{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:15:08Z","timestamp":1782206108966,"version":"3.54.5"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11-12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372936"],"award-info":[{"award-number":["82372936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2022CXA009"],"award-info":[{"award-number":["2022CXA009"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Funds Project for Innovation of Science and Technology, Fujian province","award":["2021Y9067"],"award-info":[{"award-number":["2021Y9067"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12272-025-01587-5","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:29:09Z","timestamp":1763980149000},"page":"1382-1398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of RBPJ transcription complex promotes IL-17 and IFN-\u03b3 secretion by CD4\u207a T cells in hepatocellular carcinoma"],"prefix":"10.1007","volume":"48","author":[{"given":"Yuxin","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banglun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-5254","authenticated-orcid":false,"given":"Nanhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"1587_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.immuni.2013.07.006","volume":"39","author":"W Bailis","year":"2013","unstructured":"Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS (2013) Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 39:148\u2013159. https:\/\/doi.org\/10.1016\/j.immuni.2013.07.006","journal-title":"Immunity"},{"key":"1587_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235\u2013238. https:\/\/doi.org\/10.1038\/nature04753","journal-title":"Nature"},{"key":"1587_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/35025220","volume":"407","author":"P Carmeliet","year":"2000","unstructured":"Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249\u2013257. https:\/\/doi.org\/10.1038\/35025220","journal-title":"Nature"},{"key":"1587_CR4","doi-asserted-by":"publisher","first-page":"9321","DOI":"10.1093\/nar\/gky787","volume":"46","author":"S Carrasco Pro","year":"2018","unstructured":"Carrasco Pro S, Dafonte Imedio A, Santoso CS, Gan KA, Sewell JA, Martinez M, Sereda R, Mehta S, Fuxman Bass JI (2018) Global landscape of mouse and human cytokine transcriptional regulation. Nucleic Acids Res 46:9321\u20139337. https:\/\/doi.org\/10.1093\/nar\/gky787","journal-title":"Nucleic Acids Res"},{"key":"1587_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/imm.13280","volume":"163","author":"S Cerboni","year":"2021","unstructured":"Cerboni S, Gehrmann U, Preite S, Mitra S (2021) Cytokine-regulated Th17 plasticity in human health and diseases. Immunology 163:3\u201318. https:\/\/doi.org\/10.1111\/imm.13280","journal-title":"Immunology"},{"key":"1587_CR6","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.immuni.2020.07.012","volume":"53","author":"D Chang","year":"2020","unstructured":"Chang D, Xing Q, Su Y, Zhao X, Xu W, Wang X, Dong C (2020) The conserved non-coding sequences CNS6 and CNS9 control cytokine-induced Rorc transcription during T helper 17 cell differentiation. Immunity 53:614-626.e4. https:\/\/doi.org\/10.1016\/j.immuni.2020.07.012","journal-title":"Immunity"},{"key":"1587_CR7","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2017.1373234","volume":"7","author":"CL Chen","year":"2017","unstructured":"Chen CL, Wang Y, Huang CY, Zhou ZQ, Zhao JJ, Zhang XF, Pan QZ, Wu JX, Weng DS, Tang Y, Zhu Q, Yuan LP, Xia JC (2017) IL-17 induces antitumor immunity by promoting beneficial neutrophil recruitment and activation in esophageal squamous cell carcinoma. Oncoimmunology 7:e1373234. https:\/\/doi.org\/10.1080\/2162402x.2017.1373234","journal-title":"Oncoimmunology"},{"key":"1587_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","volume":"151","author":"M Ciofani","year":"2012","unstructured":"Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkhurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR (2012) A validated regulatory network for Th17 cell specification. Cell 151:289\u2013303. https:\/\/doi.org\/10.1016\/j.cell.2012.09.016","journal-title":"Cell"},{"key":"1587_CR9","doi-asserted-by":"publisher","first-page":"19408","DOI":"10.1073\/pnas.2005010117","volume":"117","author":"MP Crawford","year":"2020","unstructured":"Crawford MP, Sinha S, Renavikar PS, Borcherding N, Karandikar NJ (2020) CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: effector resistance to immune suppression. Proc Natl Acad Sci U S A 117:19408\u201319414. https:\/\/doi.org\/10.1073\/pnas.2005010117","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1587_CR10","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","volume":"146","author":"EV Dang","year":"2011","unstructured":"Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F (2011) Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1. Cell 146:772\u2013784. https:\/\/doi.org\/10.1016\/j.cell.2011.07.033","journal-title":"Cell"},{"key":"1587_CR11","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1182\/blood-2008-03-143222","volume":"112","author":"KM Dhodapkar","year":"2008","unstructured":"Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, Vesole D, Jagannath S, Dhodapkar MV (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112:2878\u20132885. https:\/\/doi.org\/10.1182\/blood-2008-03-143222","journal-title":"Blood"},{"key":"1587_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12088","volume":"7","author":"R D\u00edAZ-TRELLES","year":"2016","unstructured":"D\u00edAZ-TRELLES R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M (2016) Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 7:12088. https:\/\/doi.org\/10.1038\/ncomms12088","journal-title":"Nat Commun"},{"key":"1587_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14649","volume":"8","author":"S Downs-Canner","year":"2017","unstructured":"Downs-Canner S, Berkey S, Delgoffe GM, Edwards RP, Curiel T, Odunsi K, Bartlett DL, Obermajer N (2017) Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) T(reg) cells are a source of tumour-associated T(reg) cells. Nat Commun 8:14649. https:\/\/doi.org\/10.1038\/ncomms14649","journal-title":"Nat Commun"},{"key":"1587_CR14","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.1093\/nar\/gkac601","volume":"50","author":"T Friedrich","year":"2022","unstructured":"Friedrich T, Ferrante F, Pioger L, Nist A, Stiewe T, Andrau JC, Bartkuhn M, Giaimo BD, Borggrefe T (2022) Notch-dependent and -independent functions of transcription factor RBPJ. Nucleic Acids Res 50:7925\u20137937. https:\/\/doi.org\/10.1093\/nar\/gkac601","journal-title":"Nucleic Acids Res"},{"key":"1587_CR15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001374","volume":"3","author":"S Furuta","year":"2011","unstructured":"Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH (2011) IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med 3:78ra31. https:\/\/doi.org\/10.1126\/scitranslmed.3001374","journal-title":"Sci Transl Med"},{"key":"1587_CR16","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1126\/science.adn5820","volume":"384","author":"X Guo","year":"2024","unstructured":"Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y (2024) Molecular mechanism of substrate recognition and cleavage by human \u03b3-secretase. Science 384:1091\u20131095. https:\/\/doi.org\/10.1126\/science.adn5820","journal-title":"Science"},{"key":"1587_CR17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ccell.2022.04.004","volume":"40","author":"Y Hailemichael","year":"2022","unstructured":"Hailemichael Y, Johnson DH, Abdel-Wahab N, Foo WC, Bentebibel SE, Daher M, Haymaker C, Wani K, Saberian C, Ogata D, Kim ST, Nurieva R, Lazar AJ, Abu-Sbeih H, Fa\u2019ak F, Mathew A, Wang Y, Falohun A, Trinh V, Zobniw C, Spillson C, Burks JK, Awiwi M, Elsayes K, Soto LS, Melendez BD, Davies MA, Wargo J, Curry J, Yee C, Lizee G, Singh S, Sharma P, Allison JP, Hwu P, Ekmekcioglu S, Diab A (2022) Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity. Cancer Cell 40:509-523.e6. https:\/\/doi.org\/10.1016\/j.ccell.2022.04.004","journal-title":"Cancer Cell"},{"key":"1587_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46948-5","volume":"9","author":"C Hurtado","year":"2019","unstructured":"Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M (2019) Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep 9:10811. https:\/\/doi.org\/10.1038\/s41598-019-46948-5","journal-title":"Sci Rep"},{"key":"1587_CR19","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nm.4466","volume":"24","author":"C Krieg","year":"2018","unstructured":"Krieg C, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Weber LM, Dummer R, Robinson MD, Levesque MP, Becher B (2018) High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nat Med 24:144\u2013153. https:\/\/doi.org\/10.1038\/nm.4466","journal-title":"Nat Med"},{"key":"1587_CR20","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1182\/blood-2009-03-208249","volume":"114","author":"I Kryczek","year":"2009","unstructured":"Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W (2009) Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114:1141\u20131149. https:\/\/doi.org\/10.1182\/blood-2009-03-208249","journal-title":"Blood"},{"key":"1587_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1084\/jem.20121192","volume":"212","author":"I Kulic","year":"2015","unstructured":"Kulic I, Robertson G, Chang L, Baker JH, Lockwood WW, Mok W, Fuller M, Fournier M, Wong N, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thomson TA, Hirst M, Minchinton AI, Lam WL, Jones S, Marra M, Karsan A (2015) Loss of the notch effector RBPJ promotes tumorigenesis. J Exp Med 212:37\u201352. https:\/\/doi.org\/10.1084\/jem.20121192","journal-title":"J Exp Med"},{"key":"1587_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","volume":"30","author":"YK Lee","year":"2009","unstructured":"Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT (2009) Late developmental plasticity in the T helper 17 lineage. Immunity 30:92\u2013107. https:\/\/doi.org\/10.1016\/j.immuni.2008.11.005","journal-title":"Immunity"},{"key":"1587_CR23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2412120121","volume":"121","author":"X Lei","year":"2024","unstructured":"Lei X, Xiao R, Chen Z, Ren J, Zhao W, Tang W, Wen K, Zhu Y, Li X, Ouyang S, Xu A, Hu Y, Bi E (2024) Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-\u03b3-induced type I interferon response network via IRF7. Proc Natl Acad Sci U S A 121:e2412120121. https:\/\/doi.org\/10.1073\/pnas.2412120121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1587_CR24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev-immunol-042718-041447","volume":"37","author":"JX Lin","year":"2019","unstructured":"Lin JX, Leonard WJ (2019) Fine-tuning cytokine signals. Annu Rev Immunol 37:295\u2013324. https:\/\/doi.org\/10.1146\/annurev-immunol-042718-041447","journal-title":"Annu Rev Immunol"},{"key":"1587_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s12094-014-1197-3","volume":"17","author":"Y Lin","year":"2015","unstructured":"Lin Y, Xu J, Su H, Zhong W, Yuan Y, Yu Z, Fang Y, Zhou H, Li C, Huang K (2015) Interleukin-17 is a favorable prognostic marker for colorectal cancer. Clin Transl Oncol 17:50\u201356. https:\/\/doi.org\/10.1007\/s12094-014-1197-3","journal-title":"Clin Transl Oncol"},{"key":"1587_CR26","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.celrep.2016.05.088","volume":"16","author":"G Meyer Zu Horste","year":"2016","unstructured":"Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK (2016) RBPJ controls development of pathogenic Th17 cells by regulating IL-23 receptor expression. Cell Rep 16:392\u2013404. https:\/\/doi.org\/10.1016\/j.celrep.2016.05.088","journal-title":"Cell Rep"},{"key":"1587_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102647","volume":"19","author":"T Moser","year":"2020","unstructured":"Moser T, AKG\u00fcN K, Proschmann U, Sellner J, Ziemssen T (2020) The role of TH17 cells in multiple sclerosis: therapeutic implications. Autoimmun Rev 19:102647. https:\/\/doi.org\/10.1016\/j.autrev.2020.102647","journal-title":"Autoimmun Rev"},{"key":"1587_CR28","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1126\/science.1059835","volume":"292","author":"AC Mullen","year":"2001","unstructured":"Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL (2001) Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907\u20131910. https:\/\/doi.org\/10.1126\/science.1059835","journal-title":"Science"},{"key":"1587_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04521-x","volume":"6","author":"B Pan","year":"2023","unstructured":"Pan B, Wang Z, Zhang X, Shen S, Ke X, Qiu J, Yao Y, Wu X, Wang X, Tang N (2023) Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8(+) T cells in hepatocellular carcinoma. Commun Biol 6:123. https:\/\/doi.org\/10.1038\/s42003-023-04521-x","journal-title":"Commun Biol"},{"key":"1587_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.jaci.2016.11.045","volume":"140","author":"M Paroni","year":"2017","unstructured":"Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J (2017) Recognition of viral and self-antigens by T(H)1 and T(H)1\/T(H)17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses. J Allergy Clin Immunol 140:797\u2013808. https:\/\/doi.org\/10.1016\/j.jaci.2016.11.045","journal-title":"J Allergy Clin Immunol"},{"key":"1587_CR31","doi-asserted-by":"publisher","first-page":"12055","DOI":"10.1093\/nar\/gkaa1055","volume":"48","author":"CS Santoso","year":"2020","unstructured":"Santoso CS, Li Z, Lal S, Yuan S, Gan KA, Agosto LM, Liu X, Pro SC, Sewell JA, Henderson A, Atianand MK, Fuxman Bass JI (2020) Comprehensive mapping of the human cytokine gene regulatory network. Nucleic Acids Res 48:12055\u201312073. https:\/\/doi.org\/10.1093\/nar\/gkaa1055","journal-title":"Nucleic Acids Res"},{"key":"1587_CR32","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.ccell.2019.04.003","volume":"35","author":"M Segovia","year":"2019","unstructured":"Segovia M, Russo S, Jeldres M, Mahmoud YD, Perez V, Duhalde M, Charnet P, Rousset M, Victoria S, Veigas F, Louvet C, Vanhove B, Floto RA, Anegon I, Cuturi MC, Girotti MR, Rabinovich GA, Hill M (2019) Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation. Cancer Cell 35:767-781.e6. https:\/\/doi.org\/10.1016\/j.ccell.2019.04.003","journal-title":"Cancer Cell"},{"key":"1587_CR33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.it.2014.03.003","volume":"35","author":"ST Smale","year":"2014","unstructured":"Smale ST (2014) Transcriptional regulation in the immune system: a status report. Trends Immunol 35:190\u2013194. https:\/\/doi.org\/10.1016\/j.it.2014.03.003","journal-title":"Trends Immunol"},{"key":"1587_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205072","author":"Y Tamai","year":"2023","unstructured":"Tamai Y, Fujiwara N, Tanaka T, Mizuno S, Nakagawa H (2023) Combination therapy of immune checkpoint inhibitors with locoregional therapy for hepatocellular carcinoma. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers15205072","journal-title":"Cancers (Basel)"},{"key":"1587_CR35","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190456","author":"GA Vitiello","year":"2020","unstructured":"Vitiello GA, Miller G (2020) Targeting the interleukin-17 immune axis for cancer immunotherapy. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20190456","journal-title":"J Exp Med"},{"key":"1587_CR36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.gendis.2020.01.014","volume":"7","author":"W Wang","year":"2020","unstructured":"Wang W, Wei C (2020) Advances in the early diagnosis of hepatocellular carcinoma. Genes Dis 7:308\u2013319. https:\/\/doi.org\/10.1016\/j.gendis.2020.01.014","journal-title":"Genes Dis"},{"key":"1587_CR37","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20170457","volume":"215","author":"JS Weinstein","year":"2018","unstructured":"Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J (2018) STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med 215:337\u2013355. https:\/\/doi.org\/10.1084\/jem.20170457","journal-title":"J Exp Med"},{"key":"1587_CR38","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/436307","volume":"2013","author":"D Wu","year":"2013","unstructured":"Wu D, Wu P, Huang Q, Liu Y, Ye J, Huang J (2013) Interleukin-17: a promoter in colorectal cancer progression. Clin Dev Immunol 2013:436307. https:\/\/doi.org\/10.1155\/2013\/436307","journal-title":"Clin Dev Immunol"},{"key":"1587_CR39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-023-06733-x","volume":"624","author":"P Zhou","year":"2023","unstructured":"Zhou P, Shi H, Huang H, Sun X, Yuan S, Chapman NM, Connelly JP, Lim SA, Saravia J, Kc A, Pruett-Miller SM, Chi H (2023) Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer. Nature 624:154\u2013163. https:\/\/doi.org\/10.1038\/s41586-023-06733-x","journal-title":"Nature"},{"key":"1587_CR40","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jhep.2020.09.032","volume":"74","author":"C Zhu","year":"2021","unstructured":"Zhu C, Ho YJ, Salomao MA, Dapito DH, Bartolome A, Schwabe RF, Lee JS, Lowe SW, Pajvani UB (2021) Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. J Hepatol 74:613\u2013626. https:\/\/doi.org\/10.1016\/j.jhep.2020.09.032","journal-title":"J Hepatol"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-025-01587-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12272-025-01587-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-025-01587-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T16:35:30Z","timestamp":1764952530000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12272-025-01587-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":40,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1587"],"URL":"https:\/\/doi.org\/10.1007\/s12272-025-01587-5","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}