{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:32:54Z","timestamp":1777505574462,"version":"3.51.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T00:00:00Z","timestamp":1500681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1 A2 A1 A10052511"],"award-info":[{"award-number":["NRF-2015R1 A2 A1 A10052511"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s12272-017-0931-0","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T09:13:42Z","timestamp":1500714822000},"page":"921-932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of decreased BCAA synthesis through disruption of ilvC gene on the virulence of Streptococcus pneumoniae"],"prefix":"10.1007","volume":"40","author":[{"given":"Gyu-Lee","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungyeop","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truc Thanh","family":"Luong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuong Thach","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Sang","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhkneung","family":"Pyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Kwon","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,22]]},"reference":[{"key":"931_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0882-4010(95)90125-6","volume":"18","author":"IS Aaberge","year":"1995","unstructured":"Aaberge IS, Eng J, Lermark G, Lovik M (1995) Virulence of Streptococcus pneumoniae in mice: a standardized method for preparation and frozen storage of the experimental bacterial inoculum. Microb Pathog 18:141\u2013152","journal-title":"Microb Pathog"},{"key":"931_CR2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/mpat.1997.0185","volume":"24","author":"JE Alexander","year":"1998","unstructured":"Alexander JE, Berry AM, Paton JC, Rubins JB, Andrew PW, Mitchell TJ (1998) Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microb Pathog 24:167\u2013174","journal-title":"Microb Pathog"},{"key":"931_CR3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1128\/AEM.48.6.1111-1117.1984","volume":"48","author":"MJ Allison","year":"1984","unstructured":"Allison MJ, Baetz AL, Wiegel J (1984) Alternative pathways for biosynthesis of leucine and other amino acids in Bacteroides ruminicola and Bacteroides fragilis. Appl Environ Microbiol 48:1111\u20131117","journal-title":"Appl Environ Microbiol"},{"key":"931_CR4","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1128\/IAI.70.9.5290-5294.2002","volume":"70","author":"T Atkins","year":"2002","unstructured":"Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PC, Dougan G, Titball RW (2002) A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun 70:5290\u20135294","journal-title":"Infect Immun"},{"key":"931_CR5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF03401572","volume":"1","author":"OT Avery","year":"1995","unstructured":"Avery OT, Macleod CM, Mccarty M (1995) Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III. 1944. Mol Med 1:344\u2013365","journal-title":"Mol Med"},{"key":"931_CR6","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1099\/mic.0.029884-0","volume":"155","author":"D Awasthy","year":"2009","unstructured":"Awasthy D, Gaonkar S, Shandil RK, Yadav R, Bharath S, Marcel N, Subbulakshmi V, Sharma U (2009) Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice. Microbiology 155:2978\u20132987","journal-title":"Microbiology"},{"key":"931_CR7","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1128\/IAI.01543-08","volume":"77","author":"S Basavanna","year":"2009","unstructured":"Basavanna S, Khandavilli S, Yuste J, Cohen JM, Hosie AH, Webb AJ, Thomas GH, Brown JS (2009) Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis. Infect Immun 77:3412\u20133423","journal-title":"Infect Immun"},{"key":"931_CR8","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/IAI.57.8.2324-2330.1989","volume":"57","author":"AM Berry","year":"1989","unstructured":"Berry AM, Lock RA, Hansman D, Paton JC (1989) Contribution of autolysin to virulence of Streptococcus pneumoniae. Infect Immun 57:2324\u20132330","journal-title":"Infect Immun"},{"key":"931_CR9","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1286-4579(01)01496-4","volume":"3","author":"CR Beuzon","year":"2001","unstructured":"Beuzon CR, Holden DW (2001) Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo. Microbes Infect 3:1345\u20131352","journal-title":"Microbes Infect"},{"key":"931_CR10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","volume":"4","author":"D Bogaert","year":"2004","unstructured":"Bogaert D, De Groot R, Hermans PW (2004) Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 4:144\u2013154","journal-title":"Lancet Infect Dis"},{"key":"931_CR11","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1128\/IAI.70.12.6871-6879.2002","volume":"70","author":"JD Boyce","year":"2002","unstructured":"Boyce JD, Wilkie I, Harper M, Paustian ML, Kapur V, Adler B (2002) Genomic scale analysis of Pasteurella multocida gene expression during growth within the natural chicken host. Infect Immun 70:6871\u20136879","journal-title":"Infect Immun"},{"key":"931_CR12","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1128\/JB.00937-10","volume":"192","author":"SR Brinsmade","year":"2010","unstructured":"Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL (2010) Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools. J Bacteriol 192:6357\u20136368","journal-title":"J Bacteriol"},{"key":"931_CR13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.mi.39.100185.002523","volume":"39","author":"MR Brown","year":"1985","unstructured":"Brown MR, Williams P (1985) The influence of environment on envelope properties affecting survival of bacteria in infections. Annu Rev Microbiol 39:527\u2013556","journal-title":"Annu Rev Microbiol"},{"key":"931_CR14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12866-016-0881-6","volume":"16","author":"JC Bryant","year":"2016","unstructured":"Bryant JC, Dabbs RC, Oswalt KL, Brown LR, Rosch JW, Seo KS, Donaldson JR, Mcdaniel LS, Thornton JA (2016) Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release. BMC Microbiol 16:271","journal-title":"BMC Microbiol"},{"key":"931_CR15","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/archinte.1991.00400080096018","volume":"151","author":"JJ Bullen","year":"1991","unstructured":"Bullen JJ, Spalding PB, Ward CG, Gutteridge JM (1991) Hemochromatosis, iron and septicemia caused by Vibrio vulnificus. Arch Intern Med 151:1606\u20131609","journal-title":"Arch Intern Med"},{"key":"931_CR16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/infdis\/172.1.119","volume":"172","author":"JR Canvin","year":"1995","unstructured":"Canvin JR, Marvin AP, Sivakumaran M, Paton JC, Boulnois GJ, Andrew PW, Mitchell TJ (1995) The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. J Infect Dis 172:119\u2013123","journal-title":"J Infect Dis"},{"key":"931_CR17","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1128\/AEM.66.12.5128-5133.2000","volume":"66","author":"P Garault","year":"2000","unstructured":"Garault P, Letort C, Juillard V, Monnet V (2000) Branched-chain amino acid biosynthesis is essential for optimal growth of Streptococcus thermophilus in milk. Appl Environ Microbiol 66:5128\u20135133","journal-title":"Appl Environ Microbiol"},{"key":"931_CR18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/cmi.12227","volume":"16","author":"G Gesbert","year":"2014","unstructured":"Gesbert G, Ramond E, Rigard M, Frapy E, Dupuis M, Dubail I, Barel M, Henry T, Meibom K, Charbit A (2014) Asparagine assimilation is critical for intracellular replication and dissemination of Francisella. Cell Microbiol 16:434\u2013449","journal-title":"Cell Microbiol"},{"key":"931_CR19","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-49376-3","volume-title":"Listeria monocytogenes: pathogenesis and host response","author":"H Goldfine","year":"2007","unstructured":"Goldfine H, Shen H (2007) Listeria monocytogenes: pathogenesis and host response. Springer Science & Business Media, Berlin"},{"key":"931_CR20","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1128\/jb.174.10.3212-3219.1992","volume":"174","author":"JA Grandoni","year":"1992","unstructured":"Grandoni JA, Zahler SA, Calvo JM (1992) Transcriptional regulation of the ilv-leu operon of Bacillus subtilis. J Bacteriol 174:3212\u20133219","journal-title":"J Bacteriol"},{"key":"931_CR21","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1074\/jbc.M111.304311","volume":"287","author":"T Hartel","year":"2012","unstructured":"Hartel T, Eylert E, Schulz C, Petruschka L, Gierok P, Grubmuller S, Lalk M, Eisenreich W, Hammerschmidt S (2012) Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem 287:4260\u20134274","journal-title":"J Biol Chem"},{"key":"931_CR22","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1128\/IAI.01004-07","volume":"76","author":"WT Hendriksen","year":"2008","unstructured":"Hendriksen WT, Kloosterman TG, Bootsma HJ, Estevao S, De Groot R, Kuipers OP, Hermans PW (2008) Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae. Infect Immun 76:1230\u20131238","journal-title":"Infect Immun"},{"key":"931_CR23","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1086\/527322","volume":"197","author":"RA Hirst","year":"2008","unstructured":"Hirst RA, Gosai B, Rutman A, Guerin CJ, Nicotera P, Andrew PW, O\u2019callaghan C (2008) Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis. J Infect Dis 197:744\u2013751","journal-title":"J Infect Dis"},{"key":"931_CR24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","volume":"10","author":"MI Hood","year":"2012","unstructured":"Hood MI, Skaar EP (2012) Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol 10:525\u2013537","journal-title":"Nat Rev Microbiol"},{"key":"931_CR25","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1128\/IAI.71.4.1813-1819.2003","volume":"71","author":"R Jounblat","year":"2003","unstructured":"Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW (2003) Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. Infect Immun 71:1813\u20131819","journal-title":"Infect Immun"},{"key":"931_CR26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1128\/IAI.68.2.492-501.2000","volume":"68","author":"A Kadioglu","year":"2000","unstructured":"Kadioglu A, Gingles NA, Grattan K, Kerr A, Mitchell TJ, Andrew PW (2000) Host cellular immune response to pneumococcal lung infection in mice. Infect Immun 68:492\u2013501","journal-title":"Infect Immun"},{"key":"931_CR27","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.vaccine.2011.11.073","volume":"30","author":"EH Kim","year":"2012","unstructured":"Kim EH, Choi SY, Kwon MK, Tran TD, Park SS, Lee KJ, Bae SM, Briles DE, Rhee DK (2012) Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice. Vaccine 30:2008\u20132019","journal-title":"Vaccine"},{"key":"931_CR28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1146\/annurev-immunol-020711-074948","volume":"30","author":"P Kuballa","year":"2012","unstructured":"Kuballa P, Nolte WM, Castoreno AB, Xavier RJ (2012) Autophagy and the immune system. Annu Rev Immunol 30:611\u2013646","journal-title":"Annu Rev Immunol"},{"key":"931_CR29","doi-asserted-by":"crossref","first-page":"e46836","DOI":"10.1371\/journal.pone.0046836","volume":"7","author":"T Lei","year":"2012","unstructured":"Lei T, Yang J, Zheng L, Markowski T, Witthuhn BA, Ji Y (2012) The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis. PLoS ONE 7:e46836","journal-title":"PLoS ONE"},{"key":"931_CR30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0264-410X(00)00236-X","volume":"19","author":"M Lipsitchab","year":"2000","unstructured":"Lipsitchab M, Dykesa JK, Johnsona SE, Adesa EW, Kingc J, Brilesc DE, Carlonea GM (2000) Competition among Streptococcus pneumoniae for intranasal colonization in amouse model. Vaccine 19:598","journal-title":"Vaccine"},{"key":"931_CR31","doi-asserted-by":"crossref","unstructured":"Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, Cousens S, Mathers C, Black RE (2015) Global, regional, and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 385(9966):430\u2013440","DOI":"10.1016\/S0140-6736(14)61698-6"},{"key":"931_CR32","doi-asserted-by":"crossref","first-page":"e1002887","DOI":"10.1371\/journal.pgen.1002887","volume":"8","author":"L Lobel","year":"2012","unstructured":"Lobel L, Sigal N, Borovok I, Ruppin E, Herskovits AA (2012) Integrative genomic analysis identifies isoleucine and CodY as regulators of Listeria monocytogenes virulence. PLoS Genet 8:e1002887","journal-title":"PLoS Genet"},{"key":"931_CR33","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1128\/JB.184.18.5174-5178.2002","volume":"184","author":"H Ludwig","year":"2002","unstructured":"Ludwig H, Meinken C, Matin A, Stulke J (2002) Insufficient expression of the ilv-leu operon encoding enzymes of branched-chain amino acid biosynthesis limits growth of a Bacillus subtilis ccpA mutant. J Bacteriol 184:5174\u20135178","journal-title":"J Bacteriol"},{"issue":"Suppl 2","key":"931_CR34","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, Torres A, Whitney CG (2007) Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44(Suppl 2):S27\u2013S72","journal-title":"Clin Infect Dis"},{"key":"931_CR35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0168-1656(03)00145-7","volume":"104","author":"M Merkamm","year":"2003","unstructured":"Merkamm M, Chassagnole C, Lindley ND, Guyonvarch A (2003) Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum. J Biotechnol 104:253\u2013260","journal-title":"J Biotechnol"},{"key":"931_CR36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrmicro771","volume":"1","author":"TJ Mitchell","year":"2003","unstructured":"Mitchell TJ (2003) The pathogenesis of streptococcal infections: from tooth decay to meningitis. Nat Rev Microbiol 1:219\u2013230","journal-title":"Nat Rev Microbiol"},{"key":"931_CR37","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1099\/00221287-148-7-2045","volume":"148","author":"AD Ogunniyi","year":"2002","unstructured":"Ogunniyi AD, Giammarinaro P, Paton JC (2002) The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148:2045\u20132053","journal-title":"Microbiology"},{"key":"931_CR38","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1128\/IAI.00295-12","volume":"80","author":"AD Ogunniyi","year":"2012","unstructured":"Ogunniyi AD, Mahdi LK, Trappetti C, Verhoeven N, Mermans D, Van Der Hoek MB, Plumptre CD, Paton JC (2012) Identification of genes that contribute to the pathogenesis of invasive pneumococcal disease by in vivo transcriptomic analysis. Infect Immun 80:3268\u20133278","journal-title":"Infect Immun"},{"key":"931_CR39","volume-title":"Medical Microbiology","author":"JW Peterson","year":"1996","unstructured":"Peterson JW (1996) Bacterial Pathogenesis. In: Baron S (ed) Medical Microbiology, Chap 7, 4th edn. University of Texas Medical Branch, Galveston","edition":"4"},{"key":"931_CR40","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1128\/IAI.01972-06","volume":"75","author":"AM Roche","year":"2007","unstructured":"Roche AM, King SJ, Weiser JN (2007) Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice. Infect Immun 75:2469\u20132475","journal-title":"Infect Immun"},{"key":"931_CR41","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1164\/ajrccm.153.4.8616564","volume":"153","author":"JB Rubins","year":"1996","unstructured":"Rubins JB, Charboneau D, Fasching C, Berry AM, Paton JC, Alexander JE, Andrew PW, Mitchell TJ, Janoff EN (1996) Distinct roles for pneumolysin\u2019s cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. Am J Respir Crit Care Med 153:1339\u20131346","journal-title":"Am J Respir Crit Care Med"},{"key":"931_CR42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mimet.2010.08.004","volume":"83","author":"S Ruiz-Cruz","year":"2010","unstructured":"Ruiz-Cruz S, Solano-Collado V, Espinosa M, Bravo A (2010) Novel plasmid-based genetic tools for the study of promoters and terminators in Streptococcus pneumoniae and Enterococcus faecalis. J Microbiol Methods 83:156\u2013163","journal-title":"J Microbiol Methods"},{"key":"931_CR43","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1111\/j.1365-2958.2005.04634.x","volume":"56","author":"RP Shivers","year":"2005","unstructured":"Shivers RP, Sonenshein AL (2005) Bacillus subtilis ilvB operon: an intersection of global regulons. Mol Microbiol 56:1549\u20131559","journal-title":"Mol Microbiol"},{"key":"931_CR44","doi-asserted-by":"crossref","first-page":"e1000949","DOI":"10.1371\/journal.ppat.1000949","volume":"6","author":"EP Skaar","year":"2010","unstructured":"Skaar EP (2010) The battle for iron between bacterial pathogens and their vertebrate hosts. PLoS Pathog 6:e1000949","journal-title":"PLoS Pathog"},{"key":"931_CR45","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1099\/00221287-136-3-377","volume":"136","author":"H Smith","year":"1990","unstructured":"Smith H (1990) Pathogenicity and the microbe in vivo. The 1989 Fred Griffith Review Lecture. J Gen Microbiol 136:377\u2013393","journal-title":"J Gen Microbiol"},{"key":"931_CR46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/MMBR.00005-09","volume":"73","author":"GA Somerville","year":"2009","unstructured":"Somerville GA, Proctor RA (2009) At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci. Microbiol Mol Biol Rev 73:233\u2013248","journal-title":"Microbiol Mol Biol Rev"},{"key":"931_CR47","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1128\/IAI.70.11.6373-6382.2002","volume":"70","author":"GA Somerville","year":"2002","unstructured":"Somerville GA, Chaussee MS, Morgan CI, Fitzgerald JR, Dorward DW, Reitzer LJ, Musser JM (2002) Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun 70:6373\u20136382","journal-title":"Infect Immun"},{"key":"931_CR48","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.1128\/JB.185.22.6686-6694.2003","volume":"185","author":"GA Somerville","year":"2003","unstructured":"Somerville GA, Cockayne A, Durr M, Peschel A, Otto M, Musser JM (2003) Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity. J Bacteriol 185:6686\u20136694","journal-title":"J Bacteriol"},{"key":"931_CR49","doi-asserted-by":"crossref","first-page":"e1002143","DOI":"10.1371\/journal.ppat.1002143","volume":"7","author":"A Sturm","year":"2011","unstructured":"Sturm A, Heinemann M, Arnoldini M, Benecke A, Ackermann M, Benz M, Dormann J, Hardt WD (2011) The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog 7:e1002143","journal-title":"PLoS Pathog"},{"key":"931_CR50","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1128\/IAI.00671-09","volume":"77","author":"S Subashchandrabose","year":"2009","unstructured":"Subashchandrabose S, Leveque RM, Wagner TK, Kirkwood RN, Kiupel M, Mulks MH (2009) Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infect Immun 77:4925\u20134933","journal-title":"Infect Immun"},{"key":"931_CR51","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/81380","volume":"6","author":"YH Sun","year":"2000","unstructured":"Sun YH, Bakshi S, Chalmers R, Tang CM (2000) Functional genomics of Neisseria meningitidis pathogenesis. Nat Med 6:1269\u20131273","journal-title":"Nat Med"},{"key":"931_CR52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molcel.2012.08.003","volume":"48","author":"A Suraweera","year":"2012","unstructured":"Suraweera A, Munch C, Hanssum A, Bertolotti A (2012) Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell 48:242\u2013253","journal-title":"Mol Cell"},{"key":"931_CR53","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1128\/AAC.01383-10","volume":"55","author":"TD Tran","year":"2011","unstructured":"Tran TD, Kwon HY, Kim EH, Kim KW, Briles DE, Pyo S, Rhee DK (2011) Decrease in penicillin susceptibility due to heat shock protein ClpL in Streptococcus pneumoniae. Antimicrob Agents Chemother 55:2714\u20132728","journal-title":"Antimicrob Agents Chemother"},{"key":"931_CR54","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1574-695X.2006.00147.x","volume":"48","author":"TK Wagner","year":"2006","unstructured":"Wagner TK, Mulks MH (2006) A subset of Actinobacillus pleuropneumoniae in vivo induced promoters respond to branched-chain amino acid limitation. FEMS Immunol Med Microbiol 48:192\u2013204","journal-title":"FEMS Immunol Med Microbiol"},{"key":"931_CR55","doi-asserted-by":"crossref","first-page":"10434","DOI":"10.1073\/pnas.93.19.10434","volume":"93","author":"J Wang","year":"1996","unstructured":"Wang J, Mushegian A, Lory S, Jin S (1996) Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection. Proc Natl Acad Sci USA 93:10434\u201310439","journal-title":"Proc Natl Acad Sci USA"},{"key":"931_CR56","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1099\/mic.0.031799-0","volume":"156","author":"B Wu","year":"2010","unstructured":"Wu B, Zhang B, Feng X, Rubens JR, Huang R, Hicks LM, Pakrasi HB, Tang YJ (2010) Alternative isoleucine synthesis pathway in cyanobacterial species. Microbiology 156:596\u2013602","journal-title":"Microbiology"},{"key":"931_CR57","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.175.3.1813","volume":"175","author":"J Yuste","year":"2005","unstructured":"Yuste J, Botto M, Paton JC, Holden DW, Brown JS (2005) Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. J Immunol 175:1813\u20131819","journal-title":"J Immunol"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-017-0931-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-017-0931-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-017-0931-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T05:30:30Z","timestamp":1602567030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-017-0931-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,22]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["931"],"URL":"https:\/\/doi.org\/10.1007\/s12272-017-0931-0","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,22]]}}}