{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:09:32Z","timestamp":1781719772080,"version":"3.54.5"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2019R1A2C1004636"],"award-info":[{"award-number":["NRF-2019R1A2C1004636"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["MAFRA"],"award-info":[{"award-number":["MAFRA"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["316007-5"],"award-info":[{"award-number":["316007-5"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s12272-020-01273-8","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T10:03:00Z","timestamp":1603188180000},"page":"985-996","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Emerging roles of ferroptosis in liver pathophysiology"],"prefix":"10.1007","volume":"43","author":[{"given":"Kyu Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam Seok","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hwan","family":"Ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"1273_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","volume":"69","author":"NC Andrews","year":"2007","unstructured":"Andrews NC, Schmidt PJ (2007) Iron homeostasis. Annu Rev Physiol 69:69\u201385. https:\/\/doi.org\/10.1146\/annurev.physiol.69.031905.164337","journal-title":"Annu Rev Physiol"},{"key":"1273_CR2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.bbrc.2017.07.136","volume":"491","author":"T Bai","year":"2017","unstructured":"Bai T, Wang S, Zhao Y, Zhu R, Wang W, Sun Y (2017) Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun 491:919\u2013925. https:\/\/doi.org\/10.1016\/j.bbrc.2017.07.136","journal-title":"Biochem Biophys Res Commun"},{"key":"1273_CR3","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1089\/ars.2009.2597","volume":"12","author":"VN Bochkov","year":"2010","unstructured":"Bochkov VN, Oskolkova OV, Birukov KG, Levonen AL, Binder CJ, Stockl J (2010) Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal 12:1009\u20131059. https:\/\/doi.org\/10.1089\/ars.2009.2597","journal-title":"Antioxid Redox Signal"},{"key":"1273_CR4","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","volume":"41","author":"AR Bogdan","year":"2016","unstructured":"Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y (2016) Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci 41:274\u2013286. https:\/\/doi.org\/10.1016\/j.tibs.2015.11.012","journal-title":"Trends Biochem Sci"},{"key":"1273_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1476-5381.2011.01480.x","volume":"165","author":"RJ Bridges","year":"2012","unstructured":"Bridges RJ, Natale NR, Patel SA (2012) System Xc\u2212 cystine\/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. Br J Pharmacol 165:20\u201334. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01480.x","journal-title":"Br J Pharmacol"},{"key":"1273_CR6","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","volume":"1830","author":"R Brigelius-Flohe","year":"2013","unstructured":"Brigelius-Flohe R, Maiorino M (2013) Glutathione peroxidases. Biochim Biophys Acta 1830:3289\u20133303. https:\/\/doi.org\/10.1016\/j.bbagen.2012.11.020","journal-title":"Biochim Biophys Acta"},{"key":"1273_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","volume":"416","author":"LC Chang","year":"2018","unstructured":"Chang LC, Chiang SK, Chen SE, Yu YL, Chou RH, Chang WC (2018) Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis. Cancer Lett 416:124\u2013137. https:\/\/doi.org\/10.1016\/j.canlet.2017.12.025","journal-title":"Cancer Lett"},{"key":"1273_CR8","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1021\/cr040077w","volume":"107","author":"Z Cheng","year":"2007","unstructured":"Cheng Z, Li Y (2007) What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update. Chem Rev 107:748\u2013766. https:\/\/doi.org\/10.1021\/cr040077w","journal-title":"Chem Rev"},{"key":"1273_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","volume":"10","author":"SJ Dixon","year":"2014","unstructured":"Dixon SJ, Stockwell BR (2014) The role of iron and reactive oxygen species in cell death. Nat Chem Biol 10:9\u201317. https:\/\/doi.org\/10.1038\/nchembio.1416","journal-title":"Nat Chem Biol"},{"key":"1273_CR10","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"1273_CR11","doi-asserted-by":"publisher","first-page":"e02523","DOI":"10.7554\/eLife.02523","volume":"3","author":"SJ Dixon","year":"2014","unstructured":"Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR (2014) Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife 3:e02523. https:\/\/doi.org\/10.7554\/eLife.02523","journal-title":"Elife"},{"key":"1273_CR12","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","volume":"10","author":"SJ Dixon","year":"2015","unstructured":"Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR (2015) Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem Biol 10:1604\u20131609. https:\/\/doi.org\/10.1021\/acschembio.5b00245","journal-title":"ACS Chem Biol"},{"key":"1273_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s1535-6108(03)00050-3","volume":"3","author":"S Dolma","year":"2003","unstructured":"Dolma S, Lessnick SL, Hahn WC, Stockwell BR (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3:285\u2013296. https:\/\/doi.org\/10.1016\/s1535-6108(03)00050-3","journal-title":"Cancer Cell"},{"key":"1273_CR14","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F (2019) Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA 116:2672\u20132680. https:\/\/doi.org\/10.1073\/pnas.1821022116","journal-title":"Proc Natl Acad Sci USA"},{"key":"1273_CR15","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1111\/bph.12416","volume":"171","author":"AA Fatokun","year":"2014","unstructured":"Fatokun AA, Dawson VL, Dawson TM (2014) Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 171:2000\u20132016. https:\/\/doi.org\/10.1111\/bph.12416","journal-title":"Br J Pharmacol"},{"key":"1273_CR16","doi-asserted-by":"publisher","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","volume":"16","author":"H Feng","year":"2018","unstructured":"Feng H, Stockwell BR (2018) Unsolved mysteries: how does lipid peroxidation cause ferroptosis? PLoS Biol 16:e2006203. https:\/\/doi.org\/10.1371\/journal.pbio.2006203","journal-title":"PLoS Biol"},{"key":"1273_CR17","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/s41568-019-0149-1","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Forster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O\u2019donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180\u20131191. https:\/\/doi.org\/10.1038\/s41568-019-0149-1","journal-title":"Nat Cell Biol"},{"key":"1273_CR18","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","volume":"19","author":"JP Friedmann Angeli","year":"2019","unstructured":"Friedmann Angeli JP, Krysko DV, Conrad M (2019) Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer 19:405\u2013414. https:\/\/doi.org\/10.1038\/s41568-019-0149-1","journal-title":"Nat Rev Cancer"},{"key":"1273_CR19","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.bbrc.2018.07.078","volume":"503","author":"H Gao","year":"2018","unstructured":"Gao H, Bai Y, Jia Y, Zhao Y, Kang R, Tang D, Dai E (2018) Ferroptosis is a lysosomal cell death process. Biochem Biophys Res Commun 503:1550\u20131556. https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.078","journal-title":"Biochem Biophys Res Commun"},{"issue":"354\u2013363","key":"1273_CR20","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.molcel.2018.10.042","volume":"73","author":"M Gao","year":"2019","unstructured":"Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, Jiang X (2019) Role of mitochondria in ferroptosis. Mol Cell 73(354\u2013363):e3. https:\/\/doi.org\/10.1016\/j.molcel.2018.10.042","journal-title":"Mol Cell"},{"key":"1273_CR21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","volume":"14","author":"MM Gaschler","year":"2018","unstructured":"Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR (2018a) FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol 14:507\u2013515. https:\/\/doi.org\/10.1038\/s41589-018-0031-6","journal-title":"Nat Chem Biol"},{"key":"1273_CR22","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1021\/acschembio.8b00199","volume":"13","author":"MM Gaschler","year":"2018","unstructured":"Gaschler MM, Hu F, Feng H, Linkermann A, Min W, Stockwell BR (2018b) Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis. ACS Chem Biol 13:1013\u20131020. https:\/\/doi.org\/10.1021\/acschembio.8b00199","journal-title":"ACS Chem Biol"},{"key":"1273_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4143\/crt.2016.572","volume":"50","author":"J Guo","year":"2018","unstructured":"Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G (2018) Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat 50:445\u2013460. https:\/\/doi.org\/10.4143\/crt.2016.572","journal-title":"Cancer Res Treat"},{"key":"1273_CR24","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","volume":"35","author":"B Hassannia","year":"2019","unstructured":"Hassannia B, Vandenabeele P, Vanden Berghe T (2019) Targeting ferroptosis to iron out cancer. Cancer Cell 35:830\u2013849. https:\/\/doi.org\/10.1016\/j.ccell.2019.04.002","journal-title":"Cancer Cell"},{"key":"1273_CR25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/cdd.2015.93","volume":"23","author":"M Hayano","year":"2016","unstructured":"Hayano M, Yang WS, Corn CK, Pagano NC, Stockwell BR (2016) Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ 23:270\u2013278. https:\/\/doi.org\/10.1038\/cdd.2015.93","journal-title":"Cell Death Differ"},{"key":"1273_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","volume":"142","author":"MW Hentze","year":"2010","unstructured":"Hentze MW, Muckenthaler MU, Galy B, Camaschella C (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142:24\u201338. https:\/\/doi.org\/10.1016\/j.cell.2010.06.028","journal-title":"Cell"},{"key":"1273_CR27","doi-asserted-by":"publisher","first-page":"115164","DOI":"10.18632\/oncotarget.23046","volume":"8","author":"SH Hong","year":"2017","unstructured":"Hong SH, Lee DH, Lee YS, Jo MJ, Jeong YA, Kwon WT, Choudry HA, Bartlett DL, Lee YJ (2017) Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. Oncotarget 8:115164\u2013115178. https:\/\/doi.org\/10.18632\/oncotarget.23046","journal-title":"Oncotarget"},{"key":"1273_CR28","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","volume":"12","author":"W Hou","year":"2016","unstructured":"Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, Kang R, Tang D (2016) Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12:1425\u20131428. https:\/\/doi.org\/10.1080\/15548627.2016.1187366","journal-title":"Autophagy"},{"key":"1273_CR29","doi-asserted-by":"crossref","first-page":"21591","DOI":"10.1016\/S0021-9258(20)88224-6","volume":"264","author":"LD Isenman","year":"1989","unstructured":"Isenman LD, Dice JF (1989) Secretion of intact proteins and peptide fragments by lysosomal pathways of protein degradation. J Biol Chem 264:21591\u201321596","journal-title":"J Biol Chem"},{"key":"1273_CR30","doi-asserted-by":"crossref","first-page":"12387","DOI":"10.1016\/S0021-9258(18)43284-X","volume":"256","author":"T Ishii","year":"1981","unstructured":"Ishii T, Bannai S, Sugita Y (1981) Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine. J Biol Chem 256:12387\u201312392","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"1273_CR31","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/ajt.14559","volume":"18","author":"WR Kim","year":"2018","unstructured":"Kim WR, Lake JR, Smith JM, Schladt DP, Skeans MA, Harper AM, Wainright JL, Snyder JJ, Israni AK, Kasiske BL (2018) OPTN\/SRTR 2016 annual data report: liver. Am J Transpl 18(Suppl 1):172\u2013253. https:\/\/doi.org\/10.1111\/ajt.14559","journal-title":"Am J Transpl"},{"key":"1273_CR32","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ajpath.2013.10.028","volume":"184","author":"ES Knudsen","year":"2014","unstructured":"Knudsen ES, Gopal P, Singal AG (2014) The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy. Am J Pathol 184:574\u2013583. https:\/\/doi.org\/10.1016\/j.ajpath.2013.10.028","journal-title":"Am J Pathol"},{"key":"1273_CR33","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/j.biopha.2018.11.030","volume":"109","author":"Z Kong","year":"2019","unstructured":"Kong Z, Liu R, Cheng Y (2019) Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother 109:2043\u20132053. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.030","journal-title":"Biomed Pharmacother"},{"issue":"Suppl 3","key":"1273_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1478-3231.2011.02587.x","volume":"31","author":"L Kramer","year":"2011","unstructured":"Kramer L, Kodras K (2011) Detoxification as a treatment goal in hepatic failure. Liver Int 31(Suppl 3):1\u20134. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02587.x","journal-title":"Liver Int"},{"key":"1273_CR35","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","volume":"3","author":"Z Li","year":"2006","unstructured":"Li Z, Agellon LB, Allen TM, Umeda M, Jewell L, Mason A, Vance DE (2006) The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab 3:321\u2013331. https:\/\/doi.org\/10.1016\/j.cmet.2006.03.007","journal-title":"Cell Metab"},{"key":"1273_CR36","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","volume":"26","author":"Y Li","year":"2019","unstructured":"Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J, Tian X (2019) Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion. Cell Death Differ 26:2284\u20132299. https:\/\/doi.org\/10.1038\/s41418-019-0299-4","journal-title":"Cell Death Differ"},{"key":"1273_CR37","doi-asserted-by":"publisher","first-page":"4902","DOI":"10.1002\/anie.201712027","volume":"57","author":"LS Lin","year":"2018","unstructured":"Lin LS, Song J, Song L, Ke K, Liu Y, Zhou Z, Shen Z, Li J, Yang Z, Tang W, Niu G, Yang HH, Chen X (2018) Simultaneous fenton-like ion delivery and glutathione depletion by MnO2-based nanoagent to enhance chemodynamic therapy. Angew Chem Int Ed Engl 57:4902\u20134906. https:\/\/doi.org\/10.1002\/anie.201712027","journal-title":"Angew Chem Int Ed Engl"},{"key":"1273_CR38","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"JM Llovet","year":"2008","unstructured":"Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, De Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378\u2013390. https:\/\/doi.org\/10.1056\/NEJMoa0708857","journal-title":"N Engl J Med"},{"key":"1273_CR39","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1002\/ijc.28159","volume":"133","author":"C Louandre","year":"2013","unstructured":"Louandre C, Ezzoukhry Z, Godin C, Barbare JC, Maziere JC, Chauffert B, Galmiche A (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int J Cancer 133:1732\u20131742. https:\/\/doi.org\/10.1002\/ijc.28159","journal-title":"Int J Cancer"},{"key":"1273_CR40","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","volume":"356","author":"C Louandre","year":"2015","unstructured":"Louandre C, Marcq I, Bouhlal H, Lachaier E, Godin C, Saidak Z, Francois C, Chatelain D, Debuysscher V, Barbare JC, Chauffert B, Galmiche A (2015) The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells. Cancer Lett 356:971\u2013977. https:\/\/doi.org\/10.1016\/j.canlet.2014.11.014","journal-title":"Cancer Lett"},{"key":"1273_CR41","doi-asserted-by":"publisher","first-page":"12438","DOI":"10.1073\/pnas.91.26.12438","volume":"91","author":"Y Luo","year":"1994","unstructured":"Luo Y, Han Z, Chin SM, Linn S (1994) Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA. Proc Natl Acad Sci USA 91:12438\u201312442. https:\/\/doi.org\/10.1073\/pnas.91.26.12438","journal-title":"Proc Natl Acad Sci USA"},{"key":"1273_CR42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmed.2007.12.003","volume":"14","author":"F Marra","year":"2008","unstructured":"Marra F, Gastaldelli A, Svegliati Baroni G, Tell G, Tiribelli C (2008) Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med 14:72\u201381. https:\/\/doi.org\/10.1016\/j.molmed.2007.12.003","journal-title":"Trends Mol Med"},{"key":"1273_CR43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-011-0864-8","volume":"42","author":"GJ Mcbean","year":"2012","unstructured":"Mcbean GJ (2012) The transsulfuration pathway: a source of cysteine for glutathione in astrocytes. Amino Acids 42:199\u2013205. https:\/\/doi.org\/10.1007\/s00726-011-0864-8","journal-title":"Amino Acids"},{"key":"1273_CR44","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","volume":"4","author":"I Mederacke","year":"2013","unstructured":"Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, Pradere JP, Schwabe RF (2013) Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 4:2823. https:\/\/doi.org\/10.1038\/ncomms3823","journal-title":"Nat Commun"},{"key":"1273_CR45","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nprot.2015.017","volume":"10","author":"I Mederacke","year":"2015","unstructured":"Mederacke I, Dapito DH, Affo S, Uchinami H, Schwabe RF (2015) High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers. Nat Protoc 10:305\u2013315. https:\/\/doi.org\/10.1038\/nprot.2015.017","journal-title":"Nat Protoc"},{"key":"1273_CR46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.tcm.2004.08.003","volume":"14","author":"B Moosmann","year":"2004","unstructured":"Moosmann B, Behl C (2004) Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway. Trends Cardiovasc Med 14:273\u2013281. https:\/\/doi.org\/10.1016\/j.tcm.2004.08.003","journal-title":"Trends Cardiovasc Med"},{"key":"1273_CR47","doi-asserted-by":"publisher","first-page":"114665","DOI":"10.1016\/j.taap.2019.114665","volume":"379","author":"SJ Park","year":"2019","unstructured":"Park SJ, Cho SS, Kim KM, Yang JH, Kim JH, Jeong EH, Yang JW, Han CY, Ku SK, Cho IJ, Ki SH (2019) Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Toxicol Appl Pharmacol 379:114665. https:\/\/doi.org\/10.1016\/j.taap.2019.114665","journal-title":"Toxicol Appl Pharmacol"},{"key":"1273_CR48","doi-asserted-by":"publisher","first-page":"16185","DOI":"10.1038\/s41598-019-52837-8","volume":"9","author":"W Qi","year":"2019","unstructured":"Qi W, Li Z, Xia L, Dai J, Zhang Q, Wu C, Xu S (2019) LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. Sci Rep 9:16185. https:\/\/doi.org\/10.1038\/s41598-019-52837-8","journal-title":"Sci Rep"},{"key":"1273_CR49","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ajpath.2019.09.011","volume":"190","author":"J Qi","year":"2020","unstructured":"Qi J, Kim JW, Zhou Z, Lim CW, Kim B (2020) Ferroptosis affects the progression of nonalcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice. Am J Pathol 190:68\u201381. https:\/\/doi.org\/10.1016\/j.ajpath.2019.09.011","journal-title":"Am J Pathol"},{"key":"1273_CR50","doi-asserted-by":"publisher","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","volume":"274","author":"H Sato","year":"1999","unstructured":"Sato H, Tamba M, Ishii T, Bannai S (1999) Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 274:11455\u201311458. https:\/\/doi.org\/10.1074\/jbc.274.17.11455","journal-title":"J Biol Chem"},{"key":"1273_CR51","doi-asserted-by":"publisher","first-page":"109633","DOI":"10.1016\/j.cellsig.2020.109633","volume":"72","author":"Y Shang","year":"2020","unstructured":"Shang Y, Luo M, Yao F, Wang S, Yuan Z, Yang Y (2020) Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Cell Signal 72:109633. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109633","journal-title":"Cell Signal"},{"key":"1273_CR52","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nchembio.2079","volume":"12","author":"K Shimada","year":"2016","unstructured":"Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 12:497\u2013503. https:\/\/doi.org\/10.1038\/nchembio.2079","journal-title":"Nat Chem Biol"},{"key":"1273_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.R800046200","volume":"284","author":"H Shindou","year":"2009","unstructured":"Shindou H, Shimizu T (2009) Acyl-CoA: lysophospholipid acyltransferases. J Biol Chem 284:1\u20135. https:\/\/doi.org\/10.1074\/jbc.R800046200","journal-title":"J Biol Chem"},{"key":"1273_CR54","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1021\/ja411006a","volume":"136","author":"R Skouta","year":"2014","unstructured":"Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc 136:4551\u20134556. https:\/\/doi.org\/10.1021\/ja411006a","journal-title":"J Am Chem Soc"},{"key":"1273_CR55","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3181\/0710-MR-287","volume":"233","author":"E Soupene","year":"2008","unstructured":"Soupene E, Kuypers FA (2008) Mammalian long-chain acyl-CoA synthetases. Exp Biol Med 233:507\u2013521. https:\/\/doi.org\/10.3181\/0710-MR-287","journal-title":"Exp Biol Med"},{"key":"1273_CR56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.biopha.2018.06.060","volume":"106","author":"M Sui","year":"2018","unstructured":"Sui M, Jiang X, Chen J, Yang H, Zhu Y (2018) Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway. Biomed Pharmacother 106:125\u2013133. https:\/\/doi.org\/10.1016\/j.biopha.2018.06.060","journal-title":"Biomed Pharmacother"},{"key":"1273_CR57","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/hep.28574","volume":"64","author":"X Sun","year":"2016","unstructured":"Sun X, Niu X, Chen R, He W, Chen D, Kang R, Tang D (2016a) Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology 64:488\u2013500. https:\/\/doi.org\/10.1002\/hep.28574","journal-title":"Hepatology"},{"key":"1273_CR58","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","volume":"63","author":"X Sun","year":"2016","unstructured":"Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D (2016b) Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63:173\u2013184. https:\/\/doi.org\/10.1002\/hep.28251","journal-title":"Hepatology"},{"key":"1273_CR59","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1096\/fasebj.13.13.1800","volume":"13","author":"DM Suttner","year":"1999","unstructured":"Suttner DM, Dennery PA (1999) Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J 13:1800\u20131809. https:\/\/doi.org\/10.1096\/fasebj.13.13.1800","journal-title":"FASEB J"},{"key":"1273_CR60","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1042\/BJ20150658","volume":"473","author":"S Torii","year":"2016","unstructured":"Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, Suzuki T, Mori M, Yoshimoto Y, Takeuchi T, Yamada K (2016) An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem J 473:769\u2013777. https:\/\/doi.org\/10.1042\/BJ20150658","journal-title":"Biochem J"},{"key":"1273_CR61","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41419-019-1678-y","volume":"10","author":"S Tsurusaki","year":"2019","unstructured":"Tsurusaki S, Tsuchiya Y, Koumura T, Nakasone M, Sakamoto T, Matsuoka M, Imai H, Yuet-Yin Kok C, Okochi H, Nakano H, Miyajima A, Tanaka M (2019) Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. Cell Death Dis 10:449. https:\/\/doi.org\/10.1038\/s41419-019-1678-y","journal-title":"Cell Death Dis"},{"key":"1273_CR62","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-phyto-080516-035537","volume":"55","author":"EH Verbon","year":"2017","unstructured":"Verbon EH, Trapet PL, Stringlis IA, Kruijs S, Bakker P, Pieterse CMJ (2017) Iron and immunity. Annu Rev Phytopathol 55:355\u2013375. https:\/\/doi.org\/10.1146\/annurev-phyto-080516-035537","journal-title":"Annu Rev Phytopathol"},{"key":"1273_CR63","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/s41419-018-1063-2","volume":"9","author":"L Wang","year":"2018","unstructured":"Wang L, Cai H, Hu Y, Liu F, Huang S, Zhou Y, Yu J, Xu J, Wu F (2018) A pharmacological probe identifies cystathionine beta-synthase as a new negative regulator for ferroptosis. Cell Death Dis 9:1005. https:\/\/doi.org\/10.1038\/s41419-018-1063-2","journal-title":"Cell Death Dis"},{"key":"1273_CR64","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/iub.1895","volume":"71","author":"L Wang","year":"2019","unstructured":"Wang L, Zhang Z, Li M, Wang F, Jia Y, Zhang F, Shao J, Chen A, Zheng S (2019a) P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. IUBMB Life 71:45\u201356. https:\/\/doi.org\/10.1002\/iub.1895","journal-title":"IUBMB Life"},{"key":"1273_CR65","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.3892\/mmr.2019.10660","volume":"20","author":"Y Wang","year":"2019","unstructured":"Wang Y, Chen Q, Shi C, Jiao F, Gong Z (2019b) Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress. Mol Med Rep 20:4081\u20134090. https:\/\/doi.org\/10.3892\/mmr.2019.10660","journal-title":"Mol Med Rep"},{"key":"1273_CR66","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/j.bmcl.2011.09.047","volume":"22","author":"M Weiwer","year":"2012","unstructured":"Weiwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, Macpherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett 22:1822\u20131826. https:\/\/doi.org\/10.1016\/j.bmcl.2011.09.047","journal-title":"Bioorg Med Chem Lett"},{"key":"1273_CR67","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1073\/pnas.1819728116","volume":"116","author":"Z Wu","year":"2019","unstructured":"Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J (2019) Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci USA 116:2996\u20133005. https:\/\/doi.org\/10.1073\/pnas.1819728116","journal-title":"Proc Natl Acad Sci USA"},{"key":"1273_CR68","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Y Xie","year":"2016","unstructured":"Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D (2016) Ferroptosis: process and function. Cell Death Differ 23:369\u2013379. https:\/\/doi.org\/10.1038\/cdd.2015.158","journal-title":"Cell Death Differ"},{"key":"1273_CR69","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1172\/JCI26373","volume":"115","author":"C Xu","year":"2005","unstructured":"Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Investig 115:2656\u20132664. https:\/\/doi.org\/10.1172\/JCI26373","journal-title":"J Clin Investig"},{"key":"1273_CR70","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature05859","volume":"447","author":"N Yagoda","year":"2007","unstructured":"Yagoda N, Von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447:864\u2013868. https:\/\/doi.org\/10.1038\/nature05859","journal-title":"Nature"},{"key":"1273_CR71","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41419-020-2334-2","volume":"11","author":"N Yamada","year":"2020","unstructured":"Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S, Mizuta K, Sakuma Y, Sata N, Takahashi M (2020a) Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis 11:144. https:\/\/doi.org\/10.1038\/s41419-020-2334-2","journal-title":"Cell Death Dis"},{"key":"1273_CR72","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/ajt.15773","volume":"20","author":"N Yamada","year":"2020","unstructured":"Yamada N, Karasawa T, Wakiya T, Sadatomo A, Ito H, Kamata R, Watanabe S, Komada T, Kimura H, Sanada Y, Sakuma Y, Mizuta K, Ohno N, Sata N, Takahashi M (2020b) Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis. Am J Transpl 20:1606\u20131618. https:\/\/doi.org\/10.1111\/ajt.15773","journal-title":"Am J Transpl"},{"key":"1273_CR73","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR (2008) Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol 15:234\u2013245. https:\/\/doi.org\/10.1016\/j.chembiol.2008.02.010","journal-title":"Chem Biol"},{"key":"1273_CR74","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"WS Yang","year":"2016","unstructured":"Yang WS, Stockwell BR (2016) Ferroptosis: death by lipid peroxidation. Trends Cell Biol 26:165\u2013176. https:\/\/doi.org\/10.1016\/j.tcb.2015.10.014","journal-title":"Trends Cell Biol"},{"key":"1273_CR75","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1021\/ml200195s","volume":"3","author":"WS Yang","year":"2012","unstructured":"Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR (2012) Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency. ACS Med Chem Lett 3:35\u201338. https:\/\/doi.org\/10.1021\/ml200195s","journal-title":"ACS Med Chem Lett"},{"key":"1273_CR76","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, Sriramaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317\u2013331. https:\/\/doi.org\/10.1016\/j.cell.2013.12.010","journal-title":"Cell"},{"key":"1273_CR77","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","volume":"113","author":"WS Yang","year":"2016","unstructured":"Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA 113:E4966\u2013E4975. https:\/\/doi.org\/10.1073\/pnas.1603244113","journal-title":"Proc Natl Acad Sci USA"},{"key":"1273_CR78","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.2019002907","volume":"136","author":"Y Yu","year":"2020","unstructured":"Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, Wang J, Wu Q, Fang X, Duan L, Wang S, Wang K, An P, Shao T, Chung RT, Zheng S, Min J, Wang F (2020) Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood 136:726\u2013739. https:\/\/doi.org\/10.1182\/blood.2019002907","journal-title":"Blood"},{"key":"1273_CR79","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","volume":"20","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B (2018) BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20:1181\u20131192. https:\/\/doi.org\/10.1038\/s41556-018-0178-0","journal-title":"Nat Cell Biol"},{"key":"1273_CR80","doi-asserted-by":"publisher","first-page":"101211","DOI":"10.1016\/j.redox.2019.101211","volume":"24","author":"X Zhang","year":"2019","unstructured":"Zhang X, Du L, Qiao Y, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, Guo S, Yang Y, Ma L, Yu Y, Pan Q, Sun F, Wang J (2019a) Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol 24:101211. https:\/\/doi.org\/10.1016\/j.redox.2019.101211","journal-title":"Redox Biol"},{"issue":"623\u2013633","key":"1273_CR81","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.chembiol.2019.01.008","volume":"26","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Tan H, Daniels JD, Zandkarimi F, Liu H, Brown LM, Uchida K, O\u2019connor OA, Stockwell BR (2019b) Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model. Cell Chem Biol 26(623\u2013633):e9. https:\/\/doi.org\/10.1016\/j.chembiol.2019.01.008","journal-title":"Cell Chem Biol"},{"key":"1273_CR82","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","volume":"16","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, Ding H, Tan S, Chen A, Zhang F, Zheng S (2019c) RNA-binding protein ZFP36\/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. Autophagy 16:1482\u20131505. https:\/\/doi.org\/10.1080\/15548627.2019.1687985","journal-title":"Autophagy"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-020-01273-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12272-020-01273-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-020-01273-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T12:36:39Z","timestamp":1634733399000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12272-020-01273-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":82,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1273"],"URL":"https:\/\/doi.org\/10.1007\/s12272-020-01273-8","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"6 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no competing interests in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}