{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:47Z","timestamp":1792783307569,"version":"4.5.0"},"reference-count":212,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2023YFD1800801"],"award-info":[{"award-number":["2023YFD1800801"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant numbers 32373046"],"award-info":[{"award-number":["grant numbers 32373046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Pharm. Res."],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12272-026-01598-w","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:05:14Z","timestamp":1771898714000},"page":"197-222","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroinflammation and blood\u2013brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies"],"prefix":"10.1007","volume":"49","author":[{"given":"Xiaochun","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-0509","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"1","key":"1598_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11481-025-10240-3","volume":"20","author":"SK Abate","year":"2025","unstructured":"Abate SK, Soni R, Jena P, Banerjee A, Garabadu D (2025) Rutin attenuates virus entry and replication and exerts neuroprotection in experimental models of Japanese encephalitis. J Neuroimmune Pharmacol 20(1):80. https:\/\/doi.org\/10.1007\/s11481-025-10240-3","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"1598_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10571-004-1374-y","volume":"25","author":"NJ Abbott","year":"2005","unstructured":"Abbott NJ (2005) Dynamics of cns barriers: evolution, differentiation, and modulation. Cell Mol Neurobiol 25(1):5\u201323. https:\/\/doi.org\/10.1007\/s10571-004-1374-y","journal-title":"Cell Mol Neurobiol"},{"issue":"7","key":"1598_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069465","volume":"8","author":"T Agrawal","year":"2013","unstructured":"Agrawal T, Sharvani V, Nair D, Medigeshi GR (2013) Japanese encephalitis virus disrupts cell-cell junctions and affects the epithelial permeability barrier functions. PLoS ONE 8(7):e69465. https:\/\/doi.org\/10.1371\/journal.pone.0069465","journal-title":"PLoS ONE"},{"issue":"9","key":"1598_CR4","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1128\/JVI.02586-15","volume":"90","author":"U Ashraf","year":"2016","unstructured":"Ashraf U, Zhu B, Ye J et al (2016) Microrna-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting rnf11. J Virol 90(9):4780\u20134795. https:\/\/doi.org\/10.1128\/JVI.02586-15","journal-title":"J Virol"},{"issue":"1","key":"1598_CR5","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1080\/21505594.2021.1899674","volume":"12","author":"U Ashraf","year":"2021","unstructured":"Ashraf U, Ding Z, Deng S, Ye J, Cao S, Chen Z (2021) Pathogenicity and virulence of Japanese encephalitis virus: neuroinflammation and neuronal cell damage. Virulence 12(1):968\u2013980. https:\/\/doi.org\/10.1080\/21505594.2021.1899674","journal-title":"Virulence"},{"key":"1598_CR6","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fimmu.2017.00160","volume":"8","author":"M Awais","year":"2017","unstructured":"Awais M, Wang K, Lin X et al (2017) Tlr7 deficiency leads to tlr8 compensative regulation of immune response against JEV in mice. Front Immunol 8:160. https:\/\/doi.org\/10.3389\/fimmu.2017.00160","journal-title":"Front Immunol"},{"key":"1598_CR7","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19693.1","volume":"8","author":"A Banerjee","year":"2019","unstructured":"Banerjee A, Tripathi A (2019) Recent advances in understanding Japanese encephalitis. F1000Res 8:F1000-F1915. https:\/\/doi.org\/10.12688\/f1000research.19693.1","journal-title":"F1000Res"},{"issue":"4","key":"1598_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrd.2015.21","volume":"15","author":"WA Banks","year":"2016","unstructured":"Banks WA (2016) From blood-brain barrier to blood-brain interface: new opportunities for cns drug delivery. Nat Rev Drug Discov 15(4):275\u2013292. https:\/\/doi.org\/10.1038\/nrd.2015.21","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"1598_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause K (2007) The nox family of ros-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87(1):245\u2013313. https:\/\/doi.org\/10.1152\/physrev.00044.2005","journal-title":"Physiol Rev"},{"issue":"785","key":"1598_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1136\/pgmj.67.785.247","volume":"67","author":"M Bharadwaj","year":"1991","unstructured":"Bharadwaj M, Prakash V, Mathur A, Chaturvedi UC (1991) Prognostic significance of serum iron levels in cases of Japanese encephalitis. Postgrad Med J 67(785):247\u2013249. https:\/\/doi.org\/10.1136\/pgmj.67.785.247","journal-title":"Postgrad Med J"},{"issue":"6","key":"1598_CR11","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1007\/s12010-021-03526-8","volume":"193","author":"A Bhattacharjee","year":"2021","unstructured":"Bhattacharjee A, Chaudhuri R, Dash JJ, Saha M, Choudhury L, Roy S (2021) Pre-treatment with scopolamine naturally suppresses Japanese encephalitis viral load in embryonated chick through regulation of multiple signaling pathways. Appl Biochem Biotechnol 193(6):1654\u20131674. https:\/\/doi.org\/10.1007\/s12010-021-03526-8","journal-title":"Appl Biochem Biotechnol"},{"issue":"10","key":"1598_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-023-05883-7","volume":"168","author":"A Bhattacharjee","year":"2023","unstructured":"Bhattacharjee A, Naga R, Saha M, Karmakar S, Pal A, Roy S (2023) Viral inhibitory potential of hyoscyamine in japanese encephalitis virus-infected embryonated chicken eggs involving multiple signaling pathways. Arch Virol 168(10):264. https:\/\/doi.org\/10.1007\/s00705-023-05883-7","journal-title":"Arch Virol"},{"issue":"1","key":"1598_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0486-5","volume":"8","author":"P Bian","year":"2017","unstructured":"Bian P, Ye C, Zheng X et al (2017) Mesenchymal stem cells alleviate japanese encephalitis virus-induced neuroinflammation and mortality. Stem Cell Res Ther 8(1):38. https:\/\/doi.org\/10.1186\/s13287-017-0486-5","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"1598_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03225-1","volume":"21","author":"P Bian","year":"2024","unstructured":"Bian P, Zhang H, Ye C et al (2024) Gas6 as a potential target to alleviate neuroinflammation during japanese encephalitis in mouse models. J Neuroinflammation 21(1):231. https:\/\/doi.org\/10.1186\/s12974-024-03225-1","journal-title":"J Neuroinflammation"},{"issue":"10","key":"1598_CR15","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2471\/BLT.10.085233","volume":"89","author":"GL Campbell","year":"2011","unstructured":"Campbell GL, Hills SL, Fischer M et al (2011) Estimated global incidence of japanese encephalitis: a systematic review. Bull World Health Organ 89(10):766\u2013774. https:\/\/doi.org\/10.2471\/BLT.10.085233","journal-title":"Bull World Health Organ"},{"issue":"4","key":"1598_CR16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12264-020-00620-5","volume":"37","author":"Y Cao","year":"2021","unstructured":"Cao Y, Li Y, He C et al (2021) Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage. Neurosci Bull 37(4):535\u2013549. https:\/\/doi.org\/10.1007\/s12264-020-00620-5","journal-title":"Neurosci Bull"},{"key":"1598_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114316","volume":"183","author":"M Carty","year":"2021","unstructured":"Carty M, Guy C, Bowie AG (2021) Detection of viral infections by innate immunity. Biochem Pharmacol 183:114316. https:\/\/doi.org\/10.1016\/j.bcp.2020.114316","journal-title":"Biochem Pharmacol"},{"key":"1598_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107101","volume":"201","author":"C Ceci","year":"2024","unstructured":"Ceci C, Lacal PM, Barbaccia ML, Mercuri NB, Graziani G, Ledonne A (2024) The vegfs\/vegfrs system in Alzheimer\u2019s and Parkinson\u2019s diseases: pathophysiological roles and therapeutic implications. Pharmacol Res 201:107101. https:\/\/doi.org\/10.1016\/j.phrs.2024.107101","journal-title":"Pharmacol Res"},{"issue":"1","key":"1598_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.micinf.2005.06.014","volume":"8","author":"T Chang","year":"2006","unstructured":"Chang T, Liao C, Lin Y (2006) Flavivirus induces interferon-beta gene expression through a pathway involving rig-i-dependent irf-3 and pi3k-dependent nf-kappab activation. Microbes Infect 8(1):157\u2013171. https:\/\/doi.org\/10.1016\/j.micinf.2005.06.014","journal-title":"Microbes Infect"},{"issue":"9","key":"1598_CR20","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s12272-013-0325-x","volume":"37","author":"S Chang","year":"2014","unstructured":"Chang S, Huang S, Lin Y, Tsou Y, Lin C (2014) Antiviral activity of rheum palmatum methanol extract and chrysophanol against japanese encephalitis virus. Arch Pharm Res 37(9):1117\u20131123. https:\/\/doi.org\/10.1007\/s12272-013-0325-x","journal-title":"Arch Pharm Res"},{"issue":"11","key":"1598_CR21","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1002\/glia.22857","volume":"63","author":"C Chang","year":"2015","unstructured":"Chang C, Li J, Chen W et al (2015) Disruption of in vitro endothelial barrier integrity by japanese encephalitis virus-infected astrocytes. Glia 63(11):1915\u20131932. https:\/\/doi.org\/10.1002\/glia.22857","journal-title":"Glia"},{"key":"1598_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bbi.2017.07.003","volume":"66","author":"C Chang","year":"2017","unstructured":"Chang C, Li J, Ou Y et al (2017) Interplay of inflammatory gene expression in pericytes following japanese encephalitis virus infection. Brain Behav Immun 66:230\u2013243. https:\/\/doi.org\/10.1016\/j.bbi.2017.07.003","journal-title":"Brain Behav Immun"},{"key":"1598_CR23","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbi.2021.01.012","volume":"93","author":"C Chang","year":"2021","unstructured":"Chang C, Wu C, Wang J et al (2021) Dha attenuated japanese encephalitis virus infection-induced neuroinflammation and neuronal cell death in cultured rat neuron\/glia. Brain Behav Immun 93:194\u2013205. https:\/\/doi.org\/10.1016\/j.bbi.2021.01.012","journal-title":"Brain Behav Immun"},{"issue":"1","key":"1598_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03288-0","volume":"21","author":"C Chang","year":"2024","unstructured":"Chang C, Wu C, Tzeng C et al (2024) Nmda receptor blockade attenuates japanese encephalitis virus infection-induced microglia activation. J Neuroinflammation 21(1):291. https:\/\/doi.org\/10.1186\/s12974-024-03288-0","journal-title":"J Neuroinflammation"},{"key":"1598_CR25","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.physbeh.2017.01.028","volume":"171","author":"PS Chauhan","year":"2017","unstructured":"Chauhan PS, Misra UK, Kalita J (2017) A study of glutamate levels, nr1, nr2a, nr2b receptors and oxidative stress in rat model of japanese encephalitis. Physiol Behav 171:256\u2013267. https:\/\/doi.org\/10.1016\/j.physbeh.2017.01.028","journal-title":"Physiol Behav"},{"issue":"2","key":"1598_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neuint.2010.12.009","volume":"58","author":"C Chen","year":"2011","unstructured":"Chen C, Ou Y, Chang C et al (2011) Tnf-\u03b1 and il-1\u03b2 mediate japanese encephalitis virus-induced rantes gene expression in astrocytes. Neurochem Int 58(2):234\u2013242. https:\/\/doi.org\/10.1016\/j.neuint.2010.12.009","journal-title":"Neurochem Int"},{"issue":"3","key":"1598_CR27","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/glia.22282","volume":"60","author":"C Chen","year":"2012","unstructured":"Chen C, Ou Y, Chang C et al (2012a) Glutamate released by japanese encephalitis virus-infected microglia involves tnf-alpha signaling and contributes to neuronal death. Glia 60(3):487\u2013501. https:\/\/doi.org\/10.1002\/glia.22282","journal-title":"Glia"},{"issue":"4","key":"1598_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002655","volume":"8","author":"S Chen","year":"2012","unstructured":"Chen S, Liu R, Wu M et al (2012b) Clec5a regulates japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog 8(4):e1002655. https:\/\/doi.org\/10.1371\/journal.ppat.1002655","journal-title":"PLoS Pathog"},{"issue":"2","key":"1598_CR29","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1128\/JVI.02738-13","volume":"88","author":"C Chen","year":"2014","unstructured":"Chen C, Ou Y, Li J et al (2014) Infection of pericytes in vitro by japanese encephalitis virus disrupts the integrity of the endothelial barrier. J Virol 88(2):1150\u20131161. https:\/\/doi.org\/10.1128\/JVI.02738-13","journal-title":"J Virol"},{"issue":"1","key":"1598_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1280-8","volume":"15","author":"Z Chen","year":"2018","unstructured":"Chen Z, Wang X, Ashraf U et al (2018) Activation of neuronal N-methyl-D-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage. J Neuroinflammation 15(1):238. https:\/\/doi.org\/10.1186\/s12974-018-1280-8","journal-title":"J Neuroinflammation"},{"issue":"6","key":"1598_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101957","volume":"298","author":"H Chen","year":"2022","unstructured":"Chen H, Lin C, Anand A et al (2022a) Development of antiviral carbon quantum dots that target the japanese encephalitis virus envelope protein. J Biol Chem 298(6):101957. https:\/\/doi.org\/10.1016\/j.jbc.2022.101957","journal-title":"J Biol Chem"},{"issue":"3","key":"1598_CR32","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02583-21","volume":"10","author":"Z Chen","year":"2022","unstructured":"Chen Z, Zhao Z, Liu Y et al (2022b) Nucleotide-binding oligomerization domain 1 (nod1) positively regulates neuroinflammation during japanese encephalitis virus infection. Microbiol Spectr 10(3):e258321. https:\/\/doi.org\/10.1128\/spectrum.02583-21","journal-title":"Microbiol Spectr"},{"key":"1598_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1165378","volume-title":"Circular rna network plays a potential antiviral role in the early stage of jev infection in mouse brain","author":"M Chen","year":"2024","unstructured":"Chen M, Kang L, Zhang T et al (2024) Circular rna network plays a potential antiviral role in the early stage of jev infection in mouse brain. Frontiers Media SA, Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2023.1165378"},{"issue":"Pt 1","key":"1598_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129731","volume":"262","author":"H Chen","year":"2024","unstructured":"Chen H, Zhang Y, Zhang W et al (2024b) Palmitoylation of hifitm1 inhibits jev infection and contributes to bbb stabilization. Int J Biol Macromol 262(Pt 1):129731. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.129731","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"1598_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03579-0","volume":"22","author":"HW Cho","year":"2025","unstructured":"Cho HW, Byeon HW, Park SO et al (2025) The gut microbiota limits systemic inflammation during neurotrophic viral CNS infection by priming tonic type I interferon signaling. J Neuroinflammation 22(1):259. https:\/\/doi.org\/10.1186\/s12974-025-03579-0","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03078-8","volume":"21","author":"JY Choi","year":"2024","unstructured":"Choi JY, Byeon HW, Park SO, Uyangaa E, Kim K, Eo SK (2024) Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1-polarization of macrophages at the extraneural tissues. J Neuroinflammation 21(1):115. https:\/\/doi.org\/10.1186\/s12974-024-03078-8","journal-title":"J Neuroinflammation"},{"key":"1598_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103293","volume":"66","author":"S Deleu","year":"2021","unstructured":"Deleu S, Machiels K, Raes J, Verbeke K, Vermeire S (2021) Short chain fatty acids and its producing organisms: an overlooked therapy for IBD? EBioMedicine 66:103293. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103293","journal-title":"EBioMedicine"},{"issue":"6","key":"1598_CR38","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s00705-017-3226-3","volume":"162","author":"M Deng","year":"2017","unstructured":"Deng M, Du G, Zhao J, Du X (2017) Mir-146a negatively regulates the induction of proinflammatory cytokines in response to Japanese encephalitis virus infection in microglial cells. Arch Virol 162(6):1495\u20131505. https:\/\/doi.org\/10.1007\/s00705-017-3226-3","journal-title":"Arch Virol"},{"key":"1598_CR39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.molimm.2022.05.119","volume":"148","author":"L Deng","year":"2022","unstructured":"Deng L, Wang W, Bian P et al (2022) Qki deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response. Mol Immunol 148:34\u201344. https:\/\/doi.org\/10.1016\/j.molimm.2022.05.119","journal-title":"Mol Immunol"},{"issue":"5","key":"1598_CR40","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00077-25","volume":"99","author":"H Dong","year":"2025","unstructured":"Dong H, Hao Y, Wang J, Chen D, Xu S, Ruan W (2025) Japanese encephalitis virus NS1 inhibits IFN-\u03b2 production by interacting with DDX3X. J Virol 99(5):e7725. https:\/\/doi.org\/10.1128\/jvi.00077-25","journal-title":"J Virol"},{"key":"1598_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103433","volume":"78","author":"CM Dustin","year":"2024","unstructured":"Dustin CM, Shiva SS, Vazquez A et al (2024) Nox2 in Alzheimer\u2019s and Parkinson\u2019s disease. Redox Biol 78:103433. https:\/\/doi.org\/10.1016\/j.redox.2024.103433","journal-title":"Redox Biol"},{"issue":"11","key":"1598_CR42","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.imbio.2009.12.003","volume":"215","author":"K Dutta","year":"2010","unstructured":"Dutta K, Mishra MK, Nazmi A, Kumawat KL, Basu A (2010) Minocycline differentially modulates macrophage mediated peripheral immune response following Japanese encephalitis virus infection. Immunobiology 215(11):884\u2013893. https:\/\/doi.org\/10.1016\/j.imbio.2009.12.003","journal-title":"Immunobiology"},{"key":"1598_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1580958","volume":"15","author":"I Fellay","year":"2025","unstructured":"Fellay I, Blanc P, Larionov A, Schlunke L, Filgueira L, Lannes N (2025) Japanese encephalitis virus-associated human microglia induce cell death of human microvascular endothelial cells in receptor-independent infection. Front Cell Infect Microbiol 15:1580958. https:\/\/doi.org\/10.3389\/fcimb.2025.1580958","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"1598_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081266","volume":"13","author":"Y Feng","year":"2023","unstructured":"Feng Y, Jia L, Ma W, Tian C, Du H (2023) Iron chelator deferoxamine alleviates progression of diabetic nephropathy by relieving inflammation and fibrosis in rats. Biomolecules 13(8):1266. https:\/\/doi.org\/10.3390\/biom13081266","journal-title":"Biomolecules"},{"issue":"12","key":"1598_CR45","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B et al (2014) Inactivation of the ferroptosis regulator gpx4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180\u20131191. https:\/\/doi.org\/10.1038\/ncb3064","journal-title":"Nat Cell Biol"},{"issue":"2","key":"1598_CR46","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0006-2952(74)90421-3","volume":"23","author":"HJ Gaertner","year":"1974","unstructured":"Gaertner HJ, Breyer U, Liomin G (1974) Metabolism of trifluoperazine, fluphenazine, prochlorperazine and perphenazine in rats: in vitro and urinary metabolites. Biochem Pharmacol 23(2):303\u2013311. https:\/\/doi.org\/10.1016\/0006-2952(74)90421-3","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"1598_CR47","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1038\/s41423-021-00757-x","volume":"18","author":"I Galea","year":"2021","unstructured":"Galea I (2021) The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol 18(11):2489\u20132501. https:\/\/doi.org\/10.1038\/s41423-021-00757-x","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"1598_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-025-02956-8","volume":"22","author":"Y Gao","year":"2025","unstructured":"Gao Y, Shi X, Li B et al (2025) Signaling pathway of DNA replication and toll-like receptors was inhibited in c6\/36 cells infected with Japanese encephalitis virus. Virol J 22(1):362. https:\/\/doi.org\/10.1186\/s12985-025-02956-8","journal-title":"Virol J"},{"key":"1598_CR49","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.actatropica.2018.08.017","volume":"187","author":"TA Garjito","year":"2018","unstructured":"Garjito TA, Widiarti AYM et al (2018) Japanese encephalitis in indonesia: an update on epidemiology and transmission ecology. Acta Trop 187:240\u2013247. https:\/\/doi.org\/10.1016\/j.actatropica.2018.08.017","journal-title":"Acta Trop"},{"key":"1598_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.742359","volume":"12","author":"Z Guo","year":"2021","unstructured":"Guo Z, Liu J, Chang J et al (2021) Gas6\/axl signaling modulates blood-brain barrier function following intravenous thrombolysis in acute ischemic stroke. Front Immunol 12:742359. https:\/\/doi.org\/10.3389\/fimmu.2021.742359","journal-title":"Front Immunol"},{"key":"1598_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.791376","volume":"13","author":"Z Guo","year":"2022","unstructured":"Guo Z, Lin J, Sun K et al (2022) Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the nrf2 pathway. Front Pharmacol 13:791376. https:\/\/doi.org\/10.3389\/fphar.2022.791376","journal-title":"Front Pharmacol"},{"issue":"9","key":"1598_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004319","volume":"10","author":"YW Han","year":"2014","unstructured":"Han YW, Choi JY, Uyangaa E et al (2014) Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways. PLoS Pathog 10(9):e1004319. https:\/\/doi.org\/10.1371\/journal.ppat.1004319","journal-title":"PLoS Pathog"},{"issue":"8","key":"1598_CR53","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.4049\/jimmunol.1900003","volume":"203","author":"B Hazra","year":"2019","unstructured":"Hazra B, Chakraborty S, Bhaskar M, Mukherjee S, Mahadevan A, Basu A (2019) Mir-301a regulates inflammatory response to Japanese encephalitis virus infection via suppression of nkrf activity. J Immunol 203(8):2222\u20132238. https:\/\/doi.org\/10.4049\/jimmunol.1900003","journal-title":"J Immunol"},{"key":"1598_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00271","volume":"7","author":"W He","year":"2017","unstructured":"He W, Zhao Z, Anees A et al (2017) P21-activated kinase 4 signaling promotes Japanese encephalitis virus-mediated inflammation in astrocytes. Front Cell Infect Microbiol 7:271. https:\/\/doi.org\/10.3389\/fcimb.2017.00271","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"1598_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008260","volume":"16","author":"JT Hsieh","year":"2020","unstructured":"Hsieh JT, St John AL (2020) Japanese encephalitis virus and its mechanisms of neuroinvasion. PLoS Pathog 16(4):e1008260. https:\/\/doi.org\/10.1371\/journal.ppat.1008260","journal-title":"PLoS Pathog"},{"issue":"1","key":"1598_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08641-z","volume":"10","author":"JT Hsieh","year":"2019","unstructured":"Hsieh JT, Rathore APS, Soundarajan G, St John AL (2019) Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. Nat Commun 10(1):706. https:\/\/doi.org\/10.1038\/s41467-019-08641-z","journal-title":"Nat Commun"},{"issue":"28","key":"1598_CR57","doi-asserted-by":"publisher","first-page":"6804","DOI":"10.1016\/j.biomaterials.2011.05.053","volume":"32","author":"H Huang","year":"2011","unstructured":"Huang H, Rajanbabu V, Pan C et al (2011) Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1\u20135. Biomaterials 32(28):6804\u20136814. https:\/\/doi.org\/10.1016\/j.biomaterials.2011.05.053","journal-title":"Biomaterials"},{"issue":"1","key":"1598_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000221","volume":"43","author":"J Huxham","year":"2021","unstructured":"Huxham J, Tabari\u00e8s S, Siegel PM (2021) Afadin (AF6) in cancer progression: a multidomain scaffold protein with complex and contradictory roles. BioEssays 43(1):e2000221. https:\/\/doi.org\/10.1002\/bies.202000221","journal-title":"BioEssays"},{"issue":"11","key":"1598_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113181","volume":"10","author":"M Jhan","year":"2021","unstructured":"Jhan M, Chen C, Shen T et al (2021) Polarization of type 1 macrophages is associated with the severity of viral encephalitis caused by Japanese encephalitis virus and dengue virus. Cells 10(11):3181. https:\/\/doi.org\/10.3390\/cells10113181","journal-title":"Cells"},{"issue":"1","key":"1598_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3","volume":"17","author":"H Kadry","year":"2020","unstructured":"Kadry H, Noorani B, Cucullo L (2020) A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS 17(1):69. https:\/\/doi.org\/10.1186\/s12987-020-00230-3","journal-title":"Fluids Barriers CNS"},{"issue":"7089","key":"1598_CR61","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature04734","volume":"441","author":"H Kato","year":"2006","unstructured":"Kato H, Takeuchi O, Sato S et al (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441(7089):101\u2013105. https:\/\/doi.org\/10.1038\/nature04734","journal-title":"Nature"},{"key":"1598_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0438-x","volume":"12","author":"SB Kim","year":"2015","unstructured":"Kim SB, Choi JY, Kim JH et al (2015) Amelioration of Japanese encephalitis by blockage of 4-1bb signaling is coupled to divergent enhancement of type I\/II IFN responses and Ly-6c(hi) monocyte differentiation. J Neuroinflammation 12:216. https:\/\/doi.org\/10.1186\/s12974-015-0438-x","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0551-5","volume":"13","author":"SB Kim","year":"2016","unstructured":"Kim SB, Choi JY, Uyangaa E et al (2016) Blockage of indoleamine 2,3-dioxygenase regulates japanese encephalitis via enhancement of type i\/ii ifn innate and adaptive t-cell responses. J Neuroinflammation 13(1):79. https:\/\/doi.org\/10.1186\/s12974-016-0551-5","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33254-4","volume":"13","author":"K Kitidee","year":"2023","unstructured":"Kitidee K, Samutpong A, Pakpian N et al (2023) Antiviral effect of melatonin on japanese encephalitis virus infection involves inhibition of neuronal apoptosis and neuroinflammation in sh-sy5y cells. Sci Rep 13(1):6063. https:\/\/doi.org\/10.1038\/s41598-023-33254-4","journal-title":"Sci Rep"},{"issue":"3","key":"1598_CR65","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00702-005-0331-3","volume":"113","author":"J Kornhuber","year":"2006","unstructured":"Kornhuber J, Weigmann H, R\u00f6hrich J et al (2006) Region specific distribution of levomepromazine in the human brain. J Neural Transm 113(3):387\u2013397. https:\/\/doi.org\/10.1007\/s00702-005-0331-3","journal-title":"J Neural Transm"},{"key":"1598_CR66","doi-asserted-by":"publisher","unstructured":"Kumar S, Maurya VK, Kabir R et al (2020a) Antiviral activity of belladonna during japanese encephalitis virus infection via inhibition of microglia activation and inflammation leading to neuronal cell survival. ACS Chem Neurosci 11(21):3683\u20133696. https:\/\/doi.org\/10.1021\/acschemneuro.0c00603","DOI":"10.1021\/acschemneuro.0c00603"},{"key":"1598_CR67","doi-asserted-by":"publisher","unstructured":"Kumar N, Sharma S, Kumar R et al (2020b) Host-directed antiviral therapy. Clin Microbiol Rev 33(3):e119\u2013e168. https:\/\/doi.org\/10.1128\/CMR.00168-19","DOI":"10.1128\/CMR.00168-19"},{"key":"1598_CR68","doi-asserted-by":"publisher","unstructured":"Kumar S, Verma A, Yadav P et al (2022) Molecular pathogenesis of japanese encephalitis and possible therapeutic strategies. Arch Virol 167(9):1739\u20131762. https:\/\/doi.org\/10.1007\/s00705-022-05481-z","DOI":"10.1007\/s00705-022-05481-z"},{"issue":"1\u20132","key":"1598_CR69","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cellimm.2013.09.005","volume":"285","author":"K Kundu","year":"2013","unstructured":"Kundu K, Dutta K, Nazmi A, Basu A (2013) Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (socs) in macrophages: implications for the hosts\u2019 innate immune response. Cell Immunol 285(1\u20132):100\u2013110. https:\/\/doi.org\/10.1016\/j.cellimm.2013.09.005","journal-title":"Cell Immunol"},{"issue":"1","key":"1598_CR70","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh S (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9(1):42. https:\/\/doi.org\/10.1186\/s40035-020-00221-2","journal-title":"Transl Neurodegener"},{"issue":"2","key":"1598_CR71","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1471-4159.2012.07889.x","volume":"123","author":"C Lai","year":"2012","unstructured":"Lai C, Ou Y, Chang C et al (2012) Endothelial japanese encephalitis virus infection enhances migration and adhesion of leukocytes to brain microvascular endothelia via mek-dependent expression of icam1 and the cinc and rantes chemokines. J Neurochem 123(2):250\u2013261. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07889.x","journal-title":"J Neurochem"},{"key":"1598_CR72","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","volume":"35","author":"UH Langen","year":"2019","unstructured":"Langen UH, Ayloo S, Gu C (2019) Development and cell biology of the blood-brain barrier. Annu Rev Cell Dev Biol 35:591\u2013613. https:\/\/doi.org\/10.1146\/annurev-cellbio-100617-062608","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"1598_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0675-3","volume":"14","author":"N Lannes","year":"2017","unstructured":"Lannes N, Neuhaus V, Scolari B et al (2017) Interactions of human microglia cells with japanese encephalitis virus. Virol J 14(1):8. https:\/\/doi.org\/10.1186\/s12985-016-0675-3","journal-title":"Virol J"},{"key":"1598_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41302-1","author":"N Lannes","year":"2019","unstructured":"Lannes N, Garcia-Nicol\u00e0s O, D\u00e9moulins T, Summerfield A, Filgueira L (2019) Cx3cr1-cx3cl1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-019-41302-1","journal-title":"Sci Rep"},{"issue":"10","key":"1598_CR75","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.1128\/JVI.00143-15","volume":"89","author":"F Li","year":"2015","unstructured":"Li F, Wang Y, Yu L et al (2015) Viral infection of the central nervous system and neuroinflammation precede blood-brain barrier disruption during Japanese encephalitis virus infection. J Virol 89(10):5602\u20135614. https:\/\/doi.org\/10.1128\/JVI.00143-15","journal-title":"J Virol"},{"issue":"1","key":"1598_CR76","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-020-06822-5","volume":"21","author":"Y Li","year":"2020","unstructured":"Li Y, Ashraf U, Chen Z et al (2020) Genome-wide profiling of host-encoded circular rnas highlights their potential role during the Japanese encephalitis virus-induced neuroinflammatory response. BMC Genomics 21(1):409. https:\/\/doi.org\/10.1186\/s12864-020-06822-5","journal-title":"BMC Genomics"},{"issue":"3","key":"1598_CR77","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.01661-21","volume":"9","author":"Q Li","year":"2021","unstructured":"Li Q, Zhou D, Jia F et al (2021) Japanese encephalitis virus ns1\u2019 protein interacts with host cdk1 protein to regulate antiviral response. Microbiol Spectr 9(3):e166121. https:\/\/doi.org\/10.1128\/Spectrum.01661-21","journal-title":"Microbiol Spectr"},{"key":"1598_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2021.104290","volume":"127","author":"C Li","year":"2022","unstructured":"Li C, Zhou Y, Chen X et al (2022) Porcine trim35 positively regulate traf3-mediated ifn-\u03b2 production and inhibit Japanese encephalitis virus replication. Dev Comp Immunol 127:104290. https:\/\/doi.org\/10.1016\/j.dci.2021.104290","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"1598_CR79","first-page":"409","volume":"53","author":"H Li","year":"2023","unstructured":"Li H, Ni J, Zhang L, Liu J (2023a) Gas6 exerts neuroprotective effects via restoring the blood-brain barrier in mice with sepsis-associated encephalopathy. Ann Clin Lab Sci 53(3):409\u2013417","journal-title":"Ann Clin Lab Sci"},{"key":"1598_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2023.109887","volume":"287","author":"X Li","year":"2023","unstructured":"Li X, Chen J, Ou Y et al (2023b) M(6)a modification associated with ythdf1 is involved in Japanese encephalitis virus infection. Vet Microbiol 287:109887. https:\/\/doi.org\/10.1016\/j.vetmic.2023.109887","journal-title":"Vet Microbiol"},{"issue":"1","key":"1598_CR81","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01340-3","volume":"15","author":"M Li","year":"2025","unstructured":"Li M, Yuan H, Yang X, Lei Y, Lian J (2025a) Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis. Cell Biosci 15(1):6. https:\/\/doi.org\/10.1186\/s13578-024-01340-3","journal-title":"Cell Biosci"},{"issue":"4","key":"1598_CR82","doi-asserted-by":"publisher","first-page":"20825","DOI":"10.1128\/mbio.00208-25","volume":"16","author":"C Li","year":"2025","unstructured":"Li C, Tang C, Liu X et al (2025) E3 ubiquitin ligase march5 positively regulates japanese encephalitis virus infection by catalyzing the k27-linked polyubiquitination of viral e protein and inhibiting mavs-mediated type i interferon production. mBio 16(4):20825. https:\/\/doi.org\/10.1128\/mbio.00208-25","journal-title":"mBio"},{"issue":"3","key":"1598_CR83","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","volume":"135","author":"S Liebner","year":"2018","unstructured":"Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G (2018) Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol 135(3):311\u2013336. https:\/\/doi.org\/10.1007\/s00401-018-1815-1","journal-title":"Acta Neuropathol"},{"key":"1598_CR84","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6833867","volume":"2022","author":"D Lin","year":"2022","unstructured":"Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z (2022) Targeting ferroptosis attenuates inflammation, fibrosis, and mast cell activation in chronic prostatitis. J Immunol Res 2022:6833867. https:\/\/doi.org\/10.1155\/2022\/6833867","journal-title":"J Immunol Res"},{"issue":"6","key":"1598_CR85","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/13550280802339643","volume":"14","author":"T Liu","year":"2008","unstructured":"Liu T, Liang L, Wang C, Liu H, Chen W (2008) The blood-brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system. J Neurovirol 14(6):514\u2013521. https:\/\/doi.org\/10.1080\/13550280802339643","journal-title":"J Neurovirol"},{"key":"1598_CR86","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cyto.2018.04.022","volume":"110","author":"K Liu","year":"2018","unstructured":"Liu K, Xiao C, Wang F et al (2018) Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model. Cytokine 110:70\u201377. https:\/\/doi.org\/10.1016\/j.cyto.2018.04.022","journal-title":"Cytokine"},{"key":"1598_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2023.104902","volume":"148","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang L, Chen X et al (2023) Functional characterization of porcine nucleophosmin (npm1) gene in promoting the replication of japanese encephalitis virus and induction of inflammatory cytokines. Dev Comp Immunol 148:104902. https:\/\/doi.org\/10.1016\/j.dci.2023.104902","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"1598_CR88","doi-asserted-by":"publisher","first-page":"370","DOI":"10.7416\/ai.2024.2616","volume":"36","author":"PL Lopalco","year":"2024","unstructured":"Lopalco PL, Biasio LR (2024) Japanese encephalitis can be devastating. Ann Ig 36(3):370\u2013375. https:\/\/doi.org\/10.7416\/ai.2024.2616","journal-title":"Ann Ig"},{"issue":"11","key":"1598_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006693","volume":"13","author":"W Luo","year":"2017","unstructured":"Luo W, Li S, Li C et al (2017) Irhom2 is essential for innate immunity to rna virus by antagonizing er- and mitochondria-associated degradation of visa. PLoS Pathog 13(11):e1006693. https:\/\/doi.org\/10.1371\/journal.ppat.1006693","journal-title":"PLoS Pathog"},{"issue":"1","key":"1598_CR90","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02472-1","volume":"21","author":"C Luo","year":"2024","unstructured":"Luo C, Li M, Bian P et al (2024) The protective role of mertk in jev-induced\u00a0encephalitis by maintaining the integrity of blood-brain barrier. Virol J 21(1):217. https:\/\/doi.org\/10.1186\/s12985-024-02472-1","journal-title":"Virol J"},{"issue":"13","key":"1598_CR91","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1161\/CIRCULATIONAHA.118.034961","volume":"139","author":"Z Ma","year":"2019","unstructured":"Ma Z, Yu Y, Badea CT et al (2019) Vascular endothelial growth factor receptor 3 regulates endothelial function through \u03b2-arrestin 1. Circulation 139(13):1629\u20131642. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.034961","journal-title":"Circulation"},{"key":"1598_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2025.110779","volume":"311","author":"X Ma","year":"2025","unstructured":"Ma X, Ju L, Zheng J, Li Z, Gao L (2025) Japanese encephalitis virus infection modulates gut microbiota of immunocompetent mice. Vet Microbiol 311:110779. https:\/\/doi.org\/10.1016\/j.vetmic.2025.110779","journal-title":"Vet Microbiol"},{"issue":"7","key":"1598_CR93","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01321-24","volume":"15","author":"A Majumdar","year":"2024","unstructured":"Majumdar A, Siva Venkatesh IP, Swarup V, Basu A (2024) Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammation in microglial cells via mir-200a-3p\/zbtb20\/ik\u03b2\u03b1 axis. Mbio 15(7):e132124. https:\/\/doi.org\/10.1128\/mbio.01321-24","journal-title":"Mbio"},{"key":"1598_CR94","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-24","volume":"11","author":"GD Manocha","year":"2014","unstructured":"Manocha GD, Mishra R, Sharma N, Kumawat KL, Basu A, Singh SK (2014) Regulatory role of trim21 in the type-i interferon pathway in japanese encephalitis virus-infected human microglial cells. J Neuroinflammation 11:24. https:\/\/doi.org\/10.1186\/1742-2094-11-24","journal-title":"J Neuroinflammation"},{"issue":"3","key":"1598_CR95","first-page":"307","volume":"71","author":"A Mathur","year":"1990","unstructured":"Mathur A, Bharadwaj M, Chaturvedi UC (1990) Alterations in iron levels in Japanese encephalitis virus infection. J Exp Pathol (Oxford) 71(3):307\u2013312","journal-title":"J Exp Pathol (Oxford)"},{"issue":"5","key":"1598_CR96","first-page":"603","volume":"73","author":"A Mathur","year":"1992","unstructured":"Mathur A, Khanna N, Chaturvedi UC (1992) Breakdown of blood-brain barrier by virus-induced cytokine during Japanese encephalitis virus infection. Int J Exp Pathol 73(5):603\u2013611","journal-title":"Int J Exp Pathol"},{"issue":"5","key":"1598_CR97","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/ajhp\/36.5.633","volume":"36","author":"JL McGee","year":"1979","unstructured":"McGee JL, Alexander MR (1979) Phenothiazine analgesia\u2013fact or fantasy? Am J Hosp Pharm 36(5):633\u2013640. https:\/\/doi.org\/10.1093\/ajhp\/36.5.633","journal-title":"Am J Hosp Pharm"},{"issue":"12","key":"1598_CR98","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1038\/nm.3974","volume":"21","author":"JJ Miner","year":"2015","unstructured":"Miner JJ, Daniels BP, Shrestha B et al (2015) The tam receptor mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nat Med 21(12):1464\u20131472. https:\/\/doi.org\/10.1038\/nm.3974","journal-title":"Nat Med"},{"issue":"12","key":"1598_CR99","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.cellbi.2008.08.020","volume":"32","author":"MK Mishra","year":"2008","unstructured":"Mishra MK, Kumawat KL, Basu A (2008) Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines. Cell Biol Int 32(12):1506\u20131513. https:\/\/doi.org\/10.1016\/j.cellbi.2008.08.020","journal-title":"Cell Biol Int"},{"key":"1598_CR100","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.virol.2022.06.012","volume":"573","author":"R Mishra","year":"2022","unstructured":"Mishra R, Kumawat KL, Basu A, Banerjea AC (2022) Japanese encephalitis virus infection increases usp42 to stabilize trim21 and oas1 for neuroinflammatory and anti-viral response in human microglia. Virology 573:131\u2013140. https:\/\/doi.org\/10.1016\/j.virol.2022.06.012","journal-title":"Virology"},{"key":"1598_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156328","volume":"170","author":"S Mohapatra","year":"2023","unstructured":"Mohapatra S, Chakraborty T, Basu A (2023a) Japanese encephalitis virus infection in astrocytes modulate microglial function: correlation with inflammation and oxidative stress. Cytokine 170:156328. https:\/\/doi.org\/10.1016\/j.cyto.2023.156328","journal-title":"Cytokine"},{"key":"1598_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156383","volume":"172","author":"S Mohapatra","year":"2023","unstructured":"Mohapatra S, Tripathi S, Sharma V, Basu A (2023b) Regulation of microglia-mediated inflammation by host lncrna gm20559 upon flaviviral infection. Cytokine 172:156383. https:\/\/doi.org\/10.1016\/j.cyto.2023.156383","journal-title":"Cytokine"},{"issue":"1","key":"1598_CR103","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-023-00832-1","volume":"24","author":"J Moon","year":"2023","unstructured":"Moon J, Hong J, Seol J, Park B, Eo SK, Park S (2023) Melatonin inhibits japanese encephalitis virus replication and neurotoxicity via calcineurin-autophagy pathways. BMC Neurosci 24(1):59. https:\/\/doi.org\/10.1186\/s12868-023-00832-1","journal-title":"BMC Neurosci"},{"issue":"6","key":"1598_CR104","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/00480169.2023.2248054","volume":"71","author":"RS Morris","year":"2023","unstructured":"Morris RS, Bingham PC (2023) Japanese encephalitis virus: epidemiology and risk-based surveillance approaches for New Zealand. N Z Vet J 71(6):283\u2013294. https:\/\/doi.org\/10.1080\/00480169.2023.2248054","journal-title":"N Z Vet J"},{"issue":"2","key":"1598_CR105","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/cbin.10354","volume":"39","author":"S Mukherjee","year":"2014","unstructured":"Mukherjee S, Ghosh S, Nazmi A, Basu A (2014) Rig-i knockdown impedes neurogenesis in a murine model of japanese encephalitis. Cell Biol Int 39(2):224\u2013229. https:\/\/doi.org\/10.1002\/cbin.10354","journal-title":"Cell Biol Int"},{"issue":"4","key":"1598_CR106","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/jnc.14645","volume":"149","author":"S Mukherjee","year":"2019","unstructured":"Mukherjee S, Akbar I, Kumari B, Vrati S, Basu A, Banerjee A (2019) Japanese encephalitis virus-induced let-7a\/b interacted with the notch-tlr7 pathway in microglia and facilitated neuronal death via caspase activation. J Neurochem 149(4):518\u2013534. https:\/\/doi.org\/10.1111\/jnc.14645","journal-title":"J Neurochem"},{"issue":"12","key":"1598_CR107","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10121534","volume":"10","author":"P Mulvey","year":"2021","unstructured":"Mulvey P, Duong V, Boyer S et al (2021) The ecology and evolution of japanese encephalitis virus. Pathogens 10(12):1534. https:\/\/doi.org\/10.3390\/pathogens10121534","journal-title":"Pathogens"},{"issue":"6","key":"1598_CR108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021761","volume":"6","author":"A Nazmi","year":"2011","unstructured":"Nazmi A, Dutta K, Basu A (2011a) Rig-i mediates innate immune response in mouse neurons following japanese encephalitis virus infection. PLoS ONE 6(6):e21761. https:\/\/doi.org\/10.1371\/journal.pone.0021761","journal-title":"PLoS ONE"},{"issue":"3","key":"1598_CR109","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s11481-011-9271-x","volume":"6","author":"A Nazmi","year":"2011","unstructured":"Nazmi A, Dutta K, Das S, Basu A (2011b) Japanese encephalitis virus-infected macrophages induce neuronal death. J Neuroimmune Pharmacol 6(3):420\u2013433. https:\/\/doi.org\/10.1007\/s11481-011-9271-x","journal-title":"J Neuroimmune Pharmacol"},{"key":"1598_CR110","doi-asserted-by":"publisher","DOI":"10.1038\/srep00347","volume":"2","author":"A Nazmi","year":"2012","unstructured":"Nazmi A, Mukhopadhyay R, Dutta K, Basu A (2012) Sting mediates neuronal innate immune response following japanese encephalitis virus infection. Sci Rep 2:347. https:\/\/doi.org\/10.1038\/srep00347","journal-title":"Sci Rep"},{"key":"1598_CR111","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.nbd.2014.05.036","volume":"69","author":"A Nazmi","year":"2014","unstructured":"Nazmi A, Mukherjee S, Kundu K et al (2014) Tlr7 is a key regulator of innate immunity against japanese encephalitis virus infection. Neurobiol Dis 69:235\u2013247. https:\/\/doi.org\/10.1016\/j.nbd.2014.05.036","journal-title":"Neurobiol Dis"},{"issue":"9","key":"1598_CR112","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092534","volume":"12","author":"P Ninfali","year":"2020","unstructured":"Ninfali P, Antonelli A, Magnani M, Scarpa ES (2020) Antiviral properties of flavonoids and delivery strategies. Nutrients 12(9):2534. https:\/\/doi.org\/10.3390\/nu12092534","journal-title":"Nutrients"},{"issue":"43","key":"1598_CR113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2515006122","volume":"122","author":"Y Orba","year":"2025","unstructured":"Orba Y, Kashima Y, Tabata K et al (2025) Spatial gene expression analysis reveals pathological niches in japanese encephalitis virus neuroinvasion. Proc Natl Acad Sci U S A 122(43):e1779961174. https:\/\/doi.org\/10.1073\/pnas.2515006122","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"1598_CR114","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/jat.4397","volume":"43","author":"M Otr\u0119ba","year":"2023","unstructured":"Otr\u0119ba M, Stojko J, Rzepecka-Stojko A (2023) The role of phenothiazine derivatives in autophagy regulation: a systematic review. J Appl Toxicol 43(4):474\u2013489. https:\/\/doi.org\/10.1002\/jat.4397","journal-title":"J Appl Toxicol"},{"key":"1598_CR115","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-97","volume":"11","author":"S Pareek","year":"2014","unstructured":"Pareek S, Roy S, Kumari B, Jain P, Banerjee A, Vrati S (2014) Mir-155 induction in microglial cells suppresses japanese encephalitis virus replication and negatively modulates innate immune responses. J Neuroinflammation 11:97. https:\/\/doi.org\/10.1186\/1742-2094-11-97","journal-title":"J Neuroinflammation"},{"issue":"4","key":"1598_CR116","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.142","volume":"5","author":"Y Park","year":"2014","unstructured":"Park Y, Nguyen OTK, Kang H, Cho H (2014) March5-mediated quality control on acetylated mfn1 facilitates mitochondrial homeostasis and cell survival. Cell Death Dis 5(4):e1172. https:\/\/doi.org\/10.1038\/cddis.2014.142","journal-title":"Cell Death Dis"},{"key":"1598_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109520","volume":"67","author":"Y Park","year":"2020","unstructured":"Park Y, Oanh NTK, Heo J et al (2020) Dual targeting of rig-i and mavs by march5 mitochondria ubiquitin ligase in innate immunity. Cell Signal 67:109520. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109520","journal-title":"Cell Signal"},{"issue":"1","key":"1598_CR118","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.clpt.2005.10.005","volume":"79","author":"A Periclou","year":"2006","unstructured":"Periclou A, Ventura D, Rao N, Abramowitz W (2006) Pharmacokinetic study of memantine in healthy and renally impaired subjects. Clin Pharmacol Ther 79(1):134\u2013143. https:\/\/doi.org\/10.1016\/j.clpt.2005.10.005","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1598_CR119","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1161\/ATVBAHA.114.303352","volume":"34","author":"SA Popson","year":"2014","unstructured":"Popson SA, Ziegler ME, Chen X et al (2014) Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterioscler Thromb Vasc Biol 34(5):1011\u20131019. https:\/\/doi.org\/10.1161\/ATVBAHA.114.303352","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"1598_CR120","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s44321-023-00014-w","volume":"16","author":"SK Prajapat","year":"2024","unstructured":"Prajapat SK, Mishra L, Khera S et al (2024) Methotrimeprazine is a neuroprotective antiviral in jev infection via adaptive er stress and autophagy. EMBO Mol Med 16(1):185\u2013217. https:\/\/doi.org\/10.1038\/s44321-023-00014-w","journal-title":"EMBO Mol Med"},{"issue":"6","key":"1598_CR121","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.celrep.2019.01.036","volume":"26","author":"H Puerta-Guardo","year":"2019","unstructured":"Puerta-Guardo H, Glasner DR, Espinosa DA et al (2019) Flavivirus ns1 triggers tissue-specific vascular endothelial dysfunction reflecting disease tropism. Cell Rep 26(6):1598\u20131613. https:\/\/doi.org\/10.1016\/j.celrep.2019.01.036","journal-title":"Cell Rep"},{"issue":"5","key":"1598_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112489","volume":"42","author":"L Qi","year":"2023","unstructured":"Qi L, Li X, Zhang F et al (2023) Vegfr-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection. Cell Rep 42(5):112489. https:\/\/doi.org\/10.1016\/j.celrep.2023.112489","journal-title":"Cell Rep"},{"key":"1598_CR123","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153696","volume":"91","author":"X Qian","year":"2021","unstructured":"Qian X, Zhang X, Sun L et al (2021) Corosolic acid and its structural analogs: a systematic review of their biological activities and underlying mechanism of action. Phytomedicine 91:153696. https:\/\/doi.org\/10.1016\/j.phymed.2021.153696","journal-title":"Phytomedicine"},{"issue":"1","key":"1598_CR124","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s13365-023-01190-8","volume":"30","author":"A Rani","year":"2024","unstructured":"Rani A, Erg\u00fcn S, Karnati S, Jha HC (2024) Understanding the link between neurotropic viruses, bbb permeability, and ms pathogenesis. J Neurovirol 30(1):22\u201338. https:\/\/doi.org\/10.1007\/s13365-023-01190-8","journal-title":"J Neurovirol"},{"issue":"11","key":"1598_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2020.194639","volume":"1863","author":"M Rastogi","year":"2020","unstructured":"Rastogi M, Singh SK (2020) Japanese encephalitis virus exploits microrna-155 to suppress the non-canonical nf-\u03bab pathway in human microglial cells. Biochim Et Biophys Acta (BBA) - Gene Regul Mech 1863(11):194639. https:\/\/doi.org\/10.1016\/j.bbagrm.2020.194639","journal-title":"Biochim Et Biophys Acta (BBA) - Gene Regul Mech"},{"key":"1598_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121949","volume":"293","author":"FU Rehman","year":"2023","unstructured":"Rehman FU, Liu Y, Zheng M, Shi B (2023) Exosomes based strategies for brain drug delivery. Biomaterials 293:121949. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121949","journal-title":"Biomaterials"},{"key":"1598_CR127","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/0470058005.ch10","volume":"277","author":"V Satchidanandam","year":"2006","unstructured":"Satchidanandam V, Uchil PD, Kumar P (2006) Organization of flaviviral replicase proteins in virus-induced membranes: a role for ns1\u2019 in japanese encephalitis virus rna synthesis. Novartis Found Symp 277:136\u2013253. https:\/\/doi.org\/10.1002\/0470058005.ch10","journal-title":"Novartis Found Symp"},{"issue":"8","key":"1598_CR128","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s11011-023-01279-3","volume":"38","author":"A Satheesan","year":"2023","unstructured":"Satheesan A, Sharma S, Basu A (2023) Sodium butyrate induced neural stem\/progenitor cell death in an experimental model of japanese encephalitis. Metab Brain Dis 38(8):2831\u20132847. https:\/\/doi.org\/10.1007\/s11011-023-01279-3","journal-title":"Metab Brain Dis"},{"issue":"2","key":"1598_CR129","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1080\/02648725.2023.2166258","volume":"39","author":"SK Saxena","year":"2023","unstructured":"Saxena SK, Kumar S, Maurya VK et al (2023) Antiviral and anti-inflammatory activity of novel belladonna formulation against japanese encephalitis virus via inhibition of p65 nuclear translocation and tnf-\u03b1 mediated nf-kb signaling. Biotechnol Genet Eng Rev 39(2):937\u2013959. https:\/\/doi.org\/10.1080\/02648725.2023.2166258","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"4","key":"1598_CR130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035427","volume":"7","author":"N Sehgal","year":"2012","unstructured":"Sehgal N, Kumawat KL, Basu A, Ravindranath V (2012) Fenofibrate reduces mortality and precludes neurological deficits in survivors in murine model of japanese encephalitis viral infection. PLoS ONE 7(4):e35427. https:\/\/doi.org\/10.1371\/journal.pone.0035427","journal-title":"PLoS ONE"},{"key":"1598_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100994","volume":"81","author":"KB Sharma","year":"2021","unstructured":"Sharma KB, Vrati S, Kalia M (2021a) Pathobiology of Japanese encephalitis virus infection. Mol Aspects Med 81:100994. https:\/\/doi.org\/10.1016\/j.mam.2021.100994","journal-title":"Mol Aspects Med"},{"issue":"9","key":"1598_CR132","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1099\/jgv.0.001657","volume":"102","author":"KB Sharma","year":"2021","unstructured":"Sharma KB, Chhabra S, Aggarwal S et al (2021b) Proteomic landscape of Japanese encephalitis virus-infected fibroblasts. J Gen Virol 102(9):10\u20131099. https:\/\/doi.org\/10.1099\/jgv.0.001657","journal-title":"J Gen Virol"},{"key":"1598_CR133","doi-asserted-by":"publisher","DOI":"10.3390\/biom15070992","author":"X Shi","year":"2025","unstructured":"Shi X, Chen S, Liu M et al (2025) The unconventional role of ABHD17A in increasing the S-palmitoylation and antiviral activity of IFITM1 by downregulating ABHD16A. Biomolecules. https:\/\/doi.org\/10.3390\/biom15070992","journal-title":"Biomolecules"},{"issue":"1","key":"1598_CR134","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-01966-8","volume":"20","author":"M Shukla","year":"2023","unstructured":"Shukla M, Garg A, Dhole TN, Chaturvedi R (2023) Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephalitis infected bv2 and neuro 2a cell lines associated with worst outcome. Virol J 20(1):16. https:\/\/doi.org\/10.1186\/s12985-023-01966-8","journal-title":"Virol J"},{"key":"1598_CR135","doi-asserted-by":"publisher","unstructured":"Singh G, Kumar A (2023) Japanese encephalitis virus infection causes an imbalance in the activation of mitochondrial fusion\/fission genes and triggers the activation of nox2-mediated oxidative stress and neuronal cell death. Neurochem Res 48(7):2196\u20132205. https:\/\/doi.org\/10.1007\/s11064-023-03898-9","DOI":"10.1007\/s11064-023-03898-9"},{"key":"1598_CR136","doi-asserted-by":"publisher","unstructured":"Singh A, Ghosh R, Guchhait P (2023) Cxcr3 antagonist rescues er stress and reduces inflammation and JEV infection in mice brain. Cytokine 172:156380. https:\/\/doi.org\/10.1016\/j.cyto.2023.156380","DOI":"10.1016\/j.cyto.2023.156380"},{"issue":"1","key":"1598_CR137","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12035-023-03538-x","volume":"61","author":"G Singh","year":"2024","unstructured":"Singh G, Singh A, Mishra S, Singh D, Kumar A (2024) Intracellular iron accumulation induces inflammatory and oxidative status of the host after Japanese encephalitis viral infection. Mol Neurobiol 61(1):175\u2013187. https:\/\/doi.org\/10.1007\/s12035-023-03538-x","journal-title":"Mol Neurobiol"},{"issue":"1","key":"1598_CR138","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011459","volume":"18","author":"M Sistrom","year":"2024","unstructured":"Sistrom M, Andrews H, Edwards DL (2024) Comparative genomics of Japanese encephalitis virus shows low rates of recombination and a small subset of codon positions under episodic diversifying selection. PLoS Negl Trop Dis 18(1):e11459. https:\/\/doi.org\/10.1371\/journal.pntd.0011459","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"1598_CR139","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s11011-022-00991-w","volume":"37","author":"IP Siva Venkatesh","year":"2022","unstructured":"Siva Venkatesh IP, Bhaskar M, Basu A (2022) Japanese encephalitis viral infection modulates proinflammatory cyto\/chemokine profile in primary astrocyte and cell line of astrocytic origin. Metab Brain Dis 37(5):1487\u20131502. https:\/\/doi.org\/10.1007\/s11011-022-00991-w","journal-title":"Metab Brain Dis"},{"issue":"7702","key":"1598_CR140","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41586-018-0039-9","volume":"556","author":"X Song","year":"2018","unstructured":"Song X, Jensen M\u00d8, Jogini V et al (2018) Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature 556(7702):515\u2013519. https:\/\/doi.org\/10.1038\/s41586-018-0039-9","journal-title":"Nature"},{"issue":"10","key":"1598_CR141","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102252","volume":"14","author":"K Sun","year":"2022","unstructured":"Sun K, Zheng X, Jin H, Yu F, Zhao W (2022) Exosomes as cns drug delivery tools and their applications. Pharmaceutics 14(10):2252. https:\/\/doi.org\/10.3390\/pharmaceutics14102252","journal-title":"Pharmaceutics"},{"issue":"9","key":"1598_CR142","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116210","volume":"44","author":"T Suzuki","year":"2025","unstructured":"Suzuki T, Miyata Y, Haga S et al (2025) Selective tlr ligand stimulation enhances in vivo mosquito-borne flavivirus pathogenicity. Cell Rep 44(9):116210. https:\/\/doi.org\/10.1016\/j.celrep.2025.116210","journal-title":"Cell Rep"},{"issue":"9","key":"1598_CR143","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1128\/aac.00041-07","volume":"51","author":"V Swarup","year":"2007","unstructured":"Swarup V, Ghosh J, Ghosh S, Saxena A, Basu A (2007) Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of japanese encephalitis. Antimicrob Agents Chemother 51(9):3367\u20133370. https:\/\/doi.org\/10.1128\/aac.00041-07","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"1598_CR144","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/jac\/dkm503","volume":"61","author":"V Swarup","year":"2008","unstructured":"Swarup V, Ghosh J, Mishra MK, Basu A (2008) Novel strategy for treatment of japanese encephalitis using arctigenin, a plant lignan. J Antimicrob Chemother 61(3):679\u2013688. https:\/\/doi.org\/10.1093\/jac\/dkm503","journal-title":"J Antimicrob Chemother"},{"key":"1598_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108440","volume":"247","author":"D Swinkels","year":"2023","unstructured":"Swinkels D, Baes M (2023) The essential role of docosahexaenoic acid and its derivatives for retinal integrity. Pharmacol Ther 247:108440. https:\/\/doi.org\/10.1016\/j.pharmthera.2023.108440","journal-title":"Pharmacol Ther"},{"issue":"4","key":"1598_CR146","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2149\/tmh.2015-27","volume":"43","author":"Y Takamatsu","year":"2015","unstructured":"Takamatsu Y, Raekiansyah M, Morita K, Hayasaka D (2015) Ns1\u2019 protein expression in the jaoars982 strain of japanese encephalitis virus does not enhance virulence in mice. Trop Med Health 43(4):233\u2013237. https:\/\/doi.org\/10.2149\/tmh.2015-27","journal-title":"Trop Med Health"},{"issue":"2","key":"1598_CR147","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125. https:\/\/doi.org\/10.1038\/s41422-020-00441-1","journal-title":"Cell Res"},{"key":"1598_CR01","doi-asserted-by":"publisher","unstructured":"Tarigan R, Shimoda H, Doysabas KCC, Ken M, Iida A, Hondo E (2020) Role of pattern recognition receptors and interferon-beta in protecting bat cell lines from encephalomyocarditis virus and Japanese encephalitis virus infection. Biochem Biophys Res Commun 527(1):1\u20137. https:\/\/doi.org\/10.1016\/j.bbrc.2020.04.060","DOI":"10.1016\/j.bbrc.2020.04.060"},{"issue":"3","key":"1598_CR148","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/infdis\/142.3.394","volume":"142","author":"JL Taylor","year":"1980","unstructured":"Taylor JL, Schoenherr C, Grossberg SE (1980) Protection against japanese encephalitis virus in mice and hamsters by treatment with carboxymethylacridanone, a potent interferon inducer. J Infect Dis 142(3):394\u2013399. https:\/\/doi.org\/10.1093\/infdis\/142.3.394","journal-title":"J Infect Dis"},{"key":"1598_CR149","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/890586","volume":"2012","author":"T Thongtan","year":"2012","unstructured":"Thongtan T, Thepparit C, Smith DR (2012) The involvement of microglial cells in Japanese encephalitis infections. Clin Dev Immunol 2012:890586. https:\/\/doi.org\/10.1155\/2012\/890586","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"1598_CR150","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/jnc.12609","volume":"129","author":"MC Thounaojam","year":"2014","unstructured":"Thounaojam MC, Kaushik DK, Kundu K, Basu A (2014) Microrna-29b modulates japanese encephalitis virus-induced microglia activation by targeting tumor necrosis factor alpha-induced protein 3. J Neurochem 129(1):143\u2013154. https:\/\/doi.org\/10.1111\/jnc.12609","journal-title":"J Neurochem"},{"issue":"21","key":"1598_CR151","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00406-21","volume":"95","author":"A Tripathi","year":"2021","unstructured":"Tripathi A, Singh Rawat B, Addya S et al (2021) Lack of interferon (ifn) regulatory factor 8 associated with restricted ifn-\u03b3 response augmented japanese encephalitis virus replication in the mouse brain. J Virol 95(21):e40621. https:\/\/doi.org\/10.1128\/JVI.00406-21","journal-title":"J Virol"},{"issue":"12","key":"1598_CR152","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01183-23","volume":"97","author":"S Tripathi","year":"2023","unstructured":"Tripathi S, Sengar S, Shree B, Mohapatra S, Basu A, Sharma V (2023) An rbm10 and nf-\u03bab interacting host lncrna promotes jev replication and neuronal cell death. J Virol 97(12):e118323. https:\/\/doi.org\/10.1128\/jvi.01183-23","journal-title":"J Virol"},{"issue":"5","key":"1598_CR153","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00066-25","volume":"99","author":"S Tripathi","year":"2025","unstructured":"Tripathi S, Sengar S, Basu A, Sharma V (2025) Lncrna jinr1 regulates mir-216b-5p\/grp78 and mir-1-3p\/ddx5 axis to promote jev infection and cell death. J Virol 99(5):e6625. https:\/\/doi.org\/10.1128\/jvi.00066-25","journal-title":"J Virol"},{"issue":"9","key":"1598_CR154","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00796-24","volume":"98","author":"S Tu","year":"2024","unstructured":"Tu S, Zou J, Xiong C et al (2024) Zinc-finger cchc-type containing protein 8 promotes rna virus replication by suppressing the type-i interferon responses. J Virol 98(9):e79624. https:\/\/doi.org\/10.1128\/jvi.00796-24","journal-title":"J Virol"},{"issue":"5","key":"1598_CR155","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrneurol.2018.30","volume":"14","author":"L Turtle","year":"2018","unstructured":"Turtle L, Solomon T (2018) Japanese encephalitis \u2014 the prospects for new treatments. Nat Rev Neurol 14(5):298\u2013313. https:\/\/doi.org\/10.1038\/nrneurol.2018.30","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"1598_CR156","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1021\/acschemneuro.4c00028","volume":"15","author":"IPS Venkatesh","year":"2024","unstructured":"Venkatesh IPS, Majumdar A, Basu A (2024) Prophylactic administration of gut microbiome metabolites abrogated microglial activation and subsequent neuroinflammation in an experimental model of japanese encephalitis. ACS Chem Neurosci 15(8):1712\u20131727. https:\/\/doi.org\/10.1021\/acschemneuro.4c00028","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"1598_CR157","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35059-x","volume":"13","author":"A Verma","year":"2022","unstructured":"Verma A, Singh A, Singh MP et al (2022) Ezh2-h3k27me3 mediated krt14 upregulation promotes tnbc peritoneal metastasis. Nat Commun 13(1):7344. https:\/\/doi.org\/10.1038\/s41467-022-35059-x","journal-title":"Nat Commun"},{"key":"1598_CR158","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2147\/TCRM.S51168","volume":"11","author":"H Wang","year":"2015","unstructured":"Wang H, Liang G (2015) Epidemiology of japanese encephalitis: past, present, and future prospects. Ther Clin Risk Manag 11:435\u2013448. https:\/\/doi.org\/10.2147\/TCRM.S51168","journal-title":"Ther Clin Risk Manag"},{"issue":"21","key":"1598_CR159","doi-asserted-by":"publisher","first-page":"e1017","DOI":"10.1128\/JVI.01055-17","volume":"91","author":"S Wang","year":"2017","unstructured":"Wang S, Liu Y, Guo J et al (2017) Screening of FDA-approved drugs for inhibitors of Japanese encephalitis virus infection. J Virol 91(21):e1017\u2013e1055. https:\/\/doi.org\/10.1128\/JVI.01055-17","journal-title":"J Virol"},{"key":"1598_CR160","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.3389\/fimmu.2018.01148","volume":"9","author":"K Wang","year":"2018","unstructured":"Wang K, Wang H, Lou W et al (2018) Ip-10 promotes blood-brain barrier damage by inducing tumor necrosis factor alpha production in japanese encephalitis. Front Immunol 9:1148. https:\/\/doi.org\/10.3389\/fimmu.2018.01148","journal-title":"Front Immunol"},{"issue":"17","key":"1598_CR161","doi-asserted-by":"publisher","first-page":"e602","DOI":"10.1128\/JVI.00602-20","volume":"94","author":"Z Wang","year":"2020","unstructured":"Wang Z, Zhen Z, Fan D et al (2020) Axl deficiency promotes the neuroinvasion of Japanese encephalitis virus by enhancing IL-1\u03b1 production from pyroptotic macrophages. J Virol 94(17):e602\u2013e620. https:\/\/doi.org\/10.1128\/JVI.00602-20","journal-title":"J Virol"},{"issue":"4","key":"1598_CR162","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s12250-020-00342-y","volume":"36","author":"Z Wang","year":"2021","unstructured":"Wang Z, Zhen Z, Fan D, Wang P, An J (2021a) Axl alleviates neuroinflammation and delays japanese encephalitis progression in mice. Virol Sin 36(4):667\u2013677. https:\/\/doi.org\/10.1007\/s12250-020-00342-y","journal-title":"Virol Sin"},{"key":"1598_CR163","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105483","volume":"165","author":"M Wang","year":"2021","unstructured":"Wang M, Lin L, Lu J, Chen X (2021b) Pharmacological review of isobavachalcone, a naturally occurring chalcone. Pharmacol Res 165:105483. https:\/\/doi.org\/10.1016\/j.phrs.2021.105483","journal-title":"Pharmacol Res"},{"key":"1598_CR164","doi-asserted-by":"publisher","DOI":"10.3390\/v16050734","author":"J Wang","year":"2024","unstructured":"Wang J, Luo Y, Katiyar H, Liang C, Liu Q (2024) The antiviral activity of interferon-induced transmembrane proteins and virus evasion strategies. Viruses. https:\/\/doi.org\/10.3390\/v16050734","journal-title":"Viruses"},{"issue":"6","key":"1598_CR165","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.24272\/j.issn.2095-8137.2025.081","volume":"46","author":"X Wang","year":"2025","unstructured":"Wang X, Zhao Q, Liu H et al (2025) Vegfr-3 deficiency in astrocytes exacerbates japanese encephalitis virus-induced neuroinflammation in mouse brains. Zool Res 46(6):1317\u20131325. https:\/\/doi.org\/10.24272\/j.issn.2095-8137.2025.081","journal-title":"Zool Res"},{"key":"1598_CR166","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138826","volume":"289","author":"X Wang","year":"2025","unstructured":"Wang X, Kong N, Wang C et al (2025b) Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication. Int J Biol Macromol 289:138826. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.138826","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"1598_CR167","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.antiviral.2009.10.008","volume":"85","author":"SC Weaver","year":"2010","unstructured":"Weaver SC, Reisen WK (2010) Present and future arboviral threats. Antiviral Res 85(2):328\u2013345. https:\/\/doi.org\/10.1016\/j.antiviral.2009.10.008","journal-title":"Antiviral Res"},{"issue":"2","key":"1598_CR168","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/tvjl.1998.0289","volume":"157","author":"SC Weaver","year":"1999","unstructured":"Weaver SC, Powers AM, Brault AC, Barrett AD (1999) Molecular epidemiological studies of veterinary arboviral encephalitides. Vet J (Lond, Engl: 1997) 157(2):123\u2013138. https:\/\/doi.org\/10.1053\/tvjl.1998.0289","journal-title":"Vet J (Lond, Engl: 1997)"},{"issue":"2","key":"1598_CR169","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-075569","volume":"14","author":"NE Winkler","year":"2024","unstructured":"Winkler NE, Koirala A, Kaur G et al (2024) Seroprevalence of Japanese encephalitis virus-specific antibodies in Australia following novel epidemic spread: protocol for a national cross-sectional study. BMJ Open 14(2):e75569. https:\/\/doi.org\/10.1136\/bmjopen-2023-075569","journal-title":"BMJ Open"},{"issue":"2","key":"1598_CR170","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.bcp.2014.05.005","volume":"90","author":"J W\u00f3jcikowski","year":"2014","unstructured":"W\u00f3jcikowski J, Basi\u0144ska A, Daniel WA (2014) The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application. Biochem Pharmacol 90(2):188\u2013195. https:\/\/doi.org\/10.1016\/j.bcp.2014.05.005","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1598_CR171","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1128\/JVI.02085-14","volume":"89","author":"J Wu","year":"2015","unstructured":"Wu J, Lu G, Zhang B, Gong P (2015) Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation. J Virol 89(1):249\u2013261. https:\/\/doi.org\/10.1128\/JVI.02085-14","journal-title":"J Virol"},{"issue":"1","key":"1598_CR172","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03266-6","volume":"21","author":"X Xiang","year":"2024","unstructured":"Xiang X, Yu D, Li Z et al (2024) Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression. J Neuroinflammation 21(1):277. https:\/\/doi.org\/10.1186\/s12974-024-03266-6","journal-title":"J Neuroinflammation"},{"issue":"6","key":"1598_CR173","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1007\/s12250-021-00442-3","volume":"36","author":"S Xie","year":"2021","unstructured":"Xie S, Liang Z, Yang X et al (2021) Japanese encephalitis virus NS2B-3 protein complex promotes cell apoptosis and viral particle release by down-regulating the expression of axl. Virol Sin 36(6):1503\u20131519. https:\/\/doi.org\/10.1007\/s12250-021-00442-3","journal-title":"Virol Sin"},{"key":"1598_CR174","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122749","volume":"312","author":"A Xie","year":"2025","unstructured":"Xie A, Cheng G, Wu J et al (2025) Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer\u2019s disease. Biomaterials 312:122749. https:\/\/doi.org\/10.1016\/j.biomaterials.2024.122749","journal-title":"Biomaterials"},{"issue":"8","key":"1598_CR175","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1002\/ptr.7520","volume":"36","author":"N Xing","year":"2022","unstructured":"Xing N, Meng X, Wang S (2022) Isobavachalcone: a comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. Phytother Res 36(8):3120\u20133142. https:\/\/doi.org\/10.1002\/ptr.7520","journal-title":"Phytother Res"},{"issue":"1","key":"1598_CR176","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.70033","volume":"14","author":"J Xiong","year":"2025","unstructured":"Xiong J, Yang L, Nan X et al (2025) Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus. J Extracell Vesicles 14(1):e70033. https:\/\/doi.org\/10.1002\/jev2.70033","journal-title":"J Extracell Vesicles"},{"issue":"7","key":"1598_CR177","doi-asserted-by":"publisher","DOI":"10.3390\/life12070952","volume":"12","author":"P Yadav","year":"2022","unstructured":"Yadav P, El-Kafrawy SA, El-Day MM et al (2022) Discovery of small molecules from echinacea angustifolia targeting RNA-dependent RNA polymerase of Japanese encephalitis virus. Life 12(7):952. https:\/\/doi.org\/10.3390\/life12070952","journal-title":"Life"},{"issue":"9","key":"1598_CR178","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006648","volume":"13","author":"B Yan","year":"2017","unstructured":"Yan B, Zhou L, Hu M et al (2017) Pkacs attenuate innate antiviral response by phosphorylating Visa and priming it for March5-mediated degradation. PLoS Pathog 13(9):e1006648. https:\/\/doi.org\/10.1371\/journal.ppat.1006648","journal-title":"PLoS Pathog"},{"issue":"1","key":"1598_CR179","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12974-024-03071-1","volume":"21","author":"L Yang","year":"2024","unstructured":"Yang L, Xiong J, Liu Y et al (2024a) Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus. J Neuroinflammation 21(1):76. https:\/\/doi.org\/10.1186\/s12974-024-03071-1","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR180","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-024-04397-x","volume":"20","author":"Y Yang","year":"2024","unstructured":"Yang Y, Hu X, Wang S et al (2024b) Rosmarinic acid-mediated downregulation of Rig-I and p62 in microglia confers resistance to Japanese encephalitis virus-induced inflammation. BMC Vet Res 20(1):555. https:\/\/doi.org\/10.1186\/s12917-024-04397-x","journal-title":"BMC Vet Res"},{"key":"1598_CR181","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2025.110698","volume":"309","author":"Q Yang","year":"2025","unstructured":"Yang Q, Xie S, Zhao Y et al (2025) Transferrin receptor 1 is an entry factor for Japanese encephalitis virus. Vet Microbiol 309:110698. https:\/\/doi.org\/10.1016\/j.vetmic.2025.110698","journal-title":"Vet Microbiol"},{"issue":"1","key":"1598_CR182","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02275-w","volume":"21","author":"M Yao","year":"2024","unstructured":"Yao M, Cheng Z, Li X et al (2024) N6-methyladenosine modification positively regulate Japanese encephalitis virus replication. Virol J 21(1):23. https:\/\/doi.org\/10.1186\/s12985-023-02275-w","journal-title":"Virol J"},{"issue":"6","key":"1598_CR183","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/infdis\/jiu179","volume":"210","author":"J Ye","year":"2014","unstructured":"Ye J, Jiang R, Cui M et al (2014) Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. J Infect Dis 210(6):875\u2013889. https:\/\/doi.org\/10.1093\/infdis\/jiu179","journal-title":"J Infect Dis"},{"issue":"448","key":"1598_CR184","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf5132","volume":"9","author":"J Ye","year":"2016","unstructured":"Ye J, Zhang H, He W et al (2016) Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Sci Signal 9(448):ra98. https:\/\/doi.org\/10.1126\/scisignal.aaf5132","journal-title":"Sci Signal"},{"issue":"8","key":"1598_CR185","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1128\/JVI.00039-17","volume":"91","author":"J Ye","year":"2017","unstructured":"Ye J, Chen Z, Li Y et al (2017) Japanese encephalitis virus ns5 inhibits type i interferon (ifn) production by blocking the nuclear translocation of ifn regulatory factor 3 and nf-\u03bab. J Virol 91(8):e17\u2013e39. https:\/\/doi.org\/10.1128\/JVI.00039-17","journal-title":"J Virol"},{"key":"1598_CR186","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2024.110199","volume":"297","author":"Y Yin","year":"2024","unstructured":"Yin Y, Liu L, Jiang Y, Xing J, Qi W, Huang L (2024) Slc25a12 inhibits Japanese encephalitis virus replication by interacting with the ns1 and enhancing the type i interferon response. Vet Microbiol 297:110199. https:\/\/doi.org\/10.1016\/j.vetmic.2024.110199","journal-title":"Vet Microbiol"},{"key":"1598_CR187","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8910","volume":"6","author":"Y Yoo","year":"2015","unstructured":"Yoo Y, Park Y, Kim J et al (2015) The mitochondrial ubiquitin ligase march5 resolves mavs aggregates during antiviral signalling. Nat Commun 6:7910. https:\/\/doi.org\/10.1038\/ncomms8910","journal-title":"Nat Commun"},{"issue":"12","key":"1598_CR188","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/s41419-019-2175-z","volume":"10","author":"Y Yoo","year":"2019","unstructured":"Yoo Y, Park Y, Lee H et al (2019) Mitochondria ubiquitin ligase, march5 resolves hepatitis b virus x protein aggregates in the liver pathogenesis. Cell Death Dis 10(12):938. https:\/\/doi.org\/10.1038\/s41419-019-2175-z","journal-title":"Cell Death Dis"},{"issue":"1","key":"1598_CR189","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41392-022-00994-0","volume":"7","author":"Y You","year":"2022","unstructured":"You Y, Lai X, Pan Y et al (2022) Artificial intelligence in cancer target identification and drug discovery. Signal Transduct Target Ther 7(1):156. https:\/\/doi.org\/10.1038\/s41392-022-00994-0","journal-title":"Signal Transduct Target Ther"},{"key":"1598_CR190","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.virol.2018.10.015","volume":"527","author":"SP Yu","year":"2019","unstructured":"Yu SP, Ong KC, Perera D, Wong KT (2019) Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine cxcl11 and pattern recognition receptors rig-1 and mda5. Virology 527:107\u2013115. https:\/\/doi.org\/10.1016\/j.virol.2018.10.015","journal-title":"Virology"},{"issue":"1","key":"1598_CR191","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01841-8","volume":"22","author":"S Yue","year":"2023","unstructured":"Yue S, Liu H, Su H et al (2023) M6a-regulated tumor glycolysis: new advances in epigenetics and metabolism. Mol Cancer 22(1):137. https:\/\/doi.org\/10.1186\/s12943-023-01841-8","journal-title":"Mol Cancer"},{"issue":"6","key":"1598_CR192","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101977RR","volume":"36","author":"Z Zeng","year":"2022","unstructured":"Zeng Z, Huang H, Zhang J et al (2022) Hdm induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma. FASEB J 36(6):e22359. https:\/\/doi.org\/10.1096\/fj.202101977RR","journal-title":"FASEB J"},{"key":"1598_CR193","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2023.109849","volume":"284","author":"Q Zeng","year":"2023","unstructured":"Zeng Q, Liu J, Li Z et al (2023) Japanese encephalitis virus ns4b inhibits interferon beta production by targeting tlr3 and trif. Vet Microbiol 284:109849. https:\/\/doi.org\/10.1016\/j.vetmic.2023.109849","journal-title":"Vet Microbiol"},{"key":"1598_CR194","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.894356","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Chen H, Zhang H et al (2022) Egfr activation impairs antiviral activity of interferon signaling in brain microvascular endothelial cells during japanese encephalitis virus infection. Front Microbiol 13:894356. https:\/\/doi.org\/10.3389\/fmicb.2022.894356","journal-title":"Front Microbiol"},{"issue":"1","key":"1598_CR195","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12974-023-02891-x","volume":"20","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhang H, Chen H et al (2023a) Type i\/type iii ifn and related factors regulate jev infection and bbb endothelial integrity. J Neuroinflammation 20(1):216. https:\/\/doi.org\/10.1186\/s12974-023-02891-x","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR196","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01219-9","volume":"21","author":"D Zhang","year":"2023","unstructured":"Zhang D, Jian Y, Zhang Y et al (2023b) Short-chain fatty acids in diseases. Cell Commun Signal 21(1):212. https:\/\/doi.org\/10.1186\/s12964-023-01219-9","journal-title":"Cell Commun Signal"},{"issue":"5","key":"1598_CR197","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00116-24","volume":"98","author":"L Zhang","year":"2024","unstructured":"Zhang L, Nan X, Zhou D et al (2024a) Japanese encephalitis virus ns1 and ns1\u2019 protein disrupts the blood-brain barrier through macrophage migration inhibitory factor-mediated autophagy. J Virol 98(5):e11624. https:\/\/doi.org\/10.1128\/jvi.00116-24","journal-title":"J Virol"},{"key":"1598_CR198","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112083","volume":"133","author":"N Zhang","year":"2024","unstructured":"Zhang N, Wang G, Yang L et al (2024b) Intravenous immunoglobulin alleviates japanese encephalitis virus-induced peripheral neuropathy by inhibiting the asm\/ceramide pathway. Int Immunopharmacol 133:112083. https:\/\/doi.org\/10.1016\/j.intimp.2024.112083","journal-title":"Int Immunopharmacol"},{"issue":"20","key":"1598_CR199","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads7441","volume":"11","author":"H Zhang","year":"2025","unstructured":"Zhang H, Li D, Zheng J et al (2025a) Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection. Sci Adv 11(20):eads7441. https:\/\/doi.org\/10.1126\/sciadv.ads7441","journal-title":"Sci Adv"},{"issue":"1","key":"1598_CR200","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41591-024-03434-4","volume":"31","author":"K Zhang","year":"2025","unstructured":"Zhang K, Yang X, Wang Y et al (2025b) Artificial intelligence in drug development. Nat Med 31(1):45\u201359. https:\/\/doi.org\/10.1038\/s41591-024-03434-4","journal-title":"Nat Med"},{"issue":"5","key":"1598_CR201","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","volume":"163","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of the blood-brain barrier. Cell 163(5):1064\u20131078. https:\/\/doi.org\/10.1016\/j.cell.2015.10.067","journal-title":"Cell"},{"key":"1598_CR202","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2019.108430","volume":"238","author":"B Zheng","year":"2019","unstructured":"Zheng B, Wang X, Liu Y et al (2019) Japanese encephalitis virus infection induces inflammation of swine testis through rig-i-nf-\u0138b signaling pathway. Vet Microbiol 238:108430. https:\/\/doi.org\/10.1016\/j.vetmic.2019.108430","journal-title":"Vet Microbiol"},{"issue":"6","key":"1598_CR203","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s12250-018-0067-5","volume":"33","author":"D Zhou","year":"2018","unstructured":"Zhou D, Jia F, Li Q et al (2018) Japanese encephalitis virus ns1\u2019 protein antagonizes interferon beta production. Virol Sin 33(6):515\u2013523. https:\/\/doi.org\/10.1007\/s12250-018-0067-5","journal-title":"Virol Sin"},{"issue":"5","key":"1598_CR204","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.4049\/jimmunol.1900946","volume":"204","author":"D Zhou","year":"2020","unstructured":"Zhou D, Li Q, Jia F et al (2020) The Japanese encephalitis virus NS1\u2019 protein inhibits type I IFN production by targeting MAVS. J Immunol 204(5):1287\u20131298. https:\/\/doi.org\/10.4049\/jimmunol.1900946","journal-title":"J Immunol"},{"issue":"4","key":"1598_CR205","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1695","volume":"13","author":"X Zhou","year":"2021","unstructured":"Zhou X, Smith QR, Liu X (2021) Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target cns diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(4):e1695. https:\/\/doi.org\/10.1002\/wnan.1695","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"9","key":"1598_CR206","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00635-24","volume":"98","author":"J Zhou","year":"2024","unstructured":"Zhou J, Zhang M, Wang Q et al (2024) Two novel compounds inhibit flavivirus infection in vitro and in vivo by targeting lipid metabolism. J Virol 98(9):e63524. https:\/\/doi.org\/10.1128\/jvi.00635-24","journal-title":"J Virol"},{"issue":"5","key":"1598_CR207","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.4049\/jimmunol.1500370","volume":"195","author":"B Zhu","year":"2015","unstructured":"Zhu B, Ye J, Nie Y et al (2015) Microrna-15b modulates Japanese encephalitis virus-mediated inflammation via targeting RNF125. J Immunol 195(5):2251\u20132262. https:\/\/doi.org\/10.4049\/jimmunol.1500370","journal-title":"J Immunol"},{"key":"1598_CR208","doi-asserted-by":"publisher","DOI":"10.1038\/srep22581","volume":"6","author":"B Zhu","year":"2016","unstructured":"Zhu B, Ye J, Ashraf U et al (2016) Transcriptional regulation of mir-15b by c-rel and creb in japanese encephalitis virus infection. Sci Rep 6:22581. https:\/\/doi.org\/10.1038\/srep22581","journal-title":"Sci Rep"},{"issue":"1","key":"1598_CR209","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02852-4","volume":"20","author":"S Zhu","year":"2023","unstructured":"Zhu S, Tao M, Li Y et al (2023) H3k27me3 of rnf19a promotes neuroinflammatory response during japanese encephalitis virus infection. J Neuroinflammation 20(1):168. https:\/\/doi.org\/10.1186\/s12974-023-02852-4","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1598_CR210","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.virs.2023.12.004","volume":"39","author":"W Zhu","year":"2024","unstructured":"Zhu W, Li Q, Yin Y et al (2024) Ferroptosis contributes to jev-induced neuronal damage and neuroinflammation. Virol Sin 39(1):144\u2013155. https:\/\/doi.org\/10.1016\/j.virs.2023.12.004","journal-title":"Virol Sin"},{"key":"1598_CR211","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.701820","volume":"11","author":"S Zou","year":"2021","unstructured":"Zou S, Zou Q, Xiong W et al (2021) Brain microvascular endothelial cell-derived hmgb1 facilitates monocyte adhesion and transmigration to promote jev neuroinvasion. Front Cell Infect Microbiol 11:701820. https:\/\/doi.org\/10.3389\/fcimb.2021.701820","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Archives of Pharmacal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-026-01598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12272-026-01598-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12272-026-01598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:01:49Z","timestamp":1773856909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12272-026-01598-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":212,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1598"],"URL":"https:\/\/doi.org\/10.1007\/s12272-026-01598-w","relation":{},"ISSN":["0253-6269","1976-3786"],"issn-type":[{"value":"0253-6269","type":"print"},{"value":"1976-3786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"7 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}