{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:12:01Z","timestamp":1774602721649,"version":"3.50.1"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2018R1A6A1A03023718"],"award-info":[{"award-number":["NRF-2018R1A6A1A03023718"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2018M3C7A1021858"],"award-info":[{"award-number":["NRF-2018M3C7A1021858"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07048857"],"award-info":[{"award-number":["NRF-2018R1D1A1B07048857"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002573","name":"Yonsei University","doi-asserted-by":"publisher","award":["2018-22-0022"],"award-info":[{"award-number":["2018-22-0022"]}],"id":[{"id":"10.13039\/501100002573","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.1007\/s12272-019-01168-3","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T09:02:35Z","timestamp":1560243755000},"page":"647-657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preventive approach for overcoming dementia"],"prefix":"10.1007","volume":"42","author":[{"given":"HeeYang","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaWon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woogyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-5652","authenticated-orcid":false,"given":"Hye Yun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-7082","authenticated-orcid":false,"given":"YoungSoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"1168_CR1","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1523\/JNEUROSCI.0496-05.2005","volume":"25","author":"PA Adlard","year":"2005","unstructured":"Adlard PA, Perreau VM, Pop V, Cotman CW (2005) Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer\u2019s disease. J Neurosci 25:4217\u20134221","journal-title":"J Neurosci"},{"key":"1168_CR2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1001\/jama.300.15.1774","volume":"300","author":"PS Aisen","year":"2008","unstructured":"Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, Thal LJ (2008) High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300:1774\u20131783","journal-title":"JAMA"},{"key":"1168_CR3","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1212\/WNL.0b013e3181b7849b","volume":"73","author":"TN Akbaraly","year":"2009","unstructured":"Akbaraly TN, Portet F, Fustinoni S, Dartigues J-F, Artero S, Rouaud O, Touchon J, Ritchie K, Berr C (2009) Leisure activities and the risk of dementia in the elderly: results from the three-city study. Neurology 73:854\u2013861","journal-title":"Neurology"},{"key":"1168_CR4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3945\/ajcn.2009.27580","volume":"90","author":"E Albanese","year":"2009","unstructured":"Albanese E, Dangour AD, Uauy R, Acosta D, Guerra M, Guerra SS, Huang Y, Jacob KS, de Rodriguez JL, Noriega LH, Salas A, Sosa AL, Sousa RM, Williams J, Ferri CP, Prince MJ (2009) Dietary fish and meat intake and dementia in Latin America, China, and India: a 10\/66 Dementia Research Group population-based study. Am J Clin Nutr 90:392\u2013400","journal-title":"Am J Clin Nutr"},{"key":"1168_CR5","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1046\/j.1532-5415.2003.51373.x","volume":"51","author":"GS Alexopoulos","year":"2003","unstructured":"Alexopoulos GS (2003) Vascular disease, depression, and dementia. J Am Geriatr Soc 51:1178\u20131180","journal-title":"J Am Geriatr Soc"},{"key":"1168_CR6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1474-4422(17)30040-6","volume":"16","author":"S Andrieu","year":"2017","unstructured":"Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi M-N, Dantoine T, Dartigues J-F, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere J-P, Weiner M, Carri\u00e9 I, Ousset P-J, Vellas B, Vellas B, Guyonnet S, Carri\u00e9 I, Brigitte L, Faisant C, Lala F, Delrieu J, Villars H, Combrouze E, Badufle C, Zueras A, Andrieu S, Cantet C, Morin C, Van Kan GA, Dupuy C, Rolland Y, Caillaud C, Ousset P-J, Foug\u00e8re B, Willis S, Belleville S, Gilbert B, Fontaine F, Dartigues J-F, Marcet I, Delva F, Foubert A, Cerda S, No\u00eblle-Cuffi M, Costes C, Rouaud O, Manckoundia P, Quipourt V, Marilier S, Franon E, Bories L, Pader M-L, Basset M-F, Lapoujade B, Faure V, Li M, Tong Y, Malick-Loiseau C, Cazaban-Campistron E, Desclaux F, Blatge C, Dantoine T, Laubarie-Mouret C, Saulnier I, Cl\u00e9ment J-P, Picat M-A, Bernard-Bourzeix L, Willebois S, D\u00e9sormais I, Cardinaud N, Bonnefoy M, Livet P, Rebaudet P, G\u00e9d\u00e9on C, Burdet C, Terracol F, Pesce A, Roth S, Chaillou S, Louchart S, Sudres K, Lebrun N, Barro-Belaygues N, Touchon J, Bennys K, Gabelle A, Romano A, Touati L, Marelli C, Pays C, Robert P, Le Duff F, Gervais C, Gonfrier S, Gasnier Y, Bordes S, Begorre D, Carpuat C, Khales K, Lefebvre J-F, El Idrissi SM, Skolil P, Salles J-P, Dufouil C, Leh\u00e9ricy S, Chupin M, Mangin J-F, Bouhayia A, Allard M, Ricolfi F, Dubois D, Paule M, Martel B, Cotton F, Bonaf\u00e9 A, Chanalet S, Hugon F, Bonneville F, Cognard C, Chollet F, Payoux P, Voisin T, Peiffer S, Hitzel A, Allard M, Zanca M, Monteil J, Darcourt J, Molinier L, Derumeaux H, Costa N, Vincent C, Perret B, Vinel C, Olivier-Abbal P (2017) Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol 16:377\u2013389","journal-title":"Lancet Neurol"},{"key":"1168_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3988\/jcn.2014.10.4.281","volume":"10","author":"R Ansari","year":"2014","unstructured":"Ansari R, Mahta A, Mallack E, Luo JJ (2014) Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol 10:281\u2013288","journal-title":"J Clin Neurol"},{"key":"1168_CR8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","volume":"367","author":"RJ Bateman","year":"2012","unstructured":"Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC (2012) Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease. N Engl J Med 367:795\u2013804","journal-title":"N Engl J Med"},{"key":"1168_CR9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s004410050955","volume":"290","author":"C Behl","year":"1997","unstructured":"Behl C (1997) Amyloid beta-protein toxicity and oxidative stress in Alzheimer\u2019s disease. Cell Tissue Res 290:471\u2013480","journal-title":"Cell Tissue Res"},{"key":"1168_CR10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(06)70417-3","volume":"5","author":"DA Bennett","year":"2006","unstructured":"Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006) The effect of social networks on the relation between Alzheimer\u2019s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 5:406\u2013412","journal-title":"Lancet Neurol"},{"key":"1168_CR11","first-page":"CD001190","volume":"25","author":"JS Birks","year":"2018","unstructured":"Birks JS, Harvey RJ (2018) Donepezil for dementia due to Alzheimer\u2019s disease. Cochrane Database Syst Rev 25:CD001190","journal-title":"Cochrane Database Syst Rev"},{"key":"1168_CR12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/cercor\/bht234","volume":"25","author":"SB Chapman","year":"2015","unstructured":"Chapman SB, Aslan S, Spence JS, Hart JJ Jr, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, DeFina LF, Lu H (2015) Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex 25:396\u2013405","journal-title":"Cereb Cortex"},{"key":"1168_CR13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fnhum.2016.00338","volume":"10","author":"SB Chapman","year":"2016","unstructured":"Chapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D\u2019Esposito M (2016) Distinct brain and behavioral benefits from cognitive vs. physical training: a randomized trial in aging adults. Front Hum Neurosci 10:338","journal-title":"Front Hum Neurosci"},{"key":"1168_CR14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11920-016-0721-2","volume":"18","author":"S-T Cheng","year":"2016","unstructured":"Cheng S-T (2016) Cognitive reserve and the prevention of dementia: the role of physical and cognitive activities. Curr Psychiatry Rep 18:85","journal-title":"Curr Psychiatry Rep"},{"key":"1168_CR15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0929-6646(09)60150-9","volume":"105","author":"M-J Chiu","year":"2006","unstructured":"Chiu M-J, Chen T-F, Yip P-K, Hua M-S, Tang L-Y (2006) Behavioral and psychologic symptoms in different types of dementia. J Formos Med Assoc 105:556\u2013562","journal-title":"J Formos Med Assoc"},{"key":"1168_CR16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2174\/1570159X14666160330105132","volume":"15","author":"S Cobianchi","year":"2017","unstructured":"Cobianchi S, Arbat-Plana A, Lopez-Alvarez VM, Navarro X (2017) Neuroprotective effects of exercise treatments after injury: the dual role of neurotrophic factors. Curr Neuropharmacol 15:495\u2013518","journal-title":"Curr Neuropharmacol"},{"key":"1168_CR17","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3945\/jn.109.113910","volume":"140","author":"GM Cole","year":"2010","unstructured":"Cole GM, Frautschy SA (2010) DHA may prevent age-related dementia. J Nutr 140:869\u2013874","journal-title":"J Nutr"},{"key":"1168_CR18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","volume":"22","author":"JC Cruz Hern\u00e1ndez","year":"2019","unstructured":"Cruz Hern\u00e1ndez JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M, Park L, Vinarcsik LK, Ivasyk I, Rivera DA, Kang Y, Cortes-Canteli M, Peyrounette M, Doyeux V, Smith A, Zhou J, Otte G, Beverly JD, Davenport E, Davit Y, Lin CP, Strickland S, Iadecola C, Lorthois S, Nishimura N, Schaffer CB (2019) Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer\u2019s disease mouse models. Nat Neurosci 22:413\u2013420","journal-title":"Nat Neurosci"},{"key":"1168_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","volume":"6","author":"JL Cummings","year":"2014","unstructured":"Cummings JL, Morstorf T, Zhong K (2014) Alzheimer\u2019s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther 6:37","journal-title":"Alzheimers Res Ther"},{"key":"1168_CR20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.neuropharm.2012.07.027","volume":"64","author":"DM Curlik 2nd","year":"2013","unstructured":"Curlik DM 2nd, Shors TJ (2013) Training your brain: do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus? Neuropharmacology 64:506\u2013514","journal-title":"Neuropharmacology"},{"key":"1168_CR21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nicl.2017.04.001","volume":"15","author":"SRB da Silva Filho","year":"2017","unstructured":"da Silva Filho SRB, Oliveira Barbosa JH, Rondinoni C, Dos Santos AC, Garrido Salmon CE, da Costa Lima NK, Ferriolli E, Moriguti JC (2017) Neuro-degeneration profile of Alzheimer\u2019s patients: a brain morphometry study. Neuroimage Clin 15:15\u201324","journal-title":"Neuroimage Clin"},{"key":"1168_CR22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuint.2011.02.010","volume":"58","author":"A Daccache","year":"2011","unstructured":"Daccache A, Lion C, Sibille N, Gerard M, Slomianny C, Lippens G, Cotelle P (2011) Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int 58:700\u2013707","journal-title":"Neurochem Int"},{"key":"1168_CR23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.psych.53.100901.135148","volume":"53","author":"RJ Davidson","year":"2002","unstructured":"Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K (2002) Depression: perspectives from affective neuroscience. Annu Rev Psychol 53:545\u2013574","journal-title":"Annu Rev Psychol"},{"key":"1168_CR24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archneurol.2010.144","volume":"67","author":"EE Devore","year":"2010","unstructured":"Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM (2010) Dietary antioxidants and long-term risk of dementia. Arch Neurol 67:819\u2013825","journal-title":"Arch Neurol"},{"key":"1168_CR25","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1001\/jamapsychiatry.2016.2657","volume":"73","author":"NJ Donovan","year":"2016","unstructured":"Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA (2016) Association of higher cortical amyloid burden with loneliness in cognitively normal older adults. JAMA Psychiatry 73:1230\u20131237","journal-title":"JAMA Psychiatry"},{"key":"1168_CR26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnagi.2015.00052","volume":"7","author":"SC Dyall","year":"2015","unstructured":"Dyall SC (2015) Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci 7:52","journal-title":"Front Aging Neurosci"},{"key":"1168_CR27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1073858410397054","volume":"18","author":"KI Erickson","year":"2012","unstructured":"Erickson KI, Miller DL, Roecklein KA (2012) The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist 18:82\u201397","journal-title":"Neuroscientist"},{"key":"1168_CR28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/0020764018776349","volume":"64","author":"E Erzen","year":"2018","unstructured":"Erzen E, Cikrikci O (2018) The effect of loneliness on depression: a meta-analysis. Int J Soc Psychiatry 64:427\u2013435","journal-title":"Int J Soc Psychiatry"},{"key":"1168_CR29","doi-asserted-by":"crossref","first-page":"226ra230","DOI":"10.1126\/scitranslmed.3007901","volume":"6","author":"AM Fagan","year":"2014","unstructured":"Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM (2014) Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer\u2019s disease. Sci Transl Med 6:226ra230","journal-title":"Sci Transl Med"},{"key":"1168_CR30","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","volume":"366","author":"CP Ferri","year":"2005","unstructured":"Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer\u2019s Disease I (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366:2112\u20132117","journal-title":"Lancet"},{"key":"1168_CR31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/1874609811003010046","volume":"3","author":"D Galimberti","year":"2010","unstructured":"Galimberti D, Scarpini E (2010) Treatment of Alzheimer\u2019s disease: symptomatic and disease-modifying approaches. Curr Aging Sci 3:46\u201356","journal-title":"Curr Aging Sci"},{"key":"1168_CR32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1176\/jnp.23.2.jnp149","volume":"23","author":"YE Geda","year":"2011","unstructured":"Geda YE, Topazian HM, Roberts LA, Roberts RO, Knopman DS, Pankratz VS, Christianson TJH, Boeve BF, Tangalos EG, Ivnik RJ, Petersen RC (2011) Engaging in cognitive activities, aging, and mild cognitive impairment: a population-based study. J Neuropsychiatry Clin Neurosci 23:149\u2013154","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"1168_CR33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.arr.2015.11.005","volume":"25","author":"C Groot","year":"2016","unstructured":"Groot C, Hooghiemstra AM, Raijmakers PGHM, van Berckel BNM, Scheltens P, Scherder EJA, van der Flier WM, Ossenkoppele R (2016) The effect of physical activity on cognitive function in patients with dementia: a meta-analysis of randomized control trials. Ageing Res Rev 25:13\u201323","journal-title":"Ageing Res Rev"},{"key":"1168_CR34","first-page":"189","volume":"72","author":"K Hager","year":"2007","unstructured":"Hager K, Kenklies M, McAfoose J, Engel J, Munch G (2007) Alpha-lipoic acid as a new treatment option for Alzheimer\u2019s disease\u2014a 48\u00a0months follow-up analysis. J Neural Transm Suppl 72:189\u2013193","journal-title":"J Neural Transm Suppl"},{"key":"1168_CR35","first-page":"211","volume":"3","author":"RA Hansen","year":"2008","unstructured":"Hansen RA, Gartlehner G, Webb AP, Morgan LC, Moore CG, Jonas DE (2008) Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer\u2019s disease: a systematic review and meta-analysis. Clin Interv Aging 3:211\u2013225","journal-title":"Clin Interv Aging"},{"key":"1168_CR36","doi-asserted-by":"crossref","first-page":"i6362","DOI":"10.1136\/bmj.i6362","volume":"355","author":"N Hawkes","year":"2016","unstructured":"Hawkes N (2016) Promise of new Alzheimer\u2019s drug is dashed after lack of evidence. BMJ 355:i6362","journal-title":"BMJ"},{"key":"1168_CR37","doi-asserted-by":"crossref","first-page":"j845","DOI":"10.1136\/bmj.j845","volume":"356","author":"N Hawkes","year":"2017","unstructured":"Hawkes N (2017) Merck ends trial of potential Alzheimer\u2019s drug verubecestat. BMJ 356:j845","journal-title":"BMJ"},{"key":"1168_CR38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.mehy.2003.11.028","volume":"62","author":"ST Henderson","year":"2004","unstructured":"Henderson ST (2004) High carbohydrate diets and Alzheimer\u2019s disease. Med Hypotheses 62:689\u2013700","journal-title":"Med Hypotheses"},{"key":"1168_CR39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev-psych-122216-011902","volume":"69","author":"J Holt-Lunstad","year":"2018","unstructured":"Holt-Lunstad J (2018) Why social relationships are important for physical health: a systems approach to understanding and modifying risk and protection. Annu Rev Psychol 69:437\u2013458","journal-title":"Annu Rev Psychol"},{"key":"1168_CR40","doi-asserted-by":"crossref","first-page":"512714","DOI":"10.1155\/2012\/512714","volume":"2012","author":"BD James","year":"2012","unstructured":"James BD, Glass TA, Caffo B, Bobb JF, Davatzikos C, Yousem D, Schwartz BS (2012) Association of social engagement with brain volumes assessed by structural MRI. J Aging Res 2012:512714","journal-title":"J Aging Res"},{"key":"1168_CR41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000022163","volume":"46","author":"AF Jorm","year":"2000","unstructured":"Jorm AF (2000) Is depression a risk factor for dementia or cognitive decline? A review. Gerontology 46:219\u2013227","journal-title":"Gerontology"},{"key":"1168_CR42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.plefa.2009.05.011","volume":"81","author":"PM Kris-Etherton","year":"2009","unstructured":"Kris-Etherton PM, Grieger JA, Etherton TD (2009) Dietary reference intakes for DHA and EPA. Prostaglandins Leukot Essent Fatty Acids 81:99\u2013104","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1168_CR43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.arr.2015.04.006","volume":"22","author":"JS Kuiper","year":"2015","unstructured":"Kuiper JS, Zuidersma M, Oude Voshaar RC, Zuidema SU, van den Heuvel ER, Stolk RP, Smidt N (2015) Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 22:39\u201357","journal-title":"Ageing Res Rev"},{"key":"1168_CR44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12888-016-1018-z","volume":"16","author":"OC Kuster","year":"2016","unstructured":"Kuster OC, Fissler P, Laptinskaya D, Thurm F, Scharpf A, Woll A, Kolassa S, Kramer AF, Elbert T, von Arnim CA, Kolassa IT (2016) Cognitive change is more positively associated with an active lifestyle than with training interventions in older adults at risk of dementia: a controlled interventional clinical trial. BMC Psychiatry 16:315","journal-title":"BMC Psychiatry"},{"key":"1168_CR45","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3390\/nu8120828","volume":"8","author":"V Lam","year":"2016","unstructured":"Lam V, Hackett M, Takechi R (2016) Antioxidants and dementia risk: consideration through a cerebrovascular perspective. Nutrients 8:828","journal-title":"Nutrients"},{"key":"1168_CR46","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archneur.58.3.498","volume":"58","author":"D Laurin","year":"2001","unstructured":"Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K (2001) Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58:498\u2013504","journal-title":"Arch Neurol"},{"key":"1168_CR47","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/jama.300.9.1027","volume":"300","author":"NT Lautenschlager","year":"2008","unstructured":"Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP (2008) Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 300:1027\u20131037","journal-title":"JAMA"},{"key":"1168_CR48","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1523\/JNEUROSCI.4225-04.2005","volume":"25","author":"GP Lim","year":"2005","unstructured":"Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM (2005) A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25:3032\u20133040","journal-title":"J Neurosci"},{"key":"1168_CR49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-45106-5_9","volume":"220","author":"B Lu","year":"2014","unstructured":"Lu B, Nagappan G, Lu Y (2014) BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol 220:223\u2013250","journal-title":"Handb Exp Pharmacol"},{"key":"1168_CR50","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF02982565","volume":"12","author":"JA Luchsinger","year":"2008","unstructured":"Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R (2008) Higher folate intake is related to lower risk of Alzheimer\u2019s disease in the elderly. J Nutr Health Aging 12:648\u2013650","journal-title":"J Nutr Health Aging"},{"key":"1168_CR51","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s12603-018-1054-0","volume":"22","author":"L Ma","year":"2018","unstructured":"Ma L, Sun F, Tang Z (2018) Social frailty is associated with physical functioning, cognition, and depression, and predicts mortality. J Nutr Health Aging 22:989\u2013995","journal-title":"J Nutr Health Aging"},{"key":"1168_CR52","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.addr.2008.04.015","volume":"60","author":"A Maczurek","year":"2008","unstructured":"Maczurek A, Hager K, Kenklies M, Sharman M, Martins R, Engel J, Carlson DA, Munch G (2008) Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer\u2019s disease. Adv Drug Deliv Rev 60:1463\u20131470","journal-title":"Adv Drug Deliv Rev"},{"key":"1168_CR53","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1186\/s12889-015-2426-6","volume":"15","author":"RE Marioni","year":"2015","unstructured":"Marioni RE, Proust-Lima C, Amieva H, Brayne C, Matthews FE, Dartigues J-F, Jacqmin-Gadda H (2015) Social activity, cognitive decline and dementia risk: a 20-year prospective cohort study. BMC Public Health 15:1089","journal-title":"BMC Public Health"},{"key":"1168_CR54","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/13543784.2017.1323868","volume":"26","author":"D Mehta","year":"2017","unstructured":"Mehta D, Jackson R, Paul G, Shi J, Sabbagh M (2017) Why do trials for Alzheimer\u2019s disease drugs keep failing? A discontinued drug perspective for 2010-2015. Expert Opin Investig Drugs 26:735\u2013739","journal-title":"Expert Opin Investig Drugs"},{"key":"1168_CR55","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0361-9230(99)00182-3","volume":"50","author":"RG Morris","year":"1999","unstructured":"Morris RG (1999) D.O. Hebb: the organization of behavior, Wiley: New York; 1949. Brain Res Bull 50:437","journal-title":"Brain Res Bull"},{"key":"1168_CR56","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/an.112.002535","volume":"3","author":"MS Morris","year":"2012","unstructured":"Morris MS (2012) The role of B vitamins in preventing and treating cognitive impairment and decline. Adv Nutr 3:801\u2013812","journal-title":"Adv Nutr"},{"key":"1168_CR57","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1136\/jnnp.2003.025858","volume":"75","author":"MC Morris","year":"2004","unstructured":"Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, Bennett DA, Wilson RS, Aggarwal N (2004) Dietary niacin and the risk of incident Alzheimer\u2019s disease and of cognitive decline. J Neurol Neurosurg Psychiatry 75:1093\u20131099","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1168_CR58","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","volume":"11","author":"MC Morris","year":"2015","unstructured":"Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT (2015) MIND diet associated with reduced incidence of Alzheimer\u2019s disease. Alzheimers Dement 11:1007\u20131014","journal-title":"Alzheimers Dement"},{"key":"1168_CR59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0301-0082(00)00014-9","volume":"63","author":"MG Murer","year":"2001","unstructured":"Murer MG, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer\u2019s disease and Parkinson\u2019s disease. Prog Neurobiol 63:71\u2013124","journal-title":"Prog Neurobiol"},{"key":"1168_CR60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0306-4522(94)90202-X","volume":"60","author":"KD Murray","year":"1994","unstructured":"Murray KD, Gall CM, Jones EG, Isackson PJ (1994) Differential regulation of brain-derived neurotrophic factor and type II calcium\/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer\u2019s disease. Neuroscience 60:37\u201348","journal-title":"Neuroscience"},{"key":"1168_CR61","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","volume":"385","author":"T Ngandu","year":"2015","unstructured":"Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, Backman L, Hanninen T, Jula A, Laatikainen T, Lindstrom J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M (2015) A 2\u00a0year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 385:2255\u20132263","journal-title":"Lancet"},{"key":"1168_CR62","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jnc.14034","volume":"142","author":"SM Nigam","year":"2017","unstructured":"Nigam SM, Xu S, Kritikou JS, Marosi K, Brodin L, Mattson MP (2017) Exercise and BDNF reduce Abeta production by enhancing alpha-secretase processing of APP. J Neurochem 142:286\u2013296","journal-title":"J Neurochem"},{"key":"1168_CR63","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","volume":"63","author":"RL Ownby","year":"2006","unstructured":"Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63:530\u2013538","journal-title":"Arch Gen Psychiatry"},{"key":"1168_CR64","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12126-018-9325-y","volume":"43","author":"A Pakstis","year":"2018","unstructured":"Pakstis A, Kim J, Bhargava V (2018) Association between social support and health of aging adults with dementia. Ageing Int 43:477\u2013495","journal-title":"Ageing Int"},{"key":"1168_CR65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tips.2010.12.007","volume":"32","author":"AM Palmer","year":"2011","unstructured":"Palmer AM (2011) Neuroprotective therapeutics for Alzheimer\u2019s disease: progress and prospects. Trends Pharmacol Sci 32:141\u2013147","journal-title":"Trends Pharmacol Sci"},{"key":"1168_CR66","volume-title":"World Alzheimer report 2015\u2014the global impact of dementia: an analysis of prevalence, incidence, cost and trends","author":"MWA Prince","year":"2015","unstructured":"Prince MWA, Guerchet M, Ali G, Wu Y, Prina M (2015) World Alzheimer report 2015\u2014the global impact of dementia: an analysis of prevalence, incidence, cost and trends. Alzheimer\u2019s Disease International, London"},{"key":"1168_CR67","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3945\/ajcn.117.157834","volume":"106","author":"B Qin","year":"2017","unstructured":"Qin B, Xun P, Jacobs DR Jr, Zhu N, Daviglus ML, Reis JP, Steffen LM, Van Horn L, Sidney S, He K (2017) Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr 106:1032\u20131040","journal-title":"Am J Clin Nutr"},{"key":"1168_CR68","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbx087","author":"SB Rafnsson","year":"2017","unstructured":"Rafnsson SB, Orrell M, d\u2019Orsi E, Hogervorst E, Steptoe A (2017) Loneliness, social integration, and incident dementia over 6\u00a0years: prospective findings from the english longitudinal study of ageing. J Gerontol B. \nhttps:\/\/doi.org\/10.1093\/geronb\/gbx087","journal-title":"J Gerontol B"},{"key":"1168_CR69","first-page":"650983","volume":"2013","author":"JL Reay","year":"2013","unstructured":"Reay JL, Smith MA, Riby LM (2013) B vitamins and cognitive performance in older adults: review. ISRN Nutr 2013:650983","journal-title":"ISRN Nutr"},{"key":"1168_CR70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jgs.12607","volume":"62","author":"GW Rebok","year":"2014","unstructured":"Rebok GW, Ball K, Guey LT, Jones RN, Kim HY, King JW, Marsiske M, Morris JN, Tennstedt SL, Unverzagt FW, Willis SL (2014) Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc 62:16\u201324","journal-title":"J Am Geriatr Soc"},{"key":"1168_CR71","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0197-4580(03)00087-3","volume":"25","author":"MA Reger","year":"2004","unstructured":"Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S (2004) Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25:311\u2013314","journal-title":"Neurobiol Aging"},{"key":"1168_CR72","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/jech-2017-209811","volume":"72","author":"T Saito","year":"2018","unstructured":"Saito T, Murata C, Saito M, Takeda T, Kondo K (2018) Influence of social relationship domains and their combinations on incident dementia: a prospective cohort study. J Epidemiol Community Health 72:7\u201312","journal-title":"J Epidemiol Community Health"},{"key":"1168_CR73","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/1570159X14666160412150223","volume":"15","author":"D Saraulli","year":"2017","unstructured":"Saraulli D, Costanzi M, Mastrorilli V, Farioli-Vecchioli S (2017) The long run: neuroprotective effects of physical exercise on adult neurogenesis from youth to old age. Curr Neuropharmacol 15:519\u2013533","journal-title":"Curr Neuropharmacol"},{"key":"1168_CR74","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ana.20854","volume":"59","author":"N Scarmeas","year":"2006","unstructured":"Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer\u2019s disease. Ann Neurol 59:912\u2013921","journal-title":"Ann Neurol"},{"key":"1168_CR75","first-page":"216","volume":"66","author":"N Scarmeas","year":"2009","unstructured":"Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA (2009) Mediterranean diet and mild cognitive impairment. Arch Neurol 66:216\u2013225","journal-title":"Arch Neurol"},{"key":"1168_CR76","first-page":"26","volume":"5","author":"C Schwarz","year":"2018","unstructured":"Schwarz C, Wirth M, Gerischer L, Grittner U, Witte AV, Kobe T, Floel A (2018) Effects of omega-3 fatty acids on resting cerebral perfusion in patients with mild cognitive impairment: a randomized controlled trial. J Prev Alzheimers Dis 5:26\u201330","journal-title":"J Prev Alzheimers Dis"},{"issue":"Suppl 2","key":"1168_CR77","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1111\/j.1753-4887.2010.00346.x","volume":"68","author":"J Selhub","year":"2010","unstructured":"Selhub J, Troen A, Rosenberg IH (2010) B vitamins and the aging brain. Nutr Rev 68(Suppl 2):S112\u2013S118","journal-title":"Nutr Rev"},{"key":"1168_CR78","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","volume":"6","author":"DJ Selkoe","year":"1991","unstructured":"Selkoe DJ (1991) The molecular pathology of Alzheimer\u2019s disease. Neuron 6:487\u2013498","journal-title":"Neuron"},{"key":"1168_CR79","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S1474-4422(17)30332-0","volume":"16","author":"H Soininen","year":"2017","unstructured":"Soininen H, Solomon A, Visser PJ, Hendrix SB, Blennow K, Kivipelto M, Hartmann T, Hallikainen I, Hallikainen M, Helisalmi S, Lappalainen T, Liu Y, Paajanen T, Wahlund L-O, Freund-Levi Y, Andreasen N, Hagman G, Lindblom S, Fassbender K, Riemenschneider M, Grimm MOW, Klees-Rollmann A, Luley M, Lyros E, Schomburg R, Kennel J, Ramelli D, Fr\u00f6lich L, Hausner L, Laske C, Leyhe T, Mychajliw C, Koehler N, Schiekofer S, Kl\u00fcnemann H, Schr\u00f6der J, L\u00fctjohann D, Scheltens P, van Rossum I, Scheltens N, Bertens D, ten Kate M, Barkhof F, Henselmans JML, Roks G, van Hees AMJ, Ellison N (2017) 24-month intervention with a specific multinutrient in people with prodromal Alzheimer\u2019s disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol 16:965\u2013975","journal-title":"Lancet Neurol"},{"key":"1168_CR80","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","volume":"7","author":"RA Sperling","year":"2011","unstructured":"Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH (2011) Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7:280\u2013292","journal-title":"Alzheimers Dement"},{"key":"1168_CR81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","volume":"3","author":"D Swanson","year":"2012","unstructured":"Swanson D, Block R, Mousa SA (2012) Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr 3:1\u20137","journal-title":"Adv Nutr"},{"key":"1168_CR82","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s12877-018-1014-x","volume":"18","author":"CF Tagliabue","year":"2018","unstructured":"Tagliabue CF, Guzzetti S, Gualco G, Boccolieri G, Boccolieri A, Smith S, Daini R (2018) A group study on the effects of a short multi-domain cognitive training in healthy elderly Italian people. BMC Geriatr 18:321","journal-title":"BMC Geriatr"},{"key":"1168_CR83","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fnsys.2015.00044","volume":"9","author":"F Taya","year":"2015","unstructured":"Taya F, Sun Y, Babiloni F, Thakor N, Bezerianos A (2015) Brain enhancement through cognitive training: a new insight from brain connectome. Front Syst Neurosci 9:44","journal-title":"Front Syst Neurosci"},{"key":"1168_CR84","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(16)30950-3","volume":"388","author":"EPM van Charante","year":"2016","unstructured":"van Charante EPM, Richard E, Eurelings LS, van Dalen J-W, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA (2016) Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet 388:797\u2013805","journal-title":"Lancet"},{"key":"1168_CR85","first-page":"13","volume":"1","author":"B Vellas","year":"2014","unstructured":"Vellas B, Carrie I, Gillette-Guyonnet S, Touchon J, Dantoine T, Dartigues JF, Cuffi MN, Bordes S, Gasnier Y, Robert P, Bories L, Rouaud O, Desclaux F, Sudres K, Bonnefoy M, Pesce A, Dufouil C, Lehericy S, Chupin M, Mangin JF, Payoux P, Adel D, Legrand P, Catheline D, Kanony C, Zaim M, Molinier L, Costa N, Delrieu J, Voisin T, Faisant C, Lala F, Nourhash\u00e9mi F, Rolland Y, Van Kan GA, Dupuy C, Cantet C, Cestac P, Belleville S, Willis S, Cesari M, Weiner MW, Soto ME, Ousset PJ, Andrieu S (2014) MAPT study: a multidomain approach for preventing Alzheimer\u2019s disease: design and baseline data. J Prev Alzheimers Dis 1:13\u201322","journal-title":"J Prev Alzheimers Dis"},{"key":"1168_CR86","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/1533317511418956","volume":"26","author":"M Venturelli","year":"2011","unstructured":"Venturelli M, Scarsini R, Schena F (2011) Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Demen 26:381\u2013388","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"1168_CR87","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1056\/NEJMoa022252","volume":"348","author":"J Verghese","year":"2003","unstructured":"Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H (2003) Leisure activities and the risk of dementia in the elderly. N Engl J Med 348:2508\u20132516","journal-title":"N Engl J Med"},{"key":"1168_CR88","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1212\/WNL.0b013e31829c5e8a","volume":"81","author":"RS Wilson","year":"2013","unstructured":"Wilson RS, Boyle PA, Yu L, Barnes LL, Schneider JA, Bennett DA (2013) Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology 81:314\u2013321","journal-title":"Neurology"},{"key":"1168_CR89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2016.07.150","volume":"13","author":"A Wimo","year":"2017","unstructured":"Wimo A, Guerchet M, Ali GC, Wu YT, Prina AM, Winblad B, Jonsson L, Liu Z, Prince M (2017) The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimers Dement 13:1\u20137","journal-title":"Alzheimers Dement"},{"key":"1168_CR90","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3390\/ijms18091965","volume":"18","author":"Y Yamazaki","year":"2017","unstructured":"Yamazaki Y, Kanekiyo T (2017) Blood-brain barrier dysfunction and the pathogenesis of Alzheimer\u2019s disease. Int J Mol Sci 18:1965","journal-title":"Int J Mol Sci"},{"key":"1168_CR91","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/gerona\/60.8.1039","volume":"60","author":"KW Young","year":"2005","unstructured":"Young KW, Greenwood CE, van Reekum R, Binns MA (2005) A randomized, crossover trial of high-carbohydrate foods in nursing home residents with Alzheimer\u2019s disease: associations among intervention response, body mass index, and behavioral and cognitive function. J Gerontol A 60:1039\u20131045","journal-title":"J Gerontol A"},{"key":"1168_CR92","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jalz.2010.01.013","volume":"6","author":"K Yurko-Mauro","year":"2010","unstructured":"Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M (2010) Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 6:456\u2013464","journal-title":"Alzheimers Dement"},{"key":"1168_CR93","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2017.12.025","volume":"666","author":"J Zhang","year":"2018","unstructured":"Zhang J, Guo Y, Wang Y, Song L, Zhang R, Du Y (2018) Long-term treadmill exercise attenuates Abeta burdens and astrocyte activation in APP\/PS1 mouse model of Alzheimer\u2019s disease. Neurosci Lett 666:70\u201377","journal-title":"Neurosci Lett"},{"issue":"Suppl 7","key":"1168_CR94","first-page":"119","volume":"59","author":"JA Zoladz","year":"2008","unstructured":"Zoladz JA, Pilc A, Majerczak J, Grandys M, Zapart-Bukowska J, Duda K (2008) Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol 59(Suppl 7):119\u2013132","journal-title":"J Physiol Pharmacol"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-019-01168-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12272-019-01168-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-019-01168-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T06:26:49Z","timestamp":1603175209000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12272-019-01168-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":94,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,1]]}},"alternative-id":["1168"],"URL":"https:\/\/doi.org\/10.1007\/s12272-019-01168-3","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"assertion":[{"value":"9 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}