{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:41:52Z","timestamp":1792543312524,"version":"4.5.0"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI14C2469"],"award-info":[{"award-number":["HI14C2469"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s12272-018-1016-4","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T03:01:12Z","timestamp":1522810872000},"page":"372-383","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":263,"title":["Causes of hyperhomocysteinemia and its pathological significance"],"prefix":"10.1007","volume":"41","author":[{"given":"Jihyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngjoo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"1016_CR1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0735-1097(99)00216-8","volume":"34","author":"P Abhiram","year":"1999","unstructured":"Abhiram P, Neil PA, Feroz AP, Mohsin H, Arshed AQ (1999) Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability. J Am Coll Cardiol 34:507\u2013514","journal-title":"J Am Coll Cardiol"},{"key":"1016_CR2","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/0026-0495(93)90198-W","volume":"42","author":"RH Allen","year":"1993","unstructured":"Allen RH, Stabler SP, Lindenbaum J (1993) Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 42:1448\u20131460","journal-title":"Metabolism"},{"key":"1016_CR3","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1002\/cncr.10343","volume":"94","author":"G Almadori","year":"2002","unstructured":"Almadori G, Bussu F, Galli J, Cadoni G, Zappacosta B, Persichilli S, Minucci A, Giardina B (2002) Serum folate and homocysteine levels in head and neck squamous cell carcinoma. Cancer 94:1006\u20131011","journal-title":"Cancer"},{"key":"1016_CR4","first-page":"601","volume":"48","author":"S Asfar","year":"2007","unstructured":"Asfar S, Safar HA (2007) Homocysteine levels and peripheral arterial occlusive disease: a prospective cohort study and review of the literature. J Cardiovasc Surg (Torino) 48:601\u2013605","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"1016_CR5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/2193-1801-2-423","volume":"2","author":"SA Bamashmoos","year":"2013","unstructured":"Bamashmoos SA, Al-Nuzaily MA, Al-Meeri AM, Ali FH (2013) Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients. SpringerPlus 2:423. https:\/\/doi.org\/10.1186\/2193-1801-2-423","journal-title":"SpringerPlus"},{"key":"1016_CR6","first-page":"248","volume":"12","author":"J Blacher","year":"1999","unstructured":"Blacher J, Demuth K, Guerin AP, Vadez C, Moatti N, Safar ME, London GM (1999) Association between plasma homocysteine concentrations and cardiac hypertrophy in end-stage renal disease. J Nephrol 12:248\u2013255","journal-title":"J Nephrol"},{"key":"1016_CR7","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/nrn1986","volume":"7","author":"HJ Blom","year":"2006","unstructured":"Blom HJ, Shaw GM, den Heijer M, Finnell RH (2006) Neural tube defects and folate: case far from closed. Nat Rev Neurosci 7:724\u2013731","journal-title":"Nat Rev Neurosci"},{"key":"1016_CR8","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","volume":"88","author":"R Brookmeyer","year":"1998","unstructured":"Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer\u2019s disease in the United States and the public health impact of delaying disease onset. Am J Public Health 88:1337\u20131342","journal-title":"Am J Public Health"},{"key":"1016_CR9","first-page":"482","volume":"2006","author":"R Carmel","year":"2006","unstructured":"Carmel R (2006) Cobalamin (vitamin B-12) modern nutrition in health and disease. Cobalamin 2006:482\u2013497","journal-title":"Cobalamin"},{"key":"1016_CR10","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood-2008-03-040253","volume":"112","author":"R Carmel","year":"2008","unstructured":"Carmel R (2008) How i treat cobalamin (vitamin B12) deficiency. Blood 112:2214\u20132221","journal-title":"Blood"},{"key":"1016_CR11","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1089\/thy.1999.9.1163","volume":"9","author":"B Catargi","year":"1999","unstructured":"Catargi B, Parrot-Roulaud F, Cochet C, Ducassou D, Roger P, Tabarin A (1999) Homocysteine, hypothyroidism, and effect of thyroid hormone replacement. Thyroid 9:1163\u20131166","journal-title":"Thyroid"},{"key":"1016_CR12","volume-title":"Biochemistry: Lippincott\u2019s illustrated reviews","author":"PC Champe","year":"2008","unstructured":"Champe PC, Harvey RA (2008) Biochemistry: Lippincott\u2019s illustrated reviews, 4th edn. Lippincott Williams and Wilkins, Philadelphia","edition":"4"},{"key":"1016_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0065-2571(98)00029-6","volume":"39","author":"P Chen","year":"1999","unstructured":"Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, Green R, Kruger WD, Garrow TA, Jacobsen DW (1999) Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease. Adv Enzyme Reg 39:93\u2013109","journal-title":"Adv Enzyme Reg"},{"key":"1016_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1001\/archinternmed.2008.574","volume":"169","author":"WG Christen","year":"2009","unstructured":"Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE (2009) Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the women\u2019s antioxidant and folic acid cardiovascular study. Arch Intern Med 169:335\u2013341","journal-title":"Arch Intern Med"},{"key":"1016_CR15","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1096\/fj.06-7435com","volume":"21","author":"G Chwatko","year":"2007","unstructured":"Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H (2007) Mutations in methylenetetrahydrofolate reductase or cystathionine \u03b2-syntase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J 21:1707\u20131713","journal-title":"FASEB J"},{"key":"1016_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0811-y","author":"F Cicone","year":"2017","unstructured":"Cicone F, Santaguida MG, My G, Mancuso G, Papa A, Persechino R, Virili C, Brusca N, Tofani A, Scopinaro F, Centanni M (2017) Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-017-0811-y","journal-title":"J Endocrinol Invest"},{"key":"1016_CR17","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","volume":"55","author":"R Clarke","year":"1998","unstructured":"Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM (1998) Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer\u2019s disease. Arch Neurol 55:1449\u20131455","journal-title":"Arch Neurol"},{"key":"1016_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10545-005-0243-2","volume":"29","author":"PT Clayton","year":"2006","unstructured":"Clayton PT (2006) B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis 29:317\u2013326","journal-title":"J Inherit Metab Dis"},{"key":"1016_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0735-1097(00)00756-7","volume":"36","author":"GE Cooke","year":"2000","unstructured":"Cooke GE, Eaton GM, Whitby G, Kennedy RA, Binkley PF, Moeschberger ML, Leier CV (2000) Plasma atherogenic markers in congestive heart failure and post transplant (heart) patients. J Am Coll Cardiol 36:509\u2013516","journal-title":"J Am Coll Cardiol"},{"key":"1016_CR20","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/S0959-8049(97)00121-4","volume":"33","author":"G Corona","year":"1997","unstructured":"Corona G, Toffoli G, Fabris M, Viel A, Zarrelli A, Donada C, Boiocchi M (1997) Homocysteine accumulation in human ovarian carcinoma ascitic\/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells. Eur J Cancer 33:1284\u20131290","journal-title":"Eur J Cancer"},{"key":"1016_CR21","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2165\/00003495-200262040-00005","volume":"62","author":"C Desouza","year":"2002","unstructured":"Desouza C, Keebler M, McNamara DB, Fonseca V (2002) Drugs affecting homocysteine metabolism: impact on cardiovascular risk. Drugs 62:605\u2013616","journal-title":"Drugs"},{"key":"1016_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1042\/BJ20061868","volume":"405","author":"T Dikran","year":"2007","unstructured":"Dikran T, Rajindar SS (2007) Age-associated perturbations in glutathione synthesis in mouse liver. Biochem J 405:583\u2013589","journal-title":"Biochem J"},{"key":"1016_CR23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/ndt\/17.5.865","volume":"17","author":"D Ducloux","year":"2002","unstructured":"Ducloux D, Aboubakr A, Motte G, Toubin G, Fournier V, Chalopin JM, Dr\u00fceke T, Massy ZA (2002) Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and B12. Nephrol Dial Transplant 17:865\u2013870","journal-title":"Nephrol Dial Transplant"},{"key":"1016_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1744-9081-1-25","volume":"1","author":"S Dutta","year":"2005","unstructured":"Dutta S, Sinha S, Chattopadhyay A, Gangopadhyay PK, Mukhopadhyay J, Singh M, Mukhopadhyay K (2005) Cystathionine \u03b2-synthase T833C\/844INS68 polymorphism: a family-based study on mentally retarded children. Behav Brain Funct 1:25. https:\/\/doi.org\/10.1186\/1744-9081-1-25","journal-title":"Behav Brain Funct"},{"key":"1016_CR25","doi-asserted-by":"publisher","first-page":"e55483","DOI":"10.1371\/journal.pone.0055483","volume":"8","author":"R Esse","year":"2013","unstructured":"Esse R, Rocha MS, Barroso M, Florindo C, Teerlink T, Kok RM, Smulders YM, Rivera I, Leandro P, Koolwijk P, Castro R, Blom HJ, de Almeida IT (2013) Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells. PLoS ONE 8:e55483","journal-title":"PLoS ONE"},{"issue":"10","key":"1016_CR26","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1002\/lary.26514","volume":"127","author":"T Fasano","year":"2017","unstructured":"Fasano T, Pertinhez TA, Tribi L, Lasagni D, Pilia A, Vecchia L, Baricchi R, Bianchin G (2017) Laboratory assessment of sudden sensorineural hearing loss: a case-control study. Laryngoscope 127(10):2375\u20132381","journal-title":"Laryngoscope"},{"issue":"9","key":"1016_CR27","first-page":"1137","volume":"61","author":"P Fournier","year":"2015","unstructured":"Fournier P, Fourcade J, Roncalli J, Salvayre R, Galinier M, Causs\u00e9 E (2015) Homocysteine in chronic heart failure. Clin Lab 61(9):1137\u20131145","journal-title":"Clin Lab"},{"key":"1016_CR28","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1024\/0040-5930.62.9.641","volume":"62","author":"B Fowler","year":"2005","unstructured":"Fowler B (2005) Homocysteine\u2014an independent risk factor for cardiovascular and thrombotic diseases. Ther Umsch 62:641\u2013646","journal-title":"Ther Umsch"},{"key":"1016_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Alam SF (2015) Role of homocysteine in the development of cardiovascular disease. Nutr J. https:\/\/doi.org\/10.1186\/1475-2891-14-6","journal-title":"Nutr J"},{"key":"1016_CR30","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1046\/j.1523-1755.2002.00666.x","volume":"62","author":"H Ghandour","year":"2002","unstructured":"Ghandour H, Bagley PJ, Shemin D, Hsu N, Jacques PF, Dworkin L, Bostom AG, Selhub J (2002) Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of l-folinic or folic acid. Kidney Int 62:2246\u20132249","journal-title":"Kidney Int"},{"key":"1016_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3126\/nepjoph.v5i2.8728","volume":"5","author":"S Ghosh","year":"2013","unstructured":"Ghosh S, Saha M, Das D (2013) A study on plasma homocysteine level in age-related macular degeneration. Nepal J Ophthalmol 5:195\u2013200. https:\/\/doi.org\/10.3126\/nepjoph.v5i2.8728","journal-title":"Nepal J Ophthalmol"},{"key":"1016_CR32","first-page":"340","volume":"5","author":"C Goccer","year":"2009","unstructured":"Goccer C, Genc U, Eryilmaz A, Islam A, Boynuegri S, Bakir F (2009) Homocysteine, folate and vitamin B12 concentrations in middle aged adults presenting with sensorineural hearing impairment. Int Adv Otol 5:340\u2013344","journal-title":"Int Adv Otol"},{"key":"1016_CR33","unstructured":"Healthline (2016) What is megaloblastic anemia? http:\/\/www.healthline.com\/health\/megaloblastic-anemia . Accessed 20 Oct 2016"},{"key":"1016_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10545-010-9177-4","volume":"34","author":"JB Henk","year":"2011","unstructured":"Henk JB, Yvo S (2011) Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis 34:75\u201381","journal-title":"J Inherit Metab Dis"},{"key":"1016_CR35","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","volume":"316","author":"Homocysteine Lowering Trialists\u2019 Collaboration","year":"1998","unstructured":"Homocysteine Lowering Trialists\u2019 Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 316:894\u2013898","journal-title":"BMJ"},{"issue":"10","key":"1016_CR36","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s12603-017-0989-x","volume":"21","author":"C Hooper","year":"2017","unstructured":"Hooper C, De Souto Barreto P, Coley N, Causs\u00e9 E, Payoux P, Salabert AS, Cesari M, Andrieu S, Bowman GL, Weiner M, Vellas B (2017) Cross-sectional associations of total plasma homocysteine with cortical \u03b2-amyloid independently and as a function of omega 3 polyunsaturated fatty acid status in older adults at risk of dementia. J Nutr Health Aging. 21(10):1075\u20131080","journal-title":"J Nutr Health Aging."},{"key":"1016_CR37","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/ajcn\/69.3.564","volume":"69","author":"DK Houston","year":"1999","unstructured":"Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT (1999) Age-related hearing loss, vitamin B12, and folate in elderly women. Am J Clin Nutr 69:564\u2013571","journal-title":"Am J Clin Nutr"},{"key":"1016_CR38","doi-asserted-by":"publisher","first-page":"10585","DOI":"10.1038\/srep10585","volume":"5","author":"P Huang","year":"2015","unstructured":"Huang P, Wang F, Sah BK, Jiang J, Ni Z, Wang J, Sun X (2015) Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis. Sci Rep 5:10585. https:\/\/doi.org\/10.1038\/srep10585","journal-title":"Sci Rep"},{"key":"1016_CR39","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.4065\/83.11.1203","volume":"83","author":"LL Humphrey","year":"2008","unstructured":"Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M (2008) Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin Proc 83:1203\u20131212","journal-title":"Mayo Clin Proc"},{"issue":"8","key":"1016_CR40","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.1016\/j.cardfail.2012.06.521","volume":"18","author":"NS Iqbal","year":"2012","unstructured":"Iqbal NS, Wu Y, Hazen S, Tang WHW (2012) Elevated plasma homocysteine identifies patients with chronic heart failure at increased cardiovascular risk. J Card Fail. 18(8):S87","journal-title":"J Card Fail."},{"key":"1016_CR41","first-page":"24","volume":"445","author":"T Iroku-Malize","year":"2016","unstructured":"Iroku-Malize T, Kirsch S (2016) Eye conditions in older adults: age-related macular degeneration. FP Essent 445:24\u201328","journal-title":"FP Essent"},{"key":"1016_CR42","doi-asserted-by":"crossref","first-page":"623","DOI":"10.33549\/physiolres.931566","volume":"58","author":"K Karolczak","year":"2009","unstructured":"Karolczak K, Olas B (2009) Mechanism of action of homocysteine and its thiolactone in hemostasis system. Physiol Res 58:623\u2013633","journal-title":"Physiol Res"},{"key":"1016_CR43","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1038\/sj.bjc.6690305","volume":"79","author":"I Kato","year":"1999","unstructured":"Kato I, Dnistrian AM, Schwartz M, Toniolo P, Koenig K, Shore RE, Akhmedkhanov A, Zeleniuch-Jacquotte A, Riboli E (1999) Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. Br J Cancer 79:1917\u20131921","journal-title":"Br J Cancer"},{"issue":"4","key":"1016_CR44","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.3748\/wjg.v21.i4.1081","volume":"1","author":"AH Keshteli","year":"2015","unstructured":"Keshteli AH, Baracos VE, Madsen KL (2015) Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases. World J Gastroenterol 1(4):1081\u20131090. https:\/\/doi.org\/10.3748\/wjg.v21.i4.1081","journal-title":"World J Gastroenterol"},{"key":"1016_CR45","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.biochi.2012.11.004","volume":"95","author":"R Kozyraki","year":"2013","unstructured":"Kozyraki R, Cases O (2013) Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders. Biochimie 95:1002\u20131007","journal-title":"Biochimie"},{"key":"1016_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1006\/mgme.2000.2993","volume":"70","author":"WD Kruger","year":"2000","unstructured":"Kruger WD, Evans AA, Wang L, Malinow MR, Duell PB, Anderson PH, Block PC, Hess DL, Graf EE, Upson B (2000) Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol Genet Metab 70:53\u201360","journal-title":"Mol Genet Metab"},{"issue":"1\u20132","key":"1016_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.heares.2011.12.006","volume":"284","author":"S Kundu","year":"2012","unstructured":"Kundu S, Munjal C, Tyagi N, Sen U, Tyagi AC, Tyagi SC (2012) Folic acid improves inner ear vascularization in hyperhomocysteinemic mice. Hear Res 284(1\u20132):42\u201351","journal-title":"Hear Res"},{"key":"1016_CR48","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S0272-6386(12)80371-4","volume":"23","author":"SA Laidlaw","year":"1994","unstructured":"Laidlaw SA, Berg RL, Kopple JD, Naito H, Walker WG, Walser M (1994) Patterns of fasting plasma amino acid levels in chronic renal insufficiency: results from the feasibility phase of the modification of diet in renal disease study. Am J Kidney Dis 23:504\u2013513","journal-title":"Am J Kidney Dis"},{"key":"1016_CR49","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1073\/pnas.95.6.3059","volume":"95","author":"D Leclerc","year":"1998","unstructured":"Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA (1998) Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci USA 95:3059\u20133064","journal-title":"Proc Natl Acad Sci USA"},{"key":"1016_CR50","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1182\/blood-2002-03-0727","volume":"100","author":"SR Lentz","year":"2002","unstructured":"Lentz SR, Piegors DJ, Fern\u00e1ndez JA, Erger RA, Arning E, Malinow MR, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD (2002) Effect of hyperhomocysteinemia on protein C activation and activity. Blood 100:2108\u20132112","journal-title":"Blood"},{"key":"1016_CR51","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1093\/hmg\/5.12.1851","volume":"5","author":"YN Li","year":"1996","unstructured":"Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD (1996) Cloning, mapping and RNA analysis of the human methionine synthase gene. Hum Mol Genet 5:1851\u20131858","journal-title":"Hum Mol Genet"},{"key":"1016_CR52","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1093\/ndt\/13.3.656","volume":"13","author":"FMT Loehrer","year":"1998","unstructured":"Loehrer FMT, Angst CP, Brunner FP, Haefeli WE, Fowler B (1998) Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions? Nephrol Dial Transplant 13:656\u2013661","journal-title":"Nephrol Dial Transplant"},{"key":"1016_CR53","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/01.HJ.0000416274.98729.66","volume":"65","author":"PD Loprinzi","year":"2012","unstructured":"Loprinzi PD, Brown K, Gilham B (2012) Breaking news: high homocysteine levels may increase hearing loss. Hear J 65:30\u201332. https:\/\/doi.org\/10.1097\/01.HJ.0000416274.98729.66","journal-title":"Hear J"},{"key":"1016_CR54","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1172\/JCI118776","volume":"98","author":"J Loscalzo","year":"1996","unstructured":"Loscalzo J (1996) The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 98:5\u20137","journal-title":"J Clin Invest"},{"key":"1016_CR55","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/07315724.2000.10718958","volume":"19","author":"EA Lowenthal","year":"2000","unstructured":"Lowenthal EA, Mayo MS, Cornwell PE, Thornley-Brown D (2000) Homocysteine elevation in sickle cell disease. J Am Coll Nutr 19:608\u2013612","journal-title":"J Am Coll Nutr"},{"key":"1016_CR56","first-page":"421","volume":"123","author":"MR Malinow","year":"1994","unstructured":"Malinow MR, Axthelm MK, Meredith MJ, MacDonald NA, Upson BM (1994) Upson Synthesis and transsulfuration of homocysteine in blood. J Lab Clin Med 123:421\u2013429","journal-title":"J Lab Clin Med"},{"key":"1016_CR57","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev.med.60.041807.123308","volume":"60","author":"BA Maron","year":"2009","unstructured":"Maron BA, Loscalzo J (2009) The treatment of hyperhomocysteinemia. Annu Rev Med 60:39\u201354","journal-title":"Annu Rev Med"},{"key":"1016_CR58","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1096\/fj.14-259283","volume":"29","author":"R Mart\u00ednez-Vega","year":"2015","unstructured":"Mart\u00ednez-Vega R, Garrido F, Partearroyo T, Cediel R, Zeisel SH, Mart\u00ednez-\u00c1lvarez C, Varela-Moreiras G, Varela-Nieto I, Pajares MA (2015) Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB J 29:418\u2013432. https:\/\/doi.org\/10.1096\/fj.14-259283","journal-title":"FASEB J"},{"key":"1016_CR59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8","volume":"13","author":"A McCaddon","year":"1998","unstructured":"McCaddon A, Davies G, Hudson P, Tandy S, Cattell H (1998) Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 13:235\u2013239","journal-title":"Int J Geriatr Psychiatry"},{"key":"1016_CR60","first-page":"7","volume":"8","author":"AL Miller","year":"2003","unstructured":"Miller AL (2003) The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev 8:7\u201319","journal-title":"Altern Med Rev"},{"key":"1016_CR61","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/ajcn\/59.5.1033","volume":"59","author":"JW Miller","year":"1994","unstructured":"Miller JW, Nadeau MR, Smith D, Selhub J (1994) Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr 59:1033\u20131039","journal-title":"Am J Clin Nutr"},{"key":"1016_CR62","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0895-7061(01)02286-5","volume":"15","author":"A Miller","year":"2002","unstructured":"Miller A, Mujumdar V, Palmer L, Bower JD, Tyagi SC (2002) Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensiverats. Am J Hypertens 15:157\u2013163","journal-title":"Am J Hypertens"},{"key":"1016_CR63","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3945\/ajcn.112.049932","volume":"97","author":"JW Miller","year":"2013","unstructured":"Miller JW, Beresford SAA, Neuhouser ML, Cheng TYD, Song A, Brown EC, Zheng Y, Rodriguez B, Green R, Ulrich CM (2013) Homocysteine, cysteine, and risk of incident colorectal cancer in women\u2019s health initiative observational cohort. Am J Clin Nutr 97:827\u2013834","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"1016_CR64","doi-asserted-by":"publisher","first-page":"11952","DOI":"10.1038\/s41598-017-09731-y","volume":"7","author":"R Mohamed","year":"2017","unstructured":"Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A (2017) Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress. Sci Rep 7(1):11952","journal-title":"Sci Rep"},{"key":"1016_CR65","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0021-9150(00)00537-2","volume":"155","author":"MS Morris","year":"2001","unstructured":"Morris MS, Bostom AG, Jacques PF, Selhub J, Rosenberg IH (2001) Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US national health and nutrition examination survey. Atherosclerosis 155:195\u2013200","journal-title":"Atherosclerosis"},{"key":"1016_CR66","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0021-9258(19)77322-0","volume":"231","author":"SH Mudd","year":"1958","unstructured":"Mudd SH, Cantoni GL (1958) Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers\u2019 yeast. J Biol Chem 231:481\u2013492","journal-title":"J Biol Chem"},{"key":"1016_CR67","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1053\/ajkd.2002.36320","volume":"40","author":"T Nakanishi","year":"2002","unstructured":"Nakanishi T, Otaki Y, Hasuike Y, Nanami M, Itahana R, Miyagawa K, Nishikage H, Izumi M, Takamitsu Y (2002) Association of hyperhomocysteinemia with plasma sulfate and urine sulfate excretion in patients with progressive renal disease. Am J Kidney Dis 40:909\u2013915","journal-title":"Am J Kidney Dis"},{"key":"1016_CR68","unstructured":"Natural Kidney Association (2015) Glomerular filtration rate (GFR). https:\/\/www.kidney.org\/atoz\/content\/gfr . Accessed 20 Oct 2016"},{"key":"1016_CR69","first-page":"698","volume":"11","author":"V Norouzi","year":"2011","unstructured":"Norouzi V, Seifi M, Fallah S, Korani M, Samadikuchaksaraei A (2011) Effect of oral contraceptive therapy on homocysteine and C-reactive protein levels in women: an observational study. Anadolu Kardiyol Derg 11:698\u2013702","journal-title":"Anadolu Kardiyol Derg"},{"key":"1016_CR70","first-page":"443","volume":"60","author":"A Orzechowska-Pawilojc","year":"2009","unstructured":"Orzechowska-Pawilojc A, Siekierska-Hellmann M, Syrenicz A, Sworczak K (2009) Homocysteine, folate, and cobalamin levels in hyperthyroid women before and after treatment. Endokrynol Pol 60:443\u2013448","journal-title":"Endokrynol Pol"},{"key":"1016_CR71","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1007\/s00018-006-6249-6","volume":"63","author":"MA Pajares","year":"2006","unstructured":"Pajares MA, P\u00e9rez-Sala D (2006) Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? Cell Mol Life Sci 63:2792\u20132803","journal-title":"Cell Mol Life Sci"},{"key":"1016_CR72","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2165\/11532990-000000000-00000","volume":"49","author":"K Pietrzik","year":"2010","unstructured":"Pietrzik K, Bailey L, Shane B (2010) Folic acid and l-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 49:535\u2013548","journal-title":"Clin Pharmacokinet"},{"key":"1016_CR73","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13343","author":"A Pinna","year":"2016","unstructured":"Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G (2016) Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis. Acta Ophthalmol. https:\/\/doi.org\/10.1111\/aos.13343","journal-title":"Acta Ophthalmol"},{"key":"1016_CR74","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2478\/v10019-010-0022-z","volume":"44","author":"N Plazar","year":"2010","unstructured":"Plazar N, Jurdana M (2010) Hyperhomocysteinemia and the role of B vitamins in cancer. Radiol Oncol 44:79\u201385. https:\/\/doi.org\/10.2478\/v10019-010-0022-z","journal-title":"Radiol Oncol"},{"key":"1016_CR75","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1475-2891-11-2","volume":"11","author":"X Qin","year":"2012","unstructured":"Qin X, Li J, Cui Y, Liu Z, Zhao Z, Ge J, Guan D, Hu J, Wang Y, Zhang F, Xu X, Wang X, Xu X, Huo Y (2012) MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults. Nutr J 11:2. https:\/\/doi.org\/10.1186\/1475-2891-11-2","journal-title":"Nutr J"},{"key":"1016_CR76","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/bbrc.1998.9079","volume":"254","author":"I Qu\u00e9r\u00e9","year":"1999","unstructured":"Qu\u00e9r\u00e9 I, Paul V, Rouillac C, Janbon C, London J, Demaille J, Kamoun P, Dufier JL, Abitbol M, Chass\u00e9 JF (1999) Spatial and temporal expression of the cystathionine beta-synthase gene during early human development. Biochem Biophys Res Commun 254:127\u2013137","journal-title":"Biochem Biophys Res Commun"},{"key":"1016_CR77","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0009-9120(01)00187-4","volume":"34","author":"D Qujeq","year":"2001","unstructured":"Qujeq D, Omran TS, Hosini L (2001) Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction. Clin Biochem 34:97\u2013101","journal-title":"Clin Biochem"},{"key":"1016_CR78","first-page":"147","volume":"8","author":"M Qureshi","year":"2003","unstructured":"Qureshi M, Zhang X, Ul-Haq I, Xiang J, Prasad K (2003) Serum levels of homocysteine in mice with malignant tumours. Exp Clin Cardiol 8:147\u2013149","journal-title":"Exp Clin Cardiol"},{"key":"1016_CR79","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/clinchem\/31.4.624","volume":"31","author":"H Refsum","year":"1985","unstructured":"Refsum H, Helland S, Ueland PM (1985) Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 31:624\u2013628","journal-title":"Clin Chem"},{"key":"1016_CR80","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ajo.2006.08.032","volume":"143","author":"E Rochtchina","year":"2007","unstructured":"Rochtchina E, Wang JJ, Flood VM, Mitchell P (2007) Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the blue mountains eye study. Am J Ophthalmol 143:344\u2013346","journal-title":"Am J Ophthalmol"},{"key":"1016_CR81","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12098-008-0051-4","volume":"75","author":"MN Sadananda Adiga","year":"2008","unstructured":"Sadananda Adiga MN, Chandy S, Ramaswamy G, Appaji L, Krishnamoorthy L (2008) Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia. Indian J Pediatr 75:235\u2013238","journal-title":"Indian J Pediatr"},{"key":"1016_CR82","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","volume":"19","author":"J Selhub","year":"1999","unstructured":"Selhub J (1999) Homocysteine metabolism. Annurev Nutr 19:217\u2013246","journal-title":"Annurev Nutr"},{"key":"1016_CR83","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMoa011613","volume":"346","author":"S Seshadri","year":"2002","unstructured":"Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D\u2019Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease. N Engl J Med 346:476\u2013483","journal-title":"N Engl J Med"},{"issue":"16","key":"1016_CR84","first-page":"30200","volume":"S1871\u20134021","author":"B Sreckovic","year":"2016","unstructured":"Sreckovic B, Sreckovic VD, Soldatovic I, Colak E, Sumarac-Dumanovic M, Janeski H, Janeski N, Gacic J, Mrdovic I (2016) Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes Metab Syndr S1871\u20134021(16):30200\u201330204","journal-title":"Diabetes Metab Syndr"},{"key":"1016_CR85","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0010-7824(92)90047-W","volume":"45","author":"RP Steegers-Theunissen","year":"1992","unstructured":"Steegers-Theunissen RP, Boers GH, Steegers EA, Trijbels FJ, Thomas CM, Eskes TK (1992) Effects of sub-50 oral contraceptives on homocysteine metabolism: a preliminary study. Contraception 45:129\u2013139","journal-title":"Contraception"},{"key":"1016_CR86","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1093\/ndt\/12.11.2332","volume":"12","author":"ME Suliman","year":"1997","unstructured":"Suliman ME, Anderstam B, Lindholm B, Bergstrom J (1997) Total, free, and protein-bound sulphur amino acids in uraemic patients. Nephrol Dial Transplant 12:2332\u20132338","journal-title":"Nephrol Dial Transplant"},{"key":"1016_CR87","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0009-8981(02)00092-X","volume":"321","author":"CF Sun","year":"2002","unstructured":"Sun CF, Haven TR, Wu TL, Tsao KC, Wu JT (2002) Serum total homocysteine increases with the rapid proliferation rate of tumor cells and decline upon cell death: a potential new tumor marker. Clin Chim Acta 321:55\u201362","journal-title":"Clin Chim Acta"},{"key":"1016_CR88","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/ndt\/gfl044","volume":"21","author":"C Guldener van","year":"2006","unstructured":"van Guldener C (2006) Why is homocysteine elevated in renal failure and what can be expected from homocysteine-lowering? Nephrol Dial Transpl 21:1161\u20131166","journal-title":"Nephrol Dial Transpl"},{"key":"1016_CR89","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-2000-8407","volume":"26","author":"C Guldener van","year":"2000","unstructured":"van Guldener C, Robinson K (2000) Homocysteine and renal disease. Semin Thromb Hemost 26:313\u2013324","journal-title":"Semin Thromb Hemost"},{"key":"1016_CR90","doi-asserted-by":"publisher","first-page":"S234","DOI":"10.1046\/j.1523-1755.2001.59780234.x","volume":"78","author":"C Guldener van","year":"2001","unstructured":"van Guldener C, Stam F, Stehouwer CD (2001) Homocysteine metabolism in renal failure. Kidney Int Suppl 78:S234\u2013S237","journal-title":"Kidney Int Suppl"},{"key":"1016_CR91","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1464-5491.2005.01415.x","volume":"22","author":"BA Veldman","year":"2005","unstructured":"Veldman BA, Vervoort G, Blom H, Smits P (2005) Reduced plasma total homocysteine concentrations in Type 1 diabetes mellitus is determined by increased renal clearance. Diabet Med 22:301\u2013305","journal-title":"Diabet Med"},{"key":"1016_CR92","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1179\/135100003125001260","volume":"8","author":"V Vitvitsky","year":"2003","unstructured":"Vitvitsky V, Mosharov E, Tritt M, Ataullakhanov F, Banerjee R (2003) Redox regulation of homocysteine-dependent glutathione synthesis. Redox Rep 8:57\u201363","journal-title":"Redox Rep"},{"key":"1016_CR93","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/157489009787259991","volume":"4","author":"E Vizzardi","year":"2009","unstructured":"Vizzardi E, Bonadei I, Zanini G, Frattini S, Fiorina C, Raddino R, Dei Cas L (2009) Homocysteine and heart failure: an overview. Recent Pat Cardiovasc Drug Discov 4:15\u201321","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"issue":"6","key":"1016_CR94","doi-asserted-by":"publisher","first-page":"175909141774229","DOI":"10.1177\/1759091417742296","volume":"9","author":"EM Weekman","year":"2017","unstructured":"Weekman EM, Woolums AE, Sudduth TL, Wilcock DM (2017) Hyperhomocysteinemia-induced gene expression changes in the cell types of the brain. ASN Neuro 9(6):1759091417742296","journal-title":"ASN Neuro"},{"key":"1016_CR95","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3132\/dvdr.2007.033","volume":"4","author":"AS Wierzbicki","year":"2007","unstructured":"Wierzbicki AS (2007) Homocysteine and cardiovascular disease: a review of the evidence. Diab Vasc Dis Res 4:143\u2013150","journal-title":"Diab Vasc Dis Res"},{"issue":"1\u20132","key":"1016_CR96","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0009-8981(02)00174-2","volume":"322","author":"LL Wu","year":"2002","unstructured":"Wu LL, Wu JT (2002) Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 322(1\u20132):21\u201328","journal-title":"Clin Chim Acta"},{"issue":"1","key":"1016_CR97","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1897-4287-12-2","volume":"12","author":"X Wu","year":"2014","unstructured":"Wu X, Zou T, Cao N, Ni J, Xu W, Zhou T, Wang X (2014) Plasma homocysteine levels and genetic polymorphisms in folate metabolism are associated with breast cancer risk in Chinese women. Hered Cancer Clin Pract. 12(1):2. https:\/\/doi.org\/10.1186\/1897-4287-12-2","journal-title":"Hered Cancer Clin Pract."},{"key":"1016_CR98","first-page":"923","volume":"26","author":"M Yakub","year":"2010","unstructured":"Yakub M, Iqbal MP, Kakepoto GN, Rafique G, Memon Y, Azam I, Mehboobali N, Parveen S, Haider G (2010) High prevalence of mild hyperhomocysteinemia and folate, B12 and B6 deficiencies in an urban population in Karachi, Pakistan. Pak J Med Sci 26:923\u2013926","journal-title":"Pak J Med Sci"},{"key":"1016_CR99","doi-asserted-by":"publisher","first-page":"e33222","DOI":"10.1371\/journal.pone.0033222","volume":"7","author":"M Yakub","year":"2012","unstructured":"Yakub M, Moti N, Parveen S, Chaudhry B, Azam I, Iqbal MP (2012) Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population. PLoS ONE 7:e33222","journal-title":"PLoS ONE"},{"key":"1016_CR100","doi-asserted-by":"publisher","first-page":"e0123423","DOI":"10.1371\/journal.pone.0123423","volume":"10","author":"D Zhang","year":"2015","unstructured":"Zhang D, Wen X (2015) Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals. PLoS ONE 10:e0123423","journal-title":"PLoS ONE"},{"key":"1016_CR101","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.yjmcc.2012.07.010","volume":"53","author":"D Zhang","year":"2012","unstructured":"Zhang D, Chen Y, Xie X, Liu J, Wang Q, Kong W, Zhu Y (2012) Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol 53:487\u2013496","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"1016_CR102","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.012","volume":"26","author":"J Zhao","year":"2017","unstructured":"Zhao J, Chen H, Liu N, Chen J, Gu Y, Chen J, Yang K (2017) Role of hyperhomocysteinemia and hyperuricemia in pathogenesis of atherosclerosis. J Stroke Cerebroval Dis 26(12):2695\u20132699","journal-title":"J Stroke Cerebroval Dis"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-018-1016-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-018-1016-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-018-1016-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T23:38:11Z","timestamp":1660779491000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-018-1016-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":102,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1016"],"URL":"https:\/\/doi.org\/10.1007\/s12272-018-1016-4","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]},"assertion":[{"value":"23 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}