","volume":"103","author":"R Kim","year":"2005","unstructured":"Kim, R. 2005. Recent advances in understanding the cell death pathways activated by anticancer therapy. Cancer 103: 1551\u20131560.","journal-title":"Cancer"},{"key":"365_CR20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00280-005-0111-7","volume":"57","author":"R Kim","year":"2006","unstructured":"Kim, R., M. Emi, and K. Tanabe. 2006. Role of mitochondria as the gardens of cell death. Cancer Chemotherapy and Pharmacology 57: 545\u2013553.","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"365_CR21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10495-009-0317-y","volume":"14","author":"A Korb","year":"2009","unstructured":"Korb, A., H. Pavenst\u00e4dt, and T. Pap. 2009. Cell death in rheumatoid arthritis. Apoptosis 14: 447\u2013454.","journal-title":"Apoptosis"},{"key":"365_CR22","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1136\/ard.2003.014738","volume":"639","author":"MC Kraan","year":"2004","unstructured":"Kraan, M.C., T.J. Smeets, M.J. van Loon, F.C. Breedveld, B.A. Dijkmans, and P.P. Tak. 2004. Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. Annals of the Rheumatic Diseases 639: 1056\u20131061.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"365_CR23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1172\/JCI114011","volume":"83","author":"R Lafyatis","year":"1989","unstructured":"Lafyatis, R., E.F. Remmers, A.B. Roberts, D.E. Yocum, M.B. Sporn, and R.L. Wilder. 1989. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. Journal of Clinical Investigation. 83(4): 1267\u20131276.","journal-title":"Journal of Clinical Investigation."},{"key":"365_CR24","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm.2050","volume":"15","author":"S Lefevre","year":"2009","unstructured":"Lefevre, S., A. Knedla, C. Tennie, A. Kampmann, C. Wunrau, R. Dinser, A. Korb, E.M. Schn\u00e4ker, I.H. Tarner, P.D. Robbins, C.H. Evans, H. St\u00fcrz, J. Steinmeyer, S. Gay, J. Sch\u00f6lmerich, T. Pap, U. M\u00fcller-Ldner, and E. Neumann. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nature Medicine 15: 1414\u20131420.","journal-title":"Nature Medicine"},{"key":"365_CR25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00296-002-0188-9","volume":"22","author":"B M\u00f6ller","year":"2002","unstructured":"M\u00f6ller, B., N. Kukoc-Zivojnov, S. Okamgba, U. Kessler, E. Puccetti, O.G. Ottmann, J.P. Kaltwasser, D. Hoelzer, and M. Ruthardt. 2002. Folinic acid antagonizes methotrexateinduced differentiation of monocyte progenitors. Rheumatology International 22: 60\u201367.","journal-title":"Rheumatology International"},{"key":"365_CR26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar2337","volume":"9","author":"U Muller-Ladner","year":"2007","unstructured":"Muller-Ladner, U., C. Ospelt, S. Gay, O. Distler, and T. Pap. 2007. Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts. Arthritis Research and Therapy 9: 223.","journal-title":"Arthritis Research and Therapy"},{"issue":"5","key":"365_CR27","first-page":"1607","volume":"149","author":"U M\u00fcller-Ladner","year":"1996","unstructured":"M\u00fcller-Ladner, U., J. Kriegsmann, B.N. Franklin, S. Matsumoto, T. Geiler, R.E. Gay, and S. Gay. 1996. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. American Journal of Pathology 149(5): 1607\u20131615.","journal-title":"American Journal of Pathology"},{"key":"365_CR28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/ard.55.4.237","volume":"55","author":"A Nakajima","year":"1996","unstructured":"Nakajima, A., M. Hakoda, H. Yamanaka, N. Kamatani, and S. Kashiwazaki. 1996. Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 55: 237\u2013242.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"8","key":"365_CR29","first-page":"1800","volume":"28","author":"F Nakazawa","year":"2001","unstructured":"Nakazawa, F., H. Matsuno, K. Yudoh, R. Katayama, T. Sawai, M. Uzuki, and T. Kimura. 2001. Methotrexate inhibits rheumatoid synovitis by inducing apoptosis. Journal of Rheumatology 28(8): 1800\u20131808.","journal-title":"Journal of Rheumatology"},{"key":"365_CR30","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/art.11166","volume":"48","author":"M Neidhart","year":"2003","unstructured":"Neidhart, M., C.A. Seemayer, K.M. Hummel, B.A. Michel, R.E. Gay, and S. Gay. 2003. Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: Destructive potential in vitro and in vivo. Arthritis and Rheumatism 48: 1873\u20131880.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-065X.2008.00648.x","volume":"223","author":"EH Noss","year":"2008","unstructured":"Noss, E.H., and M.B. Brenner. 2008. The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunological Reviews 223: 252\u2013270.","journal-title":"Immunological Reviews"},{"issue":"Suppl 4","key":"365_CR32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/ard.2005.042424","volume":"64","author":"T Pap","year":"2005","unstructured":"Pap, T., I. Meinecke, U. M\u00fcller-Ladner, and S. Gay. 2005. Are fibroblasts involved in joint destruction? Annals of the Rheumatic Diseases 64(Suppl 4): 52\u201354.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"365_CR33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/art.27297","volume":"62","author":"H Perlman","year":"2010","unstructured":"Perlman, H., and R.M. Pope. 2010. The synovial lining micromass system: Toward rheumatoid arthritis in a dish? Arthritis and Rheumatism 62: 643\u2013646.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.bjp.0705054","volume":"138","author":"DC Phillips","year":"2003","unstructured":"Phillips, D.C., K.J. Woollard, and H.R. Griffiths. 2003. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. British Journal of Pharmacology 138: 501\u2013511.","journal-title":"British Journal of Pharmacology"},{"key":"365_CR35","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.4049\/jimmunol.170.10.4986","volume":"170","author":"L Quemeneur","year":"2003","unstructured":"Quemeneur, L., L.M. Gerland, M. Flacher, M. Ffrench, J.P. Revillard, and L. Genestier. 2003. Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides. Journal of Immunology 170: 4986\u20134995.","journal-title":"Journal of Immunology"},{"key":"365_CR36","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/art.20186","volume":"50","author":"E Rutkauskaite","year":"2004","unstructured":"Rutkauskaite, E., W. Zacharias, J. Schedel, U. M\u00fcer-Ladner, C. Mawrin, C.A. Seemayer, D. Alexander, R.E. Gay, W.K. Aicher, B.A. Michel, S. Gay, and T. Pap. 2004. Ribozymes that inhibit the production of matrix metalloproteinase one reduced the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis and Rheumatism 50: 1448\u20131456.","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"365_CR37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S Linden Van der","year":"1984","unstructured":"Van der Linden, S., H.A. Valkenburg, and A. Cats. 1984. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis and Rheumatism 27(4): 361\u2013368.","journal-title":"Arthritis and Rheumatism"},{"key":"365_CR38","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/1529-0131(199810)41:10<1845::AID-ART17>3.0.CO;2-K","volume":"41","author":"AM Gestel Van","year":"1998","unstructured":"Van Gestel, A.M., C.J. Haagsma, and P.L. van Riel. 1998. Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis and Rheumatism 41: 1845\u20131850.","journal-title":"Arthritis and Rheumatism"},{"issue":"3","key":"365_CR39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/rheumatology\/kem279","volume":"47","author":"JA Wessels","year":"2008","unstructured":"Wessels, J.A., T.W. Huizinga, and H.J. Guchelaar. 2008. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford) 47(3): 249\u2013255.","journal-title":"Rheumatology (Oxford)"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-014-0365-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-014-0365-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-014-0365-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:05:27Z","timestamp":1746144327000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-014-0365-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["365"],"URL":"https:\/\/doi.org\/10.1007\/s12272-014-0365-x","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]}}}