{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:20:33Z","timestamp":1784290833427,"version":"3.55.0"},"reference-count":172,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002636","name":"Inje University","doi-asserted-by":"publisher","award":["2016 Inje University Research Grant"],"award-info":[{"award-number":["2016 Inje University Research Grant"]}],"id":[{"id":"10.13039\/501100002636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12272-017-0998-7","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T09:56:27Z","timestamp":1512986187000},"page":"162-183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Therapeutic effects of histone deacetylase inhibitors on kidney disease"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-9880","authenticated-orcid":false,"given":"Pusoon","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"998_CR1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","volume":"9","author":"T Abbas","year":"2009","unstructured":"Abbas T, Dutta A (2009) p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9:400\u2013414","journal-title":"Nat Rev Cancer"},{"key":"998_CR2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2215\/CJN.05021107","volume":"3","author":"M Abecassis","year":"2008","unstructured":"Abecassis M, Bartlett ST, Collins AJ, Davis CL, Delmonico FL, Friedewald JJ, Hays R, Howard A, Jones E, Leichtman AB, Merion RM, Metzger RA, Pradel F, Schweitzer EJ, Velez RL, Gaston RS (2008) Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation\/Kidney Disease Outcomes Quality Initiative (NKF\/KDOQITM) conference. Clin J Am Soc Nephrol 3:471\u2013480","journal-title":"Clin J Am Soc Nephrol"},{"key":"998_CR3","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.ajpath.2011.01.044","volume":"178","author":"A Advani","year":"2011","unstructured":"Advani A, Huang Q, Thai K, Advani SL, White KE, Kelly DJ, Yuen DA, Connelly KA, Marsden PA, Gilbert RE (2011) Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. Am J Pathol 178:2205\u20132214","journal-title":"Am J Pathol"},{"key":"998_CR4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/35106036","volume":"1","author":"L Altucci","year":"2001","unstructured":"Altucci L, Gronemeyer H (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1:181\u2013193","journal-title":"Nat Rev Cancer"},{"key":"998_CR5","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1158\/1078-0432.CCR-16-2022","volume":"23","author":"JE Amengual","year":"2017","unstructured":"Amengual JE, Prabhu SA, Lombardo M, Zullo K, Johannet PM, Gonzalez Y, Scotto L, Serrano XJ, Wei Y, Duong J, Nandakumar R, Cremers S, Verma A, Elemento O, O\u2019Connor OA (2017) Mechanisms of acquired drug resistance to the HDAC6 selective inhibitor ricolinostat reveals rational drug-drug combination with ibrutinib. Clin Cancer Res 23:3084\u20133096","journal-title":"Clin Cancer Res"},{"key":"998_CR6","doi-asserted-by":"crossref","first-page":"25477","DOI":"10.1074\/jbc.M113.454850","volume":"288","author":"MB Andrawes","year":"2013","unstructured":"Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC (2013) Intrinsic selectivity of notch 1 for delta-like 4 over delta-like 1. J Biol Chem 288:25477\u201325489","journal-title":"J Biol Chem"},{"key":"998_CR7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10157-003-0259-6","volume":"7","author":"K Asanuma","year":"2003","unstructured":"Asanuma K, Mundel P (2003) The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 7:255\u2013259","journal-title":"Clin Exp Nephrol"},{"key":"998_CR8","doi-asserted-by":"crossref","first-page":"26729","DOI":"10.1074\/jbc.C500186200","volume":"280","author":"P Bali","year":"2005","unstructured":"Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 280:26729\u201326734","journal-title":"J Biol Chem"},{"key":"998_CR9","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1158\/1078-0432.CCR-11-3165","volume":"18","author":"U Banerji","year":"2012","unstructured":"Banerji U, van Doorn L, Papadatos-Pastos D, Kristeleit R, Debnam P, Tall M, Stewart A, Raynaud F, Garrett MD, Toal M, Hooftman L, De Bono JS, Verweij J, Eskens FA (2012) A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res 18:2687\u20132694","journal-title":"Clin Cancer Res"},{"key":"998_CR10","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.coi.2011.07.002","volume":"23","author":"UH Beier","year":"2011","unstructured":"Beier UH, Akimova T, Liu Y, Wang L, Hancock WW (2011) Histone\/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol 23:670\u2013678","journal-title":"Curr Opin Immunol"},{"key":"998_CR11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2337\/db08-1328","volume":"58","author":"CC Berthier","year":"2009","unstructured":"Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, Boucherot A, Neusser MA, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC, Kretzler M (2009) Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes 58:469\u2013477","journal-title":"Diabetes"},{"key":"998_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1139\/o01-032","volume":"79","author":"NR Bertos","year":"2001","unstructured":"Bertos NR, Wang AH, Yang XJ (2001) Class II histone deacetylases: structure, function, and regulation. Biochem Cell Biol 79:243\u2013252","journal-title":"Biochem Cell Biol"},{"key":"998_CR13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.ejmech.2010.02.030","volume":"45","author":"P Bertrand","year":"2010","unstructured":"Bertrand P (2010) Inside HDAC with HDAC inhibitors. Eur J Med Chem 45:2095\u20132116","journal-title":"Eur J Med Chem"},{"key":"998_CR14","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1172\/JCI43025","volume":"120","author":"B Bielesz","year":"2010","unstructured":"Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K (2010) Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 120:4040\u20134054","journal-title":"J Clin Invest"},{"key":"998_CR201","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s00467-012-2320-8","volume":"28","author":"LL Brilli","year":"2013","unstructured":"Brilli LL, Swanhart LM, de Caestecker MP, Hukriede NA (2013) HDAC inhibitors in kidney development and disease. Pediatr Nephrol 28:1909\u20131921","journal-title":"Pediatr Nephrol"},{"key":"998_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/MNH.0000000000000079","volume":"24","author":"FC Brosius 3rd","year":"2015","unstructured":"Brosius FC 3rd, He JC (2015) JAK inhibition and progressive kidney disease. Curr Opin Nephrol Hypertens 24:88\u201395","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"998_CR16","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1038\/sj.onc.1210516","volume":"26","author":"EV Broude","year":"2007","unstructured":"Broude EV, Swift ME, Vivo C, Chang BD, Davis BM, Kalurupalle S, Blagosklonny MV, Roninson IB (2007) p21(Waf1\/Cip1\/Sdi1) mediates retinoblastoma protein degradation. Oncogene 26:6954\u20136958","journal-title":"Oncogene"},{"key":"998_CR17","doi-asserted-by":"crossref","first-page":"21819","DOI":"10.1073\/pnas.0911987106","volume":"106","author":"Y Cao","year":"2009","unstructured":"Cao Y, Semanchik N, Lee SH, Somlo S, Barbano PE, Coifman R, Sun Z (2009) Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proc Natl Acad Sci USA 106:21819\u201321824","journal-title":"Proc Natl Acad Sci USA"},{"key":"998_CR18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13148-016-0224-3","volume":"8","author":"V Carafa","year":"2016","unstructured":"Carafa V, Rotili D, Forgione M, Cuomo F, Serretiello E, Hailu GS, Jarho E, Lahtela-Kakkonen M, Mai A, Altucci L (2016) Sirtuin functions and modulation: from chemistry to the clinic. Clin Epigenetics 8:61","journal-title":"Clin Epigenetics"},{"key":"998_CR19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"M Cargnello","year":"2011","unstructured":"Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75:50\u201383","journal-title":"Microbiol Mol Biol Rev"},{"key":"998_CR20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.kint.2016.01.026","volume":"90","author":"L Cebotaru","year":"2016","unstructured":"Cebotaru L, Liu Q, Yanda MK, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V (2016) Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney Int 90:90\u201399","journal-title":"Kidney Int"},{"key":"998_CR21","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1158\/1078-0432.CCR-08-1918","volume":"15","author":"TL Cha","year":"2009","unstructured":"Cha TL, Chuang MJ, Wu ST, Sun GH, Chang SY, Yu DS, Huang SM, Huan SK, Cheng TC, Chen TT, Fan PL, Hsiao PW (2009) Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells. Clin Cancer Res 15:840\u2013850","journal-title":"Clin Cancer Res"},{"key":"998_CR22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000447067","volume":"133","author":"JW Chang","year":"2016","unstructured":"Chang JW, Kim H, Baek CH, Lee RB, Yang WS, Lee SK (2016) Up-regulation of SIRT1 reduces endoplasmic reticulum stress and renal fibrosis. Nephron 133:116\u2013128","journal-title":"Nephron"},{"key":"998_CR200","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1111\/jcmm.12919","volume":"20","author":"SY Choi","year":"2016","unstructured":"Choi SY, Kee HJ, Kurz T, Hansen FK, Ryu Y, Kim GR, Lin MQ, Jin L, Piao ZH, Jeong MH (2016) Class IHDACs specifically regulate E-cadherin expression in human renal epithelial cells. J Cell Mol Med 20:2289\u20132298","journal-title":"J Cell Mol Med"},{"key":"998_CR24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.vph.2015.04.006","volume":"72","author":"SY Choi","year":"2015","unstructured":"Choi SY, Ryu Y, Kee HJ, Cho SN, Kim GR, Cho JY, Kim HS, Kim IK, Jeong MH (2015) Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes. Vascul Pharmacol 72:130\u2013140","journal-title":"Vascul Pharmacol"},{"key":"998_CR25","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s12272-015-0571-1","volume":"38","author":"P Chun","year":"2015","unstructured":"Chun P (2015) Histone deacetylase inhibitors in hematological malignancies and solid tumors. Arch Pharm Res. 38:933\u2013949","journal-title":"Arch Pharm Res."},{"key":"998_CR26","unstructured":"ClinicalTrials.gov. http:\/\/clinicaltrials.gov . Accessed 26 Oct 2017"},{"key":"998_CR27","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1158\/1535-7163.MCT-11-0873","volume":"11","author":"SJ Cooper","year":"2012","unstructured":"Cooper SJ, von Roemeling CA, Kang KH, Marlow LA, Grebe SK, Menefee ME, Tun HW, Colon-Otero G, Perez EA, Copland JA (2012) Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers. Mol Cancer Ther 11:2105\u20132115","journal-title":"Mol Cancer Ther"},{"key":"998_CR28","doi-asserted-by":"crossref","first-page":"18794","DOI":"10.1074\/jbc.M001601200","volume":"275","author":"O Coqueret","year":"2000","unstructured":"Coqueret O, Gascan H (2000) Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1\/CIP1\/SDI1. J Biol Chem 275:18794\u201318800","journal-title":"J Biol Chem"},{"key":"998_CR29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/aps.2015.79","volume":"37","author":"Q Dai","year":"2016","unstructured":"Dai Q, Liu J, Du YL, Hao X, Ying J, Tan Y, He LQ, Wang WM, Chen N (2016) Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. Acta Pharmacol Sin 37:228\u2013234","journal-title":"Acta Pharmacol Sin"},{"key":"998_CR30","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ Ruijter de","year":"2003","unstructured":"de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737\u2013749","journal-title":"Biochem J"},{"key":"998_CR31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/JOE-16-0322","volume":"232","author":"W Dong","year":"2017","unstructured":"Dong W, Jia Y, Liu X, Zhang H, Li T, Huang W, Chen X, Wang F, Sun W, Wu H (2017) Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. J Endocrinol 232:71\u201383","journal-title":"J Endocrinol"},{"key":"998_CR32","unstructured":"Drugs@FDA. http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\/index.cfm . Accessed 26 Oct 2017"},{"key":"998_CR33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ki.2011.296","volume":"81","author":"LX Fan","year":"2012","unstructured":"Fan LX, Li X, Magenheimer B, Calvet JP, Li X (2012) Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. Kidney Int 81:76\u201385","journal-title":"Kidney Int"},{"key":"998_CR34","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1074\/jbc.M600456200","volume":"281","author":"DM Fath","year":"2006","unstructured":"Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y, Fang J, Caro J, Sang N (2006) Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem 281:13612\u201313619","journal-title":"J Biol Chem"},{"key":"998_CR35","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1158\/1535-7163.MCT-07-2026","volume":"7","author":"M Fournel","year":"2008","unstructured":"Fournel M, Bonfils C, Hou Y, Yan PT, Trachy-Bourget MC, Kalita A, Liu J, Lu AH, Zhou NZ, Robert MF, Gillespie J, Wang JJ, Ste-Croix H, Rahil J, Lefebvre S, Moradei O, Delorme D, Macleod AR, Besterman JM, Li Z (2008) MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 7:759\u2013768","journal-title":"Mol Cancer Ther"},{"key":"998_CR36","doi-asserted-by":"crossref","first-page":"F426","DOI":"10.1152\/ajprenal.00107.2009","volume":"298","author":"I Freidkin","year":"2010","unstructured":"Freidkin I, Herman M, Tobar A, Chagnac A, Ori Y, Korzets A, Gafter U (2010) Effects of histone deacetylase inhibitors on rat mesangial cells. Am J Physiol Renal Physiol 298:F426\u2013F434","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/1471-2407-8-381","volume":"8","author":"FR Fritzsche","year":"2008","unstructured":"Fritzsche FR, Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, Scholman K, Denkert C, Dietel M, Kristiansen G (2008) Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer. BMC Cancer 8:381","journal-title":"BMC Cancer"},{"key":"998_CR38","doi-asserted-by":"crossref","first-page":"25748","DOI":"10.1074\/jbc.M111871200","volume":"277","author":"L Gao","year":"2002","unstructured":"Gao L, Cueto MA, Asselbergs F, Atadja P (2002) Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277:25748\u201325755","journal-title":"J Biol Chem"},{"key":"998_CR39","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/ki.2011.39","volume":"79","author":"RE Gilbert","year":"2011","unstructured":"Gilbert RE, Huang Q, Thai K, Advani SL, Lee K, Yuen DA, Connelly KA, Advani A (2011) Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor. Kidney Int 79:1312\u20131321","journal-title":"Kidney Int"},{"key":"998_CR40","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3389\/fphys.2017.00829","volume":"8","author":"K Grynberg","year":"2017","unstructured":"Grynberg K, Ma FY, Nikolic-Paterson DJ (2017) The JNK signaling pathway in renal fibrosis. Front Physiol 8:829","journal-title":"Front Physiol"},{"key":"998_CR41","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1158\/1078-0432.CCR-07-0143","volume":"13","author":"ML Gumz","year":"2007","unstructured":"Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA (2007) Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 13:4740\u20134749","journal-title":"Clin Cancer Res"},{"key":"998_CR42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","volume":"10","author":"M Haberland","year":"2009","unstructured":"Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:32\u201342","journal-title":"Nat Rev Genet"},{"key":"998_CR43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/07357907.2011.590568","volume":"29","author":"JD Hainsworth","year":"2011","unstructured":"Hainsworth JD, Infante JR, Spigel DR, Arrowsmith ER, Boccia RV, Burris HA (2011) A phase II trial of panobinostat, a histone deacetylase inhibitor, in the treatment of patients with refractory metastatic renal cell carcinoma. Cancer Invest 29:451\u2013455","journal-title":"Cancer Invest"},{"key":"998_CR44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2008.04.176","volume":"372","author":"K Hasegawa","year":"2008","unstructured":"Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Washida N, Tokuyama H, Hayashi K, Itoh H (2008) Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem Biophys Res Commun 372:51\u201356","journal-title":"Biochem Biophys Res Commun"},{"key":"998_CR45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","volume":"12","author":"B Hoesel","year":"2013","unstructured":"Hoesel B, Schmid JA (2013) The complexity of NF-\u03baB signaling in inflammation and cancer. Mol Cancer 12:86","journal-title":"Mol Cancer"},{"key":"998_CR46","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"S Hori","year":"2003","unstructured":"Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057\u20131061","journal-title":"Science"},{"key":"998_CR47","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.ajkd.2015.01.026","volume":"65","author":"DE Hricik","year":"2015","unstructured":"Hricik DE (2015) Transplant immunology and immunosuppression: core curriculum 2015. Am J Kidney Dis 65:956\u2013966","journal-title":"Am J Kidney Dis"},{"key":"998_CR48","doi-asserted-by":"crossref","first-page":"F1443","DOI":"10.1152\/ajprenal.00143.2012","volume":"303","author":"CH Hsing","year":"2012","unstructured":"Hsing CH, Lin CF, So E, Sun DP, Chen TC, Li CF, Yeh CH (2012) \u03b12-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol 303:F1443\u2013F1453","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR202","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.18632\/aging.101214","volume":"9","author":"W Huang","year":"2017","unstructured":"Huang W, Liu H, Zhu S, Woodson M, Liu R, Tilton RG, Miller JD, Zhang W (2017) Sirt6 deficiency results in progression of glomerular injury in the kidney. Aging (Albany NY) 9:1069\u20131083","journal-title":"Aging (Albany NY)"},{"key":"998_CR49","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","volume":"13","author":"P Igarashi","year":"2002","unstructured":"Igarashi P, Somlo S (2002) Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 13:2384\u20132398","journal-title":"J Am Soc Nephrol"},{"key":"998_CR50","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1634\/stemcells.2007-0049","volume":"25","author":"N Imai","year":"2007","unstructured":"Imai N, Hishikawa K, Marumo T, Hirahashi J, Inowa T, Matsuzaki Y, Okano H, Kitamura T, Salant D, Fujita T (2007) Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. Stem Cells 25:2469\u20132475","journal-title":"Stem Cells"},{"key":"998_CR51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcp.10208","volume":"194","author":"T Iso","year":"2003","unstructured":"Iso T, Kedes L, Hamamori Y (2003) HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 194:237\u2013255","journal-title":"J Cell Physiol"},{"key":"998_CR52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3727\/096504016X14666990347635","volume":"24","author":"M Isono","year":"2016","unstructured":"Isono M, Sato A, Okubo K, Asano T, Asano T (2016) Ritonavir interacts with belinostat to cause endoplasmic reticulum stress and histone acetylation in renal cancer cells. Oncol Res 24:327\u2013335","journal-title":"Oncol Res"},{"key":"998_CR53","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/1947601910397187","volume":"1","author":"SS Jatiani","year":"2010","unstructured":"Jatiani SS, Baker SJ, Silverman LR, Reddy EP (2010) Jak\/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies. Genes Cancer 1:979\u2013993","journal-title":"Genes Cancer"},{"key":"998_CR54","first-page":"363","volume":"12","author":"BH Jiang","year":"2001","unstructured":"Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK (2001) Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12:363\u2013369","journal-title":"Cell Growth Differ"},{"key":"998_CR55","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1111\/j.1582-4934.2008.00436.x","volume":"13","author":"J Jones","year":"2009","unstructured":"Jones J, Juengel E, Mickuckyte A, Hudak L, Wedel S, Jonas D, Blaheta RA (2009) The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo. J Cell Mol Med 13:2376\u20132385","journal-title":"J Cell Mol Med"},{"key":"998_CR56","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1464-410X.2009.08759.x","volume":"105","author":"E Juengel","year":"2010","unstructured":"Juengel E, Engler J, Mickuckyte A, Jones J, Hudak L, Jonas D, Blaheta RA (2010) Effects of combined valproic acid and the epidermal growth factor\/vascular endothelial growth factor receptor tyrosine kinase inhibitor AEE788 on renal cell carcinoma cell lines in vitro. BJU Int 105:549\u2013557","journal-title":"BJU Int"},{"key":"998_CR57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.canlet.2012.05.003","volume":"324","author":"E Juengel","year":"2012","unstructured":"Juengel E, Dauselt A, Makarevi\u0107 J, Wiesner C, Tsaur I, Bartsch G, Haferkamp A, Blaheta RA (2012) Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells. Cancer Lett 324:83\u201390","journal-title":"Cancer Lett"},{"key":"998_CR58","doi-asserted-by":"crossref","first-page":"e53100","DOI":"10.1371\/journal.pone.0053100","volume":"8","author":"E Juengel","year":"2013","unstructured":"Juengel E, Makarevi\u0107 J, Tsaur I, Bartsch G, Nelson K, Haferkamp A, Blaheta RA (2013) Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo. PLoS ONE 8:e53100","journal-title":"PLoS ONE"},{"key":"998_CR59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.intimp.2016.11.008","volume":"42","author":"SW Kang","year":"2017","unstructured":"Kang SW, Lee SM, Kim JY, Kim SY, Kim YH, Kim TH, Kang MS, Jang WH, Seo SK (2017) Therapeutic activity of the histone deacetylase inhibitor SB939 on renal fibrosis. Int Immunopharmacol 42:25\u201331","journal-title":"Int Immunopharmacol"},{"key":"998_CR60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng1279","volume":"36","author":"H Katayama","year":"2004","unstructured":"Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S (2004) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 36:55\u201362","journal-title":"Nat Genet"},{"key":"998_CR61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fct.2014.08.010","volume":"73","author":"S Khan","year":"2014","unstructured":"Khan S, Jena G (2014) Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-\u03b21-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food Chem Toxicol 73:127\u2013139","journal-title":"Food Chem Toxicol"},{"key":"998_CR62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2014.12.015","volume":"110","author":"S Khan","year":"2015","unstructured":"Khan S, Jena G, Tikoo K, Kumar V (2015a) Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-\u03baB\/iNOS signaling in diabetic rat. Biochimie 110:1\u201316","journal-title":"Biochimie"},{"key":"998_CR63","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.yexmp.2015.01.003","volume":"98","author":"S Khan","year":"2015","unstructured":"Khan S, Jena G, Tikoo K (2015b) Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat. Exp Mol Pathol 98:230\u2013239","journal-title":"Exp Mol Pathol"},{"key":"998_CR203","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3892\/ijo.2013.2163","volume":"44","author":"MK Kim","year":"2014","unstructured":"Kim MK, Kang YJ, Kim DH, Hossain MA, Jang JY, Lee SH, Yoon JH, Chun P, Moon HR, Kim HS, Chung HY, Kim ND (2014) A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-\u03baB in HCT116 human colon cancer cells. Int J Oncol 44:256\u2013264","journal-title":"Int J Oncol"},{"key":"998_CR64","first-page":"3161","volume":"32","author":"MJ Kim","year":"2012","unstructured":"Kim MJ, Kim DE, Jeong IG, Choi J, Jang S, Lee JH, Ro S, Hwang JJ, Kim CS (2012) HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells. Anticancer Res 32:3161\u20133168","journal-title":"Anticancer Res"},{"key":"998_CR65","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.trim.2009.04.006","volume":"21","author":"F Kinugasa","year":"2009","unstructured":"Kinugasa F, Nagatomi I, Nakanishi T, Noto T, Mori H, Matsuoka H, Sudo Y, Mutoh S (2009) Effect of the immunosuppressant histone deacetylase inhibitor FR276457 in a canine renal transplant model. Transpl Immunol 21:198\u2013202","journal-title":"Transpl Immunol"},{"key":"998_CR66","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trim.2010.02.003","volume":"23","author":"F Kinugasa","year":"2010","unstructured":"Kinugasa F, Noto T, Matsuoka H, Urano Y, Sudo Y, Takakura S, Mutoh S (2010) Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction. Transpl Immunol 23:18\u201323","journal-title":"Transpl Immunol"},{"key":"998_CR67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","volume":"285","author":"T Kisseleva","year":"2002","unstructured":"Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002) Signaling through the JAK\/STAT pathway, recent advances and future challenges. Gene 285:1\u201324","journal-title":"Gene"},{"key":"998_CR68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","volume":"6","author":"LO Klotz","year":"2015","unstructured":"Klotz LO, S\u00e1nchez-Ramos C, Prieto-Arroyo I, Urb\u00e1nek P, Steinbrenner H, Monsalve M (2015) Redox regulation of FoxO transcription factors. Redox Biol 6:51\u201372","journal-title":"Redox Biol"},{"key":"998_CR69","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/ki.2008.74","volume":"73","author":"T Kobayashi","year":"2008","unstructured":"Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S (2008) Expression and function of the Delta-1\/Notch-2\/Hes-1 pathway during experimental acute kidney injury. Kidney Int 73:1240\u20131250","journal-title":"Kidney Int"},{"key":"998_CR70","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","volume":"4","author":"Y Komiya","year":"2008","unstructured":"Komiya Y, Habas R (2008) Wnt signal transduction pathways. Organogenesis 4:68\u201375","journal-title":"Organogenesis"},{"key":"998_CR71","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","volume":"18","author":"JJ Kovacs","year":"2005","unstructured":"Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18:601\u2013607","journal-title":"Mol Cell"},{"key":"998_CR72","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1074\/jbc.M114.555060","volume":"289","author":"G Kumari","year":"2014","unstructured":"Kumari G, Ulrich T, Krause M, Finkernagel F, Gaubatz S (2014) Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species. J Biol Chem 289:16072\u201316084","journal-title":"J Biol Chem"},{"key":"998_CR73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1074\/jbc.M605904200","volume":"282","author":"S Kume","year":"2007","unstructured":"Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem 282:151\u2013158","journal-title":"J Biol Chem"},{"key":"998_CR74","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1248\/bpb.32.1723","volume":"32","author":"HK Kwon","year":"2009","unstructured":"Kwon HK, Ahn SH, Park SH, Park JH, Park JW, Kim HM, Park SK, Lee K, Lee CW, Choi E, Han G, Han JW (2009) A novel gamma-lactam-based histone deacetylase inhibitor potently inhibits the growth of human breast and renal cancer cells. Biol Pharm Bull 32:1723\u20131727","journal-title":"Biol Pharm Bull"},{"key":"998_CR75","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ndt\/gfu196","volume":"30","author":"A Lan","year":"2015","unstructured":"Lan A, Du J (2015) Potential role of Akt signaling in chronic kidney disease. Nephrol Dial Transplant 30:385\u2013394","journal-title":"Nephrol Dial Transplant"},{"key":"998_CR76","doi-asserted-by":"crossref","first-page":"20534","DOI":"10.1074\/jbc.M611782200","volume":"282","author":"SC Land","year":"2007","unstructured":"Land SC, Tee AR (2007) Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 282:20534\u201320543","journal-title":"J Biol Chem"},{"key":"998_CR77","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149:274\u2013293","journal-title":"Cell"},{"key":"998_CR78","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.trsl.2014.07.010","volume":"165","author":"SY Lee","year":"2015","unstructured":"Lee SY, Kim SI, Choi ME (2015) Therapeutic targets for treating fibrotic kidney diseases. Transl Res 165:512\u2013530","journal-title":"Transl Res"},{"key":"998_CR79","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/ajt.13106","volume":"15","author":"MH Levine","year":"2015","unstructured":"Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW (2015) Class-specific histone\/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation. Am J Transplant 15:965\u2013973","journal-title":"Am J Transplant"},{"key":"998_CR80","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.kint.2015.12.051","volume":"89","author":"MH Levine","year":"2016","unstructured":"Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH (2016) Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int 89:1016\u20131026","journal-title":"Kidney Int"},{"key":"998_CR81","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1681\/ASN.2013050527","volume":"25","author":"CL Lin","year":"2014","unstructured":"Lin CL, Lee PH, Hsu YC, Lei CC, Ko JY, Chuang PC, Huang YT, Wang SY, Wu SL, Chen YS, Chiang WC, Reiser J, Wang FS (2014) MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. J Am Soc Nephrol 25:1698\u20131709","journal-title":"J Am Soc Nephrol"},{"key":"998_CR82","doi-asserted-by":"crossref","first-page":"52175","DOI":"10.1074\/jbc.M406802200","volume":"279","author":"Q Liu","year":"2004","unstructured":"Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ (2004) Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem 279:52175\u201352182","journal-title":"J Biol Chem"},{"key":"998_CR83","doi-asserted-by":"crossref","first-page":"29168","DOI":"10.1074\/jbc.M112.371120","volume":"287","author":"Y Liu","year":"2012","unstructured":"Liu Y, Peng L, Seto E, Huang S, Qiu Y (2012a) Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem 287:29168\u201329174","journal-title":"J Biol Chem"},{"key":"998_CR84","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1681\/ASN.2011050493","volume":"23","author":"N Liu","year":"2012","unstructured":"Liu N, Guo JK, Pang M, Tolbert E, Ponnusamy M, Gong R, Bayliss G, Dworkin LD, Yan H, Zhuang S (2012b) Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol 23:854\u2013867","journal-title":"J Am Soc Nephrol"},{"key":"998_CR85","doi-asserted-by":"crossref","first-page":"e54001","DOI":"10.1371\/journal.pone.0054001","volume":"8","author":"N Liu","year":"2013","unstructured":"Liu N, He S, Ma L, Ponnusamy M, Tang J, Tolbert E, Bayliss G, Zhao TC, Yan H, Zhuang S (2013) Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS ONE 8:e54001","journal-title":"PLoS ONE"},{"key":"998_CR86","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.2337\/db13-1810","volume":"63","author":"R Liu","year":"2014","unstructured":"Liu R, Zhong Y, Li X, Chen H, Jim B, Zhou MM, Chuang PY, He JC (2014) Role of transcription factor acetylation in diabetic kidney disease. Diabetes 63:2440\u20132453","journal-title":"Diabetes"},{"key":"998_CR87","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/jcmm.13060","volume":"21","author":"M Liu","year":"2017","unstructured":"Liu M, Ning X, Li R, Yang Z, Yang X, Sun S, Qian Q (2017) Signalling pathways involved in hypoxia-induced renal fibrosis. J Cell Mol Med 21:1248\u20131259","journal-title":"J Cell Mol Med"},{"issue":"Suppl 1","key":"998_CR88","doi-asserted-by":"crossref","first-page":"i37","DOI":"10.1093\/ndt\/gft267","volume":"29","author":"I Loeffler","year":"2014","unstructured":"Loeffler I, Wolf G (2014) Transforming growth factor-\u03b2 and the progression of renal disease. Nephrol Dial Transplant 29(Suppl 1):i37\u2013i45","journal-title":"Nephrol Dial Transplant"},{"key":"998_CR89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ki.2009.98","volume":"76","author":"TC Lu","year":"2009","unstructured":"Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, Levy DE, Xiong H, Chen N, He JC (2009) Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int 76:63\u201371","journal-title":"Kidney Int"},{"key":"998_CR90","doi-asserted-by":"crossref","first-page":"e3139","DOI":"10.1038\/cddis.2017.552","volume":"8","author":"T Ma","year":"2017","unstructured":"Ma T, Huang C, Xu Q, Yang Y, Liu Y, Meng X, Li J, Ye M, Liang H (2017) Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. Cell Death Dis 8:e3139","journal-title":"Cell Death Dis"},{"key":"998_CR91","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","volume":"17","author":"BT MacDonald","year":"2009","unstructured":"MacDonald BT, Tamai K, He X (2009) Wnt\/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17:9\u201326","journal-title":"Dev Cell"},{"key":"998_CR92","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1158\/1078-0432.CCR-09-1385","volume":"16","author":"D Mahalingam","year":"2010","unstructured":"Mahalingam D, Medina EC, Esquivel JA 2nd, Espitia CM, Smith S, Oberheu K, Swords R, Kelly KR, Mita MM, Mita AC, Carew JS, Giles FJ, Nawrocki ST (2010) Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels. Clin Cancer Res 16:141\u2013153","journal-title":"Clin Cancer Res"},{"key":"998_CR93","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.juro.2013.06.110","volume":"191","author":"SR Manson","year":"2014","unstructured":"Manson SR, Song JB, Hruska KA, Austin PF (2014) HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-\u03b2 mediated renal fibrosis in obstructive uropathy. J Urol 191:242\u2013252","journal-title":"J Urol"},{"key":"998_CR94","doi-asserted-by":"crossref","first-page":"F133","DOI":"10.1152\/ajprenal.00400.2009","volume":"298","author":"T Marumo","year":"2010","unstructured":"Marumo T, Hishikawa K, Yoshikawa M, Hirahashi J, Kawachi S, Fujita T (2010) Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. Am J Physiol Renal Physiol 298:F133\u2013141","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR95","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","volume":"12","author":"XM Meng","year":"2016","unstructured":"Meng XM, Nikolic-Paterson DJ, Lan HY (2016) TGF-\u03b2: the master regulator of fibrosis. Nat Rev Nephrol 12:325\u2013338","journal-title":"Nat Rev Nephrol"},{"key":"998_CR96","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.E05-01-0033","volume":"16","author":"E Michishita","year":"2005","unstructured":"Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 16:4623\u20134635","journal-title":"Mol Biol Cell"},{"key":"998_CR97","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4161\/cbt.3.6.846","volume":"3","author":"EG Mimnaugh","year":"2004","unstructured":"Mimnaugh EG, Xu W, Vos M, Yuan X, Isaacs JS, Bisht KS, Gius D, Neckers L (2004) Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol Cancer Ther 3:551\u2013566","journal-title":"Mol Cancer Ther"},{"key":"998_CR98","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI16153","volume":"111","author":"N Mishra","year":"2003","unstructured":"Mishra N, Reilly CM, Brown DR, Ruiz P, Gilkeson GS (2003) Histone deacetylase inhibitors modulate renal disease in the MRL-lpr\/lpr mouse. J Clin Invest 111:539\u2013552","journal-title":"J Clin Invest"},{"key":"998_CR99","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1158\/1078-0432.CCR-08-0746","volume":"14","author":"AC Mita","year":"2008","unstructured":"Mita AC, Mita MM, Nawrocki ST, Giles FJ (2008) Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 14:5000\u20135005","journal-title":"Clin Cancer Res"},{"key":"998_CR100","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2215\/CJN.04800908","volume":"4","author":"M Naesens","year":"2009","unstructured":"Naesens M, Kuypers DR, Sarwal M (2009) Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 4:481\u2013508","journal-title":"Clin J Am Soc Nephrol"},{"key":"998_CR101","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3218","author":"T Nguy\u1ec5n-Thanh","year":"2017","unstructured":"Nguy\u1ec5n-Thanh T, Kim D, Lee S, Kim W, Park SK, Kang KP (2017) Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice. Int J Mol Med. https:\/\/doi.org\/10.3892\/ijmm.2017.3218","journal-title":"Int J Mol Med"},{"key":"998_CR102","doi-asserted-by":"crossref","first-page":"F729","DOI":"10.1152\/ajprenal.00086.2009","volume":"297","author":"H Noh","year":"2009","unstructured":"Noh H, Oh EY, Seo JY, Yu MR, Kim YO, Ha H, Lee HB (2009) Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Am J Physiol Renal Physiol 297:F729\u2013F739","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR103","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/j.1523-1755.2002.kid583.x","volume":"62","author":"T Okado","year":"2002","unstructured":"Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S (2002) Smad7 mediates transforming growth factor-b-induced apoptosis in mesangial cells. Kidney Int 62:1178\u20131186","journal-title":"Kidney Int"},{"key":"998_CR104","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.cellsig.2014.02.017","volume":"26","author":"JM Overstreet","year":"2014","unstructured":"Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ (2014) Redox control of p53 in the transcriptional regulation of TGF-\u03b21 target genes through SMAD cooperativity. Cell Signal 26:1427\u20131436","journal-title":"Cell Signal"},{"key":"998_CR105","doi-asserted-by":"crossref","first-page":"F996","DOI":"10.1152\/ajprenal.00282.2009","volume":"297","author":"M Pang","year":"2009","unstructured":"Pang M, Kothapally J, Mao H, Tolbert E, Ponnusamy M, Chin YE, Zhuang S (2009) Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 297:F996\u2013F1005","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR106","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/jcb.23135","volume":"112","author":"M Pang","year":"2011","unstructured":"Pang M, Ma L, Liu N, Ponnusamy M, Zhao TC, Yan H, Zhuang S (2011) Histone deacetylase 1\/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J Cell Biochem 112:2138\u20132148","journal-title":"J Cell Biochem"},{"key":"998_CR107","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12974-016-0765-6","volume":"13","author":"MJ Park","year":"2016","unstructured":"Park MJ, Sohrabji F (2016) The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflammation 13:300","journal-title":"J Neuroinflammation"},{"key":"998_CR108","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1158\/1078-0432.CCR-03-0709","volume":"10","author":"JH Park","year":"2004","unstructured":"Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK, Lee JS, Kim NK, Kim TY, Bang YJ (2004) Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res 10:5271\u20135281","journal-title":"Clin Cancer Res"},{"key":"998_CR109","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bbamcr.2010.12.012","volume":"1813","author":"A Plotnikov","year":"2011","unstructured":"Plotnikov A, Zehorai E, Procaccia S, Seger R (2011) The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim Biophys Acta 1813:1619\u20131633","journal-title":"Biochim Biophys Acta"},{"key":"998_CR110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/jpet.113.212076","volume":"350","author":"M Ponnusamy","year":"2014","unstructured":"Ponnusamy M, Zhou X, Yan Y, Tang J, Tolbert E, Zhao TC, Gong R, Zhuang S (2014) Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J Pharmacol Exp Ther 350:243\u2013256","journal-title":"J Pharmacol Exp Ther"},{"key":"998_CR111","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2337\/db08-0061","volume":"57","author":"Y Qian","year":"2008","unstructured":"Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC 3rd (2008) From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes 57:1439\u20131445","journal-title":"Diabetes"},{"key":"998_CR112","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/ki.2015.326","volume":"89","author":"P Ranganathan","year":"2016","unstructured":"Ranganathan P, Hamad R, Mohamed R, Jayakumar C, Muthusamy T, Ramesh G (2016) Histone deacetylase\u2013mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. Kidney Int 89:317\u2013326","journal-title":"Kidney Int"},{"key":"998_CR113","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","volume":"74","author":"I Raphael","year":"2015","unstructured":"Raphael I, Nalawade S, Eagar TN, Forsthuber TG (2015) T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 74:5\u201317","journal-title":"Cytokine"},{"key":"998_CR114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clim.2014.01.002","volume":"151","author":"NL Regna","year":"2014","unstructured":"Regna NL, Chafin CB, Hammond SE, Puthiyaveetil AG, Caudell DL, Reilly CM (2014) Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo. Clin Immunol 151:29\u201342","journal-title":"Clin Immunol"},{"key":"998_CR115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clim.2015.11.007","volume":"162","author":"NL Regna","year":"2016","unstructured":"Regna NL, Vieson MD, Luo XM, Chafin CB, Puthiyaveetil AG, Hammond SE, Caudell DL, Jarpe MB, Reilly CM (2016) Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB\/W mice. Clin Immunol 162:58\u201373","journal-title":"Clin Immunol"},{"key":"998_CR116","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13046","author":"J Ren","year":"2017","unstructured":"Ren J, Liao X, Vieson MD, Chen M, Scott R, Kazmierczak J, Luo XM, Reilly CM (2017) Selective HDAC6 inhibition decreases early stage of lupus nephritis by down-regulating both innate and adaptive immune responses. Clin Exp Immunol. https:\/\/doi.org\/10.1111\/cei.13046","journal-title":"Clin Exp Immunol"},{"key":"998_CR117","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"998_CR118","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","volume":"66","author":"R Roskoski Jr","year":"2012","unstructured":"Roskoski R Jr (2012) ERK1\/2 MAP kinases: structure, function, and regulation. Pharmacol Res 66:105\u2013143","journal-title":"Pharmacol Res"},{"key":"998_CR119","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.canlet.2006.03.007","volume":"244","author":"NK Sah","year":"2006","unstructured":"Sah NK, Khan Z, Khan GJ, Bisen PS (2006) Structural, functional and therapeutic biology of survivin. Cancer Lett 244:164\u2013171","journal-title":"Cancer Lett"},{"key":"998_CR120","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.cellsig.2013.07.007","volume":"25","author":"R Samarakoon","year":"2013","unstructured":"Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ (2013a) Induction of renal fibrotic genes by TGF-\u03b21 requires EGFR activation, p53 and reactive oxygen species. Cell Signal 25:2198\u20132209","journal-title":"Cell Signal"},{"key":"998_CR121","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cellsig.2012.10.003","volume":"25","author":"R Samarakoon","year":"2013","unstructured":"Samarakoon R, Overstreet JM, Higgins PJ (2013b) TGF-\u03b2 signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal 25:264\u2013268","journal-title":"Cell Signal"},{"issue":"8","key":"998_CR122","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1681\/ASN.2010020218","volume":"21","author":"AB Sanz","year":"2010","unstructured":"Sanz AB, Sanchez-Ni\u00f1o MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, Egido J, Ortiz A (2010) NF-kappaB in renal inflammation. J Am Soc Nephrol 21(8):1254\u20131262","journal-title":"J Am Soc Nephrol"},{"key":"998_CR123","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molcel.2011.04.029","volume":"43","author":"S Sarkar","year":"2011","unstructured":"Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O\u2019Kane CJ, Rubinsztein DC (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43:19\u201332","journal-title":"Mol Cell"},{"key":"998_CR124","doi-asserted-by":"crossref","first-page":"764.e7","DOI":"10.1016\/j.urology.2010.04.042","volume":"76","author":"A Sato","year":"2010","unstructured":"Sato A, Asano T, Horiguchi A, Ito K, Sumitomo M, Asano T (2010) Combination of suberoylanilide hydroxamic acid and ritonavir is effective against renal cancer cells. Urology 76:764.e7\u2013764.e13","journal-title":"Urology"},{"key":"998_CR125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3727\/096504011X12970940207841","volume":"19","author":"A Sato","year":"2011","unstructured":"Sato A, Asano T, Horiguchi A, Ito K, Sumitomo M, Asano T (2011) Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells. Oncol Res 19:217\u2013223","journal-title":"Oncol Res"},{"key":"998_CR126","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1464-410X.2011.10533.x","volume":"109","author":"A Sato","year":"2012","unstructured":"Sato A, Asano T, Ito K, Sumitomo M, Asano T (2012) Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically. BJU Int 109:1258\u20131268","journal-title":"BJU Int"},{"key":"998_CR127","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1471-2490-14-71","volume":"14","author":"A Sato","year":"2014","unstructured":"Sato A, Asano T, Isono M, Ito K, Asano T (2014) Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells. BMC Urol 14:71","journal-title":"BMC Urol"},{"key":"998_CR128","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-62703-236-0_4","volume":"962","author":"E Senturk","year":"2013","unstructured":"Senturk E, Manfredi JJ (2013) p53 and cell cycle effects after DNA damage. Methods Mol Biol 962:49\u201361","journal-title":"Methods Mol Biol"},{"key":"998_CR129","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MNH.0b013e3283414c88","volume":"20","author":"S Sharma","year":"2011","unstructured":"Sharma S, Sirin Y, Susztak K (2011) The story of Notch and chronic kidney disease. Curr Opin Nephrol Hypertens 20:56\u201361","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"998_CR130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13045-017-0439-6","volume":"10","author":"Y Shi","year":"2017","unstructured":"Shi Y, Jia B, Xu W, Li W, Liu T, Liu P, Zhao W, Zhang H, Sun X, Yang H, Zhang X, Jin J, Jin Z, Li Z, Qiu L, Dong M, Huang X, Luo Y, Wang X, Wang X, Wu J, Xu J, Yi P, Zhou J, He H, Liu L, Shen J, Tang X, Wang J, Yang J, Zeng Q, Zhang Z, Cai Z, Chen X, Ding K, Hou M, Huang H, Li X, Liang R, Liu Q, Song Y, Su H, Gao Y, Liu L, Luo J, Su L, Sun Z, Tan H, Wang H, Wang J, Wang S, Zhang H, Zhang X, Zhou D, Bai O, Wu G, Zhang L, Zhang Y (2017a) Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China. J Hematol Oncol. 10:69","journal-title":"J Hematol Oncol."},{"key":"998_CR131","doi-asserted-by":"crossref","first-page":"F502","DOI":"10.1152\/ajprenal.00546.2016","volume":"312","author":"Y Shi","year":"2017","unstructured":"Shi Y, Xu L, Tang J, Fang L, Ma S, Ma X, Nie J, Pi X, Qiu A, Zhuang S, Liu N (2017b) Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury. Am J Physiol Renal Physiol 312:F502\u2013F515","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR132","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1586\/era.10.62","volume":"10","author":"BN Singh","year":"2010","unstructured":"Singh BN, Zhang G, Hwa YL, Li J, Dowdy SC, Jiang SW (2010) Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther 10:935\u2013954","journal-title":"Expert Rev Anticancer Ther"},{"key":"998_CR133","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3816\/CGC.2006.n.018","volume":"5","author":"WM Stadler","year":"2006","unstructured":"Stadler WM, Margolin K, Ferber S, McCulloch W, Thompson JA (2006) A phase II study of depsipeptide in refractory metastatic renal cell cancer. Clin Genitourin Cancer. 5:57\u201360","journal-title":"Clin Genitourin Cancer."},{"key":"998_CR134","doi-asserted-by":"crossref","first-page":"F596","DOI":"10.1152\/ajprenal.00365.2015","volume":"310","author":"A Sureshbabu","year":"2016","unstructured":"Sureshbabu A, Muhsin SA, Choi ME (2016) TGF-\u03b2 signaling in the kidney: profibrotic and protective effects. Am J Physiol Renal Physiol 310:F596\u2013F606","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR135","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9440(10)64554-3","volume":"157","author":"KL Talks","year":"2000","unstructured":"Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411\u2013421","journal-title":"Am J Pathol"},{"key":"998_CR136","doi-asserted-by":"crossref","first-page":"a015552","DOI":"10.1101\/cshperspect.a015552","volume":"3","author":"Q Tang","year":"2013","unstructured":"Tang Q, Bluestone JA (2013) Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med. 3:a015552","journal-title":"Cold Spring Harb Perspect Med."},{"key":"998_CR137","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","volume":"6","author":"XH Tang","year":"2011","unstructured":"Tang XH, Gudas LJ (2011) Retinoids, retinoic acid receptors, and cancer. Annu Rev Pathol 6:345\u2013364","journal-title":"Annu Rev Pathol"},{"key":"998_CR138","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/ki.2012.435","volume":"83","author":"J Tang","year":"2013","unstructured":"Tang J, Liu N, Zhuang S (2013) Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int 83:804\u2013810","journal-title":"Kidney Int"},{"key":"998_CR139","doi-asserted-by":"crossref","first-page":"F303","DOI":"10.1152\/ajprenal.00102.2014","volume":"307","author":"J Tang","year":"2014","unstructured":"Tang J, Yan Y, Zhao TC, Gong R, Bayliss G, Yan H, Zhuang S (2014) Class I HDAC activity is required for renal protection and regeneration after acute kidney injury. Am J Physiol Renal Physiol 307:F303\u2013F316","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR140","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1158\/1078-0432.CCR-04-1155","volume":"11","author":"SE Touma","year":"2005","unstructured":"Touma SE, Goldberg JS, Moench P, Guo X, Tickoo SK, Gudas LJ, Nanus DM (2005) Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Cancer Res 11:3558\u20133566","journal-title":"Clin Cancer Res"},{"key":"998_CR141","doi-asserted-by":"crossref","first-page":"14495","DOI":"10.1038\/s41598-017-15162-6","volume":"7","author":"CW Tung","year":"2017","unstructured":"Tung CW, Hsu YC, Cai CJ, Shih YH, Wang CJ, Chang PJ, Lin CL (2017) Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway. Sci Rep 7:14495","journal-title":"Sci Rep"},{"issue":"11","key":"998_CR142","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","volume":"1843","author":"MD Turner","year":"2014","unstructured":"Turner MD, Nedjai B, Hurst T (2014) Pennington DJ (2014) Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta 1843(11):2563\u20132582","journal-title":"Biochim Biophys Acta"},{"key":"998_CR143","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.taap.2013.05.013","volume":"271","author":"K Beneden Van","year":"2013","unstructured":"Van Beneden K, Geers C, Pauwels M, Mannaerts I, Wissing KM, Van den Branden C, van Grunsven LA (2013) Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. Toxicol Appl Pharmacol 271:276\u2013284","journal-title":"Toxicol Appl Pharmacol"},{"key":"998_CR144","doi-asserted-by":"crossref","first-page":"e51842","DOI":"10.1371\/journal.pone.0051842","volume":"8","author":"M Veerasamy","year":"2013","unstructured":"Veerasamy M, Phanish M, Dockrell ME (2013) Smad mediated regulation of inhibitor of DNA binding 2 and its role in phenotypic maintenance of human renal proximal tubule epithelial cells. PLoS ONE 8:e51842","journal-title":"PLoS ONE"},{"key":"998_CR145","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1158\/1078-0432.CCR-07-4306","volume":"14","author":"HM Verheul","year":"2008","unstructured":"Verheul HM, Salumbides B, Van Erp K, Hammers H, Qian DZ, Sanni T, Atadja P, Pili R (2008) Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors. Clin Cancer Res 14:3589\u20133597","journal-title":"Clin Cancer Res"},{"key":"998_CR146","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbadis.2007.09.005","volume":"1782","author":"DW Walsh","year":"2008","unstructured":"Walsh DW, Roxburgh SA, McGettigan P, Berthier CC, Higgins DG, Kretzler M, Cohen CD, Mezzano S, Brazil DP, Martin F (2008) Co-regulation of Gremlin and Notch signalling in diabetic nephropathy. Biochim Biophys Acta 1782:10\u201321","journal-title":"Biochim Biophys Acta"},{"key":"998_CR147","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1440-1797.2005.00334.x","volume":"10","author":"W Wang","year":"2005","unstructured":"Wang W, Koka V, Lan HY (2005a) Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) 10:48\u201356","journal-title":"Nephrology (Carlton)"},{"key":"998_CR148","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1158\/1078-0432.CCR-04-1092","volume":"11","author":"XF Wang","year":"2005","unstructured":"Wang XF, Qian DZ, Ren M, Kato Y, Wei Y, Zhang L, Fansler Z, Clark D, Nakanishi O, Pili R (2005b) Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma. Clin Cancer Res 11:3535\u20133542","journal-title":"Clin Cancer Res"},{"key":"998_CR149","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1681\/ASN.2006030278","volume":"17","author":"S Wang","year":"2006","unstructured":"Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R (2006) Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17:2504\u20132512","journal-title":"J Am Soc Nephrol"},{"key":"998_CR150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","volume":"1","author":"RN Wang","year":"2014","unstructured":"Wang RN, Green J, Wang Z, Deng Y, Qiao M, Peabody M, Zhang Q, Ye J, Yan Z, Denduluri S, Idowu O, Li M, Shen C, Hu A, Haydon RC, Kang R, Mok J, Lee MJ, Luu HL, Shi LL (2014a) Bone morphogenetic protein (BMP) signaling in development and human diseases. Genes Dis 1:87\u2013105","journal-title":"Genes Dis"},{"key":"998_CR151","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ki.2014.111","volume":"86","author":"X Wang","year":"2014","unstructured":"Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F (2014b) Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy. Kidney Int 86:712\u2013725","journal-title":"Kidney Int"},{"key":"998_CR152","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1002\/jcp.24938","volume":"230","author":"YQ Wang","year":"2015","unstructured":"Wang YQ, Cao Q, Wang F, Huang LY, Sang TT, Liu F, Chen SY (2015) SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation. J Cell Physiol 230:2098\u20132107","journal-title":"J Cell Physiol"},{"key":"998_CR153","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4161\/auto.6788","volume":"4","author":"Y Wei","year":"2008","unstructured":"Wei Y, Sinha S, Levine B (2008) Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4:949\u2013951","journal-title":"Autophagy"},{"key":"998_CR154","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrd2130","volume":"5","author":"S Wilhelm","year":"2006","unstructured":"Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S (2006) Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 5:835\u2013844","journal-title":"Nat Rev Drug Discov"},{"key":"998_CR155","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1080\/15384101.2015.1120916","volume":"14","author":"J Wu","year":"2015","unstructured":"Wu J, Huang YF, Zhou XK, Zhang W, Lian YF, Lv XB, Gao XR, Lin HK, Zeng YX, Huang JQ (2015) Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint. Cell Cycle 14:3877\u20133884","journal-title":"Cell Cycle"},{"key":"998_CR156","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12882-017-0630-6","volume":"18","author":"WP Wu","year":"2017","unstructured":"Wu WP, Tsai YG, Lin TY, Wu MJ, Lin CY (2017) The attenuation of renal fibrosis by histone deacetylase inhibitors is associated with the plasticity of FOXP3\u00a0+\u00a0IL-17\u00a0+\u00a0T cells. BMC Nephrol 18:225","journal-title":"BMC Nephrol"},{"key":"998_CR157","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1242\/dev.049437","volume":"137","author":"S Xia","year":"2010","unstructured":"Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137:1075\u20131084","journal-title":"Development"},{"key":"998_CR158","doi-asserted-by":"crossref","first-page":"7296092","DOI":"10.1155\/2016\/7296092","volume":"2016","author":"S Xu","year":"2016","unstructured":"Xu S, Gao Y, Zhang Q, Wei S, Chen Z, Dai X, Zeng Z, Zhao KS (2016) SIRT1\/3 activation by resveratrol attenuates acute kidney injury in a septic rat model. Oxid Med Cell Longev 2016:7296092","journal-title":"Oxid Med Cell Longev"},{"key":"998_CR159","doi-asserted-by":"crossref","first-page":"F997","DOI":"10.1152\/ajprenal.00186.2017","volume":"313","author":"MK Yanda","year":"2017","unstructured":"Yanda MK, Liu Q, Cebotaru L (2017a) An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease. Am J Physiol Renal Physiol 313:F997\u2013F1004","journal-title":"Am J Physiol Renal Physiol"},{"key":"998_CR160","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.1074\/jbc.M117.803775","volume":"292","author":"MK Yanda","year":"2017","unstructured":"Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L (2017b) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem 292:17897\u201317908","journal-title":"J Biol Chem"},{"key":"998_CR161","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1681\/ASN.2005111187","volume":"18","author":"M Yoshikawa","year":"2007","unstructured":"Yoshikawa M, Hishikawa K, Marumo T, Fujita T (2007) Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. J Am Soc Nephrol 18:58\u201365","journal-title":"J Am Soc Nephrol"},{"key":"998_CR162","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejphar.2010.05.055","volume":"642","author":"M Yoshikawa","year":"2010","unstructured":"Yoshikawa M, Hishikawa K, Idei M, Fujita T (2010) Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. Eur J Pharmacol 642:28\u201336","journal-title":"Eur J Pharmacol"},{"key":"998_CR163","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/01.ASN.0000024253.59665.F1","volume":"13","author":"Z Yu","year":"2002","unstructured":"Yu Z, Zhang W, Kone BC (2002) Histone deacetylases augment cytokine induction of the iNOS gene. J Am Soc Nephrol 13:2009\u20132017","journal-title":"J Am Soc Nephrol"},{"key":"998_CR164","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1046\/j.1523-1755.2003.00162.x","volume":"64","author":"L Yu","year":"2003","unstructured":"Yu L, Border WA, Huang Y, Noble NA (2003) TGF-beta isoforms in renal fibrogenesis. Kidney Int 64:844\u2013856","journal-title":"Kidney Int"},{"key":"998_CR165","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1681\/ASN.2009080805","volume":"21","author":"S Yung","year":"2010","unstructured":"Yung S, Cheung KF, Zhang Q, Chan TM (2010) Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol 21:1912\u20131927","journal-title":"J Am Soc Nephrol"},{"key":"998_CR166","doi-asserted-by":"crossref","first-page":"874","DOI":"10.12688\/f1000research.10445.1","volume":"6","author":"S Yung","year":"2017","unstructured":"Yung S, Yap DY, Chan TM (2017) Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis. F1000Res 6:874","journal-title":"F1000Res"},{"key":"998_CR167","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.2353\/ajpath.2010.100047","volume":"177","author":"T Zhang","year":"2010","unstructured":"Zhang T, Fields JZ, Opdenaker L, Otevrel T, Masuda E, Palazzo JP, Isenberg GA, Goldstein SD, Brand M, Boman BM (2010) Survivin-induced Aurora-B kinase activation: a mechanism by which APC mutations contribute to increased mitoses during colon cancer development. Am J Pathol 177:2816\u20132826","journal-title":"Am J Pathol"},{"key":"998_CR168","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1172\/JCI64401","volume":"123","author":"X Zhou","year":"2013","unstructured":"Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X (2013) Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest 123:3084\u20133098","journal-title":"J Clin Invest"},{"key":"998_CR169","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.cellsig.2013.05.007","volume":"25","author":"S Zhuang","year":"2013","unstructured":"Zhuang S (2013) Regulation of STAT signaling by acetylation. Cell Signal 25:1924\u20131931","journal-title":"Cell Signal"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-017-0998-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-017-0998-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-017-0998-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T13:21:25Z","timestamp":1751116885000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-017-0998-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":172,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["998"],"URL":"https:\/\/doi.org\/10.1007\/s12272-017-0998-7","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}